Ferroptosis

抑制剂选择性比较

Ferroptosis产品

所有产品 Ferroptosis抑制剂(3) Ferroptosis激活剂(3) 新Ferroptosis产品

产品目录	产品描述	文献引用	实验数据
S7243	Ferrostatin-1 (Fer-1) Ferrostatin-1 (Fer-1)是一种有效的选择性的ferroptosis抑制剂，EC50为60 nM。	Cell Death Differ, 2019, 10.1038/s41418-019-0338-1 Front Neurosci, 2019, 13:721 Am J Transl Res, 2019, 11(2):875-884	Indicated HCC cells were treated with sorafenib (5 µM) and erastin (10 µM) with or without cell death inhibitors (ferrostatin-1, 1 µM; liprostatin-1, 100nM; ZVAD-FMK,10 µM; necrosulfonamide, 0.5 µM) for 24 hours and cell viability was assayed (n=3, *p < 0.05 versus sorafenib or erastin treatment group).
S7699	Liproxstatin-1 Liproxstatin-1是一种有效的ferroptosis抑制剂，IC50为22 nM。	Cell Death Differ, 2019, 10.1038/s41418-019-0299-4 Biochem Biophys Res Commun, 2019, 510(2):278-283 Arch Toxicol, 2018, 92(4):1507-1524	(D) Indicated NRF2 knockdown HCC cells were treated with erastin (10 μM) and sorafenib (5 μM) with or without indicated inhibitors (ferrostatin-1, 1 μM; liproxstatin-1, 100 nM; ZVAD-FMK, 10 μM; necrostatin-1, 10 μM; necrosulfonamide, 0.5 μM) for 24 hours, and cell viability was assayed (n 5 3, *P < 0.05). Abbreviation: GAPDH, glyceraldehyde 3-phosphate dehydrogenase.
S8792^New	UAMC-3203 UAMC-3203是ferroptosis抑制剂，在IMR-32神经母细胞瘤细胞中IC50为10 nM。
S7242	Erastin Erastin是一种ferroptosis激活剂，通过作用于线粒体VDAC而起作用，选择性作用于携带致癌基因RAS的肿瘤细胞。	Cell Metab, 2019, 29(5):1217-1231 Cell Death Differ, 2019, 10.1038/s41418-019-0338-1 Am J Cancer Res, 2019, 9(4):730-739	Western blot analysis indicated protein expression in PDAC cells following treatment with erastin (2.5-40 μmol/L) for 24 hours (n=3, * P < 0.05 vs. untreated group)
S8254	FIN56 FIN56是ferroptosis的特异性诱导剂。	Biochem Biophys Res Commun, 2019, 510(2):278-283
S8155	RSL3 RSL3是一种ferroptosis的激活剂，不依赖于VDAC，对携带致瘤性RAS的肿瘤细胞具有选择性。它结合并使GPX4失活，介导GPX4所调节的铁死亡。	Nature, 2019, 567(7746):118-122 Cell Metab, 2019, 29(5):1217-1231 Cell Death Discov, 2019, 5:65	(D) Representative western blot and (E) densitometry showing protein levels of HO-1 in HO-1+/+ PTCs treated with RSL3 over time. Data shown represent the Mean ± SEM of three independent experiments performed each time in triplicate; * = p<0.05, ** = p<0.01 compared to lower concentration at each time point.

产品目录	产品描述	文献引用	实验数据
S7243	Ferrostatin-1 (Fer-1) Ferrostatin-1 (Fer-1)是一种有效的选择性的ferroptosis抑制剂，EC50为60 nM。	Cell Death Differ,2019, 10.1038/s41418-019-0338-1 Front Neurosci,2019, 13:721 Am J Transl Res,2019, 11(2):875-884	Indicated HCC cells were treated with sorafenib (5 µM) and erastin (10 µM) with or without cell death inhibitors (ferrostatin-1, 1 µM; liprostatin-1, 100nM; ZVAD-FMK,10 µM; necrosulfonamide, 0.5 µM) for 24 hours and cell viability was assayed (n=3, *p < 0.05 versus sorafenib or erastin treatment group).
S7699	Liproxstatin-1 Liproxstatin-1是一种有效的ferroptosis抑制剂，IC50为22 nM。	Cell Death Differ,2019, 10.1038/s41418-019-0299-4 Biochem Biophys Res Commun,2019, 510(2):278-283 Arch Toxicol,2018, 92(4):1507-1524	(D) Indicated NRF2 knockdown HCC cells were treated with erastin (10 μM) and sorafenib (5 μM) with or without indicated inhibitors (ferrostatin-1, 1 μM; liproxstatin-1, 100 nM; ZVAD-FMK, 10 μM; necrostatin-1, 10 μM; necrosulfonamide, 0.5 μM) for 24 hours, and cell viability was assayed (n 5 3, *P < 0.05). Abbreviation: GAPDH, glyceraldehyde 3-phosphate dehydrogenase.
S8792^New	UAMC-3203 UAMC-3203是ferroptosis抑制剂，在IMR-32神经母细胞瘤细胞中IC50为10 nM。

产品目录

产品描述

文献引用

实验数据

S7243

Ferrostatin-1 (Fer-1)

Ferrostatin-1 (Fer-1)是一种有效的选择性的ferroptosis抑制剂，EC50为60 nM。

Cell Death Differ,2019, 10.1038/s41418-019-0338-1

Front Neurosci,2019, 13:721

Am J Transl Res,2019, 11(2):875-884

S7699

Liproxstatin-1

Liproxstatin-1是一种有效的ferroptosis抑制剂，IC50为22 nM。

Cell Death Differ,2019, 10.1038/s41418-019-0299-4

Biochem Biophys Res Commun,2019, 510(2):278-283

Arch Toxicol,2018, 92(4):1507-1524

S8792^New

UAMC-3203

UAMC-3203是ferroptosis抑制剂，在IMR-32神经母细胞瘤细胞中IC50为10 nM。

产品目录	产品描述	文献引用	实验数据
S7242	Erastin Erastin是一种ferroptosis激活剂，通过作用于线粒体VDAC而起作用，选择性作用于携带致癌基因RAS的肿瘤细胞。	Cell Metab, 2019, 29(5):1217-1231 Cell Death Differ, 2019, 10.1038/s41418-019-0338-1 Am J Cancer Res, 2019, 9(4):730-739	Western blot analysis indicated protein expression in PDAC cells following treatment with erastin (2.5-40 μmol/L) for 24 hours (n=3, * P < 0.05 vs. untreated group)
S8254	FIN56 FIN56是ferroptosis的特异性诱导剂。	Biochem Biophys Res Commun, 2019, 510(2):278-283
S8155	RSL3 RSL3是一种ferroptosis的激活剂，不依赖于VDAC，对携带致瘤性RAS的肿瘤细胞具有选择性。它结合并使GPX4失活，介导GPX4所调节的铁死亡。	Nature, 2019, 567(7746):118-122 Cell Metab, 2019, 29(5):1217-1231 Cell Death Discov, 2019, 5:65	(D) Representative western blot and (E) densitometry showing protein levels of HO-1 in HO-1+/+ PTCs treated with RSL3 over time. Data shown represent the Mean ± SEM of three independent experiments performed each time in triplicate; * = p<0.05, ** = p<0.01 compared to lower concentration at each time point.

产品目录

产品描述

文献引用

实验数据

S7242