BX-795

For research use only. Not for use in humans.

目录号：S1274

CAS No. 702675-74-9

BX-795 是一种有效的，特异性的PDK1抑制剂，在无细胞试验中IC50为6 nM，作用于PDK1比作用于PKA和PKC选择性分别高140和1600倍。同时，相比于 GSK3β，作用于PDK1的选择性高出100多倍。BX-795 可通过抑制 ULK1 来调节自噬。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 1628.91	现货
10mg	RMB 1236.66	现货
25mg	RMB 2623.21	现货
50mg	RMB 4662.25	现货
100mg	RMB 7931.08	现货
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全国免费电话：400-668-6834 | Email：info@selleck.cn

客户使用Selleck生产的BX-795发表文献41篇：

Nature, 2019, 567(7747):262-266

PubMed: 30842662 ( click the link to review the publication )

Cell, 2019, 176(6):1447-1460

PubMed: 30799039 ( click the link to review the publication )

Science, 2015, 13;347(6227):aaa2630.

PubMed: 25636800 ( click the link to review the publication )

J Thromb Haemost, 2020, 10.1111/jth.14748

PubMed: 31997536 ( click the link to review the publication )

Antimicrob Agents Chemother, 2020, AAC.00245-20

PubMed: 32601167 ( click the link to review the publication )

Oral Dis, 2020, 10.1111/odi.13583

PubMed: 32730654 ( click the link to review the publication )

Cell Death Differ, 2020, 10.1038/s41418-020-0588-y

PubMed: 32678307 ( click the link to review the publication )

iScience, 2020, 23(7):101257

PubMed: 32599557 ( click the link to review the publication )

Cell Rep, 2020, 32(5):107983

PubMed: 32755577 ( click the link to review the publication )

Ocul Surf, 2019, 10.1016/j.jtos.2019.11.011

PubMed: 31770600 ( click the link to review the publication )

Cell Rep, 2019, 27(2):631-647

PubMed: 30970263 ( click the link to review the publication )

Cancer Lett, 2019, 466:23-34

PubMed: 31521695 ( click the link to review the publication )

J Leukoc Biol, 2019, 106(6):1325-1335

PubMed: 31509298 ( click the link to review the publication )

Int J Mol Sci, 2019, 20(3)

PubMed: 30717477 ( click the link to review the publication )

Cancer Med, 2019, 8(5):2380-2391

PubMed: 30993888 ( click the link to review the publication )

Int Immunopharmacol, 2019, 77:105914

PubMed: 31634789 ( click the link to review the publication )

Nat Immunol, 2019, 20(1):18-28

PubMed: 30510222 ( click the link to review the publication )

Cell Death Dis, 2018, 9(7):747

PubMed: 29970878 ( click the link to review the publication )

J Thromb Haemost, 2018, 16(6):1211-1225

PubMed: 29575487 ( click the link to review the publication )

Endocrinology, 2018, 159(1):285-296

PubMed: 29029116 ( click the link to review the publication )

Vet Microbiol, 2018, 227:61-68

PubMed: 30473353 ( click the link to review the publication )

Cell Death Dis, 2018, 9(3):269

PubMed: 29449645 ( click the link to review the publication )

Blood Adv, 2018, 2(23):3428-3442

PubMed: 30504235 ( click the link to review the publication )

Nucleic Acids Res, 2017, 45(20):11622-11642

PubMed: 28977426 ( click the link to review the publication )
Nucleic Acids Res, 2017, 45(16):9654-9678

PubMed: 28934469 ( click the link to review the publication )

Sci Rep, 2017, 7(1):982

PubMed: 28428627 ( click the link to review the publication )

Front Cell Infect Microbiol, 2017, 7:169

PubMed: 28529930 ( click the link to review the publication )

Nat Commun, 2016, 7:11363

PubMed: 27193833 ( click the link to review the publication )

Cancer Discov, 2016, 6(10):1134-1147

PubMed: 27604488 ( click the link to review the publication )

J Immunol, 2016, 196(5):2272-82

PubMed: 26826240 ( click the link to review the publication )

J Biol Chem, 2016, 291(20):10904-15

PubMed: 27002159 ( click the link to review the publication )

Tissue Eng Part A, 2016, 22(17-18):1075-85

PubMed: 27477105 ( click the link to review the publication )

Front Cell Infect Microbiol, 2016, 6:182

PubMed: 28018864 ( click the link to review the publication )

PLoS One, 2016, 11(5):e0155052

PubMed: 27148873 ( click the link to review the publication )

Am J Reprod Immunol, 2016, 75(4):451-60

PubMed: 26892235 ( click the link to review the publication )

Am J Reprod Immunol, 2016, 76(5):348-357

PubMed: 27613665 ( click the link to review the publication )

J Biomol Screen, 2016, 10.1177/1087057116656314

PubMed: 27358388 ( click the link to review the publication )

Proc Natl Acad Sci USA, 2014, 111(49):17438-43

PubMed: 25326420 ( click the link to review the publication )

FEBS J, 2014, 281(17):3816-27

PubMed: 25040165 ( click the link to review the publication )

Virology, 2014, 450-451:182-95

PubMed: 24503081 ( click the link to review the publication )

PLoS One, 2014, 9(11):e112014

PubMed: 25390891 ( click the link to review the publication )

产品安全说明书

PDK抑制剂选择性比较

生物活性

产品描述

靶点

PDK-1 ^[1] (Cell-free assay)	c-Kit ^[1] (Cell-free assay)	CDK2/CyclinE ^[1] (Cell-free assay)	Chk1 ^[1] (Cell-free assay)
6 nM	320 nM	430 nM	510 nM

体外研究

BX795也抑制MARK1,MARK2,MARK4,NUAK1,VEGFR,MLK1,MLK2,和MLK3，IC50分别为55,53,19,5,157,50,46和42 nM。1 μM BX795不抑制如下酪氨酸蛋白激酶: 肝配蛋白受体A2和B3,Syk,Bruton's酪氨酸激酶,和FGFR1。然而，BX795抑制VEGFR，抑制效果比TBK1低。BX795抑制TBK1-催化的IRF3在Ser396位点磷酸化随着ATP浓度上升而下降,说明BX795是ATP竞争性抑制剂。BX795阻断TBK1和IKKε调节的IRF3激活，且抑制IFN-β的产量。聚(I:C)处理后，IRF3在核中积累，但是可被BX795抑制。 BX795抑制IRF3依赖的基因转录。BX795抑制IFN-β从巨噬细胞中分泌。BX795对LPS刺激的p70核糖体S6激酶1在Thr229位点磷酸化没有效果, Thr229位点是PDK1作用靶点。BX795不影响IKKα/β复合体或LPS,聚(I:C),IL-1α,或TNFα促进的NFκB依赖的基因转录的激活。BX795作用于IL-1α或TNFα刺激的MEFs，也阻断JNK1/2和p38α MAPK磷酸化。BX795抑制TBK1/IKKε不会导致JNK1/2和p38α MAPK的激活。^[1]

Cell Data

Cell Lines	Assay Type	Incubation Time	Activity Description	PMID
human MV-4-11 cell	Mmn1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		M1zCNGlvcGmkaYTpc44hd2ZiaIXtZY4hVVZvND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM3Njhibl2=	NXfLXmN5W0GQR1XS
KRX cells	NFvsdWtHfW6ldHnvckBie3OjeR?=	MmXVO{BucW6\|	NYrnPYRyUW6qaXLpeIlwdiCxZjDTWW1QNXSjZ3fl[EBWVEtzIDj1cotvd3ewIH;ybYdqdilia3nuZZNmKGSxbXHpckBmgHC{ZYPz[YQhcW5iS2LYJINmdGy\|IIXzbY5oKFt\|MmDdMYdidW2jLVHUVEBidmRibYnlcIlvKGKjc3njJJBzd3SnaX6gd5Vje3S{YYTlJIlv[3WkYYTl[EBnd3JiNzDtbY5{	MljqNlYzPzV4OEG=
human NKM-1 cell	NIDWZ4dIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MWHJcohq[mm2aX;uJI9nKGi3bXHuJG5MVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MD6zOlE6PCEQvF2=	MYXTRW5ITVJ?
human P30-OHK cell	MnLTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NIrJWWdKdmirYnn0bY9vKG:oIHj1cYFvKFB\|MD3PTGsh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTygTWM2OD1yLkS5OlUh\|ryP	MmTWV2FPT0WU
human YH-13 cell	NYXQOJVST3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NGe1dnFKdmirYnn0bY9vKG:oIHj1cYFvKFmKLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE43Ojh6ODFOwG0>	NXr2NZVrW0GQR1XS
human LXF-289 cell	M1qycWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NF72O4lKdmirYnn0bY9vKG:oIHj1cYFvKEy[Rj2yPFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS5iSVO1NF0xNjZ3NkmzJO69VQ>?	MmLDV2FPT0WU
human BE-13 cell	M17HSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MlexTY5pcWKrdHnvckBw\iCqdX3hckBDTS1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUCuO\|A1PzdizszN	MUPTRW5ITVJ?
human RS4-11 cell	M13LbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NWWxWIloUW6qaXLpeIlwdiCxZjDoeY1idiCUU{StNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjd{NUm0JO69VQ>?	MmfkV2FPT0WU
human A3-KAW cell	MlKxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		M33HbGlvcGmkaYTpc44hd2ZiaIXtZY4hSTNvS1HXJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44OzB3NTFOwG0>	M4TzNnNCVkeHUh?=
human PA-1 cell	NITHRlBIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MUTJcohq[mm2aX;uJI9nKGi3bXHuJHBCNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkiwOFIzKM7:TR?=	NEPMVZZUSU6JRWK=
human ES7 cell	M1jJZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NIn6[XVKdmirYnn0bY9vKG:oIHj1cYFvKEWVNzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUCuPFM2PjZizszN	MmOyV2FPT0WU
human ES8 cell	NFfqS5pIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NYf4SlBKUW6qaXLpeIlwdiCxZjDoeY1idiCHU{igZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg1OzN4IN88US=>	MmPvV2FPT0WU
human SW982 cell	M4HjUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		M3XwbmlvcGmkaYTpc44hd2ZiaIXtZY4hW1d7OEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlk2OTJ2IN88US=>	MkjHV2FPT0WU
human VA-ES-BJ cell	MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MUjJcohq[mm2aX;uJI9nKGi3bXHuJHZCNUWVLVLKJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE46QDR4NzFOwG0>	NFGxSZlUSU6JRWK=
human 697 cell	NGfM[olIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		M{fIdGlvcGmkaYTpc44hd2ZiaIXtZY4hPjl5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MT6wNVYzOyEQvF2=	M3Xa[XNCVkeHUh?=
human MOLT-4 cell	MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MnvhTY5pcWKrdHnvckBw\iCqdX3hckBOV0yWLUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA{OjR2IN88US=>	MX3TRW5ITVJ?
human D-283MED cell	M4OyUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NUfUcHN[UW6qaXLpeIlwdiCxZjDoeY1idiCGLUK4N21GTCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTFwMEO5OFgh\|pyv	MVHTRW5ITVJ?
human ALL-PO cell	NUnQZY9xT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		M{m3eWlvcGmkaYTpc44hd2ZiaIXtZY4hSUyOLWDPJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xPjB5MzFOwG0>	M{DMOnNCVkeHUh?=
human NB14 cell	MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MWnJcohq[mm2aX;uJI9nKGi3bXHuJG5DOTRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkC2NFgyKM7:TR?=	M2nMSHNCVkeHUh?=
human NTERA-S-cl-D1 cell	NE\nTplIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NWjTOWZjUW6qaXLpeIlwdiCxZjDoeY1idiCQVFXSRU1UNWOuLVSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xPzd5NTFOwG0>	MXLTRW5ITVJ?
human BFTC-905 cell	M{TKUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NXr6SGFkUW6qaXLpeIlwdiCxZjDoeY1idiCERmTDMVkxPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTFwMEixNFEh\|ryP	NXvZTo9pW0GQR1XS
human H4 cell	NXXJU5JTT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NHvkXldKdmirYnn0bY9vKG:oIHj1cYFvKEh2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MT6xNFIxOSEQvF2=	MofyV2FPT0WU
human CHP-212 cell	NVLLZXh1T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NFv4S21KdmirYnn0bY9vKG:oIHj1cYFvKEOKUD2yNVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjF2MEO3JO69VQ>?	MnTuV2FPT0WU
human A204 cell	NF7zRlNIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NWjkW\|VmUW6qaXLpeIlwdiCxZjDoeY1idiCDMkC0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPTR4NzFOwG0>	NUn2fmZ3W0GQR1XS
human NB69 cell	NUC2OJlOT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NE\zNYJKdmirYnn0bY9vKG:oIHj1cYFvKE6ENkmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE2QDZ3IN88US=>	MnjjV2FPT0WU
human P12-ICHIKAWA cell	NGnPN2lIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MXfJcohq[mm2aX;uJI9nKGi3bXHuJHAyOi2LQ1jJT2FYSSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTFwMUixO\|Eh\|ryP	MVnTRW5ITVJ?
human L-363 cell	NGfGWYxIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MUnJcohq[mm2aX;uJI9nKGi3bXHuJGwuOzZ\|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MT6xPFE6PyEQvF2=	NVjuemZIW0GQR1XS
human ES5 cell	NFKy[W1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=		M1LWN2lvcGmkaYTpc44hd2ZiaIXtZY4hTVN3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MT6xPVM2PCEQvF2=	NE\u[IlUSU6JRWK=
human CAL-51 cell	NETiTJVIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		M4P1bWlvcGmkaYTpc44hd2ZiaIXtZY4hS0GOLUWxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zOjF3NjFOwG0>	Mof4V2FPT0WU
human NBsusSR cell	NVOyPFFpT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		M{LRRmlvcGmkaYTpc44hd2ZiaIXtZY4hVkK\|dYPTVkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjR3N{ig{txO	MUnTRW5ITVJ?
human HOP-92 cell	NH3keVlIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MnG2TY5pcWKrdHnvckBw\iCqdX3hckBJV1BvOUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI4Ojl\|IN88US=>	NUjP[Fc{W0GQR1XS
human DU-4475 cell	MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NYC2eopqUW6qaXLpeIlwdiCxZjDoeY1idiCGVT20OFc2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5{OUK0OUDPxE1?	NGf1Z\|lUSU6JRWK=
human LB1047-RCC cell	NVThVoNKT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		M1PJRWlvcGmkaYTpc44hd2ZiaIXtZY4hVEJzMES3MXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTFwMkmyPFEh\|ryP	M4m5e3NCVkeHUh?=
human D-566MG cell	M2exRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NFPhcpBKdmirYnn0bY9vKG:oIHj1cYFvKERvNU[2UWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjNyNES4JO69VQ>?	MofaV2FPT0WU
human A375 cell	NWfldnB3T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NWHqfo53UW6qaXLpeIlwdiCxZjDoeY1idiCDM{e1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{ODh3ODFOwG0>	M3y4PXNCVkeHUh?=
human ATN-1 cell	NFjI[YZIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NHvVUW9KdmirYnn0bY9vKG:oIHj1cYFvKEGWTj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{PzF6NTFOwG0>	MUHTRW5ITVJ?
human M059J cell	NUL1NJoyT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MVPJcohq[mm2aX;uJI9nKGi3bXHuJG0xPTmMIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MT6zO\|Y2OiEQvF2=	Mk\VV2FPT0WU
human HSC-3 cell	NYfQWXp[T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NHT2N3RKdmirYnn0bY9vKG:oIHj1cYFvKEiVQz2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41PDJyODFOwG0>	NUPkdXRWW0GQR1XS
human DOHH-2 cell	NHzxWGNIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MkfaTY5pcWKrdHnvckBw\iCqdX3hckBFV0iKLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ2QDF2IN88US=>	MXLTRW5ITVJ?
human G-402 cell	MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		M3jvN2lvcGmkaYTpc44hd2ZiaIXtZY4hTy12MEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ3PTJ3IN88US=>	NYXXdJBpW0GQR1XS
human LC-2-ad cell	NHjR[ZdIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NWDvbFI5UW6qaXLpeIlwdiCxZjDoeY1idiCOQz2yMYFlKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS52N{GzNkDPxE1?	NWL0NohDW0GQR1XS
human LOXIMVI cell	MmfoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NEj6XJJKdmirYnn0bY9vKG:oIHj1cYFvKEyRWFnNWmkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjVyNUWyJO69VQ>?	M4XxT3NCVkeHUh?=
human DK-MG cell	MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MnvGTY5pcWKrdHnvckBw\iCqdX3hckBFUy2PRzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUGuOVczQThizszN	MX3TRW5ITVJ?
human HOS cell	NFrScnFIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NV31cIF{UW6qaXLpeIlwdiCxZjDoeY1idiCKT2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU4OzB7IN88US=>	M1m0eHNCVkeHUh?=
human BHT-101 cell	NV;z[lhbT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NVnCUpRbUW6qaXLpeIlwdiCxZjDoeY1idiCESGStNVAyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS53N{i3O{DPxE1?	MWXTRW5ITVJ?
human U-2-OS cell	NGfjPWhIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		M{TYS2lvcGmkaYTpc44hd2ZiaIXtZY4hXS1{LV;TJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42QDhyNjFOwG0>	NE\0W2VUSU6JRWK=
human D-423MG cell	MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NXLSZmdbUW6qaXLpeIlwdiCxZjDoeY1idiCGLUSyN21IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS54MEiwOkDPxE1?	MXPTRW5ITVJ?
human AN3-CA cell	MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NVniZ4F4UW6qaXLpeIlwdiCxZjDoeY1idiCDTkOtR2Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjZ\|OUmxJO69VQ>?	MknCV2FPT0WU
human TE-11 cell	MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		Mkf5TY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUGuOlUzQCEQvF2=	MUTTRW5ITVJ?
human SK-NEP-1 cell	NVjqR5VJT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NWrKWnF[UW6qaXLpeIlwdiCxZjDoeY1idiCVSz3OSXAuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTFwNkWzO\|Yh\|ryP	NHHhdmtUSU6JRWK=
human MG-63 cell	MknBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NXfmeFU4UW6qaXLpeIlwdiCxZjDoeY1idiCPRz22N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjh3Nkeg{txO	NX3rRXcxW0GQR1XS
human RH-1 cell	M3rlRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MX\Jcohq[mm2aX;uJI9nKGi3bXHuJHJJNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkewNlc1KM7:TR?=	NYDY[Zd5W0GQR1XS
human MDA-MB-157 cell	MnzaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NFXpN5ZKdmirYnn0bY9vKG:oIHj1cYFvKE2GQT3NRk0yPTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkexOlc1KM7:TR?=	NH3HbpBUSU6JRWK=
human A427 cell	NGjPdVlIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NH3FZW9KdmirYnn0bY9vKG:oIHj1cYFvKEF2MkegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc{PTh7IN88US=>	MlXqV2FPT0WU
human ES1 cell	M4DUemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NGXiWpJKdmirYnn0bY9vKG:oIHj1cYFvKEWVMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUGuO\|U1PTFizszN	NInQXHBUSU6JRWK=
human C32 cell	M2jFbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NY\mflY2UW6qaXLpeIlwdiCxZjDoeY1idiCFM{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc3OzlizszN	MkHyV2FPT0WU
human LAMA-84 cell	NE\NUldIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NUTmdII{UW6qaXLpeIlwdiCxZjDoeY1idiCOQV3BMVg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS55Nki3NkDPxE1?	M{PxcHNCVkeHUh?=
human YKG-1 cell	NIDNPWpIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MoqwTY5pcWKrdHnvckBw\iCqdX3hckB[U0dvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUGuO\|cyOjRizszN	NID5fohUSU6JRWK=
human NCI-H1048 cell	Mk[4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NGHpW2lKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVA1QCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTFwN{i1NFkh\|ryP	M2PXRXNCVkeHUh?=
human KS-1 cell	MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NXrW[4F6UW6qaXLpeIlwdiCxZjDoeY1idiCNUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45Ojl6IN88US=>	MU\TRW5ITVJ?
human JVM-3 cell	MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MX\Jcohq[mm2aX;uJI9nKGi3bXHuJGpXVS1\|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MT64OlQ6OSEQvF2=	MX3TRW5ITVJ?
human GI-ME-N cell	NUn4TGRHT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NIrCNmdKdmirYnn0bY9vKG:oIHj1cYFvKEeLLV3FMW4h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjh4NUOg{txO	NGPudFlUSU6JRWK=
human GT3TKB cell	NXHi[m84T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MX3Jcohq[mm2aX;uJI9nKGi3bXHuJGdVO1SNQjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUGuPFk3PDJizszN	M3Sxc3NCVkeHUh?=
human CHL-1 cell	NXX6W\|BzT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		Mm\TTY5pcWKrdHnvckBw\iCqdX3hckBEUExvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUGuPVI{PzlizszN	M1HtWXNCVkeHUh?=
human CHP-134 cell	M133VWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		M{HTU2lvcGmkaYTpc44hd2ZiaIXtZY4hS0iSLUGzOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTR2Nkeg{txO	NH60e3BUSU6JRWK=
human 8-MG-BA cell	NXfjZZR6T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NUOzUopTUW6qaXLpeIlwdiCxZjDoeY1idiB6LV3HMWJCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57NUe0OEDPxE1?	NFvwRVFUSU6JRWK=
human HO-1-N-1 cell	M{TMW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NW\BWnhwUW6qaXLpeIlwdiCxZjDoeY1idiCKTz2xMW4uOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTFwOUexNVch\|ryP	M{[1R3NCVkeHUh?=
human SW1088 cell	NF\D[IhIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		M3;0[WlvcGmkaYTpc44hd2ZiaIXtZY4hW1dzMEi4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46QTZ5MzFOwG0>	M4C3N3NCVkeHUh?=
human SW48 cell	NWOzXXZrT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MmLrTY5pcWKrdHnvckBw\iCqdX3hckBUXzR6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;Mj6wNlA3PyEQvF2=	MVfTRW5ITVJ?
human VM-CUB-1 cell	NVuyWlFsT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NHL0SpZKdmirYnn0bY9vKG:oIHj1cYFvKF[PLVPVRk0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5yNEGxPUDPxE1?	M4rYenNCVkeHUh?=
human COLO-800 cell	MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		M{\ycGlvcGmkaYTpc44hd2ZiaIXtZY4hS0:OTz24NFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjB3MUO2JO69VQ>?	NH;HRndUSU6JRWK=
human TI-73 cell	NY[x[YFyT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MoDVTY5pcWKrdHnvckBw\iCqdX3hckBVUS15MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUKuNVE{QTlizszN	M1nwbnNCVkeHUh?=
human HN cell	M2TwO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NV\wVmtKUW6qaXLpeIlwdiCxZjDoeY1idiCKTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUKuNVIyQThizszN	MXPTRW5ITVJ?
human DB cell	MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NUmzU3ZzUW6qaXLpeIlwdiCxZjDoeY1idiCGQjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUKuNVI3OzFizszN	Ml7iV2FPT0WU
human Ca9-22 cell	NF:4fZpIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		M{DrRmlvcGmkaYTpc44hd2ZiaIXtZY4hS2F7LUKyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yOjh2NzFOwG0>	M3[4fXNCVkeHUh?=
human A549 cell	M3vofmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MVrJcohq[mm2aX;uJI9nKGi3bXHuJGE2PDliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGzPFA5KM7:TR?=	NIj4PVBUSU6JRWK=
human KGN cell	NH\INItIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NYrXVXVMUW6qaXLpeIlwdiCxZjDoeY1idiCNR16gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlIzPTl3IN88US=>	MXLTRW5ITVJ?
human BCPAP cell	Mni2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NUS2OpJrUW6qaXLpeIlwdiCxZjDoeY1idiCEQ2DBVEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjNzNUig{txO	MVvTRW5ITVJ?
human Ramos-2G6-4C10 cell	NHjzbFhIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MoPvTY5pcWKrdHnvckBw\iCqdX3hckBT[W2xcz2yS\|YuPENzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUKuNlM4PTlizszN	M1rVS3NCVkeHUh?=
human OVCAR-5 cell	NF3Sd3NIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NVnvcZJ6UW6qaXLpeIlwdiCxZjDoeY1idiCRVlPBVk02KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5{N{ezOEDPxE1?	M4HXOnNCVkeHUh?=
human KG-1 cell	MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NF7CWpdKdmirYnn0bY9vKG:oIHj1cYFvKEuJLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI4Pzl{IN88US=>	MUjTRW5ITVJ?
human CAKI-1 cell	NVS3TnJwT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NFj2XYJKdmirYnn0bY9vKG:oIHj1cYFvKEODS1mtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjhyNUig{txO	MknIV2FPT0WU
human QIMR-WIL cell	NGDzZXFIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NF3KcVRKdmirYnn0bY9vKG:oIHj1cYFvKFGLTWKtW2lNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5{OEe0OEDPxE1?	M1:1UXNCVkeHUh?=
human SW1710 cell	NUT5dWR4T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MkTBTY5pcWKrdHnvckBw\iCqdX3hckBUXzF5MUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI6OTR{IN88US=>	NHHVZllUSU6JRWK=
human SK-UT-1 cell	NWLLNGJ2T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		M1j0OGlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvVWStNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjl\|M{mg{txO	NUXSOlh1W0GQR1XS
human IST-SL1 cell	M2rlWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		M1Hq[GlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLWPMNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzJzN{Sg{txO	MlrsV2FPT0WU
human SW962 cell	Mnj4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		MULJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTZ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;Mj6zN\|c2PyEQvF2=	MlG1V2FPT0WU
human EM-2 cell	MoK0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NHuyeItKdmirYnn0bY9vKG:oIHj1cYFvKEWPLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM2OzN5IN88US=>	M2\BO3NCVkeHUh?=
human D-263MG cell	NV\vO4xLT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NUXibJIzUW6qaXLpeIlwdiCxZjDoeY1idiCGLUK2N21IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5\|OEOyO{DPxE1?	MVnTRW5ITVJ?
human T98G cell	M4LV[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MnW1TY5pcWKrdHnvckBw\iCqdX3hckBVQTiJIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;Mj6zPFg2PyEQvF2=	M3T0OHNCVkeHUh?=
human CTB-1 cell	M13sUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NUjxV5R2UW6qaXLpeIlwdiCxZjDoeY1idiCFVFKtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzl5NkGg{txO	NXvPfY93W0GQR1XS
human Hs-578-T cell	MmW3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		M13oS2lvcGmkaYTpc44hd2ZiaIXtZY4hUHNvNUe4MXQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjRzNUi3JO69VQ>?	NXjDTG1tW0GQR1XS
human SF126 cell	NXzJNYs4T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NYLBNIdEUW6qaXLpeIlwdiCxZjDoeY1idiCVRkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPDN4MkGg{txO	M1jKbnNCVkeHUh?=
human NCI-H460 cell	Mm\aS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NXfGUVRtUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFQ3OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTJwNEO5OVUh\|ryP	MnXwV2FPT0WU
human NCI-H1755 cell	MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		M3;pR2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixO\|U2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi53NEC0N{DPxE1?	MV3TRW5ITVJ?
human HL-60 cell	NWLPZpJkT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MlLGTY5pcWKrdHnvckBw\iCqdX3hckBJVC14MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUKuOVQyPTlizszN	MmjHV2FPT0WU
human G-401 cell	M36yTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NE[weWNKdmirYnn0bY9vKG:oIHj1cYFvKEdvNECxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42PjB7OTFOwG0>	NU\JRmR1W0GQR1XS
human AGS cell	M4HIXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MkG3TY5pcWKrdHnvckBw\iCqdX3hckBCT1NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkW2NlU4KM7:TR?=	MojjV2FPT0WU
human HuO9 cell	NYHuXY01T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NWCzb2Z{UW6qaXLpeIlwdiCxZjDoeY1idiCKdV:5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42PjR3NjFOwG0>	MkDqV2FPT0WU
human MFE-280 cell	NVjIeoZqT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		M{DlNmlvcGmkaYTpc44hd2ZiaIXtZY4hVU[HLUK4NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTZ4OE[g{txO	M{XhWXNCVkeHUh?=
human NCI-H292 cell	MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MWDJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkmyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42Pzd{MjFOwG0>	MknhV2FPT0WU
human HuO-3N1 cell	M4T4Wmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MWjJcohq[mm2aX;uJI9nKGi3bXHuJGh2Vy1\|TkGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlYxOzB5IN88US=>	M4LpZ3NCVkeHUh?=
human ES3 cell	MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MkPOTY5pcWKrdHnvckBw\iCqdX3hckBGWzNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[yNlg2KM7:TR?=	M{\SV3NCVkeHUh?=
human LB2241-RCC cell	MoDQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		MVnJcohq[mm2aX;uJI9nKGi3bXHuJGxDOjJ2MT3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjZ7MEe5JO69VQ>?	MnvRV2FPT0WU
human NCI-H1155 cell	NH7qeI1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MYrJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUG1OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPjl2MEWg{txO	M{PnOHNCVkeHUh?=
human SW872 cell	M3zyT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NXvYOlBsUW6qaXLpeIlwdiCxZjDoeY1idiCVV{i3NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzB4N{[g{txO	NIfZUIdUSU6JRWK=
human MHH-ES-1 cell	NYCwfY1tT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NIXOSXNKdmirYnn0bY9vKG:oIHj1cYFvKE2KSD3FV{0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi55Mk[zN{DPxE1?	NUnEVIx{W0GQR1XS
human KYSE-150 cell	Mkn3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		M3jKNmlvcGmkaYTpc44hd2ZiaIXtZY4hU1mVRT2xOVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjd{OUeg{txO	NUXrUWlwW0GQR1XS
human MC-IXC cell	M4\4Vmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NVnGOIpjUW6qaXLpeIlwdiCxZjDoeY1idiCPQz3JXGMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjh7NUOg{txO	NYT6c2JGW0GQR1XS
human HCC1187 cell	MoPyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		M3\hbGlvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMUG4O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQDl4N{eg{txO	NEnJS\|JUSU6JRWK=
human UMC-11 cell	MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		M2jwWmlvcGmkaYTpc44hd2ZiaIXtZY4hXU2FLUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk46ODR5NzFOwG0>	MUHTRW5ITVJ?
human NB5 cell	MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MoXYTY5pcWKrdHnvckBw\iCqdX3hckBPSjViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkmzO\|E2KM7:TR?=	M3O1fnNCVkeHUh?=
human A2058 cell	NXP0eHNuT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NHfQPFJKdmirYnn0bY9vKG:oIHj1cYFvKEF{MEW4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk46Pzh2NDFOwG0>	Ml;4V2FPT0WU
human Becker cell	NYrjNZZKT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NE\zVnJKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvODFzMUKg{txO	NE\EdGFUSU6JRWK=
human CAS-1 cell	MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NIKwenRKdmirYnn0bY9vKG:oIHj1cYFvKEODUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4xOTV4OTFOwG0>	M3jke3NCVkeHUh?=
human SW780 cell	NVnHR\|AyT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		M1jmR2lvcGmkaYTpc44hd2ZiaIXtZY4hW1d5OECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI2PjB7IN88US=>	M1;ZZXNCVkeHUh?=
human KM12 cell	MnzHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		MkS2TY5pcWKrdHnvckBw\iCqdX3hckBMVTF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;Mz6zNFE{OiEQvF2=	MV;TRW5ITVJ?
human PC-3 cell	M{TMXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NVnsRlZvUW6qaXLpeIlwdiCxZjDoeY1idiCSQz2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yPzRzMTFOwG0>	MnKxV2FPT0WU
human A253 cell	M33DdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		Mnj1TY5pcWKrdHnvckBw\iCqdX3hckBCOjV\|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;ND6xPFg6OyEQvF2=	MVHTRW5ITVJ?
human NB10 cell	MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		M3vYfmlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUSuNlI4PzNizszN	M1fnSXNCVkeHUh?=
human A172 cell	NX;xcWlOT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NVTyXnJvUW6qaXLpeIlwdiCxZjDoeY1idiCDMUeyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE41PDV5IN88US=>	MVnTRW5ITVJ?
human A498 cell	MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NXHBWm5IUW6qaXLpeIlwdiCxZjDoeY1idiCDNEm4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE42PjN6MzFOwG0>	M1;QWHNCVkeHUh?=
human SW1573 cell	M{HsUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		M3XCZmlvcGmkaYTpc44hd2ZiaIXtZY4hW1dzNUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok46ODR7MTFOwG0>	MWTTRW5ITVJ?
human 5637 cell	NIXLVWVIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NUDFRXI4UW6qaXLpeIlwdiCxZjDoeY1idiB3NkO3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4xPzlyNDFOwG0>	MW\TRW5ITVJ?
human A388 cell	MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NVz3PIR3UW6qaXLpeIlwdiCxZjDoeY1idiCDM{i4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlEvOTN7ODFOwG0>	MXfTRW5ITVJ?
human U251 cell	NUSyVoU1T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MWXJcohq[mm2aX;uJI9nKGi3bXHuJHUzPTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{OD6xNVc2KM7:TR?=	NVPCVHFnW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-p38 / p38 / p-JNK / JNK / gD-2 ; PubMed: 28112176 Acta Pharmacol Sin BX-795 inhibition on HSV replication attenuated by overexpression of p38/JNK. HeLa cells with or without JNK1 or p38 overexpression were infected with HSV-2 and total cellular protein was prepared for WB analysis. gD-2, the phosphorylation level of p38 MA䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖Ѐ瑖堘 pTBK1 / TBK1 / pPLK1 / PLK1; PubMed: 26772203 Mol Cancer Ther TBK1 mediated activation of the mitotic kinase PLK1. SW210.5 cells were treated with indicated TBK1 inhibitors for 1 hour and then exposed to 50 ng/mL of nocodazole for 18 hours. Western blot detected the signaling change using indicated antibodies, and β䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ	28112176 26772203
Growth inhibition assay	Cell viability ; PubMed: 26772203 Mol Cancer Ther Four SCLC cell lines with no MYC amplification were treated with TBK1 inhibitor BX-795 at the titration concentration. Cell viability was performed by CellTiter Glo 4 days after treatment. The growth curve was constructed by GraphPad Prism 6.	26772203

激酶实验：^[1]	- 合并蛋白激酶实验: 加入[γ-³²P]ATP(1000 cpm/pmol)开始实验，终浓度为0.1 mM。使用GST-IRF3作为底物, BX795抑制反应在30^oC下进行30分钟，加入含40 mM EDTA,pH 为7.0的SDS终止反应，在100^oC下加热5分钟，通过SDS-PAGE分离, 然后通过放射自显影技术测定磷酸化的蛋白。通过感光成像分析进行量化处理。IκBα底物肽实验在30^oC下进行10分钟，使一部分反应物放到一张2×2-cm²浸泡在75 mM磷酸中的磷酸纤维素P81纸上，终止反应。在磷酸中冲洗6次，在丙酮中冲洗1次，烘干纸，计数。
细胞实验：^[3]	- 合并 Cell lines: MDA-468, MDA-453, HCT-116, U87-MG Concentrations: 0.001-1 μM Incubation Time: 72小时 Method: 细胞系包括MDA-468,MDA-453,HCT-116,U87-MG等按每孔1.5-3×10³个细胞接种在96孔板上，过夜。每孔加入溶于1% DMSO和生长培养基(DMSO最终浓度为0.1%)的10 μL BX795, 震荡处理。细胞温育72小时，加入10 μL代谢染料测定活力。在450 nm处测定WST-1信号。 (Only for Reference)

参考文献

溶解度 (25°C)

体外	DMSO	100 mg/mL (169.07 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 2% DMSO+30% PEG +2% Tween 80+ddH2O	4mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download BX-795 SDF

分子量	591.47
化学式	C₂₃H₂₆IN₇O₂S
CAS号	702675-74-9
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
Can you suggest an in vivo formulation of S1274 for animal studies?
回答：
We recommend to use the vehicle 2% DMSO+30% PEG +2% Tween 80+ddH2O for in vivo study.

研究领域

产品类型

定制您的化合物库

BX-795

客户使用Selleck生产的BX-795发表文献41篇：

产品安全说明书

PDK抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download BX-795 SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

技术支持

常见问题及建议解决方法

PDK Signaling Pathway Map

相关PDK产品