Nocodazole (R17934)

For research use only. Not for use in humans.

目录号：S2775 别名： Oncodazole, NSC238159 中文名称：诺考达唑

CAS No. 31430-18-9

Nocodazole (R17934, Oncodazole, NSC238159)是一种微管聚合的快速可逆抑制剂，也抑制Abl、Abl(E255K)和Abl(T315I)，对应的IC50值分别为0.21 μM，0.53 μM和0.64 μM。Nocodazole可提高CRISPR介导的同源重组效率，对增强精确的基因编辑效力具有加成作用。Nocodazole可诱导凋亡。

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库存

购买数量

10mM (1mL in DMSO)	RMB 794.43	现货
10mg	RMB 580.33	现货
50mg	RMB 2217.08	现货
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客户使用Selleck生产的Nocodazole (R17934)发表文献80篇：

Cancer Cell, 2021, S1535-6108(21)00383-4

PubMed: 34388376 ( click the link to review the publication )

Nat Immunol, 2021, 10.1038/s41590-021-01090-1

PubMed: 34949833 ( click the link to review the publication )

Cell, 2020, 19;180(6):1198-1211.e19.

PubMed: 32200801 ( click the link to review the publication )

Nat Methods, 2020, 17(3):279-282

PubMed: 32066961 ( click the link to review the publication )

Front Cell Dev Biol, 2022, 10:817831

PubMed: 35309941 ( click the link to review the publication )

J Biol Chem, 2022, S0021-9258(22)00072-2

PubMed: 35085551 ( click the link to review the publication )

Mol Cancer Res, 2022, molcanres.0612.2021

PubMed: 34980594 ( click the link to review the publication )

Mol Cell, 2021, S1097-2765(21)00736-X

PubMed: 34562372 ( click the link to review the publication )

Nat Commun, 2021, 12(1):5977

PubMed: 34645816 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2021, 118(19)e2017645118

PubMed: 33947811 ( click the link to review the publication )

Cell Rep, 2021, 36(12):109740

PubMed: 34551298 ( click the link to review the publication )

Cell Rep, 2021, 34(10):108814

PubMed: 33691114 ( click the link to review the publication )

Cancer Lett, 2021, 526:53-65

PubMed: 34813892 ( click the link to review the publication )

Mol Cancer Ther, 2021, molcanther.0973.2020

PubMed: 34376580 ( click the link to review the publication )

Mol Oncol, 2021, 10.1002/1878-0261.13027

PubMed: 34058059 ( click the link to review the publication )

Cancer Sci, 2021, 112(12):4909-4919

PubMed: 34632667 ( click the link to review the publication )

Sci Rep, 2021, 11(1):21477

PubMed: 34728663 ( click the link to review the publication )

Sci Rep, 2021, 11(1):17893

PubMed: 34504177 ( click the link to review the publication )

Exp Cell Res, 2021, S0014-4827(21)00024-0

PubMed: 33485843 ( click the link to review the publication )

BMC Cancer, 2021, 21(1):784

PubMed: 34233647 ( click the link to review the publication )

Chembiochem, 2021, 22(20):2957-2965

PubMed: 34411391 ( click the link to review the publication )

Virol Sin, 2021, 1-11

PubMed: 34138404 ( click the link to review the publication )

Commun Biol, 2021, 4(1):1370

PubMed: 34876695 ( click the link to review the publication )

Cell Death Differ, 2021, 10.1038/s41418-020-00733-4

PubMed: 33531658 ( click the link to review the publication )
Nat Commun, 2020, 29;11(1):2086

PubMed: 32350249 ( click the link to review the publication )

PLoS Biol, 2020, 9;18(6):e3000288

PubMed: 32516310 ( click the link to review the publication )

J Cell Biol, 2020, 219(2)

PubMed: 31868888 ( click the link to review the publication )

Cancer Discov, 2020, CD-20-0818

PubMed: 33158843 ( click the link to review the publication )

Mol Cancer Ther, 2020, molcanther.0525.2020

PubMed: 33158997 ( click the link to review the publication )

Front Cell Dev Biol, 2020, 8:601972

PubMed: 33195286 ( click the link to review the publication )

Am J Cancer Res, 2020, 10(8):2649-2676

PubMed: 32905466 ( click the link to review the publication )

J Cell Physiol, 2020, 10.1002/jcp.30110

PubMed: 33169846 ( click the link to review the publication )

Exp Neurol, 2020, 324:113138

PubMed: 31794745 ( click the link to review the publication )

Cell Signal, 2020, 69:109546

PubMed: 31981797 ( click the link to review the publication )

Oncol Rep, 2020, 44(6):2621-2633

PubMed: 33125106 ( click the link to review the publication )

Commun Biol, 2020, 3(1):593

PubMed: 33087841 ( click the link to review the publication )

Cancer Res, 2020, 80(23):5203-5215

PubMed: 33051252 ( click the link to review the publication )

Nucleic Acids Res, 2020, gkaa570

PubMed: 32652013 ( click the link to review the publication )

Commun Biol, 2020, 5;3(1):287

PubMed: 32504010 ( click the link to review the publication )

Nat Commun, 2019, 10(1):620

PubMed: 30728358 ( click the link to review the publication )

Nucleic Acids Res, 2019, 10.1093/nar/gkz602

PubMed: 31291454 ( click the link to review the publication )

EMBO J, 2019, 38(8)

PubMed: 30858281 ( click the link to review the publication )

EMBO J, 2019, 10.15252/embj.2019101863

PubMed: 31769059 ( click the link to review the publication )

Cancer Res, 2019, 10.1158/0008-5472

PubMed: 31484670 ( click the link to review the publication )

Cell Death Differ, 2019, 10.1038/s41418-019-0441-3

PubMed: 31645676 ( click the link to review the publication )

Elife, 2019, 8e44161

PubMed: 30860482 ( click the link to review the publication )

FEBS J, 2019, 286(5):963-974

PubMed: 30600590 ( click the link to review the publication )

J Cell Sci, 2019, 132(20)

PubMed: 31519809 ( click the link to review the publication )
J Virol, 2019, 93(4)

PubMed: 30487274 ( click the link to review the publication )

PLoS Negl Trop Dis, 2019, 13(5):e0007425

PubMed: 31095613 ( click the link to review the publication )

Mol Pharmacol, 2019, 96(6):711-719

PubMed: 31585985 ( click the link to review the publication )

Dev Biol, 2019, 456(2):201-211

PubMed: 31479647 ( click the link to review the publication )

Cancer Immunol Res, 2019,

PubMed: 31399419 ( click the link to review the publication )

Cancer Biol Med, 2019, 16(1):66-83

PubMed: 31119047 ( click the link to review the publication )

EMBO Mol Med, 2018, 10(9)

PubMed: 30108112 ( click the link to review the publication )

EMBO Rep, 2018, 19(1):43-56

PubMed: 29138236 ( click the link to review the publication )

EMBO Rep, 2018, 19(4)e45484

PubMed: 29491004 ( click the link to review the publication )

Oncogene, 2018, 37(22):2936-2952

PubMed: 29520102 ( click the link to review the publication )

Cell Death Dis, 2018, 9(2):123

PubMed: 29374144 ( click the link to review the publication )

Sci Adv, 2018, 4(9):eaar4666

PubMed: 30263952 ( click the link to review the publication )

Biochem Biophys Res Commun, 2018, 499(4):927-933

PubMed: 29626471 ( click the link to review the publication )

J Biol Chem, 2018, 10.1074/jbc.RA118.006046

PubMed: 30498087 ( click the link to review the publication )

J Biol Chem, 2018, 10.1074/jbc.RA118.005978

PubMed: 30523151 ( click the link to review the publication )

Sci Rep, 2018, 8(1):11255

PubMed: 30050147 ( click the link to review the publication )

J Mol Cell Cardiol, 2018, 124:58-69

PubMed: 30315806 ( click the link to review the publication )

Pain, 2018, 159(8):1518-1528

PubMed: 29613911 ( click the link to review the publication )

Cancer Res, 2018, 10.1158/0008-5472.CAN-18-0520

PubMed: 30498084 ( click the link to review the publication )

Cell Discov, 2017, 3:16049

PubMed: 28101375 ( click the link to review the publication )

J Biol Chem, 2017, 292(36):15028-15038

PubMed: 28739871 ( click the link to review the publication )

Front Cell Infect Microbiol, 2017, 7:400

PubMed: 28932708 ( click the link to review the publication )

Cell Signal, 2017, 39:74-83

PubMed: 28780319 ( click the link to review the publication )

Oncotarget, 2017, 8(25):40654-40667

PubMed: 28489565 ( click the link to review the publication )
J Biol Chem, 2017, 292(19):7806-7816

PubMed: 28320862 ( click the link to review the publication )

Cell Rep, 2016, 14(6):1555-1566

PubMed: 26854237 ( click the link to review the publication )

FEBS J, 2016, 283(1):102-11

PubMed: 26462166 ( click the link to review the publication )

J Biol Chem, 2016, 10.1074/jbc.M116.722751

PubMed: 27226586 ( click the link to review the publication )

Cell Signal, 2016, 28(12):1826-1832

PubMed: 27566175 ( click the link to review the publication )

J Transl Med, 2016, 14(1):346

PubMed: 27998273 ( click the link to review the publication )

Cell Death Dis, 2016, 7:e2195

PubMed: 27077811 ( click the link to review the publication )

J Immunol, 2015, 10.4049/jimmunol.1402897

PubMed: 25762780 ( click the link to review the publication )

产品安全说明书

Microtubule Associated抑制剂选择性比较

生物活性

产品描述

靶点

Microtubules ^[2] (Cell-free assay)	Abl ^[1] (Cell-free assay)	Abl (E255K) ^[1] (Cell-free assay)	Abl (T315I) ^[1] (Cell-free assay)
	0.21 μM	0.53 μM	0.64 μM

体外研究

Nocodazole是癌症相关激酶的高亲和力配体，如的磷酸化ABL, c-KIT, BRAF, 和 MEK ，K_d值分别为0.091 μM, 1.6 μM, 1.8 μM 和1.6 μM,。此外，Nocodazole对ABL(E255K)磷酸化, ABL(T315I) 磷酸化, BRAF(V600E) 和 PI3Kγ 的K_d值分别是0.12 μM, 0.17 μM, 1.1 μM 和1.5 μM。Nocodazole诱导慢性淋巴细胞白血病细胞凋亡；抑制胰岛素刺激的葡萄糖转运；在人类结肠癌细胞减少细胞凋亡；损害内侧神经节嵴细胞的形态和方向迁移^[1]。Nocodazole于高浓度时，在细胞中迅速解聚微管，而低浓度可抑制微管的动态不稳定^[2]。用Nocodazole处理经同步化6小时的分裂期细胞，加入不同浓度的紫杉醇后，可造成G₁期阻滞，半数抑制浓度为4nM。紫杉醇处理经Nocodazole预处理的细胞，在无Nocodazole的条件下，细胞仅能形成游离微管，而在有Nocodazole存在的条件下，则可形成聚集的中心体微管^[3]。 Nocodazole通过结合β-微管蛋白破坏微管，可阻碍二硫键形成和囊泡运输，抑制METH诱导的细胞凋亡和溶酶体功能障碍。Nocodazole预处理可显著减少METH诱导的细胞凋亡^[4]。在iPSC中，Nocodazole可使HDR效率加倍，可高达30%^[6]。

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
L1210 murine leukemia cell	Mn72S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MVPJckB3cXS{bzDmc5IhcXS\|IHnubIljcXSxcomgZYN1cX[rdImgZYdicW6\|dDDMNVIyOCCvdYLpcoUhdGW3a3XtbYEh[2WubDDndo94fGhuIFnDOVA:Ozhibl2=	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN6MUS2K\|4yPzN6MUS2QE9iRg>?
LT12	M4S1OmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		Mk\ROFghcHK\|	MkT4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDyZZQhVFRzMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhYFSWIHHzd4F6NCCLQ{WwJF0hOC5yME[g{txONg>?	NW\uSYE1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlAxOThpPkG5NlIxODF6PD;hQi=>
HepG2	M2XMRmZ2dmO2aX;uJIF{e2G7	M{\KZVAvOSC2bzCxNEB2VQ>?	M3PIOlEhcHJ?	MWjJcohq[mm2aX;uJI9nKFSQRnHsdIhiNWmwZIXj[YQhVk[tYYDwZWIhMHWwa37ve44hd3KrZ3nuLU1l\XCnbnTlcpQhfHKjboPjdolxfGmxbnHsJIFkfGm4aYT5JIV5eHKnc4Pl[EBqdiCqdX3hckBJ\XCJMjDj[YxteyCjdDCwMlEhfG9iMUCgeW0hcW6ldXLheIVlKG[xcjCxJIhzKHC{aX;yJJRwKFSQRnHsdIhiKGmwZIXjeIlwdiCvZXHzeZJm\CCjZoTldkA3KGi{czDifUBlfWGuLXz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfS=>	M33Be\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEK3OVIzLz5{NUiyO\|UzOjxxYU6=
PANC1	M4jrZmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NF\VRZA1QCCqcoO=	MonJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCSQV7DNUBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNUDPxE1w	NEnNeGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[4PFE6Oyd-Mke2PFgyQTN:L3G+
HeLa	NFrVVG9CdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MofPOFghcHK\|	NY\PUYgzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO\|YYmsJGdKPTBiPTCwMlAyKM7:TT6=	NGDK[489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[4PFE6Oyd-Mke2PFgyQTN:L3G+
MDA-MB-231	M3zjdWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NEnzbnI1QCCqcoO=	Mle2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUAxNjBzIN88UU4>	M3:1TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Nki4NVk{Lz5{N{[4PFE6OzxxYU6=
A549	MXXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NHnLW4o1QCCqcoO=	M1TTdWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJINmdGxicILvcIln\XKjdHnvckBie3OjeTygS2k2OCB;IECuNFEh\|ryPLh?=	NIDkXZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUC4PVI{Oyd-MkmwPFkzOzN:L3G+
HeLa	MVLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M{PsflQ5KGi{cx?=	MmWyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKZVzhJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZ4VtdCCycn;sbYZmemG2aX;uJIF{e2G7LDDHTVUxKD1iMD6wNUDPxE1w	MnywQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyOEmyN\|MoRjJ7MEi5NlM{RC:jPh?=
MDA-MB-231	NXOxO\|VvSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MWC0PEBpenN?	NVnnZo83SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZ4VtdCCycn;sbYZmemG2aX;uJIF{e2G7LDDHTVUxKD1iMD6wNUDPxE1w	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTB6OUKzN{c,OjlyOEmyN\|M9N2F-
HeLa	NYPmbXBvSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NUC4VIxsPDhiaILz	NUPhO5FPSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO\|YYmsJGdKPTBiPTCwMlAyPSEQvF2u	NFjoS\|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUiyO\|UzOid-MkW4Nlc2OjJ:L3G+
MDA-MB-231	MWHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M4HQeVQ5KGi{cx?=	Mn3jRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUAxNjBzNzFOwG0v	M3HSSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEK3OVIzLz5{NUiyO\|UzOjxxYU6=
A549	NH2xdmVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NFS1NGg1QCCqcoO=	MnPVRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCDNUS5JINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCyJO69VS5?	M1nE[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEK3OVIzLz5{NUiyO\|UzOjxxYU6=
L1210	M3\UVWZ2dmO2aX;uJIF{e2G7		MnjxOFghcHK\|	M3mz[GlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IIDyc4xq\mW{YYTpc44hd2ZiY4XseJVz\WRibIntdIhwcWRibHX1b4VucWFiTEGyNVAh[2WubIOg[JVzcW6pIES4JIhzeyxiSVS1NEA:KDBwMEK3JO69VS5?	NH3jWHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95MUOxOFg{Lz55MUOxOFg{RC:jPh?=
PANC1	NF74NXNCdnSrY3HuZ4VzKGG\|c3H5		NUTtNnVGPDhiaILz	NEHzUndCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gVGFPSzFiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvODJ7IN88UU4>	M4DCVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUOwN\|U4Lz5{N{GzNFM2PzxxYU6=
A549	MUfDfZRwfG:6aXPpeJkh[XO\|YYm=		NVSzdYVzOjRiaILz	NU\oV5FvS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yM{[2JO69VS5?	M3rsUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUGwNVM4Lz5{MEGxNFE{PzxxYU6=
NCI60	NV:zSmg4T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NFzWfYo1QCCqcoO=	NHnwU5ZIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBPS0l4MDDj[YxteyCrbnP1ZoF1\WRiZn;yJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxKD1iMD6wN\|g6KM7:TT6=	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl3NkCzPEc,Ojd7NU[wN\|g9N2F-
P388	MVfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M4O3UVQ5KGi{cx?=	NYDwTmNRSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDQN\|g5KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDYWHQh[XO\|YYmsJGlEPTBiPTCwMlA1KM7:TT6=	NVPPV495RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlAxOThpPkG5NlIxODF6PD;hQi=>
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LT12	M2\sTmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M{PjflQ5KGi{cx?=	NHfyNmJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JJJifCCOVEGyJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSC[VGSgZZN{[XluIFnDOVAhRSByLkC0JO69VS5?	NHj3R2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEWzO\|c3PSd-MkC1N\|c4PjV:L3G+
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BT549	MUDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M1jxeFQ5KGi{cx?=	MXXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKWNUS5JINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCjbHHtZZIh[my3ZTDhd5NigSxiSVO1NEA:KDBwME[5JO69VS5?	Ml;qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3NkO3OVAoRjJzNU[zO\|UxRC:jPh?=
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HeLa	M3PlO2Z2dmO2aX;uJIF{e2G7	NEC3elMxNjFidV2=	MVOyOEBpenN?	NGnUfIVKdmirYnn0bY9vKG:oIIT1ZpVtcW5icH;sfY1memm8YYTpc44hcW5iaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDzbIlnfCCxZjD0eYJ2dGmwIIDyc5RmcW5idH:gd49tfWKuZTDmdoFkfGmxbjDheEAxNjFidV2gZYZ1\XJiMkSgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=>	NHywOpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUWwNVk1OCd-Mkm1NFE6PDB:L3G+
PC3MLN4	MoX6SpVv[3Srb36gZZN{[Xl?	NVf0S5VXOSC3TR?=	M1HsPFI1KGi{cx?=	M1jsZXVxemWpdXzheIlwdiCxZjDDfYNtcW5vQkGgdJJwfGWrbjDlfJBz\XO\|aX;uJIlvKGi3bXHuJHBEO02OTkSgZ4VtdHNiYYSgNUB2VSCjZoTldkAzPCCqcoOgZpkhX2W\|dHXyckBjdG:2IH3leIhw\A>?	NX\VV\|h2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyPFg6OzlpPkK5Nlg5QTN7PD;hQi=>
PC3MLN4	MVnGeY5kfGmxbjDhd5NigQ>?	M4n4dlEhfU1?	NUnMNZRFPDhiaILz	NXTjT4VSTGm\|coXweIlwdiCxZjDtbYNzd3S3YoXs[UBlgW6jbXnjd{BqdiCqdX3hckBRSzOPTF60JINmdGy\|IHH0JFEhfU1iYX\0[ZIhPDhiaILzJIJ6KGmvbYXuc4ZtfW:{ZYPj[Y5k\SCvaXPyc5Nkd3CrYzDt[ZRpd2R?	MnnrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{OEi5N\|koRjJ7Mki4PVM6RC:jPh?=
MCF7	MVjGeY5kfGmxbjDhd5NigQ>?	M2K5[VEhfU1?	MoTMOEBpenN?	M3rTdWlv\HWldHnvckBw\iC2dXL1cIlvKGSncH;sfY1memm8YYTpc44hcW5iaIXtZY4hVUOINzDj[YxteyCjdDCxJJVOKGGodHXyJFQhcHK\|IHL5JHdme3Sncn6gZoxwfCCvZYToc4Q>	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ6OUeyPEc,Ojd4OEm3Nlg9N2F-
Jurkat	M3f5e2Z2dmO2aX;uJIF{e2G7	NWT0W\|RFOSC3TR?=	MYq0JIhzew>?	M1LESmlv\HWldHnvckBw\iC2dXL1cIlvKGSncH;sfY1memm8YYTpc44hcW5iaIXtZY4hUnW{a3H0JINmdGy\|IHH0JFEhfU1iYX\0[ZIhPCCqcoOgZpkhX2W\|dHXyckBjdG:2IH3leIhw\A>?	NWrGPZh3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2PFk4OjhpPkK3Olg6PzJ6PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	Cdc2 / cyclin B1 / MAD2 / Cdc20 ; PubMed: 21918689 PLoS One E (upper part). Time-dependent changes in cyclin B1 and Cdc2 protein levels following nocodazole treatment. Cells were treated with nocodazole (250 nM) for the length of time as indicated, and whole cell lysates were prepared. An equal amount of protein lysates was electrophoretically separated on the 10% SDS-polyacrylamide gel, and transferred to nitrocellulose membrane. Western blots were detected using specific antibodies against cyclin B1, Cdc2 (CDK1), MAD2, and Cdc20 on an enhanced chemiluminescence (ECL) apparatus. Membrane was stripped for determining the levels of GAPDH as a loading control. E (lower part). The relative protein levels for cyclin B1, Cdc2, MAD2, and Cdc20 were calculated according to their densitometry readings, which were normalized according to the corresponding readings for the GAPDH protein bands. Each value is mean ± S.D. from three replicate determinations. * P<0.05, ** P<0.01 versus vehicle-treated control.	21918689
Immunofluorescence	Brd4 / α-tubulin ; PubMed: 22567088 PLoS One Cells were treated with indicated concentrations of nocodazole for 4 h, and mitotic cells were immunostained for endogenous Brd4 and α-tubulin. DNA was stained by Hoechst33324. Tubulin / LC8 ; PubMed: 23038268 J Biol Chem Shown is endogenous LC8 colocalized with microtubules in HeLa cells. Control, 20 nm taxol- and 100 nm nocodazole-treated cells were stained with α-tubulin and LC8 antibodies. Scale bar, 20 μm.	22567088 23038268
Growth inhibition assay	Cell viability ; PubMed: 21918689 PLoS One Changes in cell viability (MTT assay) after treatment of cells with 250 nM nocodazole for different lengths of time. Each data point is the mean ± S.D. from four replicate measurements from one representative experiment.	21918689

体内研究

Ketoconazole和Nocodazole联合使用比单独使用可更强地抑制小鼠的肿瘤体积和肿瘤重量。在COLO205肿瘤移植模型中联合使用的诱导凋亡效果也比单独使用更明显^[5]。

动物实验： ^[5]	- 合并 Animal Models: COLO-205肿瘤移植裸鼠 Dosages: 5 mg/kg Administration: 腹腔注射 (Only for Reference)

参考文献

- 合并

溶解度 (25°C)

体外	DMSO	7 mg/mL (23.23 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 2% DMSO+30% PEG 300+2% Tween 80+ddH2O	1mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Nocodazole (R17934) SDF

分子量	301.32
化学式	C₁₄H₁₁N₃O₃S
CAS号	31430-18-9
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	Oncodazole, NSC238159

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

研究领域

产品类型

定制您的化合物库

Nocodazole (R17934)

客户使用Selleck生产的Nocodazole (R17934)发表文献80篇：

产品安全说明书

Microtubule Associated抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Nocodazole (R17934) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

技术支持

Microtubule Associated Signaling Pathway Map

相关Microtubule Associated产品