Progesterone (NSC 9704)

For research use only. Not for use in humans.

目录号:S1705 别名: NSC 64377, Pregn-4-ene-3,20-dione 中文名称:黄体酮

Progesterone (NSC 9704) Chemical Structure

CAS No. 57-83-0

Progesterone (NSC 9704, NSC 64377, Pregn-4-ene-3,20-dione)是一种内源性的甾类激素,参与调节月经周期、怀孕、人类和其他物种的胚胎发育过程。是有效的nuclear progesterone receptor (nPR)激动剂,Kd值为1 nM;membrane progesterone receptors(mPRs)的激动剂、σ1 receptor的拮抗剂。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1061.65 现货
RMB 811.92 现货
RMB 1388.33 现货
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客户使用Selleck生产的Progesterone (NSC 9704)发表文献8篇:

客户使用该产品的2个实验数据:

  • Metformin alleviated EP-induced decidualization of endometrial stromal cells. (A–D) Endometrial stromal cells were treated with or without estradiol (10 nM) and progesterone (1 μM) in the absence or presence of metformin (1 mM) for 10 days or 14 days. Then, mRNA levels of IGFBP-1 and prolactin in endometrial stromal cells were examined by RT-qPCR assay (A and B). Secreted protein levels of IGFBP-1 and prolactin into media were tested by matching ELISA kits (C and D). #* P < 0.05.

    Biomed Pharmacother, 2019, 109:1578-1585. Progesterone (NSC 9704) purchased from Selleck.

    SPOP inhibits progesterone-induced S phase entry and Erk1/2 activation. (A) T47D cells were transfected with control or Myc-SPOP constructs. After 24 hr, cells were treated with the vehicle ethanol (EtOH) or progesterone (10 nM) for 24 hr. The cell cycle percentages was determined by PI staining and FACS; (B) T47D cells were transfected with control siRNAs or SPOP-specific siRNAs. After 48 hr, cells were treated and analyzed as in (A); (C) T47D cells were transfected with control or Myc-SPOP constructs. After 24 hr, cells were treated with the vehicle ethanol (EtOH) or progesterone (10 nM) for indicated times. Cell lysates were prepared for WB analyses; (D) T47D cells were transfected with control or SPOP-specific siRNA. After 48 hr, cells were treated and analyzed as in (C).

    Am J Cancer Res, 2015, 5(10): 3210-3220.. Progesterone (NSC 9704) purchased from Selleck.

产品安全说明书

Estrogen/progestogen Receptor抑制剂选择性比较

生物活性

产品描述 Progesterone (NSC 9704, NSC 64377, Pregn-4-ene-3,20-dione)是一种内源性的甾类激素,参与调节月经周期、怀孕、人类和其他物种的胚胎发育过程。是有效的nuclear progesterone receptor (nPR)激动剂,Kd值为1 nM;membrane progesterone receptors(mPRs)的激动剂、σ1 receptor的拮抗剂。
靶点
progestogen Receptor [1]
体外研究

Progesterone对乳腺癌细胞增殖的双相效应;它刺激第一细胞周期的生长,然后阻断细胞停留在G1/S期。伴随着细胞周期蛋白p21依赖性的上调。Progesterone介导的转录为过表达的E1A所阻断,这表明CBP/p300的是必需的。[1]  Progesterone驱动一系列活动,其中管腔细胞可能提供基底细胞Wnt4和RANKL信号,反过来通过上调同源受体,转录目标和细胞周期的标志回应。[2] Progesterone增加皮质synaptoneurosomes对GABA的敏感性(即,减少的EC 50),并增加GABA刺激氯离子转运(即增加了的Emax)最大效力。 [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human T47D cells NF\US2dHfW6ldHnvckBie3OjeR?= M2[5TlIxKGh? Ml3oRYN1cX[jdHnvckBw\iCycn;n[ZN1\XKxbnWgdoVk\XC2b4KgbY4hcHWvYX6gWFQ4TCClZXzsd{Bi\nSncjCyNEBpenNiYomgVHJGNXSjZ3fl[EBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5zIH7N MUOxPVg3OzB6Mx?=
CV-1 cells NEC4e3lHfW6ldHnvckBie3OjeR?= MWrF[oZm[3SrdnWgZ49v[2WwdILheIlwdiCob4KgbIFt\i2vYYjpcYFtKGGldHn2ZZRqd25ib3[gbJVu[W5icILv[4V{fGW{b37lJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCFVj2xJINmdGy|LDDFR|UxRTFwNTDuUS=> MojmPVY3Pzl4OB?=
HEK293 cells MUHGeY5kfGmxbjDhd5NigQ>? NYjYXFBxSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBRWkeUIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVIhdk1? NIr1UHQzPTNyNU[4PC=>
SF-12 cells M37tU2Z2dmO2aX;uJIF{e2G7 MYDEbZNxdGGlZX3lcpQhd2ZiRFjUJIZzd21iaIXtZY4h[W6mcn;n[Y4hemWlZYD0c5Ih\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJHNHNTF{IHPlcIx{NCCNaU25MlUhdk1? MonpNVI6PTRyNkK=
CHO cells NVz2[ZRJTnWwY4Tpc44h[XO|YYm= NXG5PZlFSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBVT1J3IHX4dJJme3OnZDDpckBEUE9iY3XscJMh[nlibIXjbYZmemG|ZTDhd5NigSxiRVO1NF0zNjd5IN88US=> MoP2NVg{ODd{OUS=
human K562/R7 cells MoDESpVv[3Srb36gZZN{[Xl? NIPHUYUyKM7:TR?= Ml;OO|IhcA>? MlTEVI91\W62aXH0bY9vKG:oIHTvfI9zfWKrY3nuMYlv\HWlZXSgZ5l1d3SxeHnjbZR6KGGpYXnud5Qh\G:6b4L1ZolkcW5vcnXzbZN1[W62IHj1cYFvKEt3NkKvVlch[2WubIOgZZN{\XO|ZXSgZZMh\G:6b4L1ZolkcW5iSVO1NEBifCBzIIXNJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MUCuOkDPxE1? M2\0clI2PjN2MESx
A2780 cells MUTGeY5kfGmxbjDhd5NigQ>? M4PpPWlvcGmkaYTpc44hd2ZiUD3ndEBqdiCqdX3hckBi\HKrYX35Z4lvNXKnc3nzeIFvfCCDMke4NEBk\WyuczDifUBJd2WlaIP0JFM{OzR{IHHzd4F6NCCLQ{WwQVQ4Njh4MzFOwG0> M17UPFE5Pjd6NEm1
HeLa cells MVjDfZRwfG:6aXPpeJkh[XO|YYm= NYLveoRyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKESQQTDy[ZBtcWOjdHnvckBjgSCrbXHnbY5oKGGwYXz5d4l{ NG\LVGcyQDB4NkC1OS=>

... Click to View More Cell Line Experimental Data

体内研究 在雌性3xTg-AD小鼠中,Progesterone阻断对Abeta积累的有益效果,但不影响行为表现。Progesterone当两个单独或与雌激素联合给药时和孕酮联用显著降低tau蛋白磷酸化。[4] Progesterone处理的老鼠在Morris水迷宫空间导航的任务比对照大鼠受损较小。Progesterone处理的大鼠在背内侧丘脑核结构损伤21天后显示较少的神经元变性,具有与挫伤区域相互连接。sup>[5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 22 mg/mL (69.96 mM)
Water Insoluble
Ethanol ''63 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 314.46
化学式

C21H30O2

CAS号 57-83-0
储存条件 粉状
溶于溶剂
别名 NSC 64377, Pregn-4-ene-3,20-dione

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05109676 Recruiting Other: Questionnaire IVF University Hospital Toulouse January 2022 Not Applicable
NCT04939064 Recruiting -- Normal Endometrial Physiology Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) January 18 2022 --
NCT04499131 Recruiting Drug: Progesterone|Other: Artificial Cycle (no intervention) Infertility Female|ENDOMETRIAL RECEPTIVITY Instituto Valenciano de Infertilidad IVI VALENCIA December 9 2021 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID