Nocodazole (R17934)

目录号:S2775 别名: Oncodazole, NSC238159 中文名称:诺考达唑

仅限科研使用

Nocodazole (R17934, Oncodazole, NSC238159)是一种微管聚合的快速可逆抑制剂,也抑制AblAbl(E255K)Abl(T315I),对应的IC50值分别为0.21 μM,0.53 μM和0.64 μM。Nocodazole可提高CRISPR介导的同源重组效率,对增强精确的基因编辑效力具有加成作用。Nocodazole可诱导凋亡。

Nocodazole (R17934) Chemical Structure

CAS: 31430-18-9

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 794.43 现货
RMB 580.33 现货
RMB 2217.08 现货
大包装 有超大折扣

今日订购,明日送达 全国免运费 分装免费 分装成小规格产品(单支最小为1mg)
如1支10mg产品可分装为10支1mg产品

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Nocodazole (R17934)发表文献86篇:

产品安全说明书

Microtubule Associated抑制剂选择性比较

相关Microtubule Associated产品

生物活性

产品描述 Nocodazole (R17934, Oncodazole, NSC238159)是一种微管聚合的快速可逆抑制剂,也抑制AblAbl(E255K)Abl(T315I),对应的IC50值分别为0.21 μM,0.53 μM和0.64 μM。Nocodazole可提高CRISPR介导的同源重组效率,对增强精确的基因编辑效力具有加成作用。Nocodazole可诱导凋亡。
靶点
Microtubules [2]
(Cell-free assay)
Abl [1]
(Cell-free assay)
Abl (E255K) [1]
(Cell-free assay)
Abl (T315I) [1]
(Cell-free assay)
0.21 μM 0.53 μM 0.64 μM
体外研究

Nocodazole是癌症相关激酶的高亲和力配体,如的磷酸化ABL, c-KIT, BRAF, 和 MEK ,Kd值分别为0.091 μM, 1.6 μM, 1.8 μM 和1.6 μM,。此外,Nocodazole对ABL(E255K)磷酸化, ABL(T315I) 磷酸化, BRAF(V600E) 和 PI3Kγ 的Kd值分别是0.12 μM, 0.17 μM, 1.1 μM 和1.5 μM。Nocodazole诱导慢性淋巴细胞白血病细胞凋亡;抑制胰岛素刺激的葡萄糖转运;在人类结肠癌细胞减少细胞凋亡;损害内侧神经节嵴细胞的形态和方向迁移[1]。Nocodazole于高浓度时,在细胞中迅速解聚微管,而低浓度可抑制微管的动态不稳定[2]。用Nocodazole处理经同步化6小时的分裂期细胞,加入不同浓度的紫杉醇后,可造成G1期阻滞,半数抑制浓度为4nM。紫杉醇处理经Nocodazole预处理的细胞,在无Nocodazole的条件下,细胞仅能形成游离微管,而在有Nocodazole存在的条件下,则可形成聚集的中心体微管[3]。 Nocodazole通过结合β-微管蛋白破坏微管,可阻碍二硫键形成和囊泡运输,抑制METH诱导的细胞凋亡和溶酶体功能障碍。Nocodazole预处理可显著减少METH诱导的细胞凋亡[4]。在iPSC中,Nocodazole可使HDR效率加倍,可高达30%[6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
L1210 murine leukemia cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWHJckB3cXS{bzDmc5IhcXS|IHnubIljcXSxcomgZYN1cX[rdImgZYdicW6|dDDMNVIyOCCvdYLpcoUhdGW3a3XtbYEh[2WubDDndo94fGhuIFnDOVA:Ozhibl2= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN6MUS2K|4yPzN6MUS2QE9iRg>?
LT12 MmjCRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NWfhT4hMPDhiaILz NHHjRmxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JJJifCCOVEGyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSC[VGSgZZN{[XluIFnDOVAhRSByLkCwOkDPxE1w M1XOXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkKwNFE5Lz5zOUKyNFAyQDxxYU6=
HepG2 NX\kZXNPTnWwY4Tpc44h[XO|YYm= M4njdlAvOSC2bzCxNEB2VQ>? M4\G[|EhcHJ? NEPjeZJKdmirYnn0bY9vKG:oIGTOSoFteGijLXnu[JVk\WRiTl\rZZBx[UJiKIXub45wf25ib4Lp[4lvMS2mZYDlcoRmdnRidILhcpNkemmydHnvcoFtKGGldHn2bZR6KGW6cILld5Nm\CCrbjDoeY1idiCKZYDHNkBk\WyuczDheEAxNjFidH:gNVAhfU1iaX7jeYJifGWmIH\vdkAyKGi{IIDybY9zKHSxIGTOSoFteGijIHnu[JVkfGmxbjDt[YF{fXKnZDDh[pRmeiB4IHjyd{BjgSCmdXHsMYx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigQ>? M4DpRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEK3OVIzLz5{NUiyO|UzOjxxYU6=
PANC1 M1HXTmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MXW0PEBpenN? NFr3XG1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDBUmMyKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAyKM7:TT6= M13YeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Nki4NVk{Lz5{N{[4PFE6OzxxYU6=
HeLa MkLVRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NUnWXnBRPDhiaILz NVztPGFDSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAyKM7:TT6= M2PHTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Nki4NVk{Lz5{N{[4PFE6OzxxYU6=
MDA-MB-231 NIDMVoVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MoTFOFghcHK| MmP4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUAxNjBzIN88UU4> M2S1elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Nki4NVk{Lz5{N{[4PFE6OzxxYU6=
A549 M2e2dGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NGDEemo1QCCqcoO= NGP2emxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBk\WyuIIDyc4xq\mW{YYTpc44h[XO|YYmsJGdKPTBiPTCwMlAyKM7:TT6= Mlz1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyOEmyN|MoRjJ7MEi5NlM{RC:jPh?=
HeLa NH7hcWNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MlvXOFghcHK| MYfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEinTHGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDj[YxtKHC{b3zp[oVz[XSrb36gZZN{[XluIFfJOVAhRSByLkCxJO69VS5? NE\ZUIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUC4PVI{Oyd-MkmwPFkzOzN:L3G+
MDA-MB-231 M4Gxb2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mm\MOFghcHK| NWC4[o17SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZ4VtdCCycn;sbYZmemG2aX;uJIF{e2G7LDDHTVUxKD1iMD6wNUDPxE1w MknuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyOEmyN|MoRjJ7MEi5NlM{RC:jPh?=
HeLa Mnu4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M1TCXVQ5KGi{cx?= Mn;yRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCxOUDPxE1w NVrPPYQ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4Nlc2OjJpPkK1PFI4PTJ{PD;hQi=>
MDA-MB-231 M1H2WmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M4noT|Q5KGi{cx?= NI[3NmFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDBwMEG3JO69VS5? NXHzNXJ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4Nlc2OjJpPkK1PFI4PTJ{PD;hQi=>
A549 MkHNRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NYPPWIRXPDhiaILz NXnr[mR7SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCwMlAzKM7:TT6= MlL4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6Mke1NlIoRjJ3OEK3OVIzRC:jPh?=
L1210 M4TxbWZ2dmO2aX;uJIF{e2G7 MoP2OFghcHK| MUTJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCycn;sbYZmemG2aX;uJI9nKGO3bIT1doVlKGy7bYDoc4llKGyndXvlcYliKExzMkGwJINmdGy|IHT1dolv\yB2ODDodpMtKEmGNUCgQUAxNjB{NzFOwG0v MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84OTNzNEizK|44OTNzNEizQE9iRg>?
PANC1 M13jO2FvfGmlYX7j[ZIh[XO|YYm= M3T5WFQ5KGi{cx?= MVLBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFHOR|Eh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFI6KM7:TT6= NGDHTI89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GzNFM2Pyd-MkexN|A{PTd:L3G+
A549 NGC0N5FEgXSxdH;4bYNqfHliYYPzZZk> NUPVdFhJOjRiaILz NVr2OnlzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yM{[2JO69VS5? MnS3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMUCxN|coRjJyMUGwNVM4RC:jPh?=
NCI60 M4\5cWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NILvc2w1QCCqcoO= MmOwS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUmNKPjBiY3XscJMhcW6ldXLheIVlKG[xcjC0PEBpenNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NEA:KDBwMEO4PUDPxE1w NHzqS2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m1OlA{QCd-Mke5OVYxOzh:L3G+
P388 MofPRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NWjLfVZZPDhiaILz Mo\iRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCSM{i4JINmdGy|IHHmeIVzKDR6IHjyd{BjgSC[VGSgZZN{[XluIFnDOVAhRSByLkC0JO69VS5? MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{MECxPEc,OTl{MkCwNVg9N2F-
LT12 NUSzcHhlSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MkXwOFghcHK| MWXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFzUNVIh[2WubIOgZpkhYFSWIHHzd4F6KGGodHXyJFQ5KGi{czygTWM2OCB;IECuNFQh|ryPLh?= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG2OEc,OTdzOEGxOlQ9N2F-
LT12 NGL5NnZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1\veFQ5KGi{cx?= MkW2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDyZZQhVFRzMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhYFSWIHHzd4F6NCCLQ{WwJF0hOC5yNDFOwG0v NHL2UJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEWzO|c3PSd-MkC1N|c4PjV:L3G+
LT12 NEnreWJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3vPTVQ5KGi{cx?= NIHveZVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JJJifCCOVEGyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSC[VGSgZZN{[XluIFnDOVAhRSByLkC0JO69VS5? NXKxXlMzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3NFUzOjNpPkKxO|A2OjJ|PD;hQi=>
MDA-MB-231 NIr1XYhCdnSrY3HuZ4VzKGG|c3H5 NHT4SZk1QCCqcoO= MUHBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwJF0hOC5yNEKg{txONg>? NUnIO|N3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexN|A{PTdpPkK3NVMxOzV5PD;hQi=>
L1210 MWjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M3L0W|Q5KGi{cx?= M3;3NGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgUFEzOTBiY3XscJMh[nliWGTUJIF{e2G7IHHmeIVzKDR6IHjyd{whUUN3MDC9JFAvODVizszNMi=> NX60UXgzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPjRpPkG3NVgyOTZ2PD;hQi=>
P388 NUfxblFnSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NVTrWnc6PDhiaILz MYfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKGGmcnnhcZlkcW5vcnXzbZN1[W62IGCzPFgh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGjUWEBie3OjeTygTWM2OCB;IECuNFUh|ryPLh?= M{PUOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUezN|YyLz5zN{m3N|M3OTxxYU6=
L12 MU\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NYrVemhmPDhiaILz NYjkTZVwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBz[XRibYXseIllenWpLYLld4l{fGGwdDDMNVIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGjUWEBie3OjeTygTWM2OCB;IECuNFUh|ryPLh?= M3HGOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUezN|YyLz5zN{m3N|M3OTxxYU6=
L1210 NUjRbGFZSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NIXpUlI1QCCqcoO= NX\G[|lESW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDMNVIyOCClZXzsd{Bi\nSncjC0PEBpenNiYomgXHRVKGG|c3H5MEBKSzVyIE2gNE4xPSEQvF2u NVzCfFRNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC1N|c4PjVpPkKwOVM4PzZ3PD;hQi=>
P388 M4nBTmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MWG0PEBpenN? MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFHEVk1z\XOrc4ThcpQhdW:3c3WgVFM5QCClZXzsd{Bi\nSncjC0PEBpenNiYomgXHRVKGG|c3H5MEBKSzVyIE2gNE4xPSEQvF2u NHr0TZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUewOVIzOyd-MkG3NFUzOjN:L3G+
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SK-N-MC Ml;QdWhVWyCjc4PhfS=> NWfQWI1XeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?= NV3vS4Y3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
BT-12 NVm5dIFxeUiWUzDhd5NigQ>? NXLIO2cxeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhSlRvMUKgZ4VtdHN? Ml;jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
LAN-5 M3jmbJFJXFNiYYPzZZk> NIi4U5NyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBNSU5vNTDj[Yxtew>? NVPVVmVGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
DAOY M1jmPJFJXFNiYYPzZZk> NYrLdXJ7eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhTEGRWTDj[Yxtew>? M37FcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
BT-37 NUfmV|dHeUiWUzDhd5NigQ>? NYHtNHl[eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhSlRvM{egZ4VtdHN? NXju[FZPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
TC32 MYTxTHRUKGG|c3H5 MUPxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDUR|MzKGOnbHzz NWHvWIt5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
MG 63 (6-TG R) Mo\odWhVWyCjc4PhfS=> NWLCTVRZeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhVUdiNkOgLFYuXEdiUjmgZ4VtdHN? MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
U-2 OS NGSxcWlyUFSVIHHzd4F6 MkP2dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgWU0zKE:VIHPlcIx{ NH7x[2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
RD NEfNeJRyUFSVIHHzd4F6 NWrYTFl7eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhWkRiY3XscJM> Mn3rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
Saos-2 NVWwdoZqeUiWUzDhd5NigQ>? M4jkXZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHNid3NvMjDj[Yxtew>? M17YW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
OHS-50 M2jMV5FJXFNiYYPzZZk> NEntb4RyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBQUFNvNUCgZ4VtdHN? M1LxVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
HeLa MnLxSpVv[3Srb36gZZN{[Xl? NVfSdGRPOjRiaILz NWHuVJFuUW6qaXLpeIlwdiCxZjD0eYJ2dGmwIIDvcJlu\XKrenH0bY9vKGmwIHj1cYFvKEinTHGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4he2:udXLs[UB1fWK3bHnuJIZz[WO2aX;uJIFnfGW{IEK0JIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDhzOEe2PEc,Ojh6MUi3Olg9N2F-
HeLa MkjqSpVv[3Srb36gZZN{[Xl? MlLuNE4yKHWP NHLVcZgzPCCqcoO= M3PZO2lvcGmkaYTpc44hd2ZidIXieYxqdiCyb3z5cYVzcXqjdHnvckBqdiCqdX3hckBJ\UyjIHPlcIx{KGG|c3Xzd4VlKGG|IIPobYZ1KG:oIIT1ZpVtcW5icILveIVqdiC2bzDzc4x2[mynIH\yZYN1cW:wIHH0JFAvOSC3TTDh[pRmeiB{NDDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz M{j1UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUCxPVQxLz5{OUWwNVk1ODxxYU6=
PC3MLN4 MVTGeY5kfGmxbjDhd5NigQ>? MXOxJJVO Mk\QNlQhcHK| MkjOWZBz\We3bHH0bY9vKG:oIFP5Z4xqdi2EMTDwdo91\WmwIHX4dJJme3Orb36gbY4hcHWvYX6gVGM{VUyQNDDj[YxteyCjdDCxJJVOKGGodHXyJFI1KGi{czDifUBY\XO2ZYLuJIJtd3RibXX0bI9l MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ6OEmzPUc,Ojl{OEi5N|k9N2F-
PC3MLN4 NHPnfnFHfW6ldHnvckBie3OjeR?= MX[xJJVO NXPOe|U6PDhiaILz M{L3OGRqe3K3cITpc44hd2ZibXnjdo91fWK3bHWg[Jlv[W2rY4OgbY4hcHWvYX6gVGM{VUyQNDDj[YxteyCjdDCxJJVOKGGodHXyJFQ5KGi{czDifUBqdW23bn;mcJVwemW|Y3XuZ4UhdWmlcn;zZ49xcWNibXX0bI9l NUTi[3pnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyPFg6OzlpPkK5Nlg5QTN7PD;hQi=>
MCF7 MWDGeY5kfGmxbjDhd5NigQ>? NGH5XXgyKHWP MnHXOEBpenN? NHO5XYVKdmS3Y4Tpc44hd2ZidIXieYxqdiCmZYDvcJlu\XKrenH0bY9vKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYSgNUB2VSCjZoTldkA1KGi{czDifUBY\XO2ZYLuJIJtd3RibXX0bI9l MkfNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4OEm3NlgoRjJ5Nki5O|I5RC:jPh?=
Jurkat NULneGFjTnWwY4Tpc44h[XO|YYm= MlfqNUB2VQ>? Mkn0OEBpenN? MVrJcoR2[3Srb36gc4YhfHWkdXzpckBl\XCxbInt[ZJqgmG2aX;uJIlvKGi3bXHuJGp2emujdDDj[YxteyCjdDCxJJVOKGGodHXyJFQhcHK|IHL5JHdme3Sncn6gZoxwfCCvZYToc4Q> MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ6OUeyPEc,Ojd4OEm3Nlg9N2F-
Assay
Methods Test Index PMID
Western blot Cdc2 / cyclin B1 / MAD2 / Cdc20 21918689
Immunofluorescence Brd4 / α-tubulin Tubulin / LC8 22567088 23038268
Growth inhibition assay Cell viability 21918689
体内研究 Ketoconazole和Nocodazole联合使用比单独使用可更强地抑制小鼠的肿瘤体积和肿瘤重量。在COLO205肿瘤移植模型中联合使用的诱导凋亡效果也比单独使用更明显[5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

动物实验:

[5]

  • Animal Models: COLO-205肿瘤移植裸鼠
  • Dosages: 5 mg/kg
  • Administration: 腹腔注射

溶解度(25°C)

体外

体内

从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O

1mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 301.32
化学式

C14H11N3O3S

CAS号 31430-18-9
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

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