P450 选择性抑制剂 | 化学产品

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S9257 Acetylshikonin

Acetylshikonin is a biologically active compound with anti-cancer and anti-inflammatory activity, which is isolated from the roots of Lithospermum erythrorhizoma. It is a novel general P450 inhibitor with IC50 values of 1.4-4.0 μM for all tested P450s.

Selective
S2067 Ozagrel HCl

Ozagrel HCl是选择性血栓素A2合成酶抑制剂,其在兔子血小板中IC50为11 nM, 用作改善手术后脑血管收缩,以及伴随的脑梗塞。

Selective thromboxane A2 synthetase, IC50: 11 nM
S2496 Ozagrel

Ozagrel是一种有效的,选择性的血栓素A2合成酶抑制剂,IC50为4 nM。

Selective Thromboxane A2 synthetase , IC50: 11 nM
S1195 TAK-700 (Orteronel)

TAK-700 (Orteronel)是一种有效的,高度选择性的,人17,20-lyase抑制剂,IC50为38 nM,比作用于其他CYPs(例如11-羟化酶和CYP3A4)选择性高1000倍以上。Phase 3。

Selective 17,20-lyase (Rat), IC50: 54 nM; 17,20-lyase (Human), IC50: 38 nM
S1353 Ketoconazole (R 41400)

Ketoconazole能抑制cyclosporine oxidase(环孢素氧化酶)testosterone 6 beta-hydroxylase(睾丸素6β-羟化酶)IC50分别为0.19 mM和0.22 mM。

Selective Cyclosporine oxidase, IC50: 0.19 mM
S1442 Voriconazole (UK-109496)

Voriconazole是一种三唑类抗真菌药物,用于治疗严重的侵入性真菌感染。

Selective
S6790 Ellipticine hydrochloride

Ellipticine Hydrochloride (NSC 71795, PZE) is a potent inhibitor of DNA topoisomerase II and forms covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine Hydrochloride is a natural product isolated from the Australian evergreen tree of the Apocynaceae family with antineoplastic activity.

Selective
S1331 Fluconazole (UK 49858)

Fluconazole是一种羊毛甾醇14 alpha去甲基化酶 抑制剂,抑制了麦角固醇的形成,用于治疗和预防浅表性和全身性真菌感染。

Selective
S6886 1-Aminobenzotriazole

1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).

Selective
S2401 Sodium Danshensu

Sodium Danshensu是丹参素的单钠盐,是从Salvia miltiorrhiza Bge中分离的天然酚酸,是咖啡酸衍生物。

Selective
S2329 Naringin

Naringin 是一种黄酮苷,是葡萄柚中的主要的类黄酮,具有柚子汁的苦味。具有抗氧化,降血脂,抗肿瘤活性,并且对cytochrome P450有抑制作用。

Selective
S3273 Hypericin

Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).

Selective