Adrenergic Receptor

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抑制剂选择性比较

特异性亚型抑制剂

Adrenergic Receptor产品

所有产品 Adrenergic Receptor抑制剂(12) Adrenergic Receptor拮抗剂(52) Adrenergic Receptor激动剂(60) Adrenergic Receptor化学产品(2) 新Adrenergic Receptor产品

产品目录	产品描述	文献引用	实验数据
S1324	Doxazosin Mesylate Doxazosin Mesylate是一种α-1肾上腺素能受体抑制剂。	J Ocul Pharmacol Ther, 2017, 33(1):50-56 Prostate, 2016, 76(8):757-66 Antiviral Res, 2015, 120:140-6
S5703^New	Carvedilol Phosphate Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.
S5723^New	Carvedilol EP IMpurity E Carvedilol is a nonselective beta blocker/alpha-1 blocker and used in management of congestive heart failure (CHF).
S5739^New	Nebivolol Nebivolol is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.
S4076	Propranolol HCl Propranolol HCl是一种竞争性和非选择性β-肾上腺素受体抑制剂，IC50为12 nM.
S1206	Bisoprolol fumarate Bisoprolol fumarate是一种选择性β1型肾上腺素能受体抑制剂。	J Cell Mol Med, 2018, 22(12):5964-5977 J Toxicol Sci, 2017, 42(6):755-761
S4113	Desvenlafaxine Desvenlafaxine是一种5-羟色胺(5-HT)和去甲肾上腺素(NE)重吸收抑制剂，K_i值分别为40.2 nM和558.4 nM。
S5088	Labetalone hydrochloride Labetalone hydrochloride是labetalone的盐酸盐形式，labetalone是alpha- 和 beta-adrenergic receptors的阻滞剂，被用作一种降压药。
S1642	Methyldopa Methyldopa 是DOPA 脱羧酶竞争性抑制剂，ED50为21.8 mg/kg。
S4112	Desvenlafaxine Succinate Desvenlafaxine Succinate是一种新型5-羟色胺(5-HT)转运蛋白和去甲肾上腺素(NE)转运蛋白重吸收抑制剂，K_i值分别为40.2 nM和558.4 nM
S2086	Ivabradine HCl Ivabradine HCl是一种新型I_f抑制剂，IC50为2.9 μM，特定有效作用于窦房结心脏起搏器活性，是一种纯粹的心跳速率降低剂。	J Pain, 2018, 19(6):626-634
S2113	Cisatracurium Besylate Cisatracurium Besylate是一种非去极化神经肌肉阻断剂，通过抑制神经肌肉的传导而对乙酰胆碱起拮抗作用。
S1283	Asenapine maleate Asenapine maleate是一种高亲和性的包括 serotonin, norepinephrine, dopamine 和 histamine receptors在内的多种受体的拮抗剂，用于治疗神经分裂症以及抑郁狂躁型忧郁症。
S6447^New	Carazolol Carazolol是一种非特异性β肾上腺素能阻滞剂。
S5942^New	Bisoprolol Bisoprolol是心脏选择性β1-adrenergic receptor阻滞剂，用于阻止心肌梗死、心力衰竭、心绞痛和轻中度高血压。
S5782^New	Doxazosin Doxazosin是一种喹唑啉衍生物，可选择性拮抗突触后α1肾上腺素能受体（α1-adrenergic receptors）。
S5923^New	Celiprolol hydrochloride Celiprolol是β1-adrenoceptor拮抗剂，具有部分β2受体激动剂活性。
S5778^New	Esmolol Esmolol是心脏选择性β1阻断剂，能迅速发挥作用、持续时间短，在治疗剂量下，对内在拟交感活性或膜稳定性没有显著影响。
S5780^New	Prazosin Prazosin是α1阻断剂，是alpha-1肾上腺素能受体的反向激动剂。
S5766^New	Alfuzosin Alfuzosin是具有选择性的、竞争性α1肾上腺素能受体（α1-adrenoceptor）拮抗剂。
S5802^New	Alprenolol hydrochloride Alprenolol hydrochloride是alprenolol的盐酸盐形式。Alprenolol是beta adrenergic receptor拮抗剂，被用作抗高血压、减轻心绞痛和抗心律失常的试剂。
S5666^New	Moxisylyte hydrochloride Moxisylyte hydrochloride is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease.
S9285^New	Fargesin Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway.
s9050^New	Boldine Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.
S1409	Alfuzosin HCl Alfuzosin HCl 是一种α1受体拮抗剂，用于治疗良性前列腺增生（BPH）。	Prostate, 2016, 76(8):757-66	PC-3 and LNCaP cell viability following treatment with a1-adrenoceptor antagonists. (A) Cells were treated with drug (0.01-100 μM) for 72 hr and cell viability determined using the resazurin reduction assay. (B) Effect of treatment duration on PC-3 and LNCap cell survival following treatment with doxazosin (30 μM) or prazosin (30 μM). Survival is expressed as the percentage values of untreated vehicle control and values are the mean ( sem) of six independent determinations each conducted in triplicate. P<0.05, **P<0.001 compared to corresponding values for LNCap cells.
S1613	Silodosin Silodosin是一种α1-肾上腺素受体拮抗剂，具有高泌尿选择性。
S1549	Nebivolol HCl 在兔肺β1-肾上腺素受体结合实验中，Nebivolol HCl选择性阻断β1受体，IC50为0.8 nM。
S2691	BMY 7378 Dihydrochloride BMY 7378是一种多靶点抑制剂，作用于α2C-adrenoceptor和α1D-adrenoceptor，pK_i分别为6.54和8.2，且为混合型5-HT1A受体激动剂和拮抗剂，pK_i为8.3。
S1424	Prazosin HCl Prazosin HCl是Quinazoline 衍生物，是一种新型的化学类抗高血压药物。
S2038	Phentolamine Mesylate Phentolamine Mesylate是一种非选择性α-肾上腺素能拮抗剂，IC50为0.1 μM。
S1856	Metoprolol Tartrate Metoprolol Tartrate是一种心脏选择性的β-肾上腺素能受体抑制剂，IC50为42 ng/mL。
S2059	Terazosin HCl Dihydrate Terazosin HCl 是α-肾上腺素能受体抑制剂，用于治疗高血压和前列腺肥大。
S1387	Naftopidil DiHCl Naftopidil DiHCl是一种选择性5-HT1A和α1-adrenergic receptor（α1-肾上腺素受体）拮抗剂，IC50分别为0.1 μM和0.2 μM。
S2517	Maprotiline HCl Maprotiline HCl是一种选择性去甲肾上腺素再摄取抑制剂，也是一种四环类抗抑郁药。
S1831	Carvedilol Carvedilol是一种非选择性β/α-1受体抑制剂，用于治疗充血性心力衰竭和高血压。	Res Pharm Sci, 2015, 10(5):388-96
S2126	Naftopidil Naftopidil 是选择性α1-肾上腺素能受体拮抗剂，或α受体抑制剂，K_i为58.3 nM。
S2499	Phenoxybenzamine HCl Phenoxybenzamine HCl是一种非选择性，不可逆α受体拮抗剂，IC50为550 nM。
S2509	Sotalol HCl Sotalol 是一种非选择性β受体抑制剂，是钾离子通道抑制剂，IC50为43 μM。	Gynecol Oncol, 2018, 151(3):525-532 Toxicol Appl Pharmacol, 2015, 285(1):51-60
S4123	Timolol Maleate Timolol Maleate是一种非选择性的β-肾上腺素能受体拮抗剂，作用于β1/β2，K_i为1.97 nM/2.0 nM。
S4010	Acebutolol HCl Acebutolol HCl是beta-adrenergic receptors（β-肾上腺素能受体）拮抗剂，用于治疗高血压，心绞痛，和心律失常。
S1827	Betaxolol HCl Betaxolol HCl是一种β₁肾上腺素受体阻断剂，IC50是6 Μm。
S2607	Buflomedil HCl Buflomedil HCl是一种血管扩张剂，用于治疗跛行或外周动脉疾病的症状。是一种非选择性alpha adrenergic receptor抑制剂。
S5540	Landiolol hydrochloride Landiolol hydrochloride is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist.
S3664	Flupenthixol dihydrochloride Flupentixol是一种抗精神病安定药物，是D1 and D2多巴胺受体的强效拮抗剂，也是α肾上腺素能受体的拮抗剂。
S4124	Tolazoline HCl Tolazoline HCl是一种非选择性和竞争性的α-肾上腺素能受体拮抗剂。	Insect Biochem Mol Biol, 2017, 90:61-70
S5281	Dapiprazole Hydrochloride Dapiprazole Hydrochloride is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination.
S5337	Rauwolscine hydrochloride Rauwolscine hydrochloride is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM.
S4649	Atipamezole hydrochloride Atipamezole是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。Atipamezole hydrochloride是atipamezole的盐酸盐形式。
S4650	Atipamezole Atipamezole是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。
S3656	Piribedil Piribedil is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.
S1435	Tamsulosin hydrochloride Tamsulosin hydrochloride是一种作用于前列腺的α1A肾上腺素拮抗剂。
S4679	Terazosin HCl Terazosin是一种选择性的alpha-1拮抗剂，用于治疗前列腺肿大症状。它通过抑制膀胱平滑肌和血管壁上的肾上腺素的作用发挥效应。
S4085	Levobetaxolol HCl Levobetaxolol高亲和力作用于克隆的人β1和β2受体，K_i分别为0.76 nM和32.6 nM。
S5042	Bevantolol hydrochloride Bevantolol hydrochloride选择性β肾上腺素受体拮抗剂，没有β内源性拟交感活性，膜稳定性较弱，具有局部麻醉作用。
S8114	ICI-118551 Hydrochloride ICI-118551是高选择性的β2肾上腺素受体拮抗剂，其对β2,β1和β3 受体的Ki值分别为0.7, 49.5和611 nM。
S4100	Esmolol HCl Esmolol是一种心脏选择性B受体阻滞剂，用于控制心跳急或异常心率节律。
S5341	Metroprolol succinate Metoprolol Succinate is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity.
S5432	Dibenamine Hydrochloride Dibenamine is an irreversible blocker of α1 adrenoceptors.
S2091	Betaxolol Betaxolol是一种选择性的β1肾上腺素能受体抑制剂，用于治疗高血压和青光眼。
S4278	Carteolol HCl Carteolol HCl 是一种β-adrenoceptor拮抗剂,用于治疗青光眼。
S5430	Metoprolol Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.
S4817	Atenolol Atenolol是一种选择性的β1 receptor拮抗剂，对人源β1-, β2- 和β3-肾上腺受体的log Kd值分别为−6.66±0.05, −5.99±0.14, −4.11±0.07。
S2373	Yohimbine HCl Yohimbine HCl 是一种瞳孔放大剂，用于治疗阳痿，也是一种春药。
S4291	Labetalol HCl Labetalol HCl是一种选择性alpha1-adrenergic 和非选择性beta-adrenergic receptors的双重拮抗剂，用于高血压的治疗。
S2507	Salbutamol Sulfate Salbutamol Sulfate是一种短效的β2-肾上腺素能受体激动剂，IC50为8.93 µM。	Eur J Immunol, 2016, 1948-58 Sci Rep, 2015, 5:7681	(B) Bar graphs summarize the incidence of VA from Con (An external file that holds a picture, illustration, etc. Object name is srep07681-m1.jpg) and HF (An external file that holds a picture, illustration, etc. Object name is srep07681-m2.jpg) guinea pigs before and after administration of Sal (10 μM) or Sal plus ICI (1 μM) (*p < 0.05, HF + Sal vs. Con + Sal; #p < 0.05, HF + Sal vs. HF + Sal + ICI, n = 6).
S4009	Mirabegron Mirabegron是一种选择性的beta3-adrenoceptor（β3肾上腺素受体）激动剂，EC50为22.4 nM。	Andrologia, 2019, 10.1111/and.13241
S2516	Xylazine HCl Xylazine HCl是一种α2肾上腺素能受体激动剂，用作镇定剂和肌肉松弛剂。	J Neurochem, 2018, 146(6):703-721 Biomed Rep, 2016, 5(3):357-360 Acad Radiol, 2012, 19(3):358-65
S6487^New	fluticasone furoate Fluticasone furoate是一种吸入性皮质类固醇/长效的β肾上腺素能受体激动剂的复方治疗药物，能延长支气管扩张剂的作用时间。它被用于非过敏性和过敏性皮炎的治疗。
S2083^New	Procaterol HCl Procaterol HCl是短效的β2-肾上腺素能受体激动剂，K_p为8 nM，用于治疗哮喘。
S5925^New	Olodaterol hydrochloride Olodaterol hydrochloride是Olodaterol的盐酸盐形式，Olodaterol是一种长效的β2肾上腺素能受体（beta2-adrenergic）激动剂。
S5669^New	Isoxsuprine hydrochloride Isoxsuprine hydrochloride是β-肾上腺素能受体（beta-adrenergic）激动剂，具有血管扩张活性。
S5768^New	Fenoterol hydrobromide Fenoterol hydrobromide是fenoterol的氢溴酸盐。Fenoterol是β2 adrenoreceptor激动剂，具有支气管扩张活性。
S5769^New	Fenoterol Fenoterol是β2 adrenoreceptor激动剂，具有支气管扩张活性。
S5683^New	Isoproterenol sulfate dihydrate Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity.
S5750^New	DL-Norepinephrine hydrochloride Norepinephrine is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors.
S5751^New	Dihydroergotamine Mesylate Dihydroergotamine Mesylate is an ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors.
S9507^New	(−)-Norepinephrine (−)-Norepinephrine是一种天然存在的神经递质和激素。它是adrenergic receptors的激动剂，对α1, α2A和β1肾上腺素受体的Ki值分别为330 nM、56 nM和740 nM。
S9508^New	Brimonidine Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure.
S5564^New	Xylazine Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.
S5727^New	Tetryzoline Tetryzoline is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays.
S5734^New	Midodrine hydrochloride Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor.
S5735^New	Midodrine Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.
S5217^New	Arformoterol Tartrate Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity.
S5654^New	Indacaterol Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.	J Neuroimmunol, 2019, 332:37-48
S3083	Indacaterol Maleate Indacaterol Maleate是一种超长效的β-adrenoceptor激动剂，对β1-adrenoceptor的pK_i为 7.36，对 β2-adrenoceptor 的pK_i为5.48。
S2566	Isoprenaline HCl Isoprenaline是一种非选择性β-肾上腺素能受体激动剂，用于治疗心动过缓和心传导阻滞。
S2020	Formoterol Hemifumarate Formoterol Hemifumarate是一种有效的，选择性的，长效β2-adrenoceptor 激动剂，用于治疗哮喘以及慢性阻塞性肺病。
S2521	Epinephrine bitartrate Epinephrine Bitartrate 是一种α和β-肾上腺素能受体激动剂。
S2458	Clonidine HCl Clonidine HCl 是一种直接起作用的α2肾上腺素能受体激动剂，ED50为0.02±0.01 mg/kg。
S3041	Droxidopa Droxidopa是一种精神药物，是合成的氨基酸前体，它作为神经传导物质去甲肾上腺素和肾上腺素的前药来发挥作用。
S3075	Dexmedetomidine Dexmedetomidine是特护病房和麻醉师使用的一种镇静剂。
S2522	L-Adrenaline L-Adrenaline属于儿茶酚胺类。
S2569	Phenylephrine HCl Phenylephrine HCl是一种选择性的α1-肾上腺素能受体激动剂。	Front Pharmacol, 2019, 10:465 Stem Cells Dev, 2017, 26(7):528-540	(F) Fluo-4 AM-loaded EPLC-SMCs and HCASMCs displayed a change in cell surface area following phenylephrine stimulation. Scale bars, 100 μm. (G) Percentage change in cell surface area. Error bars represent SEM; n = 12 cells; **p < 0.01 versus D15 + 8 + 6 cells that did not exhibit calcium transients, analyzed by the Student's t-test. HCASMCs, human coronary artery smooth muscle cells; NS, no significant difference.
S4065	Guanabenz Acetate Guanabenz Acetate是一种选择性的α2a-肾上腺素能受体， α2b-肾上腺素能受体和α2c-肾上腺素能受体激动剂，pEC50分别为8.25， 7.01和5左右。
S2519	Naphazoline HCl Naphazoline HCl 是一种眼部血管收缩剂，是咪唑啉衍生的拟交感胺类。
S2533	Ritodrine HCl Ritodrine HCl 是Ritodrine的盐酸盐，是β-2肾上腺素能受体激动剂。
S2438	Synephrine HCl Synephrine HCl是一种交感神经α-adrenergic receptor (AR)（肾上腺素受体）激动剂。
S2090	Dexmedetomidine HCl Dexmedetomidine HCl 是一种有效的，高度选择性α-2肾上腺素受体激动剂，具有显著的镇静效果，从而降低患者的麻醉量。
S3061	Epinephrine HCl Epinephrine HCl是一种激素和神经递质。
S3060	Medetomidine HCl Medetomidine HCl是一种选择性的α2-adrenoceptor（α2-肾上腺素受体）激动剂，K_i为1.08 nM，比作用于α1-adrenoceptor选择性高1620倍。	Micromachines, 2018, 9(6)
S1437	Tizanidine HCl Tizanidine HCl是一种α2-肾上腺素受体，抑制中枢神经系统去甲肾上腺素能神经的神经递质的释放。
S2092	Detomidine HCl Detomidine HCl可产生镇静和镇痛作用，这种作用具有剂量依赖性，通过激活α2儿茶酚胺受体来调节。	Nature, 2018, 560(7718):372-376
S5537	Tizanidine
S2545	Scopine Scopine是Anisodine的代谢产物，是一种α1-肾上腺素能受体激动剂，用于治疗急性循环性休克。
S5527	Salmeterol Salmeterol is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).
S4296	Salmeterol Xinafoate Salmeterol Xinafoate是一种长效的β2-adrenergic receptor激动剂，具有抗炎作用，用于哮喘症状和慢性阻塞性肺疾病（COPD）症状的治疗。
S2523	DL-Adrenaline DL-Adrenaline是一种激素，是由肾上腺髓质分泌的一种神经递质。
S4266	Brimonidine Tartrate Brimonidine Tartrate是一种高选择性的α-肾上腺素能受体激动剂，EC50为0.45 nM，用于治疗开角型青光眼或高眼压症。
S3960	Higenamine hydrochloride Higenamine, also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.
S2615	Noradrenaline bitartrate monohydrate Noradrenaline bitartrate monohydrate 是一种直接的α-肾上腺素能受体激动剂。
S7974	L755507 L-755,507是一种有效的、选择性的β3肾上腺素能受体部分激动剂，EC50为0.43 nM。它能在iPSCs和其他细胞类型中增强CRISPR介导的同源重组修复效率。	Hum Mutat, 2019, 10.1002/humu.23848
S4127	Terbutaline Sulfate Terbutaline Sulfate是一种选择性的β2-肾上腺素能受体激动剂，IC50为53 nM。
S4135	Clorprenaline HCl Clorprenaline HCl是β2-受体激动剂，具有显著的扩张支气管作用。
S4043	Tetrahydrozoline HCl Tetrahydrozoline HCl是一种咪唑啉衍生物，具有α受体激动剂活性。
S2576	Xylometazoline HCl Xylometazoline HCl 是α-adrenoceptor激动剂，常用作鼻血管收缩药，高效作用于α_2B肾上腺素受体亚型，EC50为4 μM。
S3640	Methoxyphenamine Hydrochloride Methoxyphenamine Hydrochloride is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.
S3643	Amitraz Amitraz是一种α2 肾上腺素能受体激动剂。它是非系统性杀螨剂和杀虫剂。
S3727	Vilanterol Trifenate Vilanterol trifenatate is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma.	J Neuroimmunol, 2019, 332:37-48
S4693	Guanfacine Hydrochloride Guanfacine Hydrochloride是一种选择性的α2A-肾上腺素受体激动剂，具有降压效果。
S4277	Bambuterol HCl Bambuterol HCl是强效β-adrenoceptor拮抗剂，用于治疗哮喘。
S2362	Synephrine Synephrine是从苦橘及其他柑橘属植物中提取的一种不饱和的植物甾醇，常用于减肥。
S5494	Salbutamol Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases.
S5267	Nylidrin Hydrochloride Nylidrin Hydrochloride, a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well.
S3185	Adrenalone HCl Adrenalone HCl是一种肾上腺素激动剂，作为外用的血管收缩剂和止血剂，主要作用于α-1肾上腺素受体。
S9560^New	Anisodamine Hydrobromide Anisodamine是天然存在的阿托品（atropine）衍生物，具有消炎活性。它能抑制α1-adrenergic receptors和mAChRs。
S4243	Deoxycorticosterone acetate Deoxycorticosterone acetate是一种类固醇激素，用于肌肉注射，是肾上腺皮质类固醇的代替疗法。

产品目录	产品描述	文献引用
S1324	Doxazosin Mesylate Doxazosin Mesylate是一种α-1肾上腺素能受体抑制剂。	J Ocul Pharmacol Ther,2017, 33(1):50-56 Prostate,2016, 76(8):757-66 Antiviral Res,2015, 120:140-6
S5703^New	Carvedilol Phosphate Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.
S5723^New	Carvedilol EP IMpurity E Carvedilol is a nonselective beta blocker/alpha-1 blocker and used in management of congestive heart failure (CHF).
S5739^New	Nebivolol Nebivolol is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.
S4076	Propranolol HCl Propranolol HCl是一种竞争性和非选择性β-肾上腺素受体抑制剂，IC50为12 nM.
S1206	Bisoprolol fumarate Bisoprolol fumarate是一种选择性β1型肾上腺素能受体抑制剂。	J Cell Mol Med,2018, 22(12):5964-5977 J Toxicol Sci,2017, 42(6):755-761
S4113	Desvenlafaxine Desvenlafaxine是一种5-羟色胺(5-HT)和去甲肾上腺素(NE)重吸收抑制剂，K_i值分别为40.2 nM和558.4 nM。
S5088	Labetalone hydrochloride Labetalone hydrochloride是labetalone的盐酸盐形式，labetalone是alpha- 和 beta-adrenergic receptors的阻滞剂，被用作一种降压药。
S1642	Methyldopa Methyldopa 是DOPA 脱羧酶竞争性抑制剂，ED50为21.8 mg/kg。
S4112	Desvenlafaxine Succinate Desvenlafaxine Succinate是一种新型5-羟色胺(5-HT)转运蛋白和去甲肾上腺素(NE)转运蛋白重吸收抑制剂，K_i值分别为40.2 nM和558.4 nM
S2086	Ivabradine HCl Ivabradine HCl是一种新型I_f抑制剂，IC50为2.9 μM，特定有效作用于窦房结心脏起搏器活性，是一种纯粹的心跳速率降低剂。	J Pain,2018, 19(6):626-634
S2113	Cisatracurium Besylate Cisatracurium Besylate是一种非去极化神经肌肉阻断剂，通过抑制神经肌肉的传导而对乙酰胆碱起拮抗作用。

产品目录	产品描述	文献引用	实验数据
S1283	Asenapine maleate Asenapine maleate是一种高亲和性的包括 serotonin, norepinephrine, dopamine 和 histamine receptors在内的多种受体的拮抗剂，用于治疗神经分裂症以及抑郁狂躁型忧郁症。
S6447^New	Carazolol Carazolol是一种非特异性β肾上腺素能阻滞剂。
S5942^New	Bisoprolol Bisoprolol是心脏选择性β1-adrenergic receptor阻滞剂，用于阻止心肌梗死、心力衰竭、心绞痛和轻中度高血压。
S5782^New	Doxazosin Doxazosin是一种喹唑啉衍生物，可选择性拮抗突触后α1肾上腺素能受体（α1-adrenergic receptors）。
S5923^New	Celiprolol hydrochloride Celiprolol是β1-adrenoceptor拮抗剂，具有部分β2受体激动剂活性。
S5778^New	Esmolol Esmolol是心脏选择性β1阻断剂，能迅速发挥作用、持续时间短，在治疗剂量下，对内在拟交感活性或膜稳定性没有显著影响。
S5780^New	Prazosin Prazosin是α1阻断剂，是alpha-1肾上腺素能受体的反向激动剂。
S5766^New	Alfuzosin Alfuzosin是具有选择性的、竞争性α1肾上腺素能受体（α1-adrenoceptor）拮抗剂。
S5802^New	Alprenolol hydrochloride Alprenolol hydrochloride是alprenolol的盐酸盐形式。Alprenolol是beta adrenergic receptor拮抗剂，被用作抗高血压、减轻心绞痛和抗心律失常的试剂。
S5666^New	Moxisylyte hydrochloride Moxisylyte hydrochloride is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease.
S9285^New	Fargesin Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway.
s9050^New	Boldine Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.
S1409	Alfuzosin HCl Alfuzosin HCl 是一种α1受体拮抗剂，用于治疗良性前列腺增生（BPH）。	Prostate, 2016, 76(8):757-66	PC-3 and LNCaP cell viability following treatment with a1-adrenoceptor antagonists. (A) Cells were treated with drug (0.01-100 μM) for 72 hr and cell viability determined using the resazurin reduction assay. (B) Effect of treatment duration on PC-3 and LNCap cell survival following treatment with doxazosin (30 μM) or prazosin (30 μM). Survival is expressed as the percentage values of untreated vehicle control and values are the mean ( sem) of six independent determinations each conducted in triplicate. P<0.05, **P<0.001 compared to corresponding values for LNCap cells.
S1613	Silodosin Silodosin是一种α1-肾上腺素受体拮抗剂，具有高泌尿选择性。
S1549	Nebivolol HCl 在兔肺β1-肾上腺素受体结合实验中，Nebivolol HCl选择性阻断β1受体，IC50为0.8 nM。
S2691	BMY 7378 Dihydrochloride BMY 7378是一种多靶点抑制剂，作用于α2C-adrenoceptor和α1D-adrenoceptor，pK_i分别为6.54和8.2，且为混合型5-HT1A受体激动剂和拮抗剂，pK_i为8.3。
S1424	Prazosin HCl Prazosin HCl是Quinazoline 衍生物，是一种新型的化学类抗高血压药物。
S2038	Phentolamine Mesylate Phentolamine Mesylate是一种非选择性α-肾上腺素能拮抗剂，IC50为0.1 μM。
S1856	Metoprolol Tartrate Metoprolol Tartrate是一种心脏选择性的β-肾上腺素能受体抑制剂，IC50为42 ng/mL。
S2059	Terazosin HCl Dihydrate Terazosin HCl 是α-肾上腺素能受体抑制剂，用于治疗高血压和前列腺肥大。
S1387	Naftopidil DiHCl Naftopidil DiHCl是一种选择性5-HT1A和α1-adrenergic receptor（α1-肾上腺素受体）拮抗剂，IC50分别为0.1 μM和0.2 μM。
S2517	Maprotiline HCl Maprotiline HCl是一种选择性去甲肾上腺素再摄取抑制剂，也是一种四环类抗抑郁药。
S1831	Carvedilol Carvedilol是一种非选择性β/α-1受体抑制剂，用于治疗充血性心力衰竭和高血压。	Res Pharm Sci, 2015, 10(5):388-96
S2126	Naftopidil Naftopidil 是选择性α1-肾上腺素能受体拮抗剂，或α受体抑制剂，K_i为58.3 nM。
S2499	Phenoxybenzamine HCl Phenoxybenzamine HCl是一种非选择性，不可逆α受体拮抗剂，IC50为550 nM。
S2509	Sotalol HCl Sotalol 是一种非选择性β受体抑制剂，是钾离子通道抑制剂，IC50为43 μM。	Gynecol Oncol, 2018, 151(3):525-532 Toxicol Appl Pharmacol, 2015, 285(1):51-60
S4123	Timolol Maleate Timolol Maleate是一种非选择性的β-肾上腺素能受体拮抗剂，作用于β1/β2，K_i为1.97 nM/2.0 nM。
S4010	Acebutolol HCl Acebutolol HCl是beta-adrenergic receptors（β-肾上腺素能受体）拮抗剂，用于治疗高血压，心绞痛，和心律失常。
S1827	Betaxolol HCl Betaxolol HCl是一种β₁肾上腺素受体阻断剂，IC50是6 Μm。
S2607	Buflomedil HCl Buflomedil HCl是一种血管扩张剂，用于治疗跛行或外周动脉疾病的症状。是一种非选择性alpha adrenergic receptor抑制剂。
S5540	Landiolol hydrochloride Landiolol hydrochloride is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist.
S3664	Flupenthixol dihydrochloride Flupentixol是一种抗精神病安定药物，是D1 and D2多巴胺受体的强效拮抗剂，也是α肾上腺素能受体的拮抗剂。
S4124	Tolazoline HCl Tolazoline HCl是一种非选择性和竞争性的α-肾上腺素能受体拮抗剂。	Insect Biochem Mol Biol, 2017, 90:61-70
S5281	Dapiprazole Hydrochloride Dapiprazole Hydrochloride is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination.
S5337	Rauwolscine hydrochloride Rauwolscine hydrochloride is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM.
S4649	Atipamezole hydrochloride Atipamezole是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。Atipamezole hydrochloride是atipamezole的盐酸盐形式。
S4650	Atipamezole Atipamezole是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。
S3656	Piribedil Piribedil is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.
S1435	Tamsulosin hydrochloride Tamsulosin hydrochloride是一种作用于前列腺的α1A肾上腺素拮抗剂。
S4679	Terazosin HCl Terazosin是一种选择性的alpha-1拮抗剂，用于治疗前列腺肿大症状。它通过抑制膀胱平滑肌和血管壁上的肾上腺素的作用发挥效应。
S4085	Levobetaxolol HCl Levobetaxolol高亲和力作用于克隆的人β1和β2受体，K_i分别为0.76 nM和32.6 nM。
S5042	Bevantolol hydrochloride Bevantolol hydrochloride选择性β肾上腺素受体拮抗剂，没有β内源性拟交感活性，膜稳定性较弱，具有局部麻醉作用。
S8114	ICI-118551 Hydrochloride ICI-118551是高选择性的β2肾上腺素受体拮抗剂，其对β2,β1和β3 受体的Ki值分别为0.7, 49.5和611 nM。
S4100	Esmolol HCl Esmolol是一种心脏选择性B受体阻滞剂，用于控制心跳急或异常心率节律。
S5341	Metroprolol succinate Metoprolol Succinate is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity.
S5432	Dibenamine Hydrochloride Dibenamine is an irreversible blocker of α1 adrenoceptors.
S2091	Betaxolol Betaxolol是一种选择性的β1肾上腺素能受体抑制剂，用于治疗高血压和青光眼。
S4278	Carteolol HCl Carteolol HCl 是一种β-adrenoceptor拮抗剂,用于治疗青光眼。
S5430	Metoprolol Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.
S4817	Atenolol Atenolol是一种选择性的β1 receptor拮抗剂，对人源β1-, β2- 和β3-肾上腺受体的log Kd值分别为−6.66±0.05, −5.99±0.14, −4.11±0.07。
S2373	Yohimbine HCl Yohimbine HCl 是一种瞳孔放大剂，用于治疗阳痿，也是一种春药。
S4291	Labetalol HCl Labetalol HCl是一种选择性alpha1-adrenergic 和非选择性beta-adrenergic receptors的双重拮抗剂，用于高血压的治疗。

产品目录	产品描述	文献引用	实验数据
S2507	Salbutamol Sulfate Salbutamol Sulfate是一种短效的β2-肾上腺素能受体激动剂，IC50为8.93 µM。	Eur J Immunol, 2016, 1948-58 Sci Rep, 2015, 5:7681	(B) Bar graphs summarize the incidence of VA from Con (An external file that holds a picture, illustration, etc. Object name is srep07681-m1.jpg) and HF (An external file that holds a picture, illustration, etc. Object name is srep07681-m2.jpg) guinea pigs before and after administration of Sal (10 μM) or Sal plus ICI (1 μM) (*p < 0.05, HF + Sal vs. Con + Sal; #p < 0.05, HF + Sal vs. HF + Sal + ICI, n = 6).
S4009	Mirabegron Mirabegron是一种选择性的beta3-adrenoceptor（β3肾上腺素受体）激动剂，EC50为22.4 nM。	Andrologia, 2019, 10.1111/and.13241
S2516	Xylazine HCl Xylazine HCl是一种α2肾上腺素能受体激动剂，用作镇定剂和肌肉松弛剂。	J Neurochem, 2018, 146(6):703-721 Biomed Rep, 2016, 5(3):357-360 Acad Radiol, 2012, 19(3):358-65
S6487^New	fluticasone furoate Fluticasone furoate是一种吸入性皮质类固醇/长效的β肾上腺素能受体激动剂的复方治疗药物，能延长支气管扩张剂的作用时间。它被用于非过敏性和过敏性皮炎的治疗。
S2083^New	Procaterol HCl Procaterol HCl是短效的β2-肾上腺素能受体激动剂，K_p为8 nM，用于治疗哮喘。
S5925^New	Olodaterol hydrochloride Olodaterol hydrochloride是Olodaterol的盐酸盐形式，Olodaterol是一种长效的β2肾上腺素能受体（beta2-adrenergic）激动剂。
S5669^New	Isoxsuprine hydrochloride Isoxsuprine hydrochloride是β-肾上腺素能受体（beta-adrenergic）激动剂，具有血管扩张活性。
S5768^New	Fenoterol hydrobromide Fenoterol hydrobromide是fenoterol的氢溴酸盐。Fenoterol是β2 adrenoreceptor激动剂，具有支气管扩张活性。
S5769^New	Fenoterol Fenoterol是β2 adrenoreceptor激动剂，具有支气管扩张活性。
S5683^New	Isoproterenol sulfate dihydrate Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity.
S5750^New	DL-Norepinephrine hydrochloride Norepinephrine is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors.
S5751^New	Dihydroergotamine Mesylate Dihydroergotamine Mesylate is an ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors.
S9507^New	(−)-Norepinephrine (−)-Norepinephrine是一种天然存在的神经递质和激素。它是adrenergic receptors的激动剂，对α1, α2A和β1肾上腺素受体的Ki值分别为330 nM、56 nM和740 nM。
S9508^New	Brimonidine Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure.
S5564^New	Xylazine Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.
S5727^New	Tetryzoline Tetryzoline is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays.
S5734^New	Midodrine hydrochloride Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor.
S5735^New	Midodrine Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.
S5217^New	Arformoterol Tartrate Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity.
S5654^New	Indacaterol Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.	J Neuroimmunol, 2019, 332:37-48
S3083	Indacaterol Maleate Indacaterol Maleate是一种超长效的β-adrenoceptor激动剂，对β1-adrenoceptor的pK_i为 7.36，对 β2-adrenoceptor 的pK_i为5.48。
S2566	Isoprenaline HCl Isoprenaline是一种非选择性β-肾上腺素能受体激动剂，用于治疗心动过缓和心传导阻滞。
S2020	Formoterol Hemifumarate Formoterol Hemifumarate是一种有效的，选择性的，长效β2-adrenoceptor 激动剂，用于治疗哮喘以及慢性阻塞性肺病。
S2521	Epinephrine bitartrate Epinephrine Bitartrate 是一种α和β-肾上腺素能受体激动剂。
S2458	Clonidine HCl Clonidine HCl 是一种直接起作用的α2肾上腺素能受体激动剂，ED50为0.02±0.01 mg/kg。
S3041	Droxidopa Droxidopa是一种精神药物，是合成的氨基酸前体，它作为神经传导物质去甲肾上腺素和肾上腺素的前药来发挥作用。
S3075	Dexmedetomidine Dexmedetomidine是特护病房和麻醉师使用的一种镇静剂。
S2522	L-Adrenaline L-Adrenaline属于儿茶酚胺类。
S2569	Phenylephrine HCl Phenylephrine HCl是一种选择性的α1-肾上腺素能受体激动剂。	Front Pharmacol, 2019, 10:465 Stem Cells Dev, 2017, 26(7):528-540	(F) Fluo-4 AM-loaded EPLC-SMCs and HCASMCs displayed a change in cell surface area following phenylephrine stimulation. Scale bars, 100 μm. (G) Percentage change in cell surface area. Error bars represent SEM; n = 12 cells; **p < 0.01 versus D15 + 8 + 6 cells that did not exhibit calcium transients, analyzed by the Student's t-test. HCASMCs, human coronary artery smooth muscle cells; NS, no significant difference.
S4065	Guanabenz Acetate Guanabenz Acetate是一种选择性的α2a-肾上腺素能受体， α2b-肾上腺素能受体和α2c-肾上腺素能受体激动剂，pEC50分别为8.25， 7.01和5左右。
S2519	Naphazoline HCl Naphazoline HCl 是一种眼部血管收缩剂，是咪唑啉衍生的拟交感胺类。
S2533	Ritodrine HCl Ritodrine HCl 是Ritodrine的盐酸盐，是β-2肾上腺素能受体激动剂。
S2438	Synephrine HCl Synephrine HCl是一种交感神经α-adrenergic receptor (AR)（肾上腺素受体）激动剂。
S2090	Dexmedetomidine HCl Dexmedetomidine HCl 是一种有效的，高度选择性α-2肾上腺素受体激动剂，具有显著的镇静效果，从而降低患者的麻醉量。
S3061	Epinephrine HCl Epinephrine HCl是一种激素和神经递质。
S3060	Medetomidine HCl Medetomidine HCl是一种选择性的α2-adrenoceptor（α2-肾上腺素受体）激动剂，K_i为1.08 nM，比作用于α1-adrenoceptor选择性高1620倍。	Micromachines, 2018, 9(6)
S1437	Tizanidine HCl Tizanidine HCl是一种α2-肾上腺素受体，抑制中枢神经系统去甲肾上腺素能神经的神经递质的释放。
S2092	Detomidine HCl Detomidine HCl可产生镇静和镇痛作用，这种作用具有剂量依赖性，通过激活α2儿茶酚胺受体来调节。	Nature, 2018, 560(7718):372-376
S5537	Tizanidine
S2545	Scopine Scopine是Anisodine的代谢产物，是一种α1-肾上腺素能受体激动剂，用于治疗急性循环性休克。
S5527	Salmeterol Salmeterol is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).
S4296	Salmeterol Xinafoate Salmeterol Xinafoate是一种长效的β2-adrenergic receptor激动剂，具有抗炎作用，用于哮喘症状和慢性阻塞性肺疾病（COPD）症状的治疗。
S2523	DL-Adrenaline DL-Adrenaline是一种激素，是由肾上腺髓质分泌的一种神经递质。
S4266	Brimonidine Tartrate Brimonidine Tartrate是一种高选择性的α-肾上腺素能受体激动剂，EC50为0.45 nM，用于治疗开角型青光眼或高眼压症。
S3960	Higenamine hydrochloride Higenamine, also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.
S2615	Noradrenaline bitartrate monohydrate Noradrenaline bitartrate monohydrate 是一种直接的α-肾上腺素能受体激动剂。
S7974	L755507 L-755,507是一种有效的、选择性的β3肾上腺素能受体部分激动剂，EC50为0.43 nM。它能在iPSCs和其他细胞类型中增强CRISPR介导的同源重组修复效率。	Hum Mutat, 2019, 10.1002/humu.23848
S4127	Terbutaline Sulfate Terbutaline Sulfate是一种选择性的β2-肾上腺素能受体激动剂，IC50为53 nM。
S4135	Clorprenaline HCl Clorprenaline HCl是β2-受体激动剂，具有显著的扩张支气管作用。
S4043	Tetrahydrozoline HCl Tetrahydrozoline HCl是一种咪唑啉衍生物，具有α受体激动剂活性。
S2576	Xylometazoline HCl Xylometazoline HCl 是α-adrenoceptor激动剂，常用作鼻血管收缩药，高效作用于α_2B肾上腺素受体亚型，EC50为4 μM。
S3640	Methoxyphenamine Hydrochloride Methoxyphenamine Hydrochloride is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.
S3643	Amitraz Amitraz是一种α2 肾上腺素能受体激动剂。它是非系统性杀螨剂和杀虫剂。
S3727	Vilanterol Trifenate Vilanterol trifenatate is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma.	J Neuroimmunol, 2019, 332:37-48
S4693	Guanfacine Hydrochloride Guanfacine Hydrochloride是一种选择性的α2A-肾上腺素受体激动剂，具有降压效果。
S4277	Bambuterol HCl Bambuterol HCl是强效β-adrenoceptor拮抗剂，用于治疗哮喘。
S2362	Synephrine Synephrine是从苦橘及其他柑橘属植物中提取的一种不饱和的植物甾醇，常用于减肥。
S5494	Salbutamol Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases.
S5267	Nylidrin Hydrochloride Nylidrin Hydrochloride, a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well.
S3185	Adrenalone HCl Adrenalone HCl是一种肾上腺素激动剂，作为外用的血管收缩剂和止血剂，主要作用于α-1肾上腺素受体。

产品目录	产品描述	文献引用	实验数据
S9560^New	Anisodamine Hydrobromide Anisodamine是天然存在的阿托品（atropine）衍生物，具有消炎活性。它能抑制α1-adrenergic receptors和mAChRs。
S4243	Deoxycorticosterone acetate Deoxycorticosterone acetate是一种类固醇激素，用于肌肉注射，是肾上腺皮质类固醇的代替疗法。

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S9560^New