Topo I 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S3898 Hydroxy Camptothecine

Hydroxy Camptothecine (10-Hydroxycamptothecin, Hydroxycamptothecine) is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.

Selective
S0093 Genz-644282

Genz-644282 is a non-camptothecin topoisomerase I (Topo I) inhibitor which can used in cancer research.

Selective Topo I, IC50: 1.2 nM
S1231 Topotecan (NSC609699) HCl

Topotecan HCl是一种拓扑异构酶I抑制剂,作用于MCF-7 Luc细胞和DU-145 Luc细胞,无细胞试验中IC50分别为13 nM和2 nM。

Selective Topo I (MCF-7 Luc cells), IC50: 13 nM; Topo I (DU-145 Luc cells), IC50: 2 nM
S1288 Camptothecin (NSC-100880)

Camptothecin是一种特异性的DNA拓扑异构酶I (Topo I)抑制剂,IC50为0.68 μM。Phase 2。

Selective Topo I, IC50: 0.68 μM
S3603 Betulinic acid

Betulinic acid是一种天然的五环三萜类化合物,具有抗病毒,抗疟药,抗发炎和抗肿瘤的特性。Phase 1/2

Selective Eukaryotic topoisomerase I, IC50: 5 μM
S6631 Belotecan (CKD-602) hydrochloride

Belotecan (CKD-602) is a potent DNA topoisomerase I inhibitor that exerts a clinical anticancer effect on various types of tumor.

Selective
S4908 SN-38

SN-38是CPT-11的一种活性代谢物,抑制DNA topoisomerase I,DNA合成,并造成频繁的DNA单链断裂。

Selective
S2423 (S)-10-Hydroxycamptothecin

(S)-10-Hydroxycamptothecin是DNA拓扑异构酶I抑制剂,具有有效的抗肿瘤活性。

Selective
S7261 Beta-Lapachone

Beta-Lapachone是一种选择性的DNA topoisomerase I(DNA拓扑异构酶I)抑制剂,对DNA拓扑异构酶II或连接酶无抑制作用。Phase 2。

Selective
S5111 7-Ethylcamptothecin

7-Ethyl Camptothecin is an anti-cancer chemical that exhibits a strong activity against various murine tumors through Topo I (topoisomerase) inhibition.

Selective
S6747 SW-044248

SW-044248 is a non-canonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells.

Selective
S2653 9-amino-CPT (9-Aminocamptothecin)

9-amino-CPT (9-Aminocamptothecin, 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin) is a Topoisomerase I inhibitor with potent anticancer activities. 9-amino-CPT (9-Aminocamptothecin) is an active, water-insoluble derivative of camptothecin.

Selective
S2288 Rubitecan

Rubitecan (9-NC, 9-Nitro-camptothecin, Partaject Orathecin, Partaject rubitecan, RFS 2000) is a topoisomerase I inhibitor extracted from the bark and leaves of the Camptotheca acuminata tree, which is native to China. Rubitecan is an oral camptothecin with antitumour activity.

Selective
S9321 Topotecan

Topotecan is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.

Selective
S5026 Irinotecan hydrochloride

Irinotecan (CPT-11, (+)-Irinotecan) hydrochloride is an inhibitor of Topoisomerase I (Topo I) that exhibits cytotoxicity in LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.

Selective
S1198 Irinotecan (CPT-11)

Irinotecan是一种Topoisomerase I抑制剂,作用于LoVo细胞和HT-29细胞,IC50分别为15.8 μM和5.17 μM。

Selective
S2217 Irinotecan (CPT-11) HCl Trihydrate

Irinotecan HCl Trihydrate通过抑制Topoisomerase 1(拓扑异构酶1)而防止DNA解链。

Selective
S2271 Berberine chloride (NSC 646666)

Berberine chloride是异喹啉类生物碱的季铵盐。

Pan
S1327 Ellagic acid

Ellagic acid具有抗增殖和抗氧化性能。

Pan