Ferroptosis

抑制剂选择性比较

Ferroptosis产品

所有产品 Ferroptosis抑制剂(8) Ferroptosis激活剂(10) Ferroptosis调节剂(2)

目录号	产品描述	文献引用	实验数据
S1077	SB202190 (FHPI) SB202190 (FHPI)是一种有效的p38 MAPK抑制剂，靶向作用于p38α/β，无细胞试验中IC50为50 nM/100 nM，有时用于代替SB 203580研究其在体内对SAPK2a/p38的潜在作用。SB202190 可通过诱导自噬和血红素氧化酶1来抑制内皮细胞的凋亡。SB202190可显著抑制Erastin依赖的铁死亡ferroptosis。	Redox Biol, 2020, 28:101445 Cells, 2020, 13;9(5) pii: E1209 Cells, 2020, 28;9(4) pii: E822	C, Jurkat cells with SB202190 at 1, 5, and 10 μM were tested, and a decreased SRP72 expression was found when using at 10 μM (lanes 8 and 9). D, results were analyzed and RUA illustrated, finding significant results at 10 μM at 240 versus 0 and 120 versus 0 min (p<0.05).
S0788^New	ML 210 ML-210 是一种选择性的 glutathione peroxidase 4 (GPX4) 的共价抑制剂，其EC50值为0.04 μM，可诱导铁死亡。ML-210 可以选择性地杀死诱导表达突变型 RAS 的细胞，并具有抗癌活性。
S2505	Rosiglitazone maleate Rosiglitazone maleate 是一种噻唑烷二酮类抗高血糖药，是PPARγ的高亲和、选择性的激动剂，IC50为42 nM。Rosiglitazone maleate 也能调节 TRP channels并诱导自噬。Rosiglitazone 可预防铁死亡。	Virol Sin, 2019, 34(6):648-661 Drugs R D, 2017, 10.1007/s40268-016-0166-4 J Inflamm (Lond), 2016, 13:19	Total and phosphorylated Akt were detected by western blot in protein lysates of liver, inguinal WAT and gastrocnemius muscle from mice that were treated with an insulin bolus after an overnight fast.
S2556	Rosiglitazone Rosiglitazone 是有效的降糖药，也是有效的噻唑烷二酮类胰岛素增敏剂，在大鼠，3T3-L1和人体脂肪细胞中IC50分别为12，4和9 nM。Rosiglitazone是PPAR-gamma的配体，对PPAR-alpha没有结合力。Rosiglitazone 可调控 TRP channels 并诱导自噬。Rosiglitazone可阻止铁死亡。	Nat Commun, 2020, 11(1):71 Cancer Cell Int, 2020, 19;20:58 Cancer Chemother Pharmacol, 2020, 85(2):273-284
S1623	Acetylcysteine(N-acetylcysteine) Acetylcysteine(N-acetyl-l-cysteine)是ROS抑制剂，拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂，主要用作祛痰剂，可通过维持或恢复肝脏中谷胱甘肽的浓度来处理扑热息痛(对乙酰氨基酚过量)。Acetylcysteine(N-acetyl-l-cysteine) 通过抑制IκB kinases抑制TNF诱导的NF-κB活化。Acetylcysteine(N-acetyl-l-cysteine) 通过线粒体依赖性途径诱导凋亡并抑制铁死亡和病毒复制。现配现用。	Cell Death Differ, 2020, 10.1038/s41418-020-0496-1 J Hazard Mater, 2020, 5;391:122203 Oxid Med Cell Longev, 2020, 13;2020:3145182	(C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.
S7243	Ferrostatin-1 (Fer-1) Ferrostatin-1 (Fer-1)是一种有效的选择性的ferroptosis抑制剂，EC50为60 nM。	ACS Nano, 2020, 24;14(3):3414-3425 Nat Commun, 2020, 23;11(1):433 Nat Commun, 2020, 6;11(1):1251	Indicated HCC cells were treated with sorafenib (5 µM) and erastin (10 µM) with or without cell death inhibitors (ferrostatin-1, 1 µM; liprostatin-1, 100nM; ZVAD-FMK,10 µM; necrosulfonamide, 0.5 µM) for 24 hours and cell viability was assayed (n=3, *p < 0.05 versus sorafenib or erastin treatment group).
S7699	Liproxstatin-1 Liproxstatin-1是一种有效的ferroptosis抑制剂，IC50为22 nM。	Nat Commun, 2020, 23;11(1):433 Sci Adv, 2020, 25;6(13):eaay9789 Autophagy, 2020, 18;1-13	(D) Indicated NRF2 knockdown HCC cells were treated with erastin (10 μM) and sorafenib (5 μM) with or without indicated inhibitors (ferrostatin-1, 1 μM; liproxstatin-1, 100 nM; ZVAD-FMK, 10 μM; necrostatin-1, 10 μM; necrosulfonamide, 0.5 μM) for 24 hours, and cell viability was assayed (n 5 3, *P < 0.05). Abbreviation: GAPDH, glyceraldehyde 3-phosphate dehydrogenase.
S8792	UAMC-3203 UAMC-3203是ferroptosis抑制剂，在IMR-32神经母细胞瘤细胞中IC50为10 nM。
S1040	Sorafenib Tosylate Sorafenib Tosylate 是Raf-1和B-Raf的多重激酶抑制剂，无细胞试验中IC50分别为6 nM和22 nM。Sorafenib 还可抑制VEGFR-2、VEGFR-3、PDGFR-β、Flt-3和c-KIT，对应的IC50值分别为90 nM、20 nM、57 nM、59 nM和68 nM。Sorafenib Tosylate 可诱导autophagy、apoptosis并激活ferroptosis，并具有抗肿瘤活性。	Elife, 2020, 22;9:e51358 J Exp Clin Cancer Res, 2020, 39(1):24 Cancers (Basel), 2020, 27;12(5)pii: E1087	Inhibition of breast cancer cell growth using sorafenib. MCF-7 breast cancer cells were treated with increasing concentrations of sorafenib for 5 days. Cell number was measured using a colorimetric growth assay (crystal violet stain) and expressed relative to DMSO treated control cells.
S1166	Cisplatin Cisplatin 是一种无机铂络合物，在肿瘤细胞中能够通过形成DNA加合物抑制 DNA synthesis。Cisplatin 可激活ferroptosis并诱导autophagy。建议现配现用。	Cancer Cell, 2020, 37(2):157-167 Cancer Cell, 2020, 37(3):371-386 Cancer Cell, 2020, 13;37(1):104-122e12	Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05.
S1007	Roxadustat (FG-4592) Roxadustat (FG-4592)在无细胞试验中是一种HIF-α脯氨酰羟化酶抑制剂，并能稳定HIF-2，同时诱导EPO产生。Roxadustat可加强RSL3诱导的 ferroptosis。Phase 3。	J Med Chem, 2020, 31 J Exp Clin Cancer Res, 2020, 39(1):24 FASEB J, 2020, 34(2):2344-2358	Immunoblots showing dose-dependent HIF-1α stabilization in U2OS, HeLa and Hep3b (and HIF-2α) cells after 6 hours treatment with FG-4592.
S2111	Lapatinib Lapatinib，以 Lapatinib Ditosylate的形式使用，是一种有效的EGFR和ErbB2抑制剂，在无细胞试验中IC50分别为10.2和9.8 nM。Lapatinib 可诱导 ferroptosis 和细胞自噬。	Acta Neuropathol, 2020, 17 Nat Commun, 2020, 11(1):385 Nat Commun, 2020, 25;11(1):1556	Aberrantly activated PI3K/AKT pathway mediates lapatinib resistance in SK-BR-3-LR cells. (A and B) After drug treatment, phosphorylation of HER2, EGFR, AKT, and ERK1/2 was determined by Western blotting using speciﬁc antibodies.
S1792	Simvastatin Simvastatin 是一种HMG-CoA reductase竞争性抑制剂，无细胞试验中K_i为0.1-0.2 nM。Simvastatin可诱导铁死亡、线粒体自噬、细胞自噬和凋亡。	Aging (Albany NY), 2020, 44187 Vaccines (Basel), 2020, 6;8(1):72 Sci Rep, 2020, 10(1):931	Statin-Related Inhibition of Dehydroepiandrosterone Sulfate (DHEAS) Uptake by SLCO2B1 in Prostate Cancer (PC) Cells. B, Uptake of DHEAS in PC cells with 2.5 µM DHEAS and different concentrations of statins when incubated for 60 minutes. Statistical analysis was performed by comparing each condition with the DHEAS 2.5 µM and no statin state except when indicated. C, Uptake of DHEAS in PC cells before (scrambled short hairpin RNA) and after (short hairpin RNA 2B1) SLCO2B1 is knocked down when incubated with 2.5 μM DHEAS and 100 μM atorvastatin for 10 and 60 minutes. Statistical analysis was performed by comparing each condition with scrambled short hairpin RNA after 10 minutes with DHEAS except when indicated. P = .02 for the comparison between scrambled short hairpin RNA with 10 vs 60 minutes of DHEAS incubation for LNCaP and .01 for 22RV1. Other P values are indicated in the figure. Bars indicate means and error bars indicate standard deviation.
S7397	Sorafenib Sorafenib 是Raf-1和B-Raf的多重激酶抑制剂，无细胞试验中IC50分别为6 nM和22 nM。Sorafenib 还可抑制VEGFR-2、VEGFR-3、PDGFR-β、Flt-3和c-KIT，对应的IC50值分别为90 nM、20 nM、57 nM、59 nM和68 nM。Sorafenib 可诱导autophagy、apoptosis并激活ferroptosis，Sorafenib 具有抗肿瘤活性。	Cell Metab, 2020, 5;31(5):892-908 e11 Autophagy, 2020, 10.1080/15548627.2019.1709762 Cell Rep, 2020, 31(2):107514	Involvement of EV linc-VLDLR in tumor cell responses to chemotherapy. Cells were incubated with sorafenib, camptothecin, or doxorubicin. EVs were obtained after 24 hours, and qRT-PCR was performed for linc-VLDLR. The bars represent the mean ?SEM of the increase in cell viability from 3 independent studies. *, P < 0.05.
S7242	Erastin Erastin是一种ferroptosis激活剂，通过作用于线粒体VDAC而起作用，选择性作用于携带致癌基因RAS的肿瘤细胞。	Nat Chem Biol, 2020, 6 Nat Commun, 2020, 23;11(1):433 Sci Adv, 2020, 25;6(13):eaay9789	Western blot analysis indicated protein expression in PDAC cells following treatment with erastin (2.5-40 μmol/L) for 24 hours (n=3, * P < 0.05 vs. untreated group)
S8254	FIN56 FIN56是ferroptosis的特异性诱导剂。	Dev Cell, 2019, 10.1016/j.devcel.2019.10.007 Biochem Biophys Res Commun, 2019, 510(2):278-283 Curr Biol, 2018, 28(15):2388-2399
S8155	RSL3 RSL3是一种ferroptosis的激活剂，不依赖于VDAC，对携带致瘤性RAS的肿瘤细胞具有选择性。它结合并使GPX4失活，介导GPX4所调节的铁死亡。	Nat Cell Biol, 2020, 22(2):225-234 Autophagy, 2020, 18;1-13 Theranostics, 2020, 6;10(11):5107-5119	(D) Representative western blot and (E) densitometry showing protein levels of HO-1 in HO-1+/+ PTCs treated with RSL3 over time. Data shown represent the Mean ± SEM of three independent experiments performed each time in triplicate; * = p<0.05, ** = p<0.01 compared to lower concentration at each time point.
S8661	CA3(CIL56) CA3(CIL56) 对YAP1/Tead转录活性具有有效的抑制作用，主要靶向高表达YAP1、具有癌症干细胞属性的、难治疗的食管腺癌细胞。CA3(CIL56)可诱导铁死亡和铁依赖的活性氧自由基。	J Neurosci, 2020, 13;40(20):3915-3932 Artif Cells Nanomed Biotechnol, 2020, 48(1):920-932 Mol Cancer Res, 2019, 17(10):2029-2041
S8877^New	Imidazole ketone erastin Imidazole ketone erastin (IKE)是一种有效的、代谢稳定的、选择性system xc–抑制剂以及ferroptosis诱导剂。
S8790	ML385 ML385是一种新型的、特异的NRF2抑制剂，IC50为1.9 μM。它能抑制NRF2的下游靶基因的表达。NRF2 可调节多种铁死亡和脂质过氧化相关蛋白的活性。	Front Immunol, 2020, 10:2969 Oxid Med Cell Longev, 2020, 12;2020:1898213 Med Sci Monit, 2020, 26;26:e923251

目录号	产品描述	文献引用	实验数据
S1077	SB202190 (FHPI) SB202190 (FHPI)是一种有效的p38 MAPK抑制剂，靶向作用于p38α/β，无细胞试验中IC50为50 nM/100 nM，有时用于代替SB 203580研究其在体内对SAPK2a/p38的潜在作用。SB202190 可通过诱导自噬和血红素氧化酶1来抑制内皮细胞的凋亡。SB202190可显著抑制Erastin依赖的铁死亡ferroptosis。	Redox Biol,2020, 28:101445 Cells,2020, 13;9(5) pii: E1209 Cells,2020, 28;9(4) pii: E822	C, Jurkat cells with SB202190 at 1, 5, and 10 μM were tested, and a decreased SRP72 expression was found when using at 10 μM (lanes 8 and 9). D, results were analyzed and RUA illustrated, finding significant results at 10 μM at 240 versus 0 and 120 versus 0 min (p<0.05).
S0788^New	ML 210 ML-210 是一种选择性的 glutathione peroxidase 4 (GPX4) 的共价抑制剂，其EC50值为0.04 μM，可诱导铁死亡。ML-210 可以选择性地杀死诱导表达突变型 RAS 的细胞，并具有抗癌活性。
S2505	Rosiglitazone maleate Rosiglitazone maleate 是一种噻唑烷二酮类抗高血糖药，是PPARγ的高亲和、选择性的激动剂，IC50为42 nM。Rosiglitazone maleate 也能调节 TRP channels并诱导自噬。Rosiglitazone 可预防铁死亡。	Virol Sin,2019, 34(6):648-661 Drugs R D,2017, 10.1007/s40268-016-0166-4 J Inflamm (Lond),2016, 13:19	Total and phosphorylated Akt were detected by western blot in protein lysates of liver, inguinal WAT and gastrocnemius muscle from mice that were treated with an insulin bolus after an overnight fast.
S2556	Rosiglitazone Rosiglitazone 是有效的降糖药，也是有效的噻唑烷二酮类胰岛素增敏剂，在大鼠，3T3-L1和人体脂肪细胞中IC50分别为12，4和9 nM。Rosiglitazone是PPAR-gamma的配体，对PPAR-alpha没有结合力。Rosiglitazone 可调控 TRP channels 并诱导自噬。Rosiglitazone可阻止铁死亡。	Nat Commun,2020, 11(1):71 Cancer Cell Int,2020, 19;20:58 Cancer Chemother Pharmacol,2020, 85(2):273-284
S1623	Acetylcysteine(N-acetylcysteine) Acetylcysteine(N-acetyl-l-cysteine)是ROS抑制剂，拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂，主要用作祛痰剂，可通过维持或恢复肝脏中谷胱甘肽的浓度来处理扑热息痛(对乙酰氨基酚过量)。Acetylcysteine(N-acetyl-l-cysteine) 通过抑制IκB kinases抑制TNF诱导的NF-κB活化。Acetylcysteine(N-acetyl-l-cysteine) 通过线粒体依赖性途径诱导凋亡并抑制铁死亡和病毒复制。现配现用。	Cell Death Differ,2020, 10.1038/s41418-020-0496-1 J Hazard Mater,2020, 5;391:122203 Oxid Med Cell Longev,2020, 13;2020:3145182	(C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.
S7243	Ferrostatin-1 (Fer-1) Ferrostatin-1 (Fer-1)是一种有效的选择性的ferroptosis抑制剂，EC50为60 nM。	ACS Nano,2020, 24;14(3):3414-3425 Nat Commun,2020, 23;11(1):433 Nat Commun,2020, 6;11(1):1251	Indicated HCC cells were treated with sorafenib (5 µM) and erastin (10 µM) with or without cell death inhibitors (ferrostatin-1, 1 µM; liprostatin-1, 100nM; ZVAD-FMK,10 µM; necrosulfonamide, 0.5 µM) for 24 hours and cell viability was assayed (n=3, *p < 0.05 versus sorafenib or erastin treatment group).
S7699	Liproxstatin-1 Liproxstatin-1是一种有效的ferroptosis抑制剂，IC50为22 nM。	Nat Commun,2020, 23;11(1):433 Sci Adv,2020, 25;6(13):eaay9789 Autophagy,2020, 18;1-13	(D) Indicated NRF2 knockdown HCC cells were treated with erastin (10 μM) and sorafenib (5 μM) with or without indicated inhibitors (ferrostatin-1, 1 μM; liproxstatin-1, 100 nM; ZVAD-FMK, 10 μM; necrostatin-1, 10 μM; necrosulfonamide, 0.5 μM) for 24 hours, and cell viability was assayed (n 5 3, *P < 0.05). Abbreviation: GAPDH, glyceraldehyde 3-phosphate dehydrogenase.
S8792	UAMC-3203 UAMC-3203是ferroptosis抑制剂，在IMR-32神经母细胞瘤细胞中IC50为10 nM。

目录号	产品描述	文献引用	实验数据
S1040	Sorafenib Tosylate Sorafenib Tosylate 是Raf-1和B-Raf的多重激酶抑制剂，无细胞试验中IC50分别为6 nM和22 nM。Sorafenib 还可抑制VEGFR-2、VEGFR-3、PDGFR-β、Flt-3和c-KIT，对应的IC50值分别为90 nM、20 nM、57 nM、59 nM和68 nM。Sorafenib Tosylate 可诱导autophagy、apoptosis并激活ferroptosis，并具有抗肿瘤活性。	Elife, 2020, 22;9:e51358 J Exp Clin Cancer Res, 2020, 39(1):24 Cancers (Basel), 2020, 27;12(5)pii: E1087	Inhibition of breast cancer cell growth using sorafenib. MCF-7 breast cancer cells were treated with increasing concentrations of sorafenib for 5 days. Cell number was measured using a colorimetric growth assay (crystal violet stain) and expressed relative to DMSO treated control cells.
S1166	Cisplatin Cisplatin 是一种无机铂络合物，在肿瘤细胞中能够通过形成DNA加合物抑制 DNA synthesis。Cisplatin 可激活ferroptosis并诱导autophagy。建议现配现用。	Cancer Cell, 2020, 37(2):157-167 Cancer Cell, 2020, 37(3):371-386 Cancer Cell, 2020, 13;37(1):104-122e12	Cell viabilities with increasing concentrations of cisplatin (CP) and doxorubicin (DOXO) under normoxic and hypoxic condition for 48 hours were determined by MTT assay. IC50 values are presented as the means ?SDs (n=4) and * denotes p<0.05.
S1007	Roxadustat (FG-4592) Roxadustat (FG-4592)在无细胞试验中是一种HIF-α脯氨酰羟化酶抑制剂，并能稳定HIF-2，同时诱导EPO产生。Roxadustat可加强RSL3诱导的 ferroptosis。Phase 3。	J Med Chem, 2020, 31 J Exp Clin Cancer Res, 2020, 39(1):24 FASEB J, 2020, 34(2):2344-2358	Immunoblots showing dose-dependent HIF-1α stabilization in U2OS, HeLa and Hep3b (and HIF-2α) cells after 6 hours treatment with FG-4592.
S2111	Lapatinib Lapatinib，以 Lapatinib Ditosylate的形式使用，是一种有效的EGFR和ErbB2抑制剂，在无细胞试验中IC50分别为10.2和9.8 nM。Lapatinib 可诱导 ferroptosis 和细胞自噬。	Acta Neuropathol, 2020, 17 Nat Commun, 2020, 11(1):385 Nat Commun, 2020, 25;11(1):1556	Aberrantly activated PI3K/AKT pathway mediates lapatinib resistance in SK-BR-3-LR cells. (A and B) After drug treatment, phosphorylation of HER2, EGFR, AKT, and ERK1/2 was determined by Western blotting using speciﬁc antibodies.
S1792	Simvastatin Simvastatin 是一种HMG-CoA reductase竞争性抑制剂，无细胞试验中K_i为0.1-0.2 nM。Simvastatin可诱导铁死亡、线粒体自噬、细胞自噬和凋亡。	Aging (Albany NY), 2020, 44187 Vaccines (Basel), 2020, 6;8(1):72 Sci Rep, 2020, 10(1):931	Statin-Related Inhibition of Dehydroepiandrosterone Sulfate (DHEAS) Uptake by SLCO2B1 in Prostate Cancer (PC) Cells. B, Uptake of DHEAS in PC cells with 2.5 µM DHEAS and different concentrations of statins when incubated for 60 minutes. Statistical analysis was performed by comparing each condition with the DHEAS 2.5 µM and no statin state except when indicated. C, Uptake of DHEAS in PC cells before (scrambled short hairpin RNA) and after (short hairpin RNA 2B1) SLCO2B1 is knocked down when incubated with 2.5 μM DHEAS and 100 μM atorvastatin for 10 and 60 minutes. Statistical analysis was performed by comparing each condition with scrambled short hairpin RNA after 10 minutes with DHEAS except when indicated. P = .02 for the comparison between scrambled short hairpin RNA with 10 vs 60 minutes of DHEAS incubation for LNCaP and .01 for 22RV1. Other P values are indicated in the figure. Bars indicate means and error bars indicate standard deviation.
S7397	Sorafenib Sorafenib 是Raf-1和B-Raf的多重激酶抑制剂，无细胞试验中IC50分别为6 nM和22 nM。Sorafenib 还可抑制VEGFR-2、VEGFR-3、PDGFR-β、Flt-3和c-KIT，对应的IC50值分别为90 nM、20 nM、57 nM、59 nM和68 nM。Sorafenib 可诱导autophagy、apoptosis并激活ferroptosis，Sorafenib 具有抗肿瘤活性。	Cell Metab, 2020, 5;31(5):892-908 e11 Autophagy, 2020, 10.1080/15548627.2019.1709762 Cell Rep, 2020, 31(2):107514	Involvement of EV linc-VLDLR in tumor cell responses to chemotherapy. Cells were incubated with sorafenib, camptothecin, or doxorubicin. EVs were obtained after 24 hours, and qRT-PCR was performed for linc-VLDLR. The bars represent the mean ?SEM of the increase in cell viability from 3 independent studies. *, P < 0.05.
S7242	Erastin Erastin是一种ferroptosis激活剂，通过作用于线粒体VDAC而起作用，选择性作用于携带致癌基因RAS的肿瘤细胞。	Nat Chem Biol, 2020, 6 Nat Commun, 2020, 23;11(1):433 Sci Adv, 2020, 25;6(13):eaay9789	Western blot analysis indicated protein expression in PDAC cells following treatment with erastin (2.5-40 μmol/L) for 24 hours (n=3, * P < 0.05 vs. untreated group)
S8254	FIN56 FIN56是ferroptosis的特异性诱导剂。	Dev Cell, 2019, 10.1016/j.devcel.2019.10.007 Biochem Biophys Res Commun, 2019, 510(2):278-283 Curr Biol, 2018, 28(15):2388-2399
S8155	RSL3 RSL3是一种ferroptosis的激活剂，不依赖于VDAC，对携带致瘤性RAS的肿瘤细胞具有选择性。它结合并使GPX4失活，介导GPX4所调节的铁死亡。	Nat Cell Biol, 2020, 22(2):225-234 Autophagy, 2020, 18;1-13 Theranostics, 2020, 6;10(11):5107-5119	(D) Representative western blot and (E) densitometry showing protein levels of HO-1 in HO-1+/+ PTCs treated with RSL3 over time. Data shown represent the Mean ± SEM of three independent experiments performed each time in triplicate; * = p<0.05, ** = p<0.01 compared to lower concentration at each time point.
S8661	CA3(CIL56) CA3(CIL56) 对YAP1/Tead转录活性具有有效的抑制作用，主要靶向高表达YAP1、具有癌症干细胞属性的、难治疗的食管腺癌细胞。CA3(CIL56)可诱导铁死亡和铁依赖的活性氧自由基。	J Neurosci, 2020, 13;40(20):3915-3932 Artif Cells Nanomed Biotechnol, 2020, 48(1):920-932 Mol Cancer Res, 2019, 17(10):2029-2041

目录号	产品描述	文献引用	实验数据
S8877^New	Imidazole ketone erastin Imidazole ketone erastin (IKE)是一种有效的、代谢稳定的、选择性system xc–抑制剂以及ferroptosis诱导剂。
S8790	ML385 ML385是一种新型的、特异的NRF2抑制剂，IC50为1.9 μM。它能抑制NRF2的下游靶基因的表达。NRF2 可调节多种铁死亡和脂质过氧化相关蛋白的活性。	Front Immunol, 2020, 10:2969 Oxid Med Cell Longev, 2020, 12;2020:1898213 Med Sci Monit, 2020, 26;26:e923251

目录号

产品描述

文献引用

实验数据

S8877^New