SCH772984

目录号:S7101

仅限科研使用

SCH772984是一种新型特异性的ERK1/2抑制剂,无细胞试验中IC50分别为4 nM和1 nM, 对含有RAS或BRAF突变的癌细胞具有强大的功效。

SCH772984 Chemical Structure

CAS: 942183-80-4

规格 价格 库存 购买数量
RMB 2210.07 现货
RMB 11049.1 现货
RMB 44144.7 现货
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客户使用Selleck生产的SCH772984发表文献447篇:

产品安全说明书

ERK抑制剂选择性比较

生物活性

产品描述 SCH772984是一种新型特异性的ERK1/2抑制剂,无细胞试验中IC50分别为4 nM和1 nM, 对含有RAS或BRAF突变的癌细胞具有强大的功效。
特性 SCH772984不直接抑制MEK1, MEK2, BRAF, 或 CRAF酶活性。
靶点
ERK2 [1]
(Cell-free assay)
ERK1 [1]
(Cell-free assay)
1 nM 4 nM
体外研究

SCH772984是新型,选择性,ATP竞争性的ERK1/2抑制剂。SCH772984抑制ERK底物p90核糖体S6激酶(T359/S363 磷酸化-RSK)的磷酸化,这种作用存在剂量依赖性。SCH772984也能抑制ERK自身活化环中残基的磷酸化。SCH772984分别抑制约88%和49%BRAF突变型或RAS-突变型肿瘤细胞系,EC50值<500 nM。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
2P-ERK2 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDmTWM2OD1yLkK0JI5O NX3IWIM{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzOVA6OzFpPkK1N|UxQTNzPD;hQi=>
WM-266-4 M2PVS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfBTWM2OD1{MDDuUS=> NV;2dmtSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVQ5QThpPkKzOlE1QDl6PD;hQi=>
UACC-62 NWPFW5dUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWmwZogyUUN3ME2zNEBvVQ>? MlL6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUS4PVgoRjJ|NkG0PFk5RC:jPh?=
Colo-205 MnHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTN4IH7N MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzNEi5PEc,OjN4MUS4PVg9N2F-
SK-Mel-1 NU\0fWNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vQWmlEPTB;M{egcm0> M322RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkG0PFk5Lz5{M{[xOFg6QDxxYU6=
WiDr MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvBfopKSzVyPUO5JI5O M2nsWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkG0PFk5Lz5{M{[xOFg6QDxxYU6=
M14 NIj5WotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFn3UoxKSzVyPUS3JI5O M1yxS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkG0PFk5Lz5{M{[xOFg6QDxxYU6=
HT-29 NUfuOXZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnvSlVKSzVyPUWwJI5O NYnUUIFpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVQ5QThpPkKzOlE1QDl6PD;hQi=>
8505C NHTKdI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDseFZKSzVyPUWwJI5O MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzNEi5PEc,OjN4MUS4PVg9N2F-
HT-144 M{O0Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELYTVZKSzVyPU[wJI5O NYqxVlNORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVQ5QThpPkKzOlE1QDl6PD;hQi=>
SK-Mel-5 NE\2eFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojGTWM2OD14NjDuUS=> NVvD[ZdJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVQ5QThpPkKzOlE1QDl6PD;hQi=>
A375-SM MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIWxUZFKSzVyPUe1JI5O MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzNEi5PEc,OjN4MUS4PVg9N2F-
SK-Mel-28 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTh3IH7N MnnRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUS4PVgoRjJ|NkG0PFk5RC:jPh?=
LOX NVroS5RJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTFyMDDuUS=> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzNEi5PEc,OjN4MUS4PVg9N2F-
SK-Mel-3 Mlv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\kfJhZUUN3ME2xNVghdk1? NXLrfm5FRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVQ5QThpPkKzOlE1QDl6PD;hQi=>
K1 M4K2Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnP6TWM2OD1zM{Cgcm0> NWnnPXc{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVQ5QThpPkKzOlE1QDl6PD;hQi=>
Hs-695T MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37yNGlEPTB;MU[1JI5O NYnCO5dkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVQ5QThpPkKzOlE1QDl6PD;hQi=>
BHT-101 NELZeYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVqwRlFoUUN3ME2zNFAhdk1? NI\zbpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xOFg6QCd-MkO2NVQ5QTh:L3G+
RPMI-7951 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoH0TWM2OD1|NESgcm0> MkLEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUS4PVgoRjJ|NkG0PFk5RC:jPh?=
A2058 MkLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTN4MDDuUS=> MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzNEi5PEc,OjN4MUS4PVg9N2F-
SK-Hep-1 NUTBbGlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrjTWM2OD1zNEKyJI5O MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzNEi5PEc,OjN4MUS4PVg9N2F-
A673 NHOwbYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37FR2lEPTB;M{CwNUBvVQ>? MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzNEi5PEc,OjN4MUS4PVg9N2F-
DBTRG-05MG NYPq[W9NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPRTWM2OD1|MECxJI5O M2nLS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkG0PFk5Lz5{M{[xOFg6QDxxYU6=
SW-626 NGLZcJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTN|IH7N NITtdXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xOFg6QCd-MkO2NVQ5QTh:L3G+
LoVo M{PrRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\m[FdZUUN3ME20O{BvVQ>? MoDiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUS4PVgoRjJ|NkG0PFk5RC:jPh?=
MiaPaCa MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIf3dYNKSzVyPUWzJI5O MnPSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUS4PVgoRjJ|NkG0PFk5RC:jPh?=
SW-620 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTFyNDDuUS=> MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzNEi5PEc,OjN4MUS4PVg9N2F-
CAPAN-1 M3HiNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTFyNDDuUS=> MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzNEi5PEc,OjN4MUS4PVg9N2F-
SW-527 NF32V5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTF{MTDuUS=> NUfTb411RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVQ5QThpPkKzOlE1QDl6PD;hQi=>
HCT-116 NHTPeYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1X2VmlEPTB;MUK4JI5O Mk\VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUS4PVgoRjJ|NkG0PFk5RC:jPh?=
SW-480 MmHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTF4NTDuUS=> M4L3bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkG0PFk5Lz5{M{[xOFg6QDxxYU6=
HPAC MoK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Xmd2lEPTB;MUewJI5O MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzNEi5PEc,OjN4MUS4PVg9N2F-
OVCAR-5 NWm5eHBMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\SW2lEPTB;MkC4JI5O MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzNEi5PEc,OjN4MUS4PVg9N2F-
AsPc-1 NUSzOVFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHUTWM2OD1{N{Cgcm0> NVnwdYw3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVQ5QThpPkKzOlE1QDl6PD;hQi=>
A549 Mn:zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\P[ohKSzVyPUOyOkBvVQ>? M4fGdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkG0PFk5Lz5{M{[xOFg6QDxxYU6=
SNU-1 NWLjRpBoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLHcYF7UUN3ME2zOVQhdk1? Mkf4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUS4PVgoRjJ|NkG0PFk5RC:jPh?=
HOP62 NEXMdHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;5TWM2OD14N{[gcm0> MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzNEi5PEc,OjN4MUS4PVg9N2F-
H23 NFuwT2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTFyMECgcm0> NFK1NZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xOFg6QCd-MkO2NVQ5QTh:L3G+
MB-231 NW[5O|hpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVX5b3A3UUN3ME2xNFAxKG6P NI[1[4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xOFg6QCd-MkO2NVQ5QTh:L3G+
SU.86.86 Ml3vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjGZZhKSzVyPUGwNFEhdk1? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzNEi5PEc,OjN4MUS4PVg9N2F-
CFPAC-1 NFHRXXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLQO5pxUUN3ME2xNFAyKG6P NUnseI1HRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVQ5QThpPkKzOlE1QDl6PD;hQi=>
A427 NITaWFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTF2M{Ogcm0> MmDDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUS4PVgoRjJ|NkG0PFk5RC:jPh?=
MDAH-2774 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTCTWM2OD1{NkW3JI5O NUXlZ3FbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVQ5QThpPkKzOlE1QDl6PD;hQi=>
NCI-H157 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDB[JRKSzVyPUOwNFAhdk1? M3fwT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkG0PFk5Lz5{M{[xOFg6QDxxYU6=
HTB-177 NH7meY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HVNWlEPTB;M{CwNEBvVQ>? Mo\RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUS4PVgoRjJ|NkG0PFk5RC:jPh?=
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HCT-8 MmLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4i4S2lEPTB;M{CwNUBvVQ>? M{\tNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkG0PFk5Lz5{M{[xOFg6QDxxYU6=
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Assay
Methods Test Index PMID
Western blot cyclin B1 / cyclin D1 / p21 pRSK / pERK / pAKT / pMEK DUSP1 / DUSP4 / DUSP6 pCRAF(S338, S289, S296, S301) Aurora B / ETS1 / ETS2 26725216
Growth inhibition assay Cell viability 30118499
Immunofluorescence TOMM20 pERK1/2 30833752 30213106
体内研究 SCH772984按耐受剂量处理移植瘤模型,诱导肿瘤衰退。SCH772984作用于抗BRAF或MEK抑制剂的模型,有效抑制MAPK信号和细胞增殖。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

  • ERK2 IMAP 酶实验:

    SCH772984作用于纯化的ERK2或ERK1,按一式两份进行8点稀释曲线。酶添加到实验板中。与化合物温育,然后加入底物肽和ATP溶液中。384孔板中每孔加入14μl稀释的酶(每组反应含0.3ng活性ERK2)。实验板轻轻震荡混合试剂,然后在室温下温育45分钟。加入60μl of IMAP 结合溶液 (IMAP珠在1X结合缓冲液中按1:2200稀释)终止反应。实验板在室温下再温育0.5小时,使磷酸肽与IMAP珠完全结合。然后在 LJL分析仪上读数。

细胞实验:

[1]

  • Cell lines: BRAF突变型或 RAS突变型肿瘤系
  • Concentrations: ~10 μM
  • Incubation Time: 5 天
  • Method:

    在96孔板中进行细胞增殖实验,细胞按每孔 4,000个的密度接种。接种24小时后,使用DMSO处理细胞,9点IC50稀释 (0.001-10 μM) ,DMSO终浓度为1%。使用ViaLight发光试剂盒5天后,测定存活力。细胞系存活力检测中,使用SCH772984处理细胞4天,然后进行CellTiterGlo发光细胞活力检测。

动物实验:

[1]

  • Animal Models: 裸鼠
  • Dosages: 12.5 mg/kg, 25 mg/kg, 50 mg/kg
  • Administration: 腹腔注射

溶解度(25°C)

体外

体内

从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+30% PEG 300+ddH2O

0.6mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 587.67
化学式

C33H33N9O2

CAS号 942183-80-4
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

技术支持

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操作手册

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常见问题及建议解决方法

问题 1:
I would like to inhibit Erk1/2 by treating the mice with the inhibitor. by what kind of administration way and at what concentration could it be done?

回答:
SCH772984 can be administrated by I.P. The dosages can be used as: 12.5 mg/kg, 25 mg/kg, 50 mg/kg. For more detail information please find the paper below: http://cancerdiscovery.aacrjournals.org/content/3/7/742.full