NU7441 (KU-57788)

For research use only. Not for use in humans.

目录号：S2638

CAS No. 503468-95-9

NU7441 (KU-57788)是一种高度有效的，选择性DNA-PK抑制剂，在无细胞试验中IC50为14 nM，也会抑制 mTOR 和 PI3K，对应的IC50值分别为1.7 μM和5 μM。它可降低NHEJ的频率，而增强Cas9介导DNA剪接后发生的同源重组修复率。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 922.34	现货
5mg	RMB 565.91	现货
50mg	RMB 3040.41	现货
200mg	RMB 7928.18	现货
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客户使用Selleck生产的NU7441 (KU-57788)发表文献174篇：

Immunity, 2021, S1074-7613(21)00069-8

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Cell Res, 2021, 10.1038/s41422-021-00528-3

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Nature, 2020, 10.1038/s41586-020-2960-y

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Nature, 2019, 74(7779):571-574

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Cancer Cell, 2019, 36(2):179-193

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Cell, 2019, 36(2):179-193

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Cancer Cell, 2018, 34(3):396-410

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Nat Biotechnol, 2017, 35(5):463-474

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Sci Transl Med, 2021, 13(600)eabc7275

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Sci Adv, 2021, 7(25)eabg6680

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J Clin Invest, 2021, 131(11)146256

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Nucleic Acids Res, 2021, gkab262

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Nucleic Acids Res, 2021, gkab743

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Cancers (Basel), 2021, 13(4)830

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Int J Biol Sci, 2021, 17(4):1026-1040

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Int J Mol Sci, 2021, 22(19)10512

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Mol Cancer Res, 2021, molcanres.0301.2021

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Acta Pharmacol Sin, 2021, 10.1038/s41401-020-00577-1

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Cell Signal, 2021, S0898-6568(21)00195-9

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Biochem Biophys Res Commun, 2021, 553:51-57

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Mol Biol Rep, 2021, 10.1007/s11033-020-06124-9

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FEBS Open Bio, 2021, 10.1002/2211-5463.13198

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Commun Biol, 2021, 4(1):484

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Sci Transl Med, 2021, 13(580)eabc4465

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Nucleic Acids Res, 2021, gkab051

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Blood, 2020, 5 pii: blood

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Adv Sci (Weinh), 2020, 7(20):2000157

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Mol Cell, 2020, S1097-2765(20)30723-1

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Nat Commun, 2020, 11(1):6182

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Nat Commun, 2020, 11(1):5775

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Nucleic Acids Res, 2020, 10.1093/nar/gkaa022

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Nucleic Acids Res, 2020, gkaa782

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Sci Immunol, 2020, 5(43)

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Clin Cancer Res, 2020, 10.1158/1078-0432.CCR-20-2269

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J Cell Biol, 2020, 219(11)e202001063

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Cell Rep, 2020, 32(8):108068

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Cell Rep, 2020, 32(11):108140

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Cell Rep, 2020, 33(2):108240

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Signal Transduct Target Ther, 2020, 4;5(1):20

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Mol Oncol, 2020, 26

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Mol Cancer Res, 2020, 10.1158/1541-7786.MCR-19-0507

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Front Oncol, 2020, 10:575711

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Int J Mol Sci, 2020, 21(17)E6383

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Int J Oncol, 2020, 57(4):939-955

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Int J Radiat Biol, 2020, 1-7

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J Cell Physiol, 2020, 10.1002/jcp.29927

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Nucleic Acids Res, 2020, 48(2):736-747

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University of Lübeck, 2020, N/A

PubMed: None ( click the link to review the publication )

Cancers (Basel), 2020, 12(9):E2356

PubMed: 32825402 ( click the link to review the publication )

Cancers (Basel), 2020, 12(6):1490

PubMed: 32517381 ( click the link to review the publication )

Oncotarget, 2020, 11(7):699-726

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NAR Cancer, 2020, 2(2):zcaa006

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Elife, 2020, 9:e57894

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J Biol Chem, 2020, 295(1):125-137

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Int J Mol Med, 2020, 45(6):1673-1684

PubMed: 32186748 ( click the link to review the publication )

Cell Rep, 2020, 32(6):108018

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Toxicol Lett, 2020, 318:104-113

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Biomed Pharmacother, 2020, 129:110427

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Nat Commun, 2019, 10(1):5304

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Nat Commun, 2019, 10(1):1577

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Nat Commun, 2019, 10(1):3925

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Nat Commun, 2019, 10(1):2866

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Clin Cancer Res, 2019, 25(18):5608-5622

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Genes Dev, 2019, 33(17-18):1175-1190

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Haematologica, 2019, 104(11):2225-2240

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J Cell Biol, 2019, 218(7):2113-2123

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Cell Rep, 2019, 29(11):3708-3725.e5

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Int J Cancer, 2019, 10.1002/ijc.32558

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Oncogene, 2019, 38(14):2451-2463

PubMed: 30532030 ( click the link to review the publication )
Cancers (Basel), 2019, 11(9)

PubMed: 31480356 ( click the link to review the publication )

Br J Cancer, 2019, 121(7):600-610

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FASEB J, 2019, 33(1):1138-1150

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FASEB J, 2019, 33(11):11668-11681

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FASEB J, 2019, 33(6):6778-6788

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PLoS Genet, 2019, 15(2):e1007925

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J Environ Manage, 2019, 244:77-82

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Mol Cancer Res, 2019, 17(12):2457-2468

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Toxicol Sci, 2019, 10.1093/toxsci/kfz178

PubMed: 31388677 ( click the link to review the publication )

Int J Mol Sci, 2019, 20(24)E6316

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J Biol Chem, 2019, 294(8):2827-2838

PubMed: 30598506 ( click the link to review the publication )

Mol Cell Biol, 2019, 39(24)e00181-19

PubMed: 31591143 ( click the link to review the publication )

J Pharmacol Exp Ther, 2019, 371(2):320-326

PubMed: 31455631 ( click the link to review the publication )

Retrovirology, 2019, 16(1):13

PubMed: 31036006 ( click the link to review the publication )

Front Physiol, 2019, 10:616

PubMed: 31178753 ( click the link to review the publication )

BMC Pulm Med, 2019, 19(1-:165

PubMed: 31464599 ( click the link to review the publication )

Mol Biol Rep, 2019, 10.1007/s11033-019-04605-0

PubMed: 31020489 ( click the link to review the publication )

Mol Biol Rep, 2019, 10.1007/s11033-019-05105-x

PubMed: 31583565 ( click the link to review the publication )

Mol Med Rep, 2019, 20(4):3609-3616

PubMed: 31485633 ( click the link to review the publication )

FEBS Open Bio, 2019, 9(7):1315-1326

PubMed: 31141305 ( click the link to review the publication )

Nucleic Acids Res, 2019, 47(21):10977-10993

PubMed: 31612207 ( click the link to review the publication )

Nucleic Acids Res, 2019, 47(18):9467-9479

PubMed: 31396623 ( click the link to review the publication )

Nucleic Acids Res, 2019, 47(16):8838-8859

PubMed: 31329944 ( click the link to review the publication )

Cell Res, 2018, 28(7):756-770

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Nat Commun, 2018, 9(1):5351

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Cell Rep, 2018, 24(4):987-1000

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Int J Cancer, 2018,

PubMed: 29363109 ( click the link to review the publication )

Cell Death Dis, 2018, 9(9):931

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FASEB J, 2018, 32(4):1818-1829

PubMed: 29162700 ( click the link to review the publication )

Mol Cancer Ther, 2018, 17(12):2551-2563

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Hum Mol Genet, 2018, 27(23):4024-4035

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Mol Cancer Res, 2018, 16(3):428-438

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Mol Cancer Res, 2018, 16(8):1241-1254

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DNA Repair (Amst), 2018, 68:68-74

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Mol Biol Cell, 2018, 29(15):1786-1797

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Int J Mol Sci, 2018,

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Sci Rep, 2018, 8(1):9685

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Nucleic Acids Res, 2018, 46(10):5050-5060

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Nucleic Acids Res, 2018, 46(17):8926-8939

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Sci Rep, 2018, 8(1):14421

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Biochem Biophys Rep, 2018, 16:115-121

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Oncotarget, 2018, 9(9):8560-8572

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JCI Insight, 2018, 3(3)98096

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Nucleic Acids Res, 2017, 45(1):244-254

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Cancer Immunol Res, 2017, 5(9):790-803

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Cancer Res, 2017, 77(17):4567-4578

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Cancer Res, 2017, 77(18):4745-4754

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J Cell Biol, 2017, 216(3):623-639

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EMBO Rep, 2017, 18(8):1412-1428

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Cell Death Discov, 2017, 3:17072

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J Biol Chem, 2017, 292(30):12424-12435

PubMed: 28592488 ( click the link to review the publication )

Mol Biol Cell, 2017, 28(26):3756-3772

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Int J Biochem Cell Biol, 2017, 92:164-172

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Radiat Res, 2017, 188(6):597-604

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PLoS One, 2017, 12(7):e0181608

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DNA Repair (Amst), 2017, 54:30-39

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Oncotarget, 2017, 8(52):90037-90049

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Oncotarget, 2017, 8(2):2916-2935

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Nat Cell Biol, 2016, 18(11):1196-1207

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blood, 2016, 10.1182/blood-2016-02-700328

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Blood, 2016, 128(4):574-83

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Nat Commun, 2016, 7:12880

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Oncogene, 2016, 35(5):577-586

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Cancer Lett, 2016, 383(1):41-52

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Cell Death Dis, 2016, 7(7):e2316

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Sci Rep, 2016, 6:22972

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Cell Cycle, 2016, 15(1):84-94

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PLoS One, 2016, 11(12):e0167454

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PLoS One, 2016, 11(5):e0155230

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PLoS One, 2016, 11(9):e0163049

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Nucleic Acids Res, 2016, 44(11):5204-17

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Oncotarget, 2016, 7(38):60807-60822

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Nucleic Acids Res, 2016, 44(8):3695-712

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Oncotarget, 2016, 7(40):65504-65513

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Mutat Res Genet Toxicol Environ Mutagen, 2016, 795:1-6

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Nat Cell Biol, 2015, 17(9):1158-68

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Leukemia, 2015, 29(5):1133-42

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Genome Med, 2015, 10.1186/s13073-015-0215-6

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Mol Cancer Ther, 2015, 14(8):1896-906

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Mol Cancer Res, 2015, 13(1):120-9

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Mol Cancer Res, 2015, 13(1):120-9

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Cancer Biol Ther, 2015, 16(11):1585-92

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Cell Cycle, 2015, 14(23):3713-24

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PLoS ONE, 2015,

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Anticancer Res, 2015, 35(7):3829-38

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Oncotarget, 2015, 6(16):14005-25

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Genes Dev, 2014, 28(8):875-87

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Cancer Res, 2014, 74(16):4282-94

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Oncogene, 2014, 10.1038/onc.2014.268

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ACS Chem Biol, 2014, 9(5):1160-71

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Toxicol Sci, 2014, 10.1093/toxsci/kfu207

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Biosci Rep, 2014, 34(3)

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Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2014,

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Uppsala University, 2014, Department of Radiology

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Mutat Res, 2014, 769:1-10

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Nucleic Acids Res, 2013, 41(22):10157-69

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Nucleic Acids Res, 2013, 41(7):4080-92

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Int J Radiat Oncol Biol Phys, 2013, 88(2):385-94

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产品安全说明书

DNA-PK抑制剂选择性比较

生物活性

产品描述

靶点

DNA-PK ^[1] (Cell-free assay)	mTOR ^[1] (cell-free assay)	PI3K ^[1] (cell-free assay)
14 nM	1.7 μM	5 μM

体外研究

NU7441抑制DNA依赖性蛋白激酶 (DNA-PK) 比抑制其他PI3K相关激酶 (PIKK)家族成员选择性高，IC50 为14 nM。^[1] 电离辐射诱导或Etoposide诱导 DNA 损伤后，1 μM NU7441提高γH2AX病灶的持久性。NU7441 浓度为 0.5 μM 或 1 μM时，作用于SW620 和 LoVo细胞，显著提高电离辐射，Etoposide, 和 Doxorubicin 诱导的G2-M累积增多。^[2] NU7441浓度为1 μM时，引起 Doxorubicin和电离辐射诱导的DNA双链断裂的持久性，也稍微降低同源重组活性 DNA-PK充足的 M059-Fus-1和 DNA-PK缺陷的 M059 J人类肿瘤细胞。^[3] NU7441浓度为 10 μM 时，作用于缺乏和表达polη的细胞，抑制UV诱导 RPA p34过度磷酸化。^[4] NU7441 浓度为1 μM时，作用于慢性淋巴细胞性白血病细胞。提高Fludarabine诱导的γH2AX病灶水平，也相应地降低Fludarabine诱导的细胞死亡。^[5] NU7441浓度为 1 μM时，作用于慢性淋巴细胞性白血病细胞，抑制Mitoxantrone诱导的DNA-PKcs自磷酸化和修复。^[6]它可降低NHEJ的频率，而增强Cas9介导DNA剪接后发生的同源重组修复率 ^[7]。

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
NCI-H1770	NWPCcWxPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MVjJR\|UxRTBwMEKxOFMh\|ryP	MnrSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
A172	M2r0e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M1XKcmlEPTB;MD6xOVMyPiEQvF2=	NWCyW\|ZKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
NCI-H526	NXrWfo1mT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MYPJR\|UxRTBwMki0NFch\|ryP	NVLxdWZ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
HDLM-2	Mlz2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MYDJR\|UxRTBwM{KzOFUh\|ryP	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
HuO-3N1	NFT3bY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NIT4RYpKSzVyPUCuOFY3OzZizszN	NFOyNJU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
NCI-SNU-1	NEfDR\|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M{H5O2lEPTB;MD62NFk6PCEQvF2=	MnHiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
SK-N-AS	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NW\NVVI1UUN3ME2wMlYzOjF4IN88US=>	MoXJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
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LAMA-84	Mn72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NIHh[Y1KSzVyPUCuPVg5OzNizszN	NFG0V4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
CTB-1	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NXOzbYh4UUN3ME2xMlEyPTR4IN88US=>	Ml7QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
KP-N-YS	M3T3eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MV3JR\|UxRTFwMUSyN\|Eh\|ryP	M3fySVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
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CHL-1	NEjH[5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NGOxSGNKSzVyPUGuNlE{PjhizszN	M17aUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
NB7	NF\4S4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M{ezd2lEPTB;MT6yOFc1PSEQvF2=	NVfhWFd[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
HL-60	NYW0VYVGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M4DSO2lEPTB;MT6zPFE6KM7:TR?=	MkjZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
639-V	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M{HDN2lEPTB;MT60OFEzQCEQvF2=	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
NCI-H1793	NX63WFBLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NETDd49KSzVyPUGuOFU5PCEQvF2=	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
NEC8	Mlq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MXTJR\|UxRTFwNUWzOUDPxE1?	NWL3VlNyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
PA-1	Mm\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NHfIfWtKSzVyPUGuOVgzQTRizszN	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
D-423MG	M1;JNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MljDTWM2OD1zLk[5N\|YyKM7:TR?=	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
NCI-H292	M3HHRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MkfKTWM2OD1zLke0NFE{KM7:TR?=	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
SK-MEL-1	MoHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NEHlbJpKSzVyPUGuO\|k1PzlizszN	NXjrTpVmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
LB2241-RCC	MoLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NIXTcGdKSzVyPUKuNVQyPDZizszN	NUG3Z3h6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
SK-MEL-3	NFzGXopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M2\FT2lEPTB;Mj6xOlQ6KM7:TR?=	M2W4UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
MHH-PREB-1	M4XyZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NUO2[m9XUUN3ME2yMlE3PjB7IN88US=>	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
BFTC-905	MmLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MXLJR\|UxRTJwMU[2PFch\|ryP	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
Ramos-2G6-4C10	NIG5T\|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MV\JR\|UxRTJwMUm5NFkh\|ryP	NFfJW5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
G-361	NVfxbI1CT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NGnuWJNKSzVyPUKuNlE3QCEQvF2=	NXSxZo9{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
MOLT-4	Mo\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			Mn3HTWM2OD1{LkKxPFg5KM7:TR?=	NWnoWmRnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
DEL	M3vZNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NGDES49KSzVyPUKuN\|U2PjRizszN	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
MV-4-11	MmSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NX;tbm1vUUN3ME2yMlM4OzlizszN	NUfhVW5PRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
SK-NEP-1	NVrlPXJFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M3jqUWlEPTB;Mj6zPFc5OyEQvF2=	M1O1XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
RS4-11	NG\td4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MofQTWM2OD1{LkW2NFI{KM7:TR?=	NGPRT4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
HuH-7	MnrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NFjlN3BKSzVyPUKuOVY4ODJizszN	MkXqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
A101D	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NEWzdGhKSzVyPUKuOlE{OzhizszN	NEHCVmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
KG-1	M3qz[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NXXyRW9VUUN3ME2yMlY4QTJ2IN88US=>	MnvUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
KALS-1	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MojTTWM2OD1{Lk[5OlM{KM7:TR?=	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
VMRC-RCZ	NHywNWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M2jUU2lEPTB;Mj63O\|MzQCEQvF2=	MnjpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
SK-UT-1	MnP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M1PUTGlEPTB;Mz6xOVMyKM7:TR?=	NGG2Tmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
SW962	M4fRe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			Mmf4TWM2OD1\|LkKwN\|UzKM7:TR?=	NXrJco5{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
DBTRG-05MG	NIjLdHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MVPJR\|UxRTNwMkiwPFUh\|ryP	NXvv[oR7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
PANC-08-13	Mm\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M3POS2lEPTB;Mz60NVI4QCEQvF2=	MmDZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
QIMR-WIL	NVW1Tm55T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M363RWlEPTB;Mz60NVM1OSEQvF2=	M2T6S\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
SK-MEL-30	NYjwWo1LT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M3XaNWlEPTB;Mz60NlU6QCEQvF2=	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
697	NXPzc4lYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MlX4TWM2OD1\|LkS0PVk{KM7:TR?=	NHnlcI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
NY	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MojGTWM2OD1\|LkS1NFIzKM7:TR?=	MknEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
ES7	NVXBOYxzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M2Tw[2lEPTB;Mz60OlczQSEQvF2=	Ml;RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
JVM-3	NEH2SItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NH\5RnJKSzVyPUOuOFgxPzdizszN	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
U031	MlPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NFHjPHZKSzVyPUOuOVk{PjhizszN	M3zsflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
BHT-101	NF3uc4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MXrJR\|UxRTNwNUm5PFUh\|ryP	MnPGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
8305C	NVriTXR4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NGDNNVRKSzVyPUOuOlE4OzZizszN	MoTMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
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CAL-54	Mo\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MmPvTWM2OD1zMT60PFEyKM7:TR?=	MmiyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
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BALL-1	NV7oUnNST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M3HVOmlEPTB;MUKuNlY3OiEQvF2=	NGf4fVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
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Becker	Ml\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NHLkVZhKSzVyPUGzMlA2QCEQvF2=	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
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NCI-H2030	M{PFWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M4mzUGlEPTB;MUOuNlA3OiEQvF2=	NUDDNYJWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
SNU-423	NVHqelZwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NESxSlRKSzVyPUGzMlM5OSEQvF2=	M3OwOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
CP50-MEL-B	Mo\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			Mom0TWM2OD1zMz62NlMzKM7:TR?=	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
NCI-H1092	MnnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MnLuTWM2OD1zMz63OFc2KM7:TR?=	M33vS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
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CAL-27	MmX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MoDSTWM2OD1zND6wO\|I4KM7:TR?=	M2TOclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
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BFTC-909	MlfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MlXMTWM2OD1zND61NFU2KM7:TR?=	NUT0SZQ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
D-566MG	M1jXb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NXvEWZp2UUN3ME2xOE44PzB4IN88US=>	NWjacWtzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
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MS-1	M{L5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NVTTNHZVUUN3ME2xOU42PjJ\|IN88US=>	NF7hfm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
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GB-1	M33nZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NWDG[ZZKUUN3ME2xOU43PDN5IN88US=>	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
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PANC-03-27	NWTC[HF7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NGDvZ5pKSzVyPUG2Mlc3PjJizszN	NIm4dYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
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HEC-1	NFjPOZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NW\qXVV3UUN3ME2yNE41QTd6IN88US=>	NIfmXFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
EW-13	M3H1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M176S2lEPTB;MkCuOVQ1OyEQvF2=	M2XFe\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
Hs-578-T	M3zWPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NFjyO\|BKSzVyPUKwMlU2QDNizszN	M1fFeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
SJSA-1	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MUTJR\|UxRTJyLkW2PFgh\|ryP	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
RCC10RGB	NWruRVJUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MVHJR\|UxRTJyLk[3NVkh\|ryP	NXn0W5FQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
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NCI-H1048	NHTMSVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NGXXfGVKSzVyPUKxMlIzPThizszN	M1fkZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
CW-2	MoTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NYLxPVhpUUN3ME2yNU4zPzB3IN88US=>	MmDBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
HCC2157	M3zlNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M{PBT2lEPTB;MkGuN\|Yh\|ryP	NYLMbGZIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
EW-22	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MYfJR\|UxRTJzLkO3OkDPxE1?	NFrLS5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
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BE-13	NIDKR4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MWnJR\|UxRTJzLk[xNVMh\|ryP	MkWyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
KINGS-1	MlezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NXW2SFRtUUN3ME2yNU43OzF4IN88US=>	M160dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
ETK-1	NUnmTHIyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M3\VVGlEPTB;MkGuPFE2OiEQvF2=	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
NCI-H2452	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M1nLeWlEPTB;MkGuPFY1PyEQvF2=	NHr2dHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
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BCPAP	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MnTNTWM2OD1{Mj62NVEh\|ryP	NWjP[nR6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
HLE	M{Pqd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NHXBfmVKSzVyPUKyMlY6PyEQvF2=	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
NCI-H727	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NUn0UFM2UUN3ME2yNk44OzVizszN	M{nFXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
RD	NF3OeHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MonsTWM2OD1{Mj63OVE5KM7:TR?=	M2fKbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
NCI-H522	MmjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MWrJR\|UxRTJ{Lki0N\|Eh\|ryP	M1\hbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
CGTH-W-1	M37EZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MlX3TWM2OD1{Mz6wOlQyKM7:TR?=	NVn3fotKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
SK-LU-1	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M4nYO2lEPTB;MkOuOFY5OyEQvF2=	MkjiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
BB65-RCC	M2TQS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NVjw[ZdHUUN3ME2yN{44QDZ\|IN88US=>	M1jXcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
HSC-3	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MYLJR\|UxRTJ\|Lki1Nlch\|ryP	M4n1O\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
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CHO	M{nad2Z2dmO2aX;uJIF{e2G7			NF\ofVFKdmirYnn0bY9vKG:oIHj1cYFvKEWURzDlfJBz\XO\|ZXSgbY4h[2m\|YYDybYRmKHS{ZXH0[YQhS0iRIHPlcIx{KGK7IFnvckBYd3KtczDhd5NigSxiSVO1NEA:KDF2IN88UU4>	M3O4elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OEW1PFM3Lz5{M{i1OVg{PjxxYU6=
A673	MV7xTHRUKGG\|c3H5			NVTiOVZNeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IFG2O\|Mh[2WubIO=	M2XNZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
DAOY	MVLxTHRUKGG\|c3H5			NF7Yb5JyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiRFHPXUBk\Wyucx?=	M37hV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
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BT-37	NIOxU49yUFSVIHHzd4F6			MoXodWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKEKWLUO3JINmdGy\|	NWXKbndyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
RD	M4X5NZFJXFNiYYPzZZk>			NVjINGJWeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGLEJINmdGy\|	M4fxNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
BT-12	MljudWhVWyCjc4PhfS=>			MlnsdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKEKWLUGyJINmdGy\|	M2XIXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
MG 63 (6-TG R)	M{\0OpFJXFNiYYPzZZk>			MoXjdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKE2JIE[zJEg3NVSJIGKpJINmdGy\|	MnTvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
NB1643	Mmq5dWhVWyCjc4PhfS=>			NEXwRXVyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTlKxOlQ{KGOnbHzz	M3Tt[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
OHS-50	MXLxTHRUKGG\|c3H5			NUTJeXF3eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IF;IV{02OCClZXzsdy=>	MlHCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
SJ-GBM2	NUXG[YNDeUiWUzDhd5NigQ>?			NEWwPI9yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1qtS2JOOiClZXzsdy=>	NF\Vbok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
SK-N-MC	NX[4N3oxeUiWUzDhd5NigQ>?			MUPxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?=	M3;4e\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
NB-EBc1	NUToN2JbeUiWUzDhd5NigQ>?			MlnwdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKE6ELVXCZ\|Eh[2WubIO=	NUm2NIJXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
LAN-5	MYPxTHRUKGG\|c3H5			NVrwUGFneUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IFzBUk02KGOnbHzz	M{DKS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Rh18	MVvxTHRUKGG\|c3H5			NXS2NXZMeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGLoNVgh[2WubIO=	NVfCTJN2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
INA-6	M{i5XGZ2dmO2aX;uJIF{e2G7	NW\Zfo9XOTBidV2=	NWT0SFZiPCCqcoO=	MmPDTY5pcWKrdHnvckBw\iCqZXH0JJNpd2OtIILld5BwdnOnIHnuJIh2dWGwIFnORU03KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDIV2YuOSCvZXTpZZRm\CC3cILl[5Vt[XSrb36gc4YhfGinIFjTVFczKHC{b4TlbY4h\XiycnXzd4lwdiCjdDCxNEB2VSCycnXpcoN2[mG2ZXSg[o9zKDRiaILzJIZwdGyxd3XkJIJ6KEiVUEmwJIlvcGmkaYTvdkBidmRiSGPSJIlv\HWlZYKgUnZRNUGXWUmyNkBi\GSrdHnvckBu\WG\|dYLl[EBi\nSncjC0JIhz	MmfiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2NUO5N\|EoRjJ6NEWzPVMyRC:jPh?=
INA-6	MYXGeY5kfGmxbjDhd5NigQ>?	NV\FeZNLOTBidV2=	MX:0JIhzew>?	MYjJcohq[mm2aX;uJI9nKGinYYSgd4hw[2ticnXzdI9ve2ViaX6gbJVu[W5iSV7BMVYh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIFjTSk0yKG2nZHnheIVlKHWycnXneYxifGmxbjDv[kB1cGViSGPQO\|IhdVKQQTDlfJBz\XO\|aX;uJIF1KDFyIIXNJJBz\WmwY4XiZZRm\CCob4KgOEBpenNiZn;scI94\WRiYomgTHNRQTBiaX7obYJqfG:{IHHu[EBJW1JiaX7keYNmeiCQVmCtRXV[QTJ{IHHk[Il1cW:wIH3lZZN2emWmIHHmeIVzKDRiaILzJII>	M2WzdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEWzPVMyLz5{OES1N\|k{OTxxYU6=
INA-6	MULGeY5kfGmxbjDhd5NigQ>?	MXuxNEB2VQ>?	MXq0JIhzew>?	NGK2ZZdFd3ewcnXneYxifGmxbjDv[kBPXlBvQWXZPVIzNWmwZIXj[YQhUFOILUGgdJJwfGWrbjDlfJBz\XO\|aX;uJIlvKGi3bXHuJGlPSS14IHPlcIx{KGG2IEGwJJVOKHC{ZXnuZ5Vj[XSnZDDmc5IhPCCqcoOg[o9tdG:5ZXSgZpkhVl[SLVHVXVkzOiCjZHTpeIlwdiCvZXHzeZJm\CCjZoTldkA1KGi{czDifUBY\XO2ZYLuJIJtd3RibXX0bI9l	NHq2Xpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OES1N\|k{OSd-Mki0OVM6OzF:L3G+
INA-6	NGLLTXFHfW6ldHnvckBie3OjeR?=	MYOxNEB2VQ>?	MlX2OEBpenN?	M1;Y[mlvcGmkaYTpc44hd2ZiTm\QMWFWYTl{Mj3pcoR2[2WmIFjTSk0yKHCqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBKVkFvNjDj[YxteyCjdDCxNEB2VSCycnXpcoN2[mG2ZXSg[o9zKDRiaILzJIZwdGyxd3XkJIJ6KE6YUD3BWXk6OjJiYXTkbZRqd25ibXXhd5Vz\WRiYX\0[ZIhPCCqcoOgZpkhX2W\|dHXyckBjdG:2IH3leIhw\A>?	NYLLTFd7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0OVM6OzFpPkK4OFU{QTNzPD;hQi=>
INA-6	M{H6d2Z2dmO2aX;uJIF{e2G7	NInEdmoyOCC3TR?=	M3m4WVQhcHK\|	MWLEc5dvemWpdXzheIlwdiCxZjDOWnAuSVW\OUKyMYlv\HWlZXSgTHNHNTFibWLORUBmgHC{ZYPzbY9vKGmwIHj1cYFvKEmQQT22JINmdGy\|IHH0JFExKHWPIIDy[Ylv[3WkYYTl[EBnd3JiNDDodpMh\m:ubH;3[YQh[nliTm\QMWFWYTl{MjDh[IRqfGmxbjDt[YF{fXKnZDDh[pRmeiB2IHjyd{BjgSCUVD3QR3IhdWW2aH;k	NVXGNJd4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0OVM6OzFpPkK4OFU{QTNzPD;hQi=>

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-DNA-PKcs / DNA-PKcs / p-ATM / ATM / p-ATR / ATR / Ku70 / p-CHK1 / p-CHK2/ p-AKT / RAD51; PubMed: 29344644 Oncol Rep SUNE1 cells were irradiated with 5 Gy in the presence or absence of NU7441 (2 µM). The expression of cell cycle checkpoint proteins and double strand break repair proteins was assayed by western blot analysis at 6 or 12 h post-IR. p-mTOR(Ser2448) / mTOR / p-S6K(Thr389); PubMed: 25714019 Oncotarget Phosphorylation of mTOR and p70S6K were detected by Western blot analysis 24 hours after treatment.	29344644 25714019

体内研究

NU7441按 10 mg/kg剂量腹腔注射处理携带SW620移植瘤的小鼠，按无毒剂量处理至少4小时，然后提高 Etoposide诱导的肿瘤生长延迟2倍。 ^[2]

细胞实验： ^[2]	- 合并 Cell lines: SW620, LoVo, V3-YAC和 V3细胞 Concentrations: 0.5 μM或 1 μM Incubation Time: 17 小时 Method: 通过克隆实验测定NU7441，Etoposide, Doxorubicin, 和电离辐射作用于SW620, LoVo, V3,和 V3-YAC细胞存活的效果。在有或无 NU7441(0.5 或 1.0 μM)存在时，使用Etoposide 或Doxorubicin处理6孔板或6-cm盘中指数生长的细胞16小时。放射增敏研究中， NU7441加到细胞中，1小时后，使用辐射处理。使用γ-射线 (3.1 Gy/min ¹³⁷Cesium)处理V3和V3-YAC 细胞。使用可用设备，使用X-射线 (2.9 Gy/min at 230 kV, 10 mA) 处理SW620 和 LoVo 细胞。辐射处理后，在有或无NU7441存在时，细胞再温育16小时。胰蛋白酶消化，收集细胞，计数，然后按每盘 100 到10⁵ 的密度接种在10-cm 直径的Petri盘中，盘中含无药物培养基，用于形成集落。使用结晶紫对集落进行染色，10 到 14天后，使用自动集落计数器计数。 (Only for Reference)
动物实验： ^[2]	- 合并 Animal Models: 携带 SW620移植瘤的雌性裸鼠 Dosages: 10 mg/kg Administration: 腹腔注射 (Only for Reference)

参考文献

- 合并

溶解度 (25°C)

体外	DMSO	4 mg/mL warmed (9.67 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O	0.5mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download NU7441 (KU-57788) SDF

分子量	413.49
化学式	C₂₅H₁₉NO₃S
CAS号	503468-95-9
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

技术支持

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操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
Could you please suggest formulations of the drug for in vivo injection?
回答：
We tested the following formulation for in vivo use, 4% DMSO+30% PEG 300+5% Tween 80+ddH2O up to 1mg/mL. It is a clear solution.
问题 2：
Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?
回答：
Slight color variation due to different processing is normal and usually doesn't interfere with the function.

DNA-PK Signaling Pathway Map

DNA-PK Inhibitors with Unique Features

非特异性的DNA-PK抑制剂

PI-103 : DNA-PK, IC50=23 nM; p110α/β/δ/γ, IC50=2 nM/3 nM/3 nM/15 nM; mTOR, IC50=30 nM.
活性最高的DNA-PK抑制剂

PIK-75 : DNA-PK, IC50=2 nM.
最新的DNA-PK抑制剂

KU-0060648 : Dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 μM.
经典的DNA-PK抑制剂

NU7026 : Potent DNA-PK inhibitor with IC50 of 0.23 μM, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR.

研究领域

产品类型

定制您的化合物库

NU7441 (KU-57788)

客户使用Selleck生产的NU7441 (KU-57788)发表文献174篇：

产品安全说明书

DNA-PK抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download NU7441 (KU-57788) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

技术支持

常见问题及建议解决方法

DNA-PK Signaling Pathway Map

DNA-PK Inhibitors with Unique Features

相关DNA-PK产品