SB203580

For research use only. Not for use in humans.

目录号:S1076 别名: RWJ 64809, PB 203580

SB203580 Chemical Structure

CAS No. 152121-47-6

SB203580 (RWJ 64809, PB 203580) 是一种p38 MAPK抑制剂,在THP-1细胞中IC50为0.3-0.5 μM,对SAPK3(106T)和SAPK4(106T)选择性低10倍,且阻断PKB磷酸化,IC50为3-5 μM。SB203580 可诱导线粒体自噬和细胞自噬。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1565.11 现货
RMB 1195.54 现货
RMB 2193.43 现货
RMB 3864.74 现货
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客户使用Selleck生产的SB203580发表文献664篇:

产品安全说明书

p38 MAPK抑制剂选择性比较

生物活性

产品描述 SB203580 (RWJ 64809, PB 203580) 是一种p38 MAPK抑制剂,在THP-1细胞中IC50为0.3-0.5 μM,对SAPK3(106T)和SAPK4(106T)选择性低10倍,且阻断PKB磷酸化,IC50为3-5 μM。SB203580 可诱导线粒体自噬和细胞自噬。
特性 SB203580是第一个被报道的p38抑制剂。
靶点
p38 MAPK [1]
(THP-1 cells)
PKB [1]
(THP-1 cells)
0.3 μM-0.5 μM 3 μM-5 μM
体外研究

SB203580作用于人类T细胞,鼠CT6 T细胞, 或BAF F7 B细胞,抑制IL-2诱导的增殖,IC50为3-5 μM。SB203580也抑制IL-2诱导的p70S6K激活, IC50 > 10 μM。SB203580也抑制PDK1活性,IC50为3-10 μM,这种抑制存在剂量依赖性。[1]SB203580抑制MAPKAPK2中p38-MAPK的刺激,IC50 为0.07 μM, 然而抑制完整SAPK/JNK活性时,IC50为3-10 μM。SB203580 高浓度时激活ERK通路,随后增强NF-κB转录活性。[2]SB203580作用于人类肝癌细胞(HCC),诱导自体吞噬。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PC12 Mn;pT4lv[XOnIFHzd4F6 NH65SlQyOCEQvF2= NXLpc5MyOTVibXnu MWjJcohq[mm2czDwN|ghVUGSIHvpcoF{\SC5aYToJGlEPTBib3[gNE43KM7:TR?= NWjmbIZIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxN{e1NFU4Pyd-N{e1NFU4PzxxYU6=
THP-1 M1:zR2Z2dmO2aX;uJGF{e2G7 NWHOdHBnUW6qaXLpeJMhVFCVLXnu[JVk\WRiVF7GZYxxcGFicILv[JVkfGmxbjD3bZRpKEmFNUCgc4YhOC5zNjFOwG0> MoX2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh|MkW3OlgoRjF6M{K1O|Y5RC:jPh?=
PBMC NIDUbJBHfW6ldHnvckBCe3OjeR?= M3;wWVE2KG2rbh?= MknaSG1UVw>? MormTY5pcWKrdIOgeIhmKHKnbHXhd4Uhd2ZiaX70[ZJt\XWtaX6tNU1j\XSjIIfpeIghUUN3MDDv[kAxNjB|NzFOwG0> Mli2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ|NkGzPVYoRjF{M{[xN|k3RC:jPh?=
SW1353 MX3GeY5kfGmxbjDBd5NigQ>? M12yZVEhcA>? M4nic2ROW09? M1rQUGlvcGmkaYTzJGlNNTZicILv[JVkfGmxbjD3bZRpKEmFNUCgc4YhOC5yNTFOwG0> MoLCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFzNEC3OFEoRjFzMUSwO|QyRC:jPh?=
Hela NHzESnFHfW6ldHnvckBCe3OjeR?= MoPGSG1UVw>? M3m4dmlvcGmkaYTzJHRifC2rbnT1Z4VlKEiLVkGgUHRTKHS{YX7zZYN1cX[jdHnvckBqdiCqdX3hckBJ\UyjIHPlcIx{KHerdHigTWM2OCCxZjCwMlEh|ryP NIfTPWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEmyOlcyOSd-MUi5NlY4OTF:L3G+
PC12 M3rXUmZ2dmO2aX;uJGF{e2G7 MX:xNEDPxE1? MkLTSG1UVw>? NFPRc4FC[3SrdnH0[ZMhVnKoMj;BVmUhcW5icnH0JHBEOTJiY3XscJMh[XO|ZYPz[YQh[XNiSF:tNUBxem:2ZXnuJIlv\HWldHnvci=> NXXmSHV7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzOFU3QDVpPkKxN|Q2Pjh3PD;hQi=>
RAW 264.7 MWrDfZRwfG:6aXOgRZN{[Xl? NFjEWooyOi53IN88US=> NGrQeI8yOmh? NIjyNIxFVVOR M13OXGJtd2OtczDs[ZRp[WxidH;4bY4udWWmaXH0[YQh[3m2b4TvfIlkcXS7 M2T0e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEi1OVA1Lz5zN{S4OVUxPDxxYU6=
HCA2 M4TjVWZ2dmO2aX;uJGF{e2G7 NVL1WHEyOi53IN88US=> MoPBTY5pcWKrdIOgdFM5KG2nZHnheIVlKE2NMjDhZ5RqfmG2aX;u MoPKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7NkS3PFAoRjF5OU[0O|gxRC:jPh?=
U937 M4P2[GZ2dmO2aX;uJGF{e2G7 NImwZm9KdmirYnn0d{BLSUtvbXXkbYF1\WRiaX70[ZJn\XKxbj3nZY1u[S:jbnnzc416[2mwLXnu[JVk\WRiU4TheFEheGixc4Doc5J6dGG2aX;u NXH0OmZbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUixOVcyOjJpPkG4NVU4OTJ{PD;hQi=>
U937 M2LU[mZ2dmO2aX;uJGF{e2G7 NFrNNW5KdmirYnn0d{BLSUtvbXXkbYF1\WRiaX70[ZJn\XKxbj3nZY1u[S:jbnnzc416[2mwLXnu[JVk\WRicEO4JJBpd3OyaH;yfYxifGmxbh?= NGLxeZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEG1O|EzOid-MUixOVcyOjJ:L3G+
hESCs NYK5OFl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYK1JO69VQ>? NXz2UFlUTE2VTx?= NHTINJRKdmS3Y3XzJINiemSrb335c4dmdmmlIHHjeIl3cXS7IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5Rp MlHlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MEKzPVkoRjJ|NkCyN|k6RC:jPh?=
RAW264.7 M4jOTmZ2dmO2aX;uJGF{e2G7 MoXzNVAh|ryP NIPWNW9KdmS3Y3XzJIFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgZpkhcW6qaXLpeIlv\yCLTD2x{tIhemWuZXHz[S=> MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd7MUC3PEc,OjN5OUGwO|g9N2F-
RAW264.7 NW\GRmd3TnWwY4Tpc44hSXO|YYm= NWTxOGhJOTBizszN MVLJcoR2[2W|IHHueIlqdm[uYX3tZZRwenliYXP0bZZqfHliYomgbY5pcWKrdHnu[{BqVk:VIILlcIVie2V? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd7MUC3PEc,OjN5OUGwO|g9N2F-
RAW264.7 NYjTVFdGTnWwY4Tpc44hSXO|YYm= Moi4NVAh|ryP NUPTUGw3UW6mdXPld{BidnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIJ6KGmwaHnibZRqdmdiTl:gdoVt\WG|ZR?= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd7MUC3PEc,OjN5OUGwO|g9N2F-
RAW264.7 MnLiSpVv[3Srb36gRZN{[Xl? M3XieVExKM7:TR?= MoX2TY5pcWKrdIOgUHBUNWmwZIXj[YQheDN6IF3BVGsheGixc4Doc5J6dGG2aX;u NIrCUFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECxOlA2Pyd-MkSwNVYxPTd:L3G+
IEC-18 NGSyUlRHfW6ldHnvckBCe3OjeR?= NVXETmk4OTBizszN NWP6V4tWUW6qaXLpeJMhVFCVLXnu[JVk\WRicEO4JG1CWEticHjvd5Bpd3K7bHH0bY9v M{CyWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{W4NVExLz5{M{e1PFEyODxxYU6=
Sf9 M3LDOmZ2dmO2aX;uJIF{e2G7 NUPRcJNGOzBibXnudy=> MkDtTY5pcWKrdHnvckBw\iCodXzsMYxmdme2aDDGUGFINT[KaYOtWGVXKHSjZ3fl[EBpfW2jbjDSTXAzKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHH1eI9xcG:|cHjvdplt[XSrb36gdJJmNWmwY4XiZZRm\CCob4KgN|AhdWmwczDmc4xtd3enZDDifUBqdmO3YnH0bY9vKHerdHigRXRRKG[xcjCyJIhzeyCkeTDBSHAuT2yxIHHzd4F6NCCLQ{WwJF0hOC5yMTFOwG0v MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjR3NU[1OEc,OjZ2NUW2OVQ9N2F-
sf21 MnrBSpVv[3Srb36gZZN{[Xl? MmG2Rolv\GmwZzDh[oZqdmm2eTD0c{B4cWymIIT5dIUhcHWvYX6gZolwfGmwIHzhZoVtdGWmIICzPEBidHCqYTCoPUB1dyB|NUKgdoV{cWS3ZYOpJIV5eHKnc4Pl[EBqdiC|ZkKxJIlve2WldDDj[YxteyCVUGKgZY5idHm|aYOsJGtlKD1iMD6wNlE4KM7:TT6= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh|NESzNUc,Ojh6M{S0N|E9N2F-
PBMC M4[5O2Z2dmO2aX;uJIF{e2G7 NU\wdIk5UW6qaXLpeIlwdiCxZjDUUmYu[WyyaHGgdJJw\HWldHnvckBjgSCuaYDvdI9tgXOjY3PoZZJq\GVvc4TpcZVt[XSnZDDoeY1idiCyZYLpdIhmemGuIHLsc49lKG2xbn;ueYNt\WG{IHPlcIx{NCCLQ{WwJF0hOC5yMkWg{txONg>? NGPReoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97OEezO|MxLz57OEezO|MxRC:jPh?=
PBMC NXfuU|J2TnWwY4Tpc44h[XO|YYm= NHvoSlRKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKFSKK17GMYFteGi|IIDyc4R2[3Srb36gZpkhcHWvYX6gdIVzcXCqZYLhcEBjdG:xZDDtc45wdnWlbHXhdkBk\WyuczCoVGJOS3NrLDDJR|UxKD1iMD6wNlUh|ryPLh?= NHPNelc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97N{i0NFk{Lz57N{i0NFk{RC:jPh?=
PBMC M2Xt[WZ2dmO2aX;uJIF{e2G7 NXH6SllWUW6qaXLpeIlwdiCxZjDwN|ghVUGSIHvpcoF{\SC{ZXzheIVlKFSQRj3hcJBp[SC{ZXzlZZNmKG[{b32gdIVzcXCqZYLhcEBjdG:xZDDtc45wdnWlbHXhdkBk\WyuczCoVGJOSyluIFnDOVAhRSByLkCzO{DPxE1w MmLrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJyNkG4O|YoRjF{ME[xPFc3RC:jPh?=
PBMC NILxepNHfW6ldHnvckBie3OjeR?= M3LKOmlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgTWwyNWKndHGgdJJw\HWldHnvckBqdiCqdX3hckBx\XKrcHjldoFtKGKub3;kJI1wdm:wdXPs[YFzKGOnbHzzLHBDVUO|KTygTWM2OCB;IECuNFQ5KM7:TT6= MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86Pzh2MEmzK|46Pzh2MEmzQE9iRg>?
SW1353 MVzGeY5kfGmxbjDhd5NigQ>? NHjMOoVEd22yb4Xu[EB4[XNiZY\hcJVifGWmIH\vdkBqfHNiYXLpcIl1gSC2bzDpcohq[mm2IFnMMVYheHKxZIXjeIlwdiCrbjDTW|E{PTNiY3XscJMhfHKnYYTl[EB4cXSqIHP5eI9scW6nczDJUE0yKGGwZDDUUmYtKEmFNUCgQUAxNjB3IN88UU4> MkHxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB7OUm0OlcoRjFyOUm5OFY4RC:jPh?=
SW1353 NUfDOVZRTnWwY4Tpc44h[XO|YYm= Mn7vTY5pcWKrdHnvckBw\iCWTl[gZY5lKEmOLUGgbY5lfWOnZDDJUE03KHC{b3T1Z5Rqd25iaX6gbJVu[W5iY3jvcoRzdy2|YYLjc41iKFOZIEGzOVMh[2WubIOsJGlEPTBiPTCwMlA2KM7:TT6= NFLQT209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEm5PVQ3QCd-MUC5PVk1Pjh:L3G+
THP1 NEDJSXVHfW6ldHnvckBie3OjeR?= M3vCZWlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhUUxzIIDyc4R2[3Srb36gbY4hcHWvYX6gWGhROSClZXzsd{whUUN3MDC9JFAvODVizszNMi=> NITQNIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEC3O|M3Oyd-MUiwO|c{PjN:L3G+
THP1 M{K3OWZ2dmO2aX;uJIF{e2G7 M1fMdWlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhXE6IYXzwbIEheHKxZIXjeIlwdiCrbjDoeY1idiCWSGCxJINmdGy|LDDJR|UxKD1iMD6wOUDPxE1w NH3scWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEC3O|M3Oyd-MUiwO|c{PjN:L3G+
THP1 MlntSpVv[3Srb36gZZN{[Xl? MXzJcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIIT1cY9zKG6nY4Lvd4l{KG[jY4Tvdk1idHCqYTCoWG5HNWGucHjhLUBxem:mdXP0bY9vKGmwIGTIVE0yKGOnbHzzMEBGSzVyIE2gNE4xPiEQvF2u NGfpVIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkC4OlQ5PSd-MUKwPFY1QDV:L3G+
THP1 Mne0SpVv[3Srb36gZZN{[Xl? MnnETY5pcWKrdHnvckBw\iC2dX3vdkBv\WO{b4Ppd{Bn[WO2b4KgZYxxcGFicnXs[YF{\SCkeTDUTHAuOSClZXzsd{whUUN3MDC9JFAvODdizszNMi=> MoHCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV4NUi4OVUoRjF3NkW4PFU2RC:jPh?=
monocytic cell NEf6TZpHfW6ldHnvckBie3OjeR?= M{DOVmlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBVVkZvYXzwbIEheHKxZIXjeIlwdiC3c3nu[{BtcXCxcH;sfZNi[2OqYYLp[IUhe3SrbYXsZZRm\CCqdX3hckBud26xY4n0bYMh[2WubIOsJGlEPTBiPTCwMlA4OiEQvF2u MonvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ5Mkm2N|coRjF{N{K5OlM4RC:jPh?=
THP1 M1f3dWZ2dmO2aX;uJIF{e2G7 NFLxT3hKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhVFCVLYP0bY12dGG2ZXSgWG5HNWGucHjhJJBzd2S3Y4Tpc44hcW5iaIXtZY4hdW:wb3P5eIlkKGOnbHzzJEhVUFBvMTmsJGlEPTBiPTCwMlA4OiEQvF2u MmTiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVzM{m3OFkoRjF3MUO5O|Q6RC:jPh?=
THP-1 MUHGeY5kfGmxbjDhd5NigQ>? M4DudWlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBtcXCxcH;sfZNi[2OqYYLp[IUhe3SrbYXsZZRm\CCWTl[tZYxxcGFicILv[JVkfGmxbjDpckBVUFBvMTDj[YxteyBqaIXtZY4hdW:wb3P5eIlkKGOnbHzzLUwhUUN3MDC9JFAvODd{IN88UU4> MojZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV6M{ezNVAoRjF3OEO3N|ExRC:jPh?=
THP1 NUnYR3BbTnWwY4Tpc44h[XO|YYm= NHvmc4JKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKFSQRnHsdIhiKHC{b3T1Z5Rqd25iaX6gWGhROSClZXzsd{whUUN3MDC9JFAvODd{IN88UU4> M3vYXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4N{WwN|Y4Lz5zNke1NFM3PzxxYU6=
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PBMC MnvuSpVv[3Srb36gZZN{[Xl? NHe1eWxEd26lZX70doF1cW:wIILldZVqemWmIITvJIlvcGmkaYSgcIlxd3CxbInzZYNkcGG{aXTlJIlv\HWlZXSgWG5HNWGucHjhJJJmdGWjc3Wge4F{KGSndHXycYlv\WRiaX6gbJVu[W5icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjDj[YxteyxiSVO1NEA:KDBwMUmg{txONg>? NET4NZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUS1OFI{OSd-MUW0OVQzOzF:L3G+
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HEK-293 MmG5SpVv[3Srb36gZZN{[Xl? MV3Jcohq[mm2aX;uJI9nKFKLUELLJIlvKE2GUD3zeIlufWyjdHXkJGhGUy1{OUOgZ4VtdHNib4\ldk1mgHC{ZYPzbY5oKE6RREKgZZN{\XO|ZXSgZZMhUUx6IIPlZ5JmfGmxbjygTWM2OCB;IECuNlUh|ryPLh?= NFvFTGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{GwPVg3Pyd-MkexNFk5Pjd:L3G+
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PBMC MoTXSpVv[3Srb36gZZN{[Xl? NH7SNm5KdmirYnn0bY9vKG:oIICzPEBOSVBia3nuZZNmKHKnbHH0[YQhXE6ILXHsdIhiKHKnbHXhd4Uh\nKxbTDw[ZJqeGincnHsJIJtd2:mIH3vco9vfWOuZXHyJINmdGy|IDjQRm1EMSxiSVO1NEA:KDBwNUmg{txONg>? NXiwXXNoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKwOlE5PzZpPkGyNFYyQDd4PD;hQi=>
PBMC M3PVTGZ2dmO2aX;uJIF{e2G7 MWrJcohq[mm2aX;uJI9nKHSqZTDy[Yxm[XOnIH;mJJR2dW:{IH7lZ5Jwe2m|IH\hZ5RweiCjbIDoZUBnem:vIIDldolxcGW{YXygZoxwd2RibX;uc452[2ynYYKgZ4VtdHNuIFnDOVAhRSByLkW5JO69VS5? MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjN4MUO5Okc,OTJ|NkGzPVY9N2F-
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