Serotonin Transporter

抑制剂选择性比较

Serotonin Transporter产品

目录号 产品描述 文献引用 实验数据
S1627

Nitazoxanide

Nitazoxanide (NTZ, NSC 697855)是一种人工合成的nitrothiazolyl-salicylamide衍生物,是一种抗原虫剂(作用于犬流感病毒,IC50为0.17 到0.21 μM)。Nitazoxanide 可调节自噬并抑制 mTORC1 信号传递。

S1441

Venlafaxine HCl

Venlafaxine HCl是一种5-羟色胺-去甲肾上腺素再摄取抑制剂(SNRI),用于治疗重度抑郁症,泛焦虑症,急性焦虑症以及社交恐惧症。

S3005

Paroxetine HCl

Paroxetine HCl (BRL-29060A, FG-7051)是SSRI类抗抑郁药。

S1869

Dapoxetine HCl

Dapoxetine HCl (LY-210448)是一种短效的,新型选择性5-羟色胺再摄取抑制剂。

S8021

Vortioxetine (Lu AA21004) HBr

Vortioxetine (Lu AA21004) 是一种多功能模式的羟色胺的药剂,它是 h5-HT3A receptorh5-HT7 receptor 的拮抗剂,对应的Ki值分别为3.7 nM和19 nM。Vortioxetine (Lu AA21004)也是 h5-HT1B receptor 的部分激动剂、 h5-HT1A receptor 的激动剂和 human 5-HT transporter (SERT) 的抑制剂,对应的Ki值分别为33 nM、15 nM和1.6 nM。

S1336

Fluvoxamine maleate

Fluvoxamine maleate (MK-264)是一种选择性5-羟色胺再摄取抑制剂(SSRI)。

S4053

Sertraline HCl

Sertraline HCl (CP-51974-1) 是一种5-HT抑制剂, Ki值为13 nM.

S2541

Clomipramine HCl

Clomipramine HCl 是Clomipramine的盐酸盐,抑制5-羟色胺转运蛋白(SERT),去甲肾上腺素转运体(NET)和多巴胺转运蛋白(DAT),Ki分别为0.14, 54和3 nM。

S4113

Desvenlafaxine

Desvenlafaxine (WY 45233 Succinate)是一种5-羟色胺(5-HT)去甲肾上腺素(NE)重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM。

S4064

Escitalopram Oxalate

Escitalopram Oxalate是一种选择性的5-羟色胺(5-HT)重吸收抑制剂(SSRI),Ki值为0.89 nM.

S2084

Duloxetine HCl

Duloxetine HCl (LY-248686)是一种5-羟色胺-去甲肾上腺素再摄取抑制剂,Ki为4.6 nM,用于治疗重度抑郁症和广泛性焦虑症(GAD)。

S4259

Vilazodone HCl

Vilazodone是一个组合的五羟色胺再摄取特定抑制剂(SSRI)和5-HT1A受体的部分激动剂,目前正在临床评估抑郁症的治疗。

S3140

Milnacipran HCl

Milnacipran HCl能抑制去甲肾上腺素转运蛋白(NET)和五羟色胺转运蛋白(SERT),其IC50分别是77 nM和420 Nm

S3183

Amitriptyline HCl

Amitriptyline HCl 是一种 serotonin transporter (SERT)norepinephrine transporter (NET) 的抑制剂,其Ki值分别为3.45 nM和13.3 nM。Amitriptyline HCl 还可抑制histamine receptor H1histamine receptor H45-HT2sigma 1 receptor,对应的Ki值分别是0.5 nM、7.31 nM、235 nM和287 nM。Amitriptyline 是一种三环抗抑郁药物。

S5239

Paroxetine mesylate

Paroxetine Mesylate is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.

S5947

Amitriptyline

Amitriptyline (MK-230, N-750, Ro41575) 是一种三环抗抑郁药,具有止痛效果,被广泛用于治疗抑郁和神经性疼痛。Amitriptyline 是一种 serotonin transporter (SERT)norepinephrine transporter (NET) 的抑制剂,其Ki值分别为3.45 nM和13.3 nM。Amitriptyline 还可抑制histamine receptor H1histamine receptor H45-HT2sigma 1 receptor,对应的Ki值分别是0.5 nM、7.31 nM、235 nM和287 nM。该产品呈胶状。

S5693

Levomilnacipran Hydrochloride

Levomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor with antidepressant activity.

S2282

Cinchonidine

Cinchonidine是一种生物碱,在有机化学中用于不对称合成。

S4749

Citalopram HBr

Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr)是一种抗抑郁剂,是一种常用于口服途径的选择性serotonin reuptake抑制剂,IC50为1.8 nM。

S5655

Venlafaxine

Venlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.

S5485

Desipramine Hydrochloride

Desipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects.

S4112

Desvenlafaxine Succinate

Desvenlafaxine Succinate (WY 45233) 是一种新型5-羟色胺(5-HT)转运蛋白 和去甲肾上腺素(NE)转运蛋白重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM

S5071

Duloxetine

Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake.

S5506

Vortioxetine

Vortioxetine, a novel antidepressant for the treatment of major depressive disorder, is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and serotonin (5-HT) transporter (SERT) inhibitor.

S4377

Imipramine HCl

Imipramine (Melipramine) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).

S5858

Vilazodone

Vilazodone (EMD-68843, SB-659746A)是一种新型抗抑郁剂,具有选择性5-HT再摄取抑制作用和部分5-HT1A受体激动活性。Vilazodone与5-HT重吸收位点的结合亲和力比与去甲肾上腺素和多巴胺位点结合亲和力高。

目录号 产品描述 文献引用 实验数据
S1627

Nitazoxanide

Nitazoxanide (NTZ, NSC 697855)是一种人工合成的nitrothiazolyl-salicylamide衍生物,是一种抗原虫剂(作用于犬流感病毒,IC50为0.17 到0.21 μM)。Nitazoxanide 可调节自噬并抑制 mTORC1 信号传递。

S1441

Venlafaxine HCl

Venlafaxine HCl是一种5-羟色胺-去甲肾上腺素再摄取抑制剂(SNRI),用于治疗重度抑郁症,泛焦虑症,急性焦虑症以及社交恐惧症。

S3005

Paroxetine HCl

Paroxetine HCl (BRL-29060A, FG-7051)是SSRI类抗抑郁药。

S1869

Dapoxetine HCl

Dapoxetine HCl (LY-210448)是一种短效的,新型选择性5-羟色胺再摄取抑制剂。

S8021

Vortioxetine (Lu AA21004) HBr

Vortioxetine (Lu AA21004) 是一种多功能模式的羟色胺的药剂,它是 h5-HT3A receptorh5-HT7 receptor 的拮抗剂,对应的Ki值分别为3.7 nM和19 nM。Vortioxetine (Lu AA21004)也是 h5-HT1B receptor 的部分激动剂、 h5-HT1A receptor 的激动剂和 human 5-HT transporter (SERT) 的抑制剂,对应的Ki值分别为33 nM、15 nM和1.6 nM。

S1336

Fluvoxamine maleate

Fluvoxamine maleate (MK-264)是一种选择性5-羟色胺再摄取抑制剂(SSRI)。

S4053

Sertraline HCl

Sertraline HCl (CP-51974-1) 是一种5-HT抑制剂, Ki值为13 nM.

S2541

Clomipramine HCl

Clomipramine HCl 是Clomipramine的盐酸盐,抑制5-羟色胺转运蛋白(SERT),去甲肾上腺素转运体(NET)和多巴胺转运蛋白(DAT),Ki分别为0.14, 54和3 nM。

S4113

Desvenlafaxine

Desvenlafaxine (WY 45233 Succinate)是一种5-羟色胺(5-HT)去甲肾上腺素(NE)重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM。

S4064

Escitalopram Oxalate

Escitalopram Oxalate是一种选择性的5-羟色胺(5-HT)重吸收抑制剂(SSRI),Ki值为0.89 nM.

S2084

Duloxetine HCl

Duloxetine HCl (LY-248686)是一种5-羟色胺-去甲肾上腺素再摄取抑制剂,Ki为4.6 nM,用于治疗重度抑郁症和广泛性焦虑症(GAD)。

S4259

Vilazodone HCl

Vilazodone是一个组合的五羟色胺再摄取特定抑制剂(SSRI)和5-HT1A受体的部分激动剂,目前正在临床评估抑郁症的治疗。

S3140

Milnacipran HCl

Milnacipran HCl能抑制去甲肾上腺素转运蛋白(NET)和五羟色胺转运蛋白(SERT),其IC50分别是77 nM和420 Nm

S3183

Amitriptyline HCl

Amitriptyline HCl 是一种 serotonin transporter (SERT)norepinephrine transporter (NET) 的抑制剂,其Ki值分别为3.45 nM和13.3 nM。Amitriptyline HCl 还可抑制histamine receptor H1histamine receptor H45-HT2sigma 1 receptor,对应的Ki值分别是0.5 nM、7.31 nM、235 nM和287 nM。Amitriptyline 是一种三环抗抑郁药物。

S5239

Paroxetine mesylate

Paroxetine Mesylate is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.

S5947

Amitriptyline

Amitriptyline (MK-230, N-750, Ro41575) 是一种三环抗抑郁药,具有止痛效果,被广泛用于治疗抑郁和神经性疼痛。Amitriptyline 是一种 serotonin transporter (SERT)norepinephrine transporter (NET) 的抑制剂,其Ki值分别为3.45 nM和13.3 nM。Amitriptyline 还可抑制histamine receptor H1histamine receptor H45-HT2sigma 1 receptor,对应的Ki值分别是0.5 nM、7.31 nM、235 nM和287 nM。该产品呈胶状。

S5693

Levomilnacipran Hydrochloride

Levomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor with antidepressant activity.

S2282

Cinchonidine

Cinchonidine是一种生物碱,在有机化学中用于不对称合成。

S4749

Citalopram HBr

Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr)是一种抗抑郁剂,是一种常用于口服途径的选择性serotonin reuptake抑制剂,IC50为1.8 nM。

S5655

Venlafaxine

Venlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.

S5485

Desipramine Hydrochloride

Desipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects.

S4112

Desvenlafaxine Succinate

Desvenlafaxine Succinate (WY 45233) 是一种新型5-羟色胺(5-HT)转运蛋白 和去甲肾上腺素(NE)转运蛋白重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM

S5071

Duloxetine

Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake.

S5506

Vortioxetine

Vortioxetine, a novel antidepressant for the treatment of major depressive disorder, is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and serotonin (5-HT) transporter (SERT) inhibitor.

S4377

Imipramine HCl

Imipramine (Melipramine) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).

S5858

Vilazodone

Vilazodone (EMD-68843, SB-659746A)是一种新型抗抑郁剂,具有选择性5-HT再摄取抑制作用和部分5-HT1A受体激动活性。Vilazodone与5-HT重吸收位点的结合亲和力比与去甲肾上腺素和多巴胺位点结合亲和力高。