GW3965 HCl

目录号:S2630

仅限科研使用

GW3965 HCl是一种有效的,选择性LXR激动剂,作用于hLXRα和hLXRβ,无细胞试验中EC50分别为190和30 nM。

GW3965 HCl Chemical Structure

CAS: 405911-17-3

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 1966.57 现货
RMB 790.51 现货
RMB 4654.57 现货
大包装 有超大折扣

今日订购,明日送达 全国免运费 分装免费 分装成小规格产品(单支最小为1mg)
如1支10mg产品可分装为10支1mg产品

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的GW3965 HCl发表文献34篇:

产品安全说明书

Liver X Receptor抑制剂选择性比较

相关Liver X Receptor产品

生物活性

产品描述 GW3965 HCl是一种有效的,选择性LXR激动剂,作用于hLXRα和hLXRβ,无细胞试验中EC50分别为190和30 nM。
靶点
hLXRβ [1]
(Cell-free assay)
LXRα/SRC1 LiSA [1]
(Cell-free assay)
hLXRα [1]
(Cell-free assay)
30 nM(EC50) 125 nM(EC50) 190 nM(EC50)
体外研究

GW3965使类固醇受体共激活因子1聚集到LXRα,在无细胞配体检测试验中,EC50 为125 nM。[1] GW3965对hLXRα 和 hLXRβ表现出有效的拮抗活性,在细胞试验中EC50分别为190 nM 和30 nM。此外,GW3965也对其他核受体表现出优良的选择性。[1]在人胰岛中,GW3965 (1 μM)降低选定促炎性细胞因子,包括IL-8,单核细胞趋化蛋白-1和组织因子的表达。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 MVuxNEB2VQ>? MX6yNEBpenN? NES0[GZC[3SrdnH0bY9vKG:oIHj1cYFvKEy[UnHsdIhiKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[29vZYjwdoV{e2mwZzDoeY1idiCUWGLhcJBp[SCjdDCxNEB2VSCjZoTldkAzOCCqcoOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7 NUjSVnBWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwNFY6ODlpPkK4NFA3QTB7PD;hQi=>
HEK293 NEPteokyOCC3TR?= MWKyNEBpenN? NGHmW|JC[3SrdnH0bY9vKG:oIILheEBNYFKkZYThJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZ48u\XiycnXzd4lv\yCqdX3hckBTYFKjbIDoZUBifCBzMDD1UUBi\nSncjCyNEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6 Mly3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyME[5NFkoRjJ6MEC2PVA6RC:jPh?=
THP1 NXXKVG1mTnWwY4Tpc44h[XO|YYm= MnjwTY5lfWO2aX;uJI9nKGOqb3zld5Rmem:uIHXm[ox2gCCrbjDUTHAyKGOnbHzzMEBGSzVyIE2gNE4xOSEQvF2u M1fDOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUi3OVc{Lz5zN{W4O|U4OzxxYU6=
THP1 Ml31SpVv[3Srb36gZZN{[Xl? M4LkeVE5KGi{cx?= MV;JcoR2[3Srb36gc4Yh[2ixbHXzeIVzd2xiZX\mcJV5KGmwIGTIVFEh[2WubIOgZYZ1\XJiMUigbJJ{NCCHQ{WwJF0hOC5yMTFOwG0v MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzNkWyNUc,OTd2MU[1NlE9N2F-
COS7 NXfWUYJVTnWwY4Tpc44h[XO|YYm= MV6xOkBpenN? NHrQSlNC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJGxZWmKndHGgdoVk\XC2b4KgeJJidnOoZXP0[YQhcW5iQ1;TO{Bk\WyuczDh[pRmeiBzNjDodpMh[nlicnXwc5J1\XJidILhcpNi[3SrdnH0bY9vKGG|c3H5MEBGSzVyIE2gNE4xOTVizszNMi=> MljWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3OEe1O|MoRjF5NUi3OVc{RC:jPh?=
COS7 MXvGeY5kfGmxbjDhd5NigQ>? MWnBZ5RqfmG2aX;uJI9nKEy[UnLleIEh[29vdILhcpNn\WO2ZXSgbY4hS0:VNzDj[YxteyC5aYToJHJZWmGucHjhJIJ6KHKncH;yeIVzKHS{YX7zZYN1cX[jdHnvckBie3OjeTygSWM2OCB;IECuNFE2KM7:TT6= NHjVWXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SxOlUzOSd-MUe0NVY2OjF:L3G+
THP1 NFPnbo5CdnSraX7mcIFudWG2b4L5JIF{e2G7 M2fnRVYhcHK| Mn[wRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFSKUEGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBKVDZicILv[JVkfGmxbjDh[pRmeiB4IHjyd{BjgSCHTFnTRUwhUUN3MDC9JFAvODJizszNMi=> M1vB[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OECwO|Y4Lz5zOEiwNFc3PzxxYU6=
THP1 MVjGeY5kfGmxbjDhd5NigQ>? MVnB[49vcXO2IHHjeIl3cXS7IHH0JGdCVC2uaX7r[YQhcHWvYX6gUHhT[mW2YTDlfJBz\XO|ZXSgbY4hXEiSMTDj[YxteyCjc4Pld5Nm\CCjczDzeIlufWyjdHnvckBw\iClbz3hZ5RqfmG2b4KgdoVkenWrdH3lcpQh[nliRmLFWEBie3OjeTygSWM2OCB;IECuNFI4KM7:TT6= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ4NUi5O{c,OTd4NkW4PVc9N2F-
RAW264.7 MVLGeY5kfGmxbjDhd5NigQ>? NVzRUoxmOjRiaILz NYfsZoU{UW6mdXP0bY9vKG:oIGuzTH1kcG:uZYP0[ZJwdCCnZn\seZghcW5ibX;1d4UhWkGZMk[0Mlch[2WubIOgcI9i\GWmIIfpeIgh[WOndInsZZRm\C2ORFygZYZ1\XJiMkSgbJJ{NCCHQ{WwJF0hOC5yMkmg{txONg>? MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTdzN{OwOEc,OTl5MUezNFQ9N2F-
THP1 NVK0ZZdYTnWwY4Tpc44h[XO|YYm= MVrTeIlufWyjdHnvckBw\iCdM1jdZ4hwdGW|dHXyc4wh\W[obIX4JIlvKGi3bXHuJHRJWDFiZn;hcUBk\WyuczDsc4Fl\WRid3n0bEBi[y2ORFysJGVEPTBiPTCwMlA{OSEQvF2u M33PWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OUezNlg5Lz5zOEm3N|I5QDxxYU6=
CV1 NYXkUWt7TnWwY4Tpc44h[XO|YYm= NGfpPWxCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IFzYVoJmfGFibHnnZY5lKGKrbnTpcoch\G:vYXnuJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gWFE{OTdvaX7keYNm\CC2cnHud4NzcXC2aX;uZYwh[WO2aY\peJkhcW5iYX\ybYNidiCpcnXlckBud26tZYmgR3YyKGOnbHzzJINwNXS{YX7z[oVkfGWmIIfpeIghT2GuND3TVmMyKGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKgZZN{[XluIFnDOVAhRSByLkCzPVgyKM7:TT6= MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN2NUGwNkc,OjB|NEWxNFI9N2F-
THP1 M3niT2Z2dmO2aX;uJIF{e2G7 Mkj0RYdwdmm|dDDhZ5Rqfmm2eTDheEBISUxvbHnub4VlKGi3bXHuJGxZWmGucHjhJIV5eHKnc4Pl[EBqdiCWSGCxJINmdGy|IHHzd4V{e2WmIHHzJJN1cW23bHH0bY9vKG:oIHPvZYN1cX[jdH;yJJJm[3K3aYTt[Y51KGK7IF\SSXQh[XO|YYmsJGVEPTBiPTCwMlA6PyEQvF2u M2TXN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nk[1PFk4Lz5zN{[2OVg6PzxxYU6=
CV1 MVXGeY5kfGmxbjDhd5NigQ>? M3XBS2FvfGGpb37pd5Qh[WO2aY\peJkh[XRiTGjSZYxxcGFibHnnZY5lKGKrbnTpcoch\G:vYXnuJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gWFE{OTdvaX7keYNm\CC2cnHud4NzcXC2aX;uZYwh[WO2aY\peJkhcW5iYX\ybYNidiCpcnXlckBud26tZYmgR3YyKGOnbHzzJINwNXS{YX7z[oVkfGWmIIfpeIghT2GuND3TVmMyKGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKgZZN{[XluIFnDOVAhRSByLkGg{txONg>? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN2NUGwNkc,OjB|NEWxNFI9N2F-
SH-SY5Y MYHGeY5kfGmxbjDhd5NigQ>? NVv1RoZvOjRiaILz NGLkVYdC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJGxZWmKndHGg[ZhxemW|c3XkJIlvKGi3bXHuJHNJNVO\NWmgZ4VtdHNiY3:teJJidnOoZXP0[YQhf2m2aDDHZYw1NUyERDDh[pRmeiB{NDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyIE2gNE4yOyEQvF2u MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ4NES4NUc,OTl{NkS0PFE9N2F-
HepG2 MV3GeY5kfGmxbjDhd5NigQ>? NXvlVWZGTW[oZXP0JI9vKFOURVLQNYMh\2WwZTDlfJBz\XO|aX;uJIlvKGi3bXHuJGhmeEd{IHPlcIx{NCCHQ{WwJF0hOC5{MTFOwG0v MnrMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7N{OyPFgoRjF6OUezNlg5RC:jPh?=
HuH7 MoHkSpVv[3Srb36gZZN{[Xl? MmjvRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDy[YNwdWKrbnHueEBNYFKkZYThJIxq\2GwZDDibY5lcW6pIHTvcYFqdiCrbjDoeY1idiCKdVi3JINmdGy|IHPvMZRz[W6|ZnXjeIVlKHerdHig[pV{\WRiR3HsOE1FSkRiYomgeJJidnOjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwJF0hOC5|MTFOwG0v NV3JcnpnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5O|MzQDhpPkG4PVc{Ojh6PD;hQi=>
SH-SY5Y M1zJVGZ2dmO2aX;uJIF{e2G7 M3PwWVI1KGi{cx?= MVHB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIFzYVoFteGijIHX4dJJme3OnZDDpckBpfW2jbjDTTE1UYTW\IHPlcIx{KGOxLYTyZY5{\mWldHXkJJdqfGhiR3HsOE1NSkRiYX\0[ZIhOjRiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OCB;IECuN|Eh|ryPLh?= NY\obIpFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyOlQ1QDFpPkG5NlY1PDhzPD;hQi=>
CHO MY\GeY5kfGmxbjDhd5NigQ>? M361fWFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gUHhTKGKndHGgdoVk\XC2b4Kg[ZhxemW|c3XkJIlvKEOKTzDj[YxteyCkeTDy[ZBwenSncjDhd5NigSxiRVO1NEA:KDBwNEGg{txONg>? MoG5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyM{SxNVkoRjF5MEO0NVE6RC:jPh?=
CHOK1 MmfoSpVv[3Srb36gZZN{[Xl? M{DYPVI1KGi{cx?= NYjDSFN5SWexbnnzeEBi[3Srdnn0fUBifCCJYXy0MZRi\2enZDDMXHJj\XSjIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJGNJV0tzIHPlcIx{KGGodHXyJFI1KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVAhRSByLkSyJO69VS5? NVfzSYp2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2O|c3PjRpPkK1Olc4PjZ2PD;hQi=>
THP1 M1LncmZ2dmO2aX;uJIF{e2G7 Mn:xSYZn\WO2IH;uJGFDS0FzIHflcoUh\XiycnXzd4lwdiCrbjDoeY1idiCmaX\m[ZJmdnSrYYTl[EBVUFBzIHPlcIx{NCCHQ{WwJF0hOC52M{Sg{txONg>? Mn62QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7N{OyPFgoRjF6OUezNlg5RC:jPh?=
CV1 M{HkcWZ2dmO2aX;uJIF{e2G7 NX;nepo3SWexbnnzeEBi[3Srdnn0fUBifCCOWGLi[ZRiKGyrZ3Hu[EBjcW6maX7nJIRwdWGrbj3t[YRq[XSnZDD0doFve2O{aYD0bY9v[WxiYXP0bZZqfHliaX6gZYZzcWOjbjDndoVmdiCvb37r[ZkhS1ZzIHPlcIx{KGOxLYTyZY5{\mWldHXkJJdqfGhiR3HsOE1UWkNzIHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh[XO|YYmsJGVEPTBiPTCwMlUxOTF7IN88UU4> M1;LTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{S1NVAzLz5{MEO0OVExOjxxYU6=
HuH7 MVXGeY5kfGmxbjDhd5NigQ>? MVXB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIILlZ49u[mmwYX70JGxZWmGucHjhJIxq\2GwZDDibY5lcW6pIHTvcYFqdiCrbjDoeY1idiCKdVi3JINmdGy|IHPvMZRz[W6|ZnXjeIVlKHerdHig[pV{\WRiR3HsOE1FSkRiYomgeJJidnOjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwJF0hOC54NjFOwG0v Mk\BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7N{OyPFgoRjF6OUezNlg5RC:jPh?=
CV1 NEjvXlJHfW6ldHnvckBie3OjeR?= NHjFU|FC\2:waYP0JIFkfGm4aYT5JIF1KEy[UnHsdIhiKGyrZ3Hu[EBjcW6maX7nJIRwdWGrbj3t[YRq[XSnZDD0doFve2O{aYD0bY9v[WxiYXP0bZZqfHliaX6gZYZzcWOjbjDndoVmdiCvb37r[ZkhS1ZzIHPlcIx{KGOxLYTyZY5{\mWldHXkJJdqfGhiR3HsOE1UWkNzIHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh[XO|YYmsJGVEPTBiPTCwMlc6PDN|IN88UU4> MonGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NEWxNFIoRjJyM{S1NVAzRC:jPh?=
CHOK1 MVvGeY5kfGmxbjDhd5NigQ>? NGK5XW4zPCCqcoO= MoWwRYdwdmm|dDDhZ5Rqfmm2eTDheEBI[Wx2LYTh[4dm\CCOWGLhcJBp[SBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDDTG9MOSClZXzsd{Bi\nSncjCyOEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwJF0hOS5|IN88UU4> MmLhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4N{e2OlQoRjJ3Nke3OlY1RC:jPh?=
HepG2 MYrGeY5kfGmxbjDhd5NigQ>? M1zBSmVn\mWldDDvckB1emmpbInj[ZJq\GViYXPjeY12dGG2aX;uJIlvKGi3bXHuJGhmeEd{IHPlcIx{NCCHQ{WwJF0hOi5yMEKg{txONg>? NULzd3pYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5O|MzQDhpPkG4PVc{Ojh6PD;hQi=>
HepG2 MUfGeY5kfGmxbjDhd5NigQ>? MWm1NFAhdk1? NGDFRo1KdmirYnn0bY9vKG:oIEKtLFMuMDNvKDiyMYNpdG:{bz2zMUh1emmobIXvdo9u\XSqeXypZoVvgnmuKTiyMFIu\GmyaHXufYxmfGi7bDnhcYlvdymycn;wc5h6MXCqZX75cEli[2W2aXOgZYNq\C2rbnT1Z4VlKHO{ZXLwNYMhdVKQQTDlfJBz\XO|aX;uJIlvKGi3bXHuJGhmeEd{IHPlcIx{KGG2IEWwNEBvVQ>? MmfsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh6MEC3OlcoRjF6OECwO|Y4RC:jPh?=
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Assay
Methods Test Index PMID
Western blot Skp2 / pEGFR / EGFR / pERK / ERK LXRα / LXRβ / ABCA1 / ABCG1 25184494 11604492
Immunofluorescence LAMP-1 / LDLR pRelA 23382078 26635040
Growth inhibition assay Cell viability 25184494
体内研究 在小鼠体内,GW3965在10 mg/kg剂量下使ABCA1表达上调8倍,并使循环水平提高30%,Cmax为12.7 μg/mL ,t1/2为2小时。[1] 在LDLR−/−和apoE−/−小鼠体内,GW3965 (10mg/kg)诱导ABCA1 和ABCG1表达,并表现出有效的抗动脉粥样硬化活性。[2]在雄性sprague-dawley大鼠体内,GW3965降低Ang II介导的血压增加,并减少血管Ang II受体基因表达。[3]在恶性胶质瘤小鼠模型中,GW3965导致LDLR降解,增加ABCA1胆固醇外排转运体的表达,从而有效促进肿瘤细胞死亡。[5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

动物实验:[1]
  • Animal Models: C57BL/6 小鼠
  • Dosages: ≤10 mg/kg
  • Administration: 口服

溶解度(25°C)

体外

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 618.51
化学式

C33H31ClF3NO3.HCl

CAS号 405911-17-3
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

技术支持

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操作手册

如果有其他问题,请给我们留言。

* 必填项

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常见问题及建议解决方法

问题 1:
How to formulate the compound for mouse in vivo experiment?

回答:
S2630 GW3965 HCl can be dissolved in 2% DMSO/30% PEG 300/dd H2O at 10 mg/mL as a homogeneous suspension. This vehicle is suitable for oral gavage to mice.