Serotonin Transporter
抑制剂选择性比较
Serotonin Transporter产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1627 |
Nitazoxanide (NSC 697855)Nitazoxanide (NSC 697855, NTZ)是一种人工合成的nitrothiazolyl-salicylamide衍生物,是一种抗原虫剂(作用于犬流感病毒,IC50为0.17 到0.21 μM)。Nitazoxanide 可调节自噬并抑制 mTORC1 信号传递。 |
||
S1441 |
Venlafaxine HClVenlafaxine HCl是一种5-羟色胺-去甲肾上腺素再摄取抑制剂(SNRI),用于治疗重度抑郁症,泛焦虑症,急性焦虑症以及社交恐惧症。 |
||
S3005 |
Paroxetine HClParoxetine HCl (BRL-29060A, FG-7051)是SSRI类抗抑郁药。 |
||
S1869 |
Dapoxetine HClDapoxetine HCl (LY-210448)是一种短效的,新型选择性5-羟色胺再摄取抑制剂。 |
||
S8021 |
Vortioxetine (Lu AA21004) HBrVortioxetine (Lu AA21004) 是一种多功能模式的羟色胺的药剂,它是 h5-HT3A receptor 和 h5-HT7 receptor 的拮抗剂,对应的Ki值分别为3.7 nM和19 nM。Vortioxetine (Lu AA21004)也是 h5-HT1B receptor 的部分激动剂、 h5-HT1A receptor 的激动剂和 human 5-HT transporter (SERT) 的抑制剂,对应的Ki值分别为33 nM、15 nM和1.6 nM。 |
||
S1336 |
Fluvoxamine (DU-23000) maleateFluvoxamine maleate (DU-23000, MK-264)是一种选择性5-羟色胺再摄取抑制剂(SSRI)。 |
||
S4053 |
Sertraline HClSertraline HCl (CP-51974-1) 是一种5-HT抑制剂, Ki值为13 nM. |
||
S2541 |
Clomipramine HClClomipramine HCl 是Clomipramine的盐酸盐,抑制5-羟色胺转运蛋白(SERT),去甲肾上腺素转运体(NET)和多巴胺转运蛋白(DAT),Ki分别为0.14, 54和3 nM。 |
||
S4113 |
DesvenlafaxineDesvenlafaxine (WY 45233 Succinate)是一种5-羟色胺(5-HT)和去甲肾上腺素(NE)重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM。 |
||
S4064 |
Escitalopram OxalateEscitalopram Oxalate是一种选择性的5-羟色胺(5-HT)重吸收抑制剂(SSRI),Ki值为0.89 nM. |
||
S2084 |
Duloxetine HClDuloxetine HCl (LY-248686)是一种5-羟色胺-去甲肾上腺素再摄取抑制剂,Ki为4.6 nM,用于治疗重度抑郁症和广泛性焦虑症(GAD)。 |
![]() ![]() Summarized results of dose-dependent effect of duloxetine on the following: (1) the capacity of the AA-irritated bladder and (2) PNS-induced increase in bladder capacity. |
|
S4259 |
Vilazodone HClVilazodone是一个组合的五羟色胺再摄取特定抑制剂(SSRI)和5-HT1A受体的部分激动剂,目前正在临床评估抑郁症的治疗。 |
||
S3140 |
Milnacipran HClMilnacipran HCl能抑制去甲肾上腺素转运蛋白(NET)和五羟色胺转运蛋白(SERT),其IC50分别是77 nM和420 Nm |
||
S3183 |
Amitriptyline HClAmitriptyline HCl 是一种 serotonin transporter (SERT) 和 norepinephrine transporter (NET) 的抑制剂,其Ki值分别为3.45 nM和13.3 nM。Amitriptyline HCl 还可抑制histamine receptor H1、histamine receptor H4、5-HT2 和 sigma 1 receptor,对应的Ki值分别是0.5 nM、7.31 nM、235 nM和287 nM。Amitriptyline 是一种三环抗抑郁药物。 |
||
S5239 |
Paroxetine mesylateParoxetine Mesylate is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. |
||
S5947 |
AmitriptylineAmitriptyline (MK-230, N-750, Ro41575) 是一种三环抗抑郁药,具有止痛效果,被广泛用于治疗抑郁和神经性疼痛。Amitriptyline 是一种 serotonin transporter (SERT) 和 norepinephrine transporter (NET) 的抑制剂,其Ki值分别为3.45 nM和13.3 nM。Amitriptyline 还可抑制histamine receptor H1、histamine receptor H4、5-HT2 和 sigma 1 receptor,对应的Ki值分别是0.5 nM、7.31 nM、235 nM和287 nM。该产品呈胶状。 |
||
S5693 |
Levomilnacipran HydrochlorideLevomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor with antidepressant activity. |
||
S2282 |
CinchonidineCinchonidine是一种生物碱,在有机化学中用于不对称合成。 |
||
S4749 |
Citalopram HBrCitalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr)是一种抗抑郁剂,是一种常用于口服途径的选择性serotonin reuptake抑制剂,IC50为1.8 nM。 |
||
S5655 |
VenlafaxineVenlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia. |
||
S5485 |
Desipramine HydrochlorideDesipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects. |
||
S4112 |
Desvenlafaxine SuccinateDesvenlafaxine Succinate (WY 45233) 是一种新型5-羟色胺(5-HT)转运蛋白 和去甲肾上腺素(NE)转运蛋白重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM |
||
S5071 |
DuloxetineDuloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake. |
||
S5506 |
VortioxetineVortioxetine, a novel antidepressant for the treatment of major depressive disorder, is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and serotonin (5-HT) transporter (SERT) inhibitor. |
||
S4377 |
Imipramine HClImipramine (Melipramine) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination). |
||
S5858 |
VilazodoneVilazodone (EMD-68843, SB-659746A)是一种新型抗抑郁剂,具有选择性5-HT再摄取抑制作用和部分5-HT1A受体激动活性。Vilazodone与5-HT重吸收位点的结合亲和力比与去甲肾上腺素和多巴胺位点结合亲和力高。 |
||
S6301New |
MPP+ iodideMPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide) 是神经毒素 MPTP 的代谢物,通过选择性破坏黑质中的多巴胺能神经元 dopaminergic neurons,在动物模型中引起帕金森病(PD)的症状。MPP+ iodide 在SH-SY5Y细胞中诱导 autophagic cell death。MPP+ iodide 在多巴胺能(DA)神经元中诱导 dopamine transporter (DAT) 的外化,但在血清素(5-HT)神经元中诱导 serotonin transporter (SERT) 的内化。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1627 |
Nitazoxanide (NSC 697855)Nitazoxanide (NSC 697855, NTZ)是一种人工合成的nitrothiazolyl-salicylamide衍生物,是一种抗原虫剂(作用于犬流感病毒,IC50为0.17 到0.21 μM)。Nitazoxanide 可调节自噬并抑制 mTORC1 信号传递。 |
||
S1441 |
Venlafaxine HClVenlafaxine HCl是一种5-羟色胺-去甲肾上腺素再摄取抑制剂(SNRI),用于治疗重度抑郁症,泛焦虑症,急性焦虑症以及社交恐惧症。 |
||
S3005 |
Paroxetine HClParoxetine HCl (BRL-29060A, FG-7051)是SSRI类抗抑郁药。 |
||
S1869 |
Dapoxetine HClDapoxetine HCl (LY-210448)是一种短效的,新型选择性5-羟色胺再摄取抑制剂。 |
||
S8021 |
Vortioxetine (Lu AA21004) HBrVortioxetine (Lu AA21004) 是一种多功能模式的羟色胺的药剂,它是 h5-HT3A receptor 和 h5-HT7 receptor 的拮抗剂,对应的Ki值分别为3.7 nM和19 nM。Vortioxetine (Lu AA21004)也是 h5-HT1B receptor 的部分激动剂、 h5-HT1A receptor 的激动剂和 human 5-HT transporter (SERT) 的抑制剂,对应的Ki值分别为33 nM、15 nM和1.6 nM。 |
||
S1336 |
Fluvoxamine (DU-23000) maleateFluvoxamine maleate (DU-23000, MK-264)是一种选择性5-羟色胺再摄取抑制剂(SSRI)。 |
||
S4053 |
Sertraline HClSertraline HCl (CP-51974-1) 是一种5-HT抑制剂, Ki值为13 nM. |
||
S2541 |
Clomipramine HClClomipramine HCl 是Clomipramine的盐酸盐,抑制5-羟色胺转运蛋白(SERT),去甲肾上腺素转运体(NET)和多巴胺转运蛋白(DAT),Ki分别为0.14, 54和3 nM。 |
||
S4113 |
DesvenlafaxineDesvenlafaxine (WY 45233 Succinate)是一种5-羟色胺(5-HT)和去甲肾上腺素(NE)重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM。 |
||
S4064 |
Escitalopram OxalateEscitalopram Oxalate是一种选择性的5-羟色胺(5-HT)重吸收抑制剂(SSRI),Ki值为0.89 nM. |
||
S2084 |
Duloxetine HClDuloxetine HCl (LY-248686)是一种5-羟色胺-去甲肾上腺素再摄取抑制剂,Ki为4.6 nM,用于治疗重度抑郁症和广泛性焦虑症(GAD)。 |
![]() ![]() Summarized results of dose-dependent effect of duloxetine on the following: (1) the capacity of the AA-irritated bladder and (2) PNS-induced increase in bladder capacity. |
|
S4259 |
Vilazodone HClVilazodone是一个组合的五羟色胺再摄取特定抑制剂(SSRI)和5-HT1A受体的部分激动剂,目前正在临床评估抑郁症的治疗。 |
||
S3140 |
Milnacipran HClMilnacipran HCl能抑制去甲肾上腺素转运蛋白(NET)和五羟色胺转运蛋白(SERT),其IC50分别是77 nM和420 Nm |
||
S3183 |
Amitriptyline HClAmitriptyline HCl 是一种 serotonin transporter (SERT) 和 norepinephrine transporter (NET) 的抑制剂,其Ki值分别为3.45 nM和13.3 nM。Amitriptyline HCl 还可抑制histamine receptor H1、histamine receptor H4、5-HT2 和 sigma 1 receptor,对应的Ki值分别是0.5 nM、7.31 nM、235 nM和287 nM。Amitriptyline 是一种三环抗抑郁药物。 |
||
S5239 |
Paroxetine mesylateParoxetine Mesylate is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. |
||
S5947 |
AmitriptylineAmitriptyline (MK-230, N-750, Ro41575) 是一种三环抗抑郁药,具有止痛效果,被广泛用于治疗抑郁和神经性疼痛。Amitriptyline 是一种 serotonin transporter (SERT) 和 norepinephrine transporter (NET) 的抑制剂,其Ki值分别为3.45 nM和13.3 nM。Amitriptyline 还可抑制histamine receptor H1、histamine receptor H4、5-HT2 和 sigma 1 receptor,对应的Ki值分别是0.5 nM、7.31 nM、235 nM和287 nM。该产品呈胶状。 |
||
S5693 |
Levomilnacipran HydrochlorideLevomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor with antidepressant activity. |
||
S2282 |
CinchonidineCinchonidine是一种生物碱,在有机化学中用于不对称合成。 |
||
S4749 |
Citalopram HBrCitalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr)是一种抗抑郁剂,是一种常用于口服途径的选择性serotonin reuptake抑制剂,IC50为1.8 nM。 |
||
S5655 |
VenlafaxineVenlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia. |
||
S5485 |
Desipramine HydrochlorideDesipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects. |
||
S4112 |
Desvenlafaxine SuccinateDesvenlafaxine Succinate (WY 45233) 是一种新型5-羟色胺(5-HT)转运蛋白 和去甲肾上腺素(NE)转运蛋白重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM |
||
S5071 |
DuloxetineDuloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake. |
||
S5506 |
VortioxetineVortioxetine, a novel antidepressant for the treatment of major depressive disorder, is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and serotonin (5-HT) transporter (SERT) inhibitor. |
||
S4377 |
Imipramine HClImipramine (Melipramine) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination). |
||
S5858 |
VilazodoneVilazodone (EMD-68843, SB-659746A)是一种新型抗抑郁剂,具有选择性5-HT再摄取抑制作用和部分5-HT1A受体激动活性。Vilazodone与5-HT重吸收位点的结合亲和力比与去甲肾上腺素和多巴胺位点结合亲和力高。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S6301New |
MPP+ iodideMPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide) 是神经毒素 MPTP 的代谢物,通过选择性破坏黑质中的多巴胺能神经元 dopaminergic neurons,在动物模型中引起帕金森病(PD)的症状。MPP+ iodide 在SH-SY5Y细胞中诱导 autophagic cell death。MPP+ iodide 在多巴胺能(DA)神经元中诱导 dopamine transporter (DAT) 的外化,但在血清素(5-HT)神经元中诱导 serotonin transporter (SERT) 的内化。 |