MK-8776 (SCH 900776)

For research use only. Not for use in humans.

目录号:S2735

MK-8776 (SCH 900776) Chemical Structure

CAS No. 891494-63-6

MK-8776 (SCH 900776)是一种选择性Chk1抑制剂,无细胞试验中IC50为3 nM,比作用于Chk2选择性高500倍。Phase 2。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1921.21 现货
RMB 1733.35 现货
RMB 3015.42 现货
RMB 7966.05 现货
RMB 20229.3 现货
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客户使用Selleck生产的MK-8776 (SCH 900776)发表文献38篇:

产品安全说明书

Chk抑制剂选择性比较

生物活性

产品描述 MK-8776 (SCH 900776)是一种选择性Chk1抑制剂,无细胞试验中IC50为3 nM,比作用于Chk2选择性高500倍。Phase 2。
靶点
Chk1 [1]
(Cell-free assay)
CDK2 [1]
(Cell-free assay)
3 nM 0.16 μM
体外研究

SCH 900776是Chk2和CDK2的低效抑制剂,IC50分别为1.5 μM 和 0.16 μM。SCH 900776对细胞色素P450人肝微粒体亚型1A2,2C9,2C19,2D6,和3A4没有显著的抑制作用。羟基脲下暴露24小时后,SCH 900776诱导DNA复制能力剂量依赖性损失。SCH 900776增强γ-H2AX对羟基脲,5-氟尿嘧啶,和阿糖孢苷的响应。与抗代谢物结合,SCH 900776在2小时内诱导γ-H2AX的累积,表明复制叉瓦解,并且双链DNA断裂。此外,SCH 900776以剂量依赖的方式抑制Chk1 pS296自磷酸化的积累。增殖的WS1细胞暴露于SCH 900776,与Chk1 pS345快速的,剂量依赖性聚集相关,表明正常细胞的循环群诱导Chk1 pS345在暴露于SCH 900776后,是一部分无效循环,这也许通过AT-家族激酶和DNA-PK驱动。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
U251 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3u2e|IxOC9{MECwJI5O MWeyOEBp M1XBeIRm[3KnYYPld{B1cGViSVO1NEBw\iCJZX3jbZRi[mmwZR?= NFzqO5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO1PVUzPid-MkSzOVk2OjZ:L3G+
HCT115 NUPFS3R1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnIc3MzODBxMkCwNEBvVQ>? MnLlNlQhcA>? NWHH[WVb\GWlcnXhd4V{KHSqZTDJR|UxKG:oIFflcYNqfGGkaX7l NX7NSYV2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOVk2OjZpPkK0N|U6PTJ4PD;hQi=>
SW620 MojyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYCyNFAwOjByMDDuUS=> NYPWbFc4OjRiaB?= M1XKeYRm[3KnYYPld{B1cGViSVO1NEBw\iCJZX3jbZRi[mmwZR?= MljCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|NUm1NlYoRjJ2M{W5OVI3RC:jPh?=
IGROV-1 M2XDe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV2yNFAwOjByMDDuUS=> Mm\kNlQhcA>? Mn\S[IVkemWjc3XzJJRp\SCLQ{WwJI9nKEenbXPpeIFjcW6n NIXhNnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO1PVUzPid-MkSzOVk2OjZ:L3G+
HCT116 NXG4bGhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjuW|lUOjByL{KwNFAhdk1? M1fXOFI1KGh? M3HBfIRm[3KnYYPld{B1cGViSVO1NEBw\iCJZX3jbZRi[mmwZR?= NHrpXYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO1PVUzPid-MkSzOVk2OjZ:L3G+
MCF10A MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;CWoszODBxMkCwNEBvVQ>? NHPJUpQzPCCq MoPJ[IVkemWjc3XzJJRp\SCLQ{WwJI9nKEenbXPpeIFjcW6n M2q3O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{W5OVI3Lz5{NEO1PVUzPjxxYU6=
MiaPaCa-2 M2jqfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPENnIxOjByL{KwNFAhdk1? NWPnOJF3OjRiaB?= NUX6VnRp\GWlcnXhd4V{KHSqZTDJR|UxKG:oIFflcYNqfGGkaX7l NIPSepM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO1PVUzPid-MkSzOVk2OjZ:L3G+
MDA-MB-231 NFrVTWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fhflIxOC9{MECwJI5O NWnDfpk3OjRiaB?= NIrGUWpl\WO{ZXHz[ZMhfGinIFnDOVAhd2ZiR3XtZ4l1[WKrbnW= MljnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|NUm1NlYoRjJ2M{W5OVI3RC:jPh?=
HCC2998 MnTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYOyNFAwOjByMDDuUS=> Mme1NlQhcA>? MljY[IVkemWjc3XzJJRp\SCLQ{WwJI9nKEenbXPpeIFjcW6n Mn7XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|NUm1NlYoRjJ2M{W5OVI3RC:jPh?=
U87 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUGyNFAwOjByMDDuUS=> NXuyWJNGOjRiaB?= NY[0O|db\GWlcnXhd4V{KHSqZTDJR|UxKG:oIFflcYNqfGGkaX7l NEHSS289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO1PVUzPid-MkSzOVk2OjZ:L3G+
MDA-MB-435 MljYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPENlAxNzJyMECgcm0> MljlNlQhcA>? MoXu[IVkemWjc3XzJJRp\SCLQ{WwJI9nKEenbXPpeIFjcW6n NGn6d2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO1PVUzPid-MkSzOVk2OjZ:L3G+
SNB19 NGjpWoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVX0TplDOjByL{KwNFAhdk1? MoHiNlQhcA>? NYPJdGtm\GWlcnXhd4V{KHSqZTDJR|UxKG:oIFflcYNqfGGkaX7l MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN3OUWyOkc,OjR|NUm1NlY9N2F-
U20S M{DWZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnpNlAxNzJyMECgcm0> NGf6dnkzPCCq MX;k[YNz\WG|ZYOgeIhmKEmFNUCgc4YhT2WvY3n0ZYJqdmV? MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN3OUWyOkc,OjR|NUm1NlY9N2F-
A498 MlHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\k[48zODBxMkCwNEBvVQ>? MljnNlQhcA>? MXHk[YNz\WG|ZYOgeIhmKEmFNUCgc4YhT2WvY3n0ZYJqdmV? Mnn2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|NUm1NlYoRjJ2M{W5OVI3RC:jPh?=
TK10 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jzXlIxOC9{MECwJI5O MUGyOEBp M3;FfoRm[3KnYYPld{B1cGViSVO1NEBw\iCJZX3jbZRi[mmwZR?= M12zeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{W5OVI3Lz5{NEO1PVUzPjxxYU6=
AsPC-1 NHu3S4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoX4NlAxNzJyMECgcm0> M2PTe|I1KGh? MlPk[IVkemWjc3XzJJRp\SCLQ{WwJI9nKEenbXPpeIFjcW6n MlT4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|NUm1NlYoRjJ2M{W5OVI3RC:jPh?=
H23 M4\UWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfiPGg2ODBibl2= NYfnfmxPOjRiaB?= NXLVV21qTE2VTx?= Mk\E[Y5p[W6lZYOgeIhmKGOqZX3vd4Vve2m2aYrheIlwdiC2bzDQUXg> NFXBcXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGxN|U1QSd-MkSxNVM2PDl:L3G+
H1437 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYC1NFAhdk1? MlnwNlQhcA>? NHXDc4xFVVOR NXG0NIQ6\W6qYX7j[ZMhfGinIHPo[Y1we2Wwc3n0bZpifGmxbjD0c{BRVVh? NVXyV5NYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxNVM2PDlpPkK0NVE{PTR7PD;hQi=>
H1993 M4\TcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmm4OVAxKG6P NH32W4wzPCCq MlTKSG1UVw>? NFqyXZBmdmijbnPld{B1cGViY3jlcY9{\W6|aYTpfoF1cW:wIITvJHBOYA>? MmLhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzMUO1OFkoRjJ2MUGzOVQ6RC:jPh?=
H1299 NV7TTol6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUO2dXhHPTByIH7N NYfDWnA{OjRiaB?= MXzEUXNQ NIfSR3NmdmijbnPld{B1cGViY3jlcY9{\W6|aYTpfoF1cW:wIITvJHBOYA>? MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDFzM{W0PUc,OjRzMUO1OFk9N2F-
AsPC-1 MmnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnpZ4JjOTBvMUCwNEBvVQ>? MkTyNlQuPDiq MnfQ[Y5p[W6lZYOgeIhmKGOqZX3vd4Vve2m2aYrheIlwdiC2bzDn[Y1kcXSjYnnu[S=> M3rnZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEC0OFIzLz5{M{iwOFQzOjxxYU6=
MiaPaCa-2 NGjZOlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPsZmUyOTBvMUCwNEBvVQ>? NWDYUIliOjRvNEjo Mke2[Y5p[W6lZYOgeIhmKGOqZX3vd4Vve2m2aYrheIlwdiC2bzDn[Y1kcXSjYnnu[S=> NEO3UoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iwOFQzOid-MkO4NFQ1OjJ:L3G+
BxPC-3 M3XxRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTabIVQOTBvMUCwNEBvVQ>? NX\1[HBLOjRvNEjo MUHlcohidmOnczD0bIUh[2inbX;z[Y5{cXSrenH0bY9vKHSxIHflcYNqfGGkaX7l NUH0TIJXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NFQ1OjJpPkKzPFA1PDJ{PD;hQi=>
SKOV3 NFrKV2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYiwO5dbOC5|INM1US=> M2nhc|gh\A>? NEDWR3J{\W6|aYTpfoV{KHSqZTDj[YxtKGyrbnXzJJRwKGenbXPpeIFjcW6nwrC= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV2OEK2PUc,OjN3NEiyOlk9N2F-
OVCAR-8 NHzVVYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjjO4g4OC5|INM1US=> MXO4JIQ> MonOd4Vve2m2aYrld{B1cGViY3XscEBtcW6nczD0c{Bo\W2laYThZolv\cLi NXnCVmNxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1OFgzPjlpPkKzOVQ5OjZ7PD;hQi=>
MV-4-11 NF3leIZCeG:ydH;zbZMhSXO|YYm= MWOxNFAuPzByIH7N NIX1fJE1QCCq NImxZnBqdmS3Y3XzJIFxd3C2b4Ppd{Bld3OnIHTldIVv\GWwdHz5 MoG2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3M{[3NlEoRjJ|NUO2O|IyRC:jPh?=
U937 M2PTdGFxd3C2b4Ppd{BCe3OjeR?= NV7TWWVYOTByLUewNEBvVQ>? MmKwOFghcA>? M33ofolv\HWlZYOgZZBweHSxc3nzJIRwe2ViZHXw[Y5l\W62bIm= NF7JbY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{WzOlczOSd-MkO1N|Y4OjF:L3G+
MOLM-13  NUPsfWtESXCxcITvd4l{KEG|c3H5 NWjk[WxqOTByLUewNEBvVQ>? MnTlOFghcA>? M1q0S4lv\HWlZYOgZZBweHSxc3nzJIRwe2ViZHXw[Y5l\W62bIm= NXWxdmFJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1N|Y4OjFpPkKzOVM3PzJzPD;hQi=>
A2058  Ml:zR4VtdCCYaXHibYxqfHliQYPzZZk> MoLuN|cvPS1|MECgcm0> NGn1UJc4OiCq M3rrfGROW09? NHW0[5Fz\WS3Y3XzJJRp\SCPSz2xO|c2KEWFNUFCpIJ6KDVvZn;s[EB1dyCjbjDheoVz[WenIH;mJFQ2KG6P NH63R3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G0PFY5PCd-MkOxOFg3QDR:L3G+
H2009 MnfyR4VtdCCYaXHibYxqfHliQYPzZZk> NHLJUXU2ODBibl2= M4\ScFczKGh? NEKxT3BFVVOR MmHmdoV{fWy2czDpckBIOS:VLYDoZZNmKGGlY4XteYxifGmxbjDjc41jcW6nZDD3bZRpKE2NLUG3O|U> NFPGSlY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G0PFY5PCd-MkOxOFg3QDR:L3G+
Su.86.86 NFraPG9E\WyuIG\pZYJqdGm2eTDBd5NigQ>? MmXtOVAxKG6P NUXQNZJsPzJiaB?= MXTEUXNQ MWXy[ZN2dHS|IHnuJGcyN1NvcHjhd4Uh[WOldX31cIF1cW:wIHPvcYJqdmWmIIfpeIghVUtvMUe3OS=> M2LSelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MUS4Olg1Lz5{M{G0PFY5PDxxYU6=
HRE MXPD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MVq1NFAhdk1? Ml24O|IhcA>? NH3zXIVFVVOR Mn\sdoV{fWy2czDpckBIOS:VLYDoZZNmKGGlY4XteYxifGmxbjDjc41jcW6nZDD3bZRpKE2NLUG3O|U> NG\xN|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G0PFY5PCd-MkOxOFg3QDR:L3G+
HMEC NHS1Vm1E\WyuIG\pZYJqdGm2eTDBd5NigQ>? MUG1NFAhdk1? MlPMO|IhcA>? MlzBSG1UVw>? NXjRWnZKemW|dXz0d{BqdiCJMT;TMZBp[XOnIHHjZ5VufWyjdHnvckBkd22kaX7l[EB4cXSqIF3LMVE4PzV? MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF2OE[4OEc,OjNzNEi2PFQ9N2F-
U2OS  NUn5dohNTnWwY4Tpc44hSXO|YYm= M1HYSVIhyrWP M{TmbVAuOjRiaB?= NVu0TZZJcW6mdXPld{BxcG:|cHjvdplt[XSrb36gc4YhS2itMTDheEB{\XKrbnWgN|Q2KGG2IHLveIgh[2:wY3XueJJifGmxboOgZZMh\WG{bImgZZMhOiCqIHHmeIVzKGGmbXnubZN1emG2aX;u Mo[yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7M{exOFcoRjJ{OUO3NVQ4RC:jPh?=
U2OS  MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXJcG0xNTFyINM1US=> NVvxeVNxOjRxNEigbC=> MVXpcohq[mm2czDj[YxtKGe{b4f0bEBld3OnIHTldIVv\GWwdHz5 MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl|N{G0O{c,OjJ7M{exOFc9N2F-
U937 MWrGeY5kfGmxbjDBd5NigQ>? MVixNFAuPTByIH7N NIfkPVk1KGkEoB?= NXW3NJhS\GWlcnXhd4V{KHSqZTDjfZRiemGkaX7lMYlv\HWlZXSgR4hsOSCjdYTvdIhwe3Cqb4L5cIF1cW:wIHH0JHNmejJ7NtMgZY5lKHC{ZY\lcpR{KEOmY{K1RUBld3ewcnXneYxifGmxbh?= M{HKNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OE[5PFY6Lz5{Mki2PVg3QTxxYU6=
U937 NF3w[XNHfW6ldHnvckBCe3OjeR?= Mn[4NVAxKG6P NV\HNG1GPCCqwrC= MWry[ZZmenOnczD0bIUh[3m2YYLhZolv\S2rbnT1Z4VlKGmwaHnibZRqd25ib3dCpFNJNXSqeX3p[Ilv\SCrbnPvdpBwemG2aX;uJIlvfG9iRF7B NH3leZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki2PVg3QSd-MkK4Olk5Pjl:L3G+
U937 NETTTJZHfW6ldHnvckBCe3OjeR?= MkHSNVAxNTVyMDDuUS=> NEntcXE1KGkEoB?= M{jUfIlv\HWlZYOgbY5kemWjc3XkJJBpd3OyaH;yfYxifGmxbjDv[kBJOkG[ MorxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6Nkm4OlkoRjJ{OE[5PFY6RC:jPh?=
HL-60 M1j5emFxd3C2b4Ppd{BCe3OjeR?= MXyzNE8yODBxM{CwJI5O NWXYemF[OjRiaB?= NVHsXW5UTE2VTx?= MWHlcohidmOnczDjfZRiemGkaX7lMYlv\HWlZXSgZZBweHSxc3nz MnnaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6Nkm4OlkoRjJ{OE[5PFY6RC:jPh?=
ML-1 M4T2W2Fxd3C2b4Ppd{BCe3OjeR?= M{Dhd|I2NzVyL{GwNEBvVQ>? MljkNlQhcA>? NF7ac3pFVVOR NFPqSXpmdmijbnPld{BkgXSjcnHibY5mNWmwZIXj[YQh[XCxcITvd4l{ MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh4OUi2PUc,OjJ6Nkm4Olk9N2F-
HCT116 MYfGeY5kfGmxbjDBd5NigQ>? MUOxJOK2VQ>? MoDHNlQhcA>? MVLhZpJw\2G2ZYOgc4Yh[2WubDDjfYNt\SCjcoLld5TDqA>? MnS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3MUC1OlAoRjJ{NUGwOVYxRC:jPh?=
U2OS M{C5dWZ2dmO2aX;uJGF{e2G7 M4\3[|EhyrWP NIXXdWwzPCCq M{PRSIFjem:pYYTld{Bw\iClZXzsJIN6[2ynIHHydoV{fMLi MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjVzMEW2NEc,OjJ3MUC1OlA9N2F-
Sf9 MlTRSpVv[3Srb36gZZN{[Xl? MV;Jcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IFPET|IwS3mlbHnuJGEh\XiycnXzd4VlKGmwIHnud4VkfCCVZkmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCdM{PQYU1CXFBiaX7jc5Jxd3KjdHnvckBqdnSxIHLpc5RqdnmuYYTl[EBpcXO2b37lJGgyKGGodHXyJFEhcHJiYomgcIlyfWmmIIPjbY51cWyuYYTpc44h[2:3boTpcoctKEmFNUCgQUAxNjF4IN88UU4> NXfvWXRmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPVQ3ODdpPkKxNFk1PjB5PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-chk1(ser345) / CDC25A ; 

PubMed: 27690219     


Western blots for H1299 and A549 cells treated with MK-8776 for various times and assessed for expression of p-chk1 (ser345) and CDC25A.

Cyclin E / pY15-CDK / γH2AX ; 

PubMed: 26595527     


The indicated cell lines were incubated with 2 μM of each drug for 6 h, then lysed and analyzed by western blotting. The top row reflects cells sensitive to MK-8776. The second row reflects cells that are also sensitive to MK-8776, but which fail to degrade cyclin E. The third row reflects MK-8776-resistant cell lines.

27690219 26595527
体内研究 相对于gemcitabine或SCH 900776单独给药,Gemcitabine给药30分钟后,4 mg/kg SCH 900776足以诱导γ-H2AX生物标志物,而8 mg/kg增强肿瘤药效动力学和退化响应。递增剂量的SCH 900776 (16 mg/kg和32 mg/kg)诱导肿瘤响应持续改进。重要的是,在BALB/c 小鼠体内,SCH 900776的剂量与强的生物标志物活化相关,而提高的肿瘤响应与gemcitabine对血液学指标增强的毒性无关。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

动物实验:[1]
- 合并
  • Animal Models: 皮下注射A2780 或 MiaPaCa2细胞的额雌性裸鼠
  • Dosages: ~50 mg/kg
  • Administration: 腹腔内注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 3 mg/mL (7.97 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
4% DMSO+30% propylene glycol
5 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 376.25
化学式

C15H18BrN7

CAS号 891494-63-6
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    I would like to know whether your product S2735 is the optically pure R enantiomer or whether it is a racemic mix.

  • 回答:

    Our S2735 MK-8776 (SCH 900776) is R enantiomer.

Chk Signaling Pathway Map

Chk Inhibitors with Unique Features

相关Chk产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID