NU7441 (KU-57788)

For research use only. Not for use in humans.

目录号：S2638

CAS No. 503468-95-9

NU7441 (KU-57788)是一种高度有效的，选择性DNA-PK抑制剂，在无细胞试验中IC50为14 nM，也会抑制 mTOR 和 PI3K，对应的IC50值分别为1.7 μM和5 μM。它可降低NHEJ的频率，而增强Cas9介导DNA剪接后发生的同源重组修复率。

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10mM (1mL in DMSO)	RMB 922.34	现货
5mg	RMB 565.91	现货
50mg	RMB 3040.41	现货
200mg	RMB 7928.18	现货
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客户使用Selleck生产的NU7441 (KU-57788)发表文献158篇：

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Br J Cancer, 2019, 121(7):600-610

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FASEB J, 2019, 33(1):1138-1150

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Mol Cell Biol, 2019, 39(24)e00181-19

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Retrovirology, 2019, 16(1):13

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Front Physiol, 2019, 10:616

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BMC Pulm Med, 2019, 19(1-:165

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Mol Biol Rep, 2019, 10.1007/s11033-019-04605-0

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Nucleic Acids Res, 2019, 47(21):10977-10993

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Nucleic Acids Res, 2019, 47(18):9467-9479

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Nucleic Acids Res, 2019, 47(16):8838-8859

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Cell Res, 2018, 28(7):756-770

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Nat Commun, 2018, 9(1):5351

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Cell Rep, 2018, 24(4):987-1000

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Int J Cancer, 2018,

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Cell Death Dis, 2018, 9(9):931

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FASEB J, 2018, 32(4):1818-1829

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Mol Cancer Ther, 2018, 17(12):2551-2563

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DNA Repair (Amst), 2018, 68:68-74

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Int J Mol Sci, 2018,

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Sci Rep, 2018, 8(1):9685

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Biochem Biophys Rep, 2018, 16:115-121

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Oncotarget, 2018, 9(9):8560-8572

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Nucleic Acids Res, 2017, 45(1):244-254

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Cancer Immunol Res, 2017, 5(9):790-803

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Cancer Res, 2017, 77(17):4567-4578

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EMBO Rep, 2017, 18(8):1412-1428

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Cell Death Discov, 2017, 3:17072

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Radiat Res, 2017, 188(6):597-604

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Blood, 2016, 128(4):574-83

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Nat Commun, 2016, 7:12880

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Cell Death Dis, 2016, 7(7):e2316

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PLoS One, 2016, 11(12):e0167454

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产品安全说明书

DNA-PK抑制剂选择性比较

生物活性

产品描述

靶点

DNA-PK ^[1] (Cell-free assay)	mTOR ^[1] (cell-free assay)	PI3K ^[1] (cell-free assay)
14 nM	1.7 μM	5 μM

体外研究

NU7441抑制DNA依赖性蛋白激酶 (DNA-PK) 比抑制其他PI3K相关激酶 (PIKK)家族成员选择性高，IC50 为14 nM。^[1] 电离辐射诱导或Etoposide诱导 DNA 损伤后，1 μM NU7441提高γH2AX病灶的持久性。NU7441 浓度为 0.5 μM 或 1 μM时，作用于SW620 和 LoVo细胞，显著提高电离辐射，Etoposide, 和 Doxorubicin 诱导的G2-M累积增多。^[2] NU7441浓度为1 μM时，引起 Doxorubicin和电离辐射诱导的DNA双链断裂的持久性，也稍微降低同源重组活性 DNA-PK充足的 M059-Fus-1和 DNA-PK缺陷的 M059 J人类肿瘤细胞。^[3] NU7441浓度为 10 μM 时，作用于缺乏和表达polη的细胞，抑制UV诱导 RPA p34过度磷酸化。^[4] NU7441 浓度为1 μM时，作用于慢性淋巴细胞性白血病细胞。提高Fludarabine诱导的γH2AX病灶水平，也相应地降低Fludarabine诱导的细胞死亡。^[5] NU7441浓度为 1 μM时，作用于慢性淋巴细胞性白血病细胞，抑制Mitoxantrone诱导的DNA-PKcs自磷酸化和修复。^[6]它可降低NHEJ的频率，而增强Cas9介导DNA剪接后发生的同源重组修复率 ^[7]。

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
NCI-H1770	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MnL0TWM2OD1yLkCyNVQ{KM7:TR?=	NXyxdpZtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
A172	NHzsb\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MoHSTWM2OD1yLkG1N\|E3KM7:TR?=	NXLsOnk2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
NCI-H526	NUDjZ5FRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NXvJTHhDUUN3ME2wMlI5PDB5IN88US=>	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
HDLM-2	NYjNSHFST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MYLJR\|UxRTBwM{KzOFUh\|ryP	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
HuO-3N1	MlvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MnLTTWM2OD1yLkS2OlM3KM7:TR?=	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
NCI-SNU-1	NFfm[m1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NV;hWJpFUUN3ME2wMlYxQTl2IN88US=>	M2TyfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
SK-N-AS	MmjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MUnJR\|UxRTBwNkKyNVYh\|ryP	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
LoVo	M{Pt[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NYnWdGQxUUN3ME2wMlg3PzR7IN88US=>	NYHaUlBFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
LAMA-84	NXLiUnJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M4jSWGlEPTB;MD65PFg{OyEQvF2=	NFO5Wmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
CTB-1	MkO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MkKxTWM2OD1zLkGxOVQ3KM7:TR?=	MkO4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
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NCI-H2347	Mn3HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MXnJR\|UxRTZwOUOyNVMh\|ryP	M{O1[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
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EPLC-272H	NHLDSIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MoO3TWM2OD15LkG2NlQ3KM7:TR?=	NVf3[Wk2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
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TI-73	NW\xUllpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MkX1TWM2OD1zNj65OFA5KM7:TR?=	M2rNXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
TK10	Mny5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NGTSeHNKSzVyPUG3MlAxPzlizszN	NF3mSJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
SW684	M2[wUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M3PLTGlEPTB;MUeuNFE2PCEQvF2=	NGDj[4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
RPMI-8866	Mmm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NFjudFBKSzVyPUG3MlA3QTlizszN	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
LNCaP-Clone-FGC	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MmrUTWM2OD1zNz61NlAyKM7:TR?=	NH7MOYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
NCI-H2291	NXSxe4Q2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MVXJR\|UxRTF6LkSzOFUh\|ryP	NV3BSIF2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
T47D	M2ntOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NFzMUI5KSzVyPUG4MlQ5QCEQvF2=	M4jM[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
A204	M4Hqfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MlPWTWM2OD1zOD61OFUzKM7:TR?=	NXTC[VRERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
HT-144	MoHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NUnTPZlYUUN3ME2xPE44PDJ5IN88US=>	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
MDA-MB-361	M{Pjc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NXi0TmFzUUN3ME2xPU4xPzF2IN88US=>	M4T2elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
HCC1806	NF3H[lRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M2m3cmlEPTB;MUmuNVU6OSEQvF2=	M3[4b\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
NCI-H596	MoTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M1u1bWlEPTB;MUmuOlM6OSEQvF2=	MmnqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
K-562	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NVLTNHZPUUN3ME2xPU45QTJ4IN88US=>	Ml7ZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
D-336MG	M3j1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MnLSTWM2OD1zOT65N\|IzKM7:TR?=	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
SK-MEL-2	NUL2VYozT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NYnpfYJVUUN3ME2yNE4yPTV7IN88US=>	MnTjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
HEC-1	MljVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MoTTTWM2OD1{MD60PVc5KM7:TR?=	M1rFelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
EW-13	M2rLbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			Mln1TWM2OD1{MD61OFQ{KM7:TR?=	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
Hs-578-T	M3r6Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NEPJdHZKSzVyPUKwMlU2QDNizszN	NXjqclVkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
SJSA-1	NWDQe2szT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NH\Zc3BKSzVyPUKwMlU3QDhizszN	NVjhNmpzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
RCC10RGB	Mmm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MV3JR\|UxRTJyLk[3NVkh\|ryP	NX3QdnlTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
LAN-6	Mn3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MY\JR\|UxRTJzLkCzPVYh\|ryP	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
NCI-H1048	NITWT4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M17rXWlEPTB;MkGuNlI2QCEQvF2=	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
CW-2	MnrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NYPPNWN{UUN3ME2yNU4zPzB3IN88US=>	M3zLOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
HCC2157	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M{\rRmlEPTB;MkGuN\|Yh\|ryP	NH7RUIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
EW-22	MnrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MV7JR\|UxRTJzLkO3OkDPxE1?	M{j5cFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
A253	MmDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MmXoTWM2OD1{MT60OFgyKM7:TR?=	MmrFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
BE-13	NEHCfGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NEmw[\|dKSzVyPUKxMlYyOTNizszN	NHL4Nm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
KINGS-1	NGnCOIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MlqwTWM2OD1{MT62N\|E3KM7:TR?=	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
ETK-1	NVjiVGdpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M36xUmlEPTB;MkGuPFE2OiEQvF2=	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
NCI-H2452	NIfrOmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MkGzTWM2OD1{MT64OlQ4KM7:TR?=	MlO0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
HPAF-II	M3K3Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MkX6TWM2OD1{MT64PVI{KM7:TR?=	NEG3dJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
D-542MG	NVTLcYM2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			Mn;5TWM2OD1{MT65NFY6KM7:TR?=	M{G3c\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
NCI-H630	M3fuPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NVG0T2ljUUN3ME2yNk4xOjl4IN88US=>	NV7hT3plRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
TGBC11TKB	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M4fGXGlEPTB;MkKuNFQ6KM7:TR?=	MkPDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
BCPAP	MmjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MXXJR\|UxRTJ{Lk[xNUDPxE1?	NH74TXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
HLE	M1PyR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NVHLV\|V5UUN3ME2yNk43QTdizszN	M{flOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
NCI-H727	MkLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NU[5VFQzUUN3ME2yNk44OzVizszN	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
RD	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NUfSNoFWUUN3ME2yNk44PTF6IN88US=>	MlHLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
NCI-H522	M2eyXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M17ydmlEPTB;MkKuPFQ{OSEQvF2=	M1fhWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
CGTH-W-1	NYS3UY5pT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NWH0[Y1SUUN3ME2yN{4xPjRzIN88US=>	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
SK-LU-1	M2DmR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MUfJR\|UxRTJ\|LkS2PFMh\|ryP	M1P0c\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
BB65-RCC	NV\pXVJLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MVjJR\|UxRTJ\|Lke4OlMh\|ryP	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
HSC-3	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NYj1ZWxKUUN3ME2yN{45PTJ5IN88US=>	M4DJSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
SK-MES-1	MnXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NEO5[IhKSzVyPUK0MlAyPjFizszN	MkS0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
DB	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M1\ydWlEPTB;MkSuNVAzQCEQvF2=	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
HO-1-N-1	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M2\ENWlEPTB;MkSuN\|A6OyEQvF2=	NXHkNo5qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
MKN1	MoHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MlrnTWM2OD1{ND62PEDPxE1?	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
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A673	MWfxTHRUKGG\|c3H5			MVTxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhSTZ5MzDj[Yxtew>?	M3LMT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
DAOY	MkfLdWhVWyCjc4PhfS=>			M{LUeJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCGQV;ZJINmdGy\|	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
Saos-2	M4\6OJFJXFNiYYPzZZk>			MU\xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW2Gxcz2yJINmdGy\|	NGDOWWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
BT-37	NYrm[WlleUiWUzDhd5NigQ>?			Mnm1dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKEKWLUO3JINmdGy\|	M1zrS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
RD	MorodWhVWyCjc4PhfS=>			NHntRmlyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiUlSgZ4VtdHN?	NV;YbplORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
BT-12	NXPWXnp2eUiWUzDhd5NigQ>?			M2jKVJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCEVD2xNkBk\Wyucx?=	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
MG 63 (6-TG R)	M3zIRpFJXFNiYYPzZZk>			MXTxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVUdiNkOgLFYuXEdiUjmgZ4VtdHN?	MmrDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
NB1643	NXTtcG1NeUiWUzDhd5NigQ>?			NEOwXnJyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTlKxOlQ{KGOnbHzz	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
OHS-50	MlrNdWhVWyCjc4PhfS=>			NWXJfmlTeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IF;IV{02OCClZXzsdy=>	NH22Rmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
SJ-GBM2	NFL2eGFyUFSVIHHzd4F6			M{jCXZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSj3HRm0zKGOnbHzz	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
SK-N-MC	MWjxTHRUKGG\|c3H5			MUHxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?=	NEnrXJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
NB-EBc1	NVy4XZZneUiWUzDhd5NigQ>?			M2fnV5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCQQj3FRoMyKGOnbHzz	Ml;EQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
LAN-5	MoGxdWhVWyCjc4PhfS=>			M2\pWZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCOQV6tOUBk\Wyucx?=	M3vUTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Rh18	NHHlVJNyUFSVIHHzd4F6			MlSydWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFKqMUigZ4VtdHN?	M4HqV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
INA-6	NYC2[HdPTnWwY4Tpc44h[XO\|YYm=	MlTrNVAhfU1?	MUG0JIhzew>?	NUTOZ\|c5UW6qaXLpeIlwdiCxZjDo[YF1KHOqb3PrJJJme3CxboPlJIlvKGi3bXHuJGlPSS14IHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBJW0ZvMTDt[YRq[XSnZDD1dJJm\3WuYYTpc44hd2ZidHjlJGhUWDd{IIDyc5RmcW5iZYjwdoV{e2mxbjDheEAyOCC3TTDwdoVqdmO3YnH0[YQh\m:{IESgbJJ{KG[xbHzve4VlKGK7IFjTVFkxKGmwaHnibZRweiCjbnSgTHNTKGmwZIXj[ZIhVl[SLVHVXVkzOiCjZHTpeIlwdiCvZXHzeZJm\CCjZoTldkA1KGi{	MkfFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2NUO5N\|EoRjJ6NEWzPVMyRC:jPh?=
INA-6	NFnzPFJHfW6ldHnvckBie3OjeR?=	M2PuW\|ExKHWP	NYTMfpdkPCCqcoO=	Mo\aTY5pcWKrdHnvckBw\iCqZXH0JJNpd2OtIILld5BwdnOnIHnuJIh2dWGwIFnORU03KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDIV2YuOSCvZXTpZZRm\CC3cILl[5Vt[XSrb36gc4YhfGinIFjTVFczKG2UTlGg[ZhxemW\|c3nvckBifCBzMDD1UUBxemWrbnP1ZoF1\WRiZn;yJFQhcHK\|IH\vcIxwf2WmIHL5JGhUWDlyIHnubIljcXSxcjDhcoQhUFOUIHnu[JVk\XJiTm\QMWFWYTl{MjDh[IRqfGmxbjDt[YF{fXKnZDDh[pRmeiB2IHjyd{Bj	NFnzT5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OES1N\|k{OSd-Mki0OVM6OzF:L3G+
INA-6	NIS0WndHfW6ldHnvckBie3OjeR?=	MlyzNVAhfU1?	NUHafmptPCCqcoO=	MYTEc5dvemWpdXzheIlwdiCxZjDOWnAuSVW\OUKyMYlv\HWlZXSgTHNHNTFicILveIVqdiCneIDy[ZN{cW:wIHnuJIh2dWGwIFnORU03KGOnbHzzJIF1KDFyIIXNJJBz\WmwY4XiZZRm\CCob4KgOEBpenNiZn;scI94\WRiYomgUnZRNUGXWUmyNkBi\GSrdHnvckBu\WG\|dYLl[EBi\nSncjC0JIhzeyCkeTDX[ZN1\XKwIHLsc5QhdWW2aH;k	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR3M{mzNUc,Ojh2NUO5N\|E9N2F-
INA-6	M3vFdGZ2dmO2aX;uJIF{e2G7	M13TdFExKHWP	MmnXOEBpenN?	MWjJcohq[mm2aX;uJI9nKE6YUD3BWXk6OjJvaX7keYNm\CCKU1[tNUBxcG:\|cHjvdplt[XSrb36gbY4hcHWvYX6gTW5CNTZiY3XscJMh[XRiMUCgeW0heHKnaX7jeYJifGWmIH\vdkA1KGi{czDmc4xtd3enZDDifUBPXlBvQWXZPVIzKGGmZHn0bY9vKG2nYYP1doVlKGGodHXyJFQhcHK\|IHL5JHdme3Sncn6gZoxwfCCvZYToc4Q>	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR3M{mzNUc,Ojh2NUO5N\|E9N2F-
INA-6	M4\TO2Z2dmO2aX;uJIF{e2G7	M2Po[lExKHWP	NXe3NIxqPCCqcoO=	NFHPbm1Fd3ewcnXneYxifGmxbjDv[kBPXlBvQWXZPVIzNWmwZIXj[YQhUFOILUGgcXJPSSCneIDy[ZN{cW:wIHnuJIh2dWGwIFnORU03KGOnbHzzJIF1KDFyIIXNJJBz\WmwY4XiZZRm\CCob4KgOEBpenNiZn;scI94\WRiYomgUnZRNUGXWUmyNkBi\GSrdHnvckBu\WG\|dYLl[EBi\nSncjC0JIhzeyCkeTDSWE1RS1JibXX0bI9l	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR3M{mzNUc,Ojh2NUO5N\|E9N2F-

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-DNA-PKcs / DNA-PKcs / p-ATM / ATM / p-ATR / ATR / Ku70 / p-CHK1 / p-CHK2/ p-AKT / RAD51; PubMed: 29344644 Oncol Rep SUNE1 cells were irradiated with 5 Gy in the presence or absence of NU7441 (2 µM). The expression of cell cycle checkpoint proteins and double strand break repair proteins was assayed by western blot analysis at 6 or 12 h post-IR. p-mTOR(Ser2448) / mTOR / p-S6K(Thr389); PubMed: 25714019 Oncotarget Phosphorylation of mTOR and p70S6K were detected by Western blot analysis 24 hours after treatment.	29344644 25714019

体内研究

NU7441按 10 mg/kg剂量腹腔注射处理携带SW620移植瘤的小鼠，按无毒剂量处理至少4小时，然后提高 Etoposide诱导的肿瘤生长延迟2倍。 ^[2]

细胞实验： ^[2]	- 合并 Cell lines: SW620, LoVo, V3-YAC和 V3细胞 Concentrations: 0.5 μM或 1 μM Incubation Time: 17 小时 Method: 通过克隆实验测定NU7441，Etoposide, Doxorubicin, 和电离辐射作用于SW620, LoVo, V3,和 V3-YAC细胞存活的效果。在有或无 NU7441(0.5 或 1.0 μM)存在时，使用Etoposide 或Doxorubicin处理6孔板或6-cm盘中指数生长的细胞16小时。放射增敏研究中， NU7441加到细胞中，1小时后，使用辐射处理。使用γ-射线 (3.1 Gy/min ¹³⁷Cesium)处理V3和V3-YAC 细胞。使用可用设备，使用X-射线 (2.9 Gy/min at 230 kV, 10 mA) 处理SW620 和 LoVo 细胞。辐射处理后，在有或无NU7441存在时，细胞再温育16小时。胰蛋白酶消化，收集细胞，计数，然后按每盘 100 到10⁵ 的密度接种在10-cm 直径的Petri盘中，盘中含无药物培养基，用于形成集落。使用结晶紫对集落进行染色，10 到 14天后，使用自动集落计数器计数。 (Only for Reference)
动物实验： ^[2]	- 合并 Animal Models: 携带 SW620移植瘤的雌性裸鼠 Dosages: 10 mg/kg Administration: 腹腔注射 (Only for Reference)

参考文献

- 合并

溶解度 (25°C)

体外	DMSO	4 mg/mL warmed (9.67 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O	0.5mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download NU7441 (KU-57788) SDF

分子量	413.49
化学式	C₂₅H₁₉NO₃S
CAS号	503468-95-9
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
Could you please suggest formulations of the drug for in vivo injection?
回答：
We tested the following formulation for in vivo use, 4% DMSO+30% PEG 300+5% Tween 80+ddH2O up to 1mg/mL. It is a clear solution.
问题 2：
Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?
回答：
Slight color variation due to different processing is normal and usually doesn't interfere with the function.

DNA-PK Signaling Pathway Map

DNA-PK Inhibitors with Unique Features

非特异性的DNA-PK抑制剂

PI-103 : DNA-PK, IC50=23 nM; p110α/β/δ/γ, IC50=2 nM/3 nM/3 nM/15 nM; mTOR, IC50=30 nM.
活性最高的DNA-PK抑制剂

PIK-75 : DNA-PK, IC50=2 nM.
最新的DNA-PK抑制剂

KU-0060648 : Dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 μM.
经典的DNA-PK抑制剂

NU7026 : Potent DNA-PK inhibitor with IC50 of 0.23 μM, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR.

研究领域

产品类型

定制您的化合物库

NU7441 (KU-57788)

客户使用Selleck生产的NU7441 (KU-57788)发表文献158篇：

产品安全说明书

DNA-PK抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download NU7441 (KU-57788) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

技术支持

常见问题及建议解决方法

DNA-PK Signaling Pathway Map

DNA-PK Inhibitors with Unique Features

相关DNA-PK产品