PF-4708671

Pfizer辉瑞授权生产 目录号:S2163

仅限科研使用

PF-4708671是一种细胞渗透性p70 ribosomal S6 kinase(S6K1亚型)抑制剂,在无细胞试验中Ki/IC50为20 nM/160 nM,作用于S6K1比作用于S6K2选择性高400倍,作用于S6K1比作用于MSK1和RSK1/2选择性分别高4和20倍以上,是第一个报道的S6K1特异性抑制剂。

PF-4708671 Chemical Structure

CAS: 1255517-76-0

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 1574.66 现货
RMB 1179.06 现货
大包装 有超大折扣
大剂量询单有大折扣!

今日订购,明日送达 全国免运费 分装免费 分装成小规格产品(单支最小为1mg)
如1支10mg产品可分装为10支1mg产品

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的PF-4708671发表文献41篇:

产品安全说明书

S6 Kinase抑制剂选择性比较

相关S6 Kinase产品

生物活性

产品描述 PF-4708671是一种细胞渗透性p70 ribosomal S6 kinase(S6K1亚型)抑制剂,在无细胞试验中Ki/IC50为20 nM/160 nM,作用于S6K1比作用于S6K2选择性高400倍,作用于S6K1比作用于MSK1和RSK1/2选择性分别高4和20倍以上,是第一个报道的S6K1特异性抑制剂。
靶点
p70 S6K1 [1]
(Cell-free assay)
160 nM
体外研究

PF-4708671是一种哌嗪基嘧啶类似物,是第一个S6K1特异性抑制剂。PF-4708671不显著抑制紧密相关的S6K2亚型或一组其他AGC激酶 (Akt1, Akt2, PKA, PKCα, PKCϵ, PRK2, ROCK2, RSK1, RSK2 或SGK1)的活性。PF-4708671抑制S6K1介导的响应IGF-1(胰岛素样生长因子1)的S6蛋白的磷酸化,对PMA-诱导的底物磷酸化没有作用效果,底物与RSK (p90核糖体S6激酶)和MSK(丝分裂原和应激活化蛋白激酶)激酶高度相关。PF-4708671诱导S6K1的T型环和疏水性基序磷酸化,这种作用依赖于mTORC1 (mTOR复合体1)。PF-4708671不影响mTORC1的活性。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BHT-101 NV;mUJgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwOEKwNlQh|ryP MXfTRW5ITVJ?
UACC-893 NVzqcoh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTVwMUm4PFYh|ryP MkHBV2FPT0WU
A427 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGi5SJNKSzVyPUWuO|I2PjdizszN NYnXWoxvW0GQR1XS
OCUB-M NW\pOFRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfQNlc1UUN3ME22MlY3OTB{IN88US=> NVPRPVV7W0GQR1XS
SW684 NWTlWo85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTdwNUKyOlgh|ryP NIW4fFJUSU6JRWK=
SK-LMS-1 M3LYTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTlwMEGzNFIh|ryP MYHTRW5ITVJ?
CP50-MEL-B MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTlwM{C0NVkh|ryP NXK3eW5PW0GQR1XS
NCI-H1651 MlXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fON2lEPTB;MUCuNFI4PiEQvF2= NUSyV4dIW0GQR1XS
ABC-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3L4Z2lEPTB;MUCuNVA{PyEQvF2= Mlv0V2FPT0WU
OE19 NH:zcoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlviTWM2OD1zMD6xO|M{KM7:TR?= NH;LZYtUSU6JRWK=
DSH1 MnP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{frSmlEPTB;MUCuPFg4QSEQvF2= MmDuV2FPT0WU
SW13 MnPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml[3TWM2OD1zMT65N|E6KM7:TR?= MYTTRW5ITVJ?
MDA-MB-453 NWHCXHQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\JS4xKSzVyPUGyMlE3ODNizszN NX;ubIFYW0GQR1XS
647-V M1jPfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTF{LkO1PFIh|ryP Mke4V2FPT0WU
NCI-H2342 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkO1TWM2OD1zMj6zPVk2KM7:TR?= MXfTRW5ITVJ?
LB2241-RCC MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXyzb4c2UUN3ME2xNk42Pzd7IN88US=> MnPjV2FPT0WU
UACC-257 NHvYdW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrj[mhrUUN3ME2xN{41PDV|IN88US=> MYTTRW5ITVJ?
NCI-H661 NXjSOYZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4q0eWlEPTB;MUOuOlQ1QSEQvF2= MWHTRW5ITVJ?
FADU NUnhdpk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTF|Lk[5PVIh|ryP Ml7GV2FPT0WU
A2780 M{XmWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TCSmlEPTB;MUOuPFA1OSEQvF2= NHHjWXhUSU6JRWK=
NCI-H1793 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3vWVZKSzVyPUG0MlQxQDVizszN MYXTRW5ITVJ?
TE-8 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7YTnFGUUN3ME2xOU4{PDZ3IN88US=> NInaO3pUSU6JRWK=
HGC-27 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPRdYVKSzVyPUG2MlE3PDRizszN NUXCRmhqW0GQR1XS
MMAC-SF M332NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV[2d2h[UUN3ME2xO{4{PzJ5IN88US=> MmLuV2FPT0WU
Calu-6 NHu1eYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPuTXpKSzVyPUG4MlE2OTNizszN MnrtV2FPT0WU
HUTU-80 NYPncG5tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTF6LkO5OVkh|ryP M4HnNXNCVkeHUh?=
SAS MkfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnLZ5NpUUN3ME2xPE43PDV3IN88US=> NVLQWFU{W0GQR1XS
IST-MES1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoOzTWM2OD1zOD62OVA5KM7:TR?= NFfLVJVUSU6JRWK=
C3A M2fKcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTF6Lke5NVkh|ryP NIPkTo9USU6JRWK=
ES3 NHj4WnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7zeIZ3UUN3ME2xPE45OzZ2IN88US=> MUjTRW5ITVJ?
HSC-2 M3nJSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTKTWM2OD1zOT62OVQyKM7:TR?= M4HESXNCVkeHUh?=
T47D NXvneVBqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fJcWlEPTB;MkCuNVQ5PSEQvF2= MlHFV2FPT0WU
EW-7 MorjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPnVXpWUUN3ME2yNE45PTh6IN88US=> M2faUXNCVkeHUh?=
LN-405 M{\EVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2m1eGlEPTB;MkCuPFk3PSEQvF2= M{nLTXNCVkeHUh?=
U031 NWP1[phxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnuSFhlUUN3ME2yNU41QDB{IN88US=> MWjTRW5ITVJ?
A549 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4qwU2lEPTB;MkGuPFQ6OSEQvF2= Mm[1V2FPT0WU
RMG-I MmG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nr[GlEPTB;MkKuNlY3QCEQvF2= NX\sTmV7W0GQR1XS
BT-474 NF\pb5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTLXIF6UUN3ME2yNk43PTVzIN88US=> NUjnOmVHW0GQR1XS
NB69 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PtS2lEPTB;MkOuNVUzKM7:TR?= MWrTRW5ITVJ?
NB7 NUnzXmlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DPOWlEPTB;MkSuNVg5KM7:TR?= M33BOnNCVkeHUh?=
HCC1569 MoP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVi5c4RRUUN3ME2yOE43OTJ3IN88US=> NUPm[m1FW0GQR1XS
MEL-JUSO NGTicYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXJTWM2OD1{ND62PVA5KM7:TR?= M2LnfXNCVkeHUh?=
MDA-MB-175-VII NUflTHdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zn[mlEPTB;MkWuNlUyPyEQvF2= M2DHc3NCVkeHUh?=
HCC1419 M3jVUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnroTWM2OD1{NT62NFA{KM7:TR?= MnvxV2FPT0WU
Ca9-22 NXLvb44{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HTVWlEPTB;MkWuOlQ{OiEQvF2= NUK5OnZyW0GQR1XS
KGN MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTJ3Lke1OFch|ryP MUjTRW5ITVJ?
LB373-MEL-D MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1S3e2lEPTB;Mk[uNVk{QCEQvF2= NFz3[2JUSU6JRWK=
NCI-H1755 MkTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTVPYtbUUN3ME2yOk45QDRzIN88US=> NUDTfod1W0GQR1XS
D-423MG MnrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLLTWM2OD1{Nz6wO|E2KM7:TR?= MXLTRW5ITVJ?
DK-MG M1nNV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTHTWM2OD1{OD63PFQ3KM7:TR?= NWnhZ5dGW0GQR1XS
NCI-H1623 NXzMSYtyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorJTWM2OD1{OD64N|QzKM7:TR?= MUXTRW5ITVJ?
KU-19-19 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDsZpdKSzVyPUK4Mlk6PSEQvF2= NUXnOYhOW0GQR1XS
C-33-A MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDVbVNKSzVyPUK5MlIyQThizszN NWLNPYFHW0GQR1XS
SCC-4 MnjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3z6WGlEPTB;M{CuN|M2PCEQvF2= MV;TRW5ITVJ?
MG-63 M1vtS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTNyLkW5PVQh|ryP NUnmVoNvW0GQR1XS
LNCaP-Clone-FGC NUPsdmYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmP4TWM2OD1|MT60PVIyKM7:TR?= MVXTRW5ITVJ?
CAPAN-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1G3SWlEPTB;M{GuOVI5PiEQvF2= MnPrV2FPT0WU
GI-ME-N NWnYc4ZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3vRXNKSzVyPUOxMlU{PTNizszN MYTTRW5ITVJ?
RERF-LC-MS MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTN{Lk[3OFch|ryP MXrTRW5ITVJ?
KLE MlHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTN|LkSzN|Qh|ryP MoDRV2FPT0WU
KNS-81-FD NYjHTlFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jL[GlEPTB;M{OuOVAxQCEQvF2= M3PabnNCVkeHUh?=
DOK M4nJ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIGye2VKSzVyPUO0MlY3OTJizszN MV3TRW5ITVJ?
ACHN NIrCV3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUmz[VMzUUN3ME2zOU4yPTh6IN88US=> NXP6Um56W0GQR1XS
KYSE-520 M3qybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYThNlU4UUN3ME2zOU4zOzZzIN88US=> M2G0dHNCVkeHUh?=
SBC-5 NFTweoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHu4bYdKSzVyPUO1MlUyOTZizszN M4DyVHNCVkeHUh?=
NCI-H28 Ml7oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjJZmRFUUN3ME2zOU43Pjl3IN88US=> M3XrNXNCVkeHUh?=
ES7 NH:zcWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoK5TWM2OD1|Nj6yNlQ6KM7:TR?= NV74fotkW0GQR1XS
A172 Ml30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3Rb4xZUUN3ME2zOk41OTh5IN88US=> NUfENI0yW0GQR1XS
UM-UC-3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfObWxUUUN3ME2zO{45PzR4IN88US=> MknFV2FPT0WU
LXF-289 NG[yTWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTN6LkCwOFch|ryP MY\TRW5ITVJ?
KP-4 NGLNUVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\UTWM2OD1|OD60O|M6KM7:TR?= NUKxO2N4W0GQR1XS
TE-1 NYGxXW5tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTN7Lk[1PFkh|ryP Mn7iV2FPT0WU
G-402 M{LSdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTRyLkC2NUDPxE1? NWXZNotRW0GQR1XS
786-0 MnrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTRyLkmwPVYh|ryP NWfvcW9FW0GQR1XS
K5 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknpTWM2OD12MT6zOlg3KM7:TR?= M4Xk[nNCVkeHUh?=
SK-N-DZ MkTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXiyTo5mUUN3ME20NU4{QDJ|IN88US=> MknuV2FPT0WU
OVCAR-4 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXBVo9oUUN3ME20NU44PTZ6IN88US=> NWPVWoZJW0GQR1XS
T84 M1LlXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnztTWM2OD12Mj6xNlY{KM7:TR?= NHiwPI5USU6JRWK=
GCIY NG\BXpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWe0PIl7UUN3ME20N{4xQDB|IN88US=> NILaV2tUSU6JRWK=
BB49-HNC M4\aZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTR|LkOzOFgh|ryP Mo\oV2FPT0WU
SNU-C2B M3fwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\CWVdKSzVyPUSzMlY1OzZizszN M{PoNHNCVkeHUh?=
TE-6 M3O0d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjR[oZqUUN3ME20N{45QDl2IN88US=> NI\qWXVUSU6JRWK=
23132-87 MkDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfKeIdKSzVyPUS0MlI6PzhizszN NIPz[GFUSU6JRWK=
DMS-53 MoHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEOyZoVKSzVyPUS0MlM{QDRizszN M1HvUXNCVkeHUh?=
ONS-76 NV2yb5ZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTR2Lke2OlEh|ryP NFKwbJpUSU6JRWK=
DMS-273 MofSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\oTmpKUUN3ME20OE46PDNizszN M4TPfHNCVkeHUh?=
COLO-824 NUm2UphbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIG3PW5KSzVyPUS1Mlg4PzVizszN NIrqb4dUSU6JRWK=
DMS-114 M3HaXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nzeWlEPTB;NEWuPFkzPyEQvF2= NV7ROWRWW0GQR1XS
YKG-1 Mn\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTR4LkCzOVUh|ryP MlnkV2FPT0WU
RH-18 NFzyTXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTR4LkO3N|Mh|ryP NGXnS5JUSU6JRWK=
NCI-H1355 NIPFW4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzoTXB4UUN3ME20Ok43OThizszN MVPTRW5ITVJ?
NCI-H2170 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfnTWM2OD12Nz63OVg1KM7:TR?= NGPRZWlUSU6JRWK=
OC-314 Mk\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1j2cGlEPTB;NEeuPFQ4QCEQvF2= MoTlV2FPT0WU
NCI-H2030 NFrXd2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DHXmlEPTB;NEeuPFkxPiEQvF2= M4XlSnNCVkeHUh?=
22RV1 NF;ufodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2GwSWlEPTB;NEeuPVAyPSEQvF2= M2r4O3NCVkeHUh?=
G-401 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTR6LkS0NVUh|ryP MoL3V2FPT0WU
YAPC M1PhfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjzXGR7UUN3ME20PU45ODd|IN88US=> M4G3e3NCVkeHUh?=
SW1573 M2f2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTVyLkK0N|Uh|ryP NX\vc|Y6W0GQR1XS
COLO-792 M1rN[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHZUXVKSzVyPUWwMlYzOzdizszN M{[0[nNCVkeHUh?=
KNS-62 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTVyLke1NFgh|ryP M3zYUnNCVkeHUh?=
NB5 NYH6bJRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVz6V3dZUUN3ME21NU41PTB7IN88US=> NWe1cIUyW0GQR1XS
CP66-MEL MoH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTVzLk[0NFgh|ryP MY\TRW5ITVJ?
CaR-1 M{DuZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnXNVRKSzVyPUWyMlA3ODZizszN M{GxWXNCVkeHUh?=
CAL-54 M4\5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvrfm9KSzVyPUWyMlEyODJizszN NGPFdZlUSU6JRWK=
8305C M2n2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULMdYpoUUN3ME21Nk4{OTVizszN M3mxUHNCVkeHUh?=
Calu-3 NFnIPHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTV{LkO3N|Mh|ryP NHHLS2xUSU6JRWK=
AU565 MmPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV63PVdJUUN3ME21Nk42PTB7IN88US=> M2LndXNCVkeHUh?=
CW-2 NIHpV2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHv4W|ZKSzVyPUWyMlg3PTRizszN MWPTRW5ITVJ?
BEN NWLte|ZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jVfWlEPTB;NUOuO|g3OiEQvF2= NX21Z5V3W0GQR1XS
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JAR MljxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlWyTWM2OD14NT61OVE3KM7:TR?= NIraVlVUSU6JRWK=
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GCT MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3KT2p3UUN3ME22O{4xPDR|IN88US=> NFHyN29USU6JRWK=
NOS-1 M3LpO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUC1fZprUUN3ME22O{43QDZ5IN88US=> MYnTRW5ITVJ?
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SHP-77 NFjLOo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2WxNGlEPTB;N{KuNVE6KM7:TR?= NVjGd|ZpW0GQR1XS
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LK-2 NYDHWFhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlW2TWM2OD15Mj64OlEzKM7:TR?= MoLhV2FPT0WU
U-2-OS MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTd|LkG4Nlgh|ryP MYnTRW5ITVJ?
KYSE-150 M2jNXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjkWmNKSzVyPUezMlYyOThizszN Mk\TV2FPT0WU
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HT-1080 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;uXmlEPTB;N{SuNlU4PCEQvF2= MVrTRW5ITVJ?
NCI-H1437 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTd2Lk[zNlYh|ryP NUP1d3ROW0GQR1XS
HPAF-II MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXS2c3dxUUN3ME23OE43PDF3IN88US=> NX;zdpdHW0GQR1XS
Becker MoHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\ZXYVKSzVyPUe1MlEyODVizszN MlnpV2FPT0WU
PANC-10-05 NVLUSnlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTd3LkK4OlUh|ryP NVfXSXZPW0GQR1XS
TYK-nu NEnsXHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\CN3VKSzVyPUe1MlMyODJizszN MYLTRW5ITVJ?
SKG-IIIa NXHuWWI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLwb2NKSzVyPUe1MlM{PDFizszN NWrWbpBEW0GQR1XS
NCI-H1993 NXH1R3ZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTd3LkezPVch|ryP NYf0TmpWW0GQR1XS
S-117 NEPxSYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfSN49KSzVyPUe1Mlc2PSEQvF2= MXLTRW5ITVJ?
HuO9 MlW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTLUm5KSzVyPUe2MlAxPDhizszN NHLJNphUSU6JRWK=
CAL-51 M1rxRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmG3TWM2OD15Nj6xNFA3KM7:TR?= MkjSV2FPT0WU
BT-20 MoryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjJTVFKSzVyPUe2MlIyPjhizszN M2XjPXNCVkeHUh?=
LB831-BLC M{Hnb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfnTWM2OD15Nj6zNlE4KM7:TR?= NXPLeVk{W0GQR1XS
LB1047-RCC M4nzZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTd4Lke2NVkh|ryP NUXvR5EyW0GQR1XS
ES8 M3zWPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnkR4IzUUN3ME23PE4xODd|IN88US=> M2HwT3NCVkeHUh?=
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NCI-H226 Mn;tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LTW2lEPTB;N{iuNVMyPSEQvF2= Mon3V2FPT0WU
IGROV-1 NEjtWpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TD[WlEPTB;N{iuOVU2KM7:TR?= M3W4d3NCVkeHUh?=
BHY Ml73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrJTGdKSzVyPUe5MlU6PiEQvF2= NHHMN|dUSU6JRWK=
MKN45 M2LRSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRThyLkOxO|Qh|ryP MYXTRW5ITVJ?
IA-LM NWO2SZF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDBdlNQUUN3ME24NE4{PTFzIN88US=> NF;jbIVUSU6JRWK=
WM-115 M{CwPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRThzLkSxNVQh|ryP MmXSV2FPT0WU
VMRC-RCZ MkTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRThzLkS0NlUh|ryP NWm1fVE3W0GQR1XS
NCI-H2291 Mo\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPLTWM2OD16MT62PFQzKM7:TR?= MmPJV2FPT0WU
MCF7 NInwT2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTmTWM2OD16Mz6yPFk4KM7:TR?= NH62VWJUSU6JRWK=
639-V MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vWPWlEPTB;OESuOlEzQSEQvF2= M1\G[3NCVkeHUh?=
RT4 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nPVWlEPTB;OEWuNlQxOyEQvF2= NHnES2hUSU6JRWK=
NCI-H2405 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnkSJVsUUN3ME24OU4zQTl5IN88US=> NYS3[oc{W0GQR1XS
CAL-33 MnWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVq5[W9pUUN3ME24OU43OzF3IN88US=> MUPTRW5ITVJ?
BT-549 NXj1U5hIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfifIFKSzVyPUi1Mlk{QDJizszN NFLUcm9USU6JRWK=
HT-1197 NVXj[GVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\VVZBKSzVyPUi4MlExPzdizszN M3TNUnNCVkeHUh?=
G-361 M1PTT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTh6LkG0O|Qh|ryP M2DyVXNCVkeHUh?=
LS-411N NIj1T4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTh7LkOzPFgh|ryP MlnoV2FPT0WU
HT-144 NWfyUndXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS0UndjUUN3ME24PU42QTl{IN88US=> NGGxSXlUSU6JRWK=
DJM-1 NVPDOIcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVOyZnlsUUN3ME24PU45QDR3IN88US=> MUHTRW5ITVJ?
CAL-12T NGfH[VJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHJTWM2OD17MD63PFk2KM7:TR?= MliwV2FPT0WU
MKN7 NIDD[|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnK4TWM2OD17MT6zOVUyKM7:TR?= MoDnV2FPT0WU
HuP-T3 Mmq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnocWFKSzVyPUm2MlExODRizszN NWL3bnhQW0GQR1XS
SK-MG-1 M3;IZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2roSmlEPTB;OU[uNVM1QCEQvF2= NXTt[XpxW0GQR1XS
NCI-H2347 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\DcVhKSzVyPUm4MlExPDJizszN M3fjUXNCVkeHUh?=
SW872 M{DYNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1H5UWlEPTB;MUCwMlQ2PiEQvF2= NFHOPYdUSU6JRWK=
COLO-829 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDK[pEyUUN3ME2xNFAvPTV|IN88US=> NEP6b|VUSU6JRWK=
MC-IXC NIGwPWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\pcVlkUUN3ME2xNFAvPjF3IN88US=> MoHOV2FPT0WU
Assay
Methods Test Index PMID
Western blot p-mTOR / mTOR / p-p70S6K / p70S6K pS6 / S6 / pS6K / S6K1 / pAKT / AKT 30423811 28626016
Growth inhibition assay Cell viability 30423811

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度(25°C)

体外

体内

从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
30% PEG400+0.5% Tween80+5% propylene glycol

30 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 390.41
化学式

C19H21F3N6

CAS号 1255517-76-0
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

* 必填项

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常见问题及建议解决方法

问题 1:
Whether the in vivo formula "30% PEG400+0.5% Tween80+5% Propylene glycol" for S2163 is suitable for i.p. or not?

回答:
The formula "30% PEG400+0.5% Tween80+5% Propylene glycol" on our website is an oral one. It is a suspension.