MLL

特异性亚型抑制剂

• Menin-MLL interaction Selective

MLL产品

目录号	产品描述	文献引用	实验数据
S7265	MM-102 MM-102 (HMTase Inhibitor IX)是一个高亲和力的多肽模拟的MLL1抑制剂，无细胞试验中IC50为0.4 μM。	J Cell Mol Med, 2020, 10.1111/jcmm.16030 Mol Carcinog, 2020, 10.1002/mc.23147 Front Genet, 2020, 11:80	Immunofluorescence staining of H3K4me2/3 (red) in the IVF, SCNT and MM-102-NT embryos. The nuclei (blue) were stained with DAPI. The merged images of H3K4me2/3 and DNA were purple. Scale bars: 50 μm.
S7816	MI-463 MI-463是Menin-MLL interaction的有效抑制剂，IC50为15.3 nM。	Front Oncol, 2020, 10:524922
S7817	MI-503 MI-503是一种有效的、选择性的Menin-MLL抑制剂，IC50为14.7 nM。在人类MLL白血病细胞系中，具有显著的生长抑制效果（GI=250 nM-570 nM），但是在不具有MLL易位的人类白血病细胞中，效果甚微。	J Assoc Res Otolaryngol, 2021, 10.1007/s10162-021-00801-7 Cancers (Basel), 2020, 12(9)E2715 Int J Pediatr Otorhinolaryngol, 2020, 140:110545
S7619	MI-3 (Menin-MLL Inhibitor) MI-3 (Menin-MLL Inhibitor)是一种强效的menin-MLL相互作用抑制剂，IC50为 648 nM。	Clin Epigenetics, 2019, 11(1):137 Cancer Res, 2018, 78(20):5731-5740 PLoS Genet, 2016, 12(2):e1005884
S8934	VTP50469 VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity.
S8996New	SNDX-5613 SNDX-5613是一种有效且选择性的menin-MLL binding抑制剂，Ki为0.15 nM。SNDX-5613 对多种携带MLLr易位的细胞系(MV4;11, RS4;11, MOLM-13, KOPN-8)显示出抗增殖活性，IC50值范围为 10-20 nM。
S7618	MI-2 (Menin-MLL Inhibitor) MI-2 (Menin-MLL Inhibitor)是一种有效的menin-MLL相互作用抑制剂，IC50为446 nM。	J Immunol, 2021, ji1901348 Cell Rep, 2019, 26(2):415-428 Endocrinology, 2019, 10.1210/en.2019-00274
S7815	MI-136 MI-136抑制DHT所诱导的雄激素受体(AR)靶向基因的表达。	J Med Chem, 2020, 31

目录号	产品描述	文献引用	实验数据
S7265	MM-102 MM-102 (HMTase Inhibitor IX)是一个高亲和力的多肽模拟的MLL1抑制剂，无细胞试验中IC50为0.4 μM。	J Cell Mol Med,2020, 10.1111/jcmm.16030 Mol Carcinog,2020, 10.1002/mc.23147 Front Genet,2020, 11:80	Immunofluorescence staining of H3K4me2/3 (red) in the IVF, SCNT and MM-102-NT embryos. The nuclei (blue) were stained with DAPI. The merged images of H3K4me2/3 and DNA were purple. Scale bars: 50 μm.
S7816	MI-463 MI-463是Menin-MLL interaction的有效抑制剂，IC50为15.3 nM。	Front Oncol,2020, 10:524922
S7817	MI-503 MI-503是一种有效的、选择性的Menin-MLL抑制剂，IC50为14.7 nM。在人类MLL白血病细胞系中，具有显著的生长抑制效果（GI=250 nM-570 nM），但是在不具有MLL易位的人类白血病细胞中，效果甚微。	J Assoc Res Otolaryngol,2021, 10.1007/s10162-021-00801-7 Cancers (Basel),2020, 12(9)E2715 Int J Pediatr Otorhinolaryngol,2020, 140:110545
S7619	MI-3 (Menin-MLL Inhibitor) MI-3 (Menin-MLL Inhibitor)是一种强效的menin-MLL相互作用抑制剂，IC50为 648 nM。	Clin Epigenetics,2019, 11(1):137 Cancer Res,2018, 78(20):5731-5740 PLoS Genet,2016, 12(2):e1005884
S8934	VTP50469 VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity.
S8996New	SNDX-5613 SNDX-5613是一种有效且选择性的menin-MLL binding抑制剂，Ki为0.15 nM。SNDX-5613 对多种携带MLLr易位的细胞系(MV4;11, RS4;11, MOLM-13, KOPN-8)显示出抗增殖活性，IC50值范围为 10-20 nM。
S7618	MI-2 (Menin-MLL Inhibitor) MI-2 (Menin-MLL Inhibitor)是一种有效的menin-MLL相互作用抑制剂，IC50为446 nM。	J Immunol,2021, ji1901348 Cell Rep,2019, 26(2):415-428 Endocrinology,2019, 10.1210/en.2019-00274
S7815	MI-136 MI-136抑制DHT所诱导的雄激素受体(AR)靶向基因的表达。	J Med Chem,2020, 31