NMDA receptor 选择性拮抗剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S5032 Mephenesin

Mephenesin (Decontractyl, Cresoxydiol, Memphenesin, Mephedan) is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist.

Selective
S5302 6-Methoxy-2-naphthoic acid

6-Methoxy-2-naphthoic acid (6-Methoxy-2-naphthalenecarboxylic acid) is an modulator of NMDAR.

Selective
S5287 Tiletamine Hydrochloride

Tiletamine is a lipophilc and potent vetrinary anesthetic. It is also a NMDA receptor antagonist.

Selective
S4957 Linalool

Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.

Selective
S3624 Quinolinic acid

Quinolinic Acid (pyridine-2,3-dicarboxylic acid, QUIN), a neuroactive metabolite of the kynurenine pathway, is an agonist of N-methyl-D-aspartate (NMDA) receptor.

Selective
S2857 (-)-Dizocilpine (MK 801) Maleate

MK-801 (Dizocilpine)是一种有效的N-methyl-D-aspartate(NMDA)受体拮抗剂,Ki为30.5 nM。

Selective NMDA receptor, Ki: 30.5 nM
S2876 (+)-Dizocilpine (MK 801) Maleate

(+)-MK 801 Maleate作用于大鼠脑组织膜,是一种有效的,选择性的,非竞争性NMDA受体拮抗剂,Kd为37.2 nM。

Selective NMDA receptor, Kd: 37.2 nM
S4091 Ifenprodil Tartrate

Ifenprodil是一种非典型非竞争性的NMDA受体拮抗剂,在新生大鼠前脑中,高亲和力结合于NMDA受体,IC50为0.3 μM。

Selective NMDA Receptor, IC50: 0.3 μM
S4023 Procaine HCl

Procaine HCl是一种钠离子通道的,NMDA受体以及乙酰胆碱受体抑制剂, IC50分别为60 μM, 0.296 mM何45.5 μM,也是一种,5-HT3抑制剂,KD为1.7 μM。

Selective NMDA receptor, IC50: 0.296 mM
S1330 Felbamate

Felbamate 是一种抗惊厥药,用于治疗癫痫。是NMDAR拮抗剂。

Selective NMDAR, IC50: 1.8 mM
S4719 Kynurenic acid

Kynurenic acid是色氨酸通过犬尿氨酸途径代谢的天然代谢物,是一种广谱的兴奋性氨基酸拮抗剂。它是NMDAR, kainate receptor和AMPA receptor的拮抗剂。

Selective
S3203 D-Alanine

D-alanine (Ala, (R)-Alanine, Ba 2776, D-α-Alanine, NSC 158286) is an endogenous co-agonist at the glycine site of the N-methyl-d-aspartate (NMDA) receptor.

Selective
S6907 Rapastinel (GLYX-13)

Rapastinel (GLYX-13, BV-102, TPPT-amide) is a partial agonist of N-methyl-D-aspartate receptor (NMDAR) that targeting a glycine site. Rapastinel has long-lasting antidepressant effects.

Selective
S3653 Spermidine trihydrochloride

Spermidine (4-Azaoctamethylenediamine), a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).

Selective
S7072 NMDA (N-Methyl-D-aspartic acid)

NMDA (N-Methyl-D-aspartic acid)是一种特异性NMDA受体激动剂,通常作为受体,模拟神经递质谷氨酸的活性。Phase 4。

Selective
S6731 Eliprodil (SL-820715)

Eliprodil (SL-820715) is a non-competitive NR2B-selective NMDA antagonist with IC50 value of 1 μM and is less potent for NR2A- and NR2C-containing receptors with IC50 > 100 μM.

Selective
s4702 Sarcosine

Sarcosine是GlyT1的竞争性抑制剂以及天冬氨酸受体(NMDAR)的协同激动剂。

Selective
S1614 Riluzole (PK 26124)

Riluzole是谷氨酸盐释放抑制剂,具有神经保护、抗癫痫、抗焦虑以及麻醉作用。

Selective