Verteporfin

目录号:S1786 别名: CL 318952

Verteporfin  Chemical Structure

Molecular Weight(MW): 718.79

Verteporfin 是一种能够抑制YAP-TEAD相互作用的小分子化合物,抑制YAP诱导的肝脏过度生长。同时,它还是一种有效的衍生自卟啉的第二代光敏剂。

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RMB 7928.11 现货
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客户使用Selleck该产品发表文献11篇:

客户使用该产品的6个实验数据:

  • Verteporfin treatment inhibits proliferation and induces apoptosis of Tsc1-null cells in vivo. Mice were administered i.p. with vehicle or verteporfin at a dose of 100 mg/kg every other day for 10 d before sacrifice. Mice were sacrificed at 6 wk of age. Three independent experiments were performed and mice in different treatments were pooled for analysis. Percentage of Ki67 and αSMA double-positive cells in α-SMA+ mesenchymal lesions in the indicated kidneys. Immunofluorescence staining and counting were performed on three sagittal sections from different kidney regions for each mouse.

    J Exp Med 2014 211(11), 2249-63. Verteporfin purchased from Selleck.

    A representative immunostaining results of p-EGFR, p-ERK, YAP1, and cleavage caspase-3 in tumors of each group of nude mice.

    Theranostics, 2017, 7(5):1114-1132. Verteporfin purchased from Selleck.

  • Colony formation in H520 cells and H1581 cells that were with or without verteporfin

    Cancer Lett, 2018, 423:36-46. Verteporfin purchased from Selleck.

    The effects of ADR and Verteporfin on the growth of HCC xenograft derived from MHCC-97H cells (n = 5 for each group). Representative images of IHC staining of KI67 and cleaved caspase-3 in tumors. Scale bar: 100 μm.

    EBioMedicine, 2018, 35:142-154. Verteporfin purchased from Selleck.

  • The indicated cell lines were treated with control (Ctrl) or YAP-targeting siRNAs and growth assessed by XTT proliferation assays at the indicated time points. The mean and +SD are shown for three independent experiments. (Left panel, *, P < 0.05, significantly different from U87Rictor DMSO; Right panel, *, P < 0.05, significantly different from H4Rictor DMSO).

    J Biol Chem, 2015, 290(32): 19387-401 . Verteporfin purchased from Selleck.

    The levels of YAP, phospho-YAP (S127), and its downstream targeted molecules CTGF and CYR61 were analyzed by Western blotting after UM cells were exposed to verteporfin for 24 hours.

    Am J Cancer Res, 2016, 6(12):2816-2830.. Verteporfin purchased from Selleck.

产品安全说明书

VDA抑制剂选择性比较

生物活性

产品描述 Verteporfin 是一种能够抑制YAP-TEAD相互作用的小分子化合物,抑制YAP诱导的肝脏过度生长。同时,它还是一种有效的衍生自卟啉的第二代光敏剂。
靶点
VDA [1]
(Endothelial cells)
YAP/TEAD interaction [3]
体外研究

对于穿透组织最好的波长(i.e.,大约700 nm)下的吸收光,Verteporfin比hematoporphyrin大约有效4倍,从而比hematoporphyrin提供了更高的细胞毒性(在人贴壁细胞中10倍以上)。Verteporfin是亲脂性的,与正常细胞或静息细胞相比,更容易被恶性的或激活的细胞摄取。Verteporfin与LDL结合形成一个复合物,随后可能通过LDL受体或者內吞作用被增殖细胞 (例如,新生血管内皮细胞) 摄取。Verteporfin疗法通过血管通道中形成血栓实现新生血管区的血管造影完全闭塞,进而引起选择性血管内皮损伤。Verteporfin疗法选择性诱导可再生的和离体的脉络膜毛细血管闭塞,而不改变覆盖的光感受器或神经节细胞,如光学和电子显微镜所示。[1] HL-60细胞中胱天蛋白酶-3和胱天蛋白酶-9的活化以及PARP的裂解映射出,光存在下,Verteporfin快速使细胞凋亡改变,该改变会被普通半胱天冬酶抑制剂ZVAD.fmk阻断。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HL-60 MoHySpVv[3Srb36gZZN{[Xl? MUf+NVAxKG6pL33M MnHmSG1UVw>? M{D4Wolv[3KnYYPld{BFVkFiZoLh[41mdnSjdHnvckBt\X[nbIO= MWixNFYxPzdzMB?=
HL-60 MoOwZ5l1d3SxeHnjbZR6KGG|c3H5 MWD+NVAxKG6pL33M NHLjZoFFVVOR M{O3OIlvcGmkaYTzJINmdGxidnnhZoltcXS7 MnH4NVA3ODd5MUC=
Jurkat MUDBdI9xfG:|aYOgZZN{[Xl? NVzhO2hDhjJ6MDDuUS=> MVzEUXNQ MVrpcoR2[2W|IHGgRoNtNTJvZHXw[Y5l\W62IHHwc5B1d3Orcx?= NX;jc3l5OTF{NEW0NVU>
RIF-1 M2rXcGZ2dmO2aX;uJIF{e2G7 MWKxJO69\y:vbB?= NUGxc4V{TE2VTx?= MUTk[YNz\WG|ZYOgc5h6\2WwIHPvcpN2dXC2aX;u NH;FcZkyOjZzNUexPC=>
RIF-1 M3;6eoN6fG:2b4jpZ4l1gSCjc4PhfS=> NFrtbGsyKM7:Zz;tcC=> NEDmSHFFVVOR NELxVGdl\WO{ZXHz[UB1dyB{MDFCtUA2LSClZXzsJJN2en[rdnHs NF;PcJkyOjZzNUexPC=>
SVEC4-10 MWjGeY5kfGmxbjDhd5NigQ>? NWDBRVBIOjByIH7nM41t MX3EUXNQ MVHpcoR2[2W|IH3pZ5JwfHWkdXzlJIRmeG:ueX3ldol7[XSrb36= NV\jXFZJOTZ2NkexNFY>
SVEC4-10 Mmn1SpVv[3Srb36gZZN{[Xl? Mlj6NlAxKG6pL33s NVnrPGJKTE2VTx?= M2LteYlv\HWlZYOgd5Rz\XO|IHHjeIlvKG[rYnXyJIZwem2jdHnvci=> NWXKXmMzOTZ2NkexNFY>
ARPE-19 MX\jfZRwfG:6aXPpeJkh[XO|YYm= NUjreFJ2hjBwMTFOwIcwdWx? NWTlc|ZTTE2VTx?= NFHjUlB{cG:5czDhJIRwe2VvZHXw[Y5l\W62IITvfIlkcXS7 MofsNVY6QDd7MEW=
ARPE-19 MUfGeY5kfGmxbjDhd5NigQ>? NIL1WVUxNjBzIN88[{9udA>? MUXEUXNQ MnzubY5kemWjc3XzJHZGT0ZiYX7kJJJm\HWlZYOgVGVFTiCneIDy[ZN{cW:w MnO0NVY6QDd7MEW=
Y-79 NVvPVVZtT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NXPXOnRzhjFizsznM41t Mm\rSG1UVw>? NWHaXJlb\GWlcnXhd4V{KHKndHnuc4Jt[XO2b33hJINmdGxicILvcIln\XKjdHnvci=> NFrkNG0yQDV5OUe2OC=>
WERI-Rb1 NXv3XJZMT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NEHzb|J,OSEQvHevcYw> M1njdGROW09? NFvHTlll\WO{ZXHz[ZMhemW2aX7vZoxie3SxbXGgZ4VtdCCycn;sbYZmemG2aX;u MWqxPFU4QTd4NB?=
RB247C3 NV7l[VN[T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= Mlu4glEh|rypL33s NYjGbYV{TE2VTx?= NEHyfY5l\WO{ZXHz[ZMhemW2aX7vZoxie3SxbXGgZ4VtdCCycn;sbYZmemG2aX;u MnHMNVg2Pzl5NkS=
RB355 NF\IV|VIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NFX2d5Z,OSEQvHevcYw> NVTpPYpGTE2VTx?= MUDk[YNz\WG|ZYOgdoV1cW6xYnzhd5RwdWFiY3XscEBxem:uaX\ldoF1cW:w MVixPFU4QTd4NB?=
RB383 M{jleGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MUP+NUDPxGdxbXy= M2\Pc2ROW09? MlPw[IVkemWjc3XzJJJmfGmwb3LsZZN1d22jIHPlcIwheHKxbHnm[ZJifGmxbh?= NHr2bVIyQDV5OUe2OC=>
hFibro M3;tdoN6fG:2b4jpZ4l1gSCjc4PhfS=> M2rMbVAvPSEEtXevcYw> M3HsW2ROW09? NIfp[IFl\WO{ZXHz[ZMhfmmjYnnsbZR6KGK7IEi2MFUm NV;WfXQ3OjN2NEGxNVQ>
pTMC NYfH[Zlw[3m2b4TvfIlkcXS7IHHzd4F6 MlfWNE42KML3Zz;tcC=> MUPEUXNQ MV\k[YNz\WG|ZYOgeoli[mmuaYT5JIJ6KDl{Lkml NEHMemQzOzR2MUGxOC=>
hTMC M2LF[4N6fG:2b4jpZ4l1gSCjc4PhfS=> MYWwMlUhyrWpL33s NGjvWHNFVVOR MoLj[IVkemWjc3XzJJZq[WKrbHn0fUBjgSB6OD65KS=> NUHCNI54OjN2NEGxNVQ>
ARPE-19 M1nJdYN6fG:2b4jpZ4l1gSCjc4PhfS=> NX;KVYZbOC53INM1[{9udA>? NGL4b|hFVVOR NV\MOGFj\GWlcnXhd4V{KH[rYXLpcIl1gSCkeTC1OU42LQ>? MXWyN|Q1OTFzNB?=
Panc-1 M1zXbWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MV[xNEDPxE1? NVewOmU6TE2VTx?= NVXJRZE5cW6qaXLpeJMh[2WubDDwdo9tcW[ncnH0bY9v MojZNlQxPjlyNkm=
MIA PaCa-2 NE\IWG9Iem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M3Pzc|ExKM7:TR?= MnjqSG1UVw>? MnnTbY5pcWKrdIOgZ4VtdCCycn;sbYZmemG2aX;u MV6yOFA3QTB4OR?=
BxPC-3 NVPBXXZiT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MmHzNVAh|ryP M2\I[WROW09? Ml62bY5pcWKrdIOgZ4VtdCCycn;sbYZmemG2aX;uJINwdXCuZYTlcJk> MWWyOFA3QTB4OR?=
SU86.86 MX3Hdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? M{n5e|ExKM7:TR?= NX7uXJdSTE2VTx?= Ml\xbY5pcWKrdIOgZ4VtdCCycn;sbYZmemG2aX;uJINwdXCuZYTlcJk> NUf2SoJYOjRyNkmwOlk>
MCF-7 NHnSPYxCfXSxcHjh[5kh[XO|YYm= NEC3[oUyOCEQvF2= NFqxZ|RFVVOR MVrpcohq[mm2czDn[Y1kcXSjYnnu[U1qdmS3Y3XkJIF2fG:yaHHnfS=> MoP0NlQxPjlyNkm=
WERI NGrwT3NIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MnnUglExKM7:Zz;tcC=> MV;EUXNQ MVnpcohq[mm2czDndo94fGhib3[gdoV1cW6xYnzhd5RwdWFiY3XscJM> M{WzNlI1QDN5MUSy
WERI MnPWSpVv[3Srb36gZZN{[Xl? MkW3glExKM7:Zz;tcC=> NWjEOVhLTE2VTx?= NYTjUIs3[myxY3vzJINmdGxiY4njcIUheHKxZ4Lld5Nqd25? MVGyOFg{PzF2Mh?=
Y-79 M2TWS2Z2dmO2aX;uJIF{e2G7 MYT+NVAh|rypL33s MVXEUXNQ MVvicI9kc3NiY3XscEBkgWOuZTDwdo9oemW|c3nvci=> MoC0NlQ5OzdzNEK=
Y-79 Mmr6SpVv[3Srb36gZZN{[Xl? M1zZc54yOCEQvHevcYw> NWjYfoRXTE2VTx?= M{i1WIFn\mWldIOgXWFRNVSHQVSgdJJwfG9vb37jc4dmdmVicHH0bJdigQ>? M1HzZ|I1QDN5MUSy
Y-79 NHTYU3NHfW6ldHnvckBie3OjeR?= MlXYglExKM7:Zz;tcC=> MYjEUXNQ M1z5ZoRwf25vcnXneYxifGW|IIDseZJqeG:2ZX7jfUBu[XKtZYKgU2NVNTR? NILZfFUzPDh|N{G0Ni=>

... Click to View More Cell Line Experimental Data

体内研究 Verteporfin可用于脉络膜血管和CNV的血管可视化,这表明光敏剂在猴子的实验性CNV中快速集聚。Verteporfin在建立的兔子眼睛的脉络膜脉管系统,RPE,以及光感受器中迅速积累。在小鼠体内,静脉注射3小时后,Verteporfin达到最大组织水平,随后在24小时内迅速下降。Verteporfin在体内代谢为活性较低的形式,并且迅速清除,主要通过粪便排泄,一小部分通过尿液排泄。Verteporfin疗法有效的选择性阻止了荧光染料从实验性诱导的猴子CNV的泄漏。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 100 mg/mL (139.12 mM)
Water Insoluble
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 718.79
化学式

C41H42N4O8

CAS号 129497-78-5
稳定性 powder
in solvent
别名 CL 318952

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03067051 Recruiting Recurrent Prostate Cancer SpectraCure AB March 21 2017 Phase 1
NCT03067051 Recruiting Recurrent Prostate Cancer SpectraCure AB March 21 2017 Phase 1
NCT03033225 Recruiting Pancreatic Cancer Non-Resectable Mayo Clinic January 5 2017 Phase 2
NCT03033225 Recruiting Pancreatic Cancer Non-Resectable Mayo Clinic January 5 2017 Phase 2
NCT02939274 Recruiting Metastatic Breast Cancer Rogers Sciences Inc. October 2016 Phase 2
NCT02939274 Recruiting Metastatic Breast Cancer Rogers Sciences Inc. October 2016 Phase 2

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操作手册

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VDA Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID