GW3965 HCl

For research use only. Not for use in humans.

目录号:S2630

GW3965 HCl Chemical Structure

CAS No. 405911-17-3

GW3965 HCl是一种有效的,选择性LXR激动剂,作用于hLXRα和hLXRβ,无细胞试验中EC50分别为190和30 nM。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1966.57 现货
RMB 790.51 现货
RMB 4654.57 现货
RMB 9746.1 现货
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客户使用Selleck生产的GW3965 HCl发表文献28篇:

产品安全说明书

Liver X Receptor抑制剂选择性比较

生物活性

产品描述 GW3965 HCl是一种有效的,选择性LXR激动剂,作用于hLXRα和hLXRβ,无细胞试验中EC50分别为190和30 nM。
靶点
hLXRβ [1]
(Cell-free assay)
LXRα/SRC1 LiSA [1]
(Cell-free assay)
hLXRα [1]
(Cell-free assay)
30 nM(EC50) 125 nM(EC50) 190 nM(EC50)
体外研究

GW3965使类固醇受体共激活因子1聚集到LXRα,在无细胞配体检测试验中,EC50 为125 nM。[1] GW3965对hLXRα 和 hLXRβ表现出有效的拮抗活性,在细胞试验中EC50分别为190 nM 和30 nM。此外,GW3965也对其他核受体表现出优良的选择性。[1]在人胰岛中,GW3965 (1 μM)降低选定促炎性细胞因子,包括IL-8,单核细胞趋化蛋白-1和组织因子的表达。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 MYOxNEB2VQ>? MlHzNlAhcHK| NEPvOXZC[3SrdnH0bY9vKG:oIHj1cYFvKEy[UnHsdIhiKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[29vZYjwdoV{e2mwZzDoeY1idiCUWGLhcJBp[SCjdDCxNEB2VSCjZoTldkAzOCCqcoOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7 NFjQfmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECwOlkxQSd-MkiwNFY6ODl:L3G+
HEK293 M1no[lExKHWP MoXPNlAhcHK| MYHBZ5RqfmG2aX;uJI9nKHKjdDDMXHJj\XSjIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiY3:t[ZhxemW|c3nu[{BpfW2jbjDSXHJidHCqYTDheEAyOCC3TTDh[pRmeiB{MDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5 NFnKPHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECwOlkxQSd-MkiwNFY6ODl:L3G+
THP1 NEjsVGNHfW6ldHnvckBie3OjeR?= MorITY5lfWO2aX;uJI9nKGOqb3zld5Rmem:uIHXm[ox2gCCrbjDUTHAyKGOnbHzzMEBGSzVyIE2gNE4xOSEQvF2u NFWwdZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W4O|U4Oyd-MUe1PFc2PzN:L3G+
THP1 NXnoWoIxTnWwY4Tpc44h[XO|YYm= M1jVSlE5KGi{cx?= NVqybFVCUW6mdXP0bY9vKG:oIHPoc4xme3Sncn;sJIVn\my3eDDpckBVUFBzIHPlcIx{KGGodHXyJFE5KGi{czygSWM2OCB;IECuNFEh|ryPLh?= M{nHS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG2OVIyLz5zN{SxOlUzOTxxYU6=
COS7 MUTGeY5kfGmxbjDhd5NigQ>? M2HCTlE3KGi{cx?= MljrRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDMXHJj\XSjIILlZ4VxfG:{IITyZY5{\mWldHXkJIlvKEORU{egZ4VtdHNiYX\0[ZIhOTZiaILzJIJ6KHKncH;yeIVzKHS{YX7zZYN1cX[jdHnvckBie3OjeTygSWM2OCB;IECuNFE2KM7:TT6= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV6N{W3N{c,OTd3OEe1O|M9N2F-
COS7 NI\FOHhHfW6ldHnvckBie3OjeR?= NFLtS|BC[3SrdnH0bY9vKG:oIFzYVoJmfGFiY3:teJJidnOoZXP0[YQhcW5iQ1;TO{Bk\WyuczD3bZRpKFK[UnHsdIhiKGK7IILldI9zfGW{IITyZY5{[WO2aY\heIlwdiCjc4PhfUwhTUN3MDC9JFAvODF3IN88UU4> M4naVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG2OVIyLz5zN{SxOlUzOTxxYU6=
THP1 M3;iXWFvfGmrbn\sZY1u[XSxcomgZZN{[Xl? NFnT[mM3KGi{cx?= MVnBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHHnZYlve3RiaIXtZY4hXEiSMTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJGlNPiCycn;keYN1cW:wIHHmeIVzKDZiaILzJIJ6KEWOSWPBMEBKSzVyIE2gNE4xOiEQvF2u NUjVdY9nRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4NFA4PjdpPkG4PFAxPzZ5PD;hQi=>
THP1 NFnwSY5HfW6ldHnvckBie3OjeR?= MnLzRYdwdmm|dDDhZ5Rqfmm2eTDheEBISUxvbHnub4VlKGi3bXHuJGxZWmKndHGg[ZhxemW|c3XkJIlvKFSKUEGgZ4VtdHNiYYPz[ZN{\WRiYYOgd5RqdXWuYYTpc44hd2ZiY3:tZYN1cX[jdH;yJJJm[3K3aYTt[Y51KGK7IF\SSXQh[XO|YYmsJGVEPTBiPTCwMlAzPyEQvF2u NEfOb4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[2OVg6Pyd-MUe2OlU5QTd:L3G+
RAW264.7 MULGeY5kfGmxbjDhd5NigQ>? M1vUblI1KGi{cx?= NW[1UJk1UW6mdXP0bY9vKG:oIGuzTH1kcG:uZYP0[ZJwdCCnZn\seZghcW5ibX;1d4UhWkGZMk[0Mlch[2WubIOgcI9i\GWmIIfpeIgh[WOndInsZZRm\C2ORFygZYZ1\XJiMkSgbJJ{NCCHQ{WwJF0hOC5yMkmg{txONg>? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTdzN{OwOEc,OTl5MUezNFQ9N2F-
THP1 MU\GeY5kfGmxbjDhd5NigQ>? M2DvNnN1cW23bHH0bY9vKG:oIGuzTH1kcG:uZYP0[ZJwdCCnZn\seZghcW5iaIXtZY4hXEiSMTDmc4FuKGOnbHzzJIxw[WSnZDD3bZRpKGGlLVzEUEwhTUN3MDC9JFAvODNzIN88UU4> MnyxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7N{OyPFgoRjF6OUezNlg5RC:jPh?=
CV1 NGP6eZRHfW6ldHnvckBie3OjeR?= NYfkc2hySW62YXfvcol{fCCjY4Tpeol1gSCjdDDMXHJj\XSjIHzp[4Fv\CCkaX7kbY5oKGSxbXHpckBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJHQyOzF5LXnu[JVk\WRidILhcpNkemmydHnvcoFtKGGldHn2bZR6KGmwIHHmdolk[W5iZ4Ll[Y4hdW:wa3X5JGNXOSClZXzsd{Bkdy22cnHud4Zm[3SnZDD3bZRpKEejbEStV3JEOSCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIF{e2G7LDDJR|UxKD1iMD6wN|k5OSEQvF2u M2fyeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{S1NVAzLz5{MEO0OVExOjxxYU6=
THP1 NVzuSW0xTnWwY4Tpc44h[XO|YYm= NXryZW91SWexbnnzeEBi[3Srdnn0fUBifCCJQVytcIlvc2WmIHj1cYFvKEy[UnHsdIhiKGW6cILld5Nm\CCrbjDUTHAyKGOnbHzzJIF{e2W|c3XkJIF{KHO2aX31cIF1cW:wIH;mJINw[WO2aY\heI9zKHKnY4L1bZRu\W62IHL5JGZTTVRiYYPzZZktKEWFNUCgQUAxNjB7NzFOwG0v M{\BVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nk[1PFk4Lz5zN{[2OVg6PzxxYU6=
CV1 M{HQUWZ2dmO2aX;uJIF{e2G7 M33ZUmFvfGGpb37pd5Qh[WO2aY\peJkh[XRiTGjSZYxxcGFibHnnZY5lKGKrbnTpcoch\G:vYXnuJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gWFE{OTdvaX7keYNm\CC2cnHud4NzcXC2aX;uZYwh[WO2aY\peJkhcW5iYX\ybYNidiCpcnXlckBud26tZYmgR3YyKGOnbHzzJINwNXS{YX7z[oVkfGWmIIfpeIghT2GuND3TVmMyKGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKgZZN{[XluIFnDOVAhRSByLkGg{txONg>? M1j6[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{S1NVAzLz5{MEO0OVExOjxxYU6=
SH-SY5Y M1;YdmZ2dmO2aX;uJIF{e2G7 NWL4cVhiOjRiaILz NIPtWIxC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJGxZWmKndHGg[ZhxemW|c3XkJIlvKGi3bXHuJHNJNVO\NWmgZ4VtdHNiY3:teJJidnOoZXP0[YQhf2m2aDDHZYw1NUyERDDh[pRmeiB{NDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyIE2gNE4yOyEQvF2u MkiwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{NkS0PFEoRjF7Mk[0OFgyRC:jPh?=
HepG2 M37RS2Z2dmO2aX;uJIF{e2G7 NWS2bndrTW[oZXP0JI9vKFOURVLQNYMh\2WwZTDlfJBz\XO|aX;uJIlvKGi3bXHuJGhmeEd{IHPlcIx{NCCHQ{WwJF0hOC5{MTFOwG0v MnfCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7N{OyPFgoRjF6OUezNlg5RC:jPh?=
HuH7 MVfGeY5kfGmxbjDhd5NigQ>? MnzmRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDy[YNwdWKrbnHueEBNYFKkZYThJIxq\2GwZDDibY5lcW6pIHTvcYFqdiCrbjDoeY1idiCKdVi3JINmdGy|IHPvMZRz[W6|ZnXjeIVlKHerdHig[pV{\WRiR3HsOE1FSkRiYomgeJJidnOjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwJF0hOC5|MTFOwG0v NV\vSGZnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5O|MzQDhpPkG4PVc{Ojh6PD;hQi=>
SH-SY5Y NIHSZ4NHfW6ldHnvckBie3OjeR?= MmD6NlQhcHK| NY\z[WxjSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBNYFKjbIDoZUBmgHC{ZYPz[YQhcW5iaIXtZY4hW0hvU2m1XUBk\WyuczDjc{11emGwc3\lZ5Rm\CC5aYToJGdidDRvTFLEJIFnfGW{IEK0JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUCgQUAxNjNzIN88UU4> MnvZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{NkS0PFEoRjF7Mk[0OFgyRC:jPh?=
CHO M3vITGZ2dmO2aX;uJIF{e2G7 NX;VcZpCSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBNYFJiYnX0ZUBz\WOncITvdkBmgHC{ZYPz[YQhcW5iQ1jPJINmdGy|IHL5JJJmeG:{dHXyJIF{e2G7LDDFR|UxKD1iMD60NUDPxE1w MlvaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyM{SxNVkoRjF5MEO0NVE6RC:jPh?=
CHOK1 NUPjSYJtTnWwY4Tpc44h[XO|YYm= MnPsNlQhcHK| MkHaRYdwdmm|dDDhZ5Rqfmm2eTDheEBI[Wx2LYTh[4dm\CCOWGLi[ZRiKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIFPIU2syKGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUCgQUAxNjR{IN88UU4> M2q5U|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nke3OlY1Lz5{NU[3O|Y3PDxxYU6=
THP1 M4LjZWZ2dmO2aX;uJIF{e2G7 MmK3SYZn\WO2IH;uJGFDS0FzIHflcoUh\XiycnXzd4lwdiCrbjDoeY1idiCmaX\m[ZJmdnSrYYTl[EBVUFBzIHPlcIx{NCCHQ{WwJF0hOC52M{Sg{txONg>? NXzoV3ZwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5O|MzQDhpPkG4PVc{Ojh6PD;hQi=>
CV1 MnHOSpVv[3Srb36gZZN{[Xl? NEPqUnhC\2:waYP0JIFkfGm4aYT5JIF1KEy[UnLleIEhdGmpYX7kJIJqdmSrbneg[I9u[WmwLX3l[IlifGWmIITyZY5{[3KrcITpc45idCCjY4Tpeol1gSCrbjDh[pJq[2GwIHfy[YVvKG2xbnvlfUBEXjFiY3XscJMh[29vdILhcpNn\WO2ZXSge4l1cCCJYXy0MXNTSzFiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBie3OjeTygSWM2OCB;IECuOVAyOTlizszNMi=> NFHqVYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO0OVExOid-MkCzOFUyODJ:L3G+
HuH7 M1LBUWZ2dmO2aX;uJIF{e2G7 NVzEVHFSSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBz\WOxbXLpcoFvfCCOWGLhcJBp[SCuaXfhcoQh[mmwZHnu[{Bld22jaX6gbY4hcHWvYX6gTJVJPyClZXzsd{Bkdy22cnHud4Zm[3SnZDD3bZRpKG[3c3XkJGdidDRvRFLEJIJ6KHS{YX7zZYN1cX[jdHnvckBie3OjeTygSWM2OCB;IECuOlYh|ryPLh?= NXjjZYVrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5O|MzQDhpPkG4PVc{Ojh6PD;hQi=>
CV1 MmLDSpVv[3Srb36gZZN{[Xl? M4PW[GFod26rc4SgZYN1cX[rdImgZZQhVFiUYXzwbIEhdGmpYX7kJIJqdmSrbneg[I9u[WmwLX3l[IlifGWmIITyZY5{[3KrcITpc45idCCjY4Tpeol1gSCrbjDh[pJq[2GwIHfy[YVvKG2xbnvlfUBEXjFiY3XscJMh[29vdILhcpNn\WO2ZXSge4l1cCCJYXy0MXNTSzFiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBie3OjeTygSWM2OCB;IECuO|k1OzNizszNMi=> NYrYc2EzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOFUyODJpPkKwN|Q2OTB{PD;hQi=>
CHOK1 NG\ZUGdHfW6ldHnvckBie3OjeR?= NXjRNoNyOjRiaILz M37ROmFod26rc4SgZYN1cX[rdImgZZQhT2GuND30ZYdo\WRiTGjSZYxxcGFiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gR2hQUzFiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NEA:KDFwMzFOwG0v NHnVSJU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[3O|Y3PCd-MkW2O|c3PjR:L3G+
HepG2 Mkf0SpVv[3Srb36gZZN{[Xl? MX7F[oZm[3Rib36geJJq\2y7Y3XybYRmKGGlY4XteYxifGmxbjDpckBpfW2jbjDI[ZBIOiClZXzsd{whTUN3MDC9JFIvODB{IN88UU4> MlzSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7N{OyPFgoRjF6OUezNlg5RC:jPh?=
HepG2 NHHVT4xHfW6ldHnvckBie3OjeR?= MV21NFAhdk1? NHnEWYpKdmirYnn0bY9vKG:oIEKtLFMuMDNvKDiyMYNpdG:{bz2zMUh1emmobIXvdo9u\XSqeXypZoVvgnmuKTiyMFIu\GmyaHXufYxmfGi7bDnhcYlvdymycn;wc5h6MXCqZX75cEli[2W2aXOgZYNq\C2rbnT1Z4VlKHO{ZXLwNYMhdVKQQTDlfJBz\XO|aX;uJIlvKGi3bXHuJGhmeEd{IHPlcIx{KGG2IEWwNEBvVQ>? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDhyMEe2O{c,OTh6MEC3Olc9N2F-
HepG2 MlzLSpVv[3Srb36gZZN{[Xl? NXTaRpp4PTByIH7N Ml;XTY5pcWKrdHnvckBw\iB{LTizMUg{NShqMj3jbIxwem9vMz2oeJJq\my3b4LvcYV1cHmuKXLlcpp6dClqMjyyMYRqeGinbons[ZRpgWxrYX3pco8qeHKxcH;4fUlxcGWweXypZYNmfGmlIHHjbYQucW6mdXPl[EBn[XNibWLORUBmgHC{ZYPzbY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHH0JFUxOCCwTR?= Mmm4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh6MEC3OlcoRjF6OECwO|Y4RC:jPh?=
RAW264.7 NVPVPIpqTnWwY4Tpc44h[XO|YYm= MnPONUB2VQ>? NYHucnVbWmWmdXP0bY9vKG:oIFzQV{1{fGmvdXzheIVlKGmQT2Og[4Vv\SCneIDy[ZN{cW:wIHnuJI1wfXOnIGLBW|I3PC55IHPlcIx{KGW6cILld5NqdmdiTGjSZYxxcGFiYYSgNUB2VSCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZk> NGTj[449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEiwNFc3Pyd-MUi4NFA4Pjd:L3G+
RAW264.7 NX;CSpFpTnWwY4Tpc44h[XO|YYm= MmOyNUB2VQ>? MlTxTY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBvfWOuZXHyJINwNXKncILld5NweiC{ZXzlZZNmKG[{b32gbW5QWyCycn;tc5RmeiCrbjDtc5V{\SCUQWeyOlQvPyClZXzsd{BifCBzIIXNJIJ6KFKWLWDDVi=> NGHN[no9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEiwNFc3Pyd-MUi4NFA4Pjd:L3G+
HeLa NH\WWIdHfW6ldHnvckBie3OjeR?= NGnl[HgyKHWP MUTJcoR2[3Srb36gc4YhVFiUYnX0ZUBUXU2ReXzheIlwdiCkeTDTWW1QOiCrbjDoeY1idiCKZVzhJINmdGy|IHH0JFEhfU1iYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ M{C2T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OECwO|Y4Lz5zOEiwNFc3PzxxYU6=
HeLa MlzpSpVv[3Srb36gZZN{[Xl? MlrGNUB2VQ>? NX75cVkyUW6mdXP0bY9vKG:oIFzYVoJmfGFiU2XNU5lt[XSrb36gZpkhW1WPT{OgbY4hcHWvYX6gTIVN[SClZXzsd{BifCBzIIXNJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= NHLpeJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEiwNFc3Pyd-MUi4NFA4Pjd:L3G+
HeLa M2DBZmZ2dmO2aX;uJIF{e2G7 MnXwNUB2VQ>? M2PCTGlv\HWldHnvckBw\iCOWGLhcJBp[SCVVV3PfYxifGmxbjDifUBUXU2RMzDpckBpfW2jbjDI[WxiKGOnbHzzJIF1KDFidV2gZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| NVPrSFFrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4NFA4PjdpPkG4PFAxPzZ5PD;hQi=>
DAOY NYXURWlNeUiWUzDhd5NigQ>? MWnxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhTEGRWTDj[Yxtew>? MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
SJ-GBM2 NYXkVZJueUiWUzDhd5NigQ>? NIK2NHFyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1qtS2JOOiClZXzsdy=> NHXaclU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
A673 NWWwZVk5eUiWUzDhd5NigQ>? MVHxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhSTZ5MzDj[Yxtew>? MkPqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SK-N-MC MnfTdWhVWyCjc4PhfS=> NXHE[ZlbeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGPLMW4uVUNiY3XscJM> NEXlfG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
BT-37 NXXlbpBGeUiWUzDhd5NigQ>? MonzdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKEKWLUO3JINmdGy| MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
NB-EBc1 MXjxTHRUKGG|c3H5 M3fPSZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCQQj3FRoMyKGOnbHzz MnTZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SK-N-SH NInBfGRyUFSVIHHzd4F6 NHnHfGdyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1UUCClZXzsdy=> NEfvSpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
BT-12 NH7t[5NyUFSVIHHzd4F6 M{PHXpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCEVD2xNkBk\Wyucx?= MlfTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
OHS-50 M3PVe5FJXFNiYYPzZZk> NGnJdI5yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiT1jTMVUxKGOnbHzz NFPMdWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
RD NHzu[WtyUFSVIHHzd4F6 NH3V[lhyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiUlSgZ4VtdHN? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
MG 63 (6-TG R) M1X0VJFJXFNiYYPzZZk> MULxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVUdiNkOgLFYuXEdiUjmgZ4VtdHN? MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
Rh30 MVvxTHRUKGG|c3H5 NHHvOpByUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiUnizNEBk\Wyucx?= M3PURVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Rh41 MnvGdWhVWyCjc4PhfS=> NUT0PINveUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGLoOFEh[2WubIO= NX\4bpJWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Skp2 / pEGFR / EGFR / pERK / ERK ; 

PubMed: 25184494     


GW3965 treatment downregulates SKP2 and EGFR protein levels in BxPC-3 and MIA-PaCa-2 cells. Downregulation of EGFR was concomitant with a downregulation of its own phosphorylation in BxPC-3 and MIA-PaCa-2 at 5 uM GW 3965. ERK1/2 and its phosphorylation were not statistically different in any of the cell lines.

LXRα / LXRβ / ABCA1 / ABCG1; 

PubMed: 11604492     


Differentiated THP-1 macrophages were incubated for 48 h in RPMI medium plus 10% LPDS, Oxysterols [20(S)HC, 22(R)HC, or 22(S)HC, 2.0 μg/ml], synthetic LXR ligand (GW3965 or T1317, 0.1 to 10.0 μM), or RXR ligand (LG268, 50 nM).

25184494 11604492
Immunofluorescence
LAMP-1 / LDLR; 

PubMed: 23382078     


HeLa cells were cultured in 10% LPDS medium for 8 h and then treated with GW3965 (1 μM) for the indicated times. Cells were immunostained with LDLR and LAMP-1 antibodies. Nuclei were counterstained with DAPI (blue). Representative confocal images are shown. T, time; O/N, overnight.

pRelA ; 

PubMed: 26635040     


Freshly isolated PDC (plasmacytoid dendritic cells) were treated for 24 h with 1 mM of GW3965 (GW), followed by TLR7 ligand, R848 (1 mg/mL) for 45 min. Phosphorylation of the NF-κB p65 (pRelA) subunit and its cellular localization were evaluated by confocal microscopy analysis. Results from a representative experiment out of 3 using PDC from 3 different donors.

23382078 26635040
Growth inhibition assay
Cell viability; 

PubMed: 25184494     


A, B, C, PDAC cells (BxPC-3, Mia-PaCa-2, and PANC-1 cell lines, respectively) show dose-dependent decreases in cell proliferation upon treatment with increasing GW3965 concentrations. EC50 calculations indicate that BxPC-3 and Mia-PaCa-2 cells are more sensitive to ligand treatment than PANC-1 cells. 

25184494
体内研究 在小鼠体内,GW3965在10 mg/kg剂量下使ABCA1表达上调8倍,并使循环水平提高30%,Cmax为12.7 μg/mL ,t1/2为2小时。[1] 在LDLR−/−和apoE−/−小鼠体内,GW3965 (10mg/kg)诱导ABCA1 和ABCG1表达,并表现出有效的抗动脉粥样硬化活性。[2]在雄性sprague-dawley大鼠体内,GW3965降低Ang II介导的血压增加,并减少血管Ang II受体基因表达。[3]在恶性胶质瘤小鼠模型中,GW3965导致LDLR降解,增加ABCA1胆固醇外排转运体的表达,从而有效促进肿瘤细胞死亡。[5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

动物实验:[1]
- 合并
  • Animal Models: C57BL/6 小鼠
  • Dosages: ≤10 mg/kg
  • Administration: 口服
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 16 mg/mL warmed (25.86 mM)
Water Insoluble
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 618.51
化学式

C33H31ClF3NO3.HCl

CAS号 405911-17-3
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    How to formulate the compound for mouse in vivo experiment?

  • 回答:

    S2630 GW3965 HCl can be dissolved in 2% DMSO/30% PEG 300/dd H2O at 10 mg/mL as a homogeneous suspension. This vehicle is suitable for oral gavage to mice.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID