Tamoxifen (ICI 46474)

For research use only. Not for use in humans.

目录号:S1238 别名: (Z)-Tamoxifen, trans-Tamoxifen 中文名称:他莫昔芬

Tamoxifen (ICI 46474) Chemical Structure

CAS No. 10540-29-1

Tamoxifen (ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen) 作用于乳腺组织,是一种雌激素受体estrogen receptor调节剂 (SERM)。Tamoxifen可增强Hsp90分子伴侣ATPase的活性。Tamoxifen可诱导凋亡。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1286.18 现货
RMB 1200.67 现货
RMB 2443.76 现货
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客户使用Selleck生产的Tamoxifen (ICI 46474)发表文献41篇:

产品安全说明书

Antineoplastic and Immunosuppressive Antibiotics抑制剂选择性比较

生物活性

产品描述 Tamoxifen (ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen) 作用于乳腺组织,是一种雌激素受体estrogen receptor调节剂 (SERM)。Tamoxifen可增强Hsp90分子伴侣ATPase的活性。Tamoxifen可诱导凋亡。
靶点
estrogen receptor [1]
体外研究

TAM的处理可显著地抑制MCF7细胞增殖。低浓度的TAM可以在ER+和ER-的乳腺癌细胞中诱导染色体结构畸变(缺失、等臂、易位、双着丝染色体)。在HER2基因扩增的细胞系中,这种基因毒性作用更大[2]。低浓度的TAM(0.1-1 μM)诱导细胞周期阻滞,而药物浓度(大于5 μM)则诱导乳腺癌细胞的凋亡。5 μM TAM在ER+乳腺癌细胞(MCF-7、T47D)中快速诱导持续性的ERK1/2激活[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA-MB-435 cells NYqxd21LTnWwY4Tpc44h[XO|YYm= NIjFcJRKdmirYnn0bY9vKG:oIF3ERU1OSi12M{WgZpJm[XO2IHPhcoNmeiClZXzsJJBzd2yrZnXyZZRqd25uIFnDOVA:OC5yNTFOwG0> MlLRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR7N{G4PVkoRjF2OUexPFk6RC:jPh?=
MDA-MB-231 cells NX7tNZE2TnWwY4Tpc44h[XO|YYm= M4TSfWlvcGmkaYTpc44hd2ZiZYP0do9o\W5icnXj[ZB1d3JibnXnZZRqfmViTVTBMW1DNTJ|MTDidoVie3RiY3HuZ4VzKGOnbHygdJJwdGmoZYLheIlwdixiSVO1NF0xNjB6IN88US=> NFy1Xmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEm3NVg6QSd-MUS5O|E5QTl:L3G+
MCF7 NVnv[5NxSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NWjCRVFxPzJiaILz MnPORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGFkfGm4aYT5JF0hPC54IN88UU4> NV24cnF{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5NVg5OjBpPkG3PVE5QDJyPD;hQi=>
MCF7 MYLBcpRq\XO2cn;n[Y5q[yCjc4PhfS=> M2nCPVk3KGi{cx?= M4fXZmFvfGmnc4Tyc4dmdmmlIHHjeIl3cXS7IHnuJIh2dWGwIF3DSlch[2WubIOgZZN{\XO|ZXSgZZMh\HK3ZzDs[ZZmdCClYYXzbY5oKGmwaHnibZRqd25ib3[gNVAxKHCPIFWyMYVvcGGwY3XkJINmdGxicILvcIln\XKjdHnvckB1dyCuZY\lcEBmeXWrdnHs[Y51KHSxIEWwJJBOKEV{IHHmeIVzKDl4IHjyd{BjgSCjbHHtZZIh[my3ZTDhd5NigSxiQXP0bZZqfHliPTCwMlEh|ryPLh?= NHzFRYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm0N|YzOCd-MUm5OFM3OjB:L3G+
T47D NXW2NZQ5SW62aXXzeJJw\2WwaXOgZZN{[Xl? MmfUPVYhcHK| MojQRY51cWW|dILv[4VvcWNiYXP0bZZqfHliaX6gbJVu[W5iVES3SEBk\WyuczDhd5Nme3OnZDDhd{BlenWpIHzleoVtKGOjdYPpcochcW6qaXLpeIlwdiCxZjCxNFAheE1iRUKt[Y5p[W6lZXSgZ4VtdCCycn;sbYZmemG2aX;uJJRwKGyndnXsJIVyfWm4YXzlcpQhfG9iNUCgdG0hTTJiYX\0[ZIhQTZiaILzJIJ6KGGuYX3hdkBjdHWnIHHzd4F6NCCDY4Tpeol1gSB;IECuNUDPxE1w NVrjfIpMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5OFM3OjBpPkG5PVQ{PjJyPD;hQi=>
MCF7 M{TuTmFvfGmnc4Tyc4dmdmmlIHHzd4F6 MoP2PVYhcHK| NEmzS3BCdnSrZYP0do9o\W6rYzDhZ5Rqfmm2eTDpckBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGS{dXegcIV3\WxiY3H1d4lv\yCrbnjpZol1cW:wIH;mJFExOCCyTTDFNk1mdmijbnPl[EBk\WyuIIDyc4xq\mW{YYTpc44hfG9ibHX2[Ywh\XG3aY\hcIVvfCC2bzCxNEBxVSCHMjDh[pRmeiB7NjDodpMh[nliYXzhcYFzKGKudXWgZZN{[XluIFHjeIl3cXS7IE2gNE4zKM7:TT6= MkLQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7NEO2NlAoRjF7OUSzOlIxRC:jPh?=
MCF7 M2TUVWFvfGmnc4Tyc4dmdmmlIHHzd4F6 NHL4U246PiCqcoO= Ml3sRY51cWW|dILv[4VvcWNiYXP0bZZqfHliaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{BlenWpIHzleoVtKGOjdYPpcochcW6qaXLpeIlwdiCxZjCxNFAheE1iRUKt[Y5p[W6lZXSgZ4VtdCCycn;sbYZmemG2aX;uJJRwKGyndnXsJIVyfWm4YXzlcpQhfG9iMTDwUUBGOiCjZoTldkA6PiCqcoOgZpkh[WyjbXHyJIJtfWViYYPzZZktKEGldHn2bZR6KD1iMD60JO69VS5? NGDrW2U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm0N|YzOCd-MUm5OFM3OjB:L3G+
T47D NWDw[ZRvSW62aXXzeJJw\2WwaXOgZZN{[Xl? MVG5OkBpenN? MXrBcpRq\XO2cn;n[Y5q[yCjY4Tpeol1gSCrbjDoeY1idiCWNEfEJINmdGy|IHHzd4V{e2WmIHHzJIRzfWdibHX2[Ywh[2G3c3nu[{BqdmirYnn0bY9vKG:oIEGwNEBxVSCHMj3lcohidmOnZDDj[YxtKHC{b3zp[oVz[XSrb36geI8hdGW4ZXyg[ZF2cX[jbHXueEB1dyBzMDDwUUBGOiCjZoTldkA6PiCqcoOgZpkh[WyjbXHyJIJtfWViYYPzZZktKEGldHn2bZR6KD1iMD63JO69VS5? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl2M{[yNEc,OTl7NEO2NlA9N2F-
T47D NXuyNZlpSW62aXXzeJJw\2WwaXOgZZN{[Xl? NIC5UoY6PiCqcoO= NW\xemVNSW62aXXzeJJw\2WwaXOgZYN1cX[rdImgbY4hcHWvYX6gWFQ4TCClZXzsd{Bie3Onc4Pl[EBieyCmcoXnJIxmfmWuIHPheZNqdmdiaX7obYJqfGmxbjDv[kAyODBicF2gSVIu\W6qYX7j[YQh[2WubDDwdo9tcW[ncnH0bY9vKHSxIHzleoVtKGWzdXn2ZYxmdnRidH:gNUBxVSCHMjDh[pRmeiB7NjDodpMh[nliYXzhcYFzKGKudXWgZZN{[XluIFHjeIl3cXS7IE2gPUDPxE1w M3fRdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUSzOlIxLz5zOUm0N|YzODxxYU6=
HepG2 M37vNWN6fG:2b4jpZ4l1gSCjc4PhfS=> NYPwc|JCOjRiaILz MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCyOEBpenNiYomgdoV{[Xq3cnnuJIR6\S2kYYPl[EBndHWxcnXzZ4Vv[2ViYX7hcJl{cXNuIFPDOVAhRSB{ND63JO69VS5? M4DJWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyM{KyO|U1Lz5|MEOyNlc2PDxxYU6=
HEK293 M3W4eGN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml\TNlQhcHK| NVPlb29VS3m2b4TvfIlkcXS7IHHnZYlve3RiSFXLNlk{KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDy[ZNignW{aX6g[JlmNWKjc3XkJIZtfW:{ZYPj[Y5k\SCjbnHsfZNqeyxiQ1O1NEA:KDN7LkSg{txONg>? MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODN{Mke1OEc,OzB|MkK3OVQ9N2F-
MCF-7 MoLMR5l1d3SxeHnjbZR6KGG|c3H5 NYjaXXdmS3m2b4TvfIlkcXS7IHHnZYlve3RiTVPGMVch[2WubIOgbY4hfGinIHHid4Vv[2Vib3[gNUB2VSCHMjCo[ZN1emGmaX;sLUwhS3m2b4TvfIlkcXS7IE2gPU45KM7:TT6= M{X0d|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzlyOEmzN|IoRjlyOEmzN|I9N2F-
MCF-7 M13HfGN6fG:2b4jpZ4l1gSCjc4PhfS=> NVjmT5FlS3m2b4TvfIlkcXS7IHHnZYlve3RiTVPGMVch[2WubIOgbY4heHKnc3XuZ4Uhd2ZiMTD1UUBGOiBqZYP0doFlcW:uKTygR5l1d3SxeHnjbZR6KD1iMUOg{txONg>? NFnse5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97MEi5N|MzLz57MEi5N|MzRC:jPh?=
MCF-7 NGPVPGZHfW6ldHnvckBie3OjeR?= NFHtNVRG\m[nY4TpeoUh\G:|ZTDmc5IhYzOKXT2g[ZN1emGmaX;sJIFo[Wmwc4SgdJJwdGmoZYLheIlwdiCxZjDNR2YuPyClZXzsd{whTUN3MDC9JFAvODByMUGg{txONg>? NEG1T289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[5OlgyLz5{N{[5OlgyRC:jPh?=
Ishikawa M2H2T2Z2dmO2aX;uJIF{e2G7 NULvWWVXS2:wY3XueJJifGmxbjDv[kBkd22yb4Xu[EBz\XG3aYLl[EB1dyCrbnT1Z4UhPTBiJTDv[kB1cGVibXH4bY12dSC|dHnteYxifGmxbjDv[kBidGujbHnu[UBxcG:|cHjheIF{\SCjY4Tpeol1gSCrbjDJd4hqc2G5YTDj[YxteyxiRVO1NEA:KDBwMEOzJO69VS5? MoPJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDJyMUW4O{c,QDJyMUW4O|ww[T5?
MCF-7 NEfxT2VHfW6ldHnvckBie3OjeR?= MVHF[oZm[3SrdnWgZ49v[2WwdILheIlwdiCjZ3HpcpN1KE2FRj23JIJz\WG|dDD0eY1weiClZXzsd{B2e2mwZzDNR2YuPyCjc4PhfU4tKEWFNUCgQUAxNjBzIN88UU4> NYiySIw4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK4NlU6OzVpPkGyPFI2QTN3PD;hQi=>
ScN2a-cl3 NIG3eGVHfW6ldHnvckBie3OjeR?= NF\GOHQ2KGSjeYO= MlHXTY5pcWKrdHnvckBw\iCUTVygdJJqd25icILveIVqdiCrbn\lZ5Rm\CCrbjDtc5V{\SCmaY\p[Ilv\yCVY16yZU1kdDNiY3XscJMh\XiycnXzd4lv\yCodXzsJIxmdme2aDDtc5V{\SCScmCgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIGDyVJNkKGyndnXsJIFnfGW{IEWg[IF6eyCkeTDFUGlUSSxiRVO1NEA:KDRwM{mg{txONg>? MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF6M{W4PUc,OjRzOEO1PFk9N2F-
NCI-H460 M4XTeWFvfGmlYX7j[ZIh[XO|YYm= MX2yOEBpenN? MXfBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg1PjBiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JHNTSiCjc4PhfUwhT0l3MDC9JFQvPDhizszNMi=> MmrXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5M{OwPFUoRjF7N{OzNFg2RC:jPh?=
DU145 MnrERY51cWOjbnPldkBie3OjeR?= M1;adlI1KGi{cx?= NUnrXWQ1SW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGGodHXyJFI1KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUA3NjB5IN88UU4> MoHxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5M{OwPFUoRjF7N{OzNFg2RC:jPh?=
SKOV3 MorwRY51cWOjbnPldkBie3OjeR?= NIHZbFgzPCCqcoO= MXPBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1vPWlMh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IGPSRkBie3OjeTygS2k2OCB;IE[uOEDPxE1w MlHBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5M{OwPFUoRjF7N{OzNFg2RC:jPh?=
MCF7 MVHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MXe0PEBpenN? NEKxeXZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOg[ZhxemW|c3nu[{Bme3S{b3flckBz\WOncITvdkBqdmO3YnH0[YQhf2m2aDCwMlAxOyCwTTDv[kBme3S{YXTpc4wh[W6mIECuNFEhdk1ib3[geIV{fG:|dHXyc45mKGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7IHnuJJBz\XOnbnPlJI9nKDVnIH\leIFtKGKxdnnu[UB{\XK3bTygS2k2OCB;IEKuNlkxQDdizszNMi=> MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTVzM{K3OUc,OjF3MUOyO|U9N2F-
MCF7 M4naUmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mn\COFghcHK| NXPYNVlqSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIV5eHKnc4Ppcoch\XO2cn;n[Y4hemWlZYD0c5IhcW6ldXLheIVlKHerdHigNE4xPiCwTTDv[kBme3S{YXTpc4wh[W6mIECuNFchdk1ib3[geIV{fG:|dHXyc45mKGGodHXyJFQ5KGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7IHnuJJBz\XOnbnPlJI9nKG[ndHHsJIJwfmmwZTDz[ZJ2dSCjbnSgUpVU\XK3bTygS2k2OCB;IEKuPVUyOjFizszNMi=> MnWwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3MUOyO|UoRjJzNUGzNlc2RC:jPh?=
MCF7 MXTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M2jZflQ5KGi{cx?= M4n2W2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDlfJBz\XO|aX7nJIV{fHKxZ3XuJJJm[2WydH;yJIlv[3WkYYTl[EB4cXSqIEGwNEBvVSCxZjDld5Rz[WSrb3ygZY5lKDBwMEegcm0hd2ZidHXzeI9{fGW{b37lJIFnfGW{IES4JIhzeyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6KGmwIIDy[ZNmdmOnIH;mJIZmfGGuIHLveolv\SC|ZYL1cUBidmRiToXT[ZJ2dSxiR1m1NEA:KDVwNkKzOFEh|ryPLh?= MmjQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3MUOyO|UoRjJzNUGzNlc2RC:jPh?=
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MCF7 M2LhTWN6fG:2b4jpZ4l1gSCjc4PhfS=> MWW0PEBpenN? NYP2NFdXS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTFwNESg{txONg>? NFnKSoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CyNlI5OSd-MkOwNlIzQDF:L3G+
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insect cells MWfGeY5kfGmxbjDhd5NigQ>? MlzGSIl{eGyjY3Xt[Y51KG:oIH\seY9z\XOlZXnuMYxi[mWuZXSg[ZN1emGmaX;sJEhndHWxcn;tc45mMSCocn;tJIh2dWGwIILlZ49u[mmwYX70JIZ2dGxvbHXu[5RpKHWwdHHn[4VlKGW|dILv[4VvKHKnY3XweI9zKGKndHGg[ZhxemW|c3XkJIlvKGmwc3XjeEBk\WyuczDifUBndHWxcnXzZ4Vv[2VicH;sZZJqgmG2aX;uJIF{e2G7LDDJR|UxKD1iMD6xPFgh|ryPLh?= NIrpPI89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OESyOlk{OSd-Mki0NlY6OzF:L3G+
Ishikawa MnfxSpVv[3Srb36gZZN{[Xl? M1K2UVczKGi{cx?= MV\BcpRi\2:waYP0JIFkfGm4aYT5JIF1KGW|dILv[4VvKHKnY3XweI9zKGGucHjhM4JmfGFiaX6gbJVu[W5iSYPobYtif2FiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFtc2GuaX7lJJBpd3OyaHH0ZZNmKGG|c3H5MEBKSzVyIE2gNE4zQCEQvF2u NVXqdHU1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0NlY6OzFpPkK4OFI3QTNzPD;hQi=>
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Ishikawa MnXDRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NWPFVGxHPDhiaILz MkTpRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCLc3jpb4F4[SClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVYvPDdizszNMi=> NWPyTng{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0OlA5OTlpPkK4OFYxQDF7PD;hQi=>
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Ishikawa M2nUeWN6fG:2b4jpZ4l1gSCjc4PhfS=> NFfGTHpEgXSxdH;4bYNqfHliaX6gbJVu[W5iSYPobYtif2FiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCrbnP1ZoF1\WRiZn;yJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOC54NTFOwG0v MmHNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7NEKxNVMoRjJ6OUSyNVE{RC:jPh?=
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MCF7 MlXsSpVv[3Srb36gZZN{[Xl? MlHGOlAhdWdxa3e= M4DiN|Uh\GG7czDw[ZIhf2WnazDmc5IhPDhiZHH5dy=> MUnEc5dvemWpdXzheIlwdiCxZjDwdo9o\XO2ZYLvcoUhemWlZYD0c5IhdVKQQTDs[ZZmdCCrbjDOU2QhW0OLRDDnZY1u[SCvb4Xz[UB5\W6xZ4Lh[pRm\CC5aYToJIh2dWGwIF3DSlch[2WubIOgZZQhPjBibXevb4ctKHCxIEWg[IF6eyCyZYKge4VmcyCob4KgOFgh\GG7czDwc5N1KHS3bX;yJIlueGyjboTheIlwdiCvZXHzeZJm\CB5IHjyd{Bxd3O2IHzhd5Qh\G:|ZTDifUBTXC2SQ2KgcYV1cG:m MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV4MkezO{c,Ojl3NkK3N|c9N2F-
MCF7 MnLlRY51cXS3bX;yJIF{e2G7 MkPiOlAhdWdxa3e= M4jUTFQhf2Wna4O= M4TnfGFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgfIVvd2e{YX\0[YQhcW5iboWvcpUhdW:3c3WgcY9l\Wxib3[geIFud3irZnXuMZNmdnOrdHn2[UBjemWjc4SgZ4Fv[2W{IIjlco9oemGodDDpcZBt[W62ZXSge4l1cCBzN3LleIEu\XO2cnHkbY9tKHSrbXWgdoVt\WG|ZTDw[Yxt\XS|IHHzd4V{e2WmIHHzJJJm\HWldHnvckB1fW2xcjD2c4x2dWViYYSgOlAhdWdxa3esJJBwKHGmIH\vdkA1KHenZXvz Mnj4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOE[2NlYoRjNyMEi2OlI3RC:jPh?=
insect cells MWDGeY5kfGmxbjDhd5NigQ>? NUXQbmY2OC5zIITvJFExODByIIXN MmXGRolv\GmwZzDh[oZqdmm2eTD0c{B2dnSjZ3fl[EBpfW2jbjDy[YNwdWKrbnHueEBnfWyuIHzlcod1cCCHUnHsdIhiKGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMhOC5zIITvJFExODByIIXNJIJ6KE[udX;ycY9v\SCHU{KgS5Jm\W5iZHnzdIxi[2WvZX70JIJie2WmIHHzd4F6 MkewQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOUG5NlAoRjNyMEmxPVIxRC:jPh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT; 

PubMed: 30759864     


MCF-7 cells were treated with 2 μM tamoxifen and harvested at the indicated time point to analyze the expressions of p-AKT and AKT by western blot.

ER-α66 / ER-α36 / HER2 / EGFR; 

PubMed: 25203051     


Western blot analysis of the expression levels of ER-α66, ER-α36, HER2 and EGFR in ER-positive breast cancer MCF7 (A), T47D (B) and H3396 (C) cells treated with 1 µM of tamoxifen (TAM) for indicated time period.

p-AMPK / AMPK / p-ACC / ACC / p-P70S6K / p-S6 / p-4EBP1; 

PubMed: 27020861     


B. Immunoblot of AMPK pathway activation following treatment with 30μM tamoxifen in MCF7 and C. in MDA-MB-231 cells. 

CD36 / p-ERK / ERK ; 

PubMed: 30573731     


MCF-7 cells MCF-7 cells were treated with tamoxifen (Tam) at the indicated concentrations for 16 h, or with 5 μM Tam for the indicated times. Expression of CD36, p-ERK1/2 and ERK1/2 was determined by western blot.

30759864 25203051 27020861 30573731
Immunofluorescence
CD36; 

PubMed: 30573731     


MCF-7 cells were treated with tamoxifen (Tam) at the indicated concentrations for 16 h. Expression of CD36 was determined by immunofluorescent staining. 

30573731
体内研究

Tamoxifen (TAM)被广泛用于乳腺癌的治疗和防治。但是它在人类子宫和大鼠肝脏中具有致癌性[2]。TAM诱导性Cre-loxP系统在研究领域中广泛被运用,在研究组织发育、稳态和功能中发挥了重要作用。TAM所诱导的Cre重组酶核定位是时间依赖性和浓度依赖性的。高浓度的TAM可在给药后几周持续诱导重组,而低浓度的TAM在给药后的效果也能持续长达一周。TAM诱导的基因重组的持续时间也是浓度依赖性的,高浓度的TAM可导致更多的Cre-ER核定位。在TAM诱导性模型中,TAM也会具有一些副作用,带来生理影响[4]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[2]

- 合并
  • Cell lines: MCF7、T47D
  • Concentrations: 10-6 mol/L
  • Incubation Time: 24, 48 和 96 h
  • Method:

    在加入E2和TAM前48小时,用5 mL PBS洗涤细胞,并将细胞置于无酚红的含10%活性炭处理过的FBS的RPMI-1640培养基中培养。将E2和TAM溶于乙醇中,用培养基进行稀释,使其浓度分别为10-8 mol/L和10-6 mol/L,加入细胞培养基中进行孵育,孵育24、48、96小时。


    (Only for Reference)
动物实验:

[4]

- 合并
  • Animal Models: Pdx1PB-CreERTm mice
  • Dosages: --
  • Administration: s.c.
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 74 mg/mL (199.18 mM)
Water Insoluble
Ethanol '''74 mg/mL
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
1mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 371.51
化学式

C26H29NO

CAS号 10540-29-1
储存条件 粉状
溶于溶剂
别名 (Z)-Tamoxifen, trans-Tamoxifen

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04200066 Not yet recruiting Drug: Temozolomide Tamoxifen Maprotiline Glioblastoma|Brain Tumor University of Rochester May 1 2021 Phase 1
NCT04433494 Not yet recruiting Drug: TY-302: capsule 25mg/50mg ; Tamoxifen: tablet10mg Breast Cancer|Solid Tumor TYK Medicines Inc October 2020 Phase 1
NCT04174352 Recruiting Drug: Tamoxifen|Diagnostic Test: FES PET/CT ERα+ Breast Cancer|ESR1 Gene Mutation University of Wisconsin Madison October 20 2020 Early Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    Could you tell me if you have a protocol for the use of tamoxifen (S1238) in vivo in mouse? Is there an administration way that is better than another?

  • 回答:

    Tamoxifen (S1238) can be dissolved in 10% ethanol/10% Tween 80/ddH2O at 5 mg/ml clearly. But precipitation will form if the formulation was left at RT for an hour or longer. So we'd suggest that you use it quickly after formulation. Tamoxifen is often administrated via i.p injection.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID