NU7441 (KU-57788)

For research use only. Not for use in humans.

目录号：S2638

CAS No. 503468-95-9

NU7441 (KU-57788)是一种高度有效的，选择性DNA-PK抑制剂，在无细胞试验中IC50为14 nM，也会抑制 mTOR 和 PI3K，对应的IC50值分别为1.7 μM和5 μM。它可降低NHEJ的频率，而增强Cas9介导DNA剪接后发生的同源重组修复率。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 922.34	现货
5mg	RMB 565.91	现货
50mg	RMB 3040.41	现货
200mg	RMB 7928.18	现货
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客户使用Selleck生产的NU7441 (KU-57788)发表文献169篇：

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Nature, 2020, 10.1038/s41586-020-2960-y

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Nature, 2019, 74(7779):571-574

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Cancer Cell, 2019, 36(2):179-193

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Cell, 2019, 36(2):179-193

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Cancer Cell, 2018, 34(3):396-410

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Nat Biotechnol, 2017, 35(5):463-474

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Sci Transl Med, 2021, 13(600)eabc7275

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Sci Adv, 2021, 7(25)eabg6680

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J Clin Invest, 2021, 131(11)146256

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Nucleic Acids Res, 2021, gkab262

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Int J Biol Sci, 2021, 17(4): 1026-1040

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Acta Pharmacol Sin, 2021, 10.1038/s41401-020-00577-1

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Biochem Biophys Res Commun, 2021, 553:51-57

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Mol Biol Rep, 2021, 10.1007/s11033-020-06124-9

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FEBS Open Bio, 2021, 10.1002/2211-5463.13198

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Commun Biol, 2021, 4(1):484

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Sci Transl Med, 2021, 13(580)eabc4465

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Nucleic Acids Res, 2021, gkab051

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Blood, 2020, 5 pii: blood

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Adv Sci (Weinh), 2020, 7(20):2000157

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Mol Cell, 2020, S1097-2765(20)30723-1

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Nat Commun, 2020, 11(1):6182

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Sci Immunol, 2020, 5(43)

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Clin Cancer Res, 2020, 10.1158/1078-0432.CCR-20-2269

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Cell Rep, 2020, 33(2):108240

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Signal Transduct Target Ther, 2020, 4;5(1):20

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Mol Oncol, 2020, 26

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Mol Cancer Res, 2020, 10.1158/1541-7786.MCR-19-0507

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Front Oncol, 2020, 10:575711

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Int J Mol Sci, 2020, 21(17)E6383

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Int J Oncol, 2020, 57(4):939-955

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Int J Radiat Biol, 2020, 1-7

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J Cell Physiol, 2020, 10.1002/jcp.29927

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Nucleic Acids Res, 2020, 48(2):736-747

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Cancers (Basel), 2020, 12(9):E2356

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Cancers (Basel), 2020, 12(6):1490

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Oncotarget, 2020, 11(7):699-726

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NAR Cancer, 2020, 2(2):zcaa006

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Elife, 2020, 9:e57894

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J Biol Chem, 2020, 295(1):125-137

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Int J Mol Med, 2020, 45(6):1673-1684

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Cell Rep, 2020, 32(6):108018

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Toxicol Lett, 2020, 318:104-113

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Biomed Pharmacother, 2020, 129:110427

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Nat Commun, 2019, 10(1):5304

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Nat Commun, 2019, 10(1):1577

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Nat Commun, 2019, 10(1):3925

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Nat Commun, 2019, 10(1):2866

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Clin Cancer Res, 2019, 25(18):5608-5622

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Genes Dev, 2019, 33(17-18):1175-1190

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Haematologica, 2019, 104(11):2225-2240

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J Cell Biol, 2019, 218(7):2113-2123

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Cell Rep, 2019, 29(11):3708-3725.e5

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Int J Cancer, 2019, 10.1002/ijc.32558

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Oncogene, 2019, 38(14):2451-2463

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Cancers (Basel), 2019, 11(9)

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Br J Cancer, 2019, 121(7):600-610

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FASEB J, 2019, 33(1):1138-1150

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FASEB J, 2019, 33(11):11668-11681

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FASEB J, 2019, 33(6):6778-6788

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PLoS Genet, 2019, 15(2):e1007925

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J Environ Manage, 2019, 244:77-82

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Mol Cancer Res, 2019, 17(12):2457-2468

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Toxicol Sci, 2019, 10.1093/toxsci/kfz178

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Int J Mol Sci, 2019, 20(24)E6316

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J Biol Chem, 2019, 294(8):2827-2838

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Mol Cell Biol, 2019, 39(24)e00181-19

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J Pharmacol Exp Ther, 2019, 371(2):320-326

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Retrovirology, 2019, 16(1):13

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Front Physiol, 2019, 10:616

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BMC Pulm Med, 2019, 19(1-:165

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Mol Biol Rep, 2019, 10.1007/s11033-019-04605-0

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Mol Biol Rep, 2019, 10.1007/s11033-019-05105-x

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Mol Med Rep, 2019, 20(4):3609-3616

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FEBS Open Bio, 2019, 9(7):1315-1326

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Nucleic Acids Res, 2019, 47(21):10977-10993

PubMed: 31612207 ( click the link to review the publication )

Nucleic Acids Res, 2019, 47(18):9467-9479

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Nucleic Acids Res, 2019, 47(16):8838-8859

PubMed: 31329944 ( click the link to review the publication )

Cell Res, 2018, 28(7):756-770

PubMed: 29844578 ( click the link to review the publication )

Nat Commun, 2018, 9(1):5351

PubMed: 30559436 ( click the link to review the publication )

Cell Rep, 2018, 24(4):987-1000

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Int J Cancer, 2018,

PubMed: 29363109 ( click the link to review the publication )

Cell Death Dis, 2018, 9(9):931

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FASEB J, 2018, 32(4):1818-1829

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Mol Cancer Ther, 2018, 17(12):2551-2563

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Hum Mol Genet, 2018, 27(23):4024-4035

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Mol Cancer Res, 2018, 16(3):428-438

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Mol Cancer Res, 2018, 16(8):1241-1254

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DNA Repair (Amst), 2018, 68:68-74

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Mol Biol Cell, 2018, 29(15):1786-1797

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Int J Mol Sci, 2018,

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Sci Rep, 2018, 8(1):9685

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Nucleic Acids Res, 2018, 46(10):5050-5060

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Nucleic Acids Res, 2018, 46(17):8926-8939

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Sci Rep, 2018, 8(1):14421

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Biochem Biophys Rep, 2018, 16:115-121

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Oncotarget, 2018, 9(9):8560-8572

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JCI Insight, 2018, 3(3)98096

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Nucleic Acids Res, 2017, 45(1):244-254

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Cancer Immunol Res, 2017, 5(9):790-803

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Cancer Res, 2017, 77(17):4567-4578

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Cancer Res, 2017, 77(18):4745-4754

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J Cell Biol, 2017, 216(3):623-639

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EMBO Rep, 2017, 18(8):1412-1428

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Cell Death Discov, 2017, 3:17072

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J Biol Chem, 2017, 292(30):12424-12435

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Mol Biol Cell, 2017, 28(26):3756-3772

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Int J Biochem Cell Biol, 2017, 92:164-172

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Radiat Res, 2017, 188(6):597-604

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PLoS One, 2017, 12(7):e0181608

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DNA Repair (Amst), 2017, 54:30-39

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Oncotarget, 2017, 8(52):90037-90049

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Oncotarget, 2017, 8(2):2916-2935

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Nat Cell Biol, 2016, 18(11):1196-1207

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blood, 2016, 10.1182/blood-2016-02-700328

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Blood, 2016, 128(4):574-83

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Nat Commun, 2016, 7:12880

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Oncogene, 2016, 35(5):577-586

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Cancer Lett, 2016, 383(1):41-52

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Cell Death Dis, 2016, 7(7):e2316

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Sci Rep, 2016, 6:22972

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Cell Cycle, 2016, 15(1):84-94

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PLoS One, 2016, 11(12):e0167454

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PLoS One, 2016, 11(5):e0155230

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PLoS One, 2016, 11(9):e0163049

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Nucleic Acids Res, 2016, 44(11):5204-17

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Oncotarget, 2016, 7(38):60807-60822

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Oncotarget, 2016, 7(40):65504-65513

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Mutat Res Genet Toxicol Environ Mutagen, 2016, 795:1-6

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Nat Cell Biol, 2015, 17(9):1158-68

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Leukemia, 2015, 29(5):1133-42

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Genome Med, 2015, 10.1186/s13073-015-0215-6

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Mol Cancer Res, 2015, 13(1):120-9

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PLoS ONE, 2015,

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Oncotarget, 2015, 6(16):14005-25

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Cancer Res, 2014, 74(16):4282-94

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Oncogene, 2014, 10.1038/onc.2014.268

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Toxicol Sci, 2014, 10.1093/toxsci/kfu207

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Biosci Rep, 2014, 34(3)

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Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2014,

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Uppsala University, 2014, Department of Radiology

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Mutat Res, 2014, 769:1-10

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Nucleic Acids Res, 2013, 41(22):10157-69

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产品安全说明书

DNA-PK抑制剂选择性比较

生物活性

产品描述

靶点

DNA-PK ^[1] (Cell-free assay)	mTOR ^[1] (cell-free assay)	PI3K ^[1] (cell-free assay)
14 nM	1.7 μM	5 μM

体外研究

NU7441抑制DNA依赖性蛋白激酶 (DNA-PK) 比抑制其他PI3K相关激酶 (PIKK)家族成员选择性高，IC50 为14 nM。^[1] 电离辐射诱导或Etoposide诱导 DNA 损伤后，1 μM NU7441提高γH2AX病灶的持久性。NU7441 浓度为 0.5 μM 或 1 μM时，作用于SW620 和 LoVo细胞，显著提高电离辐射，Etoposide, 和 Doxorubicin 诱导的G2-M累积增多。^[2] NU7441浓度为1 μM时，引起 Doxorubicin和电离辐射诱导的DNA双链断裂的持久性，也稍微降低同源重组活性 DNA-PK充足的 M059-Fus-1和 DNA-PK缺陷的 M059 J人类肿瘤细胞。^[3] NU7441浓度为 10 μM 时，作用于缺乏和表达polη的细胞，抑制UV诱导 RPA p34过度磷酸化。^[4] NU7441 浓度为1 μM时，作用于慢性淋巴细胞性白血病细胞。提高Fludarabine诱导的γH2AX病灶水平，也相应地降低Fludarabine诱导的细胞死亡。^[5] NU7441浓度为 1 μM时，作用于慢性淋巴细胞性白血病细胞，抑制Mitoxantrone诱导的DNA-PKcs自磷酸化和修复。^[6]它可降低NHEJ的频率，而增强Cas9介导DNA剪接后发生的同源重组修复率 ^[7]。

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
NCI-H1770	MkfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NEPJS5VKSzVyPUCuNFIyPDNizszN	NV3KV5k6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
A172	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			Ml\WTWM2OD1yLkG1N\|E3KM7:TR?=	NXW2dFVGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
NCI-H526	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MYrJR\|UxRTBwMki0NFch\|ryP	M4\xdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
HDLM-2	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NE\scGpKSzVyPUCuN\|I{PDVizszN	NGTINWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
HuO-3N1	NVr0SZRCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M{Dae2lEPTB;MD60OlY{PiEQvF2=	MknvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
NCI-SNU-1	NU\YSoxyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NWnyZ\|BGUUN3ME2wMlYxQTl2IN88US=>	NUHOO\|lTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
SK-N-AS	MknNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NXXj[YFUUUN3ME2wMlYzOjF4IN88US=>	NWjpNoZ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
LoVo	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M2XsUmlEPTB;MD64Olc1QSEQvF2=	NFHyTYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
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NCI-H1563	NEjYWmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MYfJR\|UxRTFzLkGwNVEh\|ryP	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
CAL-54	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NHK1O\|BKSzVyPUGxMlQ5OTFizszN	NIDUU2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
WM-115	M1e5eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M3jFOmlEPTB;MUGuOlgzPCEQvF2=	NE\PWGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
COLO-684	MoXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MY\JR\|UxRTFzLkeyOlch\|ryP	NX;xe5kxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
HOP-62	NFXpWFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NUm3d\|lYUUN3ME2xNU44PTB6IN88US=>	M2\CRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
NCI-H650	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MkHyTWM2OD1zMT64PVYyKM7:TR?=	NUTMcnVyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
TE-11	M320XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MVLJR\|UxRTFzLkmzNVUh\|ryP	NILaU2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
COLO-679	NHH6cm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M4HXT2lEPTB;MUGuPVQ3KM7:TR?=	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
FTC-133	M1vJ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MlTpTWM2OD1zMj6wNFc3KM7:TR?=	NUDm[odTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
D-283MED	NHjlUXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NYDocYp2UUN3ME2xNk4xPTZ7IN88US=>	NEPoTIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
SK-PN-DW	NYHsUY97T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MULJR\|UxRTF{LkG5NFIh\|ryP	NIDDOVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
BALL-1	NYjqUXdpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NIO2[I5KSzVyPUGyMlI3PjJizszN	NVrpVVdMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
GT3TKB	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MnHJTWM2OD1zMj6zNFc1KM7:TR?=	NVTaWZJnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
HOP-92	NFj5WFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MYrJR\|UxRTF{LkWyN\|Mh\|ryP	NYnpU40{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
M14	M3j0cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M{XRNmlEPTB;MUOuNFM{PSEQvF2=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
SKG-IIIa	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NYDNem5KUUN3ME2xN{4xPTV2IN88US=>	M4\5PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
Becker	NVPPTIZiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MVXJR\|UxRTF\|LkC1PEDPxE1?	NXTibZZMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
ES5	NEHzWWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MWjJR\|UxRTF\|LkGzOVYh\|ryP	NVfvcFg6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
NCI-H2030	NVjKZmxnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MlPjTWM2OD1zMz6yNFYzKM7:TR?=	M1vNRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
SNU-423	NIi3XXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MVzJR\|UxRTF\|LkO4NUDPxE1?	M2\i[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
CP50-MEL-B	NGXLbHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MoDlTWM2OD1zMz62NlMzKM7:TR?=	MmDNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
NCI-H1092	NFfCRlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M{\GdmlEPTB;MUOuO\|Q4PSEQvF2=	NWPuR49[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
8-MG-BA	MoHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MlryTWM2OD1zMz63OVE{KM7:TR?=	M1HibFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
CAL-27	NHTDUnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MX\JR\|UxRTF2LkC3Nlch\|ryP	NHLuWFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
AGS	NGLZbo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M4XTOWlEPTB;MUSuNVMyQSEQvF2=	NXrJcWp[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
MZ2-MEL	MnT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MkjDTWM2OD1zND6xOFg5KM7:TR?=	M4e3R\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
BFTC-909	M1O3ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MVnJR\|UxRTF2LkWwOVUh\|ryP	NVvHWWtpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
D-566MG	NFXwUWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			Mn;iTWM2OD1zND63O\|A3KM7:TR?=	NFL0Z5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
MZ7-mel	NIHYPW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			Mor5TWM2OD1zNT6xNFY4KM7:TR?=	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFg3PzhxJ{7TRW5ITVJ:L3G+
TE-5	MkLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NGP3UVdKSzVyPUG1MlI{OzNizszN	MojIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
647-V	NGTSbYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M4TBS2lEPTB;MUWuNlcxPSEQvF2=	NEjH[HE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
DMS-114	NUHLVYtrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MmfLTWM2OD1zNT6zNlkyKM7:TR?=	NIPucnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
ME-180	MmP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M1G5e2lEPTB;MUWuOFc5OyEQvF2=	Mk\CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
MS-1	NUnOfGl3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NYS0dlNoUUN3ME2xOU42PjJ\|IN88US=>	M3vwUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
NUGC-3	NWnVeI1MT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MlXrTWM2OD1zNT62NlQ2KM7:TR?=	Mn\1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
GB-1	NIGy[INIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MYLJR\|UxRTF3Lk[0N\|ch\|ryP	NIDVS4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
LOXIMVI	NHLySpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MW\JR\|UxRTF3Lki5NVkh\|ryP	NXjw[4VJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
NCI-H1304	M4m4Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MnTiTWM2OD1zNT64PVI5KM7:TR?=	M121eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5QDZ5OD:nQnNCVkeHUkyvZV4>
KURAMOCHI	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MXvJR\|UxRTF3Lkm3NUDPxE1?	MmfxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
SW1783	M{fDNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M1f1bGlEPTB;MU[uNFk6OyEQvF2=	NIHWUZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDh4N{ivK\|5USU6JRWK8M4E,
EGI-1	M1XaWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NWDUS4RFUUN3ME2xOk42OzZ3IN88US=>	NWX3TYRVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
KGN	M33yRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NUjGRWtTUUN3ME2xOk42PTh4IN88US=>	MoLlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
PANC-03-27	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M1TRZmlEPTB;MU[uO\|Y3OiEQvF2=	NX;1NmhmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh6Nke4M{c,W0GQR1XSQE9iRg>?
RH-1	MmrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MmnkTWM2OD1zNj64NlUh\|ryP	Mn3jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg5Pjd6Lze+V2FPT0WUPD;hQi=>
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A673	MoG5dWhVWyCjc4PhfS=>			NULGcotYeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IFG2O\|Mh[2WubIO=	NV\Seox4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
DAOY	M3P2XpFJXFNiYYPzZZk>			NH:4[4FyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiRFHPXUBk\Wyucx?=	Mm\aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
Saos-2	MlnHdWhVWyCjc4PhfS=>			MYfxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW2Gxcz2yJINmdGy\|	NH;lTYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
BT-37	MVnxTHRUKGG\|c3H5			M{fCT5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCEVD2zO{Bk\Wyucx?=	MmT6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
RD	MYjxTHRUKGG\|c3H5			MoPRdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFKGIHPlcIx{	NYjIeZpiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
BT-12	NHfTfmpyUFSVIHHzd4F6			MWrxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhSlRvMUKgZ4VtdHN?	Ml7wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
MG 63 (6-TG R)	NGT4fJdyUFSVIHHzd4F6			M{PifZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCPRzC2N{ApPi2WRzDSLUBk\Wyucx?=	MlHqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
NB1643	MVTxTHRUKGG\|c3H5			NFvs[FByUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTlKxOlQ{KGOnbHzz	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
OHS-50	MUnxTHRUKGG\|c3H5			MVPxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhV0iVLUWwJINmdGy\|	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
SJ-GBM2	NHPlUY1yUFSVIHHzd4F6			NXnkeXI4eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGPKMWdDVTJiY3XscJM>	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
SK-N-MC	NEXnR4VyUFSVIHHzd4F6			Mkm1dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tUWMh[2WubIO=	M13LO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
NB-EBc1	Ml3udWhVWyCjc4PhfS=>			MXzxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVkJvRVLjNUBk\Wyucx?=	NVvZS2VORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
LAN-5	M{DGO5FJXFNiYYPzZZk>			M2[wZZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCOQV6tOUBk\Wyucx?=	MkTVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
Rh18	MoXsdWhVWyCjc4PhfS=>			M3HSdZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCUaEG4JINmdGy\|	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
INA-6	NWq0V3piTnWwY4Tpc44h[XO\|YYm=	NHnoPIEyOCC3TR?=	MWK0JIhzew>?	Ml;yTY5pcWKrdHnvckBw\iCqZXH0JJNpd2OtIILld5BwdnOnIHnuJIh2dWGwIFnORU03KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDIV2YuOSCvZXTpZZRm\CC3cILl[5Vt[XSrb36gc4YhfGinIFjTVFczKHC{b4TlbY4h\XiycnXzd4lwdiCjdDCxNEB2VSCycnXpcoN2[mG2ZXSg[o9zKDRiaILzJIZwdGyxd3XkJIJ6KEiVUEmwJIlvcGmkaYTvdkBidmRiSGPSJIlv\HWlZYKgUnZRNUGXWUmyNkBi\GSrdHnvckBu\WG\|dYLl[EBi\nSncjC0JIhz	NXnY[3lWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0OVM6OzFpPkK4OFU{QTNzPD;hQi=>
INA-6	MWHGeY5kfGmxbjDhd5NigQ>?	NFHaSXAyOCC3TR?=	M3XnfFQhcHK\|	NV[xZXFwUW6qaXLpeIlwdiCxZjDo[YF1KHOqb3PrJJJme3CxboPlJIlvKGi3bXHuJGlPSS14IHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBJW0ZvMTDt[YRq[XSnZDD1dJJm\3WuYYTpc44hd2ZidHjlJGhUWDd{IH3SUmEh\XiycnXzd4lwdiCjdDCxNEB2VSCycnXpcoN2[mG2ZXSg[o9zKDRiaILzJIZwdGyxd3XkJIJ6KEiVUEmwJIlvcGmkaYTvdkBidmRiSGPSJIlv\HWlZYKgUnZRNUGXWUmyNkBi\GSrdHnvckBu\WG\|dYLl[EBi\nSncjC0JIhzeyCk	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR3M{mzNUc,Ojh2NUO5N\|E9N2F-
INA-6	MYPGeY5kfGmxbjDhd5NigQ>?	NGPwdo4yOCC3TR?=	NETWO4o1KGi{cx?=	NF65V4JFd3ewcnXneYxifGmxbjDv[kBPXlBvQWXZPVIzNWmwZIXj[YQhUFOILUGgdJJwfGWrbjDlfJBz\XO\|aX;uJIlvKGi3bXHuJGlPSS14IHPlcIx{KGG2IEGwJJVOKHC{ZXnuZ5Vj[XSnZDDmc5IhPCCqcoOg[o9tdG:5ZXSgZpkhVl[SLVHVXVkzOiCjZHTpeIlwdiCvZXHzeZJm\CCjZoTldkA1KGi{czDifUBY\XO2ZYLuJIJtd3RibXX0bI9l	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR3M{mzNUc,Ojh2NUO5N\|E9N2F-
INA-6	M{LmNWZ2dmO2aX;uJIF{e2G7	MoTrNVAhfU1?	MXO0JIhzew>?	NVHpWHNzUW6qaXLpeIlwdiCxZjDOWnAuSVW\OUKyMYlv\HWlZXSgTHNHNTFicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKEmQQT22JINmdGy\|IHH0JFExKHWPIIDy[Ylv[3WkYYTl[EBnd3JiNDDodpMh\m:ubH;3[YQh[nliTm\QMWFWYTl{MjDh[IRqfGmxbjDt[YF{fXKnZDDh[pRmeiB2IHjyd{BjgSCZZYP0[ZJvKGKub4SgcYV1cG:m	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR3M{mzNUc,Ojh2NUO5N\|E9N2F-
INA-6	MnPUSpVv[3Srb36gZZN{[Xl?	Ml7hNVAhfU1?	NIDqdGk1KGi{cx?=	Mmf6SI94dnKnZ4XsZZRqd25ib3[gUnZRNUGXWUmyNk1qdmS3Y3XkJGhUTi1zIH3SUmEh\XiycnXzd4lwdiCrbjDoeY1idiCLTlGtOkBk\WyuczDheEAyOCC3TTDwdoVqdmO3YnH0[YQh\m:{IESgbJJ{KG[xbHzve4VlKGK7IF7WVE1CXVl7MkKgZYRlcXSrb36gcYVie3W{ZXSgZYZ1\XJiNDDodpMh[nliUmStVGNTKG2ndHjv[C=>	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR3M{mzNUc,Ojh2NUO5N\|E9N2F-

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-DNA-PKcs / DNA-PKcs / p-ATM / ATM / p-ATR / ATR / Ku70 / p-CHK1 / p-CHK2/ p-AKT / RAD51; PubMed: 29344644 Oncol Rep SUNE1 cells were irradiated with 5 Gy in the presence or absence of NU7441 (2 µM). The expression of cell cycle checkpoint proteins and double strand break repair proteins was assayed by western blot analysis at 6 or 12 h post-IR. p-mTOR(Ser2448) / mTOR / p-S6K(Thr389); PubMed: 25714019 Oncotarget Phosphorylation of mTOR and p70S6K were detected by Western blot analysis 24 hours after treatment.	29344644 25714019

体内研究

NU7441按 10 mg/kg剂量腹腔注射处理携带SW620移植瘤的小鼠，按无毒剂量处理至少4小时，然后提高 Etoposide诱导的肿瘤生长延迟2倍。 ^[2]

细胞实验： ^[2]	- 合并 Cell lines: SW620, LoVo, V3-YAC和 V3细胞 Concentrations: 0.5 μM或 1 μM Incubation Time: 17 小时 Method: 通过克隆实验测定NU7441，Etoposide, Doxorubicin, 和电离辐射作用于SW620, LoVo, V3,和 V3-YAC细胞存活的效果。在有或无 NU7441(0.5 或 1.0 μM)存在时，使用Etoposide 或Doxorubicin处理6孔板或6-cm盘中指数生长的细胞16小时。放射增敏研究中， NU7441加到细胞中，1小时后，使用辐射处理。使用γ-射线 (3.1 Gy/min ¹³⁷Cesium)处理V3和V3-YAC 细胞。使用可用设备，使用X-射线 (2.9 Gy/min at 230 kV, 10 mA) 处理SW620 和 LoVo 细胞。辐射处理后，在有或无NU7441存在时，细胞再温育16小时。胰蛋白酶消化，收集细胞，计数，然后按每盘 100 到10⁵ 的密度接种在10-cm 直径的Petri盘中，盘中含无药物培养基，用于形成集落。使用结晶紫对集落进行染色，10 到 14天后，使用自动集落计数器计数。 (Only for Reference)
动物实验： ^[2]	- 合并 Animal Models: 携带 SW620移植瘤的雌性裸鼠 Dosages: 10 mg/kg Administration: 腹腔注射 (Only for Reference)

参考文献

- 合并

溶解度 (25°C)

体外	DMSO	4 mg/mL warmed (9.67 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O	0.5mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download NU7441 (KU-57788) SDF

分子量	413.49
化学式	C₂₅H₁₉NO₃S
CAS号	503468-95-9
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
Could you please suggest formulations of the drug for in vivo injection?
回答：
We tested the following formulation for in vivo use, 4% DMSO+30% PEG 300+5% Tween 80+ddH2O up to 1mg/mL. It is a clear solution.
问题 2：
Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?
回答：
Slight color variation due to different processing is normal and usually doesn't interfere with the function.

DNA-PK Signaling Pathway Map

DNA-PK Inhibitors with Unique Features

非特异性的DNA-PK抑制剂

PI-103 : DNA-PK, IC50=23 nM; p110α/β/δ/γ, IC50=2 nM/3 nM/3 nM/15 nM; mTOR, IC50=30 nM.
活性最高的DNA-PK抑制剂

PIK-75 : DNA-PK, IC50=2 nM.
最新的DNA-PK抑制剂

KU-0060648 : Dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 μM.
经典的DNA-PK抑制剂

NU7026 : Potent DNA-PK inhibitor with IC50 of 0.23 μM, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR.

研究领域

产品类型

定制您的化合物库

NU7441 (KU-57788)

客户使用Selleck生产的NU7441 (KU-57788)发表文献169篇：

产品安全说明书

DNA-PK抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download NU7441 (KU-57788) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

技术支持

常见问题及建议解决方法

DNA-PK Signaling Pathway Map

DNA-PK Inhibitors with Unique Features

相关DNA-PK产品