Menin-MLL-interaction 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S8934 VTP50469

VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity.

Selective Menin-MLL interaction, Ki: 104 pM; Menin-MLL interaction, Ki: 104 pM; Menin-MLL interaction, Ki: 104 pM; Menin-MLL interaction, Ki: 104 pM; Menin-MLL interaction, Ki: 104 pM; Menin-MLL interaction, Ki: 104 pM; Menin-MLL interaction, Ki: 104 pM; Menin-MLL interaction, Ki: 104 pM
S8934 VTP50469

VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity.

Selective Menin-MLL interaction, Ki: 104 pM; Menin-MLL interaction, Ki: 104 pM; Menin-MLL interaction, Ki: 104 pM; Menin-MLL interaction, Ki: 104 pM; Menin-MLL interaction, Ki: 104 pM; Menin-MLL interaction, Ki: 104 pM; Menin-MLL interaction, Ki: 104 pM; Menin-MLL interaction, Ki: 104 pM
S7817 MI-503

MI-503是一种有效的、选择性的Menin-MLL抑制剂,IC50为14.7 nM。在人类MLL白血病细胞系中,具有显著的生长抑制效果(GI=250 nM-570 nM),但是在不具有MLL易位的人类白血病细胞中,效果甚微。

Selective Menin-MLL interaction, IC50: 14.7 nM
S7817 MI-503

MI-503是一种有效的、选择性的Menin-MLL抑制剂,IC50为14.7 nM。在人类MLL白血病细胞系中,具有显著的生长抑制效果(GI=250 nM-570 nM),但是在不具有MLL易位的人类白血病细胞中,效果甚微。

Selective Menin-MLL interaction, IC50: 14.7 nM
S7816 MI-463

MI-463是Menin-MLL interaction的有效抑制剂,IC50为15.3 nM。

Selective Menin-MLL interaction, IC50: 15.3 nM
S7816 MI-463

MI-463是Menin-MLL interaction的有效抑制剂,IC50为15.3 nM。

Selective Menin-MLL interaction, IC50: 15.3 nM
S7618 MI-2 (Menin-MLL Inhibitor)

MI-2 (Menin-MLL Inhibitor)是一种有效的menin-MLL相互作用抑制剂,IC50为446 nM。

Selective Menin-MLL interaction, IC50: 446 nM
S7618 MI-2 (Menin-MLL Inhibitor)

MI-2 (Menin-MLL Inhibitor)是一种有效的menin-MLL相互作用抑制剂,IC50为446 nM。

Selective Menin-MLL interaction, IC50: 446 nM
S7619 MI-3 (Menin-MLL Inhibitor)

MI-3 (Menin-MLL Inhibitor)是一种强效的menin-MLL相互作用抑制剂,IC50为 648 nM。

Selective Menin-MLL interaction, IC50: 648 nM
S7619 MI-3 (Menin-MLL Inhibitor)

MI-3 (Menin-MLL Inhibitor)是一种强效的menin-MLL相互作用抑制剂,IC50为 648 nM。

Selective Menin-MLL interaction, IC50: 648 nM
S7815 MI-136

MI-136抑制DHT所诱导的雄激素受体(AR)靶向基因的表达。

Selective
S7815 MI-136

MI-136抑制DHT所诱导的雄激素受体(AR)靶向基因的表达。

Selective
S7833 OICR-9429

OICR-9429是一种有效的WDR5-MLLWDR5-Histone3相互作用的拮抗剂,能在体外实验中降低急性髓性白血病细胞的活性。它与WDR5高亲和结合,Kd值为93 ± 28 nM。

Pan WDR5, Kd: 93 nM
S2184 WDR5-0103

WDR5-0103 (WD-Repeat Protein 5-0103) is a small-molecule antagonist of WDR5 (WD40 repeat protein 5) with Kd of 450 nM.

Pan WDR5, Kd: 450 nM