NU7441 (KU-57788)

目录号：S2638

NU7441 (KU-57788) Chemical Structure

Molecular Weight(MW): 413.49

NU7441 (KU-57788)是一种高度有效的，选择性DNA-PK抑制剂，在无细胞试验中IC50为14 nM，也会抑制PI3K，IC50为5 μM。它可降低NHEJ的频率，而增强Cas9介导DNA剪接后发生的同源重组修复率。

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RMB 565.91 现货
RMB 974.57 现货
RMB 3040.41 现货
RMB 7928.18 现货
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客户使用Selleck该产品发表文献25篇：

客户使用该产品的6个实验数据：

  • Cells were treated with cisplatin under the following conditions: pretreatment with Nu7026 (Nu7026, 26) or Nu7441 (Nu7441, 41). Before DNA damage, wortmannin was applied at 100 nM for 30 min, Nu7026 at 10 uM for 1 h, Nu7441 at 1 uM for 1 h. Accompanying quantifications of the adjusted nucleolar EU fluorescence are shown. Each condition was normalized to cells treated with DMSO or indicated inhibitors without DNA damaging treatment. Two-way ANOVA was followed by Holm-Sidak's test for the comparison of cells with and without inhibitors. *, **, *** represent P ≤ 0.05, 0.01, 0.001, respectively.

    Nucleic Acids Res 2013 41(15), 7378-86. NU7441 (KU-57788) purchased from Selleck.

    Confocal immunostaining of S2056 phosphorylation of DNA-PKcs following radiation in HEK 293T and p18CycE-expressing cells.

    Nucleic Acids Res 2013 41, 10157-69. NU7441 (KU-57788) purchased from Selleck.

  • (C) Microirradiation live-cell microscopy of U2OS cells stably expressing mEGFP-MacroD2 full-length construct and treated with KU55933 10 μM, VE-821 1 μM, NU7441 1 μM or DMSO. Scale bar, 10 μm.

    Nucleic Acids Res, 2017, 45(1):244-254. NU7441 (KU-57788) purchased from Selleck.

    (C) Immunohistochemically detection of Cleaved Caspase-3 48 h after treatment to measure apoptosis in vivo, induced levels of apoptosis in xenografts treated with radiation in combination with DNA-PKcsi and HT compared to radiation alone. Necrotic areas were observed in xenograft of triple treatment. DNA-PKcsi：NU7441

    Oncotarget, 2016, 7(40): 65504-65513. NU7441 (KU-57788) purchased from Selleck.

  • Validation of activity and specificity of chemical inhibitors of; ATM, ATR, and DNAPK. H460 cells were treated with 1 uM camptothecin (CPT) or 20 ug/ml bleomycin for 1 h in the presence of the indicated inhibitors: DNAPK-i1—NU7026, DNAPK-i2—NU7441. MSH6, fibrillarin, and tubulin were used as loading controls.Effects of DNAPK inhibitors on its autophosphorylation in bleomycin-treated cells.

    Toxicol Sci 2014 10.1093/toxsci/kfu207. NU7441 (KU-57788) purchased from Selleck.

    After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of NU-7441 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. NU7441 (KU-57788) purchased from Selleck.

产品安全说明书

DNA-PK抑制剂选择性比较

生物活性

产品描述 NU7441 (KU-57788)是一种高度有效的，选择性DNA-PK抑制剂，在无细胞试验中IC50为14 nM，也会抑制PI3K，IC50为5 μM。它可降低NHEJ的频率，而增强Cas9介导DNA剪接后发生的同源重组修复率。
靶点
DNA-PK [1]
(Cell-free assay)
14 nM
体外研究

NU7441抑制DNA依赖性蛋白激酶 (DNA-PK) 比抑制其他PI3K相关激酶 (PIKK)家族成员选择性高，IC50 为14 nM。[1] 电离辐射诱导或Etoposide诱导 DNA 损伤后，1 μM NU7441提高γH2AX病灶的持久性。NU7441 浓度为 0.5 μM 或 1 μM时，作用于SW620 和 LoVo细胞，显著提高电离辐射，Etoposide, 和 Doxorubicin 诱导的G2-M累积增多。[2] NU7441浓度为1 μM时，引起 Doxorubicin和电离辐射诱导的DNA双链断裂的持久性，也稍微降低同源重组活性 DNA-PK充足的 M059-Fus-1和 DNA-PK缺陷的 M059 J人类肿瘤细胞。[3] NU7441浓度为 10 μM 时，作用于缺乏和表达polη的细胞，抑制UV诱导 RPA p34过度磷酸化。[4] NU7441 浓度为1 μM时，作用于慢性淋巴细胞性白血病细胞。提高Fludarabine诱导的γH2AX病灶水平，也相应地降低Fludarabine诱导的细胞死亡。[5] NU7441浓度为 1 μM时，作用于慢性淋巴细胞性白血病细胞，抑制Mitoxantrone诱导的DNA-PKcs自磷酸化和修复。[6]它可降低NHEJ的频率，而增强Cas9介导DNA剪接后发生的同源重组修复率 [7]。

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1770 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMEKxOFMh|ryP NY\iSJR7W0GQR1XS
A172 Mo\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMUWzNVYh|ryP MV7TRW5ITVJ?
NCI-H526 NHywcXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XBcGlEPTB;MD6yPFQxPyEQvF2= MoSyV2FPT0WU
HDLM-2 NGfyXIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLTTWM2OD1yLkOyN|Q2KM7:TR?= NVe1eWtkW0GQR1XS
HuO-3N1 NHjJOXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\pVIVKSzVyPUCuOFY3OzZizszN NYj4fpBQW0GQR1XS
NCI-SNU-1 M3nJ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHsOFlKSzVyPUCuOlA6QTRizszN MUTTRW5ITVJ?
SK-N-AS NYP6UHE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LIXGlEPTB;MD62NlIyPiEQvF2= NUf1OlNWW0GQR1XS
LoVo MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzITWM2OD1yLki2O|Q6KM7:TR?= M3jpV3NCVkeHUh?=
LAMA-84 M1zZN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIm2TIxKSzVyPUCuPVg5OzNizszN M3;IOXNCVkeHUh?=
CTB-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvBOYdKSzVyPUGuNVE2PDZizszN NUXuc3VtW0GQR1XS
KP-N-YS MoLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTFwMUSyN|Eh|ryP MnzRV2FPT0WU
HH MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjIPXpKSzVyPUGuNVgxQTNizszN NWnsZ|ZsW0GQR1XS
CHL-1 NHHtcGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{[zWGlEPTB;MT6yNVM3QCEQvF2= MlHKV2FPT0WU
NB7 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFj0fVZKSzVyPUGuNlQ4PDVizszN NEH3[|lUSU6JRWK=
HL-60 NWT6dFBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnnV5lKSzVyPUGuN|gyQSEQvF2= MWPTRW5ITVJ?
639-V NYn1XXN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjOTplKSzVyPUGuOFQyOjhizszN NIPafWtUSU6JRWK=
NCI-H1793 NGTzRWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXrSHVKSzVyPUGuOFU5PCEQvF2= MlLKV2FPT0WU
NEC8 NETEeWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnH2TWM2OD1zLkW1N|Uh|ryP NEfC[nRUSU6JRWK=
PA-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjCTWM2OD1zLkW4Nlk1KM7:TR?= NVPRN5l6W0GQR1XS
D-423MG NITwVI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHl[HNKSzVyPUGuOlk{PjFizszN MonTV2FPT0WU
NCI-H292 NXjISGhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fkfGlEPTB;MT63OFAyOyEQvF2= Mlf3V2FPT0WU
SK-MEL-1 NHPNPWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LseGlEPTB;MT63PVQ4QSEQvF2= NEftTIJUSU6JRWK=
LB2241-RCC MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[xZXcyUUN3ME2yMlE1OTR4IN88US=> MoTQV2FPT0WU
SK-MEL-3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTJwMU[0PUDPxE1? MVnTRW5ITVJ?
MHH-PREB-1 Mlz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TsbmlEPTB;Mj6xOlYxQSEQvF2= NY\ZU3VtW0GQR1XS
BFTC-905 M2K5[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvUZXhHUUN3ME2yMlE3Pjh5IN88US=> NUC4V3p2W0GQR1XS
Ramos-2G6-4C10 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTJwMUm5NFkh|ryP NXL0dnViW0GQR1XS
G-361 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnRTWM2OD1{LkKxOlgh|ryP MYTTRW5ITVJ?
MOLT-4 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoH1TWM2OD1{LkKxPFg5KM7:TR?= MULTRW5ITVJ?
DEL MoHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHycmluUUN3ME2yMlM2PTZ2IN88US=> NIfiVW5USU6JRWK=
MV-4-11 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTJwM{ezPUDPxE1? NHfzSINUSU6JRWK=
SK-NEP-1 MnvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTJwM{i3PFMh|ryP MkPPV2FPT0WU
RS4-11 M2m3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\SfGM4UUN3ME2yMlU3ODJ|IN88US=> MWLTRW5ITVJ?
HuH-7 NF3UcYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTJwNU[3NFIh|ryP Ml3DV2FPT0WU
A101D M4[4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLnTWM2OD1{Lk[xN|M5KM7:TR?= NUXuUYx4W0GQR1XS
KG-1 M1m5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NISye41KSzVyPUKuOlc6OjRizszN NUXFXZVuW0GQR1XS
KALS-1 NISxb3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTJwNkm2N|Mh|ryP MX7TRW5ITVJ?
VMRC-RCZ M1rrcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHlW4VEUUN3ME2yMlc4OzJ6IN88US=> MWrTRW5ITVJ?
SK-UT-1 NX3iNZppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjTZlFKSzVyPUOuNVU{OSEQvF2= M2ThdHNCVkeHUh?=
SW962 M4noNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTNwMkCzOVIh|ryP NGHuVWVUSU6JRWK=
DBTRG-05MG Mo\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWX0R4txUUN3ME2zMlI5ODh3IN88US=> MmnuV2FPT0WU
PANC-08-13 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPSTWM2OD1|LkSxNlc5KM7:TR?= M1zR[3NCVkeHUh?=
QIMR-WIL NVr0bVJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fVd2lEPTB;Mz60NVM1OSEQvF2= NGjVT|NUSU6JRWK=
SK-MEL-30 MonDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XxNWlEPTB;Mz60NlU6QCEQvF2= MUfTRW5ITVJ?
697 NIX4VYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTNwNES5PVMh|ryP M1nicHNCVkeHUh?=
NY NIfzbHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jlXWlEPTB;Mz60OVAzOiEQvF2= NYL5[VRtW0GQR1XS
ES7 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3y0d2lEPTB;Mz60OlczQSEQvF2= NGHlbFJUSU6JRWK=
JVM-3 MlmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHy0bJBKSzVyPUOuOFgxPzdizszN NHTwfZFUSU6JRWK=
U031 NU\MTXJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvITWM2OD1|LkW5N|Y5KM7:TR?= Ml;qV2FPT0WU
BHT-101 M4PRfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHpTWM2OD1|LkW5PVg2KM7:TR?= NWjkbnJOW0GQR1XS
8305C MnPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXSTWM2OD1|Lk[xO|M3KM7:TR?= NUjCW4xkW0GQR1XS
MG-63 MnfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHYWnlKSzVyPUOuOlI3PzZizszN Ml;UV2FPT0WU
NOS-1 NWTnbGZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1OzR2lEPTB;Mz62OVMyOiEQvF2= MlnsV2FPT0WU
YH-13 M1\nb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTNwOEexPFkh|ryP NF;Ub25USU6JRWK=
LXF-289 NULVZ2NTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTNwOUGwOFEh|ryP NHjPfJNUSU6JRWK=
GOTO M4DOTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\UT|FKSzVyPUOuPVE1QSEQvF2= NX3TU3RzW0GQR1XS
EKVX NHLafnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPWXIhwUUN3ME20MlIzPTJ2IN88US=> MULTRW5ITVJ?
CAL-51 NWLLcnczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1OwUGlEPTB;ND6yOFg2PCEQvF2= M37uTXNCVkeHUh?=
AN3-CA MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrMW4JKSzVyPUSuNlU5OTNizszN Mom3V2FPT0WU
IA-LM NXnBcYg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\xSZZKSzVyPUSuNlc6OzVizszN M2jGVnNCVkeHUh?=
KU-19-19 MnfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjvZWVKSzVyPUSuN|I6OjFizszN MXLTRW5ITVJ?
A704 NEOzSJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPuPFZGUUN3ME20MlQxQDh6IN88US=> NUfYN3NGW0GQR1XS
RH-18 NEXDbopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLSTWM2OD12LkS0PVU{KM7:TR?= NVPucXNKW0GQR1XS
IST-MEL1 NIOzVFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTRwNUiyOlMh|ryP MVPTRW5ITVJ?
LU-134-A NXm3bo5FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTWVZhKSzVyPUSuOVk3QDVizszN NXrTNpJQW0GQR1XS
SF126 NV;NWVhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4S3Z2lEPTB;ND62NFcyPSEQvF2= MoHtV2FPT0WU
EFO-27 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHzSHpKSzVyPUSuOlY2OjVizszN MXfTRW5ITVJ?
SN12C NVS3bJdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1P5WmlEPTB;ND63NVg6QCEQvF2= M4XCVnNCVkeHUh?=
L-363 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jkOGlEPTB;ND63O|EyPiEQvF2= NHq0[INUSU6JRWK=
MEL-HO NVTPd4NZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3G5[mlEPTB;ND63O|k5QSEQvF2= Mm\wV2FPT0WU
TYK-nu MmS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLwOm1KSzVyPUSuPFAyOjhizszN MVXTRW5ITVJ?
MDA-MB-415 NEPUNItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnKR|BIUUN3ME21MlAxOzF2IN88US=> MmXNV2FPT0WU
HCC70 NVz5fJp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTVwMEO5N|kh|ryP MonDV2FPT0WU
IGROV-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLmWnJqUUN3ME21MlI2Ojl{IN88US=> MmX6V2FPT0WU
NCI-H1355 NYjMNJFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDieZVKSzVyPUWuNlk3KM7:TR?= NWX3[3dkW0GQR1XS
23132-87 NVG0VGM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3voT2lEPTB;NT6zNlAzPCEQvF2= M2XUNnNCVkeHUh?=
NB69 M1HJN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTUTWM2OD13LkOyOFIh|ryP MVjTRW5ITVJ?
HSC-2 NGD4e4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXlWZdwUUN3ME21MlQyPzd|IN88US=> MnTIV2FPT0WU
KYSE-410 NHTFPYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HtUWlEPTB;NT60O|Y{PiEQvF2= NFr4SWhUSU6JRWK=
GCIY MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DCT2lEPTB;NT61NVM4QCEQvF2= MXjTRW5ITVJ?
A427 MoT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PRV2lEPTB;NT61N|Y3OSEQvF2= MXzTRW5ITVJ?
ChaGo-K-1 NIfQR29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTyenR3UUN3ME21MlU3PTl7IN88US=> NH7JN2pUSU6JRWK=
PFSK-1 Mmn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTVwNkKxPVQh|ryP MVjTRW5ITVJ?
MLMA NIjOenpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTUTHBIUUN3ME21Mlg{PjB4IN88US=> M1j5cXNCVkeHUh?=
RVH-421 M1e0fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkj2TWM2OD14LkC3N|M5KM7:TR?= M4XqTnNCVkeHUh?=
LB1047-RCC NGT6fVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTQXG9oUUN3ME22MlE4PTJ{IN88US=> NF\QN2FUSU6JRWK=
MHH-NB-11 NHn1NHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nGW2lEPTB;Nj6zNlczOSEQvF2= NV;xWGFiW0GQR1XS
J-RT3-T3-5 NGq0XpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\nZWVKSzVyPU[uOlMzQTFizszN MlO4V2FPT0WU
UM-UC-3 NVTDeYV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTZwNkSzN|Qh|ryP Mo\kV2FPT0WU
IST-SL1 NXr1T3hYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljwTWM2OD14Lk[5N|Y6KM7:TR?= M4nmOnNCVkeHUh?=
NB14 NGnoO|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzWfJhKSzVyPU[uO|k4PjFizszN MWnTRW5ITVJ?
NBsusSR MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYD4XIRCUUN3ME22MlgzPTB{IN88US=> MWPTRW5ITVJ?
D-263MG Mn7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWG0WFY2UUN3ME22MlkyODZ6IN88US=> MYDTRW5ITVJ?
NCI-H2347 NV7RR41UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInIcVdKSzVyPU[uPVMzOTNizszN NYrBcHhLW0GQR1XS
ES8 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jiU2lEPTB;Nj65O|U5QCEQvF2= NIXFVJZUSU6JRWK=
786-0 NX7ibIlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTdwMEm3PFYh|ryP NIr2XVdUSU6JRWK=
EPLC-272H MkXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjiTW0xUUN3ME23MlE3OjR4IN88US=> NFywbGtUSU6JRWK=
CAPAN-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1O5SWlEPTB;Nz6yOFM2QSEQvF2= NGL4dmVUSU6JRWK=
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SW982 M3;T[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmr4TWM2OD15LkOwNlA{KM7:TR?= M3Xpc3NCVkeHUh?=
OVCAR-4 M13UVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLHNnd5UUN3ME23MlMyOzJ6IN88US=> NVTGToV{W0GQR1XS
KARPAS-299 Mm\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnkSml{UUN3ME23MlMzPjJ{IN88US=> NIX1TGtUSU6JRWK=
MIA-PaCa-2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTdwM{[4NlMh|ryP MXzTRW5ITVJ?
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RO82-W-1 NH7NWnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zYTGlEPTB;Nz63OFU{OyEQvF2= MXHTRW5ITVJ?
NKM-1 MnXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfqR2lKSzVyPUeuO|Q6PTVizszN M3P5fXNCVkeHUh?=
CAL-12T Ml;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTdwOUSzOVIh|ryP MlzLV2FPT0WU
FADU NYLBTm81T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXvTWM2OD16LkCzOlU1KM7:TR?= NYnIUmZrW0GQR1XS
NCI-H28 MnHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nl[mlEPTB;OD6xOlk3OiEQvF2= NG\tW2ZUSU6JRWK=
LCLC-97TM1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHS2S|lKSzVyPUiuNlEyOjJizszN MojGV2FPT0WU
CHP-134 NUK5dHB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRThwMkSxPFUh|ryP M2LmZnNCVkeHUh?=
HT-1080 MoLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzzTWM2OD16LkK1NFk{KM7:TR?= NWDHNGc{W0GQR1XS
PC-3 M1OzTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzVV2RnUUN3ME24MlI4Ozl{IN88US=> NYXlVFU3W0GQR1XS
SNU-449 NXnVVVFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfwTWM2OD16LkK3PVMh|ryP NYroUpFWW0GQR1XS
VA-ES-BJ NWLNXGQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRThwM{S2PFYh|ryP NF\4V4xUSU6JRWK=
HT MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPjS4FiUUN3ME24MlM3PDlizszN MWTTRW5ITVJ?
HOS NIHaS2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Ll[WlEPTB;OD6zO|U5QSEQvF2= NF7kb3VUSU6JRWK=
KNS-62 M{XqR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NECxXYhKSzVyPUiuN|c4PjJizszN MYXTRW5ITVJ?
OAW-42 M3PVemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnT1TWM2OD16Lkm1PVY1KM7:TR?= M1\EO3NCVkeHUh?=
A549 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXywRXJNUUN3ME25MlA6PjF{IN88US=> NWf0W5ptW0GQR1XS
CAKI-1 MnTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zDWGlEPTB;OT6xOlYyKM7:TR?= NH73OmtUSU6JRWK=
HCC1937 M3XSW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTlwNkm4OlUh|ryP M1vUWHNCVkeHUh?=
GI-ME-N MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7oTWM2OD17LkewNVM4KM7:TR?= MWDTRW5ITVJ?
DU-4475 M2C2Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Lxb2lEPTB;OT65Olk{QSEQvF2= MXrTRW5ITVJ?
EM-2 NUTndHFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfqeWpYUUN3ME2xNE4zPDJ4IN88US=> NFjwbnFUSU6JRWK=
NCI-H1755 MoDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLXdYtKSzVyPUGwMlI1OjhizszN Mm\DV2FPT0WU
NCI-H1437 NYTmRmp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3aRYd3UUN3ME2xNE42PzJ3IN88US=> MXXTRW5ITVJ?
VM-CUB-1 NEWzUJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfvVmlUUUN3ME2xNE43OTZ2IN88US=> NXX4N44xW0GQR1XS
A2058 NEDSXHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkC2TWM2OD1zMD62OFA1KM7:TR?= NWDBTmFYW0GQR1XS
BPH-1 M3H3fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFH3ZYFKSzVyPUGwMlcyPDVizszN M3\MdHNCVkeHUh?=
NB5 NWnWbWJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DaRmlEPTB;MUCuO|U2QSEQvF2= NYfpbYhEW0GQR1XS
G-401 NG\0R4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37PXGlEPTB;MUCuO|YzPiEQvF2= MoHaV2FPT0WU
CAL-72 Ml3BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXf1SYwyUUN3ME2xNE45ODl2IN88US=> NXf5d4tkW0GQR1XS
SK-MEL-28 Mn\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTITWM2OD1zMD64NlAzKM7:TR?= MnLHV2FPT0WU
C32 NGXnUG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTFyLkizOFch|ryP MoXEV2FPT0WU
NCI-H1155 NITQTIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHPbGxKSzVyPUGwMlg{PzZizszN Mm\5V2FPT0WU
BB49-HNC M4mz[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHqXXNKSzVyPUGwMlg2QDZizszN MV;TRW5ITVJ?
GMS-10 NUGycVRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vTUWlEPTB;MUCuPFk4OSEQvF2= NH;rXYNUSU6JRWK=
K5 M3uwNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXDUYFKSzVyPUGwMlkxPzFizszN M{P3NnNCVkeHUh?=
OS-RC-2 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXXfHpKSzVyPUGxMlA2PTlizszN NHTM[VNUSU6JRWK=
HTC-C3 M122TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLsVWpKSzVyPUGxMlA4OTRizszN MmC1V2FPT0WU
LB996-RCC MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3KzO2lEPTB;MUGuNFczOyEQvF2= M{HYXXNCVkeHUh?=
NCI-H1563 NWHKZZI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTFzLkGwNVEh|ryP MUfTRW5ITVJ?
CAL-54 NH7FUJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDhT25KSzVyPUGxMlQ5OTFizszN MmLtV2FPT0WU
WM-115 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTFzLk[4NlQh|ryP MUXTRW5ITVJ?
COLO-684 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfSOHBEUUN3ME2xNU44OjZ5IN88US=> MUDTRW5ITVJ?
HOP-62 NUnPXWNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17YO2lEPTB;MUGuO|UxQCEQvF2= NUTzfJpuW0GQR1XS
NCI-H650 M1XRV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTFfYIyUUN3ME2xNU45QTZzIN88US=> NYPZdFBuW0GQR1XS
TE-11 NVLBSZpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTFzLkmzNVUh|ryP NH;hcpZUSU6JRWK=
COLO-679 NWT5T|dIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvoZppKSzVyPUGxMlk1PiEQvF2= NF7LR4NUSU6JRWK=
FTC-133 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXX2NGVFUUN3ME2xNk4xODd4IN88US=> NGfyRXVUSU6JRWK=
D-283MED MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTzXVNKSzVyPUGyMlA2PjlizszN NHzle3VUSU6JRWK=
SK-PN-DW M2fZNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUewfYNYUUN3ME2xNk4yQTB{IN88US=> MXXTRW5ITVJ?
BALL-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn33TWM2OD1zMj6yOlYzKM7:TR?= Mmf6V2FPT0WU
GT3TKB MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUT3PZZ4UUN3ME2xNk4{ODd2IN88US=> NF7oV4hUSU6JRWK=
HOP-92 NXT0TWplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnZS|lmUUN3ME2xNk42OjN|IN88US=> MXzTRW5ITVJ?
M14 M17Jbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzwfGJxUUN3ME2xN{4xOzN3IN88US=> NV7ySnNwW0GQR1XS
SKG-IIIa M1qxRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nFOWlEPTB;MUOuNFU2PCEQvF2= MmD4V2FPT0WU
Becker NX3KeXVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nWemlEPTB;MUOuNFU5KM7:TR?= M2L6VHNCVkeHUh?=
ES5 M{HqZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfZSoxKSzVyPUGzMlE{PTZizszN MoLBV2FPT0WU
NCI-H2030 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\pTWM2OD1zMz6yNFYzKM7:TR?= M4jWdXNCVkeHUh?=
SNU-423 MkK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTF|LkO4NUDPxE1? MXvTRW5ITVJ?
CP50-MEL-B MoDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTF|Lk[yN|Ih|ryP NHXMZXVUSU6JRWK=
NCI-H1092 NVfITZNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTuTWM2OD1zMz63OFc2KM7:TR?= MlfrV2FPT0WU
8-MG-BA NXLUPYt4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDxV29KSzVyPUGzMlc2OTNizszN MmXFV2FPT0WU
CAL-27 NF7zfXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXDdVJKSzVyPUG0MlA4OjdizszN MWDTRW5ITVJ?
AGS NVj4cVdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTF2LkGzNVkh|ryP M37VdnNCVkeHUh?=
MZ2-MEL NETZR|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvmS3ZKSzVyPUG0MlE1QDhizszN MofTV2FPT0WU
BFTC-909 Ml;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2W0c2lEPTB;MUSuOVA2PSEQvF2= NVXERXdqW0GQR1XS
D-566MG M{H6R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljwTWM2OD1zND63O|A3KM7:TR?= Mm\TV2FPT0WU
MZ7-mel NUXCcpdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;odmlEPTB;MUWuNVA3PyEQvF2= M1r6enNCVkeHUh?=
TE-5 NYPNZXRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDYeINKSzVyPUG1MlI{OzNizszN M{C2Z3NCVkeHUh?=
647-V MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTF3LkK3NFUh|ryP MkTCV2FPT0WU
DMS-114 MmPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33aPGlEPTB;MUWuN|I6OSEQvF2= MUnTRW5ITVJ?
ME-180 NYOzUpMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzSTWM2OD1zNT60O|g{KM7:TR?= NXnrdpljW0GQR1XS
MS-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPqe2ZKSzVyPUG1MlU3OjNizszN NIHneIZUSU6JRWK=
NUGC-3 NXX4bYJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGj3Z2ZKSzVyPUG1MlYzPDVizszN NXfv[Xg1W0GQR1XS
GB-1 NViwU45iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWi4ZVRJUUN3ME2xOU43PDN5IN88US=> MYrTRW5ITVJ?
LOXIMVI MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3OwTmlEPTB;MUWuPFkyQSEQvF2= NH75eFFUSU6JRWK=
NCI-H1304 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTF3Lki5Nlgh|ryP NUDCZm9EW0GQR1XS
KURAMOCHI Mm\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTF3Lkm3NUDPxE1? NGjCNYVUSU6JRWK=
SW1783 NWfYW2c3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTF4LkC5PVMh|ryP M3vIVnNCVkeHUh?=
EGI-1 MkG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTF4LkWzOlUh|ryP M{\oU3NCVkeHUh?=
KGN M{jCfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vKXmlEPTB;MU[uOVU5PiEQvF2= MnTBV2FPT0WU
PANC-03-27 Ml3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MliyTWM2OD1zNj63OlYzKM7:TR?= M17tS3NCVkeHUh?=
RH-1 NELsTHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLRPIpKSzVyPUG2MlgzPSEQvF2= NYLjWHNsW0GQR1XS
HT-1376 NVrKfld3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1GyNmlEPTB;MU[uPFQ1PiEQvF2= NFLycY1USU6JRWK=
ZR-75-30 NFTVVGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlH3TWM2OD1zNj65N|YyKM7:TR?= MXrTRW5ITVJ?
TI-73 NUTZUlN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX:2NZpxUUN3ME2xOk46PDB6IN88US=> MmHYV2FPT0WU
TK10 MoPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlP6TWM2OD1zNz6wNFc6KM7:TR?= MX3TRW5ITVJ?
SW684 Mlz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rFN2lEPTB;MUeuNFE2PCEQvF2= NVPoRY4yW0GQR1XS
RPMI-8866 NHXmUWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVr5cYhLUUN3ME2xO{4xPjl7IN88US=> NWnseWJ7W0GQR1XS
LNCaP-Clone-FGC M1\QWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYL0UVFlUUN3ME2xO{42OjBzIN88US=> MVjTRW5ITVJ?
NCI-H2291 M3PlSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIftZ3JKSzVyPUG4MlQ{PDVizszN NV7Xcot[W0GQR1XS
T47D NHPMVY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\USGNKSzVyPUG4MlQ5QCEQvF2= NEDkbXdUSU6JRWK=
A204 MkjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTF6LkW0OVIh|ryP MWPTRW5ITVJ?
HT-144 NFX0e3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTF6Lke0Nlch|ryP Ml7LV2FPT0WU
MDA-MB-361 NFjmSolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjpUJBKSzVyPUG5MlA4OTRizszN MkDYV2FPT0WU
HCC1806 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PxfmlEPTB;MUmuNVU6OSEQvF2= NXTH[|FMW0GQR1XS
NCI-H596 NFHtbnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFKxc2dKSzVyPUG5MlY{QTFizszN NWSy[VNwW0GQR1XS
K-562 MnXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjENJlKSzVyPUG5Mlg6OjZizszN NX\QdGt7W0GQR1XS
D-336MG NVG1SYp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWP0V5RzUUN3ME2xPU46OzJ{IN88US=> M320fXNCVkeHUh?=
SK-MEL-2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJyLkG1OVkh|ryP M4TEWnNCVkeHUh?=
HEC-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4ezUmlEPTB;MkCuOFk4QCEQvF2= M3K4THNCVkeHUh?=
EW-13 MoLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPNS5NFUUN3ME2yNE42PDR|IN88US=> M3PyTHNCVkeHUh?=
Hs-578-T Ml\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljlTWM2OD1{MD61OVg{KM7:TR?= NUHjUIR[W0GQR1XS
SJSA-1 NVflO|BjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rsemlEPTB;MkCuOVY5QCEQvF2= M1HqRXNCVkeHUh?=
RCC10RGB NFG3cGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3y2VGlEPTB;MkCuOlcyQSEQvF2= NHLMOY5USU6JRWK=
LAN-6 NXG3e4RrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTDTXRKUUN3ME2yNU4xOzl4IN88US=> MmnRV2FPT0WU
NCI-H1048 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTJzLkKyOVgh|ryP MnPUV2FPT0WU
CW-2 M2HESGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrw[5JKSzVyPUKxMlI4ODVizszN NF7Ed|ZUSU6JRWK=
HCC2157 NIH0b5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYixe5p1UUN3ME2yNU4{PiEQvF2= M1jpUHNCVkeHUh?=
EW-22 MlzJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3v6[GlEPTB;MkGuN|c3KM7:TR?= NEXwTWJUSU6JRWK=
A253 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTJzLkS0PFEh|ryP NIHONI5USU6JRWK=
BE-13 MmfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mme4TWM2OD1{MT62NVE{KM7:TR?= MWHTRW5ITVJ?
KINGS-1 NUPjRm1RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTJzLk[zNVYh|ryP Mn;UV2FPT0WU
ETK-1 NFPiWVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTaTWM2OD1{MT64NVUzKM7:TR?= MoDaV2FPT0WU
NCI-H2452 M4m3UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;FSmlEPTB;MkGuPFY1PyEQvF2= Ml7uV2FPT0WU
HPAF-II M{HYVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkn6TWM2OD1{MT64PVI{KM7:TR?= MU\TRW5ITVJ?
D-542MG Mk[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHL0NYdKSzVyPUKxMlkxPjlizszN MXzTRW5ITVJ?
NCI-H630 NIHsWmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml[wTWM2OD1{Mj6wNlk3KM7:TR?= MlHYV2FPT0WU
TGBC11TKB MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUew[oNGUUN3ME2yNk4xPDlizszN NFjGbVZUSU6JRWK=
BCPAP MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTJ{Lk[xNUDPxE1? M4r3OHNCVkeHUh?=
HLE NGOyeIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\3V2lEPTB;MkKuOlk4KM7:TR?= M{Xw[3NCVkeHUh?=
NCI-H727 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HwSGlEPTB;MkKuO|M2KM7:TR?= MkjNV2FPT0WU
RD M2XNVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkH0TWM2OD1{Mj63OVE5KM7:TR?= NGD0ZXlUSU6JRWK=
NCI-H522 NWT6UGRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjhW2pKSzVyPUKyMlg1OzFizszN M17RPHNCVkeHUh?=
CGTH-W-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\FPWlEPTB;MkOuNFY1OSEQvF2= MXnTRW5ITVJ?
SK-LU-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfTfFVLUUN3ME2yN{41Pjh|IN88US=> M3PEUHNCVkeHUh?=
BB65-RCC MoDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWO0XpBLUUN3ME2yN{44QDZ|IN88US=> MnzRV2FPT0WU
HSC-3 NEPwVnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTJ|Lki1Nlch|ryP NXzEXIFtW0GQR1XS
SK-MES-1 Mn6zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XmfGlEPTB;MkSuNFE3OSEQvF2= MoPmV2FPT0WU
DB MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIS4bllKSzVyPUK0MlExOjhizszN MUHTRW5ITVJ?
HO-1-N-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPxWJpKSzVyPUK0MlMxQTNizszN MXfTRW5ITVJ?
MKN1 M33ONmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLVTWM2OD1{ND62PEDPxE1? M4PVc3NCVkeHUh?=
MN-60 M4jsWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPSeotIUUN3ME2yOE45PTF7IN88US=> NG\nOoxUSU6JRWK=
8505C MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGq1[FVKSzVyPUK1MlE5PDVizszN MV;TRW5ITVJ?
COLO-320-HSR MofvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jC[WlEPTB;MkWuNlIxQCEQvF2= NUjyb2JnW0GQR1XS
BB30-HNC NYPMfYtnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYftPHhLUUN3ME2yOU4zPDh|IN88US=> MYjTRW5ITVJ?
KM12 NFPPV|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVO5XFRwUUN3ME2yOU42QDB5IN88US=> Mn7UV2FPT0WU
NB13 NX7McXNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2W0T2lEPTB;MkWuOVg6QCEQvF2= MUjTRW5ITVJ?
HCC2998 NWPydXRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHK0NYtKSzVyPUK2MlAzQDNizszN MYHTRW5ITVJ?
U-118-MG NX:5So9iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLDV256UUN3ME2yOk4xQDB6IN88US=> MnfBV2FPT0WU
NB10 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTJ4LkKzOEDPxE1? M1X3NXNCVkeHUh?=
SK-LMS-1 M{XEVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPaPWJKSzVyPUK3MlA4ODRizszN MorRV2FPT0WU
SW1573 NX[0[nVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTJ5LkGxJO69VQ>? NGnq[mJUSU6JRWK=
LB373-MEL-D M{ThbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1r5fWlEPTB;MkeuNVI6PCEQvF2= MYXTRW5ITVJ?
DK-MG NYDwbodUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmK0TWM2OD1{Nz6xPFE4KM7:TR?= M2f5S3NCVkeHUh?=
RMG-I Mo\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfMTWM2OD1{Nz6yNFI6KM7:TR?= MVrTRW5ITVJ?
SW1088 NGnYU2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTz[2VKSzVyPUK3MlUxPDJizszN Mmr3V2FPT0WU
SK-OV-3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTJ5Lke1PVMh|ryP Mnf6V2FPT0WU
KP-N-YN M3vxRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHLT3BKSzVyPUK3MlgxPDNizszN NHTtXXVUSU6JRWK=
RPMI-7951 NVu5coJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnoS3BKUUN3ME2yPE4zPDV4IN88US=> M2PY[3NCVkeHUh?=
CaR-1 M4LtVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\BfnJKSzVyPUK4MlU2QDJizszN NHjaRoNUSU6JRWK=
MKN7 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXWWndKSzVyPUK4MlU6PjRizszN NHiyUnRUSU6JRWK=
CHP-212 NGfqSZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTJ6Lke0NFEh|ryP NGHHNW9USU6JRWK=
KYSE-450 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJ6LkiwPVEh|ryP MYDTRW5ITVJ?
RXF393 MnLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TlZ2lEPTB;MkmuNlkxPiEQvF2= NE\sTVRUSU6JRWK=
P30-OHK NFPTOnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTJ7LkOwOFgh|ryP NYLOclJoW0GQR1XS
Ca9-22 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\tOYlKSzVyPUK5MlQzQTlizszN MnvHV2FPT0WU
RT-112 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrhZ5dKSzVyPUK5MlQ3OTFizszN NFPCToZUSU6JRWK=
ES1 MoHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1L3cGlEPTB;MkmuPFU1PCEQvF2= MmPyV2FPT0WU
HCE-4 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTJ7Lki3PFYh|ryP NFfJZplUSU6JRWK=
AM-38 NIPjS45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\mVGJKSzVyPUOwMlA3ODZizszN NHiydXpUSU6JRWK=
AsPC-1 NYS5bIlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTNyLkiwOVMh|ryP NYTrbWtmW0GQR1XS
TE-9 NF;qNY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHvZmRwUUN3ME2zNE45PzN5IN88US=> MV7TRW5ITVJ?
HuP-T4 NITib2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTNyLkm2N|gh|ryP MVzTRW5ITVJ?
LB2518-MEL Mme3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTNzLkC3OFQh|ryP NX3MbYJNW0GQR1XS
NCI-H1703 NUfifllIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHLTWM2OD1|MT6wPVA2KM7:TR?= MnPKV2FPT0WU
NCI-H2228 NWHXd2tVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFToO2pKSzVyPUOxMlQ3PTFizszN MUDTRW5ITVJ?
SCC-4 MmC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LXTmlEPTB;M{GuPVE5OSEQvF2= MWTTRW5ITVJ?
KNS-81-FD M4ruNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXexUFRkUUN3ME2zNk4xOTJ6IN88US=> Mkm1V2FPT0WU
NTERA-S-cl-D1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\iTWM2OD1|Mj6wO|M6KM7:TR?= MkL6V2FPT0WU
Daoy NV;4O3ZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{X2eWlEPTB;M{KuNFg{QCEQvF2= M3H5[HNCVkeHUh?=
ES4 M2judmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;Xb49uUUN3ME2zNk4{QTJ{IN88US=> Mn7KV2FPT0WU
MHH-ES-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTN{LkS4O|Ih|ryP MYPTRW5ITVJ?
C-33-A MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLlNVBiUUN3ME2zNk44PzJ6IN88US=> NXy3XlRIW0GQR1XS
BHY NGPkbJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPSVJg6UUN3ME2zNk46PDl3IN88US=> NHu1RZpUSU6JRWK=
Detroit562 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrSTHhKSzVyPUOzMlY3PTdizszN MmLiV2FPT0WU
EW-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPuTWM2OD1|Mz65N|IzKM7:TR?= MX;TRW5ITVJ?
NCI-H1395 M3L0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTN2LkC3PVkh|ryP NHO4NohUSU6JRWK=
KM-H2 M4\ldWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4P2e2lEPTB;M{[uOFc1OyEQvF2= MkTkV2FPT0WU
NCI-H520 M2LnUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nrdGlEPTB;M{[uO|U1OSEQvF2= MWDTRW5ITVJ?
D-392MG MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XvNmlEPTB;M{euN|M1PCEQvF2= Mn;FV2FPT0WU
NOMO-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHOTWM2OD1|Nz64NFg6KM7:TR?= NYTIVndTW0GQR1XS
TE-6 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTN6LkGyOEDPxE1? MXHTRW5ITVJ?
HT-3 NHi0fo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7UWoFKSzVyPUO4MlQ1OzZizszN NVLkZ|JvW0GQR1XS
RPMI-8226 NFPXbJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr6WHpKSzVyPUO4Mlk2OTlizszN MkX1V2FPT0WU
U251 NFLvVI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\1VGlEPTB;M{muNFEzPCEQvF2= M4rodnNCVkeHUh?=
GCT NHHI[3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;sVG9HUUN3ME2zPU4yQDV{IN88US=> MmrEV2FPT0WU
A431 MkLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHToRlBKSzVyPUO5MlE5QTRizszN M1PSV3NCVkeHUh?=
TE-12 Ml;SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{n3XmlEPTB;M{muNlQ1QCEQvF2= MmPhV2FPT0WU
HMV-II Mnf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLMXZlXUUN3ME2zPU42ODR5IN88US=> M17WUnNCVkeHUh?=
IST-MES1 NGi4VnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;ReHhKSzVyPUSwMlE2ODJizszN MYPTRW5ITVJ?
SW13 MoXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTRyLkWxPUDPxE1? MWPTRW5ITVJ?
SF295 NFvOcmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoH0TWM2OD12MD64NFY3KM7:TR?= MWjTRW5ITVJ?
MDA-MB-157 M1\JfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTRyLkm0OlIh|ryP M{G2T3NCVkeHUh?=
TE-1 M361cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTRzLki3NVQh|ryP Mli3V2FPT0WU
HuCCT1 MofzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\oTWM2OD12Mj61Nlg6KM7:TR?= NHPLfIpUSU6JRWK=
KYSE-510 NHG2V29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkT6TWM2OD12Mz6xO|U1KM7:TR?= NW[wb49TW0GQR1XS
NCI-H358 NHO3emdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLjTWM2OD12ND6wN|A1KM7:TR?= NGD6PGZUSU6JRWK=
SW900 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPCNZE2UUN3ME20OE4xPzV6IN88US=> NV7pZVJZW0GQR1XS
CAS-1 NVr3R2NNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\NW41KSzVyPUS0MlA6QTFizszN NWHZWJpYW0GQR1XS
TE-8 NVzIVmd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1uzbWlEPTB;NESuOVY2QCEQvF2= NHLvNIpUSU6JRWK=
P12-ICHIKAWA NX3sZlBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEj5cZBKSzVyPUS0MlYyOTJizszN NHfYVIdUSU6JRWK=
YKG-1 NILY[mFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLXTndKSzVyPUS0Mlc5OSEQvF2= NVG0cFU2W0GQR1XS
SNU-C2B MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\MSYhwUUN3ME20OE44QTB|IN88US=> MXnTRW5ITVJ?
LCLC-103H MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTR2Lki3NFMh|ryP NFj3VZVUSU6JRWK=
U-87-MG NE\vfZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmK3TWM2OD12NT6xNFIzKM7:TR?= M1Hye3NCVkeHUh?=
HAL-01 NEiyblJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS4[pppUUN3ME20OU4yOzd7IN88US=> NW[yTm95W0GQR1XS
OVCAR-8 MlT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\FTWM2OD12NT6zOVY1KM7:TR?= NGfYZZBUSU6JRWK=
KYSE-150 NEDOfIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrRZ|BKSzVyPUS3MlExPTJizszN NXn0S45CW0GQR1XS
OE33 M1nhcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4i4ZmlEPTB;NEeuNVQzQSEQvF2= M1m3OnNCVkeHUh?=
CAL-62 M3L0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rycWlEPTB;NEeuOFA3QCEQvF2= M2jHZXNCVkeHUh?=
TCCSUP NH\lbJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTR5Lk[yOlQh|ryP NYi3cIVbW0GQR1XS
H4 NEnCVZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLxW|JjUUN3ME20O{43PjJzIN88US=> NWq3d291W0GQR1XS
CP66-MEL MnjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTR6LkC3NFQh|ryP NGmz[WpUSU6JRWK=
SNB75 NHvqZ|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLsdJVjUUN3ME20PE4yQDd2IN88US=> M3rnbHNCVkeHUh?=
Mo-T MlfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TXTmlEPTB;NEiuNlc6KM7:TR?= NUDVW3lLW0GQR1XS
BT-549 NWjLWnMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXlTWM2OD12OD6zO|I6KM7:TR?= M4[2SHNCVkeHUh?=
IGR-1 NG\ybI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnz4TWM2OD12OD62OlQ2KM7:TR?= M1TzdXNCVkeHUh?=
NCI-H1299 NGnQOlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHUTWM2OD12OD63NlQ5KM7:TR?= MkjlV2FPT0WU
ALL-PO NYPsUGlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPLTWM2OD12OT65NlY5KM7:TR?= NU\VPGRHW0GQR1XS

... Click to View More Cell Line Experimental Data
体内研究 NU7441按 10 mg/kg剂量腹腔注射处理携带SW620移植瘤的小鼠，按无毒剂量处理至少4小时，然后提高 Etoposide诱导的肿瘤生长延迟2倍。 [2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验：

[2]
+ 展开
  • Cell lines: SW620, LoVo, V3-YAC和 V3细胞
  • Concentrations: 0.5 μM或 1 μM
  • Incubation Time: 17 小时
  • Method:

    通过克隆实验测定NU7441，Etoposide, Doxorubicin, 和电离辐射作用于SW620, LoVo, V3,和 V3-YAC细胞存活的效果。在有或无 NU7441(0.5 或 1.0 μM)存在时，使用Etoposide 或Doxorubicin处理6孔板或6-cm盘中指数生长的细胞16小时。放射增敏研究中， NU7441加到细胞中，1小时后，使用辐射处理。使用γ-射线 (3.1 Gy/min 137Cesium)处理V3和V3-YAC 细胞。使用可用设备，使用X-射线 (2.9 Gy/min at 230 kV, 10 mA) 处理SW620 和 LoVo 细胞。辐射处理后，在有或无NU7441存在时，细胞再温育16小时。胰蛋白酶消化，收集细胞，计数，然后按每盘 100 到105 的密度接种在10-cm 直径的Petri盘中， 盘中含无药物培养基，用于形成集落。使用结晶紫对集落进行染色，10 到 14天后，使用自动集落计数器计数。


    (Only for Reference)
动物实验：

[2]
+ 展开
  • Animal Models: 携带 SW620移植瘤的雌性裸鼠
  • Formulation: 无菌 0.9% NaCl溶液
  • Dosages: 10 mg/kg
  • Administration: 腹腔注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 4 mg/mL warmed (9.67 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)：
5% DMSO+30% PEG 300+5% Tween 80+ddH2O 		2mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 413.49
化学式

C25H19NO3S
CAS号 503468-95-9
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量：

总分子量：g/mol

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1：

    Could you please suggest formulations of the drug for in vivo injection?

  • 回答：

    We tested the following formulation for in vivo use, 4% DMSO+30% PEG 300+5% Tween 80+ddH2O up to 1mg/mL. It is a clear solution.

  • 问题 2：

    Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

  • 回答：

    Slight color variation due to different processing is normal and usually doesn't interfere with the function.

Selleck产品目录册

DNA-PK Signaling Pathway Map

DNA-PK Inhibitors with Unique Features

  • 非特异性的DNA-PK抑制剂

    PI-103 : DNA-PK, IC50=23 nM; p110α/β/δ/γ, IC50=2 nM/3 nM/3 nM/15 nM; mTOR, IC50=30 nM.

  • 活性最高的DNA-PK抑制剂

    PIK-75 : DNA-PK, IC50=2 nM.

  • 最新的DNA-PK抑制剂

    KU-0060648 : Dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 μM.

  • 经典的DNA-PK抑制剂

    NU7026 : Potent DNA-PK inhibitor with IC50 of 0.23 μM, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR.

相关DNA-PK产品

  • CHIR-99021 (CT99021) New

    CHIR-99021 (CT99021)是一种GSK-3α和GSK-3β抑制剂， IC50分别为10 nM and 6.7 nM。CHIR99201对CDKs没有交叉反应性，对GSK-3β的选择性是对CDKs选择性的350倍。

  • Dorsomorphin (Compound C) New

    Dorsomorphin (Compound C)是一种有效的，可逆选择性 AMPK 抑制剂，无细胞试验中 Ki 为 109 nM，对几个结构相关的激酶，包括ZAPK，SYK，PKCθ，PKA，和 JAK3没有显著的抑制作用。 也会抑制 I型 BMP receptor 活性。

  • MHY1485 New

    MHY1485是一种有效的，细胞渗透性 mTOR 激动剂，也能有效抑制 autophagy。

  • NU7026

    NU7026是一种有效的DNA-PK抑制剂，在无细胞试验中IC50为0.23 μM，作用于DNA-PK比作用于PI3K选择性高60倍，对ATM和ATR没有抑制活性

  • KU-0060648

    KU-0060648是DNA-PK和PI3Kα/β/δ双重抑制剂，IC50分别为8.6 nM和4 nM/0.5 nM/0.1 nM，对PI3Kγ抑制作用稍弱，IC50为0.59 μM。

  • Rapamycin (Sirolimus)

    Rapamycin (Sirolimus)是一种特定的 mTOR 抑制剂，在 HEK293细胞中，IC50 为 ~0.1 nM。

  • MK-2206 2HCl

    MK-2206 2HCl是一种高度选择性的Akt1/2/3抑制剂，在无细胞试验中IC50分别为8 nM/12 nM/65 nM；对250种其他蛋白激酶没有抑制活性。Phase 2。

    Features:MK-2206是第一个进入临床研究阶段的Akt小分子变构抑制剂。

  • CHIR-99021 (CT99021) HCl

    CHIR-99021 (CT99021) HCl是CHIR-99021的盐酸盐, 是GSK-3α/β抑制剂，IC50为10 nM/6.7 nM。 其对GSK-3的选择性比对Cdc2和ERK2高500倍以上。

  • LY294002

    LY294002 是首个合成的已知抑制PI3Kα/δ/β的小分子，在无细胞测定中IC50分别为 0.5 μM/0.57 μM/0.97 μM；在溶液中比在Wortmannin中稳定，也能够阻断自噬体的形成。它不仅能够结合class I PI3Ks和其他PI3K相关的激酶，还能够结合一些与PI3K家族无关的新型靶点。

    Features:LY294002是选择性的, 可渗透细胞的特定PI3K抑制剂，可作用于酶的ATP结合位点，且抑制自体吞噬的螯合作用。

  • 3-Methyladenine (3-MA)

    3-Methyladenine (3-MA)是一种选择性PI3K抑制剂，作用于Vps34和PI3Kγ，在 HeLa细胞中IC50分别为25 μM和60 μM；永久性抑制I型PI3K，但对III型PI3K的抑制是短暂的，也会阻断自噬体的形成。现配现用（加热助溶）。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID