IDO 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S8629 Linrodostat (BMS-986205)

Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays.

Selective IDO1, IC50: 1.7 nM
S8557 IDO inhibitor 1

IDO inhibitor 1 is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) with IC50 of 3 nM.

Selective IDO, IC50: 3 nM
S8957 Navoximod

Navoximod is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) pathway with Ki of 7 nM and EC50 of 75 nM.

Selective IDO, EC50: 75 nM; IDO, Ki: 7 nM
S7910 Epacadostat (INCB024360)

Epacadostat (INCB024360)是一种有效的选择性吲哚胺 2,3-双加氧酶(IDO1)抑制剂,IC50为 10 nM。它对IDO1的选择性高于其他相关酶如IDO2或TDO。

Selective IDO1, IC50: 10 nM
S7111 IDO-IN-2

NLG919是一种有效的IDO (indoleamine-(2,3)-dioxygenase)通路抑制剂,无细胞试验中Ki/EC50为 7 nM/75 nM。Phase 1。

Selective IDO1, IC50: 38 nM
S6728 IDO-IN-1

IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 59 nM.

Selective IDO, IC50: 59 nM
S7587 INCB024360 analogue

INCB024360 analogue是一个强效的竞争性IDO1 (indoleamine-(2,3)-dioxygenase)抑制剂,其IC50为67 nM。Phase 2。

Selective IDO1, IC50: 67 nM
S8657 PF-06840003

PF-06840003 (EOS200271) is a highly selective orally bioavailable IDO-1 inhibitor. Although it has moderate hIDO1 enzyme inhibition (IC50 0.41 μM), it is a highly efficient compound (LE 0.53, LipE 5.1), driven by its tight packing within the enzyme, as well as the high density of hydrogen bonds it forms with hIDO-1 despite its small size.

Selective mIDO-1, IC50: 1.5 μM; dIDO-1, IC50: 0.59 μM; hIDO-1, IC50: 0.41 μM
S5249 Coptisine chloride

Coptisine (Q-100696, NSC-119754) is an isoquinoline alkaloid isolated from Coptidis Rhizoma with anti-diabetic, antimicrobial, antiviral, anti-hepatoma, and anti-leukemia effects. Coptisine chloride is an efficient uncompetitive IDO inhibitor with IC50 value of 6.3 μM and Ki value of 5.8 μM.

Selective IDO, Ki: 5.8 μM; IDO, IC50: 6.3 μM
S8919 LY-3381916

LY-3381916 is a potent, selective and brain penetrated IDO1 inhibitor.

S7756 Indoximod (NLG-8189)

Indoximod (NLG-8189),一个甲基化的色氨酸,作为 IDO (吲哚胺-(2,3)-双加氧酶) 通路抑制剂,并且能够逆转IDO介导的免疫抑制。Phase 2。