BX-795

For research use only. Not for use in humans.

目录号:S1274

BX-795 Chemical Structure

CAS No. 702675-74-9

BX-795 是一种有效的,特异性的PDK1抑制剂,在无细胞试验中IC50为6 nM,作用于PDK1比作用于PKA和PKC选择性分别高140和1600倍。同时,相比于 GSK3β,作用于PDK1的选择性高出100多倍。BX-795 可通过抑制 ULK1 来调节自噬。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1628.91 现货
RMB 1236.66 现货
RMB 2623.21 现货
RMB 4662.25 现货
RMB 7931.08 现货
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客户使用Selleck生产的BX-795发表文献41篇:

产品安全说明书

PDK抑制剂选择性比较

生物活性

产品描述 BX-795 是一种有效的,特异性的PDK1抑制剂,在无细胞试验中IC50为6 nM,作用于PDK1比作用于PKA和PKC选择性分别高140和1600倍。同时,相比于 GSK3β,作用于PDK1的选择性高出100多倍。BX-795 可通过抑制 ULK1 来调节自噬。
靶点
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
体外研究

BX795也抑制MARK1,MARK2,MARK4,NUAK1,VEGFR,MLK1,MLK2,和MLK3,IC50分别为55,53,19,5,157,50,46和42 nM。1 μM BX795不抑制如下酪氨酸蛋白激酶: 肝配蛋白受体A2和B3,Syk,Bruton's酪氨酸激酶,和FGFR1。然而,BX795抑制VEGFR,抑制效果比TBK1低。BX795抑制TBK1-催化的IRF3在Ser396位点磷酸化随着ATP浓度上升而下降,说明BX795是ATP竞争性抑制剂。BX795阻断TBK1和IKKε调节的IRF3激活,且抑制IFN-β的产量。聚(I:C)处理后,IRF3在核中积累,但是可被BX795抑制。 BX795抑制IRF3依赖的基因转录。BX795抑制IFN-β从巨噬细胞中分泌。BX795对LPS刺激的p70核糖体S6激酶1在Thr229位点磷酸化没有效果, Thr229位点是PDK1作用靶点。BX795不影响IKKα/β复合体或LPS,聚(I:C),IL-1α,或TNFα促进的NFκB依赖的基因转录的激活。BX795作用于IL-1α或TNFα刺激的MEFs,也阻断JNK1/2和p38α MAPK磷酸化。BX795抑制TBK1/IKKε不会导致JNK1/2和p38α MAPK的激活。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell Mmn1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1zCNGlvcGmkaYTpc44hd2ZiaIXtZY4hVVZvND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM3Njhibl2= NXfLXmN5W0GQR1XS
KRX cells NFvsdWtHfW6ldHnvckBie3OjeR?= MmXVO{BucW6| NYrnPYRyUW6qaXLpeIlwdiCxZjDTWW1QNXSjZ3fl[EBWVEtzIDj1cotvd3ewIH;ybYdqdilia3nuZZNmKGSxbXHpckBmgHC{ZYPz[YQhcW5iS2LYJINmdGy|IIXzbY5oKFt|MmDdMYdidW2jLVHUVEBidmRibYnlcIlvKGKjc3njJJBzd3SnaX6gd5Vje3S{YYTlJIlv[3WkYYTl[EBnd3JiNzDtbY5{ MljqNlYzPzV4OEG=
human NKM-1 cell NIDWZ4dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWHJcohq[mm2aX;uJI9nKGi3bXHuJG5MVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6zOlE6PCEQvF2= MYXTRW5ITVJ?
human P30-OHK cell MnLTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIrJWWdKdmirYnn0bY9vKG:oIHj1cYFvKFB|MD3PTGsh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTygTWM2OD1yLkS5OlUh|ryP MmTWV2FPT0WU
human YH-13 cell NYXQOJVST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGe1dnFKdmirYnn0bY9vKG:oIHj1cYFvKFmKLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE43Ojh6ODFOwG0> NXr2NZVrW0GQR1XS
human LXF-289 cell M1qycWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF72O4lKdmirYnn0bY9vKG:oIHj1cYFvKEy[Rj2yPFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS5iSVO1NF0xNjZ3NkmzJO69VQ>? MmLDV2FPT0WU
human BE-13 cell M17HSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlexTY5pcWKrdHnvckBw\iCqdX3hckBDTS1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|A1PzdizszN MUPTRW5ITVJ?
human RS4-11 cell M13LbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWWxWIloUW6qaXLpeIlwdiCxZjDoeY1idiCUU{StNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjd{NUm0JO69VQ>? MmfkV2FPT0WU
human A3-KAW cell MlKxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M33HbGlvcGmkaYTpc44hd2ZiaIXtZY4hSTNvS1HXJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44OzB3NTFOwG0> M4TzNnNCVkeHUh?=
human PA-1 cell NITHRlBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUTJcohq[mm2aX;uJI9nKGi3bXHuJHBCNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkiwOFIzKM7:TR?= NEPMVZZUSU6JRWK=
human ES7 cell M1jJZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIn6[XVKdmirYnn0bY9vKG:oIHj1cYFvKEWVNzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFM2PjZizszN MmOyV2FPT0WU
human ES8 cell NFfqS5pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYf4SlBKUW6qaXLpeIlwdiCxZjDoeY1idiCHU{igZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg1OzN4IN88US=> MmPvV2FPT0WU
human SW982 cell M4HjUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3XwbmlvcGmkaYTpc44hd2ZiaIXtZY4hW1d7OEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlk2OTJ2IN88US=> MkjHV2FPT0WU
human VA-ES-BJ cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUjJcohq[mm2aX;uJI9nKGi3bXHuJHZCNUWVLVLKJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE46QDR4NzFOwG0> NFGxSZlUSU6JRWK=
human 697 cell NGfM[olIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{fIdGlvcGmkaYTpc44hd2ZiaIXtZY4hPjl5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wNVYzOyEQvF2= M3Xa[XNCVkeHUh?=
human MOLT-4 cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnvhTY5pcWKrdHnvckBw\iCqdX3hckBOV0yWLUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA{OjR2IN88US=> MX3TRW5ITVJ?
human D-283MED cell M4OyUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUfUcHN[UW6qaXLpeIlwdiCxZjDoeY1idiCGLUK4N21GTCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMEO5OFgh|pyv MVHTRW5ITVJ?
human ALL-PO cell NUnQZY9xT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{m3eWlvcGmkaYTpc44hd2ZiaIXtZY4hSUyOLWDPJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xPjB5MzFOwG0> M{DMOnNCVkeHUh?=
human NB14 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWnJcohq[mm2aX;uJI9nKGi3bXHuJG5DOTRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkC2NFgyKM7:TR?= M2nMSHNCVkeHUh?=
human NTERA-S-cl-D1 cell NE\nTplIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWjTOWZjUW6qaXLpeIlwdiCxZjDoeY1idiCQVFXSRU1UNWOuLVSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xPzd5NTFOwG0> MXLTRW5ITVJ?
human BFTC-905 cell M{TKUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXr6SGFkUW6qaXLpeIlwdiCxZjDoeY1idiCERmTDMVkxPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMEixNFEh|ryP NXvZTo9pW0GQR1XS
human H4 cell NXXJU5JTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHvkXldKdmirYnn0bY9vKG:oIHj1cYFvKEh2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xNFIxOSEQvF2= MofyV2FPT0WU
human CHP-212 cell NVLLZXh1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFv4S21KdmirYnn0bY9vKG:oIHj1cYFvKEOKUD2yNVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjF2MEO3JO69VQ>? MnTuV2FPT0WU
human A204 cell NF7zRlNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWjkW|VmUW6qaXLpeIlwdiCxZjDoeY1idiCDMkC0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPTR4NzFOwG0> NUn2fmZ3W0GQR1XS
human NB69 cell NUC2OJlOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NE\zNYJKdmirYnn0bY9vKG:oIHj1cYFvKE6ENkmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE2QDZ3IN88US=> MnjjV2FPT0WU
human P12-ICHIKAWA cell NGnPN2lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXfJcohq[mm2aX;uJI9nKGi3bXHuJHAyOi2LQ1jJT2FYSSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMUixO|Eh|ryP MVnTRW5ITVJ?
human L-363 cell NGfGWYxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUnJcohq[mm2aX;uJI9nKGi3bXHuJGwuOzZ|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xPFE6PyEQvF2= NVjuemZIW0GQR1XS
human ES5 cell NFKy[W1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1LWN2lvcGmkaYTpc44hd2ZiaIXtZY4hTVN3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xPVM2PCEQvF2= NE\u[IlUSU6JRWK=
human CAL-51 cell NETiTJVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4P1bWlvcGmkaYTpc44hd2ZiaIXtZY4hS0GOLUWxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zOjF3NjFOwG0> Mof4V2FPT0WU
human NBsusSR cell NVOyPFFpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{LRRmlvcGmkaYTpc44hd2ZiaIXtZY4hVkK|dYPTVkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjR3N{ig{txO MUnTRW5ITVJ?
human HOP-92 cell NH3keVlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnG2TY5pcWKrdHnvckBw\iCqdX3hckBJV1BvOUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI4Ojl|IN88US=> NUjP[Fc{W0GQR1XS
human DU-4475 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYC2eopqUW6qaXLpeIlwdiCxZjDoeY1idiCGVT20OFc2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5{OUK0OUDPxE1? NGf1Z|lUSU6JRWK=
human LB1047-RCC cell NVThVoNKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1PJRWlvcGmkaYTpc44hd2ZiaIXtZY4hVEJzMES3MXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMkmyPFEh|ryP M4m5e3NCVkeHUh?=
human D-566MG cell M2exRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFPhcpBKdmirYnn0bY9vKG:oIHj1cYFvKERvNU[2UWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjNyNES4JO69VQ>? MofaV2FPT0WU
human A375 cell NWfldnB3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWHqfo53UW6qaXLpeIlwdiCxZjDoeY1idiCDM{e1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{ODh3ODFOwG0> M3y4PXNCVkeHUh?=
human ATN-1 cell NFjI[YZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHvVUW9KdmirYnn0bY9vKG:oIHj1cYFvKEGWTj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{PzF6NTFOwG0> MUHTRW5ITVJ?
human M059J cell NUL1NJoyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVPJcohq[mm2aX;uJI9nKGi3bXHuJG0xPTmMIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zO|Y2OiEQvF2= Mk\VV2FPT0WU
human HSC-3 cell NYfQWXp[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHT2N3RKdmirYnn0bY9vKG:oIHj1cYFvKEiVQz2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41PDJyODFOwG0> NUPkdXRWW0GQR1XS
human DOHH-2 cell NHzxWGNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkfaTY5pcWKrdHnvckBw\iCqdX3hckBFV0iKLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ2QDF2IN88US=> MXLTRW5ITVJ?
human G-402 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3jvN2lvcGmkaYTpc44hd2ZiaIXtZY4hTy12MEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ3PTJ3IN88US=> NYXXdJBpW0GQR1XS
human LC-2-ad cell NHjR[ZdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWDvbFI5UW6qaXLpeIlwdiCxZjDoeY1idiCOQz2yMYFlKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS52N{GzNkDPxE1? NWL0NohDW0GQR1XS
human LOXIMVI cell MmfoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEj6XJJKdmirYnn0bY9vKG:oIHj1cYFvKEyRWFnNWmkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjVyNUWyJO69VQ>? M4XxT3NCVkeHUh?=
human DK-MG cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnvGTY5pcWKrdHnvckBw\iCqdX3hckBFUy2PRzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOVczQThizszN MX3TRW5ITVJ?
human HOS cell NFrScnFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NV31cIF{UW6qaXLpeIlwdiCxZjDoeY1idiCKT2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU4OzB7IN88US=> M1m0eHNCVkeHUh?=
human BHT-101 cell NV;z[lhbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVnCUpRbUW6qaXLpeIlwdiCxZjDoeY1idiCESGStNVAyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS53N{i3O{DPxE1? MWXTRW5ITVJ?
human U-2-OS cell NGfjPWhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{TYS2lvcGmkaYTpc44hd2ZiaIXtZY4hXS1{LV;TJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42QDhyNjFOwG0> NE\0W2VUSU6JRWK=
human D-423MG cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXLSZmdbUW6qaXLpeIlwdiCxZjDoeY1idiCGLUSyN21IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS54MEiwOkDPxE1? MXPTRW5ITVJ?
human AN3-CA cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVniZ4F4UW6qaXLpeIlwdiCxZjDoeY1idiCDTkOtR2Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjZ|OUmxJO69VQ>? MknCV2FPT0WU
human TE-11 cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mkf5TY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlUzQCEQvF2= MUTTRW5ITVJ?
human SK-NEP-1 cell NVjqR5VJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWrKWnF[UW6qaXLpeIlwdiCxZjDoeY1idiCVSz3OSXAuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwNkWzO|Yh|ryP NHHhdmtUSU6JRWK=
human MG-63 cell MknBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXfmeFU4UW6qaXLpeIlwdiCxZjDoeY1idiCPRz22N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjh3Nkeg{txO NX3rRXcxW0GQR1XS
human RH-1 cell M3rlRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX\Jcohq[mm2aX;uJI9nKGi3bXHuJHJJNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkewNlc1KM7:TR?= NYDY[Zd5W0GQR1XS
human MDA-MB-157 cell MnzaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFXpN5ZKdmirYnn0bY9vKG:oIHj1cYFvKE2GQT3NRk0yPTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkexOlc1KM7:TR?= NH3HbpBUSU6JRWK=
human A427 cell NGjPdVlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH3FZW9KdmirYnn0bY9vKG:oIHj1cYFvKEF2MkegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc{PTh7IN88US=> MlXqV2FPT0WU
human ES1 cell M4DUemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGXiWpJKdmirYnn0bY9vKG:oIHj1cYFvKEWVMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|U1PTFizszN NInQXHBUSU6JRWK=
human C32 cell M2jFbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NY\mflY2UW6qaXLpeIlwdiCxZjDoeY1idiCFM{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc3OzlizszN MkHyV2FPT0WU
human LAMA-84 cell NE\NUldIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUTmdII{UW6qaXLpeIlwdiCxZjDoeY1idiCOQV3BMVg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS55Nki3NkDPxE1? M{PxcHNCVkeHUh?=
human YKG-1 cell NIDNPWpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoqwTY5pcWKrdHnvckBw\iCqdX3hckB[U0dvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|cyOjRizszN NID5fohUSU6JRWK=
human NCI-H1048 cell Mk[4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGHpW2lKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVA1QCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{i1NFkh|ryP M2PXRXNCVkeHUh?=
human KS-1 cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXrW[4F6UW6qaXLpeIlwdiCxZjDoeY1idiCNUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45Ojl6IN88US=> MU\TRW5ITVJ?
human JVM-3 cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX\Jcohq[mm2aX;uJI9nKGi3bXHuJGpXVS1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT64OlQ6OSEQvF2= MX3TRW5ITVJ?
human GI-ME-N cell NUn4TGRHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIrCNmdKdmirYnn0bY9vKG:oIHj1cYFvKEeLLV3FMW4h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjh4NUOg{txO NGPudFlUSU6JRWK=
human GT3TKB cell NXHi[m84T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX3Jcohq[mm2aX;uJI9nKGi3bXHuJGdVO1SNQjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPFk3PDJizszN M3Sxc3NCVkeHUh?=
human CHL-1 cell NXX6W|BzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mm\TTY5pcWKrdHnvckBw\iCqdX3hckBEUExvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPVI{PzlizszN M1HtWXNCVkeHUh?=
human CHP-134 cell M133VWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{HTU2lvcGmkaYTpc44hd2ZiaIXtZY4hS0iSLUGzOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTR2Nkeg{txO NH60e3BUSU6JRWK=
human 8-MG-BA cell NXfjZZR6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUOzUopTUW6qaXLpeIlwdiCxZjDoeY1idiB6LV3HMWJCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57NUe0OEDPxE1? NFvwRVFUSU6JRWK=
human HO-1-N-1 cell M{TMW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NW\BWnhwUW6qaXLpeIlwdiCxZjDoeY1idiCKTz2xMW4uOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwOUexNVch|ryP M{[1R3NCVkeHUh?=
human SW1088 cell NF\D[IhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3;0[WlvcGmkaYTpc44hd2ZiaIXtZY4hW1dzMEi4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46QTZ5MzFOwG0> M4C3N3NCVkeHUh?=
human SW48 cell NWOzXXZrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmLrTY5pcWKrdHnvckBw\iCqdX3hckBUXzR6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6wNlA3PyEQvF2= MVfTRW5ITVJ?
human VM-CUB-1 cell NVuyWlFsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHL0SpZKdmirYnn0bY9vKG:oIHj1cYFvKF[PLVPVRk0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5yNEGxPUDPxE1? M4rYenNCVkeHUh?=
human COLO-800 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{\ycGlvcGmkaYTpc44hd2ZiaIXtZY4hS0:OTz24NFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjB3MUO2JO69VQ>? NH;HRndUSU6JRWK=
human TI-73 cell NY[x[YFyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoDVTY5pcWKrdHnvckBw\iCqdX3hckBVUS15MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVE{QTlizszN M1nwbnNCVkeHUh?=
human HN cell M2TwO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV\wVmtKUW6qaXLpeIlwdiCxZjDoeY1idiCKTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVIyQThizszN MXPTRW5ITVJ?
human DB cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUmzU3ZzUW6qaXLpeIlwdiCxZjDoeY1idiCGQjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVI3OzFizszN Ml7iV2FPT0WU
human Ca9-22 cell NF:4fZpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{DrRmlvcGmkaYTpc44hd2ZiaIXtZY4hS2F7LUKyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yOjh2NzFOwG0> M3[4fXNCVkeHUh?=
human A549 cell M3vofmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVrJcohq[mm2aX;uJI9nKGi3bXHuJGE2PDliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGzPFA5KM7:TR?= NIj4PVBUSU6JRWK=
human KGN cell NH\INItIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYrXVXVMUW6qaXLpeIlwdiCxZjDoeY1idiCNR16gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlIzPTl3IN88US=> MXLTRW5ITVJ?
human BCPAP cell Mni2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUS2OpJrUW6qaXLpeIlwdiCxZjDoeY1idiCEQ2DBVEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjNzNUig{txO MVvTRW5ITVJ?
human Ramos-2G6-4C10 cell NHjzbFhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoPvTY5pcWKrdHnvckBw\iCqdX3hckBT[W2xcz2yS|YuPENzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlM4PTlizszN M1rVS3NCVkeHUh?=
human OVCAR-5 cell NF3Sd3NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVnvcZJ6UW6qaXLpeIlwdiCxZjDoeY1idiCRVlPBVk02KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5{N{ezOEDPxE1? M4HXOnNCVkeHUh?=
human KG-1 cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF7CWpdKdmirYnn0bY9vKG:oIHj1cYFvKEuJLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI4Pzl{IN88US=> MUjTRW5ITVJ?
human CAKI-1 cell NVS3TnJwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFj2XYJKdmirYnn0bY9vKG:oIHj1cYFvKEODS1mtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjhyNUig{txO MknIV2FPT0WU
human QIMR-WIL cell NGDzZXFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF3KcVRKdmirYnn0bY9vKG:oIHj1cYFvKFGLTWKtW2lNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5{OEe0OEDPxE1? M1:1UXNCVkeHUh?=
human SW1710 cell NUT5dWR4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkTBTY5pcWKrdHnvckBw\iCqdX3hckBUXzF5MUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI6OTR{IN88US=> NHHVZllUSU6JRWK=
human SK-UT-1 cell NWLLNGJ2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1j0OGlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvVWStNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjl|M{mg{txO NUXSOlh1W0GQR1XS
human IST-SL1 cell M2rlWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1Hq[GlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLWPMNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzJzN{Sg{txO MlrsV2FPT0WU
human SW962 cell Mnj4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MULJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTZ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zN|c2PyEQvF2= MlG1V2FPT0WU
human EM-2 cell MoK0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHuyeItKdmirYnn0bY9vKG:oIHj1cYFvKEWPLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM2OzN5IN88US=> M2\BO3NCVkeHUh?=
human D-263MG cell NV\vO4xLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUXibJIzUW6qaXLpeIlwdiCxZjDoeY1idiCGLUK2N21IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5|OEOyO{DPxE1? MVnTRW5ITVJ?
human T98G cell M4LV[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnW1TY5pcWKrdHnvckBw\iCqdX3hckBVQTiJIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zPFg2PyEQvF2= M3T0OHNCVkeHUh?=
human CTB-1 cell M13sUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUjxV5R2UW6qaXLpeIlwdiCxZjDoeY1idiCFVFKtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzl5NkGg{txO NXvPfY93W0GQR1XS
human Hs-578-T cell MmW3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M13oS2lvcGmkaYTpc44hd2ZiaIXtZY4hUHNvNUe4MXQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjRzNUi3JO69VQ>? NXjDTG1tW0GQR1XS
human SF126 cell NXzJNYs4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYLBNIdEUW6qaXLpeIlwdiCxZjDoeY1idiCVRkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPDN4MkGg{txO M1jKbnNCVkeHUh?=
human NCI-H460 cell Mm\aS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXfGUVRtUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFQ3OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNEO5OVUh|ryP MnXwV2FPT0WU
human NCI-H1755 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3;pR2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixO|U2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi53NEC0N{DPxE1? MV3TRW5ITVJ?
human HL-60 cell NWLPZpJkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlLGTY5pcWKrdHnvckBw\iCqdX3hckBJVC14MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOVQyPTlizszN MmjHV2FPT0WU
human G-401 cell M36yTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NE[weWNKdmirYnn0bY9vKG:oIHj1cYFvKEdvNECxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42PjB7OTFOwG0> NU\JRmR1W0GQR1XS
human AGS cell M4HIXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkG3TY5pcWKrdHnvckBw\iCqdX3hckBCT1NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkW2NlU4KM7:TR?= MojjV2FPT0WU
human HuO9 cell NYHuXY01T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWCzb2Z{UW6qaXLpeIlwdiCxZjDoeY1idiCKdV:5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42PjR3NjFOwG0> MkDqV2FPT0WU
human MFE-280 cell NVjIeoZqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{DlNmlvcGmkaYTpc44hd2ZiaIXtZY4hVU[HLUK4NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTZ4OE[g{txO M{XhWXNCVkeHUh?=
human NCI-H292 cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWDJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkmyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42Pzd{MjFOwG0> MknhV2FPT0WU
human HuO-3N1 cell M4T4Wmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWjJcohq[mm2aX;uJI9nKGi3bXHuJGh2Vy1|TkGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlYxOzB5IN88US=> M4LpZ3NCVkeHUh?=
human ES3 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkPOTY5pcWKrdHnvckBw\iCqdX3hckBGWzNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[yNlg2KM7:TR?= M{\SV3NCVkeHUh?=
human LB2241-RCC cell MoDQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVnJcohq[mm2aX;uJI9nKGi3bXHuJGxDOjJ2MT3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjZ7MEe5JO69VQ>? MnvRV2FPT0WU
human NCI-H1155 cell NH7qeI1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYrJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUG1OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPjl2MEWg{txO M{PnOHNCVkeHUh?=
human SW872 cell M3zyT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXvYOlBsUW6qaXLpeIlwdiCxZjDoeY1idiCVV{i3NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzB4N{[g{txO NIfZUIdUSU6JRWK=
human MHH-ES-1 cell NYCwfY1tT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIXOSXNKdmirYnn0bY9vKG:oIHj1cYFvKE2KSD3FV{0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi55Mk[zN{DPxE1? NUnEVIx{W0GQR1XS
human KYSE-150 cell Mkn3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3jKNmlvcGmkaYTpc44hd2ZiaIXtZY4hU1mVRT2xOVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjd{OUeg{txO NUXrUWlwW0GQR1XS
human MC-IXC cell M4\4Vmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVnGOIpjUW6qaXLpeIlwdiCxZjDoeY1idiCPQz3JXGMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjh7NUOg{txO NYT6c2JGW0GQR1XS
human HCC1187 cell MoPyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3\hbGlvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMUG4O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQDl4N{eg{txO NEnJS|JUSU6JRWK=
human UMC-11 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2jwWmlvcGmkaYTpc44hd2ZiaIXtZY4hXU2FLUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk46ODR5NzFOwG0> MUHTRW5ITVJ?
human NB5 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoXYTY5pcWKrdHnvckBw\iCqdX3hckBPSjViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkmzO|E2KM7:TR?= M3O1fnNCVkeHUh?=
human A2058 cell NXP0eHNuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHfQPFJKdmirYnn0bY9vKG:oIHj1cYFvKEF{MEW4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk46Pzh2NDFOwG0> Ml;4V2FPT0WU
human Becker cell NYrjNZZKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NE\zVnJKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvODFzMUKg{txO NE\EdGFUSU6JRWK=
human CAS-1 cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIKwenRKdmirYnn0bY9vKG:oIHj1cYFvKEODUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4xOTV4OTFOwG0> M3jke3NCVkeHUh?=
human SW780 cell NVnHR|AyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1jmR2lvcGmkaYTpc44hd2ZiaIXtZY4hW1d5OECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI2PjB7IN88US=> M1;ZZXNCVkeHUh?=
human KM12 cell MnzHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkS2TY5pcWKrdHnvckBw\iCqdX3hckBMVTF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6zNFE{OiEQvF2= MV;TRW5ITVJ?
human PC-3 cell M{TMXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVnsRlZvUW6qaXLpeIlwdiCxZjDoeY1idiCSQz2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yPzRzMTFOwG0> MnKxV2FPT0WU
human A253 cell M33DdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mnj1TY5pcWKrdHnvckBw\iCqdX3hckBCOjV|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6xPFg6OyEQvF2= MVHTRW5ITVJ?
human NB10 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3vYfmlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNlI4PzNizszN M1fnSXNCVkeHUh?=
human A172 cell NX;xcWlOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVTyXnJvUW6qaXLpeIlwdiCxZjDoeY1idiCDMUeyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE41PDV5IN88US=> MVnTRW5ITVJ?
human A498 cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXHBWm5IUW6qaXLpeIlwdiCxZjDoeY1idiCDNEm4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE42PjN6MzFOwG0> M1;QWHNCVkeHUh?=
human SW1573 cell M{HsUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3XCZmlvcGmkaYTpc44hd2ZiaIXtZY4hW1dzNUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok46ODR7MTFOwG0> MWTTRW5ITVJ?
human 5637 cell NIXLVWVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUDFRXI4UW6qaXLpeIlwdiCxZjDoeY1idiB3NkO3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4xPzlyNDFOwG0> MW\TRW5ITVJ?
human A388 cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVz3PIR3UW6qaXLpeIlwdiCxZjDoeY1idiCDM{i4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlEvOTN7ODFOwG0> MXfTRW5ITVJ?
human U251 cell NUSyVoU1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWXJcohq[mm2aX;uJI9nKGi3bXHuJHUzPTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{OD6xNVc2KM7:TR?= NVPCVHFnW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-p38 / p38 / p-JNK / JNK / gD-2 ; 

PubMed: 28112176     


BX-795 inhibition on HSV replication attenuated by overexpression of p38/JNK. HeLa cells with or without JNK1 or p38 overexpression were infected with HSV-2 and total cellular protein was prepared for WB analysis. gD-2, the phosphorylation level of p38 MA䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖Ѐ瑖堘

pTBK1 / TBK1 / pPLK1 / PLK1; 

PubMed: 26772203     


TBK1 mediated activation of the mitotic kinase PLK1. SW210.5 cells were treated with indicated TBK1 inhibitors for 1 hour and then exposed to 50 ng/mL of nocodazole for 18 hours. Western blot detected the signaling change using indicated antibodies, and β䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ

28112176 26772203
Growth inhibition assay
Cell viability ; 

PubMed: 26772203     


Four SCLC cell lines with no MYC amplification were treated with TBK1 inhibitor BX-795 at the titration concentration. Cell viability was performed by CellTiter Glo 4 days after treatment. The growth curve was constructed by GraphPad Prism 6. 

26772203

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
- 合并

蛋白激酶实验:

加入[γ-32P]ATP(1000 cpm/pmol)开始实验,终浓度为0.1 mM。使用GST-IRF3作为底物, BX795抑制反应在30oC下进行30分钟,加入含40 mM EDTA,pH 为7.0的SDS终止反应,在100oC下加热5分钟,通过SDS-PAGE分离, 然后通过放射自显影技术测定磷酸化的蛋白。通过感光成像分析进行量化处理。IκBα底物肽实验在30oC下进行10分钟, 使一部分反应物放到一张2×2-cm2浸泡在75 mM磷酸中的磷酸纤维素P81纸上,终止反应。在磷酸中冲洗6次,在丙酮中冲洗1次,烘干纸,计数。
细胞实验:[3]
- 合并
  • Cell lines: MDA-468, MDA-453, HCT-116, U87-MG
  • Concentrations: 0.001-1 μM
  • Incubation Time: 72小时
  • Method: 细胞系包括MDA-468,MDA-453,HCT-116,U87-MG等按每孔1.5-3×103个细胞接种在96孔板上,过夜。每孔加入溶于1% DMSO和生长培养基(DMSO最终浓度为0.1%)的10 μL BX795, 震荡处理。细胞温育72小时,加入10 μL代谢染料测定活力。在450 nm处测定WST-1信号。
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (169.07 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG +2% Tween 80+ddH2O
4mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 591.47
化学式

C23H26IN7O2S

CAS号 702675-74-9
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    Can you suggest an in vivo formulation of S1274 for animal studies?

  • 回答:

    We recommend to use the vehicle 2% DMSO+30% PEG +2% Tween 80+ddH2O for in vivo study.

PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID