SB203580

For research use only. Not for use in humans.

目录号：S1076 别名： RWJ 64809, PB 203580

CAS No. 152121-47-6

SB203580 (RWJ 64809, PB 203580) 是一种p38 MAPK抑制剂，在THP-1细胞中IC50为0.3-0.5 μM，对SAPK3(106T)和SAPK4(106T)选择性低10倍，且阻断PKB磷酸化，IC50为3-5 μM。SB203580 可诱导线粒体自噬和细胞自噬。

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10mM (1mL in DMSO)	RMB 1565.11	现货
25mg	RMB 1195.54	现货
50mg	RMB 2193.43	现货
200mg	RMB 3864.74	现货
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客户使用Selleck生产的SB203580发表文献581篇：

Cell, 2020, 182(3):685-712.e19

PubMed: 32645325 ( click the link to review the publication )

Cell Metab, 2020, 4;31(2):406-421 e7

PubMed: 31839486 ( click the link to review the publication )

Nat Immunol, 2018, 19(3):233-245

PubMed: 29358709 ( click the link to review the publication )

Nat Methods, 2014, 11(8):855-60

PubMed: 24930130 ( click the link to review the publication )

Nat Chem Biol, 2013, 9(7):428-36

PubMed: 23685672 ( click the link to review the publication )

Food Chem, 2021, 348:129111

PubMed: 33516994 ( click the link to review the publication )

Stem Cell Res Ther, 2021, 12(1):50

PubMed: 33422134 ( click the link to review the publication )

Ecotoxicol Environ Saf, 2021, 208:111693

PubMed: 33396024 ( click the link to review the publication )

Apoptosis, 2021, 1007/s10495-020-01650-0

PubMed: 33387145 ( click the link to review the publication )

Mol Med Rep, 2021, 23(1)9

PubMed: 33179097 ( click the link to review the publication )

J Cell Physiol, 2021, 236(2):1375-1390

PubMed: 33128793 ( click the link to review the publication )

Nat Commun, 2020, 11(1):37

PubMed: 31896747 ( click the link to review the publication )

Nat Commun, 2020, 8;11(1):2286

PubMed: 32385332 ( click the link to review the publication )

EMBO Rep, 2020, 9:e49234

PubMed: 32270908 ( click the link to review the publication )

Theranostics, 2020, 10(24):11013-11025

PubMed: 33042267 ( click the link to review the publication )

Theranostics, 2020, 16;10(14):6448-6466

PubMed: 32483463 ( click the link to review the publication )

Cancer Res, 2020, 9 pii: canres

PubMed: 32273282 ( click the link to review the publication )

Cancer Res, 2020, 80(17):3606-3619

PubMed: 32641409 ( click the link to review the publication )

Cell Rep, 2020, 5;31(5):107585

PubMed: 32375032 ( click the link to review the publication )

Cell Rep, 2020, 31(2):107514

PubMed: 32294432 ( click the link to review the publication )

Part Fibre Toxicol, 2020, 17(1):46

PubMed: 32948194 ( click the link to review the publication )

Redox Biol, 2020, 28:101445

PubMed: 32037305 ( click the link to review the publication )

Cancers (Basel), 2020, 10;12(6):E1516

PubMed: 32531927 ( click the link to review the publication )

Cancers (Basel), 2020, 12(10)E2798

PubMed: 33003486 ( click the link to review the publication )
Cancers (Basel), 2020, 12(11)E3216

PubMed: 33142778 ( click the link to review the publication )

Pigment Cell Melanoma Res, 2020, 10.1111/pcmr.12925

PubMed: 32910840 ( click the link to review the publication )

Cell Death Discov, 2020, 4;6:33

PubMed: 32377396 ( click the link to review the publication )

Glia, 2020, 68(1):27-43

PubMed: 31429156 ( click the link to review the publication )

J Clin Endocrinol Metab, 2020, 10.1210/clinem/dgaa096

PubMed: 32119078 ( click the link to review the publication )

Cells, 2020, 13;9(5) pii: E1209

PubMed: 32414111 ( click the link to review the publication )

FASEB J, 2020, 10.1096/fj.202000657R

PubMed: 33124742 ( click the link to review the publication )

J Mol Cell Biol, 2020, 22;12(1):55-70

PubMed: 30986855 ( click the link to review the publication )

FASEB J, 2020, 10.1096/fj.202000186RRR

PubMed: 32918765 ( click the link to review the publication )

FASEB J, 2020, 22

PubMed: 32319705 ( click the link to review the publication )

FASEB J, 2020, 10.1096/fj.202001413R

PubMed: 32860638 ( click the link to review the publication )

Mol Cancer Ther, 2020, molcanther.0525.2020

PubMed: 33158997 ( click the link to review the publication )

Front Cell Dev Biol, 2020, 17;8:158

PubMed: 32258036 ( click the link to review the publication )

Front Cell Dev Biol, 2020, 8:853

PubMed: 32984338 ( click the link to review the publication )

Aging (Albany NY), 2020, 12(9):8167-8190

PubMed: 32365333 ( click the link to review the publication )

Oxid Med Cell Longev, 2020, 2020:5070415

PubMed: 33014270 ( click the link to review the publication )

Oxid Med Cell Longev, 2020, 2020:6096391

PubMed: 32879652 ( click the link to review the publication )

Cell Oncol (Dordr), 2020, 10.1007/s13402-020-00554-0

PubMed: 32910411 ( click the link to review the publication )

Am J Cancer Res, 2020, 10(1):148-163

PubMed: 32064158 ( click the link to review the publication )

Oncogenesis, 2020, 10;9(2):15

PubMed: 32041943 ( click the link to review the publication )

Biomolecules, 2020, 9;10(4) pii: E580

PubMed: 32283838 ( click the link to review the publication )

J Immunol, 2020, 20 pii: ji1901089

PubMed: 32312847 ( click the link to review the publication )

J Immunol, 2020, 205(8):2066-2076

PubMed: 32938730 ( click the link to review the publication )

Antioxidants (Basel), 2020, 9(3)

PubMed: 32150901 ( click the link to review the publication )
J Cell Physiol, 2020, 235(3):2911-2924

PubMed: 31535374 ( click the link to review the publication )

Antioxidants (Basel), 2020, 25;9(4):275

PubMed: 32218307 ( click the link to review the publication )

Chemosphere, 2020, 243:125336

PubMed: 31734597 ( click the link to review the publication )

Front Oncol, 2020, 10:582273

PubMed: 33194716 ( click the link to review the publication )

Lab Invest, 2020, 100(3):438-453

PubMed: 31641227 ( click the link to review the publication )

Neuropharmacology, 2020, 12;171:108084

PubMed: 32294462 ( click the link to review the publication )

Biochem Pharmacol, 2020, 30;177:114007

PubMed: 32360309 ( click the link to review the publication )

Toxicol Sci, 2020, kfaa159

PubMed: 33078829 ( click the link to review the publication )

Int J Mol Sci, 2020, 16;21(10):E3527

PubMed: 32429376 ( click the link to review the publication )

Sci Rep, 2020, 10(1):824

PubMed: 31965002 ( click the link to review the publication )

J Biol Chem, 2020, 295(3):673-689

PubMed: 31780563 ( click the link to review the publication )

RNA, 2020, 13 pii: rna 73528 119

PubMed: 32404348 ( click the link to review the publication )

Front Pharmacol, 2020, 11:554736

PubMed: 33013393 ( click the link to review the publication )

Front Pharmacol, 2020, 11:01055

PubMed: 33013353 ( click the link to review the publication )

Biomed Pharmacother, 2020, 23;128:110245

PubMed: 32454290 ( click the link to review the publication )

Biomed Pharmacother, 2020, 125:109702

PubMed: 32106383 ( click the link to review the publication )

Toxicol Appl Pharmacol, 2020, 388:114874

PubMed: 31881179 ( click the link to review the publication )

Mediators Inflamm, 2020, 23;2020:6420425

PubMed: 32273830 ( click the link to review the publication )

J Ethnopharmacol, 2020, 252:112612

PubMed: 31988015 ( click the link to review the publication )

J Agric Food Chem, 2020, 68(40):11229-11241

PubMed: 32940033 ( click the link to review the publication )

Virology, 2020, 539:121-128

PubMed: 31733451 ( click the link to review the publication )

Phytother Res, 2020, 10.1002/ptr.6892

PubMed: 33015893 ( click the link to review the publication )

Food Funct, 2020, 11(12):10968-10978

PubMed: 33283791 ( click the link to review the publication )

Int J Biochem Cell Biol, 2020, 121:105703

PubMed: 32014499 ( click the link to review the publication )
Fish Shellfish Immunol, 2020, 10.1016/j.fsi.2020.03.056

PubMed: 32224280 ( click the link to review the publication )

Endocrine, 2020, 67(3):587-596

PubMed: 31845180 ( click the link to review the publication )

Brain Res, 2020, 12:146881

PubMed: 32413357 ( click the link to review the publication )

Oncol Rep, 2020, 21

PubMed: 32468011 ( click the link to review the publication )

Eur J Pharmacol, 2020, 868:172886

PubMed: 31866407 ( click the link to review the publication )

Cell Immunol, 2020, 347:104027

PubMed: 31864664 ( click the link to review the publication )

Spine (Phila Pa 1976), 2020, 45(3):E126-E139

PubMed: 31464976 ( click the link to review the publication )

BMC Microbiol, 2020, 20(1):171

PubMed: 32560675 ( click the link to review the publication )

Environ Toxicol, 2020, 9

PubMed: 32270919 ( click the link to review the publication )

Lipids Health Dis, 2020, 19(1):207

PubMed: 32951592 ( click the link to review the publication )

DNA Cell Biol, 2020, 10.1089/dna.2019.5086

PubMed: 31999475 ( click the link to review the publication )

Biomed Res Int, 2020, 2020:2194090

PubMed: 32964021 ( click the link to review the publication )

Mol Cell Biochem, 2020, 10.1007/s11010-020-03985-3

PubMed: 33247805 ( click the link to review the publication )

Oral Dis, 2020, 10.1111/odi.13638

PubMed: 32890424 ( click the link to review the publication )

Mol Med Rep, 2020, 18

PubMed: 32468000 ( click the link to review the publication )

Mol Med Rep, 2020, 22(5):3904-3910

PubMed: 32901870 ( click the link to review the publication )

Braz Oral Res, 2020, 31;34:e006

PubMed: 32022225 ( click the link to review the publication )

Microbiol Immunol, 2020, 10.1111/1348-0421.12854

PubMed: 33026667 ( click the link to review the publication )

Int J Ophthalmol, 2020, 13(12):1887-1894

PubMed: 33344186 ( click the link to review the publication )

Int J Ophthalmol, 2020, 18;13(4):545-551

PubMed: 32399403 ( click the link to review the publication )

Theranostics, 2020, 10(26):12223-12240

PubMed: 33204339 ( click the link to review the publication )

Clin Transl Med, 2020, 10.1002/ctm2.41

PubMed: 32508052 ( click the link to review the publication )

Cell Death Dis, 2020, 11(8):626

PubMed: 32796811 ( click the link to review the publication )

Mol Neurobiol, 2020, 57(9):3891-3901

PubMed: 32613467 ( click the link to review the publication )
Metallomics, 2020, 10.1039/d0mt00209g

PubMed: 33313624 ( click the link to review the publication )

Artif Cells Nanomed Biotechnol, 2020, 48(1):377-383

PubMed: 31903787 ( click the link to review the publication )

Biomed Pharmacother, 2020, 121:109669

PubMed: 31766100 ( click the link to review the publication )

J Neuroinflammation, 2020, 17(1):75

PubMed: 32113469 ( click the link to review the publication )

bioRxiv, 2020, 2020/9/20.4.7.30734

PubMed: 32511305 ( click the link to review the publication )

Pflugers Arch, 2020, 472(5):583-596

PubMed: 32358780 ( click the link to review the publication )

iScience, 2020, 23(8):101428

PubMed: 32805647 ( click the link to review the publication )

Biochem Biophys Res Commun, 2020, S0006-291X(20)32148-3

PubMed: 33272569 ( click the link to review the publication )

Biomed Pharmacother, 2020, 130:110495

PubMed: 32688140 ( click the link to review the publication )

Biochem Biophys Res Commun, 2020, 524(4):1064-1071

PubMed: 32070494 ( click the link to review the publication )

Mol Cell Biochem, 2020, 10.1007/s11010-020-03985-3

PubMed: 33247805 ( click the link to review the publication )

Virol Sin, 2020, 10.1007/s12250-020-00320-4

PubMed: 33237393 ( click the link to review the publication )

Cancer Biomark, 2020, 27(1):75-84

PubMed: 31683461 ( click the link to review the publication )

Transl Res, 2020, S1931-5244(20)30250-4

PubMed: 33129993 ( click the link to review the publication )

Epilepsy Behav, 2020, 103(Pt A):106670

PubMed: 31864943 ( click the link to review the publication )

Oxid Med Cell Longev, 2020, 2020:7028947

PubMed: 32724493 ( click the link to review the publication )

bioRxiv, 2020, 2020.11.10.376277

PubMed: 33200127 ( click the link to review the publication )

Bone, 2020, 141:115573

PubMed: 32768686 ( click the link to review the publication )

Metabolism, 2020, 103:154044

PubMed: 31812628 ( click the link to review the publication )

Oral Dis, 2020, 10.1111

PubMed: 32068933 ( click the link to review the publication )

Int J Mol Sci, 2020, 21(19)E7210

PubMed: 33003599 ( click the link to review the publication )

Oral Dis, 2020, 10.1111

PubMed: 32176411 ( click the link to review the publication )

Cell Mol Immunol, 2020, 10.1038/s41423-020-0499-3

PubMed: 32669666 ( click the link to review the publication )

bioRxiv, 2020, 2020.11.10.376277

PubMed: 33200127 ( click the link to review the publication )
Viruses, 2020, 12(10)E1128

PubMed: 33028008 ( click the link to review the publication )

Theranostics, 2020, 10(20):9332-9347

PubMed: 32802195 ( click the link to review the publication )

Inflammation, 2020, 10.1007/s10753-020-01253-6

PubMed: 32500306 ( click the link to review the publication )

JCI Insight, 2020, 137528

PubMed: 33119551 ( click the link to review the publication )

Nan Fang Yi Ke Da Xue Xue Bao, 2020, 40(10):1439-1447

PubMed: 33118518 ( click the link to review the publication )

PLoS Biol, 2020, 18(12):e3000941

PubMed: 33264286 ( click the link to review the publication )

Biomed Res Int, 2020, 2020:5036572

PubMed: 32685494 ( click the link to review the publication )

J Hepatol, 2019, 71(1):163-174

PubMed: 30914267 ( click the link to review the publication )

Mol Cell, 2019, 74(2):254-267

PubMed: 30824372 ( click the link to review the publication )

J Allergy Clin Immunol, 2019, 143(1):229-244.e9

PubMed: 29625134 ( click the link to review the publication )

Nat Commun, 2019, 10(1):3371

PubMed: 31358760 ( click the link to review the publication )

Nat Commun, 2019, 10(1-:1128

PubMed: 30850660 ( click the link to review the publication )

Nat Commun, 2019, 10(1):2924

PubMed: 31266950 ( click the link to review the publication )

Autophagy, 2019, 10.1080/15548627.2019.1628540

PubMed: 31177911 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2019, 116(33):16404-16409

PubMed: 31358627 ( click the link to review the publication )

Theranostics, 2019, 9(4):1181-1199

PubMed: 30867824 ( click the link to review the publication )

Cell Rep, 2019, 27(6):1886-1896

PubMed: 31067471 ( click the link to review the publication )

Cell Death Differ, 2019, 26(7):1332-1345

PubMed: 30770876 ( click the link to review the publication )

J Control Release, 2019, 313:14-23

PubMed: 31622693 ( click the link to review the publication )

Cell Mol Immunol, 2019, 16(1):75-86

PubMed: 30467418 ( click the link to review the publication )

Cell Mol Immunol, 2019, 10.1038/s41423-019-0281-6

PubMed: 31467416 ( click the link to review the publication )

Cell Mol Immunol, 2019, 10.1038/s41423-019-0200-x

PubMed: 30760919 ( click the link to review the publication )

Oncogene, 2019, 38(10):1639-1650

PubMed: 30337688 ( click the link to review the publication )

Cancer Lett, 2019, 442:320-332

PubMed: 30391782 ( click the link to review the publication )
Cancer Lett, 2019, 446:1-14

PubMed: 30639532 ( click the link to review the publication )

Sci Signal, 2019, 12(605)

PubMed: 31662487 ( click the link to review the publication )

J Exp Clin Cancer Res, 2019, 38(1):463

PubMed: 31718704 ( click the link to review the publication )

Emerg Microbes Infect, 2019, 8(1):934-945

PubMed: 31237474 ( click the link to review the publication )

Cancers (Basel), 2019, 11(1)E75

PubMed: 30641867 ( click the link to review the publication )

Cancers (Basel), 2019, 11(12)E1881

PubMed: 31783584 ( click the link to review the publication )

PLoS Pathog, 2019, 15(12):e1008156

PubMed: 31790497 ( click the link to review the publication )

Free Radic Biol Med, 2019, 10.1016/j.freeradbiomed.2019.11.020

PubMed: 31770582 ( click the link to review the publication )

Free Radic Biol Med, 2019, 141:21-33

PubMed: 31167117 ( click the link to review the publication )

Cell Death Dis, 2019, 10(6):399

PubMed: 31113939 ( click the link to review the publication )

Cell Death Dis, 2019, 10(12):891

PubMed: 31767828 ( click the link to review the publication )

Cell Death Dis, 2019, 10(10):699

PubMed: 31541077 ( click the link to review the publication )

Cell Death Dis, 2019, 10(4):319

PubMed: 30967527 ( click the link to review the publication )

J Mol Cell Biol, 2019, 19;11(8):688-702

PubMed: 31152587 ( click the link to review the publication )

FASEB J, 2019, 33(6):7213-7224

PubMed: 30865837 ( click the link to review the publication )

FASEB J, 2019, 33(5):6551-6563

PubMed: 30794428 ( click the link to review the publication )

J Dent Res, 2019, 98(10):1131-1139

PubMed: 31343932 ( click the link to review the publication )

Mol Cancer Ther, 2019, 18(1):51-61

PubMed: 30337351 ( click the link to review the publication )

Cell Commun Signal, 2019, 17(1):75

PubMed: 31307477 ( click the link to review the publication )

J Neuroinflammation, 2019, 16(1):84

PubMed: 30981281 ( click the link to review the publication )

J Infect Dis, 2019, 220(10):1645-1654

PubMed: 31300818 ( click the link to review the publication )

Aging (Albany NY), 2019, 11(24):12532-12545

PubMed: 31841119 ( click the link to review the publication )

Aging (Albany NY), 2019, 11(22):10610-10625

PubMed: 31785145 ( click the link to review the publication )

J Biomed Nanotechnol, 2019, 15(6):1325-1333

PubMed: 31072439 ( click the link to review the publication )
Cell Prolif, 2019, 52(6):e12680

PubMed: 31454111 ( click the link to review the publication )

Cell Prolif, 2019, 52(3):e12575

PubMed: 30838710 ( click the link to review the publication )

Cell Prolif, 2019, 52(5):e12664

PubMed: 31343104 ( click the link to review the publication )

J Cancer, 2019, 10(26):6557-6569

PubMed: 31777585 ( click the link to review the publication )

Stem Cell Rev, 2019, 15(1):139-154

PubMed: 30302660 ( click the link to review the publication )

J Immunol, 2019, 203(2):500-510

PubMed: 31167775 ( click the link to review the publication )

J Immunol, 2019, 10.4049/jimmunol.1900169

PubMed: 31235551 ( click the link to review the publication )

Ecotoxicol Environ Saf, 2019, 171:467-474

PubMed: 30639873 ( click the link to review the publication )

J Cell Physiol, 2019, 10.1002/jcp.28278

PubMed: 30786006 ( click the link to review the publication )

J Cell Physiol, 2019, 234(12):22378-22385

PubMed: 31073998 ( click the link to review the publication )

J Cell Physiol, 2019, 10.1002/jcp.28810

PubMed: 31093976 ( click the link to review the publication )

Chemosphere, 2019, 103-111

PubMed: 31078025 ( click the link to review the publication )

Chemosphere, 2019, 244:125495

PubMed: 31837563 ( click the link to review the publication )

J Nutr Biochem, 2019, 69:108-119

PubMed: 31078904 ( click the link to review the publication )

Int J Nanomedicine, 2019, 14:963-976

PubMed: 30787610 ( click the link to review the publication )

J Virol, 2019, 93(22)e01249-19

PubMed: 31484746 ( click the link to review the publication )

J Cell Mol Med, 2019, 23(4):2933-2942

PubMed: 30761743 ( click the link to review the publication )

J Cell Mol Med, 2019, 23(8):5380-5389

PubMed: 31199046 ( click the link to review the publication )

J Cell Mol Med, 2019, 23(2):920-933

PubMed: 30394679 ( click the link to review the publication )

J Cell Mol Med, 2019, 23(7):4666-4678

PubMed: 31033175 ( click the link to review the publication )

Biochem Pharmacol, 2019, 10.1016/j.bcp.2019.07.008

PubMed: 31301277 ( click the link to review the publication )

Biochem Pharmacol, 2019, 166:70-81

PubMed: 31075266 ( click the link to review the publication )

Int J Mol Sci, 2019, 20(3)

PubMed: 30717477 ( click the link to review the publication )

Sci Rep, 2019, 9(1):840

PubMed: 30696869 ( click the link to review the publication )
Sci Rep, 2019, 9(1):1144

PubMed: 30718780 ( click the link to review the publication )

Am J Physiol Lung Cell Mol Physiol, 2019, 316(1):L20-L34

PubMed: 30260287 ( click the link to review the publication )

Int J Biol Sci, 2019, 15(8):1685-1695

PubMed: 31360111 ( click the link to review the publication )

Front Microbiol, 2019,

PubMed: 32038504 ( click the link to review the publication )

J Biol Chem, 2019, 294(46):17487-17500

PubMed: 31586032 ( click the link to review the publication )

J Biol Chem, 2019, 294(21):8384-8394

PubMed: 30971430 ( click the link to review the publication )

J Biol Chem, 2019, 294(9):3137-3151

PubMed: 30610118 ( click the link to review the publication )

Acta Pharmacol Sin, 2019, 40(4):546-555

PubMed: 29930276 ( click the link to review the publication )

Stem Cells Int, 2019, 2019:4793518

PubMed: 31015840 ( click the link to review the publication )

Int J Biol Macromol, 2019, 130:79-87

PubMed: 30659877 ( click the link to review the publication )

Front Pharmacol, 2019, 0.86041666667

PubMed: 31231225 ( click the link to review the publication )

Inflammopharmacology, 2019, 27(3):561-571

PubMed: 30251233 ( click the link to review the publication )

Mar Drugs, 2019, 17(1)E36

PubMed: 30626153 ( click the link to review the publication )

Mar Drugs, 2019, 17(9)E526

PubMed: 31505769 ( click the link to review the publication )

Mar Drugs, 2019, 17(1)

PubMed: 30669360 ( click the link to review the publication )

Toxicol Appl Pharmacol, 2019, 370:24-35

PubMed: 30857947 ( click the link to review the publication )

Toxicol Appl Pharmacol, 2019, 362:59-66

PubMed: 30352208 ( click the link to review the publication )

Toxicol Appl Pharmacol, 2019, 378:114617

PubMed: 31176653 ( click the link to review the publication )

Toxicol Appl Pharmacol, 2019, 370:36-43

PubMed: 30880218 ( click the link to review the publication )

Mediators Inflamm, 2019, 2019:6085801

PubMed: 30918469 ( click the link to review the publication )

Cell Signal, 2019, 54:17-26

PubMed: 30471465 ( click the link to review the publication )

Biomed Pharmacother, 2019, 116:109032

PubMed: 31163381 ( click the link to review the publication )

Brain Res Bull, 2019, 144:28-38

PubMed: 30179678 ( click the link to review the publication )

Life Sci, 2019, 229:1-12

PubMed: 30910647 ( click the link to review the publication )
J Cell Biochem, 2019, 120(8):12989-13000

PubMed: 30873661 ( click the link to review the publication )

Front Physiol, 2019, 10:24

PubMed: 30745880 ( click the link to review the publication )

Front Physiol, 2019, 10:1030

PubMed: 31507429 ( click the link to review the publication )

Cell Signal, 2019, 53:151-161

PubMed: 30290210 ( click the link to review the publication )

Exp Cell Res, 2019, 376(2):210-220

PubMed: 30690028 ( click the link to review the publication )

Cell Cycle, 2019, 18(21):2928-2938

PubMed: 31496351 ( click the link to review the publication )

Chem Biol Interact, 2019, 310:108741

PubMed: 31299238 ( click the link to review the publication )

Int J Chron Obstruct Pulmon Dis, 2019, 14:1741-1752

PubMed: 31496673 ( click the link to review the publication )

Am J Transl Res, 2019, 11(9):5824-5835

PubMed: 31632551 ( click the link to review the publication )

Mol Immunol, 2019, 107:10-20

PubMed: 30639474 ( click the link to review the publication )

Molecules, 2019, 24(6)

PubMed: 30889805 ( click the link to review the publication )

Am J Transl Res, 2019, 11(8):5122-5133

PubMed: 31497228 ( click the link to review the publication )

Eur J Pharmacol, 2019, 856:172409

PubMed: 31132355 ( click the link to review the publication )

Oncol Rep, 2019, 41(6):3270-3280

PubMed: 31002347 ( click the link to review the publication )

Free Radic Res, 2019, 53(3):348-358

PubMed: 30773942 ( click the link to review the publication )

Free Radic Res, 2019, 53(6):655-668

PubMed: 31185752 ( click the link to review the publication )

Cell Transplant, 2019, 10.1177/0963689719834870

PubMed: 30832493 ( click the link to review the publication )

Inflammation, 2019, 42(2):413-425

PubMed: 30613914 ( click the link to review the publication )

Dig Dis Sci, 2019, 10.1007/s10620-019-05656-w

PubMed: 31102128 ( click the link to review the publication )

Immunobiology, 2019, 224(3):388-396

PubMed: 30846331 ( click the link to review the publication )

PLoS One, 2019, 14(9):e0222559

PubMed: 31518371 ( click the link to review the publication )

Am J Reprod Immunol, 2019, 81(1):e13073

PubMed: 30461130 ( click the link to review the publication )

Biochem Biophys Res Commun, 2019, 511(4):847-854

PubMed: 30850160 ( click the link to review the publication )

Biochem Biophys Res Commun, 2019, 508(3):894-901

PubMed: 30528734 ( click the link to review the publication )
Biochem Biophys Res Commun, 2019, 516(3):872-879

PubMed: 31270028 ( click the link to review the publication )

Peptides, 2019, 114:17-28

PubMed: 30965084 ( click the link to review the publication )

Onco Targets Ther, 2019, 12:4391-4402

PubMed: 31239708 ( click the link to review the publication )

Integr Cancer Ther, 2019, 18:1534735418822120

PubMed: 30614302 ( click the link to review the publication )

Mol Cell Biochem, 2019, 457(1-2):179-189

PubMed: 30911956 ( click the link to review the publication )

Mol Cell Biochem, 2019, 462(1-2):41-50

PubMed: 31432386 ( click the link to review the publication )

Biochem Biophys Res Commun, 2019, 509(3):784-789

PubMed: 30635119 ( click the link to review the publication )

Reprod Sci, 2019, 26(3):394-403

PubMed: 29783884 ( click the link to review the publication )

Metab Brain Dis, 2019, 34(5):1355-1363

PubMed: 31134481 ( click the link to review the publication )

Scand J Immunol, 2019, 89(6):e12761

PubMed: 30977163 ( click the link to review the publication )

Acta Biochim Biophys Sin (Shanghai), 2019, 51(10):1056-1063

PubMed: 31555794 ( click the link to review the publication )

Pathol Oncol Res, 2019, 10.1007/s12253-019-00746-6

PubMed: 31598896 ( click the link to review the publication )

Oncol Lett, 2019, 18(1):181-188

PubMed: 31289487 ( click the link to review the publication )

Cell Biochem Biophys, 2019, 77(4):367-377

PubMed: 31659617 ( click the link to review the publication )

Auris Nasus Larynx, 2019, 46(1):106-113

PubMed: 29843929 ( click the link to review the publication )

Int J Ophthalmol, 2019, 12(4):549-556

PubMed: 31024805 ( click the link to review the publication )

Iran J Immunol, 2019, 16(1):1-10

PubMed: 30864551 ( click the link to review the publication )

Front Pharmacol, 2019, 10:368

PubMed: 31040780 ( click the link to review the publication )

Mar Drugs, 2019, 17(12)E660

PubMed: 31771286 ( click the link to review the publication )

Elife, 2019, 8e45418

PubMed: 31241461 ( click the link to review the publication )

Methods Mol Biol, 2019, 2005:101-124

PubMed: 31175649 ( click the link to review the publication )

Carbohydr Polym, 2019, 206:706-715

PubMed: 30553376 ( click the link to review the publication )

Mol Immunol, 2019, 107:21-28

PubMed: 30639475 ( click the link to review the publication )

Carbohydr Polym, 2019, 214:34-43

PubMed: 30926005 ( click the link to review the publication )
Eur J Pharmacol, 2019, 862:172623

PubMed: 31445014 ( click the link to review the publication )

Biochem Biophys Res Commun, 2019, 516(1):28-36

PubMed: 31186138 ( click the link to review the publication )

Biochem Biophys Res Commun, 2019, 519(3):469-474

PubMed: 31526568 ( click the link to review the publication )

Mol Cell Biochem, 2019, 455(1-2):195-206

PubMed: 30564960 ( click the link to review the publication )

JCI Insight, 2019, 5

PubMed: 31120863 ( click the link to review the publication )

Mol Med Rep, 2019, 19(6):4645-4654

PubMed: 30957188 ( click the link to review the publication )

Am J Chin Med, 2019, 913-931

PubMed: 31096773 ( click the link to review the publication )

Appl Microbiol Biotechnol, 2019, 103(15):6231-6243

PubMed: 31147754 ( click the link to review the publication )

Front Oncol, 2019, 9:1294

PubMed: 31828036 ( click the link to review the publication )

Nutrients, 2019, 11(4)E782

PubMed: 30987344 ( click the link to review the publication )

Exp Ther Med, 2019, 18(5):3431-3438

PubMed: 31602218 ( click the link to review the publication )

Carbohydr Polym, 2019, 226:115295

PubMed: 31582086 ( click the link to review the publication )

Mol Cell, 2018, 70(5):949-960

PubMed: 29861159 ( click the link to review the publication )

J Allergy Clin Immunol, 2018, 141(6):2196-2207

PubMed: 28888781 ( click the link to review the publication )

Nat Commun, 2018, 9(1):1017

PubMed: 29523821 ( click the link to review the publication )

Nat Commun, 2018, 9(1):873

PubMed: 29491374 ( click the link to review the publication )

Nucleic Acids Res, 2018, 46(10):5029-5049

PubMed: 29596642 ( click the link to review the publication )

Cancer Immunol Res, 2018, 6(10):1220-1233

PubMed: 30131377 ( click the link to review the publication )

Theranostics, 2018, 8(10):2846-2861

PubMed: 29774079 ( click the link to review the publication )

Cell Death Differ, 2018,

PubMed: 29674627 ( click the link to review the publication )

Elife, 2018, 7

PubMed: 29595474 ( click the link to review the publication )

Br J Pharmacol, 2018, 175(8):1329-1343

PubMed: 28294304 ( click the link to review the publication )

EBioMedicine, 2018, 28:51-61

PubMed: 29398601 ( click the link to review the publication )

Sci Signal, 2018, 11(525)

PubMed: 29636389 ( click the link to review the publication )
J Pathol, 2018, 244(3):346-357

PubMed: 29243822 ( click the link to review the publication )

PLoS Pathog, 2018, 14(8):e1007223

PubMed: 30161232 ( click the link to review the publication )

Cell Death Dis, 2018, 9(12):1140

PubMed: 30442927 ( click the link to review the publication )

FASEB J, 2018, 32(9):4917-4929

PubMed: 29630408 ( click the link to review the publication )

FASEB J, 2018, 10.1096/fj.201800548

PubMed: 29912587 ( click the link to review the publication )

Front Immunol, 2018, 9:2610

PubMed: 30483268 ( click the link to review the publication )

Oncoimmunology, 2018, 7(6):e1431086

PubMed: 29872558 ( click the link to review the publication )

Cell Physiol Biochem, 2018, 47(5):1769-1784

PubMed: 29953988 ( click the link to review the publication )

Cell Physiol Biochem, 2018, 45(3):899-916

PubMed: 29421811 ( click the link to review the publication )

Food Chem, 2018, 240:534-543

PubMed: 28946308 ( click the link to review the publication )

Hum Reprod, 2018, 33(11):2096-2106

PubMed: 30272163 ( click the link to review the publication )

Biochim Biophys Acta Mol Cell Biol Lipids, 2018, 1863(2):177-190

PubMed: 29217477 ( click the link to review the publication )

Cancer Sci, 2018, 109(8):2446-2457

PubMed: 29856906 ( click the link to review the publication )

J Cell Physiol, 2018, 234(1):454-463

PubMed: 29932210 ( click the link to review the publication )

Exp Neurol, 2018, 308:26-34

PubMed: 29940159 ( click the link to review the publication )

J Virol, 2018, 92(8)

PubMed: 29386287 ( click the link to review the publication )

J Cell Mol Med, 2018, 22(2):1283-1291

PubMed: 29083089 ( click the link to review the publication )

J Cell Mol Med, 2018, 22(9):4221-4235

PubMed: 29993192 ( click the link to review the publication )

Front Cell Neurosci, 2018, 12:309

PubMed: 30254570 ( click the link to review the publication )

Lab Invest, 2018, 98(3):339-359

PubMed: 29200203 ( click the link to review the publication )

Eur J Immunol, 2018, 48(11):1838-1850

PubMed: 30184256 ( click the link to review the publication )

Sci Rep, 2018, 8(1):18043

PubMed: 30575780 ( click the link to review the publication )

Front Microbiol, 2018, 9:3174

PubMed: 30622526 ( click the link to review the publication )

Cancer Cell Int, 2018, 18:209

PubMed: 30574018 ( click the link to review the publication )
Front Pharmacol, 2018, 9:21

PubMed: 29472856 ( click the link to review the publication )

Biomed Pharmacother, 2018, 97:941-947

PubMed: 29136772 ( click the link to review the publication )

Biomed Pharmacother, 2018, 102:772-781

PubMed: 29604597 ( click the link to review the publication )

Biomed Pharmacother, 2018, 105:320-325

PubMed: 29864620 ( click the link to review the publication )

Biomed Pharmacother, 2018, 107:1426-1433

PubMed: 30257359 ( click the link to review the publication )

Cancer Manag Res, 2018, 11:95-105

PubMed: 30588113 ( click the link to review the publication )

Tissue Eng Part A, 2018, 24(5-6):502-515

PubMed: 28602124 ( click the link to review the publication )

Toxicol Appl Pharmacol, 2018, 338:43-53

PubMed: 29128402 ( click the link to review the publication )

Metallomics, 2018, 10(3):486-495

PubMed: 29528074 ( click the link to review the publication )

Mediators Inflamm, 2018, 2018:1625414

PubMed: 29805311 ( click the link to review the publication )

Mediators Inflamm, 2018, 2018:7304096

PubMed: 30158835 ( click the link to review the publication )

Cell Signal, 2018, 43:85-94

PubMed: 29288710 ( click the link to review the publication )

J Cell Biochem, 2018, 119(11):9462-9473

PubMed: 30010216 ( click the link to review the publication )

J Agric Food Chem, 2018, 66(41):10721-10728

PubMed: 30257559 ( click the link to review the publication )

Phytother Res, 2018, 32(8):1521-1529

PubMed: 29672953 ( click the link to review the publication )

Exp Cell Res, 2018, 363(2):291-298

PubMed: 29355493 ( click the link to review the publication )

Exp Cell Res, 2018, 364(2):208-216

PubMed: 29427623 ( click the link to review the publication )

Exp Cell Res, 2018, 370(1):58-67

PubMed: 29894706 ( click the link to review the publication )

World J Gastroenterol, 2018, 24(40):4565-4577

PubMed: 30386106 ( click the link to review the publication )

BMC Cancer, 2018, 18(1):746

PubMed: 30021550 ( click the link to review the publication )

Toxicology, 2018, 408:62-69

PubMed: 29981841 ( click the link to review the publication )

Biochimie, 2018, 152:43-52

PubMed: 29960031 ( click the link to review the publication )

Int Immunopharmacol, 2018, 64:308-318

PubMed: 30243066 ( click the link to review the publication )

Molecules, 2018,

PubMed: 30513793 ( click the link to review the publication )
Transl Oncol, 2018, 11(4):988-998

PubMed: 29940414 ( click the link to review the publication )

Eur J Pharmacol, 2018, 839:12-20

PubMed: 30240794 ( click the link to review the publication )

Int J Mol Med, 2018, 41(5):3051-3062

PubMed: 29436589 ( click the link to review the publication )

Int J Mol Med, 2018, 42(4):1945-1954

PubMed: 30085341 ( click the link to review the publication )

Int J Mol Med, 2018, 42(6):3437-3446

PubMed: 30320381 ( click the link to review the publication )

Thromb Res, 2018, 171:121-129

PubMed: 30292134 ( click the link to review the publication )

PLoS One, 2018, 13(7):e0200878

PubMed: 30048489 ( click the link to review the publication )

Biochem Biophys Res Commun, 2018, 505(1):261-266

PubMed: 30245130 ( click the link to review the publication )

J Neuroimmunol, 2018, 316:17-22

PubMed: 29249556 ( click the link to review the publication )

Biochem Biophys Res Commun, 2018, 496(1):70-75

PubMed: 29305864 ( click the link to review the publication )

J Mol Neurosci, 2018, 66(2):163-171

PubMed: 30242669 ( click the link to review the publication )

Mol Med Rep, 2018, 17(4):5344-5349

PubMed: 29363726 ( click the link to review the publication )

Mol Med Rep, 2018, 18(5):4399-4409

PubMed: 30152849 ( click the link to review the publication )

Med Sci Monit, 2018, 24:1097-1103

PubMed: 29467361 ( click the link to review the publication )

Exp Lung Res, 2018, 44(6):288-301

PubMed: 30428724 ( click the link to review the publication )

Urology, 2018, 112:225.e1-225.e7

PubMed: 29154981 ( click the link to review the publication )

FEBS Open Bio, 2018, 8(12):1992-2001

PubMed: 30524949 ( click the link to review the publication )

J Neurogenet, 2018, 32(2):106-117

PubMed: 29718742 ( click the link to review the publication )

J Biosci, 2018, 43(5):857-865

PubMed: 30541946 ( click the link to review the publication )

Exp Ther Med, 2018, 16(4):3211-3219

PubMed: 30214544 ( click the link to review the publication )

Pflugers Arch, 2018, 470(3):559-570

PubMed: 29297096 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2018, 115(42):E9869-E9878

PubMed: 30275324 ( click the link to review the publication )

J Agric Food Chem, 2018, 66(31):8307-8318

PubMed: 29961319 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2018, 115(33):E7776-E7785

PubMed: 30061420 ( click the link to review the publication )
Oncol Rep, 2018, 40(1):518-526

PubMed: 29767236 ( click the link to review the publication )

Nat Cell Biol, 2017, 19(8):996-1002

PubMed: 28752853 ( click the link to review the publication )

Mol Cell, 2017, 68(1):185-197

PubMed: 28943315 ( click the link to review the publication )

Nat Struct Mol Biol, 2017, 24(6):534-543

PubMed: 28436945 ( click the link to review the publication )

Nat Commun, 2017, 8(1):1580

PubMed: 29146937 ( click the link to review the publication )

Autophagy, 2017, 13(8):1364-1385

PubMed: 28598230 ( click the link to review the publication )

Genes Dev, 2017, 31(20):2099-2112

PubMed: 29118048 ( click the link to review the publication )

EBioMedicine, 2017, 25:165-174

PubMed: 29050947 ( click the link to review the publication )

Antioxid Redox Signal, 2017, 27(2):73-92

PubMed: 27650197 ( click the link to review the publication )

Brain Behav Immun, 2017, 62:64-77

PubMed: 28189715 ( click the link to review the publication )

J Med Chem, 2017, 60(12):5162-5192

PubMed: 28541685 ( click the link to review the publication )

J Exp Clin Cancer Res, 2017, 36(1):123

PubMed: 28886730 ( click the link to review the publication )

PLoS Pathog, 2017, 13(4):e1006321

PubMed: 28394926 ( click the link to review the publication )

J Neurosci, 2017, 37(48):11701-11714

PubMed: 29084866 ( click the link to review the publication )

Cell Death Dis, 2017, 8(5):e2823

PubMed: 28542131 ( click the link to review the publication )

Cell Death Dis, 2017, 8(10):e3140

PubMed: 29072705 ( click the link to review the publication )

J Clin Endocrinol Metab, 2017, 102(8):2789-2797

PubMed: 28609824 ( click the link to review the publication )

Cell Death Dis, 2017, 8(3):e2715

PubMed: 28358372 ( click the link to review the publication )

Cell Death Dis, 2017, 8(9):e3052

PubMed: 28906489 ( click the link to review the publication )

Front Immunol, 2017, 8:1559

PubMed: 29209316 ( click the link to review the publication )

Oncoimmunology, 2017,

PubMed: 29123964 ( click the link to review the publication )

Cell Physiol Biochem, 2017, 44(5):1842-1855

PubMed: 29224011 ( click the link to review the publication )

Cell Physiol Biochem, 2017, 41(5):1957-1969

PubMed: 28391263 ( click the link to review the publication )

J Neuroinflammation, 2017, 14(1):67

PubMed: 28356158 ( click the link to review the publication )
Rheumatology (Oxford), 2017, 56(8):1417-1427

PubMed: 28431044 ( click the link to review the publication )

J Thromb Haemost, 2017, 15(8):1679-1688

PubMed: 28603902 ( click the link to review the publication )

Oncogenesis, 2017, 6(12):401

PubMed: 29284798 ( click the link to review the publication )

J Neurochem, 2017, 142(2):231-245

PubMed: 28444734 ( click the link to review the publication )

Environ Pollut, 2017, 228:287-296

PubMed: 28551559 ( click the link to review the publication )

J Cell Mol Med, 2017, 10.1111/jcmm

PubMed: 28176455 ( click the link to review the publication )

J Cell Mol Med, 2017, 21(2):208-221

PubMed: 27624867 ( click the link to review the publication )

J Cell Mol Med, 2017, 21(9):2077-2091

PubMed: 28266177 ( click the link to review the publication )

J Cell Mol Med, 2017, 21(3):552-567

PubMed: 27704688 ( click the link to review the publication )

Front Cell Neurosci, 2017, 11:290

PubMed: 28966577 ( click the link to review the publication )

J Transl Med, 2017, 15(1):158

PubMed: 28724379 ( click the link to review the publication )

Sci Rep, 2017, 7(1):14811

PubMed: 29093498 ( click the link to review the publication )

Sci Rep, 2017, 7(1):5736

PubMed: 28720813 ( click the link to review the publication )

Acta Pharmacol Sin, 2017, 38(4):488-497

PubMed: 28216620 ( click the link to review the publication )

Mol Pharmacol, 2017, 91(5):451-463

PubMed: 28202578 ( click the link to review the publication )

Apoptosis, 2017, 22(10):1296-1309

PubMed: 28766061 ( click the link to review the publication )

Endocrinology, 2017, 158(10):3281-3291

PubMed: 28651331 ( click the link to review the publication )

Int J Biol Macromol, 2017, 105(Pt 2):1446-1454

PubMed: 28739412 ( click the link to review the publication )

Mol Carcinog, 2017, 56(12):2663-2668

PubMed: 28767177 ( click the link to review the publication )

Immunol Cell Biol, 2017, 95(10):943-952

PubMed: 28878297 ( click the link to review the publication )

Biomed Pharmacother, 2017, 85:313-322

PubMed: 27903425 ( click the link to review the publication )

Biomed Pharmacother, 2017, 89:1277-1285

PubMed: 28320095 ( click the link to review the publication )

J Pharmacol Exp Ther, 2017, 361(1):39-50

PubMed: 28154014 ( click the link to review the publication )

Int J Oncol, 2017, 10.3892/ijo.2017.3910

PubMed: 28350136 ( click the link to review the publication )
Mediators Inflamm, 2017, 2017:1567120

PubMed: 28659662 ( click the link to review the publication )

Cell Signal, 2017, 39:74-83

PubMed: 28780319 ( click the link to review the publication )

J Cell Biochem, 2017, 118(2):263-275

PubMed: 27305863 ( click the link to review the publication )

Int J Chron Obstruct Pulmon Dis, 2017, 12:3341-3351

PubMed: 29200841 ( click the link to review the publication )

Am J Transl Res, 2017, 9(6):2878-2890

PubMed: 28670376 ( click the link to review the publication )

Int Immunopharmacol, 2017, 47:190-198

PubMed: 28415024 ( click the link to review the publication )

Eur J Pharmacol, 2017, 815:391-398

PubMed: 28970011 ( click the link to review the publication )

Oncol Rep, 2017, 38(1):591-597

PubMed: 28560404 ( click the link to review the publication )

Eur J Pharmacol, 2017, 809:87-97

PubMed: 28506909 ( click the link to review the publication )

Oncol Rep, 2017, 37(5):2795-2802

PubMed: 28393256 ( click the link to review the publication )

Int J Mol Med, 2017, 40(4):987-998

PubMed: 28849117 ( click the link to review the publication )

PLoS One, 2017, 12(1):e0168945

PubMed: 28060845 ( click the link to review the publication )

Biochem Biophys Res Commun, 2017, 487(4):820-826

PubMed: 28455228 ( click the link to review the publication )

Mol Cell Biochem, 2017, 433(1-2):141-148

PubMed: 28405849 ( click the link to review the publication )

Food Nutr Res, 2017, 61(1):1368321

PubMed: 28970779 ( click the link to review the publication )

Epilepsy Res, 2017, 133:89-92

PubMed: 28472735 ( click the link to review the publication )

Cell Biol Int, 2017, 41(12):1307-1315

PubMed: 28816402 ( click the link to review the publication )

Arch Oral Biol, 2017, 76:55-60

PubMed: 28126687 ( click the link to review the publication )

J Thorac Dis, 2017, 9(11):4398-4412

PubMed: 29268509 ( click the link to review the publication )

Mol Med Rep, 2017,

PubMed: 28259936 ( click the link to review the publication )

Mol Med Rep, 2017, 16(6):9652-9658

PubMed: 29039541 ( click the link to review the publication )

Mol Med Rep, 2017, 15(3):1079-1086

PubMed: 28098903 ( click the link to review the publication )

Mol Med Rep, 2017, 16(2):1417-1424

PubMed: 28627644 ( click the link to review the publication )

Med Sci Monit, 2017, 23:5283-5293

PubMed: 29107939 ( click the link to review the publication )
Anticancer Drugs, 2017, 28(6):596-602

PubMed: 28430744 ( click the link to review the publication )

Exp Ther Med, 2017, 13(3):1143-1150

PubMed: 28450955 ( click the link to review the publication )

Exp Ther Med, 2017, 13(6):3089-3096

PubMed: 28587384 ( click the link to review the publication )

Int J Clin Exp Pathol, 2017, 10(9):9400-9408

PubMed: 31966812 ( click the link to review the publication )

Ann Vasc Surg, 2017, 40:262-273

PubMed: 28167124 ( click the link to review the publication )

Oncotarget, 2017, 8(35):58417-58429

PubMed: 28938567 ( click the link to review the publication )

Anesthesiology, 2017, 126(5):868-881

PubMed: 28121635 ( click the link to review the publication )

Oncotarget, 2017, 8(68):112959-112971

PubMed: 29348880 ( click the link to review the publication )

Oncoimmunology, 2017, 6(3):e1282589

PubMed: 28405506 ( click the link to review the publication )

Sci Rep, 2017, 7:45056

PubMed: 28327597 ( click the link to review the publication )

J Am Heart Assoc, 2017, 6(12)

PubMed: 29197828 ( click the link to review the publication )

Sci Rep, 2017, 7(1):6529

PubMed: 28747804 ( click the link to review the publication )

Cell, 2017, 168(3):473-486

PubMed: 28129541 ( click the link to review the publication )

Oncotarget, 2017, 8(67):111333-111345

PubMed: 29340057 ( click the link to review the publication )

Oncotarget, 2017, 8(30):49824-49838

PubMed: 28548942 ( click the link to review the publication )

Oncotarget, 2017, 8(19):31297-31304

PubMed: 28415750 ( click the link to review the publication )

Nat Commun, 2016, 7:13674

PubMed: 27929088 ( click the link to review the publication )

Cancer Res, 2016,

PubMed: 27216177 ( click the link to review the publication )

Cell Mol Immunol, 2016, 13(4):524-34

PubMed: 26166769 ( click the link to review the publication )

J Crohns Colitis, 2016, 10(6):713-25

PubMed: 26818663 ( click the link to review the publication )

J Exp Clin Cancer Res, 2016, 35(1):101

PubMed: 27342319 ( click the link to review the publication )

Free Radic Biol Med, 2016, 90:230-42

PubMed: 26593748 ( click the link to review the publication )

Cell Death Dis, 2016, 7(10):e2435

PubMed: 27787522 ( click the link to review the publication )

Cell Death Dis, 2016,

PubMed: 26890145 ( click the link to review the publication )
Stem Cells, 2016, 34(8):2130-44

PubMed: 27096933 ( click the link to review the publication )

Mol Cancer Ther, 2016, 15(7):1485-1494

PubMed: 27196775 ( click the link to review the publication )

J Mol Cell Cardiol, 2016, 101:1-10

PubMed: 27789289 ( click the link to review the publication )

Mol Oncol, 2016, 10(6):775-88

PubMed: 26842883 ( click the link to review the publication )

Oxid Med Cell Longev, 2016, 2016:2572175

PubMed: 26962394 ( click the link to review the publication )

J Cell Mol Med, 2016, 20(5):920-9

PubMed: 26968871 ( click the link to review the publication )

Neuropharmacology, 2016, 101:98-109

PubMed: 26363192 ( click the link to review the publication )

Biochem Pharmacol, 2016, 104:8-18

PubMed: 26774454 ( click the link to review the publication )

Nutrients, 2016, 10.3390/nu8050272

PubMed: 27157787 ( click the link to review the publication )

Glycobiology, 2016, 26(6):623-34

PubMed: 26791445 ( click the link to review the publication )

Sci Rep, 2016, 6:37751

PubMed: 27874084 ( click the link to review the publication )

Sci Rep, 2016, 6:19720

PubMed: 26818472 ( click the link to review the publication )

J Biol Chem, 2016, 291(10):4939-54

PubMed: 26733204 ( click the link to review the publication )

J Biol Chem, 2016, 291(1):402-12

PubMed: 26487724 ( click the link to review the publication )

Mol Carcinog, 2016, 55(12):2268-2277

PubMed: 26840621 ( click the link to review the publication )

Obesity (Silver Spring), 2016, 24(6):1244-56

PubMed: 27028368 ( click the link to review the publication )

Int J Oncol, 2016, 49(6):2387-2398

PubMed: 27748800 ( click the link to review the publication )

Cytokine, 2016,

PubMed: 27081759 ( click the link to review the publication )

Mol Biol Cell, 2016, 10.1091/mbc.E15-11-0773

PubMed: 27280388 ( click the link to review the publication )

J Biomed Sci, 2016, 23(1):81

PubMed: 27863490 ( click the link to review the publication )

J Ethnopharmacol, 2016, 193:293-302

PubMed: 27553977 ( click the link to review the publication )

Invest Ophthalmol Vis Sci, 2016, 57(14):6123-6133

PubMed: 27832278 ( click the link to review the publication )

J Mol Endocrinol, 2016, 56(3):189-99

PubMed: 26647389 ( click the link to review the publication )

Toxicol Lett, 2016, 259:28-34

PubMed: 27480278 ( click the link to review the publication )
Arch Biochem Biophys, 2016, 609:31-38

PubMed: 27619643 ( click the link to review the publication )

J Dairy Sci, 2016, 99(11):9184-9198

PubMed: 27756472 ( click the link to review the publication )

Cell Immunol, 2016, 310:63-70

PubMed: 27687530 ( click the link to review the publication )

Inflamm Res, 2016, 65(3):193-202

PubMed: 26621504 ( click the link to review the publication )

Oncol Rep, 2016, 35(6):3341-8

PubMed: 27108927 ( click the link to review the publication )

Oncol Rep, 2016, 35(5):2691-8

PubMed: 26986967 ( click the link to review the publication )

Oncol Rep, 2016, 35(2):939-47

PubMed: 26555012 ( click the link to review the publication )

Neurochem Res, 2016, 41(11):3052-3062

PubMed: 27528245 ( click the link to review the publication )

PLoS One, 2016, 11(1):e0147034

PubMed: 26799794 ( click the link to review the publication )

PLoS One, 2016, 11(5):e0155748

PubMed: 27187745 ( click the link to review the publication )

Biochem Biophys Res Commun, 2016, 470(1):41-47

PubMed: 26742425 ( click the link to review the publication )

J Interferon Cytokine Res, 2016, 36(9):552-62

PubMed: 27348082 ( click the link to review the publication )

Cell Struct Funct, 2016, 10.1247/csf.16007

PubMed: 27247077 ( click the link to review the publication )

Eur Rev Med Pharmacol Sci, 2016, 20(2):250-63

PubMed: 26875893 ( click the link to review the publication )

J Biomol Screen, 2016, 21(3):277-89

PubMed: 26538432 ( click the link to review the publication )

Arch Virol, 2016, 161(3):699-703

PubMed: 26660165 ( click the link to review the publication )

Mol Med Rep, 2016, 14(1):839-44

PubMed: 27220355 ( click the link to review the publication )

Mol Med Rep, 2016, 13(5):4001-6

PubMed: 27035219 ( click the link to review the publication )

Pharm Biol, 2016, 54(10):2220-35

PubMed: 27049854 ( click the link to review the publication )

In Vitro Cell Dev Biol Anim, 2016, 52(1):120-9

PubMed: 26427712 ( click the link to review the publication )

Oncotarget, 2016,

PubMed: 27248176 ( click the link to review the publication )

Oncotarget, 2016, 7(15):19948-59

PubMed: 26942566 ( click the link to review the publication )

Oncotarget, 2016, 7(20):29102-15

PubMed: 27074555 ( click the link to review the publication )

Tumour Biol, 2016, 37(3):3727-38

PubMed: 26468015 ( click the link to review the publication )
Tumour Biol, 2016, 37(1):1025-33

PubMed: 26269112 ( click the link to review the publication )

Nat Commun, 2015, 6:6047

PubMed: 25581158 ( click the link to review the publication )

J Exp Med, 2015, 212(4):525-38

PubMed: 25824820 ( click the link to review the publication )

Leukemia, 2015, 29(4):918-926

PubMed: 25283842 ( click the link to review the publication )

J Med Chem, 2015, 58(1):183-96

PubMed: 25075558 ( click the link to review the publication )

FASEB J, 2015, 29(1):227-38

PubMed: 25361735 ( click the link to review the publication )

Stem Cells, 2015, 10.1002/stem.1990

PubMed: 25788415 ( click the link to review the publication )

Am J Cancer Res, 2015, 5(9):2660-72

PubMed: 26609474 ( click the link to review the publication )

Can J Cardiol, 2015, 10.1016/j.cjca.2015.01.013

PubMed: ( click the link to review the publication )

Can J Cardiol, 2015, 31(10):1272-81

PubMed: 26095939 ( click the link to review the publication )

J Cell Mol Med, 2015, 19(2):408-17

PubMed: ( click the link to review the publication )

J Cell Mol Med, 2015, 19(2):408-17

PubMed: 25388762 ( click the link to review the publication )

Am J Physiol Lung Cell Mol Physiol, 2015, 309(4):L333-47

PubMed: 26024891 ( click the link to review the publication )

J Cell Physiol, 2015, 10.1002/jcp.24888

PubMed: 25600161 ( click the link to review the publication )

J Nat Prod, 2015, 78(7):1689-96

PubMed: 26171689 ( click the link to review the publication )

Cytokine, 2015, 17:139-144

PubMed: ( click the link to review the publication )

Cytokine, 2015, 71(2):139-44

PubMed: 25461391 ( click the link to review the publication )

World J Gastroenterol, 2015, 21(15): 4547-4554

PubMed: ( click the link to review the publication )

World J Gastroenterol, 2015, 21(15):4547-54

PubMed: 25914463 ( click the link to review the publication )

Int Immunopharmacol, 2015, 26(1):229-236

PubMed: 25841318 ( click the link to review the publication )

Arch Biochem Biophys, 2015, 585:10-16

PubMed: 26363213 ( click the link to review the publication )

Toxicol In Vitro, 2015, 30(1 Pt B):521-8

PubMed: 26363202 ( click the link to review the publication )

J Cell Biochem, 2015, 10.1002/jcb.25219

PubMed: 25959126 ( click the link to review the publication )

PLoS One, 2015, 10(11):e0143685

PubMed: 26606677 ( click the link to review the publication )
PLoS One, 2015, 10(6):e0131141

PubMed: 26121660 ( click the link to review the publication )

PLoS One, 2015, 10(11):e0143777

PubMed: 26599016 ( click the link to review the publication )

J Neurol Sci, 2015, 357(1-2):270-5

PubMed: 26282496 ( click the link to review the publication )

Ultrasound Med Biol, 2015, 10.1016/j.ultrasmedbio.2015.01.014

PubMed: 25736607 ( click the link to review the publication )

Exp Biol Med, 2015, 10.1177/1535370215576312

PubMed: 25767191 ( click the link to review the publication )

Acta Biochim Biophys Sin, 2015, 47(7), 1–9

PubMed: 26071572 ( click the link to review the publication )

Evid Based Complement Alternat Med, 2015, 2015:307594

PubMed: 25802536 ( click the link to review the publication )

Tissue Cell, 2015, 47(3):301-10

PubMed: 25958163 ( click the link to review the publication )

Oncotarget, 2015, 6(17):14953-69

PubMed: 25879451 ( click the link to review the publication )

Cell Death Differ, 2015, 22(9):1463-76

PubMed: 25613375 ( click the link to review the publication )

Mol Cancer, 2015, 14:56

PubMed: 25890196 ( click the link to review the publication )

Tumour Biol, 2015, 36(2):973-81

PubMed: ( click the link to review the publication )

Oncotarget, 2015, 6(10):8244-54

PubMed: 25749519 ( click the link to review the publication )

Tumour Biol, 2015, 36(2):973-81

PubMed: 25318604 ( click the link to review the publication )

J Hepatol, 2015, 63(6):1378-89

PubMed: 26282231 ( click the link to review the publication )

Blood, 2014, 124(25):3791-8

PubMed: 25270909 ( click the link to review the publication )

Hepatology, 2014, 59(4):1262-72

PubMed: 23929627 ( click the link to review the publication )

Leukemia, 2014, 28(10):2109-12

PubMed: 24919804 ( click the link to review the publication )

Stem Cell Reports, 2014, 3(1):34-43

PubMed: 25068120 ( click the link to review the publication )

Mol Nutr Food Res, 2014, 58(3):528-36

PubMed: 24039193 ( click the link to review the publication )

Thromb Haemost, 2014, 112(5):992-1001

PubMed: 25057055 ( click the link to review the publication )

Antiviral Res, 2014, 110C:151-157

PubMed: 25131378 ( click the link to review the publication )

Biochem Pharmacol, 2014, 89(2):185-96

PubMed: 24607276 ( click the link to review the publication )

Helicobacter, 2014, 19(6):476-83

PubMed: 25231285 ( click the link to review the publication )
Apoptosis, 2014, 19(6):984-97

PubMed: 24699798 ( click the link to review the publication )

J Proteomics, 2014, 108:188-97

PubMed: 24882106 ( click the link to review the publication )

Int J Mol Sci, 2014, 15(2):2916-28

PubMed: 24566135 ( click the link to review the publication )

Oncol Rep, 2014, 32(6):2380-6

PubMed: 25231055 ( click the link to review the publication )

J Periodontal Res, 2014, 10.1111/jre.12193

PubMed: 24854880 ( click the link to review the publication )

J Periodontol, 2014, 85(12):1806-13

PubMed: 25186781 ( click the link to review the publication )

PLoS One, 2014, 9(1):e87311

PubMed: 24489893 ( click the link to review the publication )

PLoS One, 2014, 9(3):e91331

PubMed: 24618684 ( click the link to review the publication )

Virus Res, 2014, 192C:6-15

PubMed: 25150189 ( click the link to review the publication )

Evid Based Complement Alternat Med, 2014, Zhang JL

PubMed: ( click the link to review the publication )

Exp Hematol Oncol, 2014, 3:31

PubMed: 25937997 ( click the link to review the publication )

Oncotarget, 2014, 5(3):693-703

PubMed: 24525337 ( click the link to review the publication )

Eur Rev Med Pharmco, 2014, 18 (3): 338-343

PubMed: ( click the link to review the publication )

Experimental Hematology & Oncology, 2014, 小冶 03:31:00

PubMed: ( click the link to review the publication )

Mol Cancer, 2013, 12(1):133

PubMed: 24192080 ( click the link to review the publication )

Oncogene, 2013, 32(38):4529-38

PubMed: 23108402 ( click the link to review the publication )

Cancer Lett, 2013, 332(1):35-45

PubMed: 23340170 ( click the link to review the publication )

Cell Signal, 2013, 26(3):512-20

PubMed: 24308969 ( click the link to review the publication )

Biomed Pharmacother, 2013, 68(3):267-75

PubMed: 24406296 ( click the link to review the publication )

Am J Physiol Renal Physiol, 2013, 304(7):F938-47

PubMed: 23364805 ( click the link to review the publication )

PLoS One, 2013, 8(12):e83049

PubMed: 24376630 ( click the link to review the publication )

PLoS One, 2013, 8(12):e85032

PubMed: 24376862 ( click the link to review the publication )

Scand J Immunol, 2013, 78(5):401-7

PubMed: 23952047 ( click the link to review the publication )

Biochim Biophys Acta, 2012, 1823(5):987-96

PubMed: 22426621 ( click the link to review the publication )
Cytokine, 2012, 61(2):608-13

PubMed: 23178148 ( click the link to review the publication )

Connect Tissue Res, 2012, 53(3):207-19

PubMed: 22141456 ( click the link to review the publication )

Microbiol Immunol, 2012, 56(11):782-8

PubMed: 22938101 ( click the link to review the publication )

Mol Biochem Parasitol, 2011, 176(2):90-7

PubMed: 21185874 ( click the link to review the publication )

J Biol Chem, 2010, 285(43):32824-33

PubMed: 20729213 ( click the link to review the publication )

产品安全说明书

p38 MAPK抑制剂选择性比较

生物活性

产品描述

特性

SB203580是第一个被报道的p38抑制剂。

靶点

p38 MAPK ^[1] (THP-1 cells)	PKB ^[1] (THP-1 cells)
0.3 μM-0.5 μM	3 μM-5 μM

体外研究

SB203580作用于人类T细胞,鼠CT6 T细胞, 或BAF F7 B细胞，抑制IL-2诱导的增殖，IC50为3-5 μM。SB203580也抑制IL-2诱导的p70S6K激活, IC50 > 10 μM。SB203580也抑制PDK1活性，IC50为3-10 μM，这种抑制存在剂量依赖性。^[1]SB203580抑制MAPKAPK2中p38-MAPK的刺激，IC50 为0.07 μM, 然而抑制完整SAPK/JNK活性时，IC50为3-10 μM。SB203580 高浓度时激活ERK通路,随后增强NF-κB转录活性。^[2]SB203580作用于人类肝癌细胞(HCC)，诱导自体吞噬。^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
PC12	NH\SV\|BMcW6jc3WgRZN{[Xl?	M4S2flExKM7:TR?=	NWPrNYVkOTVibXnu		NEPyZ3pKdmirYnn0d{BxOzhiTVHQJItqdmG\|ZTD3bZRpKEmFNUCgc4YhOC54IN88US=>	M4SxRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd5NUC1O\|coRjd5NUC1O\|c9N2F-
THP-1	M3[xO2Z2dmO2aX;uJGF{e2G7				MU\Jcohq[mm2czDMVHMucW6mdXPl[EBVVk[jbIDoZUBxem:mdXP0bY9vKHerdHigTWM2OCCxZjCwMlE3KM7:TR?=	NX\ufGZwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNlU4PjhpPkG4N\|I2PzZ6PD;hQi=>
PBMC	Mke3SpVv[3Srb36gRZN{[Xl?		NF22e4syPSCvaX6=	NVLXOnlNTE2VTx?=	Mn3DTY5pcWKrdIOgeIhmKHKnbHXhd4Uhd2ZiaX70[ZJt\XWtaX6tNU1j\XSjIIfpeIghUUN3MDDv[kAxNjB\|NzFOwG0>	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjN4MUO5Okc,OTJ\|NkGzPVY9N2F-
SW1353	NETTTVlHfW6ldHnvckBCe3OjeR?=		Ml74NUBp	NHr2WG5FVVOR	MnjuTY5pcWKrdIOgTWwuPiCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjB3IN88US=>	NX7tZndyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGxOFA4PDFpPkGxNVQxPzRzPD;hQi=>
Hela	M3PYdWZ2dmO2aX;uJGF{e2G7			M2qzTGROW09?	Mo\iTY5pcWKrdIOgWIF1NWmwZIXj[YQhUEmYMTDMWHIhfHKjboPhZ5RqfmG2aX;uJIlvKGi3bXHuJGhmVGFiY3XscJMhf2m2aDDJR\|UxKG:oIECuNUDPxE1?	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDl{NkexNUc,OTh7Mk[3NVE9N2F-
PC12	NEjpeGVHfW6ldHnvckBCe3OjeR?=	M4K1T\|ExKM7:TR?=		MnHCSG1UVw>?	NH7vU45C[3SrdnH0[ZMhVnKoMj;BVmUhcW5icnH0JHBEOTJiY3XscJMh[XO\|ZYPz[YQh[XNiSF:tNUBxem:2ZXnuJIlv\HWldHnvci=>	NFLSRpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO0OVY5PSd-MkGzOFU3QDV:L3G+
RAW 264.7	NFOzc2ZEgXSxdH;4bYMhSXO\|YYm=	M13UelEzNjVizszN	MUmxNog>	MXLEUXNQ	NV\0cnhHSmyxY3vzJIxmfGijbDD0c5hqdi2vZXTpZZRm\CCleYTveI95cWOrdIm=	MkD5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2OEW1NFQoRjF5NEi1OVA1RC:jPh?=
HCA2	NEnzVmRHfW6ldHnvckBCe3OjeR?=	NWXuXWFXOi53IN88US=>			NVi4dmo6UW6qaXLpeJMheDN6IH3l[IlifGWmIF3LNkBi[3SrdnH0bY9v	MorlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7NkS3PFAoRjF5OU[0O\|gxRC:jPh?=
U937	M2PuWmZ2dmO2aX;uJGF{e2G7				MUjJcohq[mm2czDKRWsudWWmaXH0[YQhcW62ZYLm[ZJwdi2pYX3tZU9idmm\|b335Z4lvNWmwZIXj[YQhW3SjdEGgdIhwe3Cqb4L5cIF1cW:w	NYLO[3g2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUixOVcyOjJpPkG4NVU4OTJ{PD;hQi=>
U937	MUnGeY5kfGmxbjDBd5NigQ>?				NEHLdXdKdmirYnn0d{BLSUtvbXXkbYF1\WRiaX70[ZJn\XKxbj3nZY1u[S:jbnnzc416[2mwLXnu[JVk\WRicEO4JJBpd3OyaH;yfYxifGmxbh?=	NYW2cnBERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUixOVcyOjJpPkG4NVU4OTJ{PD;hQi=>
hESCs	M2\B[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWq1JO69VQ>?		M2XGfGROW09?	MlXkTY5lfWOnczDjZZJlcW:veX;n[Y5q[yCjY4Tpeol1gSCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bC=>	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZyMkO5PUc,OjN4MEKzPVk9N2F-
RAW264.7	NGO5WotHfW6ldHnvckBCe3OjeR?=	MnflNVAh\|ryP			MkDjTY5lfWOnczDhcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHL5JIlvcGmkaYTpcochUUxvMd8yJJJmdGWjc3W=	Ml3RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5OUGwO\|goRjJ\|N{mxNFc5RC:jPh?=
RAW264.7	NI\jT5FHfW6ldHnvckBCe3OjeR?=	MV[xNEDPxE1?			NV3kS3lsUW6mdXPld{BidnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIJ6KGmwaHnibZRqdmdiaV7PV{Bz\WynYYPl	MlTUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5OUGwO\|goRjJ\|N{mxNFc5RC:jPh?=
RAW264.7	NYjGeYdRTnWwY4Tpc44hSXO\|YYm=	NHXBVXcyOCEQvF2=			MVHJcoR2[2W\|IHHueIlqdm[uYX3tZZRwenliYXP0bZZqfHliYomgbY5pcWKrdHnu[{BPVyC{ZXzlZZNm	NYLSV45wRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3PVExPzhpPkKzO\|kyODd6PD;hQi=>
RAW264.7	NXzKUZI6TnWwY4Tpc44hSXO\|YYm=	M37NWVExKM7:TR?=			NFTOOm1KdmirYnn0d{BNWFNvaX7keYNm\CCyM{igUWFRUyCyaH;zdIhwenmuYYTpc44>	NIK3ZZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECxOlA2Pyd-MkSwNVYxPTd:L3G+
IEC-18	MUfGeY5kfGmxbjDBd5NigQ>?	M1;mcFExKM7:TR?=			MUTJcohq[mm2czDMVHMucW6mdXPl[EBxOzhiTVHQT{BxcG:\|cHjvdplt[XSrb36=	NFrITXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e1PFEyOCd-MkO3OVgyOTB:L3G+
Sf9	MWHGeY5kfGmxbjDhd5NigQ>?		NGr0c\|A{OCCvaX7z		M4nDN2lvcGmkaYTpc44hd2ZiZoXscE1t\W6pdHigSmxCTy14SHnzMXRGXiC2YXfn[YQhcHWvYX6gVmlROiCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDheZRweGixc4Doc5J6dGG2aX;uJJBz\S2rbnP1ZoF1\WRiZn;yJFMxKG2rboOg[o9tdG:5ZXSgZpkhcW6ldXLheIlwdiC5aYToJGFVWCCob4KgNkBpenNiYomgRWRRNUeubzDhd5NigSxiSVO1NEA:KDBwMEGg{txONg>?	NV64NGdxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OVU3PTRpPkK2OFU2PjV2PD;hQi=>
sf21	MV3GeY5kfGmxbjDhd5NigQ>?				NGO2OIdDcW6maX7nJIFn\mmwaYT5JJRwKHerbHSgeJlx\SCqdX3hckBjcW:2aX6gcIFj\WyuZXSgdFM5KGGucHjhJEg6KHSxIEO1NkBz\XOrZIXld{kh\XiycnXzd4VlKGmwIIPmNlEhcW6\|ZXP0JINmdGy\|IGPQVkBidmGueYPpd{whU2RiPTCwMlAzOTdizszNMi=>	MlizQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh6M{S0N\|EoRjJ6OEO0OFMyRC:jPh?=
PBMC	MYLGeY5kfGmxbjDhd5NigQ>?				MkXuTY5pcWKrdHnvckBw\iCWTl[tZYxxcGFicILv[JVkfGmxbjDifUBtcXCxcH;sfZNi[2OqYYLp[IUue3SrbYXsZZRm\CCqdX3hckBx\XKrcHjldoFtKGKub3;kJI1wdm:wdXPs[YFzKGOnbHzzMEBKSzVyIE2gNE4xOjVizszNMi=>	NWPFeZhKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUi3N\|c{OCd-OUi3N\|c{ODxxYU6=
PBMC	M4ftdWZ2dmO2aX;uJIF{e2G7				M320b2lvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhXEhtTl[tZYxxcHNicILv[JVkfGmxbjDifUBpfW2jbjDw[ZJqeGincnHsJIJtd2:mIH3vco9vfWOuZXHyJINmdGy\|IDjQRm1EeyluIFnDOVAhRSByLkCyOUDPxE1w	NIixVIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97N{i0NFk{Lz57N{i0NFk{RC:jPh?=
PBMC	M1n2NmZ2dmO2aX;uJIF{e2G7				NULFV5puUW6qaXLpeIlwdiCxZjDwN\|ghVUGSIHvpcoF{\SC{ZXzheIVlKFSQRj3hcJBp[SC{ZXzlZZNmKG[{b32gdIVzcXCqZYLhcEBjdG:xZDDtc45wdnWlbHXhdkBk\WyuczCoVGJOSyluIFnDOVAhRSByLkCzO{DPxE1w	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjB4MUi3Okc,OTJyNkG4O\|Y9N2F-
PBMC	MWLGeY5kfGmxbjDhd5NigQ>?				M33QW2lvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgTWwyNWKndHGgdJJw\HWldHnvckBqdiCqdX3hckBx\XKrcHjldoFtKGKub3;kJI1wdm:wdXPs[YFzKGOnbHzzLHBDVUO\|KTygTWM2OCB;IECuNFQ5KM7:TT6=	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86Pzh2MEmzK\|46Pzh2MEmzQE9iRg>?
SW1353	NWPHZXVuTnWwY4Tpc44h[XO\|YYm=				MWfDc41xd3WwZDD3ZZMh\X[jbIXheIVlKG[xcjDpeJMh[WKrbHn0fUB1dyCrbnjpZol1KEmOLU[gdJJw\HWldHnvckBqdiCVV{GzOVMh[2WubIOgeJJm[XSnZDD3bZRpKGO7dH;rbY5meyCLTD2xJIFv\CCWTl[sJGlEPTBiPTCwMlA2KM7:TT6=	NX7yW3VxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC5PVk1PjdpPkGwPVk6PDZ5PD;hQi=>
SW1353	MXPGeY5kfGmxbjDhd5NigQ>?				MnTITY5pcWKrdHnvckBw\iCWTl[gZY5lKEmOLUGgbY5lfWOnZDDJUE03KHC{b3T1Z5Rqd25iaX6gbJVu[W5iY3jvcoRzdy2\|YYLjc41iKFOZIEGzOVMh[2WubIOsJGlEPTBiPTCwMlA2KM7:TT6=	M4\BelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOUm5OFY5Lz5zMEm5PVQ3QDxxYU6=
THP1	NVrNNmx4TnWwY4Tpc44h[XO\|YYm=				MX3Jcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJGlNOSCycn;keYN1cW:wIHnuJIh2dWGwIGTIVFEh[2WubIOsJGlEPTBiPTCwMlA2KM7:TT6=	MnL5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyN{ezOlMoRjF6MEe3N\|Y{RC:jPh?=
THP1	MorlSpVv[3Srb36gZZN{[Xl?				MnXCTY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBVVk[jbIDoZUBxem:mdXP0bY9vKGmwIHj1cYFvKFSKUEGgZ4VtdHNuIFnDOVAhRSByLkC1JO69VS5?	Ml21QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyN{ezOlMoRjF6MEe3N\|Y{RC:jPh?=
THP1	NI\aTWJHfW6ldHnvckBie3OjeR?=				NGHXVGVKdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJJR2dW:{IH7lZ5Jwe2m\|IH\hZ5Rwei2jbIDoZUApXE6ILXHsdIhiMSCycn;keYN1cW:wIHnuJHRJWC1zIHPlcIx{NCCHQ{WwJF0hOC5yNjFOwG0v	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjB6NkS4OUc,OTJyOE[0PFU9N2F-
THP1	NEj6RpFHfW6ldHnvckBie3OjeR?=				NXi4fFM3UW6qaXLpeIlwdiCxZjD0eY1weiCwZXPyc5NqeyCoYXP0c5Ih[WyyaHGgdoVt\WG\|ZTDifUBVUFBvMTDj[YxteyxiSVO1NEA:KDBwMEeg{txONg>?	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTZ3OEi1OUc,OTV4NUi4OVU9N2F-
monocytic cell	M3PRWmZ2dmO2aX;uJIF{e2G7				Mn7OTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JHRPTi2jbIDoZUBxem:mdXP0bY9vKHW\|aX7nJIxqeG:yb3z5d4Fk[2ijcnnk[UB{fGmvdXzheIVlKGi3bXHuJI1wdm:leYTpZ{Bk\WyuczygTWM2OCB;IECuNFczKM7:TT6=	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjd{OU[zO{c,OTJ5Mkm2N\|c9N2F-
THP1	MV;GeY5kfGmxbjDhd5NigQ>?				MmLQTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGxRWy2\|dHnteYxifGWmIGTOSk1idHCqYTDwdo9lfWO2aX;uJIlvKGi3bXHuJI1wdm:leYTpZ{Bk\WyuczCoWGhRNTFrLDDJR\|UxKD1iMD6wO\|Ih\|ryPLh?=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTF\|OUe0PUc,OTVzM{m3OFk9N2F-
THP-1	NFTYeYlHfW6ldHnvckBie3OjeR?=				MXPJcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgcIlxd3CxbInzZYNkcGG{aXTlJJN1cW23bHH0[YQhXE6ILXHsdIhiKHC{b3T1Z5Rqd25iaX6gWGhRNTFiY3XscJMhMGi3bXHuJI1wdm:leYTpZ{Bk\WyuczmsJGlEPTBiPTCwMlA4OiEQvF2u	M37MV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3OEO3N\|ExLz5zNUizO\|MyODxxYU6=
THP1	MYrGeY5kfGmxbjDhd5NigQ>?				M4nlbGlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhXE6IYXzwbIEheHKxZIXjeIlwdiCrbjDUTHAyKGOnbHzzMEBKSzVyIE2gNE4xPzJizszNMi=>	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd3MEO2O{c,OTZ5NUCzOlc9N2F-
PBMC	MVrGeY5kfGmxbjDhd5NigQ>?				NXr0fpVzUW6qaXLpeIlwdiCxZjDzeIFxcHmub3PvZ4NidCCnboTldo91d3irbjDCLHNGSilic4TpcZVt[XSnZDD0eY1weiCwZXPyc5NqeyCoYXP0c5Ih[WyyaHGgLHRPTi2jbIDoZUkheHKxZIXjeIlwdiCkeTDoeY1idiCyZYLpdIhmemGuIHLsc49lKG2xbn;ueYNt\WG{IHPlcIx{MFCETVPzLUwhUUN3MDC9JFAvOTZizszNMi=>	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86Pzh2MEmzK\|46Pzh2MEmzQE9iRg>?
PBMC	M3XiSmZ2dmO2aX;uJIF{e2G7				M4P6UGNwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5pcWKrdDDsbZBweG:ueYPhZ4Np[XKrZHWgbY5lfWOnZDDUUmYu[WyyaHGgdoVt\WG\|ZTD3ZZMh\GW2ZYLtbY5m\CCrbjDoeY1idiCyZYLpdIhmemGuIHLsc49lKG2xbn;ueYNt\WG{IHPlcIx{NCCLQ{WwJF0hOC5zOTFOwG0v	M1yydVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NEW0NlMyLz5zNUS1OFI{OTxxYU6=
Sf9	M17FWmZ2dmO2aX;uJIF{e2G7				MX;Jcohq[mm2aX;uJI9nKG[3bHytcIVv\3SqIF\MRWcuPkircz3USXYhfGGpZ3XkJIh2dWGwIGLJVFIh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDifUBndHWxcnXzZ4VvfCCyb3zhdol7[XSrb36gZZN{[XluIFnDOVAhRSByLkKg{txONg>?	M3:zWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NEW1OlU1Lz5{NkS1OVY2PDxxYU6=
HEK293F	MU\GeY5kfGmxbjDhd5NigQ>?				NFTlfYRKdmirYnn0bY9vKG:oIIPv[Il2dSCjcoPlcoF1\SCjY4TpeoF1\WRiTj30[ZJucW6jbDDHV3QufGGpZ3XkJGJzfWerYTDtZYxigWliTWDLNUBmgHC{ZYPz[YQhcW5iSFXLNlk{TiClZXzsd{B2e2mwZzDGRW0ueDN6dHnk[UBieyC\|dXLzeJJifGViYomgTW1CWCCjc4PhfUwhUUN3MDC9JFAvOjJizszNMi=>	M3;POVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUSxN\|YzLz5{OUW0NVM3OjxxYU6=
HEK-293	Mni0SpVv[3Srb36gZZN{[Xl?				NVTQe3ZvUW6qaXLpeIlwdiCxZjDSTXAzUyCrbjDNSHAue3SrbYXsZZRm\CCKRVutNlk{KGOnbHzzJI93\XJvZYjwdoV{e2mwZzDOU2QzKGG\|c3Xzd4VlKGG\|IFnMPEB{\WO{ZYTpc44tKEmFNUCgQUAxNjJ3IN88UU4>	Mn\UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMEm4OlcoRjJ5MUC5PFY4RC:jPh?=
whole blood cell	NX\mUo5kTnWwY4Tpc44h[XO\|YYm=	MUWwMlAyKHSxIEGwNEB2VQ>?			NFztd4RKdmirYnn0bY9vKG:oIICzPE1z\WyjdHXkJGlNOS2kZYThJJJmdGWjc3WgZpkhf2ixbHWgZoxwd2RiY3XscJMh[XRiMUCg[U01KHSxIEGwJIUuQCCPLDDJR\|UxKD1iMD6zOUDPxE1w	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjh3Mke1OEc,OTJ6NUK3OVQ9N2F-
PBMC	M2\EfGZ2dmO2aX;uJIF{e2G7				MmfWTY5pcWKrdHnvckBw\iCyM{igUWFRKGurbnHz[UBz\WyjdHXkJHRPTi2jbIDoZUBz\WynYYPlJIZzd21icHXybZBp\XKjbDDicI9w\CCvb37vcpVkdGWjcjDj[YxteyBqUFLNR{ktKEmFNUCgQUAxNjV7IN88UU4>	MnHxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJyNkG4O\|YoRjF{ME[xPFc3RC:jPh?=
PBMC	NF3CelhHfW6ldHnvckBie3OjeR?=				MlTITY5pcWKrdHnvckBw\iC2aHWgdoVt\WG\|ZTDv[kB1fW2xcjDu[YNzd3OrczDmZYN1d3JiYXzwbIEh\nKxbTDw[ZJqeGincnHsJIJtd2:mIH3vco9vfWOuZXHyJINmdGy\|LDDJR\|UxKD1iMD61PUDPxE1w	NFTpXG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkO2NVM6Pid-MUKzOlE{QTZ:L3G+
PBMC	NF30RlVHfW6ldHnvckBie3OjeR?=				MoDCTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JHRPTi2jbIDoZUBz\WynYYPlJIlvKFCETTDj[YxteyxiSVO1NEA:KDBwNUmg{txONg>?	NWHxdWlERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK4OVI4PTRpPkGyPFUzPzV2PD;hQi=>
whole blood cell	NHTLeIFHfW6ldHnvckBie3OjeR?=	MUOwMlAyKHSxIEGwNEB2VQ>?			NE\XeXZKdmirYnn0bY9vKG:oIICzPE1z\WyjdHXkJHRPTi2jbIDoZUBz\WynYYPlJIJ6KHeqb3zlJIJtd2:mIHPlcIx{KGG2IEGwJIUuPCC2bzCxNEBmNThiTTygTWM2OCB;IECuPVQh\|ryPLh?=	NYTVVJJURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK4OVI4PTRpPkGyPFUzPzV2PD;hQi=>
BMDC	NWLEPHF6SW62aXnu[oxidW2jdH;yfUBie3OjeR?=		NFPLcFcyKGi{		NEHkeGFCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKEN3N1LMM\|YhdW:3c3WgRm1FSyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGxRWy2rbnT1Z4VlKEmOLU[gdJJw\HWldHnvckBxemWrbnP1ZoF1\WRiZn;yJFEhcHJicILpc5IhfG9iTGDTMZN1cW23bHH0bY9vKG2nYYP1doVlKGGodHXyJFE5KGi{czDifUBGVEmVQTygTWM2OCB;IEOuOUDPxE1w	M4fSb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MES3NlU6Lz5{NEC0O\|I2QTxxYU6=
BMDC	NGq4UIZCdnSraX7mcIFudWG2b4L5JIF{e2G7		NUDYPXBiOSCqch?=		MYXBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJGM2P0KOL{[gcY92e2ViQl3ER{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJGlNNTF{IIC0NEBxem:mdXP0bY9vKHC{ZXnuZ5Vj[XSnZDDmc5IhOSCqcjDwdolweiC2bzDMVHMue3SrbYXsZZRqd25ibXXhd5Vz\WRiYX\0[ZIhOThiaILzJIJ6KEWOSWPBMEBKSzVyIE2gOUDPxE1w	MnKxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyNEeyOVkoRjJ2MES3NlU6RC:jPh?=
HEK-293	MYjGeY5kfGmxbjDhd5NigQ>?				MVfJcohq[mm2aX;uJI9nKFKLUELLJIlvKFCjbULDV2s1NXO2aX31cIF1\WRiSFXLMVI6OyClZXzsd{BwfmW{LXX4dJJme3OrbnegWGxTOiCjc4Pld5Nm\CCjczDJUFghe2WlcnX0bY9vNCCLQ{WwJF0hPi5\|MTFOwG0v	M1jsc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUC5PFY4Lz5{N{GwPVg3PzxxYU6=
BMDC	NXLzbFB2SW62aXnu[oxidW2jdH;yfUBie3OjeR?=		NYDvNnNXOSCqch?=		MUXBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJGM2P0KOL{[gcY92e2ViQl3ER{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJHRPTmGucHjhJJBzd2S3Y4Tpc44heHKnaX7jeYJifGWmIH\vdkAyKGi{IIDybY9zKHSxIFzQV{1{fGmvdXzheIlwdiCvZXHzeZJm\CCjZoTldkAyQCCqcoOgZpkhTUyLU1GsJGlEPTBiPTC3MlUh\|ryPLh?=	NXHLOFBxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwOFczPTlpPkK0NFQ4OjV7PD;hQi=>
macrophage-like cell	NWLqe\|BHSW62aXnu[oxidW2jdH;yfUBie3OjeR?=		MnTKN\|AhdWmwcx?=		MX\BcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIFjMMVYxKGSncnn2[YQhdWGlcn;wbIFo\S2uaXvlJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgWG5H[WyyaHGgdJJw\HWldHnvckB1emWjdHXkJFMxKG2rboOgZoVnd3KnIFzQV{B{fGmvdXzheIlwdiCvZXHzeZJm\CCjZoTldkAzPCCqcoOgZpkhTUyLU1GsJGlEPTBiPTC4MlYh\|ryPLh?=	NYfDblJwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NVExQDlpPkKzPFEyODh7PD;hQi=>
WS	NE[1RpNHfW6ldHnvckBie3OjeR?=	NGjrfIgzNjVidV2=			M{fTRWlvcGmkaYTpc44hd2ZiYX7pd49ugWOrbj3pcoR2[2WmIGCzPE1idHCqYTDhZ5RqfmG2aX;uJIlvKGi3bXHuJIh2dWGwIGTFVnQucW2vb4L0ZYxqe2WmIGfTJINmdGy\|IHHzd4V{e2WmIHHzJGhUWDJ5IIDoc5NxcG:{eXzheIlwdiCjdDCyMlUhfU1?	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ3OUi3NUc,OTd4NUm4O\|E9N2F-
WS	M{\1[2Z2dmO2aX;uJIF{e2G7				MXzJcohq[mm2aX;uJI9nKE2NMjDt[YRq[XSnZDDIV3AzPyCyaH;zdIhwenmuYYTpc44hcW5iaX3tc5J1[Wyrc3XkJHdUKGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDGMYFkfGmwIIP0doV{eyCoaXLy[ZM>	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl4NEe4NEc,OTd7NkS3PFA9N2F-
WS	M1LEO2Z2dmO2aX;uJIF{e2G7				MnrTTY5pcWKrdHnvckBw\iCyM{igcYVlcWG2ZXSgUWszKGGldHn2ZZRqd25iaX6gW3Mh[2WubIO=	MlfoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7NkS3PFAoRjF5OU[0O\|gxRC:jPh?=
A673	MoH3dWhVWyCjc4PhfS=>				M3jkdJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCDNkezJINmdGy\|	NHv3TIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
Saos-2	MVnxTHRUKGG\|c3H5				NF3vO4NyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU3Hvd{0zKGOnbHzz	MoPtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
BT-37	NYPtWm9CeUiWUzDhd5NigQ>?				Mn7QdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKEKWLUO3JINmdGy\|	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
RD	MlfWdWhVWyCjc4PhfS=>				MnXqdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFKGIHPlcIx{	NXLFd2VFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
BT-12	NIC0RWdyUFSVIHHzd4F6				MmLzdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKEKWLUGyJINmdGy\|	NFP4[Iw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
OHS-50	NFvkcWlyUFSVIHHzd4F6				MWLxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhV0iVLUWwJINmdGy\|	Mmq4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
SJ-GBM2	NILsb3ByUFSVIHHzd4F6				MlTRdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFOMLVfCUVIh[2WubIO=	NXmwUY8zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
SK-N-MC	MW\xTHRUKGG\|c3H5				NH3yUm1yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1OSyClZXzsdy=>	M2m2TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	phospho-p38 / p38; PubMed: 25747578 PLoS Pathog Mock-infected RD cells were treated with SB203580 at different concentrations (10, 25, 50 and 100μM) or 1.0% DMSO (negative control) and cell lysates were harvested for Western blotting at 6h post-treatment. β-actin was included as a loading control. p-ASK1 / ASK1 / P-JNK / p-MKK4 / p-ERK; PubMed: 24082073 Infect Immun (B) AGS cells were infected with ASK1-HA-expressing adenoviruses for 24 h, pretreated with vehicle (DMSO) or 10 μM SB203580, and stimulated with or without H. pylori for 3 h. Immunoblots of the indicated proteins are shown. (C) AGS cells were transfected with NC or ASK1 siRNA for 48 h and treated with vehicle (DMSO) or 10 μM SB203580 for 4 h. Immunoblots of the indicated proteins are shown. phospho-MK2(T334) / phospho-HSP27(S82) / phospho-Akt(T308) / phospho-Akt(S473); PubMed: 21737674 Mol Biol Cell Lysates from wild-type MEFs pretreated with or without SB203580 (10 μM, 30 min) and exposed to H2O2 (100 μM) for the indicated duration were analyzed by immunoblotting with the indicated antibodies.	25747578 24082073 21737674
Immunofluorescence	dsRNA / hnRNP A1; PubMed: 25747578 PLoS Pathog RD cells were subjected to infection with EV71 and post-treated with SB203580 (p38 MAPK inhibitor) for 8h. SB203580-treated cells were fixed and the subcellular localisation of hnRNP A1 (red) was investigated by indirect immunofluorescence assay. Mock-infected and DMSO-treated cells were included as infection and solvent control, respectively. The images were taken at 100X magnification. Colocalisation quantification was based on the MOC using WCIF ImageJ software and represented as percent colocalisation at the respective drug concentrations. Error bars represent the standard deviation of duplicate data.	25747578
Growth inhibition assay	Cell viability ; PubMed: 23001390 Cytotechnology B16F10 cells were treated with a concentrations of SB203580 as indicated in figure a.	23001390

体内研究

SB203580作用于缺血性损伤，保护猪的心肌层。^[4] SB203580有效保护携带系统性红斑狼疮的MRL/lpr鼠和治疗疾病。^[5]

激酶实验： ^[1]	- 合并细胞受体激酶磷酸化实验 : 4 μg羊PKBα抗体固定在25 μL蛋白G-亲和层析柱上过夜(或1.5 小时) ，用Buffer A (50 mM Tris, pH 为7.5, 1 mM EDTA, 1 mM EGTA, 0.5 mM Na₃VO₄, 0.1% β-巯基乙醇，1% Triton X-100, 50 mM NaF, 5 mM焦磷酸钠, 0.1 mM苯甲磺酰氟, 1 μg/mL抑蛋白酶肽, 抑肽素, 亮抑酶肽,及1 μM微囊藻素)冲洗。固定的PKB抗体和0.5 ml细胞溶解物温育1.5小时，用含0.5 M NaCl的0.5 mL Buffer A冲洗三次, 再用0.5 mL Buffer B (含50 mM Tris-HCl, pH为7.5, 0.03% (w/v) Brij-35, 0.1 mM EGTA, 及 0.1% β-巯基乙醇)冲洗二次,最后用100 μL实验稀释buffer冲洗二次; 5×实验稀释buffer包含100 mM MOPS, pH为7.2, 125 mM β-甘油磷酸, 25 mM EGTA, 5 mM原钒酸钠, 及5 mM DTT。10 μL实验稀释buffer，40 μM蛋白激酶A抑制肽, 100 μM PKB-特定底物肽,及10 μCi [γ-³²P]ATP，加到PKB酶免疫复合物中。反应在室温下震荡温育20分钟，40 μL反应物转移到其他试管中，加入20 μL 40%三氯乙酸，终止反应。在室温下混合，温育5分钟，40 μL转移到P81磷酸纤维素纸上，亲和处理30秒。P81纸在0.75%磷酸中洗三次，然后在室温下加到丙酮中。使用闪烁计数器测量γ-³²P 渗透率。
细胞实验： ^[1]	- 合并 Cell lines: CT6细胞, BA/F3 F7细胞 Concentrations: 0-30 μM Incubation Time: 1小时 Method: CT6细胞和BA/F3 F7细胞在RPMI培养基中冲洗三次，然后培养在含5%胎牛血清，生长因子，抗生素，β-巯基乙醇的RPMI培养基中。2-5×10⁶个CT6细胞悬浮在含5%胎牛血清的2 ml RPMI培养基上, 用SB203580预处理。然后加入20 ng/ml重组人类IL-2，在37 ^oC下刺激细胞5分钟，离心30秒，溶解于合适buffer中。稳定表达IL-2受体β链缺失突变的BA/F3细胞维持在含谷氨酸，5%胎牛血清和0.2 μg/mL G418的RPMI培养基中。大规模冲洗细胞，过夜处理，在用IL-2激活前再次冲洗。通过测定[³H]胸苷的渗透率，进行细胞增殖实验。 (Only for Reference)
动物实验： ^[5]	- 合并 Animal Models: 携带系统性红斑狼疮的雌性MRL/lpr鼠和雌性C57BL/6鼠 Dosages: 0.4mL/天 Administration: 口服处理 (Only for Reference)

参考文献

- 合并

溶解度 (25°C)

体外	DMSO	43 mg/mL (113.92 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 4% DMSO+30% PEG 300+5% Tween 80+ddH2O	5mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download SB203580 SDF

分子量	377.43
化学式	C₂₁H₁₆FN₃OS
CAS号	152121-47-6
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	RWJ 64809, PB 203580

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

p38 MAPK Signaling Pathway Map

p38 MAPK Inhibitors with Unique Features

泛p38 MAPK抑制剂

SB202190 (FHPI) : Pan-p38α/β inhibitor, IC50=50 nM/100 nM.
活性最高的p38 MAPK抑制剂

Skepinone-L ^New : p38α-MAPK, IC50=5 nM.
用于临床的p38 MAPK抑制剂

PH-797804 : Phase II for Chronic Obstructive Pulmonary Disease (COPD).
最新的p38 MAPK抑制剂

Skepinone-L ^New : Selective p38α-MAPK inhibitor with IC50 of 5 nM.

研究领域

产品类型

定制您的化合物库

SB203580

客户使用Selleck生产的SB203580发表文献581篇：

产品安全说明书

p38 MAPK抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download SB203580 SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

技术支持

p38 MAPK Signaling Pathway Map

p38 MAPK Inhibitors with Unique Features

相关p38 MAPK产品