Retinoid Receptor

抑制剂选择性比较

特异性亚型抑制剂

Retinoid Receptor产品

所有产品 Retinoid Receptor激动剂(10) 新Retinoid Receptor产品

产品目录	产品描述	文献引用	实验数据
S1653	Tretinoin Tretinoin，是 Retinoic acid receptor (RAR) 和Retinoid X receptor (RXR)的配体，作用于急性早幼粒细胞白血病（APL）细胞，诱导粒细胞分化和凋亡。	Cell, 2018, 175(5):1244-1258 Cell Chem Biol, 2017, 24(7):858-869	HL60 differentiation measured by expression of CD11b (flow cytometry) after a single dose exposure to HH1 or MC180295 for 4 days. 1 mM ATRA and high concentrations of DMSO (1.25%) were used as positive controls.
S2098	Bexarotene Bexarotene 是一种维甲酸，特定选择性作用于维甲酸X受体，用作口服的抗肿瘤药，治疗皮肤T细胞淋巴瘤。	J Neuroinflammation, 2019, 16(1):47 Eur J Pharm Sci, 2019, 136:104945 Neurol Res, 2018, 40(8):702-708	Bexarotene inhibited microglia activation after SAH. Left, Representative immunofluorescent images of Iba1 (red) and DAPI (blue) in basal cortex at 24 h after SAH (N = 4/group, mean ± SD). Scale bar, 30 μm. Right, quantification of Iba1 positive cells per mm2. ***p < 0.001 compared with the Sham group, ###p < 0.001 compared with the SAH + vehicle group.
S1276	Adapalene Adapalene是一类RAR和RXR双重的激动剂，主要用于治疗痤疮。
S1368	Acitretin Acitretin 是一种二代维甲酸，用于治疗牛皮癣。	Antimicrob Agents Chemother, 2017, 61(11). pii: e01368-17 Saudi Pharm J, 2017, 25(4):620-624	Acitretin does not induce HIV reactivation in J-lat and ACH-2 cells. (a, b) HIV reactivation induced by acid retinoic (AR) derivative acitretin (25 – 1 μM) in J-Lat cells clone 8.4 (a) and 9.2(b). HDAC inhibitors (HDCAi) panobinostat (PNB, 0.16μM) and vorinostat (VOR, 4 – 0.16 μM) were used as controls. Reactivation was determined by the quantification of GFP+ cells (%) after culturing J-Lat with HDACi and acitretin for 24h. (c, d) HIV reactivation induced by acitretin and HDACi in ACH-2 cells. Reactivation was determined after 48h of incubation by quantification of CAp24 (c) and HIV RNA copy number (d) in the supernatant. Values represent mean±SD of at least three independent experiments performed in triplicate. UN, untreated. P < 0.05; P < 0.01; **P < 0.001.
S1569	Tazarotene Tazarotene是RAR激动剂tazarotenic acid的前药，用于治疗牛皮癣，粉刺以及晒伤。	J Clin Invest, 2013, 123(9):3941-51
S2933^New	AM580 AM580是视黄酸核受体（RAR）激动剂，对RARα, RARβ和RARγ的Kd值分别为8 nM, 131 nM 和450 nM。
S6132^New	All trans-Retinal All trans-Retinal是维甲酸循环中的组分之一，在体内通过视黄醛脱氢酶转化为视黄酸。Retinoic acid是RAR和RXR的配体。All trans-retinal是一种有效的光敏剂。
S4627	TTNPB (Arotinoid Acid) TTNPB (Arotinoid Acid)是有效的RAR激动剂, 抑制与[³H]tRA结合,作用于人类RARα, β, 和 γ, IC50分别为5.1 nM, 4.5 nM,和 9.3 nM。	J Biol Chem, 2017, 10.1074/jbc.M117.812537
S4260	Tamibarotene Tamibarotene是特异性的RAR-alpha/beta激动剂, 用于治疗全反式视黄酸耐受的急性白血病。
S4699	Etretinate Etretinate是可口服的芳香类维生素a酸，在牛皮鲜和其他皮肤综合症的治疗中十分有效。它能够激活视黄素受体，诱导细胞分化、抑制细胞增殖以及抑制组织浸润。

产品目录	产品描述	文献引用	实验数据
S1653	Tretinoin Tretinoin，是 Retinoic acid receptor (RAR) 和Retinoid X receptor (RXR)的配体，作用于急性早幼粒细胞白血病（APL）细胞，诱导粒细胞分化和凋亡。	Cell, 2018, 175(5):1244-1258 Cell Chem Biol, 2017, 24(7):858-869	HL60 differentiation measured by expression of CD11b (flow cytometry) after a single dose exposure to HH1 or MC180295 for 4 days. 1 mM ATRA and high concentrations of DMSO (1.25%) were used as positive controls.
S2098	Bexarotene Bexarotene 是一种维甲酸，特定选择性作用于维甲酸X受体，用作口服的抗肿瘤药，治疗皮肤T细胞淋巴瘤。	J Neuroinflammation, 2019, 16(1):47 Eur J Pharm Sci, 2019, 136:104945 Neurol Res, 2018, 40(8):702-708	Bexarotene inhibited microglia activation after SAH. Left, Representative immunofluorescent images of Iba1 (red) and DAPI (blue) in basal cortex at 24 h after SAH (N = 4/group, mean ± SD). Scale bar, 30 μm. Right, quantification of Iba1 positive cells per mm2. ***p < 0.001 compared with the Sham group, ###p < 0.001 compared with the SAH + vehicle group.
S1276	Adapalene Adapalene是一类RAR和RXR双重的激动剂，主要用于治疗痤疮。
S1368	Acitretin Acitretin 是一种二代维甲酸，用于治疗牛皮癣。	Antimicrob Agents Chemother, 2017, 61(11). pii: e01368-17 Saudi Pharm J, 2017, 25(4):620-624	Acitretin does not induce HIV reactivation in J-lat and ACH-2 cells. (a, b) HIV reactivation induced by acid retinoic (AR) derivative acitretin (25 – 1 μM) in J-Lat cells clone 8.4 (a) and 9.2(b). HDAC inhibitors (HDCAi) panobinostat (PNB, 0.16μM) and vorinostat (VOR, 4 – 0.16 μM) were used as controls. Reactivation was determined by the quantification of GFP+ cells (%) after culturing J-Lat with HDACi and acitretin for 24h. (c, d) HIV reactivation induced by acitretin and HDACi in ACH-2 cells. Reactivation was determined after 48h of incubation by quantification of CAp24 (c) and HIV RNA copy number (d) in the supernatant. Values represent mean±SD of at least three independent experiments performed in triplicate. UN, untreated. P < 0.05; P < 0.01; **P < 0.001.
S1569	Tazarotene Tazarotene是RAR激动剂tazarotenic acid的前药，用于治疗牛皮癣，粉刺以及晒伤。	J Clin Invest, 2013, 123(9):3941-51
S2933^New	AM580 AM580是视黄酸核受体（RAR）激动剂，对RARα, RARβ和RARγ的Kd值分别为8 nM, 131 nM 和450 nM。
S6132^New	All trans-Retinal All trans-Retinal是维甲酸循环中的组分之一，在体内通过视黄醛脱氢酶转化为视黄酸。Retinoic acid是RAR和RXR的配体。All trans-retinal是一种有效的光敏剂。
S4627	TTNPB (Arotinoid Acid) TTNPB (Arotinoid Acid)是有效的RAR激动剂, 抑制与[³H]tRA结合,作用于人类RARα, β, 和 γ, IC50分别为5.1 nM, 4.5 nM,和 9.3 nM。	J Biol Chem, 2017, 10.1074/jbc.M117.812537
S4260	Tamibarotene Tamibarotene是特异性的RAR-alpha/beta激动剂, 用于治疗全反式视黄酸耐受的急性白血病。
S4699	Etretinate Etretinate是可口服的芳香类维生素a酸，在牛皮鲜和其他皮肤综合症的治疗中十分有效。它能够激活视黄素受体，诱导细胞分化、抑制细胞增殖以及抑制组织浸润。