Vincristine (NSC-67574) sulfate

For research use only. Not for use in humans.

目录号:S1241 别名: Leurocristine, Oncovin, 22-Oxovincaleukoblastine 中文名称:硫酸长春新碱

Vincristine (NSC-67574) sulfate Chemical Structure

CAS No. 2068-78-2

Vincristine sulfate (NSC-67574, Leurocristine, Oncovin, 22-Oxovincaleukoblastine)通过与微管蛋白结合而抑制微管聚合,IC50为32 μM。Vincristine sulfate可诱导凋亡。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 734.41 现货
RMB 582.05 现货
RMB 2229.59 现货
RMB 7118.45 现货
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客户使用Selleck生产的Vincristine (NSC-67574) sulfate发表文献89篇:

产品安全说明书

Antineoplastic and Immunosuppressive Antibiotics抑制剂选择性比较

生物活性

产品描述 Vincristine sulfate (NSC-67574, Leurocristine, Oncovin, 22-Oxovincaleukoblastine)通过与微管蛋白结合而抑制微管聚合,IC50为32 μM。Vincristine sulfate可诱导凋亡。
靶点
Microtubules [1]
(Cell-free assay)
32 μM
体外研究

Vincristine抑制微管蛋白二聚体聚合亚单位,抑制它们的聚合作用,Ki为85 nM。[1]在低浓度时,Vincristine抑制纺锤体,使染色体分离失败,进而导致中期停滞,并抑制有丝分裂。在较高浓度时,Vincristine可能干扰且诱导全部微管解聚。[2] Vincristine 诱导肿瘤细胞凋亡,且抑制SH-SY5Y细胞增殖,IC50为0.1 µM。Vincristine诱导有丝分裂停滞,促进caspase-3和-9及cyclin B的表达,但降低cyclin D的表达。[3] Vincristine通过干扰微管功能而诱导神经毒性形成,这会导致轴突运输堵塞,从而导致轴突变性。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2.2.15 M1LOT2NmdGxiVnnhZoltcXS7IFHzd4F6 NXHPfYZqOC1yLkWg{txO MkS5NlQhcA>? NGrSdJRl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= M4f0[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nk[zO|Y6Lz5{NU[2N|c3QTxxYU6=
HepG2-HBV1.1 NHfmVotCeG:ydH;zbZMhSXO|YYm= MXewMVAvPSEQvF2= Ml3sNlQhcA>? NYm4VI9McW6mdXPld{BieG:ydH;zbZMh\G:|ZTDk[ZBmdmSnboTsfS=> NYryNldXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OlM4PjlpPkK1OlY{PzZ7PD;hQi=>
HepG2.2.15 MlH5SpVv[3Srb36gRZN{[Xl? M4DTOlAvOSEQvF2= MW[yOEBp MkHMdJJwdW:2ZYOgbIVx[XSrdHnzJGIhfmm{dYOgdJJwfGWrbjDlfJBz\XO|aX;u MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ4M{e2PUc,OjV4NkO3Olk9N2F-
HepG2-HBV1.1 MlS1SpVv[3Srb36gRZN{[Xl? MXywMlEh|ryP MonRNlQhcA>? NGLZdolxem:vb4Tld{Bp\XCjdHn0bZMhSiC4aYL1d{Bxem:2ZXnuJIV5eHKnc4Ppc44> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ4M{e2PUc,OjV4NkO3Olk9N2F-
HepG2-HBV1.1 Mni3SpVv[3Srb36gRZN{[Xl? MnrZNE4yKM7:TR?= NHzKOWU1QCCq NFLk[Ihxem:vb4Tld{Bk\WyuIHX4Z5JmfGmxbjDv[kBp\XCjdHn0bZMhSiC4aYL1d{BvfWOuZX;jZZB{cWS|IHnud5Rm[WRib3[gbIVx[XSrdHnzJGIhfmm{dYOgSIFv\SCyYYL0bYNt\XN? NHryT449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[2N|c3QSd-MkW2OlM4Pjl:L3G+
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MDA-MB-231 NUjvWVZ[SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M1XEeVQ5KGi{cx?= NFW5[XhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMUG2OkDPxE1w MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB|OEOyN{c,OjhyM{izNlM9N2F-
central nervous system cancer cells MWnDfZRwfG:6aXPpeJkh[XO|YYm= Mnz3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gZ4VvfHKjbDDu[ZJ3d3W|IIP5d5RmdSClYX7j[ZIh[2WubIOsJGdKPTBiPTCwMlEzPTh7IN88UU4> M4XUeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUm4NFE5Lz5zOEW5PFAyQDxxYU6=
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CNS NH;JZmVCdnSrdIXtc5Ih[XO|YYm= NWLSVo1vPDhiaILz MorzRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ17TJINidmOncjDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwJF0hOC5zMkW4PUDPxE1w Mny0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyME[yPFUoRjF7MEC2Nlg2RC:jPh?=
prostate cancer cells NIjQeZdCdnSrdIXtc5Ih[XO|YYm= MUG0PEBpenN? NEH5VVNCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDwdo9{fGG2ZTDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvOTJ3OEmg{txONg>? NV\FPGxDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwNFYzQDVpPkG5NFA3Ojh3PD;hQi=>
CNS MmLHRY51cXS3bX;yJIF{e2G7 NXvHN5ZZSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhS06VIIT1cY9zKGOnbHzzMEBIUTVyIE2gNE4yOjV6OTFOwG0v M2X4SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUW5NlA2Lz5zN{W1PVIxPTxxYU6=
prostate cancer cells MljERY51cXS3bX;yJIF{e2G7 MkL2RY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgdJJwe3SjdHWgeJVud3JiY3XscJMtKEeLNUCgQUAxNjF{NUi5JO69VS5? NG[1No49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W1PVIxPSd-MUe1OVkzODV:L3G+
CNS M2Ttc2FvfGm2dX3vdkBie3OjeR?= NXvmO4hLPDhiaILz NVvaO3d4SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gR25UKGOjbnPldkBk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTUA:KDBwMUOg{txONg>? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTByNkK4OUc,OTlyME[yPFU9N2F-
prostate cancer cells MXrBcpRqfHWvb4KgZZN{[Xl? MoHNOFghcHK| NITUdlFCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDwdo9{fGG2ZTDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0liPTCwMlE{KM7:TT6= NV;wWZFLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwNFYzQDVpPkG5NFA3Ojh3PD;hQi=>
prostate cancer cells M3HuUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUW0PEBpenN? NESzcolIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBxem:|dHH0[UBk[W6lZYKgZ4VtdHNiYX\0[ZIhPDhiaILzMEBIUTVyIE2gNE4yOyEQvF2u NYHYPW5iRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2PFQ2QTlpPkKwOlg1PTl7PD;hQi=>
CNS Mkn3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVzKV203PDhiaILz NEDabWVIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBEVlNiY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyxiR1m1NEA:KDBwMUOg{txONg>? MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ6NEW5PUc,OjB4OES1PVk9N2F-
CNS M325NmN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml;zOFghcHK| NWn1cGI3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS06VIHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNuIFfJOVAhRSByLkGzJO69VS5? NIXLTVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe0O|c1QSd-MkS3OFc4PDl:L3G+
prostate cancer cells MWfDfZRwfG:6aXPpeJkh[XO|YYm= NVH5N|JrPDhiaILz MYrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDwdo9{fGG2ZTDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|LDDHTVUxKD1iMD6xN{DPxE1w NVTDfWs{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3OFc4PDlpPkK0O|Q4PzR7PD;hQi=>
prostate cancer cells MmDTR5l1d3SxeHnjbZR6KGG|c3H5 NEm0NlU1QCCqcoO= Mk\nR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdJJwe3SjdHWgZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czygS2k2OCB;IECuNVMh|ryPLh?= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ6M{SzNEc,OjJ{OEO0N|A9N2F-
CNS MWnDfZRwfG:6aXPpeJkh[XO|YYm= MmPJOFghcHK| M2\pWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNPWyClYX7j[ZIh[2WubIOgZYZ1\XJiNEigbJJ{NCCJSUWwJF0hOC5zMzFOwG0v NVfXZopCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyPFM1OzBpPkKyNlg{PDNyPD;hQi=>
Melanoma cells NVzyVY5ESW62aYT1cY9zKGG|c3H5 NEXsemY1QCCqcoO= MmP6RY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTXXsZY5wdWFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFAvOTV6NEmg{txONg>? NYHnVlJURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwNFYzQDVpPkG5NFA3Ojh3PD;hQi=>
Melanoma cells M{PP[2N6fG:2b4jpZ4l1gSCjc4PhfS=> M{TTSGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJI1mdGGwb33hJINmdGy|LDDHTVUxKD1iMD6xOVg1QSEQvF2u NVezV5hkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1PVgxOThpPkG4OVk5ODF6PD;hQi=>
Melanoma cells MmrYRY51cXS3bX;yJIF{e2G7 M3zqVGFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JI1mdGGwb33hJINmdGy|LDDHTVUxKD1iMD6xOVg1QSEQvF2u M2fwblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUW5NlA2Lz5zN{W1PVIxPTxxYU6=
Melanoma cells NYjwfI5NSW62aYT1cY9zKGG|c3H5 NF3adGo1QCCqcoO= M2T1eGFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3lcIFvd22jIHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLIE2gNE4yPiEQvF2u NEe2WHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCwOlI5PSd-MUmwNFYzQDV:L3G+
Melanoma cells NF7EToNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mnm0S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gcYVt[W6xbXGgZ4VtdHNiYX\0[ZIhPDhiaILzMEBIUTVyIE2gNE4yPiEQvF2u MmrhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4OES1PVkoRjJyNki0OVk6RC:jPh?=
Melanoma cells NYLucXJrS3m2b4TvfIlkcXS7IHHzd4F6 NHfSO481QCCqcoO= NF64UoREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBu\Wyjbn;tZUBk\WyuczDh[pRmeiB2ODDodpMtKEeLNUCgQUAxNjF4IN88UU4> NEjIPHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe0O|c1QSd-MkS3OFc4PDl:L3G+
Melanoma cells MoHoR5l1d3SxeHnjbZR6KGG|c3H5 MYe0PEBpenN? M{nRfGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJI1mdGGwb33hJINmdGy|IHHmeIVzKDR6IHjyd{whT0l3MDC9JFAvOTZizszNMi=> MlHxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{OEO0N|AoRjJ{MkizOFMxRC:jPh?=
A549 NV7HZlJTSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MoDiOFghcHK| MofZRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkG3NVUh|ryPLh?= NYXEd4xvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwN|g{OjNpPkK4NFM5OzJ|PD;hQi=>
NSCLC NIr4[nlCdnSrdIXtc5Ih[XO|YYm= MlTvOFghcHK| NFixeHBCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOV2NNSyClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUSB;IECuNlUh|ryPLh?= M2q5b|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEC2Nlg2Lz5zOUCwOlI5PTxxYU6=
NSCLC MmG3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1jDR|Q5KGi{cx?= NULzSJAyT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVlOFTFOgZ4VtdHNiYX\0[ZIhPDhiaILzMEBIUTVyIE2gNE4zPSEQvF2u MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ6NEW5PUc,OjB4OES1PVk9N2F-
NSCLC MlLTR5l1d3SxeHnjbZR6KGG|c3H5 NIr1Zng1QCCqcoO= MnSwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUnNEVENiY3XscJMh[W[2ZYKgOFghcHK|LDDHTVUxKD1iMD6yOUDPxE1w MnjVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{OEO0N|AoRjJ{MkizOFMxRC:jPh?=
NSCLC MnjHR5l1d3SxeHnjbZR6KGG|c3H5 NGLwfpc1QCCqcoO= NUHjV|ZSS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVlOFTFOgZ4VtdHNiYX\0[ZIhPDhiaILzMEBIUTVyIE2gNE4zPSEQvF2u MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd2N{e0PUc,OjR5NEe3OFk9N2F-
NSCLC M1rHe2FvfGm2dX3vdkBie3OjeR?= M2TLSmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JG5US0yFIHPlcIx{NCCJSUWwJF0hOC5{NUGxPUDPxE1w NXfhbZVTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVkzODVpPkG3OVU6OjB3PD;hQi=>
NSCLC M4HKcGFvfGm2dX3vdkBie3OjeR?= MkniOFghcHK| MnPWRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTmPDUGMh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNlUyOTlizszNMi=> NHPhVHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCwOlI5PSd-MUmwNFYzQDV:L3G+
Non-small cell lung carcinoma cells M3rkcGN6fG:2b4jpZ4l1gSCjc4PhfS=> MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOc44ue22jbHygZ4VtdCCudX7nJINiemOrbn;tZUBk\WyuczygS2k2OCB;IECuNlUyOTlizszNMi=> NITnN5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW5PFAyQCd-MUi1PVgxOTh:L3G+
ovarian cancer cells MnW3R5l1d3SxeHnjbZR6KGG|c3H5 MknIR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gc5ZiemmjbjDjZY5k\XJiY3XscJMtKEeLNUCgQUAxNjNzNkKzJO69VS5? NWjHW4p6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1PVgxOThpPkG4OVk5ODF6PD;hQi=>
renal cancer cells NELVd|lEgXSxdH;4bYNqfHliYYPzZZk> NIW2UmFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBz\W6jbDDjZY5k\XJiY3XscJMtKEeLNUCgQUAxNjNzNkKzJO69VS5? NU\OU4N[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1PVgxOThpPkG4OVk5ODF6PD;hQi=>
breast cancer cells NILQfXlEgXSxdH;4bYNqfHliYYPzZZk> M1X6NWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJIJz\WG|dDDjZY5k\XJiY3XscJMtKEeLNUCgQUAxNjNzNkKzJO69VS5? MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV7OECxPEc,OTh3OUiwNVg9N2F-
ovarian cancer cells M1vqd2FvfGm2dX3vdkBie3OjeR?= NYHCNmZFPDhiaILz NHvUZmdCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDveoFzcWGwIHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNE4{OTZ{MzFOwG0v Ml[xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyME[yPFUoRjF7MEC2Nlg2RC:jPh?=
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Melanoma cells Mo\hR5l1d3SxeHnjbZR6KGG|c3H5 NG\3bVI1QCCqcoO= M12zWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJI1mdGGwb33hJINmdGy|IHHmeIVzKDR6IHjyd{whXEeLIE2gO{46PCEQvF2u MmXwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{OEO0N|AoRjJ{MkizOFMxRC:jPh?=
breast cancer cells MYjDfZRwfG:6aXPpeJkh[XO|YYm= MmPDOFghcHK| NUSwZpYxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4h[nKnYYP0JINidmOncjDj[YxteyCjZoTldkA1QCCqcoOsJHRIUSB;IEeuPVQh|ryPLh?= M1;m[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkizOFMxLz5{MkK4N|Q{ODxxYU6=
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Melanoma cells MmO0R5l1d3SxeHnjbZR6KGG|c3H5 M3L1VGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJI1mdGGwb33hJINmdGy|LDDUS2khRSB5Lkm0N|I5KM7:TT6= NEDhRpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW5PFAyQCd-MUi1PVgxOTh:L3G+
breast cancer cells MoHwR5l1d3SxeHnjbZR6KGG|c3H5 NEn0c3lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBjemWjc4SgZ4Fv[2W{IHPlcIx{NCCWR1mgQUA4Njl2M{K4JO69VS5? M4rGSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUm4NFE5Lz5zOEW5PFAyQDxxYU6=
breast cancer cells NELxTmJCdnSrdIXtc5Ih[XO|YYm= MkfpOFghcHK| NUOyWYJ{SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gRpJm[XO2IHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBVT0liPTC3Mlk1OzJ6IN88UU4> MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTByNkK4OUc,OTlyME[yPFU9N2F-
Melanoma cells M2DjfWFvfGm2dX3vdkBie3OjeR?= MoLBRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgcYVt[W6xbXGgZ4VtdHNuIGTHTUA:KDdwOUSzNlgh|ryPLh?= NX71Wo9sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVkzODVpPkG3OVU6OjB3PD;hQi=>
breast tumor cells NUDDU|FNSW62aYT1cY9zKGG|c3H5 MoPURY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgZpJm[XO2IIT1cY9zKGOnbHzzMEBVT0liPTC3Mlk1OzJ6IN88UU4> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV3OUKwOUc,OTd3NUmyNFU9N2F-
NSCLC NVjtNVZwSW62aYT1cY9zKGG|c3H5 NHT2bGpCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBPW0OOQzDj[YxteyxiVFfJJF0hOTVwOES4PUDPxE1w NVLVUWI6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVkzODVpPkG3OVU6OjB3PD;hQi=>
Leukemia cells MUHBcpRqfHWvb4KgZZN{[Xl? Moe2OFghcHK| NYTCWGF3SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUIV2c2WvaXGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiVFfJJF0hOTVwOES4PUDPxE1w M3q5[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEC2Nlg2Lz5zOUCwOlI5PTxxYU6=
NSCLC NH7keI1CdnSrdIXtc5Ih[XO|YYm= Mm\ZOFghcHK| MmjWRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTmPDUGMh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygWGdKKD1iMUWuPFQ5QSEQvF2u NWLVVpNsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwNFYzQDVpPkG5NFA3Ojh3PD;hQi=>
Non-small cell lung carcinoma cells M1\2[2N6fG:2b4jpZ4l1gSCjc4PhfS=> MWrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOc44ue22jbHygZ4VtdCCudX7nJINiemOrbn;tZUBk\WyuczygWGdKKD1iMUWuPFQ5QSEQvF2u NFjwbYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW5PFAyQCd-MUi1PVgxOTh:L3G+
Leukemia cells MnnaR5l1d3SxeHnjbZR6KGG|c3H5 MorKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gcIV2c2WvaXGgZ4VtdHNuIGTHTUA:KDF3Lki0PFkh|ryPLh?= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV7OECxPEc,OTh3OUiwNVg9N2F-
Leukemia cells MVjBcpRqfHWvb4KgZZN{[Xl? MmnjRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgcIV2c2WvaXGgZ4VtdHNuIGTHTUA:KDF3Lki0PFkh|ryPLh?= MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV3OUKwOUc,OTd3NUmyNFU9N2F-
NSCLC NY\LOFNNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF\OfnM1QCCqcoO= M2rT[Gdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG5US0yFIHPlcIx{KGGodHXyJFQ5KGi{czygWGdKKD1iMUWuPFUh|ryPLh?= M4HZVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNki0OVk6Lz5{ME[4OFU6QTxxYU6=
Leukemia cells M1P6OWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoS3OFghcHK| NEPrV3VIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBt\XWtZX3pZUBk\WyuczDh[pRmeiB2ODDodpMtKFSJSTC9JFE2Njh3IN88UU4> MmLqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4OES1PVkoRjJyNki0OVk6RC:jPh?=
NSCLC MV3DfZRwfG:6aXPpeJkh[XO|YYm= MV[0PEBpenN? Mn7IR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUnNEVENiY3XscJMh[W[2ZYKgOFghcHK|LDDUS2khRSBzNT64OUDPxE1w MmXEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{OEO0N|AoRjJ{MkizOFMxRC:jPh?=
Leukemia cells NHe2b2lEgXSxdH;4bYNqfHliYYPzZZk> M3vkXFQ5KGi{cx?= NX\0bpVmS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hdGW3a3XtbYEh[2WubIOgZYZ1\XJiNEigbJJ{NCCWR1mgQUAyPS56NTFOwG0v M13CdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{S3O|Q6Lz5{NEe0O|c1QTxxYU6=
NSCLC NUnxO2l3S3m2b4TvfIlkcXS7IHHzd4F6 MUS0PEBpenN? M1vwN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5US0yFIHPlcIx{KGGodHXyJFQ5KGi{czygWGdKKD1iMUWuPFUh|ryPLh?= NGDsZlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe0O|c1QSd-MkS3OFc4PDl:L3G+
Leukemia cells MVvDfZRwfG:6aXPpeJkh[XO|YYm= MWS0PEBpenN? M2LVS2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJIxmfWunbXnhJINmdGy|IHHmeIVzKDR6IHjyd{whXEeLIE2gNVUvQDVizszNMi=> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ6M{SzNEc,OjJ{OEO0N|A9N2F-
renal cancer cells MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUi0PEBpenN? NHT4XGNIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBz\W6jbDDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|LDDUS2khRSBzOT65OUDPxE1w NF7EdZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[4OFU6QSd-MkC2PFQ2QTl:L3G+
ovarian cancer cells NVP2[opiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4XuOlQ5KGi{cx?= M1HMfWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG93[XKrYX6gZ4Fv[2W{IHPlcIx{KGGodHXyJFQ5KGi{czygWGdKKD1iMUmuPVUh|ryPLh?= NXe2SI0zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2PFQ2QTlpPkKwOlg1PTl7PD;hQi=>
renal cancer cells MmnjR5l1d3SxeHnjbZR6KGG|c3H5 MonkOFghcHK| NF;KOoJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBz\W6jbDDjZY5k\XJiY3XscJMh[W[2ZYKgOFghcHK|LDDUS2khRSBzOT65OUDPxE1w NHPJcms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe0O|c1QSd-MkS3OFc4PDl:L3G+
ovarian cancer cells MX7DfZRwfG:6aXPpeJkh[XO|YYm= NFnVTpA1QCCqcoO= NF7lfVlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBwfmG{aXHuJINidmOncjDj[YxteyCjZoTldkA1QCCqcoOsJHRIUSB;IEG5Mlk2KM7:TT6= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd2N{e0PUc,OjR5NEe3OFk9N2F-
renal cancer cells MX3DfZRwfG:6aXPpeJkh[XO|YYm= MVK0PEBpenN? M3jEcGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJJmdmGuIHPhcoNmeiClZXzsd{Bi\nSncjC0PEBpenNuIGTHTUA:KDF7Lkm1JO69VS5? NFG4SXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK4N|Q{OCd-MkKyPFM1OzB:L3G+
ovarian cancer cells M{PIO2N6fG:2b4jpZ4l1gSCjc4PhfS=> MnLwOFghcHK| NFey[3NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBwfmG{aXHuJINidmOncjDj[YxteyCjZoTldkA1QCCqcoOsJHRIUSB;IEG5Mlk2KM7:TT6= NW\mUnB2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyPFM1OzBpPkKyNlg{PDNyPD;hQi=>
ovarian cancer cells M{DVOWN6fG:2b4jpZ4l1gSCjc4PhfS=> NHXWcGFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBwfmG{aXHuJINidmOncjDj[YxteyxiVFfJJF0hOTlwOUWyOkDPxE1w NYHae2xvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1PVgxOThpPkG4OVk5ODF6PD;hQi=>
renal cancer cells NETmXYdEgXSxdH;4bYNqfHliYYPzZZk> MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDy[Y5idCClYX7j[ZIh[2WubIOsJHRIUSB;IEG5Mlk2OjZizszNMi=> NYftU29qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1PVgxOThpPkG4OVk5ODF6PD;hQi=>
ovarian cancer cells NFjlc2tCdnSrdIXtc5Ih[XO|YYm= NU\nSZNbPDhiaILz M4rhfGFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIH;2ZZJq[W5iY3HuZ4VzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJHRIUSB;IEG5Mlk2OjZizszNMi=> MkixQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyME[yPFUoRjF7MEC2Nlg2RC:jPh?=
renal cancer cells M1;YVWFvfGm2dX3vdkBie3OjeR?= M{CwRVQ5KGi{cx?= MkHvRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5icnXuZYwh[2GwY3XyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIGTHTUA:KDF7Lkm1NlYh|ryPLh?= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTByNkK4OUc,OTlyME[yPFU9N2F-
renal tumor cells MkG4RY51cXS3bX;yJIF{e2G7 MXjBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDy[Y5idCC2dX3vdkBk\WyuczygWGdKKD1iMUmuPVUzPiEQvF2u NUfOXWU5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OVkzODVpPkG3OVU6OjB3PD;hQi=>
ovarian tumor cells M3zxeWFvfGm2dX3vdkBie3OjeR?= M3;S[mFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JI93[XKrYX6geJVud3JiY3XscJMtKFSJSTC9JFE6Njl3Mk[g{txONg>? NFKxZYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W1PVIxPSd-MUe1OVkzODV:L3G+
PC3 NW\YXnBSS3m2b4TvfIlkcXS7IHHzd4F6 NXX2bIR6PDhiaILz MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjhwMUGg{txONg>? MmLnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzN{S4NVYoRjJ7MUe0PFE3RC:jPh?=
neural precursor cells MlrZSpVv[3Srb36gZZN{[Xl? NYDjVHBSUW6qaXLpeIlwdiCxZjDu[ZVzd3OyaHXy[UBxem:uaX\ldoF1cW:wIH;mJI1wfXOnIH7leZJidCCycnXjeZJ{d3JiY3XscJMh[nliTWTUJIF{e2G7 NE\mOGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SxO|Y{OSd-MUe0NVc3OzF:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
MPM2 / Cyclin B1 / Cdc25c / p-Cdc2 / Cdc2 / Aurora B / p-H3 / p-PLK1; 

PubMed: 26156322     


MOLT-4 Cells were treated with vincristine (0.3, 1, and 3 nM) alone or co-treated with SAHA (500 nM) for 24 h. Then, total cell lysates were obtained to evaluate the G2/M phase regulatory protein expression and the tubulin acetylation. Data are expressed as mean values ± SD of at least three separate determinations. S SAHA, V vincristine

26156322
Growth inhibition assay
Cell viability ; 

PubMed: 26156322     


MOLT-4 cells were treated with various concentrations of vincristine for 24 and 48 h, respectively.  Cell viability was measured by MTT assay.

26156322
体内研究 Vincristine 按3 mg/kg剂量单独腹腔注射给药携带双侧皮下移植瘤RH12或RH18的小鼠,平均生长延迟120天和52天以上,且再植指数分别为0.06%和5%。[5] Vincristine 处理小鼠,通过宿主细胞介导的血管效应及直接的微管蛋白介导的的细胞毒性作用而对皮下结肠38肿瘤起作用。Vincristine (5 mg/kg) 降低肿瘤血流量,降低近75%。[6]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[1]
- 合并
  • Cell lines: B16 黑色素瘤细胞
  • Concentrations: 10 nM
  • Incubation Time: 3 天
  • Method: 细胞按5 × 104 cells/mL的浓度接种在含2 mL培养基的35-mm 实验板上,在37°C下 含5% CO2 和95% 空气 的环境下生长24小时。然后使用有或无10 nM药物的新鲜培养基更换原来的培养基,继续增殖3天。使用胰蛋白酶和EDTA将细胞分离后,每天使用库氏计数器完成细胞计数
    (Only for Reference)
动物实验:[5]
- 合并
  • Animal Models: 携带人类横纹肌肉瘤移植瘤Rh12的鼠
  • Dosages: 3 mg/kg
  • Administration: 腹腔注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (108.33 mM)
Water 60 mg/mL (65.0 mM)
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
Saline
30 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 923.04
化学式

C46H58N4O14S

CAS号 2068-78-2
储存条件 粉状
溶于溶剂
别名 Leurocristine, Oncovin, 22-Oxovincaleukoblastine

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04448834 Not yet recruiting Drug: Blinatumomab B-cell Acute Lymphoblastic Leukemia David Rizzieri MD|Amgen|Acrotech Biopharma LLC|Duke University April 1 2021 Phase 2
NCT03981510 Recruiting Diagnostic Test: 3D-Transit Constipation|Childhood Acute Lymphoblastic Leukemia|Neurofibromatosis 1|Chronic Constipation With Overflow University of Aarhus June 13 2019 Not Applicable

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    I want to use the product #S1421 for mouse in vivo, could you please give us your advice about administration method?

  • 回答:

    According to the reference cited on our website, we test the solubility of S1421 Staurosporine in 4% DMSO/saline, and it is a suspension at 5 mg/mL. The compound can also be dissolved in the vehicle 4% DMSO/30% PEG 300/10% Tween 80/saline at 5 mg/ml as a clear solution for injection.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID