Serotonin Transporter

Serotonin Transporter产品

目录号	产品描述	文献引用	实验数据
S1627	Nitazoxanide (NSC 697855) Nitazoxanide (NSC 697855, NTZ)是一种人工合成的nitrothiazolyl-salicylamide衍生物，是一种抗原虫剂（作用于犬流感病毒，IC50为0.17 到0.21 μM）。Nitazoxanide 可调节自噬并抑制 mTORC1 信号传递。	Heliyon, 2021, 7(7):e07586 Biomedicines, 2021, 9(8)949 Biomed J, 2020, S2319-4170(20)30066-4
S1441	Venlafaxine HCl Venlafaxine HCl是一种5-羟色胺-去甲肾上腺素再摄取抑制剂（SNRI），用于治疗重度抑郁症，泛焦虑症，急性焦虑症以及社交恐惧症。	Nat Commun, 2020, 14;11(1):1825 Drug Metab Dispos, 2020, 48(10):1044-1052
S3005	Paroxetine HCl Paroxetine HCl (BRL-29060A, FG-7051)是SSRI类抗抑郁药。	Anal Methods, 2021, 10.1039/d0ay02027c
S1869	Dapoxetine HCl Dapoxetine HCl (LY-210448)是一种短效的，新型选择性5-羟色胺再摄取抑制剂。
S8021	Vortioxetine (Lu AA21004) HBr Vortioxetine (Lu AA21004) 是一种多功能模式的羟色胺的药剂，它是 h5-HT3A receptor 和 h5-HT7 receptor 的拮抗剂，对应的Ki值分别为3.7 nM和19 nM。Vortioxetine (Lu AA21004)也是 h5-HT1B receptor 的部分激动剂、 h5-HT1A receptor 的激动剂和 human 5-HT transporter (SERT) 的抑制剂，对应的Ki值分别为33 nM、15 nM和1.6 nM。
S1336	Fluvoxamine (DU-23000) maleate Fluvoxamine maleate (DU-23000, MK-264)是一种选择性5-羟色胺再摄取抑制剂(SSRI)。	bioRxiv, 2020, 2020.09.24.312165 Biol Open, 2020, bio.53363
S4053	Sertraline HCl Sertraline HCl (CP-51974-1) 是一种5-HT抑制剂， Ki值为13 nM.	Antimicrob Agents Chemother, 2021, AAC.01146-20 Sci Rep, 2021, 11(1):1250
S2541	Clomipramine HCl Clomipramine HCl 是Clomipramine的盐酸盐，抑制5-羟色胺转运蛋白（SERT），去甲肾上腺素转运体（NET）和多巴胺转运蛋白（DAT），Ki分别为0.14， 54和3 nM。	bioRxiv, 2020, 2020/9/20.4.7.30734
S4113	Desvenlafaxine Desvenlafaxine (WY 45233 Succinate)是一种5-羟色胺(5-HT)和去甲肾上腺素(NE)重吸收抑制剂，Ki值分别为40.2 nM和558.4 nM。	Drug Metab Dispos, 2020, 48(10):1044-1052
S4064	Escitalopram Oxalate Escitalopram Oxalate是一种选择性的5-羟色胺(5-HT)重吸收抑制剂(SSRI)，Ki值为0.89 nM.
S2084	Duloxetine HCl Duloxetine HCl (LY-248686)是一种5-羟色胺-去甲肾上腺素再摄取抑制剂，Ki为4.6 nM，用于治疗重度抑郁症和广泛性焦虑症（GAD）。	Drug Metab Dispos, 2015, 44(3):378-88 J Pharmacol Exp Ther, 2014, 349(3):402-7 Am J Physiol Renal Physiol, 2013, 305(12):F1663-8	Summarized results of dose-dependent effect of duloxetine on the following: (1) the capacity of the AA-irritated bladder and (2) PNS-induced increase in bladder capacity.
S4259	Vilazodone HCl Vilazodone是一个组合的五羟色胺再摄取特定抑制剂（SSRI）和5-HT1A受体的部分激动剂，目前正在临床评估抑郁症的治疗。	J Pain, 2019, 20(1):16.e1-16.e16 Acta Pol Pharm, 2017, 74(3):765-775
S3140	Milnacipran HCl Milnacipran HCl能抑制去甲肾上腺素转运蛋白(NET)和五羟色胺转运蛋白(SERT)，其IC50分别是77 nM和420 Nm
S3183	Amitriptyline HCl Amitriptyline HCl 是一种 serotonin transporter (SERT) 和 norepinephrine transporter (NET) 的抑制剂，其Ki值分别为3.45 nM和13.3 nM。Amitriptyline HCl 还可抑制histamine receptor H1、histamine receptor H4、5-HT2 和 sigma 1 receptor，对应的Ki值分别是0.5 nM、7.31 nM、235 nM和287 nM。Amitriptyline 是一种三环抗抑郁药物。	Environ Toxicol Chem, 2021, 10.1002/etc.5018 PLoS Pathog, 2020, 16;16(3):e1008341 Sci Rep, 2018, 8(1):15753
S5239	Paroxetine mesylate Paroxetine Mesylate is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.	Anal Methods, 2021, 10.1039/d0ay02027c
S5947	Amitriptyline Amitriptyline (MK-230, N-750, Ro41575) 是一种三环抗抑郁药，具有止痛效果，被广泛用于治疗抑郁和神经性疼痛。Amitriptyline 是一种 serotonin transporter (SERT) 和 norepinephrine transporter (NET) 的抑制剂，其Ki值分别为3.45 nM和13.3 nM。Amitriptyline 还可抑制histamine receptor H1、histamine receptor H4、5-HT2 和 sigma 1 receptor，对应的Ki值分别是0.5 nM、7.31 nM、235 nM和287 nM。该产品呈胶状。	Cancers (Basel), 2019, 11(12)
S5693	Levomilnacipran Hydrochloride Levomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor with antidepressant activity.
S2282	Cinchonidine Cinchonidine是一种生物碱，在有机化学中用于不对称合成。	J Med Virol, 2019, 91(8):1440-1447
S4749	Citalopram HBr Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr)是一种抗抑郁剂，是一种常用于口服途径的选择性serotonin reuptake抑制剂，IC50为1.8 nM。	Aging (Albany NY), 2021, 13(11):14729-14744 Sci Rep, 2021, 11(1):1250 Aging (Albany NY), 2020, 12(11):10147-10161
S5655	Venlafaxine Venlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.
S5485	Desipramine Hydrochloride Desipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects.
S4112	Desvenlafaxine Succinate Desvenlafaxine Succinate (WY 45233) 是一种新型5-羟色胺(5-HT)转运蛋白 和去甲肾上腺素(NE)转运蛋白重吸收抑制剂，Ki值分别为40.2 nM和558.4 nM	Drug Metab Dispos, 2020, 48(10):1044-1052
S5071	Duloxetine Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake.
S5506	Vortioxetine Vortioxetine, a novel antidepressant for the treatment of major depressive disorder, is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and serotonin (5-HT) transporter (SERT) inhibitor.
S4377	Imipramine HCl Imipramine (Melipramine) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).
S5858	Vilazodone Vilazodone (EMD-68843, SB-659746A)是一种新型抗抑郁剂，具有选择性5-HT再摄取抑制作用和部分5-HT1A受体激动活性。Vilazodone与5-HT重吸收位点的结合亲和力比与去甲肾上腺素和多巴胺位点结合亲和力高。	J Pain, 2019, 20(1):16.e1-16.e16
S6301New	MPP+ iodide MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide) 是神经毒素 MPTP 的代谢物，通过选择性破坏黑质中的多巴胺能神经元 dopaminergic neurons，在动物模型中引起帕金森病(PD)的症状。MPP+ iodide 在SH-SY5Y细胞中诱导 autophagic cell death。MPP+ iodide 在多巴胺能(DA)神经元中诱导 dopamine transporter (DAT) 的外化，但在血清素(5-HT)神经元中诱导 serotonin transporter (SERT) 的内化。

目录号	产品描述	文献引用	实验数据
S1627	Nitazoxanide (NSC 697855) Nitazoxanide (NSC 697855, NTZ)是一种人工合成的nitrothiazolyl-salicylamide衍生物，是一种抗原虫剂（作用于犬流感病毒，IC50为0.17 到0.21 μM）。Nitazoxanide 可调节自噬并抑制 mTORC1 信号传递。	Heliyon,2021, 7(7):e07586 Biomedicines,2021, 9(8)949 Biomed J,2020, S2319-4170(20)30066-4
S1441	Venlafaxine HCl Venlafaxine HCl是一种5-羟色胺-去甲肾上腺素再摄取抑制剂（SNRI），用于治疗重度抑郁症，泛焦虑症，急性焦虑症以及社交恐惧症。	Nat Commun,2020, 14;11(1):1825 Drug Metab Dispos,2020, 48(10):1044-1052
S3005	Paroxetine HCl Paroxetine HCl (BRL-29060A, FG-7051)是SSRI类抗抑郁药。	Anal Methods,2021, 10.1039/d0ay02027c
S1869	Dapoxetine HCl Dapoxetine HCl (LY-210448)是一种短效的，新型选择性5-羟色胺再摄取抑制剂。
S8021	Vortioxetine (Lu AA21004) HBr Vortioxetine (Lu AA21004) 是一种多功能模式的羟色胺的药剂，它是 h5-HT3A receptor 和 h5-HT7 receptor 的拮抗剂，对应的Ki值分别为3.7 nM和19 nM。Vortioxetine (Lu AA21004)也是 h5-HT1B receptor 的部分激动剂、 h5-HT1A receptor 的激动剂和 human 5-HT transporter (SERT) 的抑制剂，对应的Ki值分别为33 nM、15 nM和1.6 nM。
S1336	Fluvoxamine (DU-23000) maleate Fluvoxamine maleate (DU-23000, MK-264)是一种选择性5-羟色胺再摄取抑制剂(SSRI)。	bioRxiv,2020, 2020.09.24.312165 Biol Open,2020, bio.53363
S4053	Sertraline HCl Sertraline HCl (CP-51974-1) 是一种5-HT抑制剂， Ki值为13 nM.	Antimicrob Agents Chemother,2021, AAC.01146-20 Sci Rep,2021, 11(1):1250
S2541	Clomipramine HCl Clomipramine HCl 是Clomipramine的盐酸盐，抑制5-羟色胺转运蛋白（SERT），去甲肾上腺素转运体（NET）和多巴胺转运蛋白（DAT），Ki分别为0.14， 54和3 nM。	bioRxiv,2020, 2020/9/20.4.7.30734
S4113	Desvenlafaxine Desvenlafaxine (WY 45233 Succinate)是一种5-羟色胺(5-HT)和去甲肾上腺素(NE)重吸收抑制剂，Ki值分别为40.2 nM和558.4 nM。	Drug Metab Dispos,2020, 48(10):1044-1052
S4064	Escitalopram Oxalate Escitalopram Oxalate是一种选择性的5-羟色胺(5-HT)重吸收抑制剂(SSRI)，Ki值为0.89 nM.
S2084	Duloxetine HCl Duloxetine HCl (LY-248686)是一种5-羟色胺-去甲肾上腺素再摄取抑制剂，Ki为4.6 nM，用于治疗重度抑郁症和广泛性焦虑症（GAD）。	Drug Metab Dispos,2015, 44(3):378-88 J Pharmacol Exp Ther,2014, 349(3):402-7 Am J Physiol Renal Physiol,2013, 305(12):F1663-8	Summarized results of dose-dependent effect of duloxetine on the following: (1) the capacity of the AA-irritated bladder and (2) PNS-induced increase in bladder capacity.
S4259	Vilazodone HCl Vilazodone是一个组合的五羟色胺再摄取特定抑制剂（SSRI）和5-HT1A受体的部分激动剂，目前正在临床评估抑郁症的治疗。	J Pain,2019, 20(1):16.e1-16.e16 Acta Pol Pharm,2017, 74(3):765-775
S3140	Milnacipran HCl Milnacipran HCl能抑制去甲肾上腺素转运蛋白(NET)和五羟色胺转运蛋白(SERT)，其IC50分别是77 nM和420 Nm
S3183	Amitriptyline HCl Amitriptyline HCl 是一种 serotonin transporter (SERT) 和 norepinephrine transporter (NET) 的抑制剂，其Ki值分别为3.45 nM和13.3 nM。Amitriptyline HCl 还可抑制histamine receptor H1、histamine receptor H4、5-HT2 和 sigma 1 receptor，对应的Ki值分别是0.5 nM、7.31 nM、235 nM和287 nM。Amitriptyline 是一种三环抗抑郁药物。	Environ Toxicol Chem,2021, 10.1002/etc.5018 PLoS Pathog,2020, 16;16(3):e1008341 Sci Rep,2018, 8(1):15753
S5239	Paroxetine mesylate Paroxetine Mesylate is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.	Anal Methods,2021, 10.1039/d0ay02027c
S5947	Amitriptyline Amitriptyline (MK-230, N-750, Ro41575) 是一种三环抗抑郁药，具有止痛效果，被广泛用于治疗抑郁和神经性疼痛。Amitriptyline 是一种 serotonin transporter (SERT) 和 norepinephrine transporter (NET) 的抑制剂，其Ki值分别为3.45 nM和13.3 nM。Amitriptyline 还可抑制histamine receptor H1、histamine receptor H4、5-HT2 和 sigma 1 receptor，对应的Ki值分别是0.5 nM、7.31 nM、235 nM和287 nM。该产品呈胶状。	Cancers (Basel),2019, 11(12)
S5693	Levomilnacipran Hydrochloride Levomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor with antidepressant activity.
S2282	Cinchonidine Cinchonidine是一种生物碱，在有机化学中用于不对称合成。	J Med Virol,2019, 91(8):1440-1447
S4749	Citalopram HBr Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr)是一种抗抑郁剂，是一种常用于口服途径的选择性serotonin reuptake抑制剂，IC50为1.8 nM。	Aging (Albany NY),2021, 13(11):14729-14744 Sci Rep,2021, 11(1):1250 Aging (Albany NY),2020, 12(11):10147-10161
S5655	Venlafaxine Venlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.
S5485	Desipramine Hydrochloride Desipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects.
S4112	Desvenlafaxine Succinate Desvenlafaxine Succinate (WY 45233) 是一种新型5-羟色胺(5-HT)转运蛋白 和去甲肾上腺素(NE)转运蛋白重吸收抑制剂，Ki值分别为40.2 nM和558.4 nM	Drug Metab Dispos,2020, 48(10):1044-1052
S5071	Duloxetine Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake.
S5506	Vortioxetine Vortioxetine, a novel antidepressant for the treatment of major depressive disorder, is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and serotonin (5-HT) transporter (SERT) inhibitor.
S4377	Imipramine HCl Imipramine (Melipramine) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).
S5858	Vilazodone Vilazodone (EMD-68843, SB-659746A)是一种新型抗抑郁剂，具有选择性5-HT再摄取抑制作用和部分5-HT1A受体激动活性。Vilazodone与5-HT重吸收位点的结合亲和力比与去甲肾上腺素和多巴胺位点结合亲和力高。	J Pain,2019, 20(1):16.e1-16.e16

目录号	产品描述	文献引用	实验数据
S6301New	MPP+ iodide MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide) 是神经毒素 MPTP 的代谢物，通过选择性破坏黑质中的多巴胺能神经元 dopaminergic neurons，在动物模型中引起帕金森病(PD)的症状。MPP+ iodide 在SH-SY5Y细胞中诱导 autophagic cell death。MPP+ iodide 在多巴胺能(DA)神经元中诱导 dopamine transporter (DAT) 的外化，但在血清素(5-HT)神经元中诱导 serotonin transporter (SERT) 的内化。