Staurosporine (AM-2282)

目录号:S1421 别名: Antibiotic AM-2282, STS 中文名称:星形孢菌素

仅限科研使用

Staurosporine (AM-2282, Antibiotic AM-2282, STS)是一种有效的PKC抑制剂,在无细胞试验中作用于PKCα,PKCγ 和PKCη,IC50分别为2 nM,5 nM 和 4 nM,对PKCδ(20 nM)和PKCε(73 nM作用较弱,对PKCζ (1086 nM)的活性很低。同时 对其他的激酶PKA, PKG, S6K, CaMKII, 等也显示抑制活性。Phase 3。

Staurosporine (AM-2282) Chemical Structure

CAS: 62996-74-1

规格 价格 库存 购买数量
RMB 2186.89 现货
RMB 4095.0 现货
RMB 12203.1 现货
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客户使用Selleck生产的Staurosporine (AM-2282)发表文献114篇:

产品安全说明书

Antineoplastic and Immunosuppressive Antibiotics抑制剂选择性比较

生物活性

产品描述 Staurosporine (AM-2282, Antibiotic AM-2282, STS)是一种有效的PKC抑制剂,在无细胞试验中作用于PKCα,PKCγ 和PKCη,IC50分别为2 nM,5 nM 和 4 nM,对PKCδ(20 nM)和PKCε(73 nM作用较弱,对PKCζ (1086 nM)的活性很低。同时 对其他的激酶PKA, PKG, S6K, CaMKII, 等也显示抑制活性。Phase 3。
靶点
PKCα [1]
(Cell-free assay)
c-Fgr [2]
(Cell-free assay)
phosphorylase kinase [2]
(Cell-free assay)
PKCη [1]
(Cell-free assay)
PKCγ [1]
(Cell-free assay)
点击更多
2 nM 2 nM 3 nM 4 nM 5 nM
体外研究

Staurosporine 也强抑制HeLa S3细胞,IC50为4 nM。[1]Staurosporine 也抑制多种其他蛋白激酶,包括PKA, PKG, 磷酸激酶, S6 激酶, 肌球蛋白轻链激酶(MLCK), CAM PKII, cdc2, v-Src, Lyn, c-Fgr, 和Syk , IC50分别为 15 nM, 18 nM, 3 nM, 5 nM, 21 nM, 20 nM, 9 nM, 6 nM, 20 nM, 2 nM, 和 16 nM。[3] Staurosporine (1 μM) 诱导 PC12细胞90%以上凋亡,这种作用可被过量表达的Bcl-2抑制,或者zVAD-fmk, cycloheximide (10 μM) 及actinomycin D (5 μM)处理也可抑制。相应地, Staurosporine处理,诱导细胞内游离钙水平 [Ca2+]i快速且持久的提升,线粒体活性氧(ROS)的积累,及 随后的线粒体功能障碍。[4]通过caspase-8激活和Bid 分裂,功能性caspase-3的表达可增强Staurosporine诱导MCF7细胞死亡。[5] 1 μM Staurosporine处理,只部分抑制IL-3刺激的Bcl2 磷酸化,而完全阻断PKC调节的 Bcl2磷酸化。[6] Staurosporine 诱导人类包皮成纤维细胞AG-1518凋亡,根据溶酶体组织蛋白酶D调节的 细胞色素 c释放和 caspase 激活。[7] 除了激活传统线粒体凋亡通路, Staurosporine触发一种新型内在凋亡通路, 依赖Apaf-1存在时对caspase-9的激活。[8]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human colon carcinoma cell line HCT116 MkTySpVv[3Srb36gZZN{[Xl? NVvrPJh3S2:wY3XueJJifGmxbjDy[ZF2cXKnZDDmc5Ih\3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4h[2:ub36gZ4Fz[2mwb33hJINmdGxibHnu[UBJS1RzMU[sJGlEPTB;NjDuUU4> MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTV|N{O0OUc,OTV3M{ezOFU9N2F-
human PBMC NX7ucYJFTnWwY4Tpc44h[XO|YYm= MoezNlQhcA>? M4PhdnN2eHC{ZYPzbY9vKG:oIFnMNkBxem:mdXP0bY9vKGmwIHj1cYFvKFCETVOgZYZ1\XJiMkSgbJJ{KGK7IFXMTXNCNCCLQ{WwQVE3KG6PLh?= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV6NUC0Okc,OTh3OEWwOFY9N2F-
endothelial cells NVT2Z445TnWwY4Tpc44h[XO|YYm= MUHF[oZm[3SrdnWg[I9{\SCjZ3HpcpN1KHCuYYPtbY5w\2WwIHHjeIl3[XSxcjDhZ5Rqfmm2eTDzeIlufWyjdHXkJIJ6KHCqb4Lic4wh\XO2ZYKgbY4h\W6mb4To[Yxq[WxiY3XscJMtKEWGNUCgQUA4NjVizszNMi=> M{XqXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh5MEmwPVUoRjh5MEmwPVU9N2F-
Sf9 insect cells Mly3SpVv[3Srb36gZZN{[Xl? M2q4dmlvcGmkaYTpc44hd2ZicILveIVqdiCtaX7hd4UhSyhzOkHtbZh1fXKnIH;mJHBMSyCjbIDoZUAnKGKndHGpJIV5eHKnc4Pl[EBqdiCVZkmgbY5{\WO2IHPlcIx{NCCLQ{WwJF0hOC5yMjFOwG0v M1S4TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl6N{O2NFUoRjl6N{O2NFU9N2F-
LoVo cells NX3TbGo4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= Mm\IRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiClb3zvckBk[W6lZYKgZ4VtdCCuaX7lJEhNd1[xIHPlcIx{MSC3c3nu[{BOXFRiYYPzZZktKEmFNUCgQUAxNjByMTFOwG0v M3jHVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzNUmxOVA2Lz5zMUW5NVUxPTxxYU6=
umbilical vein endothelial cells NInTWWRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MVfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKHWvYnnsbYNidCC4ZXnuJIVv\G:2aHXsbYFtKGOnbHzzJEhJXV[HQ4OpJJV{cW6pIF3UWEBie3OjeTygTWM2OCB;IECuNFA1KM7:TT6= MmrjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF3OUG1NFUoRjFzNUmxOVA2RC:jPh?=
ST-486 cells NFv3eohCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M2P2U2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgZpVzc2m2IHz5cZBpd22jIHPlcIwhdGmwZTCoV3QuPDh4IHPlcIx{MSC3c3nu[{BOXFRiYYPzZZktKEmFNUCgQUAxNjByNzFOwG0v MmXVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF3OUG1NFUoRjFzNUmxOVA2RC:jPh?=
DLD-1 cells M136cGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MYHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKGOxbH;uJINidmOncjDj[YxtKGyrbnWgLGRNTC1zIHPlcIx{MSC3c3nu[{BOXFRiYYPzZZktKEmFNUCgQUAxNjByOTFOwG0v M4\wZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzNUmxOVA2Lz5zMUW5NVUxPTxxYU6=
HEK293 cells M4TzPWZ2dmO2aX;uJIF{e2G7 MY\Jcohq[mm2aX;uJI9nKFCNQz3i[ZRiKEmLIH3l[IlifGWmIFnMMVghemWuZXHz[UBnem:vIFjFT|I6OyClZXzsd{BjgSCHTFnTRUwhUUN3MDC9JFAvODd5IN88UU4> NYTvXXBTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK5OFE{OzFpPkGyPVQyOzNzPD;hQi=>
P19 cells MVfGeY5kfGmxbjDhd5NigQ>? NWLuOXBiUW6qaXLpeIlwdiCxZjDQcIF1\WyndD3k[ZJqfmWmIHfyc5d1cCCoYXP0c5IhemWlZYD0c5IhcW5iUEG5JINmdGy|LDDJR|UxKD1iMD6wNFIh|ryPLh?= NEHVUFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUe3NVQyQSd-MUW3O|E1OTl:L3G+
P19 cells NEjx[|BHfW6ldHnvckBie3OjeR?= NIS0PZVKdmirYnn0bY9vKG:oIGDsZZRmdGW2LXTldol3\WRiZ4Lve5RpKG[jY4TvdkBz\WOncITvdkBqdiCSMUmgZ4VtdHNuIFnDOVAhRSByLkCwNkDPxE1w NIrEc5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUe3NVQyQSd-MUW3O|E1OTl:L3G+
P19 cells NXrvPYhJTnWwY4Tpc44h[XO|YYm= MXjJcohq[mm2aX;uJI9nKFC{b4TlbY4hU2mwYYPlJGEhcW5iUEG5JINmdGy|LDDJR|UxKD1iMD6wNFQh|ryPLh?= NWnhfW9sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3O|E1OTlpPkG1O|cyPDF7PD;hQi=>
P19 cells M3y5OmZ2dmO2aX;uJIF{e2G7 MljaTY5pcWKrdHnvckBw\iCFYXzjbZVuN2OjbH3v[JVtcW5vZHXw[Y5l\W62IIDyc5RmcW5ia3nuZZNmKHS7cHWgTWkhcW5iUEG5JINmdGy|LDDJR|UxKD1iMD6wNFYh|ryPLh?= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTd5MUSxPUc,OTV5N{G0NVk9N2F-
P19 cells MUPGeY5kfGmxbjDhd5NigQ>? NXO3PWw2UW6qaXLpeIlwdiCxZjDDfYNtcW5vZHXw[Y5l\W62IHvpcoF{\SBzIHnuJHAyQSClZXzsd{whUUN3MDC9JFAvODB6IN88UU4> NIr4UY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUe3NVQyQSd-MUW3O|E1OTl:L3G+
P19 cells NELDeoxHfW6ldHnvckBie3OjeR?= MoPyTY5pcWKrdHnvckBw\iCYYYPjeYxieiCnbnTveIhmdGmjbDDndo94fGhiZnHjeI9zKHKnY3XweI9zKGmwIGCxPUBk\WyuczygTWM2OCB;IECuNFE1KM7:TT6= NHf0[Gg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUe3NVQyQSd-MUW3O|E1OTl:L3G+
HEK293 cells MnzTSpVv[3Srb36gZZN{[Xl? MmPjTY5pcWKrdHnvckBw\iCLTD24JJJmdGWjc3WgZpkhUEWNMkmzJINmdGy|IHX4dJJme3OrbnegVGtENWKndHGyMEBKSzVyIE2gNE4xPzdizszNMi=> MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTd5MUSxPUc,OTV5N{G0NVk9N2F-
P19 cells M{TlbmZ2dmO2aX;uJIF{e2G7 MYTJcohq[mm2aX;uJI9nKEmwc4XsbY4hemWlZYD0c5Ihc2mwYYPlJIlvKFBzOTDj[YxteyxiSVO1NEA:KDBwMjFOwG0v MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTd5MUSxPUc,OTV5N{G0NVk9N2F-
P19 cells MYXGeY5kfGmxbjDhd5NigQ>? MnvqTY5pcWKrdHnvckBw\iCFYYPlbY4hc2mwYYPlJFEhcW5iUEG5JINmdGy|LDDJR|UxKD1iMT60JO69VS5? MkmzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV5N{G0NVkoRjF3N{exOFE6RC:jPh?=
FL5.12-Akt1 cells MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M4nYcmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgSmw2NjF{LVHreFEh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5{OTFOwG0v M1LlVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NECzOlI3Lz5zNkSwN|YzPjxxYU6=
MiaPaCa-2 cells MXPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IF3pZXBiS2FvMjDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlM4KM7:TT6= M3OzclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NECzOlI3Lz5zNkSwN|YzPjxxYU6=
FL5.12-Akt1 cells MULGeY5kfGmxbjDhd5NigQ>? MYnBZ5Rqfmm2eTDh[4FqdnO2IFfTT|MhcW5iRly1MlEzNUGtdEGgZ4VtdHNuIFXDOVAhRSByLkS2JO69VS5? MlLTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2MEO2NlYoRjF4NECzOlI3RC:jPh?=
MiaPaCa-2 cells MnG4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MnrqRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPaXHQZWNiNTJiY3XscJMtKEmFNUCgQUAxNjN5IN88UU4> NHfYcY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkSxN|c5OCd-MU[0NVM4QDB:L3G+
FL5.12-Akt1 cells NUXWXpU1TnWwY4Tpc44h[XO|YYm= NEL2bIFC[3Srdnn0fUBi\2GrboP0JGdUUzNicHjvd5Bpd3K7bHH0bY9vKGmwIF\MOU4yOi2Da4SxJINmdGy|LDDFR|UxKD1iMD60OkDPxE1w NYnJRlNyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NVM4QDBpPkG2OFE{PzhyPD;hQi=>
Sf21 cells MXXGeY5kfGmxbjDhd5NigQ>? Ml\uTY5pcWKrdHnvckBw\iCMQVuzJIV5eHKnc4Pl[EBqdiCVZkKxJINmdGy|LDDJR|UxKD1iMD6wNFYh|ryPLh?= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB6OEC1PUc,OTdyOEiwOVk9N2F-
U937 cells M2fUTmN6fG:2b4jpZ4l1gSCjc4PhfS=> NVLvUVB6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTl|NzDj[YxteyxiSVO1NEA:KDJizszNMi=> MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB6OEC2O{c,OTdyOEiwOlc9N2F-
Sf9 cells MmjySpVv[3Srb36gZZN{[Xl? MYCxJI1qdg>? NGLXVppKdmirYnn0bY9vKG:oIHj1cYFvKE[7bjDlfJBz\XO|ZXSgbY4hW2Z7IHPlcIx{KGGodHXyJFEhdWmwIHL5JGVNUVODIHnuJJBz\XOnbnPlJI9nKDFidX3vcE9NKEGWUDygTWM2OCB;IECuNFA2KM7:TT6= MlrpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|MUW4OVMoRjF5M{G1PFU{RC:jPh?=
Sf9 cells MofJSpVv[3Srb36gZZN{[Xl? NWnuT4s2OjBibXnudy=> NHHUWY1KdmirYnn0bY9vKG:oIHj1cYFvKE[7bjDlfJBz\XO|ZXSgbY4hW2Z7IHPlcIx{KGGodHXyJFIxKG2rboOgZpkhTUyLU1GgbY4heHKnc3XuZ4Uhd2ZiMTD1cY9tN0xiQWTQMEBKSzVyIE2gNE4xOTVizszNMi=> MlrZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|MUW4OVMoRjF5M{G1PFU{RC:jPh?=
Sf9 cells MnnhSpVv[3Srb36gZZN{[Xl? MWmxJI1qdg>? MXLJcohq[mm2aX;uJI9nKGi3bXHuJGZ6diCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJIFnfGW{IEGgcYlvKGK7IFXMTXNCKGmwIIDy[ZNmdmOnIH;mJFExKHWvb3yvUEBCXFBuIFnDOVAhRSByLkCzOkDPxE1w NUG3TG9lRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezNVU5PTNpPkG3N|E2QDV|PD;hQi=>
Sf9 cells MljZSpVv[3Srb36gZZN{[Xl? M4[0WlIxKG2rboO= NXXXe2wzUW6qaXLpeIlwdiCxZjDoeY1idiCIeX6g[ZhxemW|c3XkJIlvKFOoOTDj[YxteyCjZoTldkAzOCCvaX7zJIJ6KEWOSWPBJIlvKHC{ZYPlcoNmKG:oIEGwJJVud2xxTDDBWHAtKEmFNUCgQUAxNjB6MzFOwG0v MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzNzNUi1N{c,OTd|MUW4OVM9N2F-
Sf9 cells MoTDSpVv[3Srb36gZZN{[Xl? MonSNUBucW5? MkjuTY5pcWKrdHnvckBw\iCqdX3hckBHgW5iZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bi\nSncjCxJI1qdiCkeTDFUGlUSSCrbjDwdoV{\W6lZTDv[kAyODBidX3vcE9NKEGWUDygTWM2OCB;IECuNlch|ryPLh?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzNzNUi1N{c,OTd|MUW4OVM9N2F-
Sf9 cells MWLGeY5kfGmxbjDhd5NigQ>? MYWyNEBucW6| MXvJcohq[mm2aX;uJI9nKGi3bXHuJGZ6diCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJIFnfGW{IEKwJI1qdnNiYomgSWxKW0FiaX6gdJJme2WwY3Wgc4YhOTByIIXtc4wwVCCDVGCsJGlEPTBiPTCwMlUyKM7:TT6= NEPqWXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{OxOVg2Oyd-MUezNVU5PTN:L3G+
A549 cells NWHTU3JUS3m2b4TvfIlkcXS7IHHzd4F6 NGLKe|A4OiCq NF\0OlBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFczKGi{czDifUB{fWyob4Loc4RidWmwZTDCJI1mfGixZDygS2k2OCB;IECuNFAzPCEQvF2u MlfqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2OES3O|UoRjF6NEi0O|c2RC:jPh?=
MDA-MB-231 cells NFTVUJlEgXSxdH;4bYNqfHliYYPzZZk> M1SxVVczKGh? M1vsSmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJibXX0bI9lNCCJSUWwJF0hOC5yMEexJO69VS5? M4m1RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NEi0O|c2Lz5zOES4OFc4PTxxYU6=
HT29 cells M16yfmN6fG:2b4jpZ4l1gSCjc4PhfS=> Mn3yO|IhcA>? NVzRTphLS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFR{OTDj[YxteyCjZoTldkA4OiCqcoOgZpkhe3WuZn;ybI9l[W2rbnWgRkBu\XSqb3SsJGdKPTBiPTCwMlAyODlizszNMi=> NXu1eFNiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0PFQ4PzVpPkG4OFg1Pzd3PD;hQi=>
MCF7 cells M4rvSmZ2dmO2aX;uJIF{e2G7 NYLS[IlwUW6qaXLpeIlwdiCxZjDQT2EhcW5iaIXtZY4hVUOINzDj[YxteyCkeTDhdpJigS2kYYPl[EBndHWxcnXzZ4Vv[2ViYYPzZZktKEurIE2gNE4xODVizszNMi=> M2D4[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NkW2N|Y6Lz5zOE[1OlM3QTxxYU6=
MCF7 cells MX7GeY5kfGmxbjDhd5NigQ>? Ml;OTY5pcWKrdHnvckBw\iCSS1GgbY4hcHWvYX6gUWNHPyClZXzsd{BjgSCjcoLhfU1j[XOnZDDmcJVwemW|Y3XuZ4Uh[XO|YYmsJGlEPTBiPTCyJO69VS5? NW\5b3ZXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2OVY{PjlpPkG4OlU3OzZ7PD;hQi=>
Sf9 cells MkPWSpVv[3Srb36gZZN{[Xl? Ml;CTY5pcWKrdHnvckBw\iCqdX3hckBUgWtiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{whUUN3MDC9JFAvODB|IN88UU4> NYDhVYpKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4NlM4QDRpPkG4PFI{Pzh2PD;hQi=>
Sf9 cells MkDjSpVv[3Srb36gZZN{[Xl? MkX1TY5pcWKrdHnvckBw\iCqdX3hckBbSVB5MDDlfJBz\XO|ZXSgbY4hW2Z7IHPlcIx{NCCLQ{WwJF0hOC5yNUOg{txONg>? NFG1fJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEiyN|c5PCd-MUi4NlM4QDR:L3G+
insect cells NYfmOGtETnWwY4Tpc44h[XO|YYm= NID1VHhKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDpcVEh\XiycnXzd4VlKGmwIHnud4VkfCClZXzsd{BjgSCKVGLGMEBKSzVyIE2gNE4xOSEQvF2u NYfYVlZuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxO|kxPzZpPkG5NVc6ODd4PD;hQi=>
HT-29 cells MYjBdI9xfG:|aYOgZZN{[Xl? M3zVdVIhcA>? Mo\DTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCKVD2yPUBk\WyuczDhd5Nme3OnZDDhd{BkcGGwZ3WgbY4hdWm2b3Poc45lemmjbDD0doFve22nbXLyZY5mKHCxdHXueIlidCCjZoTldkAzKGi{czDifUBLSzFic4ThbY5qdmdiYnHz[YQh\my3b4Lld4NmdmOnIHHzd4F6NCCHREWwJF0hOC5yMEK2JO69VS5? M1TNclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NEKyNlA3Lz5zOUSyNlIxPjxxYU6=
insect Sf21 cells MkjzSpVv[3Srb36gZZN{[Xl? NWXGUJl{UW6qaXLpeIlwdiCxZjDKRWs{KGW6cILld5Nm\CCrbjDpcpNm[3RiU3[yNUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHLpc5RqdnmuYYTl[EB{fWK|dILheIUheGixc4Doc5J6dGG2aX;uMEBKSzVyIE2gNE4xODZizszNMi=> MmDZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl2MkeyNFMoRjF7NEK3NlA{RC:jPh?=
Jurkat cells NUDIWHhsSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M3fOSmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgTmFMOyCneIDy[ZN{cW6pIFnMNk1{fGmvdXzheIVlKGi3bXHuJGp2emujdDDj[YxteyxiSVO1NEA:KDBwMEexJO69VS5? M{fEUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NEK3NlA{Lz5zOUSyO|IxOzxxYU6=
Jurkat cells M13GNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M17PSGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgTmFMOyCneIDy[ZN{cW6pIHj1cYFvKHKnc4TpcochUnW{a3H0JINmdGy|LDDJR|UxKD1iMD6zNVEh|ryPLh?= NHrib4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUSyO|IxOyd-MUm0NlczODN:L3G+
HUE cells MV;GeY5kfGmxbjDhd5NigQ>? MUC5NEBucW6| NIK0elVKdmirYnn0bY9vKG:oIG\FS2ZTOiCrbjDIWWUh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDWSWdHNWmwZIXj[YQh[XW2b4Doc5NxcG:{eXzheIlwdiC2cnXheIVlKG[xcjC5NEBucW6|IHLl[o9z\SCYRVfGJINp[WyuZX7n[UBjgSCHTFnTRUwhUUN3MDC9JFAvODdizszNMi=> NXvufZZVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxO|AyPjNpPkKwNVcxOTZ|PD;hQi=>
Sf9 cells NGf2e3RHfW6ldHnvckBie3OjeR?= NX\J[4o1PjBibXnudy=> MmjPTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCJU2St[pV{\WRiTlnLJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiYX\0[ZIhPjBibXnud{BjgSC{YXTpc41mfHKrYzDwdo91\WmwIHvpcoF{\SCjc4PhfUwhUUN3MDC9JFIvOyEQvF2u NIHFS|g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEW4NFU2Oid-MkC1PFA2PTJ:L3G+
Sf21 cells NIfJblJHfW6ldHnvckBie3OjeR?= MnLIN|AhfU1? MlXLTY5pcWKrdHnvckBw\iCqdX3hckBEUEt{IHvpcoF{\SCneIDy[ZN{\WRiaX6gbY5{\WO2IGPmNlEh[2WubIOgeZNqdmdicHjvd5Bpdy2FUlXCeIll\SCjczDzeYJ{fHKjdHWgZZQhOzBidV2sJGlEPTBiPTCwMlAzPyEQvF2u NHPpdGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOzOFc6Pid-MkGzN|Q4QTZ:L3G+
Sf21 cells NYTkSpdiTnWwY4Tpc44h[XO|YYm= MnX6N|AhfU1? MkLrTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCLS1utZYxxcGFiZYjwdoV{e2WmIHnuJIlve2WldDDT[lIyKGOnbHzzJJV{cW6pIIDoc5NxcG9vVXzp[4h1NUmtYYDwZWIu[WyyaHGgZZMhe3Wkc4TyZZRmKGG2IEOwJJVONCCLQ{WwJF0hOC5yM{mg{txONg>? MlHXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|M{S3PVYoRjJzM{O0O|k3RC:jPh?=
Sf21 cells M{XCS2Z2dmO2aX;uJIF{e2G7 M{TiO|MxKHWP NULSPXBSUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDJT2su[mW2YTDlfJBz\XO|ZXSgbY4hcW6|ZXP0JHNnOjFiY3XscJMhfXOrbnegdIhwe3Cqbz3VcIlocHRvSXvhdJBiSi2jbIDoZUBieyC|dXLzeJJifGViYYSgN|AhfU1uIFnDOVAhRSByLkS5JO69VS5? MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN|NEe5Okc,OjF|M{S3PVY9N2F-
HeLa cells NYGyb4pHS3m2b4TvfIlkcXS7IHHzd4F6 NWHNbFBUPDhiaB?= NVPyOpVNS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yMECwNFQh|ryPLh?= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN6OEG5NUc,OjF|OEixPVE9N2F-
MCF7 cells M3exRmN6fG:2b4jpZ4l1gSCjc4PhfS=> MWC0PEBp NGeyeHJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjB3IN88UU4> M3\nXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{i4NVkyLz5{MUO4PFE6OTxxYU6=
HT-29 cells MXTGeY5kfGmxbjDhd5NigQ>? NXjjZYpIOiCq NEDzdYJG\m[nY4Sgc44hdWm2b3Poc45lemmjbDDt[Y1jemGwZTDwc5RmdnSrYXygbY4hcHWvYX6gTHQuOjliY3XscJMh[W[2ZYKgNkBpenNidYPpcochUkNvMTDzeIFqdmmwZzDifUBndHWxcnXzZ4Vv[2ViYYPzZZktKEmFNUCgQUAxNjByMjFOwG0v Mo\kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2MkizO|UoRjJzNEK4N|c2RC:jPh?=
HeLa cells M1rOV2N6fG:2b4jpZ4l1gSCjc4PhfS=> M{fsNFQ5KGh? MkfaR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4xODByMESg{txONg>? NYrVPG1qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0PFg3PTVpPkKxOFg5PjV3PD;hQi=>
MCF7 cells Mny1R5l1d3SxeHnjbZR6KGG|c3H5 MXO0PEBp NWXSeY1pS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yNTFOwG0v NYT2So5pRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0PFg3PTVpPkKxOFg5PjV3PD;hQi=>
HT-29 cells MWPGeY5kfGmxbjDhd5NigQ>? NX3sVFRQUW6qaXLpeIlwdiCxZjDtbZRw[2ixbnTybYFtKG2nbXLyZY5mKHCxdHXueIlidCCrbjDoeY1idiCKVD2yPUBk\WyuczD1d4lv\yCMQ{Gg[JlmKHO2YXnubY5oKGK7IH\seY9z\XOlZX7j[UBxdGG2ZTDy[YFl\XJiYYPzZZktKEmFNUCgQUAxNjByMkWg{txONg>? MmW0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3MUOyPVMoRjJzNUGzNlk{RC:jPh?=
SF268 cells MonDR5l1d3SxeHnjbZR6KGG|c3H5 NYPGc3pRPDhiaB?= NF3HOpdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUTjJ4ODDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwJF0hOC5yNESg{txONg>? NXnmN3lwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1NVMzQTRpPkKxOVE{Ojl2PD;hQi=>
CHOK1 cells M{TSVGN6fG:2b4jpZ4l1gSCjc4PhfS=> NETQcWw1QCCq M1u2TGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNJV0tzIHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUAxNjF|IN88UU4> NFj2WJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWxN|I6PCd-MkG1NVMzQTR:L3G+
H460 cells NILKWJBEgXSxdH;4bYNqfHliYYPzZZk> MXi0PEBp MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIOFYxKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTBiPTCzMlYh|ryPLh?= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTVzM{K5OEc,OjF3MUOyPVQ9N2F-
HT-29 cells NITBTYdEgXSxdH;4bYNqfHliYYPzZZk> NELvNZY1QCCq M{TvU2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhVNTJ7IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUA{NjZizszNMi=> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTVzM{K5OEc,OjF3MUOyPVQ9N2F-
MCF7 cells MUPDfZRwfG:6aXPpeJkh[XO|YYm= MmTNOFghcA>? MlnkR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyIE2gNVEh|ryPLh?= NYrkN21URGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1NVMzQTRpPkKxOVE{Ojl2PD;hQi=>
SW1116 cells MmXQSpVv[3Srb36gZZN{[Xl? MV6yOEBp M1LPTWlvcGmkaYTpc44hd2ZidHXsc41memG|ZTDpckBpfW2jbjDTW|EyOTZiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JHRTSVBvUFPSMWVNUVODIHHzd4F6NCCLQ{WwJF0hQC5|MjFOwG0v NVT3emJiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlI2OjNpPkKxPVYzPTJ|PD;hQi=>
HT-29 cells MVvBdI9xfG:|aYOgZZN{[Xl? NUTUboFvOiCq Mo\3TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCKVD2yPUBk\WyuczDhd5Nme3OnZDDy[YR2[3Srb36gc4YhdWm2b3Poc45lemmjbDDt[Y1jemGwZTDwc5RmdnSrYXygZYZ1\XJiMjDodpMh[nlidYPpcochUkNzIIP0ZYlvcW6pIHL5JIZtfW:{ZYPj[Y5k\SClZXzsMYJie2WmIHHzd4F6NCCHREWwJF0hOC5yMEK2JO69VS5? Mn7wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7N{OxNFEoRjJzOUezNVAyRC:jPh?=
LoVo cells NHfJbGdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MVu0PEB1dyB5MjDo NHT5PY5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzvWo8h[2WubIOgZYZ1\XJiNEigeI8hPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMECxJO69VS5? M17D[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUiyPVI6Lz5{MkG4NlkzQTxxYU6=
ST486 cells NEX6V|VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MkTSOFghfG9iN{KgbC=> MkLIRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVVES4OkBk\WyuczDh[pRmeiB2ODD0c{A4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yMEeg{txONg>? Mn\YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzOEK5NlkoRjJ{MUiyPVI6RC:jPh?=
DLD1 cells NWjTflJxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= Mn3JOFghfG9iN{KgbC=> Mk\tRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCGTFSxJINmdGy|IHHmeIVzKDR6IITvJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjByOTFOwG0v NEfoNJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG4NlkzQSd-MkKxPFI6Ojl:L3G+
B16F10 cells NGnzWmRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NUXpU3dwPDhiaB?= Mo\4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCEMU\GNVAh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuPFIh|ryPLh?= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjVyM{O2OEc,OjJ3MEOzOlQ9N2F-
MCF7 cells MXnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MmLKOFghcA>? MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNwMEeg{txONg>? NVm1[oZzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1NFM{PjRpPkKyOVA{OzZ2PD;hQi=>
A431 cells NHnPbWJEgXSxdH;4bYNqfHliYYPzZZk> M{HBN|I1KGh? NXTie49HS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTR|MTDj[YxteyCjZoTldkAzPCCqcoOgeZNqdmdiQX7u[ZhqdiCYZV\JWGMweHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkC3JO69VS5? MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV2MUC1NUc,OjJ3NEGwOVE9N2F-
MCF7 cells M2P0W2N6fG:2b4jpZ4l1gSCjc4PhfS=> NGHBemkzPCCq MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEK0JIhzeyC3c3nu[{BCdm6neHnuJHZmTkmWQz;wdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pIHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOThizszNMi=> NHq1Xmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW0NVA2OSd-MkK1OFExPTF:L3G+
BJ cells MYTDfZRwfG:6aXPpeJkh[XO|YYm= Mme0O|IhcA>? NEHKdHlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDUiClZXzsd{Bi\nSncjC3NkBpenNiYomgR4Ft[2WrbjDBUUBie3OjeTygTWM2OCB;IECuNFAzKM7:TT6= NXuwSHc1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5NlExQDFpPkKyPVIyODhzPD;hQi=>
CEM cells MlTOR5l1d3SxeHnjbZR6KGG|c3H5 NXTmZoF3PzJiaB?= MnnYR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2VOKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDDZYxk\WmwIFHNJIF{e2G7LDDJR|UxKD1iMD6wNlMh|ryPLh?= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl{MUC4NUc,OjJ7MkGwPFE9N2F-
MCF7 cells NELo[5FEgXSxdH;4bYNqfHliYYPzZZk> M{jqTVczKGh? MnLjR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC3NkBpenNiYomgR4Ft[2WrbjDBUUBie3OjeTygTWM2OCB;IECuNFY1KM7:TT6= NFTOUoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmyNVA5OSd-MkK5NlExQDF:L3G+
HeLa cells M3TwXmN6fG:2b4jpZ4l1gSCjc4PhfS=> M2\Yc|czKGh? MmT4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bi\nSncjC3NkBpenNiYomgR4Ft[2WrbjDBUUBie3OjeTygTWM2OCB;IECuNVc2KM7:TT6= NEnr[I49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmyNVA5OSd-MkK5NlExQDF:L3G+
HepG2 cells M1jE[2Z2dmO2aX;uJIF{e2G7 M3[xWVI1KGh? Mke3TY5pcWKrdHnvckBw\iC2ZXzvcYVz[XOnIHnuJIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDUVmFRNVCFUj3FUGlUSSCjc4PhfUwhUUN3MDC9JFQvOTRizszNMi=> NFnBc3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxPFA6Pid-MkOwNVgxQTZ:L3G+
SW1116 cells NYXNUHZxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NVPMOGFCPDhiaB?= NFL6WFZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXNVEyPiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKG2ndHjv[EwhUUN3MDC9JFQvQTVizszNMi=> MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzOEC5Okc,OjNyMUiwPVY9N2F-
HepG2 cells MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M{DLXFQ5KGh? MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgcYV1cG:mLDDJR|UxKD1iNj63N{DPxE1w Mn6wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMUiwPVYoRjJ|MEG4NFk3RC:jPh?=
BGC823 cells MUnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MmfYOFghcA>? NU[wRpVDSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCS2M5OjNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCvZYToc4QtKEmFNUCgQUA3Njh|IN88UU4> MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzOEC5Okc,OjNyMUiwPVY9N2F-
HeLa cells M4i5WWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NVzqVpBVPDhiaB?= NVTZfXJSSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQhdWW2aH;kMEBKSzVyIE2gPU4yOiEQvF2u M{f1ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEG4NFk3Lz5{M{CxPFA6PjxxYU6=
HCT116 cells M4DzSGZ2dmO2aX;uJIF{e2G7 MkHNTY5pcWKrdHnvckBw\iCWTlnLMY1m\GmjdHXkJHRETjRxYnX0ZU1k[XOnaX6geJJidnOlcnnweIlwdiCrbjDoeY1idiCKQ2SxNVYh[2WubIOgZpkh[mW2YT3sZYN1[W2jc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3MDC9JFAvODN7IN88UU4> NHH5emY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{KzNlA3OCd-MkOyN|IxPjB:L3G+
HepG2 cells NVLKNJBCTnWwY4Tpc44h[XO|YYm= NUCwNZlJPDhiaB?= MkDiTY5pcWKrdHnvckBw\iC2ZXzvcYVz[XOnIHnuJIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDUVmFRNVCFUj3FUGlUSSxiSVO1NEA:KDhwMzFOwG0v MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ5OUi2OEc,OjN{N{m4OlQ9N2F-
SW1116 cells MofLSpVv[3Srb36gZZN{[Xl? NHzQ[mkzPCCq NYX5O2RLUW6qaXLpeIlwdiCxZjD0[YxwdWW{YYPlJIlvKGi3bXHuJHNYOTFzNjDj[YxteyCjZoTldkAzPCCqcoOgZpkhXFKDUD3QR3IuTUyLU1GgZZN{[XluIFnDOVAhRSB2LkG4JO69VS5? M3v6RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Mki2O|YyLz5{NEK4Olc3OTxxYU6=
KE-97 cells M2nRfWN6fG:2b4jpZ4l1gSCjc4PhfS=> MnXxO|IhcA>? NUnhSXd2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hU0VvOUegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRz\S2JbH:gcJVucW6nc3PlcpQh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSByLkGzJO69VS5? MlPHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|MkiyPFMoRjJ2M{K4Nlg{RC:jPh?=
Jurkat cells NEfuWVlEgXSxdH;4bYNqfHliYYPzZZk> MUe3NkBp NFHpc5JEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBLfXKtYYSgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRz\S2JbH:gcJVucW6nc3PlcpQh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSByLkG0JO69VS5? MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN{OEK4N{c,OjR|MkiyPFM9N2F-
HuH7 cells M{LwSmN6fG:2b4jpZ4l1gSCjc4PhfS=> MX23NkBp NHzEZmxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJfUh5IHPlcIx{KGGodHXyJFczKGi{czDifUBE\WyuVHn0doUuT2yxIHz1cYlv\XOlZX70JINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOC5{MzFOwG0v MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN{OEK4N{c,OjR|MkiyPFM9N2F-
BGC823 cells MYTDfZRwfG:6aXPpeJkh[XO|YYm= MnfTO|IhcA>? NXvzOFNrS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSkeFOEKzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1emVvR3zvJIx2dWmwZYPj[Y51KGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMD6zPEDPxE1w NWX4WlJ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzNlgzQDNpPkK0N|I5Ojh|PD;hQi=>
MCF7 cells NXTSPHdiS3m2b4TvfIlkcXS7IHHzd4F6 M1qye|czKGh? M{Xzd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTy[U1IdG9ibIXtbY5me2OnboSgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAxNjV{IN88UU4> MnHyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|MkiyPFMoRjJ2M{K4Nlg{RC:jPh?=
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A2780 cells NIDVV3hEgXSxdH;4bYNqfHliYYPzZZk> NH[3RmI6PiCq NYn6TpN5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTJ5OECgZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDBwMjFOwG0v MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN4MUWyNUc,OjR|NkG1NlE9N2F-
HT-29 cells NVzwSZl5S3m2b4TvfIlkcXS7IHHzd4F6 NX;GZYxyQTZiaB?= NHHtTWxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOC5{IN88UU4> NVfOUlduRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOlE2OjFpPkK0N|YyPTJzPD;hQi=>
8505C cells MX;DfZRwfG:6aXPpeJkh[XO|YYm= MYK5OkBp MoHyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gPFUxPUNiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFAvOiEQvF2u NUL1[5dWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOlE2OjFpPkK0N|YyPTJzPD;hQi=>
518A2 cells M13hNWN6fG:2b4jpZ4l1gSCjc4PhfS=> MmfFPVYhcA>? NV7IXJNvS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hPTF6QUKgZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDBwMjFOwG0v M{\3ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{[xOVIyLz5{NEO2NVUzOTxxYU6=
MCF7 cells M3XTZWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUfEe|FXQTZiaB?= NW\teXA4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOC52IN88UU4> NWHOTJpDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOlE2OjFpPkK0N|YyPTJzPD;hQi=>
A549 cells MXjDfZRwfG:6aXPpeJkh[XO|YYm= NH7jeIQ6PiCq NEfkPWhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUAxNjZizszNMi=> MkD2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|NkG1NlEoRjJ2M{[xOVIyRC:jPh?=
V79 MZ cells NUn1OIxxTnWwY4Tpc44h[XO|YYm= NIjU[IdKdmirYnn0bY9vKG:oIHj1cYFvKGGuZH;zeIVzd26nIIP5cpRp[XOnIHX4dJJme3OnZDDpckBXPzliTWqgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCjbHTvd5Rmem:wZTDzfY51cGW|aYOsJGlEPTBiPTCwMlAyOSEQvF2u M3uycFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEKyOVE6Lz5{NESyNlUyQTxxYU6=
HEK293 cells NGjnXmREgXSxdH;4bYNqfHliYYPzZZk> MWe3NkBp MmX5R5l1d3SxeHnjbZR6KGGpYXnud5QhUEWNMkmzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XKJbH:gZZN{[XluIFnDOVAhRSByLkC1OkDPxE1w M3vyWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{[zNlYzLz5{NEe2N|I3OjxxYU6=
HeLa cells MnToRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MlLwNlQhfG9iNEigbC=> NYnRbWNkSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IEK0JJRwKDR6IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IEKuO|Ih|ryPLh?= M4rENVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{myPFEyLz5{NEe5NlgyOTxxYU6=
A549 cells MULBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NEXsbZYzPCC2bzC0PEBp MkDyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDJ2IITvJFQ5KGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDNwMEWg{txONg>? NYLyVXhZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3PVI5OTFpPkK0O|kzQDFzPD;hQi=>
HepG2 cells NVj3XnNyS3m2b4TvfIlkcXS7IHHzd4F6 NHHL[XdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyxiRVO1NEA:KDJizszNMi=> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTNzNkOxO{c,OjV|MU[zNVc9N2F-
Raji cells MlHCR5l1d3SxeHnjbZR6KGG|c3H5 M{PDWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHJicmliY3XscJMtKEWFNUCgQUAzKM7:TT6= M2DqUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{G2N|E4Lz5{NUOxOlMyPzxxYU6=
BJ cells MoDuR5l1d3SxeHnjbZR6KGG|c3H5 MmfiR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRmoh[2WubIOsJGVEPTBiPTCyJO69VS5? MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTNzNkOxO{c,OjV|MU[zNVc9N2F-
HEK293 cells Ml7GR5l1d3SxeHnjbZR6KGG|c3H5 MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBJTUt{OUOgZ4VtdHNuIFXDOVAhRSB{IN88UU4> MnzTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|MU[zNVcoRjJ3M{G2N|E4RC:jPh?=
A549 cells MX\DfZRwfG:6aXPpeJkh[XO|YYm= MXS0PEBp M4HNWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODJizszNMi=> M2nqNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEK1PVM1Lz5{NUiyOVk{PDxxYU6=
HeLa cells Ml63R5l1d3SxeHnjbZR6KGG|c3H5 MWS0PEBp NGjvPGZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjB{NTFOwG0v NGezNmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUiyOVk{PCd-MkW4NlU6OzR:L3G+
PC3 cells MmT6R5l1d3SxeHnjbZR6KGG|c3H5 MnvWOFghcA>? NF33OmpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODNzIN88UU4> M3;ZfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEK1PVM1Lz5{NUiyOVk{PDxxYU6=
MGC-803 cells NFqwN4NHfW6ldHnvckBie3OjeR?= MUGyOEBp M3rDb2lvcGmkaYTpc44hd2ZidHXsc41memG|ZTDpckBpfW2jbjDNS2MuQDB|IHPlcIx{KGGodHXyJFI1KGi{czDifUBVWkGSLWDDVk1GVEmVQTDhd5NigSxiSVO1NEA:KDhwOUeg{txONg>? NYfneIxDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[5NFA3PTZpPkK2PVAxPjV4PD;hQi=>
Sf9 insect cells MkfTSpVv[3Srb36gZZN{[Xl? MWqxNEBucW6| MoLDTY5pcWKrdHnvckBw\iCQLYTldo1qdmGuIFfTWEB1[WepZXSgdoVkd22kaX7hcpQh\nWubD3s[Y5ofGhiaIXtZY4hS0iNMTDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiU3[5JIlve2WldDDj[YxteyCjZoTldkAyOCCvaX7zJIJ6KGy3bXnu[ZNk\W62IFHEVE1IdG9iYYPzZZktKEmFNUCgQUAxNjByMUKg{txONg>? M1HITFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEi5NlEyLz5{N{C4PVIyOTxxYU6=
Sf21 cells MYPGeY5kfGmxbjDhd5NigQ>? NVrMdFNQPjBibXnudy=> NInPZlRKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFrBT|Ih\XiycnXzd4VlKGmwIGPmNlEh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIGXsbYdpfC2FQVfBS2FKTVSGS1XZXXRXU0RicHjvd5Bpd3K7bHH0bY9vKHC{ZT3pcoN2[mG2ZXSgZoVnd3KnIIP1ZpN1emG2ZTDh[IRqfGmxbjDhcoQhdWWjc4Xy[YQh[W[2ZYKgOlAhdWmwczDifUBNSU6FRTDk[ZRm[3Srb36gcYV1cG:mLDDJR|UxKD1iMD6wNFIh|ryPLh?= M13udFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUO3N|U6Lz5{N{GzO|M2QTxxYU6=
Neuro2a cells NVnqSVh3S3m2b4TvfIlkcXS7IHHzd4F6 MXq3NkBp NFPQUnFEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBP\XW{b{LhJINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkCxNVMh|ryPLh?= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF3MkSyO{c,OjhzNUK0Nlc9N2F-
MDA-MB-231 cells M3zobGZ2dmO2aX;uJIF{e2G7 Mn[xNVYhcA>? MoS3TY5pcWKrdHnvckBw\iC{ZYTpco9jdGG|dH;tZUBxem:2ZXnuJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDF4IHjyd{BjgSCKb3XjbJN1KDN|M{SyJJN1[WmwaX7nJIJie2WmIH\seY9z\XOlZX7j[UBie3OjeTygTWM2OCB;IECuNFY3KM7:TT6= NGHGNY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OESzNVM1Oid-Mki0N|E{PDJ:L3G+
Sf9 insect cells MYjGeY5kfGmxbjDhd5NigQ>? NGG0R2kzOCCvaX7z MVHJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IHj1cYFvKE5vdHXycYlv[WyueTDHV3QufGGpZ3XkJGVITlJiTEi1PHIwXDd7MF2vR|c6P1NidILpdIxmKG23dHHueEBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOgbY4hW2Z7IHnud4VkfCClZXzsd{BxemWrbnP1ZoF1\WRiZn;yJFIxKG2rboOg[o9tdG:5ZXSgZpkh[WSmaYTpc44hd2ZiW{OzVH0uSVSSIH3lZZN2emWmIHHmeIVzKDJiaILzJIJ6KG[rbITldk1jcW6maX7nJI1mfGixZDygTWM2OCB;IECuNFAxOjlizszNMi=> Mmr3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2OEKxOVEoRjJ6NEiyNVUyRC:jPh?=
HEK293 cells NH;ZUZpEgXSxdH;4bYNqfHliYYPzZZk> Ml;5O|IhcA>? M{\QVmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyJGdtdyCudX3pcoV{[2WwdDDhd5NigSxiQ1O1NEA:KDBwMECzOVQh|ryPLh?= M1rxZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkK0O|AyLz5{OE[yOFcxOTxxYU6=
BT549 cells MoP3R5l1d3SxeHnjbZR6KGG|c3H5 NVnOc4hEOjRiaB?= NHvBcJJEgXSxdH;4bYMh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCWFU1QSClZXzsd{BqdmO3YnH0[YQh\m:{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlA5KM7:TT6= NGS0c5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEewOVQ{Oid-Mki3NFU1OzJ:L3G+
MDA-MB-468 cells NF\6W4JEgXSxdH;4bYNqfHliYYPzZZk> NV;0VnhlOjRiaB?= NH;hR4tEgXSxdH;4bYMh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNE[4JINmdGy|IHnuZ5Vj[XSnZDDmc5IhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMUWg{txONg>? MmDNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5MEW0N|IoRjJ6N{C1OFMzRC:jPh?=
MDA-MB-231 cells NV\DUnVLS3m2b4TvfIlkcXS7IHHzd4F6 MUKyOEBp NELvbolEgXSxdH;4bYMh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHnuZ5Vj[XSnZDDmc5IhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMkSg{txONg>? M2TqS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{C1OFMzLz5{OEewOVQ{OjxxYU6=
Vero cells NEn6WVdEgXSxdH;4bYNqfHliYYPzZZk> MWCyJIRigXN? NUfLO3FXS3m2b4TvfIlkcXS7IHHnZYlve3RiQX\ybYNidiCpcnXlckBud26tZYmgWoVzdyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOiCmYYnzJIJ6KGOnbHyteIl1\XJvZ3zvJIx2dWmwZYPj[Y51KGG|c3H5MEBVSzVyIE2gNE4xODJ2IN88UU4> NU\wR4ZtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OlM3PDVpPkK4O|Y{PjR3PD;hQi=>
L929 cells NF\6ZZhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M{DyOlUh\GG7cx?= NGrxUWtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFy5Nlkh[2WubIOgZYZ1\XJiNTDkZZl{KGK7IGfTWE0yKGG|c3H5MEBKSzVyIE2gNE4zKM7:TT6= Mm\0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7NU[5NVUoRjJ6OUW2PVE2RC:jPh?=
KB-3-1 cells NWjne2s2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NUX5cIp[PSCmYYnz NFnDSHdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFvCMVMuOSClZXzsd{Bi\nSncjC1JIRigXNiYomgW3NVNTFiYYPzZZktKEmFNUCgQUAxNjJizszNMi=> NVLwUZJ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5OVY6OTVpPkK4PVU3QTF3PD;hQi=>
MCF7 cells MXfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M373RVUh\GG7cx?= NFT6VlNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiNTDkZZl{KGK7IGfTWE0yKGG|c3H5MEBKSzVyIE2gNU45KM7:TT6= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl3NkmxOUc,Ojh7NU[5NVU9N2F-
FS4-LTM cells NEfSVIhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= Mm\zNlQhcA>? M3zZNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRmO0MWxVVSClZXzsd{Bi\nSncjCyOEBpenNiYomgW3NVNTFiYYPzZZktKEmFNUCgQUAzNjhizszNMi=> M1zQOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUW2PVE2Lz5{OEm1OlkyPTxxYU6=
Vero cells NUfMSIlZS3m2b4TvfIlkcXS7IHHzd4F6 MWKyJIRigXN? MUXDfZRwfG:6aXPpeJkh[WejaX7zeEBC\nKrY3HuJIdz\WWwIH3vcotmgSCYZYLvJINmdGy|IHHmeIVzKDJiZHH5d{BjgSCFZXzsWIl1\XJvR3zvJIx2dWmwZYPj[Y51KGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMD6wNFI1KM7:TT6= M2jUcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUmzNVA3Lz5{OEm5N|ExPjxxYU6=
HepG2 cells M3O4O2N6fG:2b4jpZ4l1gSCjc4PhfS=> MXWxNFAhfU1? NHK0[2g{KGSjeYO= NIHpZW1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjdDCxNFAhfU1iYX\0[ZIhOyCmYYnzJIJ6KEOnbHzUbZRmei2JbH:gcJVucW6nc3PlcpQh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSByLkCxPEDPxE1w NHXte2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm5N|ExPid-Mki5PVMyODZ:L3G+
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A549 cells MXTDfZRwfG:6aXPpeJkh[XO|YYm= MY[5OkBp MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGVEPTBiPTCwMlA1KM7:TT6= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF7N{ezNEc,OjlzOUe3N|A9N2F-
MCF7 cells NX:3Rpl1S3m2b4TvfIlkcXS7IHHzd4F6 MUi5OkBp M4DOT2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgPVYhcHK|IHL5JHNTSiCjc4PhfUwhTUN3MDC9JFAvOSEQvF2u NVvMVHd7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxPVc4OzBpPkK5NVk4PzNyPD;hQi=>
A2780 cells M1TGNWN6fG:2b4jpZ4l1gSCjc4PhfS=> MlPRPVYhcA>? NWLTVGVpS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTJ5OECgZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KFOUQjDhd5NigSxiRVO1NEA:KDBwMUKg{txONg>? NGTVdoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUG5O|c{OCd-MkmxPVc4OzB:L3G+
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Assay
Methods Test Index PMID
Western blot FAK / RIP p-Akt / Akt / PARP /Cleaved PARP Ambra1 15121855 24174874 24587252
Growth inhibition assay Cell viability 25215174
Immunofluorescence Phalloidin / Type II collagen Tubulin / Actin FAK 4.47 cleaved-caspase 3 Annexin Pyk2 22684244 25215174 15121855 19840952 15140398 19880522
体内研究 在局部贫血前,使用Staurosporine(0.1-10 ng)预处理局部贫血沙鼠和大鼠模型,可防止神经元损伤,这种作用存在剂量依赖性,说明CAl锥体细胞死亡涉及PKC。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

  • Enzyme assay and binding assay:

    Protein kinase C is assayed in a reaction mixture (0.25 mL) containing 5 μmol of Tris/HCl, pH 7.5, 2.5 μmol of magnesium acetate, 50 μg of histone II S, 20 μg of phosphatidylserine, 0.88 μg of diolein, 125 nmol of CaCl2, 1.25 nmol of [γ-32]ATP (5-10 × 104 cpm/nmol) and 5 μg of partially purified enzyme. The binding of [3H]PDBu to protein kinase C is determined: Reaction mixture (200 μL contained 4 μmo1 of Tris/malate, pH 6.8, 20 μmol of KCl, 30 nmol of CaC12, 20 μg of phosphatidylserine, 5 μg of partially purified protein kinase C, 0.5% (final concentration) of DMSO,10 pmol of [3H]PDBu (l-3 × 104 cpm/pmol) and 10 μL of various amounts of Staurosporine.

细胞实验:[4]
  • Cell lines: PC12
  • Concentrations: 溶于DMSO,终浓度为1 μM
  • Incubation Time: ~32 小时
  • Method: 使用Staurosporine处理细胞32小时。细胞在4%多聚甲醛中混合,然后使用DNA结合染料Hoechst 33342染色。在荧光照明下观察细胞,测定凋亡细胞百分数。
动物实验:[2]
  • Animal Models: 短暂局部贫血的雄性Mongolian沙鼠或雄性 Wistar大鼠
  • Dosages: ~10 ng
  • Administration: 定向处理到海马双边CA1子域

溶解度(25°C)

体外

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 466.53
化学式

C28H26N4O3

CAS号 62996-74-1
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

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