Retinoid Receptor
抑制剂选择性比较
特异性亚型抑制剂
Retinoid Receptor产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S5233 |
FenretinideFenretinide (4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016) is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). |
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S6605 |
AR7AR7是视黄酸受体α(RARα)拮抗剂。 |
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S1653 |
Tretinoin (Retinoic acid)Tretinoin (Retinoic acid, All-trans Retinoic Acid, ATRA),是 Retinoic acid receptor (RAR) 和Retinoid X receptor (RXR)的配体,作用于急性早幼粒细胞白血病(APL)细胞,诱导粒细胞分化和凋亡。 |
![]() ![]() HL60 differentiation measured by expression of CD11b (flow cytometry) after a single dose exposure to HH1 or MC180295 for 4 days. 1 mM ATRA and high concentrations of DMSO (1.25%) were used as positive controls.
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S2098 |
BexaroteneBexarotene (Targretin, LGD1069) 是一种维甲酸,特定选择性作用于维甲酸X受体,用作口服的抗肿瘤药,治疗皮肤T细胞淋巴瘤。 |
![]() ![]() Bexarotene inhibited microglia activation after SAH. Left, Representative immunofluorescent images of Iba1 (red) and DAPI (blue) in basal cortex at 24 h after SAH (N = 4/group, mean ± SD). Scale bar, 30 μm. Right, quantification of Iba1 positive cells per mm2. ***p < 0.001 compared with the Sham group, ###p < 0.001 compared with the SAH + vehicle group.
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S1276 |
AdapaleneAdapalene (CD-271是一类RAR和RXR双重的激动剂,主要用于治疗痤疮。 |
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S1368 |
AcitretinAcitretin (Etretin, RO 10-1670) 是一种二代维甲酸,用于治疗牛皮癣。 |
![]() ![]() Acitretin does not induce HIV reactivation in J-lat and ACH-2 cells. (a, b) HIV reactivation induced by acid retinoic (AR) derivative acitretin (25 – 1 μM) in J-Lat cells clone 8.4 (a) and 9.2(b). HDAC inhibitors (HDCAi) panobinostat (PNB, 0.16μM) and vorinostat (VOR, 4 – 0.16 μM) were used as controls. Reactivation was determined by the quantification of GFP+ cells (%) after culturing J-Lat with HDACi and acitretin for 24h. (c, d) HIV reactivation induced by acitretin and HDACi in ACH-2 cells. Reactivation was determined after 48h of incubation by quantification of CAp24 (c) and HIV RNA copy number (d) in the supernatant. Values represent mean±SD of at least three independent experiments performed in triplicate. UN, untreated. *P < 0.05; **P < 0.01; ***P < 0.001.
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S1569 |
TazaroteneTazarotene (AGN190168)是RAR激动剂tazarotenic acid的前药,用于治疗牛皮癣,粉刺以及晒伤。 |
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S4627 |
TTNPB (Arotinoid Acid)TTNPB (Arotinoid Acid, Ro 13-7410, AGN-191183)是有效的RAR激动剂, 抑制与[3H]tRA结合,作用于人类RARα, β, 和 γ, IC50分别为5.1 nM, 4.5 nM,和 9.3 nM。 |
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S4260 |
TamibaroteneTamibarotene是特异性的RAR-alpha/beta激动剂, 用于治疗全反式视黄酸耐受的急性白血病。 |
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S6132 |
All trans-RetinalAll trans-Retinal (Retinaldehyde, Vitamin A aldehyde, Retinene)是维甲酸循环中的组分之一,在体内通过视黄醛脱氢酶转化为视黄酸。Retinoic acid是RAR和RXR的配体。All trans-retinal是一种有效的光敏剂。 |
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S2933 |
AM580AM580是视黄酸核受体(RAR)激动剂,对RARα, RARβ和RARγ的Kd值分别为8 nM, 131 nM 和450 nM。 |
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S4699 |
EtretinateEtretinate (Tegison, Ethyl etrinoate, Retinoid, Etretinato)是可口服的芳香类维生素a酸,在牛皮鲜和其他皮肤综合症的治疗中十分有效。它能够激活视黄素受体,诱导细胞分化、抑制细胞增殖以及抑制组织浸润。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S5233 |
FenretinideFenretinide (4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016) is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S6605 |
AR7AR7是视黄酸受体α(RARα)拮抗剂。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1653 |
Tretinoin (Retinoic acid)Tretinoin (Retinoic acid, All-trans Retinoic Acid, ATRA),是 Retinoic acid receptor (RAR) 和Retinoid X receptor (RXR)的配体,作用于急性早幼粒细胞白血病(APL)细胞,诱导粒细胞分化和凋亡。 |
![]() ![]() HL60 differentiation measured by expression of CD11b (flow cytometry) after a single dose exposure to HH1 or MC180295 for 4 days. 1 mM ATRA and high concentrations of DMSO (1.25%) were used as positive controls.
|
|
S2098 |
BexaroteneBexarotene (Targretin, LGD1069) 是一种维甲酸,特定选择性作用于维甲酸X受体,用作口服的抗肿瘤药,治疗皮肤T细胞淋巴瘤。 |
![]() ![]() Bexarotene inhibited microglia activation after SAH. Left, Representative immunofluorescent images of Iba1 (red) and DAPI (blue) in basal cortex at 24 h after SAH (N = 4/group, mean ± SD). Scale bar, 30 μm. Right, quantification of Iba1 positive cells per mm2. ***p < 0.001 compared with the Sham group, ###p < 0.001 compared with the SAH + vehicle group.
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|
S1276 |
AdapaleneAdapalene (CD-271是一类RAR和RXR双重的激动剂,主要用于治疗痤疮。 |
||
S1368 |
AcitretinAcitretin (Etretin, RO 10-1670) 是一种二代维甲酸,用于治疗牛皮癣。 |
![]() ![]() Acitretin does not induce HIV reactivation in J-lat and ACH-2 cells. (a, b) HIV reactivation induced by acid retinoic (AR) derivative acitretin (25 – 1 μM) in J-Lat cells clone 8.4 (a) and 9.2(b). HDAC inhibitors (HDCAi) panobinostat (PNB, 0.16μM) and vorinostat (VOR, 4 – 0.16 μM) were used as controls. Reactivation was determined by the quantification of GFP+ cells (%) after culturing J-Lat with HDACi and acitretin for 24h. (c, d) HIV reactivation induced by acitretin and HDACi in ACH-2 cells. Reactivation was determined after 48h of incubation by quantification of CAp24 (c) and HIV RNA copy number (d) in the supernatant. Values represent mean±SD of at least three independent experiments performed in triplicate. UN, untreated. *P < 0.05; **P < 0.01; ***P < 0.001.
|
|
S1569 |
TazaroteneTazarotene (AGN190168)是RAR激动剂tazarotenic acid的前药,用于治疗牛皮癣,粉刺以及晒伤。 |
||
S4627 |
TTNPB (Arotinoid Acid)TTNPB (Arotinoid Acid, Ro 13-7410, AGN-191183)是有效的RAR激动剂, 抑制与[3H]tRA结合,作用于人类RARα, β, 和 γ, IC50分别为5.1 nM, 4.5 nM,和 9.3 nM。 |
||
S4260 |
TamibaroteneTamibarotene是特异性的RAR-alpha/beta激动剂, 用于治疗全反式视黄酸耐受的急性白血病。 |
||
S6132 |
All trans-RetinalAll trans-Retinal (Retinaldehyde, Vitamin A aldehyde, Retinene)是维甲酸循环中的组分之一,在体内通过视黄醛脱氢酶转化为视黄酸。Retinoic acid是RAR和RXR的配体。All trans-retinal是一种有效的光敏剂。 |
||
S2933 |
AM580AM580是视黄酸核受体(RAR)激动剂,对RARα, RARβ和RARγ的Kd值分别为8 nM, 131 nM 和450 nM。 |
||
S4699 |
EtretinateEtretinate (Tegison, Ethyl etrinoate, Retinoid, Etretinato)是可口服的芳香类维生素a酸,在牛皮鲜和其他皮肤综合症的治疗中十分有效。它能够激活视黄素受体,诱导细胞分化、抑制细胞增殖以及抑制组织浸润。 |