Sodium Channel
Sodium Channel产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S1614 |
RiluzoleRiluzole (RP-54274, PK 26124) 是谷氨酸盐释放抑制剂,具有神经保护、抗癫痫、抗焦虑以及麻醉作用。 |
![]() ![]() Spatial memory performance. a Latency to find the hidden platform. LPS-infused controls and Aged controls were impaired (*p<0.001) compared to young aCSF-infused rats. The performance of Aged rats improved across days only when treated with Ril (†t=0.035). b Distance. LPS controls swam a greater distance than aCSF controls and Aged controls (*p≤0.036). c Swim Speed. Aged rats swam the
most slowly (*p≤0.001). d Thigmotaxis. Aged controls spent the greatest percentage of time within the pool perimeter (*p<0.001).
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S2454 |
Bupivacaine HClBupivacaine HCl 可以与钠离子通道的胞内部分结合从而阻断进入神经细胞的钠离子流, 用于治疗心律不齐。 |
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S1811 |
Amiloride HClAmiloride (MK-870)是一种选择性的T-type calcium channel阻滞剂,epithelial sodium channel(ENaC)阻滞剂,urokinase plasminogen activator (uPA)抑制剂,Ki=7 μM。 |
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S1256 |
RufinamideRufinamide (CGP 33101)是一种电压门控式的sodium channel阻断剂,用作抗惊厥的药物。 |
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S1445 |
ZonisamideZonisamide (CI-912)是FDA批准的抗癫痫药物,阻断电压依赖性钠(+)通道和T型钙离子通道。 |
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S6920New |
SEA0400SEA0400 是一种选择性的 Na+-Ca2+ exchanger (NCX) 的强效抑制剂,可抑制神经细胞、星形胶质细胞和小胶质细胞中Na+依赖性的Ca2+吸收,对应的IC50值分别为33 nM、5.0 nM和8.3 nM。SEA0400 可防止硝普钠 (SNP) 提高 ERK 和 p38 MAPK 的磷酸化和通过细胞外Ca2+依赖的方式增强reactive oxygen species (ROS) 的产生。 |
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S4339New |
MeticraneMeticrane 是一种利尿剂,可抑制远曲小管中 reabsorption of sodium and chloride ions 的重吸收。Meticrane 可用于治疗原发性高血压。 |
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S2524 |
Phenytoin SodiumPhenytoin Sodium (Diphenylhydantoin)是一种失活的电压门控钠离子通道稳定剂。 |
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S1693 |
CarbamazepineCarbamazepine (Carbatrol, NSC 169864) 是一种钠离子通道抑制剂,作用于大鼠脑突触体时, IC50为131 μM。 |
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S2785 |
A-803467A-803467是一种选择性NaV1.8 channel抑制剂,IC50为8 nM,抑制抗河豚毒的电流,比作用于人类NaV1.2, NaV1.3, NaV1.5和NaV1.7选择性高100倍以上。 |
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S2560 |
Amiloride HCl dihydrateAmiloride HCl dihydrate是一种有效的上皮细胞钠离子通道抑制剂。 |
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S2525 |
PhenytoinPhenytoin (Diphenylhydantoin) 是一种失活的电压门控钠离子通道稳定剂。 |
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S2874 |
Camostat MesilateCamostat (FOY-305, FOY-S980)是胰蛋白酶样的蛋白酶抑制剂,抑制上皮细胞钠离子通道(ENaC)功能,IC50为50 nM, 对Trypsin, Prostasin 和 Matriptase作用效果稍弱。 |
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S2114 |
Dronedarone HClDronedarone HCl (SR33589) 用于治疗阵发性和持续性房颤或房扑的患者。 |
![]() ![]() Results of hit validation experiments for these four compounds for animals treated at L1 stage at four different concentrations (0.5, 5, 25, and 50 μM). The blue bars represent the values obtained from the original screen as reference points. Error bars are standard error of the mean. Statistical significance for all different doses for individual compounds was calculated with respect to the lowest concentration using two-tailed, t-test (nZ70 animals except n = 37 for Geld 25 μM). The statistical significance values are represented as P<0.05 (*) and P<0.005 (**).
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S3024 |
LamotrigineLamotrigine (BW-430C)是一种新型抗惊厥药剂,作用于人类血小板和大鼠脑突触体,抑制5-羟色胺(5-HT)吸收,IC50分别为240 μM和474 μM。 |
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S1965 |
PrimidonePrimidone (NCI-C56360) 是一种嘧啶二酮类抗惊厥药。 |
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S3064 |
Ambroxol HClAmbroxol HCl是有效的神经性钠离子通道抑制剂,抑制抗TTX的钠离子电流,相位性阻滞,IC50为22.5 μM,抑制对TTX敏感的钠离子电流,IC50为100 μM。Phase 3。 |
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S2041 |
Dyclonine HClDyclonine HCl是Dyclonine的盐酸盐形式,是一种口服麻醉剂。Dyclonine可逆地与神经元细胞膜上活化的钠离子通道结合,减少神经元膜对钠离子的通透性。 |
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S4229 |
Oxybuprocaine HClOxybuprocaine HCl是一种局部麻醉剂,尤其在眼科与耳鼻咽喉科使用。其与钠离子通道结合,可逆地稳定神经元细胞膜,减少其对钠离子的通透性。 |
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S3155 |
Mepivacaine HClMepivacaine 是一种叔胺,用作局部麻醉剂。 |
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S2500 |
Propafenone HClPropafenone HCl是一种典型的抗心律失常药物,用于治疗与心跳加速相关的疾病,如心房和心室心律失常。 |
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S9142 |
SparteineSparteine, which could be extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent. |
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S4023 |
Procaine HClProcaine (Novocaine) 是一种钠离子通道的,NMDA受体以及乙酰胆碱受体抑制剂, IC50分别为60 μM, 0.296 mM何45.5 μM,也是一种,5-HT3抑制剂,KD为1.7 μM。 |
![]() ![]() Procaine pretreatment inhibits JAK2 and STAT3 expression. (A) Relative Jak2 mRNA level detected by qRT-PCR. (B) Relative Stat3 mRNA level detected by qRT-PCR. (C) JAK2 and STAT3 protein expression detected by western blot. (D) Relative protein levels of JAK2 and STAT3 based on Western blot results. sham, rats undergone sham surgery. CCI, rats undergone sciatic nerve chronic compression injury (CCI) as the neuropathic pain (NPP) model. CCI+procaine, NPP model rats pretreated with procaine. The detection is performed on the 20th day post surgery (n=3). GAPDH is used as an internal reference. *p<0.05, **p<0.01. JAK2, Janus kinase 2. STAT3, signal transducer and activator of transcription 3.
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S1619 |
PrilocainePrilocaine (NSC 40027) 是一种氨基酰胺类的局部麻醉剂。它作用于神经元细胞膜上的钠离子通道,限制癫痫发作的扩散。 |
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S5556 |
(-)-Sparteine SulfateSparteine Sulfate, a quinolizidine alkaloid, is the sulfate form of sparteini, which is a sodium channel blocker used as an oxytocic and an anti-arrhythmia agent. |
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S5274 |
GS967GS967 (GS458967) is a potent and selective inhibitor of late INa with anti-arrhythmic actions. |
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S4038 |
Dibucaine HClDibucaine HCl (Cinchocaine) 是一种局部麻醉剂。 |
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S5490 |
DisopyramideDisopyramide is a class IA antiarrhythmic drug which acts via blockade of sodium channels depressing phase 0 of the action potential. Disopyramide possesses significant negative inotropic, anticholinergic effects and enhances AV nodal conduction. |
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S1391 |
OxcarbazepineOxcarbazepine (GP47680) 是一种抗惊厥和稳定情绪的药物。抑制[3H]BTX与sodium channels结合, IC50位160 μM,也抑制22Na+汇入大鼠脑i突触体, IC50约为100 μM。 |
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S4657 |
Eslicarbazepine AcetateEslicarbazepine Acetate (BIA 2093, Zebinix, Exalief, Stedesa, Aptiom) 是一种抗癫痫药物。 |
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S4058 |
Ropivacaine HClRopivacaine HCl (LEA-103) 是一种麻醉剂,通过可逆地抑制钠离子流入来阻断神经纤维上冲动的传导。 |
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S4180 |
Nefopam HClNefopam HCl是一种中枢作用剂,但是是非阿片类的镇痛药,抑制电压门控钠通道,及抑制5-羟色胺,多巴胺和去甲肾上腺素的再吸收。 |
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S4061 |
Levobupivacaine HClLevobupivacaine HCl ((S)-(-)-Bupivacaine),丁哌卡因的纯净S(-)-对映体,是一种可逆神经元的sodium channel抑制剂,用作长效局部麻醉剂。 |
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S5814 |
cariporideCariporide是有效的选择性NHE1抑制剂,在CHO-K1细胞中对hNHE1的IC50值为30 nM。 |
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S4080 |
TriamtereneTriamterene (SKF8542) 以电压依赖方式阻断上皮细胞钠离子通道(ENaC),IC50值为4.5 μM. |
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S5710 |
AmbroxolAmbroxol, a substituted benzylamine, is an active metabolite of bromhexine. It is a potent inhibitor of the neuronal Na+ channels. |
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S2318 |
LappaconitineLappaconitine (LC) is a natural diterpenoid alkaloid (DTA), acting as a human heart sodium channel blocker and possessing a wide range of biological activities, including anti-arrhythmic, anti-inflammatory, antioxidative, anticancer, epileptiform etc. |
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S4200 |
Tolperisone HClTolperisone HCl是一种离子通道抑制剂和中枢性肌肉松弛剂。 |
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S4210 |
BenzocaineBenzocaine 是对氨基苯甲酸乙酯 (PABA), 是一种局部麻醉剂,用作外用止痛药或常用于止咳。 |
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S4669 |
Benzocaine hydrochlorideBenzocaine hydrochloride (Ethyl 4-aminobenzoate, Ethyl p-aminobenzoate)是一种表面麻醉剂,通过阻止沿着神经纤维及在神经末梢的脉冲传播发挥作用。 |
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S4668 |
ProcaineProcaine (Novocaine, Vitamin H3, Duracaine, Spinocaine) 是苯甲酸类化合物,具有局部麻醉和抗心律失常的活性。Procaine结合并抑制电压依赖性钠离子通道,因而抑制脉冲起始和传导所需的离子通量。 |
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S4225 |
Mexiletine HClMexiletine HCl (KO1173)属于IB类抗心律失常药,抑制钠离子通道,降低内流钠电流。 |
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S4235 |
Phenazopyridine HClPhenazopyridine HCl是一种局部镇痛剂,已被用于治疗泌尿系统疾病。它是sodium channel protein type 1 subunit alpha的抑制剂。 |
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S3751 |
Quinidine sulfateQuinidine (Chinidin, Pitayine, β-quinine, (+)-quinidine)可抑制电压依赖性钠离子通道,同时也具有抗毒蕈碱和抗疟疾活性。 |
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S0016 |
SN-6SN-6 是一种选择性的 Na+/Ca2+ exchanger (NCX) 抑制剂。SN-6 可抑制NCX1、NCX2和NCX3,对应的IC50值分别为2.9 μM、16 μM和8.6 μM。SN-6 可消除 acetylcholine (ACh) 诱导的血管舒张。 |
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S3907 |
Bulleyaconi cine ABulleyaconi cine A (Bulleyaconitine A, BLA) is an active ingredient of Aconitum bulleyanum plants and classified as an "aconitine-like" alkaloid. It is a potent use-dependent blocker for both Nav1.7 and Nav1.8 Na+ currents. |
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S4284 |
Chloroprocaine HClChloroprocaine HCl 是手术治疗中的局部麻醉剂。 |
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S5749 |
ChlorpromazineChlorpromazine (CPZ) 是一种低效的典型抗精神病药,用于治疗精神病如精神分裂症。Chlorpromazine (CPZ) 在体外可抑制 5-HT(2A) receptor 和 dopamine D2。Chlorpromazine (CPZ) 还可抑制 sodium channel,并阻断HERG potassium channels,对应的IC50值为21.6 μM。 |
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S2110 |
VinpocetineVinpocetine (RGH-4405)选择性抑制电压敏感型钠离子通道,用于治疗中风,血管性痴呆和阿尔茨海默症。 |
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S2118 |
Ibutilide FumarateIbutilide Fumarate (U-70226E)是第三类抗心律失常药物,主要用于急性新梗阻的心房颤动(房颤)/心房扑动(房扑),适用于近期发作的房颤或房扑逆转成窦性心律,向内钠电流感应缓慢,这会延长心肌细胞的动作电位和不应期。 |
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S4294 |
Procainamide HClProcainamide HCl是一种sodium channel的阻断剂,也是DNA甲基转移酶抑制剂,用于心律失常的治疗。 |
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S3250New |
VeratrineVeratridine (Cevadine, Cevadin, Cevadene)是一种在百合科植物中发现的甾体生物碱,是 voltage-gated sodium channel 活化剂。Veratridine 会在大鼠中诱发类似焦虑的行为。 |
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S3911 |
VeratramineVeratramine (NSC 17821, NSC 23880), a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. It is a good membrane permeant, undergoes rapid passive diffusion, and has a good stability in the gastrointestinal tract during its absorption. |
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S1828 |
Proparacaine HClProparacaine HCl是电压门控的钠离子通道的拮抗剂,ED50是3.4 mM。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1614 |
RiluzoleRiluzole (RP-54274, PK 26124) 是谷氨酸盐释放抑制剂,具有神经保护、抗癫痫、抗焦虑以及麻醉作用。 |
![]() ![]() Spatial memory performance. a Latency to find the hidden platform. LPS-infused controls and Aged controls were impaired (*p<0.001) compared to young aCSF-infused rats. The performance of Aged rats improved across days only when treated with Ril (†t=0.035). b Distance. LPS controls swam a greater distance than aCSF controls and Aged controls (*p≤0.036). c Swim Speed. Aged rats swam the
most slowly (*p≤0.001). d Thigmotaxis. Aged controls spent the greatest percentage of time within the pool perimeter (*p<0.001).
|
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S2454 |
Bupivacaine HClBupivacaine HCl 可以与钠离子通道的胞内部分结合从而阻断进入神经细胞的钠离子流, 用于治疗心律不齐。 |
||
S1811 |
Amiloride HClAmiloride (MK-870)是一种选择性的T-type calcium channel阻滞剂,epithelial sodium channel(ENaC)阻滞剂,urokinase plasminogen activator (uPA)抑制剂,Ki=7 μM。 |
||
S1256 |
RufinamideRufinamide (CGP 33101)是一种电压门控式的sodium channel阻断剂,用作抗惊厥的药物。 |
||
S1445 |
ZonisamideZonisamide (CI-912)是FDA批准的抗癫痫药物,阻断电压依赖性钠(+)通道和T型钙离子通道。 |
||
S6920New |
SEA0400SEA0400 是一种选择性的 Na+-Ca2+ exchanger (NCX) 的强效抑制剂,可抑制神经细胞、星形胶质细胞和小胶质细胞中Na+依赖性的Ca2+吸收,对应的IC50值分别为33 nM、5.0 nM和8.3 nM。SEA0400 可防止硝普钠 (SNP) 提高 ERK 和 p38 MAPK 的磷酸化和通过细胞外Ca2+依赖的方式增强reactive oxygen species (ROS) 的产生。 |
||
S4339New |
MeticraneMeticrane 是一种利尿剂,可抑制远曲小管中 reabsorption of sodium and chloride ions 的重吸收。Meticrane 可用于治疗原发性高血压。 |
||
S2524 |
Phenytoin SodiumPhenytoin Sodium (Diphenylhydantoin)是一种失活的电压门控钠离子通道稳定剂。 |
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S1693 |
CarbamazepineCarbamazepine (Carbatrol, NSC 169864) 是一种钠离子通道抑制剂,作用于大鼠脑突触体时, IC50为131 μM。 |
||
S2785 |
A-803467A-803467是一种选择性NaV1.8 channel抑制剂,IC50为8 nM,抑制抗河豚毒的电流,比作用于人类NaV1.2, NaV1.3, NaV1.5和NaV1.7选择性高100倍以上。 |
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S2560 |
Amiloride HCl dihydrateAmiloride HCl dihydrate是一种有效的上皮细胞钠离子通道抑制剂。 |
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S2525 |
PhenytoinPhenytoin (Diphenylhydantoin) 是一种失活的电压门控钠离子通道稳定剂。 |
||
S2874 |
Camostat MesilateCamostat (FOY-305, FOY-S980)是胰蛋白酶样的蛋白酶抑制剂,抑制上皮细胞钠离子通道(ENaC)功能,IC50为50 nM, 对Trypsin, Prostasin 和 Matriptase作用效果稍弱。 |
||
S2114 |
Dronedarone HClDronedarone HCl (SR33589) 用于治疗阵发性和持续性房颤或房扑的患者。 |
![]() ![]() Results of hit validation experiments for these four compounds for animals treated at L1 stage at four different concentrations (0.5, 5, 25, and 50 μM). The blue bars represent the values obtained from the original screen as reference points. Error bars are standard error of the mean. Statistical significance for all different doses for individual compounds was calculated with respect to the lowest concentration using two-tailed, t-test (nZ70 animals except n = 37 for Geld 25 μM). The statistical significance values are represented as P<0.05 (*) and P<0.005 (**).
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S3024 |
LamotrigineLamotrigine (BW-430C)是一种新型抗惊厥药剂,作用于人类血小板和大鼠脑突触体,抑制5-羟色胺(5-HT)吸收,IC50分别为240 μM和474 μM。 |
||
S1965 |
PrimidonePrimidone (NCI-C56360) 是一种嘧啶二酮类抗惊厥药。 |
||
S3064 |
Ambroxol HClAmbroxol HCl是有效的神经性钠离子通道抑制剂,抑制抗TTX的钠离子电流,相位性阻滞,IC50为22.5 μM,抑制对TTX敏感的钠离子电流,IC50为100 μM。Phase 3。 |
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S2041 |
Dyclonine HClDyclonine HCl是Dyclonine的盐酸盐形式,是一种口服麻醉剂。Dyclonine可逆地与神经元细胞膜上活化的钠离子通道结合,减少神经元膜对钠离子的通透性。 |
||
S4229 |
Oxybuprocaine HClOxybuprocaine HCl是一种局部麻醉剂,尤其在眼科与耳鼻咽喉科使用。其与钠离子通道结合,可逆地稳定神经元细胞膜,减少其对钠离子的通透性。 |
||
S3155 |
Mepivacaine HClMepivacaine 是一种叔胺,用作局部麻醉剂。 |
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S2500 |
Propafenone HClPropafenone HCl是一种典型的抗心律失常药物,用于治疗与心跳加速相关的疾病,如心房和心室心律失常。 |
||
S9142 |
SparteineSparteine, which could be extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent. |
||
S4023 |
Procaine HClProcaine (Novocaine) 是一种钠离子通道的,NMDA受体以及乙酰胆碱受体抑制剂, IC50分别为60 μM, 0.296 mM何45.5 μM,也是一种,5-HT3抑制剂,KD为1.7 μM。 |
![]() ![]() Procaine pretreatment inhibits JAK2 and STAT3 expression. (A) Relative Jak2 mRNA level detected by qRT-PCR. (B) Relative Stat3 mRNA level detected by qRT-PCR. (C) JAK2 and STAT3 protein expression detected by western blot. (D) Relative protein levels of JAK2 and STAT3 based on Western blot results. sham, rats undergone sham surgery. CCI, rats undergone sciatic nerve chronic compression injury (CCI) as the neuropathic pain (NPP) model. CCI+procaine, NPP model rats pretreated with procaine. The detection is performed on the 20th day post surgery (n=3). GAPDH is used as an internal reference. *p<0.05, **p<0.01. JAK2, Janus kinase 2. STAT3, signal transducer and activator of transcription 3.
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S1619 |
PrilocainePrilocaine (NSC 40027) 是一种氨基酰胺类的局部麻醉剂。它作用于神经元细胞膜上的钠离子通道,限制癫痫发作的扩散。 |
||
S5556 |
(-)-Sparteine SulfateSparteine Sulfate, a quinolizidine alkaloid, is the sulfate form of sparteini, which is a sodium channel blocker used as an oxytocic and an anti-arrhythmia agent. |
||
S5274 |
GS967GS967 (GS458967) is a potent and selective inhibitor of late INa with anti-arrhythmic actions. |
||
S4038 |
Dibucaine HClDibucaine HCl (Cinchocaine) 是一种局部麻醉剂。 |
||
S5490 |
DisopyramideDisopyramide is a class IA antiarrhythmic drug which acts via blockade of sodium channels depressing phase 0 of the action potential. Disopyramide possesses significant negative inotropic, anticholinergic effects and enhances AV nodal conduction. |
||
S1391 |
OxcarbazepineOxcarbazepine (GP47680) 是一种抗惊厥和稳定情绪的药物。抑制[3H]BTX与sodium channels结合, IC50位160 μM,也抑制22Na+汇入大鼠脑i突触体, IC50约为100 μM。 |
||
S4657 |
Eslicarbazepine AcetateEslicarbazepine Acetate (BIA 2093, Zebinix, Exalief, Stedesa, Aptiom) 是一种抗癫痫药物。 |
||
S4058 |
Ropivacaine HClRopivacaine HCl (LEA-103) 是一种麻醉剂,通过可逆地抑制钠离子流入来阻断神经纤维上冲动的传导。 |
||
S4180 |
Nefopam HClNefopam HCl是一种中枢作用剂,但是是非阿片类的镇痛药,抑制电压门控钠通道,及抑制5-羟色胺,多巴胺和去甲肾上腺素的再吸收。 |
||
S4061 |
Levobupivacaine HClLevobupivacaine HCl ((S)-(-)-Bupivacaine),丁哌卡因的纯净S(-)-对映体,是一种可逆神经元的sodium channel抑制剂,用作长效局部麻醉剂。 |
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S5814 |
cariporideCariporide是有效的选择性NHE1抑制剂,在CHO-K1细胞中对hNHE1的IC50值为30 nM。 |
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S4080 |
TriamtereneTriamterene (SKF8542) 以电压依赖方式阻断上皮细胞钠离子通道(ENaC),IC50值为4.5 μM. |
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S5710 |
AmbroxolAmbroxol, a substituted benzylamine, is an active metabolite of bromhexine. It is a potent inhibitor of the neuronal Na+ channels. |
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S2318 |
LappaconitineLappaconitine (LC) is a natural diterpenoid alkaloid (DTA), acting as a human heart sodium channel blocker and possessing a wide range of biological activities, including anti-arrhythmic, anti-inflammatory, antioxidative, anticancer, epileptiform etc. |
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S4200 |
Tolperisone HClTolperisone HCl是一种离子通道抑制剂和中枢性肌肉松弛剂。 |
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S4210 |
BenzocaineBenzocaine 是对氨基苯甲酸乙酯 (PABA), 是一种局部麻醉剂,用作外用止痛药或常用于止咳。 |
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S4669 |
Benzocaine hydrochlorideBenzocaine hydrochloride (Ethyl 4-aminobenzoate, Ethyl p-aminobenzoate)是一种表面麻醉剂,通过阻止沿着神经纤维及在神经末梢的脉冲传播发挥作用。 |
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S4668 |
ProcaineProcaine (Novocaine, Vitamin H3, Duracaine, Spinocaine) 是苯甲酸类化合物,具有局部麻醉和抗心律失常的活性。Procaine结合并抑制电压依赖性钠离子通道,因而抑制脉冲起始和传导所需的离子通量。 |
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S4225 |
Mexiletine HClMexiletine HCl (KO1173)属于IB类抗心律失常药,抑制钠离子通道,降低内流钠电流。 |
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S4235 |
Phenazopyridine HClPhenazopyridine HCl是一种局部镇痛剂,已被用于治疗泌尿系统疾病。它是sodium channel protein type 1 subunit alpha的抑制剂。 |
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S3751 |
Quinidine sulfateQuinidine (Chinidin, Pitayine, β-quinine, (+)-quinidine)可抑制电压依赖性钠离子通道,同时也具有抗毒蕈碱和抗疟疾活性。 |
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S0016 |
SN-6SN-6 是一种选择性的 Na+/Ca2+ exchanger (NCX) 抑制剂。SN-6 可抑制NCX1、NCX2和NCX3,对应的IC50值分别为2.9 μM、16 μM和8.6 μM。SN-6 可消除 acetylcholine (ACh) 诱导的血管舒张。 |
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S3907 |
Bulleyaconi cine ABulleyaconi cine A (Bulleyaconitine A, BLA) is an active ingredient of Aconitum bulleyanum plants and classified as an "aconitine-like" alkaloid. It is a potent use-dependent blocker for both Nav1.7 and Nav1.8 Na+ currents. |
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S4284 |
Chloroprocaine HClChloroprocaine HCl 是手术治疗中的局部麻醉剂。 |
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S5749 |
ChlorpromazineChlorpromazine (CPZ) 是一种低效的典型抗精神病药,用于治疗精神病如精神分裂症。Chlorpromazine (CPZ) 在体外可抑制 5-HT(2A) receptor 和 dopamine D2。Chlorpromazine (CPZ) 还可抑制 sodium channel,并阻断HERG potassium channels,对应的IC50值为21.6 μM。 |
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S2110 |
VinpocetineVinpocetine (RGH-4405)选择性抑制电压敏感型钠离子通道,用于治疗中风,血管性痴呆和阿尔茨海默症。 |
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S2118 |
Ibutilide FumarateIbutilide Fumarate (U-70226E)是第三类抗心律失常药物,主要用于急性新梗阻的心房颤动(房颤)/心房扑动(房扑),适用于近期发作的房颤或房扑逆转成窦性心律,向内钠电流感应缓慢,这会延长心肌细胞的动作电位和不应期。 |
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S4294 |
Procainamide HClProcainamide HCl是一种sodium channel的阻断剂,也是DNA甲基转移酶抑制剂,用于心律失常的治疗。 |
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S3250New |
VeratrineVeratridine (Cevadine, Cevadin, Cevadene)是一种在百合科植物中发现的甾体生物碱,是 voltage-gated sodium channel 活化剂。Veratridine 会在大鼠中诱发类似焦虑的行为。 |
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S3911 |
VeratramineVeratramine (NSC 17821, NSC 23880), a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. It is a good membrane permeant, undergoes rapid passive diffusion, and has a good stability in the gastrointestinal tract during its absorption. |
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S1828 |
Proparacaine HClProparacaine HCl是电压门控的钠离子通道的拮抗剂,ED50是3.4 mM。 |