Adrenergic Receptor
Adrenergic Receptor产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S1324 |
Doxazosin MesylateDoxazosin Mesylate是一种α-1肾上腺素能受体抑制剂。 |
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S6345New |
3-Nitro-L-tyrosine3-Nitro-L-tyrosine (3-NT, N-Tyr, MNT) 是由过氧化亚硝酸盐从L-酪氨酸合成的,是一氧化氮和超氧化物的产物。3-Nitro-L-tyrosine 可通过抑制 alpha 1-adrenoceptor 介导的反应来抑制血管紧张素II引起的血液动力学反应。 |
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S4076 |
Propranolol HClPropranolol HCl (AY-64043, ICI-45520, NCS-91523) 是一种竞争性和非选择性β-肾上腺素受体抑制剂,IC50为12 nM. |
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S1206 |
Bisoprolol fumarateBisoprolol fumarate (EMD33512) 是一种选择性β1型肾上腺素能受体抑制剂。 |
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S4113 |
DesvenlafaxineDesvenlafaxine (WY 45233 Succinate)是一种5-羟色胺(5-HT)和去甲肾上腺素(NE)重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM。 |
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S5739 |
NebivololNebivolol (Bystolic) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure. |
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S5088 |
Labetalone hydrochlorideLabetalone hydrochloride (Benzoic amide)是labetalone的盐酸盐形式,labetalone是alpha- 和 beta-adrenergic receptors的阻滞剂,被用作一种降压药。 |
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S5703 |
Carvedilol PhosphateCarvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity. |
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S1642 |
MethyldopaMethyldopa 是DOPA 脱羧酶竞争性抑制剂,ED50为21.8 mg/kg。 |
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S5787 |
DronedaroneDronedarone (SR33589)是amiodarone的衍生物,是III类抗心律失常药。它能抑制与心率相关的快速Na+流、抑制α和β肾上腺素能受体、阻断K+外向离子流和Ca2+慢速内流。 |
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S4112 |
Desvenlafaxine SuccinateDesvenlafaxine Succinate (WY 45233) 是一种新型5-羟色胺(5-HT)转运蛋白 和去甲肾上腺素(NE)转运蛋白重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM |
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S2086 |
Ivabradine HClIvabradine HCl (S 16257-2)是一种新型If抑制剂,IC50为2.9 μM,特定有效作用于窦房结心脏起搏器活性,是一种纯粹的心跳速率降低剂。 |
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S9560 |
Anisodamine HydrobromideAnisodamine (6-Hydroxyhyoscyamine)是天然存在的阿托品(atropine)衍生物,具有消炎活性。它能抑制α1-adrenergic receptors和mAChRs。 |
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S2113 |
Cisatracurium BesylateCisatracurium Besylate是一种非去极化神经肌肉阻断剂,通过抑制神经肌肉的传导而对乙酰胆碱起拮抗作用。 |
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S5723 |
Carvedilol EP IMpurity ECarvedilol EP IMpurity E (Carvedilol USP E, Carvedilol Impurity E) is a nonselective beta blocker/alpha-1 blocker and used in management of congestive heart failure (CHF). |
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S3764 |
Isoferulic AcidIsoferulic acid (Hesperetic acid, Hesperetate, Isoferulate), a major active ingredient of Cimicifuga heracleifolia, shows anti-inflammatory, antiviral, antioxidant, and antidiabetic properties. |
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S1283 |
Asenapine maleateAsenapine maleate (Org 5222)是一种高亲和性的包括 serotonin, norepinephrine, dopamine 和 histamine receptors在内的多种受体的拮抗剂,用于治疗神经分裂症以及抑郁狂躁型忧郁症。 |
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S0812New |
SR59230ASR59230A 是一种血脑屏障穿透性的、有效的 β3-adrenergic receptor 的选择性拮抗剂,对β3、β1和β2受体的IC50分别为40 nM、408 nM和648 nM。 |
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S0116New |
Piperoxan hydrochloridePiperoxan hydrochloride (Benodaine, Fourneau 933, F933, DL-Piperoxan) 是 α2 (alpha 2) adrenoceptor 的拮抗剂。 |
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S1409 |
Alfuzosin HClAlfuzosin HCl 是一种α1受体拮抗剂,用于治疗良性前列腺增生(BPH)。 |
![]() ![]() PC-3 and LNCaP cell viability following treatment with a1-adrenoceptor antagonists. (A) Cells were treated with drug (0.01-100 μM) for 72 hr and cell viability determined using the resazurin reduction assay. (B) Effect of treatment duration on PC-3 and LNCap cell survival following treatment with doxazosin (30 μM) or prazosin (30 μM). Survival is expressed as the percentage values of untreated vehicle control and values are the mean ( sem) of six independent determinations each conducted in triplicate. *P<0.05, ***P<0.001 compared to corresponding values for LNCap cells.
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S1613 |
SilodosinSilodosin (KAD 3213, KMD 3213)是一种α1-肾上腺素受体拮抗剂,具有高泌尿选择性。 |
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S1549 |
Nebivolol HCl在兔肺β1-肾上腺素受体结合实验中,Nebivolol HCl (R-65824)选择性阻断β1受体,IC50为0.8 nM。 |
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S2691 |
BMY 7378 DihydrochlorideBMY 7378是一种多靶点抑制剂,作用于α2C-adrenoceptor和α1D-adrenoceptor,pKi分别为6.54和8.2,且为混合型5-HT1A受体激动剂和拮抗剂,pKi为8.3。 |
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S1424 |
Prazosin HClPrazosin HCl (cp-12299-1) 是Quinazoline 衍生物,是一种新型的化学类抗高血压药物。 |
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S2038 |
Phentolamine MesylatePhentolamine Mesylate是一种非选择性α-肾上腺素能拮抗剂,IC50为0.1 μM。 |
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S1856 |
Metoprolol TartrateMetoprolol Tartrate (CGP 2175E) 是一种心脏选择性的β-肾上腺素能受体抑制剂,IC50为42 ng/mL。 |
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S2059 |
Terazosin HCl DihydrateTerazosin HCl 是α-肾上腺素能受体抑制剂,用于治疗高血压和前列腺肥大。 |
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S1387 |
Naftopidil DiHClNaftopidil DiHCl (KT-611)是一种选择性5-HT1A和α1-adrenergic receptor(α1-肾上腺素受体)拮抗剂,IC50分别为0.1 μM和0.2 μM。 |
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S2517 |
Maprotiline HClMaprotiline HCl是一种选择性去甲肾上腺素再摄取抑制剂,也是一种四环类抗抑郁药。 |
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S1831 |
CarvedilolCarvedilol (BM-14190, SKF 105517)是一种非选择性β/α-1受体抑制剂,用于治疗充血性心力衰竭和高血压。 |
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S2126 |
NaftopidilNaftopidil (KT-611) 是选择性α1-肾上腺素能受体拮抗剂,或α受体抑制剂,Ki为58.3 nM。 |
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S2499 |
Phenoxybenzamine HClPhenoxybenzamine HCl (NSC 37448, NCI-c01661)是一种非选择性,不可逆α受体拮抗剂,IC50为550 nM。 |
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S2509 |
Sotalol HClSotalol 是一种非选择性β受体抑制剂,是钾离子通道抑制剂,IC50为43 μM。 |
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S4123 |
Timolol MaleateTimolol Maleate (MK-950)是一种非选择性的β-肾上腺素能受体拮抗剂,作用于β1/β2,Ki为1.97 nM/2.0 nM。 |
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S4010 |
Acebutolol HClAcebutolol HCl是beta-adrenergic receptors(β-肾上腺素能受体)拮抗剂,用于治疗高血压,心绞痛,和心律失常。 |
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S1827 |
Betaxolol HClBetaxolol (SL 75212)是一种β1肾上腺素受体阻断剂,IC50是6 Μm。 |
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S2607 |
Buflomedil HClBuflomedil HCl是一种血管扩张剂,用于治疗跛行或外周动脉疾病的症状。是一种非选择性alpha adrenergic receptor抑制剂。 |
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S5540 |
Landiolol hydrochlorideLandiolol hydrochloride (ONO-1101) is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist. |
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S3664 |
Flupentixol dihydrochlorideFlupentixol (Flupenthixol) dihydrochloride 是一种抗精神病安定药物,是D1 and D2多巴胺受体的强效拮抗剂,也是α肾上腺素能受体的拮抗剂。 |
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S5802 |
Alprenolol hydrochlorideAlprenolol hydrochloride是alprenolol的盐酸盐形式。Alprenolol是beta adrenergic receptor拮抗剂,被用作抗高血压、减轻心绞痛和抗心律失常的试剂。 |
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S4124 |
Tolazoline HClTolazoline HCl是一种非选择性和竞争性的α-肾上腺素能受体拮抗剂。 |
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S5666 |
Moxisylyte hydrochlorideMoxisylyte hydrochloride (thymoxamine) is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease. |
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S5942 |
BisoprololBisoprolol是心脏选择性β1-adrenergic receptor阻滞剂,用于阻止心肌梗死、心力衰竭、心绞痛和轻中度高血压。 |
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S5766 |
AlfuzosinAlfuzosin是具有选择性的、竞争性α1肾上腺素能受体(α1-adrenoceptor)拮抗剂。 |
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S9285 |
FargesinFargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway. |
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S5281 |
Dapiprazole HydrochlorideDapiprazole Hydrochloride (Glamidolo Hydrochloride, Reversil Hydrochloride) is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination. |
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S5337 |
Rauwolscine hydrochlorideRauwolscine hydrochloride (Isoyohimbine, α-Yohimbine, corynanthidine) is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM. |
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S4649 |
Atipamezole hydrochlorideAtipamezole (Antisedan, MPV1248) 是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。Atipamezole hydrochloride是atipamezole的盐酸盐形式。 |
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S4650 |
AtipamezoleAtipamezole (MPV-1248, MPV1248, Antisedan)是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。 |
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S3656 |
PiribedilPiribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties. |
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S9050 |
BoldineBoldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects. |
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S1435 |
Tamsulosin hydrochlorideTamsulosin (Flomax) hydrochloride是一种作用于前列腺的α1A肾上腺素拮抗剂。 |
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S4679 |
Terazosin HClTerazosin (Hytrin, Zayasel, Terazosine, Flumarc, Fosfomic, Blavin)是一种选择性的alpha-1拮抗剂,用于治疗前列腺肿大症状。它通过抑制膀胱平滑肌和血管壁上的肾上腺素的作用发挥效应。 |
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S5780 |
PrazosinPrazosin是α1阻断剂,是alpha-1肾上腺素能受体的反向激动剂。 |
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S4085 |
Levobetaxolol HClLevobetaxolol (AL 1577A)高亲和力作用于克隆的人β1和β2受体,Ki分别为0.76 nM和32.6 nM。 |
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S5042 |
Bevantolol hydrochlorideBevantolol hydrochloride (NC-1400) 选择性β肾上腺素受体拮抗剂,没有β内源性拟交感活性,膜稳定性较弱,具有局部麻醉作用。 |
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S5778 |
EsmololEsmolol是心脏选择性β1阻断剂,能迅速发挥作用、持续时间短,在治疗剂量下,对内在拟交感活性或膜稳定性没有显著影响。 |
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S8114 |
ICI-118551 HydrochlorideICI-118551是高选择性的β2肾上腺素受体拮抗剂,其对β2,β1和β3 受体的Ki值分别为0.7, 49.5和611 nM。 |
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S4100 |
Esmolol HClEsmolol (ASL8052) 是一种心脏选择性B受体阻滞剂,用于控制心跳急或异常心率节律。 |
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S5782 |
DoxazosinDoxazosin是一种喹唑啉衍生物,可选择性拮抗突触后α1肾上腺素能受体(α1-adrenergic receptors)。 |
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S5923 |
Celiprolol hydrochlorideCeliprolol是β1-adrenoceptor拮抗剂,具有部分β2受体激动剂活性。 |
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S6447 |
CarazololCarazolol是一种非特异性β肾上腺素能阻滞剂。 |
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S5023 |
NadololNadolol (Corgard, Solgol, Anabet, SQ11725) 是一种非选择性的β-肾上腺素能受体拮抗剂,具有抗高血压和抗心律失常活性。 |
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S5341 |
Metroprolol succinateMetoprolol Succinate (Metoprolol succinate) is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. |
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S5432 |
Dibenamine HydrochlorideDibenamine (N-(2-Chloroethyl)dibenzylamine, Sympatholytin, Dibenzylchlorethamine) is an irreversible blocker of α1 adrenoceptors. |
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S2091 |
BetaxololBetaxolol (SL 75212) 是一种选择性的β1肾上腺素能受体抑制剂,用于治疗高血压和青光眼。 |
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S4278 |
Carteolol HClCarteolol HCl 是一种β-adrenoceptor拮抗剂,用于治疗青光眼。 |
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S5430 |
MetoprololMetoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension. |
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S4817 |
AtenololAtenolol (Tenormin, Normiten, Blokium)是一种选择性的β1 receptor拮抗剂,对人源β1-, β2- 和β3-肾上腺受体的log Kd值分别为−6.66±0.05, −5.99±0.14, −4.11±0.07。 |
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S2373 |
Yohimbine HClYohimbine (Antagonil) 是一种瞳孔放大剂,用于治疗阳痿,也是一种春药。 |
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S4291 |
Labetalol HClLabetalol HCl是一种选择性alpha1-adrenergic 和非选择性beta-adrenergic receptors的双重拮抗剂,用于高血压的治疗。 |
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S4797 |
NicergolineNicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has a selective alpha-1A adrenergic receptor blocking property and also other additional mechanisms of actions. |
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S2507 |
Salbutamol SulfateSalbutamol Sulfate (Albuterol) 是一种短效的β2-肾上腺素能受体激动剂,IC50为8.93 µM。 |
![]() ![]() (B) Bar graphs summarize the incidence of VA from Con (An external file that holds a picture, illustration, etc. Object name is srep07681-m1.jpg) and HF (An external file that holds a picture, illustration, etc. Object name is srep07681-m2.jpg) guinea pigs before and after administration of Sal (10 μM) or Sal plus ICI (1 μM) (*p < 0.05, HF + Sal vs. Con + Sal; #p < 0.05, HF + Sal vs. HF + Sal + ICI, n = 6).
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S4009 |
MirabegronMirabegron (YM 178)是一种选择性的beta3-adrenoceptor(β3肾上腺素受体)激动剂,EC50为22.4 nM。 |
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S2516 |
Xylazine HClXylazine HCl是一种α2肾上腺素能受体激动剂,用作镇定剂和肌肉松弛剂。 |
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S3294New |
Demethyl-CoclaurineDemethyl-Coclaurine (Higenamine, Norcoclaurine) 是中草药乌头根的关键成分,是一种 beta-2 adrenergic receptor (β2-AR) 的激动剂。Demethyl-Coclaurine 可刺激 AKT 的磷酸化,需要 PI3K 的激活才能使心肌细胞产生抗凋亡的作用。 |
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S3083 |
Indacaterol MaleateIndacaterol (QAB149)是一种超长效的β-adrenoceptor激动剂,对β1-adrenoceptor的pKi为 7.36,对 β2-adrenoceptor 的pKi为5.48。 |
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S2566 |
Isoprenaline HClIsoprenaline (NCI-c55630) 是一种非选择性β-肾上腺素能受体激动剂,用于治疗心动过缓和心传导阻滞。 |
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S2020 |
Formoterol HemifumarateFormoterol Hemifumarate (Eformoterol, CGP 25827A, NSC 299587, YM 08316)是一种有效的,选择性的,长效β2-adrenoceptor 激动剂,用于治疗哮喘以及慢性阻塞性肺病。 |
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S2521 |
Epinephrine bitartrateEpinephrine bitartrate (Adrenalinium)是一种α和β-肾上腺素能受体激动剂。 |
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S2458 |
Clonidine HClClonidine HCl 是一种直接起作用的α2肾上腺素能受体激动剂,ED50为0.02±0.01 mg/kg。 |
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S3041 |
DroxidopaDroxidopa (L-DOPS)是一种精神药物,是合成的氨基酸前体,它作为神经传导物质去甲肾上腺素和肾上腺素的前药来发挥作用。 |
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S3075 |
DexmedetomidineDexmedetomidine是特护病房和麻醉师使用的一种镇静剂。 |
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S2522 |
L-AdrenalineL-Adrenaline (Epinephrine) 属于儿茶酚胺类。 |
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S2569 |
Phenylephrine HClPhenylephrine HCl (NCI-c55641)是一种选择性的α1-肾上腺素能受体激动剂。 |
![]() ![]() (F) Fluo-4 AM-loaded EPLC-SMCs and HCASMCs displayed a change in cell surface area following phenylephrine stimulation. Scale bars, 100 μm. (G) Percentage change in cell surface area. Error bars represent SEM; n = 12 cells; **p < 0.01 versus D15 + 8 + 6 cells that did not exhibit calcium transients, analyzed by the Student's t-test. HCASMCs, human coronary artery smooth muscle cells; NS, no significant difference.
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S4065 |
Guanabenz AcetateGuanabenz Acetate (WY-8678) 是一种选择性的α2a-肾上腺素能受体, α2b-肾上腺素能受体和α2c-肾上腺素能受体激动剂,pEC50分别为8.25, 7.01和5左右。 |
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S2519 |
Naphazoline HClNaphazoline HCl 是一种眼部血管收缩剂,是咪唑啉衍生的拟交感胺类。 |
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S2533 |
Ritodrine HClRitodrine HCl (NSC 291565) 是Ritodrine的盐酸盐,是β-2肾上腺素能受体激动剂。 |
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S2438 |
Synephrine HClSynephrine HCl是一种交感神经α-adrenergic receptor (AR)(肾上腺素受体)激动剂。 |
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S2090 |
Dexmedetomidine HClDexmedetomidine HCl 是一种有效的,高度选择性α-2肾上腺素受体激动剂,具有显著的镇静效果,从而降低患者的麻醉量。 |
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S3061 |
Epinephrine HClEpinephrine HCl (Adrenaline) 是一种激素和神经递质。 |
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S3060 |
Medetomidine HClMedetomidine HCl是一种选择性的α2-adrenoceptor(α2-肾上腺素受体)激动剂,Ki为1.08 nM,比作用于α1-adrenoceptor选择性高1620倍。 |
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S1437 |
Tizanidine HClTizanidine HCl (DS 103-282)是一种α2-肾上腺素受体,抑制中枢神经系统去甲肾上腺素能神经的神经递质的释放。 |
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S2092 |
Detomidine HClDetomidine HCl可产生镇静和镇痛作用,这种作用具有剂量依赖性,通过激活α2儿茶酚胺受体来调节。 |
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S5537 |
TizanidineTizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity. |
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S2545 |
ScopineScopine是Anisodine的代谢产物,是一种α1-肾上腺素能受体激动剂,用于治疗急性循环性休克。 |
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S5527 |
SalmeterolSalmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500). |
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S4296 |
Salmeterol XinafoateSalmeterol Xinafoate是一种长效的β2-adrenergic receptor激动剂,具有抗炎作用,用于哮喘症状和慢性阻塞性肺疾病(COPD)症状的治疗。 |
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S2523 |
DL-AdrenalineDL-Adrenaline是一种激素,是由肾上腺髓质分泌的一种神经递质。 |
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S4266 |
Brimonidine TartrateBrimonidine Tartrate是一种高选择性的α-肾上腺素能受体激动剂,EC50为0.45 nM,用于治疗开角型青光眼或高眼压症。 |
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S3960 |
Higenamine hydrochlorideHigenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants. |
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S2615 |
Noradrenaline bitartrate monohydrateNoradrenaline bitartrate monohydrate (Levophed)是一种直接的α-肾上腺素能受体激动剂。 |
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S5768 |
Fenoterol hydrobromideFenoterol hydrobromide (Phenoterol)是fenoterol的氢溴酸盐。Fenoterol是β2 adrenoreceptor激动剂,具有支气管扩张活性。 |
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S7974 |
L755507L-755,507是一种有效的、选择性的β3肾上腺素能受体部分激动剂,EC50为0.43 nM。它能在iPSCs和其他细胞类型中增强CRISPR介导的同源重组修复效率。 |
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S5564 |
XylazineXylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. |
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S4127 |
Terbutaline SulfateTerbutaline Sulfate是一种选择性的β2-肾上腺素能受体激动剂,IC50为53 nM。 |
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S5769 |
FenoterolFenoterol (Phenoterol) 是β2 adrenoreceptor激动剂,具有支气管扩张活性。 |
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S5683 |
Isoproterenol sulfate dihydrateIsoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity. |
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S4135 |
Clorprenaline HClClorprenaline HCl (NSC 334693) 是β2-受体激动剂,具有显著的扩张支气管作用。 |
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S4043 |
Tetrahydrozoline HClTetrahydrozoline (Tetryzoline) HCl是一种咪唑啉衍生物,具有α受体激动剂活性。 |
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S5217 |
Arformoterol TartrateArformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity. |
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S5734 |
Midodrine hydrochlorideMidodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor. |
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S5735 |
MidodrineMidodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist. |
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S5727 |
TetryzolineTetryzoline (Tetrahydrozoline) is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays. |
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S2576 |
Xylometazoline HClXylometazoline HCl 是α-adrenoceptor激动剂,常用作鼻血管收缩药,高效作用于α2B肾上腺素受体亚型,EC50为4 μM。 |
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S3640 |
Methoxyphenamine HydrochlorideMethoxyphenamine Hydrochloride (2-methoxy-N-methylamphetamine, OMMA) is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator. |
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S3643 |
AmitrazAmitraz (NSC 324552) 是一种α2 肾上腺素能受体激动剂。它是非系统性杀螨剂和杀虫剂。 |
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S2304 |
GramineGramine (Donaxine) 是一种从巨型芦苇中分离出的天然吲哚生物碱,是一种活性脂联素受体(AdipoR)激动剂,对AdipoR2和AdipoR1的IC50分别为3.2 µM和4.2 µM。 禾胺也是人和小鼠 β2-Adrenergic receptor (β2-AR) 激动剂。 |
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S3727 |
Vilanterol TrifenateVilanterol trifenatate (GW642444M) is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma. |
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S6583 |
Apraclonidine HClApraclonidine (Iopidine)是一种拟交感神经要,用于治疗青光眼。它是α2-肾上腺素能受体激动剂。 |
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S4693 |
Guanfacine HydrochlorideGuanfacine Hydrochloride (Tenex, Intuniv)是一种选择性的α2A-肾上腺素受体激动剂,具有降压效果。 |
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S5669 |
Isoxsuprine hydrochlorideIsoxsuprine hydrochloride是β-肾上腺素能受体(beta-adrenergic)激动剂,具有血管扩张活性。 |
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S5654 |
IndacaterolIndacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor. |
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S5925 |
Olodaterol hydrochlorideOlodaterol hydrochloride (BI-1744)是Olodaterol的盐酸盐形式,Olodaterol是一种长效的β2肾上腺素能受体(beta2-adrenergic)激动剂。 |
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S2083 |
Procaterol HClProcaterol HCl (OPC-2009) 是短效的β2-肾上腺素能受体激动剂,Kp为8 nM,用于治疗哮喘。 |
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S4277 |
Bambuterol HClBambuterol HCl是强效β-adrenoceptor拮抗剂,用于治疗哮喘。 |
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S5750 |
DL-Norepinephrine hydrochlorideNorepinephrine (noradrenaline) is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors. |
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S2362 |
SynephrineSynephrine (Oxedrine)是从苦橘及其他柑橘属植物中提取的一种不饱和的植物甾醇,常用于减肥。 |
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S9507 |
(−)-Norepinephrine(−)-Norepinephrine (Arterenol, Levarterenol)是一种天然存在的神经递质和激素。它是adrenergic receptors的激动剂,对α1, α2A和β1肾上腺素受体的Ki值分别为330 nM、56 nM和740 nM。 |
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S9508 |
BrimonidineBrimonidine (Bromoxidine, UK 1430) is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure. |
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S5751 |
Dihydroergotamine MesylateDihydroergotamine Mesylate is an ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors. |
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S5494 |
SalbutamolSalbutamol (Albuterol) is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases. |
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S5267 |
Nylidrin HydrochlorideNylidrin Hydrochloride (Buphenine), a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well. |
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S6487 |
fluticasone furoateFluticasone furoate (GW685698)是一种吸入性皮质类固醇/长效的β肾上腺素能受体激动剂的复方治疗药物,能延长支气管扩张剂的作用时间。它被用于非过敏性和过敏性皮炎的治疗。 |
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S3185 |
Adrenalone HClAdrenalone HCl是一种肾上腺素激动剂,作为外用的血管收缩剂和止血剂,主要作用于α-1肾上腺素受体。 |
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S3153 |
Levalbuterol tartrateLevalbuterol HCl是一种相对选择性的β2-肾上腺素受体激动剂,用于治疗哮喘。 |
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S4243 |
Deoxycorticosterone acetateDeoxycorticosterone acetate是一种类固醇激素,用于肌肉注射,是肾上腺皮质类固醇的代替疗法。 |
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S1324 |
Doxazosin MesylateDoxazosin Mesylate是一种α-1肾上腺素能受体抑制剂。 |
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S6345New |
3-Nitro-L-tyrosine3-Nitro-L-tyrosine (3-NT, N-Tyr, MNT) 是由过氧化亚硝酸盐从L-酪氨酸合成的,是一氧化氮和超氧化物的产物。3-Nitro-L-tyrosine 可通过抑制 alpha 1-adrenoceptor 介导的反应来抑制血管紧张素II引起的血液动力学反应。 |
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S4076 |
Propranolol HClPropranolol HCl (AY-64043, ICI-45520, NCS-91523) 是一种竞争性和非选择性β-肾上腺素受体抑制剂,IC50为12 nM. |
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S1206 |
Bisoprolol fumarateBisoprolol fumarate (EMD33512) 是一种选择性β1型肾上腺素能受体抑制剂。 |
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S4113 |
DesvenlafaxineDesvenlafaxine (WY 45233 Succinate)是一种5-羟色胺(5-HT)和去甲肾上腺素(NE)重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM。 |
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S5739 |
NebivololNebivolol (Bystolic) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure. |
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S5088 |
Labetalone hydrochlorideLabetalone hydrochloride (Benzoic amide)是labetalone的盐酸盐形式,labetalone是alpha- 和 beta-adrenergic receptors的阻滞剂,被用作一种降压药。 |
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S5703 |
Carvedilol PhosphateCarvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity. |
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S1642 |
MethyldopaMethyldopa 是DOPA 脱羧酶竞争性抑制剂,ED50为21.8 mg/kg。 |
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S5787 |
DronedaroneDronedarone (SR33589)是amiodarone的衍生物,是III类抗心律失常药。它能抑制与心率相关的快速Na+流、抑制α和β肾上腺素能受体、阻断K+外向离子流和Ca2+慢速内流。 |
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S4112 |
Desvenlafaxine SuccinateDesvenlafaxine Succinate (WY 45233) 是一种新型5-羟色胺(5-HT)转运蛋白 和去甲肾上腺素(NE)转运蛋白重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM |
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S2086 |
Ivabradine HClIvabradine HCl (S 16257-2)是一种新型If抑制剂,IC50为2.9 μM,特定有效作用于窦房结心脏起搏器活性,是一种纯粹的心跳速率降低剂。 |
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S9560 |
Anisodamine HydrobromideAnisodamine (6-Hydroxyhyoscyamine)是天然存在的阿托品(atropine)衍生物,具有消炎活性。它能抑制α1-adrenergic receptors和mAChRs。 |
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S2113 |
Cisatracurium BesylateCisatracurium Besylate是一种非去极化神经肌肉阻断剂,通过抑制神经肌肉的传导而对乙酰胆碱起拮抗作用。 |
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S5723 |
Carvedilol EP IMpurity ECarvedilol EP IMpurity E (Carvedilol USP E, Carvedilol Impurity E) is a nonselective beta blocker/alpha-1 blocker and used in management of congestive heart failure (CHF). |
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S3764 |
Isoferulic AcidIsoferulic acid (Hesperetic acid, Hesperetate, Isoferulate), a major active ingredient of Cimicifuga heracleifolia, shows anti-inflammatory, antiviral, antioxidant, and antidiabetic properties. |
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S1283 |
Asenapine maleateAsenapine maleate (Org 5222)是一种高亲和性的包括 serotonin, norepinephrine, dopamine 和 histamine receptors在内的多种受体的拮抗剂,用于治疗神经分裂症以及抑郁狂躁型忧郁症。 |
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S0812New |
SR59230ASR59230A 是一种血脑屏障穿透性的、有效的 β3-adrenergic receptor 的选择性拮抗剂,对β3、β1和β2受体的IC50分别为40 nM、408 nM和648 nM。 |
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S0116New |
Piperoxan hydrochloridePiperoxan hydrochloride (Benodaine, Fourneau 933, F933, DL-Piperoxan) 是 α2 (alpha 2) adrenoceptor 的拮抗剂。 |
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S1409 |
Alfuzosin HClAlfuzosin HCl 是一种α1受体拮抗剂,用于治疗良性前列腺增生(BPH)。 |
![]() ![]() PC-3 and LNCaP cell viability following treatment with a1-adrenoceptor antagonists. (A) Cells were treated with drug (0.01-100 μM) for 72 hr and cell viability determined using the resazurin reduction assay. (B) Effect of treatment duration on PC-3 and LNCap cell survival following treatment with doxazosin (30 μM) or prazosin (30 μM). Survival is expressed as the percentage values of untreated vehicle control and values are the mean ( sem) of six independent determinations each conducted in triplicate. *P<0.05, ***P<0.001 compared to corresponding values for LNCap cells.
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S1613 |
SilodosinSilodosin (KAD 3213, KMD 3213)是一种α1-肾上腺素受体拮抗剂,具有高泌尿选择性。 |
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S1549 |
Nebivolol HCl在兔肺β1-肾上腺素受体结合实验中,Nebivolol HCl (R-65824)选择性阻断β1受体,IC50为0.8 nM。 |
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S2691 |
BMY 7378 DihydrochlorideBMY 7378是一种多靶点抑制剂,作用于α2C-adrenoceptor和α1D-adrenoceptor,pKi分别为6.54和8.2,且为混合型5-HT1A受体激动剂和拮抗剂,pKi为8.3。 |
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S1424 |
Prazosin HClPrazosin HCl (cp-12299-1) 是Quinazoline 衍生物,是一种新型的化学类抗高血压药物。 |
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S2038 |
Phentolamine MesylatePhentolamine Mesylate是一种非选择性α-肾上腺素能拮抗剂,IC50为0.1 μM。 |
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S1856 |
Metoprolol TartrateMetoprolol Tartrate (CGP 2175E) 是一种心脏选择性的β-肾上腺素能受体抑制剂,IC50为42 ng/mL。 |
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S2059 |
Terazosin HCl DihydrateTerazosin HCl 是α-肾上腺素能受体抑制剂,用于治疗高血压和前列腺肥大。 |
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S1387 |
Naftopidil DiHClNaftopidil DiHCl (KT-611)是一种选择性5-HT1A和α1-adrenergic receptor(α1-肾上腺素受体)拮抗剂,IC50分别为0.1 μM和0.2 μM。 |
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S2517 |
Maprotiline HClMaprotiline HCl是一种选择性去甲肾上腺素再摄取抑制剂,也是一种四环类抗抑郁药。 |
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S1831 |
CarvedilolCarvedilol (BM-14190, SKF 105517)是一种非选择性β/α-1受体抑制剂,用于治疗充血性心力衰竭和高血压。 |
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S2126 |
NaftopidilNaftopidil (KT-611) 是选择性α1-肾上腺素能受体拮抗剂,或α受体抑制剂,Ki为58.3 nM。 |
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S2499 |
Phenoxybenzamine HClPhenoxybenzamine HCl (NSC 37448, NCI-c01661)是一种非选择性,不可逆α受体拮抗剂,IC50为550 nM。 |
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S2509 |
Sotalol HClSotalol 是一种非选择性β受体抑制剂,是钾离子通道抑制剂,IC50为43 μM。 |
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S4123 |
Timolol MaleateTimolol Maleate (MK-950)是一种非选择性的β-肾上腺素能受体拮抗剂,作用于β1/β2,Ki为1.97 nM/2.0 nM。 |
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S4010 |
Acebutolol HClAcebutolol HCl是beta-adrenergic receptors(β-肾上腺素能受体)拮抗剂,用于治疗高血压,心绞痛,和心律失常。 |
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S1827 |
Betaxolol HClBetaxolol (SL 75212)是一种β1肾上腺素受体阻断剂,IC50是6 Μm。 |
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S2607 |
Buflomedil HClBuflomedil HCl是一种血管扩张剂,用于治疗跛行或外周动脉疾病的症状。是一种非选择性alpha adrenergic receptor抑制剂。 |
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S5540 |
Landiolol hydrochlorideLandiolol hydrochloride (ONO-1101) is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist. |
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S3664 |
Flupentixol dihydrochlorideFlupentixol (Flupenthixol) dihydrochloride 是一种抗精神病安定药物,是D1 and D2多巴胺受体的强效拮抗剂,也是α肾上腺素能受体的拮抗剂。 |
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S5802 |
Alprenolol hydrochlorideAlprenolol hydrochloride是alprenolol的盐酸盐形式。Alprenolol是beta adrenergic receptor拮抗剂,被用作抗高血压、减轻心绞痛和抗心律失常的试剂。 |
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S4124 |
Tolazoline HClTolazoline HCl是一种非选择性和竞争性的α-肾上腺素能受体拮抗剂。 |
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S5666 |
Moxisylyte hydrochlorideMoxisylyte hydrochloride (thymoxamine) is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease. |
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S5942 |
BisoprololBisoprolol是心脏选择性β1-adrenergic receptor阻滞剂,用于阻止心肌梗死、心力衰竭、心绞痛和轻中度高血压。 |
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S5766 |
AlfuzosinAlfuzosin是具有选择性的、竞争性α1肾上腺素能受体(α1-adrenoceptor)拮抗剂。 |
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S9285 |
FargesinFargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway. |
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S5281 |
Dapiprazole HydrochlorideDapiprazole Hydrochloride (Glamidolo Hydrochloride, Reversil Hydrochloride) is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination. |
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S5337 |
Rauwolscine hydrochlorideRauwolscine hydrochloride (Isoyohimbine, α-Yohimbine, corynanthidine) is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM. |
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S4649 |
Atipamezole hydrochlorideAtipamezole (Antisedan, MPV1248) 是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。Atipamezole hydrochloride是atipamezole的盐酸盐形式。 |
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S4650 |
AtipamezoleAtipamezole (MPV-1248, MPV1248, Antisedan)是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。 |
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S3656 |
PiribedilPiribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties. |
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S9050 |
BoldineBoldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects. |
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S1435 |
Tamsulosin hydrochlorideTamsulosin (Flomax) hydrochloride是一种作用于前列腺的α1A肾上腺素拮抗剂。 |
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S4679 |
Terazosin HClTerazosin (Hytrin, Zayasel, Terazosine, Flumarc, Fosfomic, Blavin)是一种选择性的alpha-1拮抗剂,用于治疗前列腺肿大症状。它通过抑制膀胱平滑肌和血管壁上的肾上腺素的作用发挥效应。 |
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S5780 |
PrazosinPrazosin是α1阻断剂,是alpha-1肾上腺素能受体的反向激动剂。 |
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S4085 |
Levobetaxolol HClLevobetaxolol (AL 1577A)高亲和力作用于克隆的人β1和β2受体,Ki分别为0.76 nM和32.6 nM。 |
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S5042 |
Bevantolol hydrochlorideBevantolol hydrochloride (NC-1400) 选择性β肾上腺素受体拮抗剂,没有β内源性拟交感活性,膜稳定性较弱,具有局部麻醉作用。 |
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S5778 |
EsmololEsmolol是心脏选择性β1阻断剂,能迅速发挥作用、持续时间短,在治疗剂量下,对内在拟交感活性或膜稳定性没有显著影响。 |
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S8114 |
ICI-118551 HydrochlorideICI-118551是高选择性的β2肾上腺素受体拮抗剂,其对β2,β1和β3 受体的Ki值分别为0.7, 49.5和611 nM。 |
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S4100 |
Esmolol HClEsmolol (ASL8052) 是一种心脏选择性B受体阻滞剂,用于控制心跳急或异常心率节律。 |
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S5782 |
DoxazosinDoxazosin是一种喹唑啉衍生物,可选择性拮抗突触后α1肾上腺素能受体(α1-adrenergic receptors)。 |
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S5923 |
Celiprolol hydrochlorideCeliprolol是β1-adrenoceptor拮抗剂,具有部分β2受体激动剂活性。 |
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S6447 |
CarazololCarazolol是一种非特异性β肾上腺素能阻滞剂。 |
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S5023 |
NadololNadolol (Corgard, Solgol, Anabet, SQ11725) 是一种非选择性的β-肾上腺素能受体拮抗剂,具有抗高血压和抗心律失常活性。 |
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S5341 |
Metroprolol succinateMetoprolol Succinate (Metoprolol succinate) is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. |
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S5432 |
Dibenamine HydrochlorideDibenamine (N-(2-Chloroethyl)dibenzylamine, Sympatholytin, Dibenzylchlorethamine) is an irreversible blocker of α1 adrenoceptors. |
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S2091 |
BetaxololBetaxolol (SL 75212) 是一种选择性的β1肾上腺素能受体抑制剂,用于治疗高血压和青光眼。 |
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S4278 |
Carteolol HClCarteolol HCl 是一种β-adrenoceptor拮抗剂,用于治疗青光眼。 |
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S5430 |
MetoprololMetoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension. |
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S4817 |
AtenololAtenolol (Tenormin, Normiten, Blokium)是一种选择性的β1 receptor拮抗剂,对人源β1-, β2- 和β3-肾上腺受体的log Kd值分别为−6.66±0.05, −5.99±0.14, −4.11±0.07。 |
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S2373 |
Yohimbine HClYohimbine (Antagonil) 是一种瞳孔放大剂,用于治疗阳痿,也是一种春药。 |
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S4291 |
Labetalol HClLabetalol HCl是一种选择性alpha1-adrenergic 和非选择性beta-adrenergic receptors的双重拮抗剂,用于高血压的治疗。 |
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S4797 |
NicergolineNicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has a selective alpha-1A adrenergic receptor blocking property and also other additional mechanisms of actions. |
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S2507 |
Salbutamol SulfateSalbutamol Sulfate (Albuterol) 是一种短效的β2-肾上腺素能受体激动剂,IC50为8.93 µM。 |
![]() ![]() (B) Bar graphs summarize the incidence of VA from Con (An external file that holds a picture, illustration, etc. Object name is srep07681-m1.jpg) and HF (An external file that holds a picture, illustration, etc. Object name is srep07681-m2.jpg) guinea pigs before and after administration of Sal (10 μM) or Sal plus ICI (1 μM) (*p < 0.05, HF + Sal vs. Con + Sal; #p < 0.05, HF + Sal vs. HF + Sal + ICI, n = 6).
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S4009 |
MirabegronMirabegron (YM 178)是一种选择性的beta3-adrenoceptor(β3肾上腺素受体)激动剂,EC50为22.4 nM。 |
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S2516 |
Xylazine HClXylazine HCl是一种α2肾上腺素能受体激动剂,用作镇定剂和肌肉松弛剂。 |
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S3294New |
Demethyl-CoclaurineDemethyl-Coclaurine (Higenamine, Norcoclaurine) 是中草药乌头根的关键成分,是一种 beta-2 adrenergic receptor (β2-AR) 的激动剂。Demethyl-Coclaurine 可刺激 AKT 的磷酸化,需要 PI3K 的激活才能使心肌细胞产生抗凋亡的作用。 |
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S3083 |
Indacaterol MaleateIndacaterol (QAB149)是一种超长效的β-adrenoceptor激动剂,对β1-adrenoceptor的pKi为 7.36,对 β2-adrenoceptor 的pKi为5.48。 |
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S2566 |
Isoprenaline HClIsoprenaline (NCI-c55630) 是一种非选择性β-肾上腺素能受体激动剂,用于治疗心动过缓和心传导阻滞。 |
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S2020 |
Formoterol HemifumarateFormoterol Hemifumarate (Eformoterol, CGP 25827A, NSC 299587, YM 08316)是一种有效的,选择性的,长效β2-adrenoceptor 激动剂,用于治疗哮喘以及慢性阻塞性肺病。 |
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S2521 |
Epinephrine bitartrateEpinephrine bitartrate (Adrenalinium)是一种α和β-肾上腺素能受体激动剂。 |
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S2458 |
Clonidine HClClonidine HCl 是一种直接起作用的α2肾上腺素能受体激动剂,ED50为0.02±0.01 mg/kg。 |
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S3041 |
DroxidopaDroxidopa (L-DOPS)是一种精神药物,是合成的氨基酸前体,它作为神经传导物质去甲肾上腺素和肾上腺素的前药来发挥作用。 |
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S3075 |
DexmedetomidineDexmedetomidine是特护病房和麻醉师使用的一种镇静剂。 |
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S2522 |
L-AdrenalineL-Adrenaline (Epinephrine) 属于儿茶酚胺类。 |
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S2569 |
Phenylephrine HClPhenylephrine HCl (NCI-c55641)是一种选择性的α1-肾上腺素能受体激动剂。 |
![]() ![]() (F) Fluo-4 AM-loaded EPLC-SMCs and HCASMCs displayed a change in cell surface area following phenylephrine stimulation. Scale bars, 100 μm. (G) Percentage change in cell surface area. Error bars represent SEM; n = 12 cells; **p < 0.01 versus D15 + 8 + 6 cells that did not exhibit calcium transients, analyzed by the Student's t-test. HCASMCs, human coronary artery smooth muscle cells; NS, no significant difference.
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S4065 |
Guanabenz AcetateGuanabenz Acetate (WY-8678) 是一种选择性的α2a-肾上腺素能受体, α2b-肾上腺素能受体和α2c-肾上腺素能受体激动剂,pEC50分别为8.25, 7.01和5左右。 |
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S2519 |
Naphazoline HClNaphazoline HCl 是一种眼部血管收缩剂,是咪唑啉衍生的拟交感胺类。 |
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S2533 |
Ritodrine HClRitodrine HCl (NSC 291565) 是Ritodrine的盐酸盐,是β-2肾上腺素能受体激动剂。 |
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S2438 |
Synephrine HClSynephrine HCl是一种交感神经α-adrenergic receptor (AR)(肾上腺素受体)激动剂。 |
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S2090 |
Dexmedetomidine HClDexmedetomidine HCl 是一种有效的,高度选择性α-2肾上腺素受体激动剂,具有显著的镇静效果,从而降低患者的麻醉量。 |
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S3061 |
Epinephrine HClEpinephrine HCl (Adrenaline) 是一种激素和神经递质。 |
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S3060 |
Medetomidine HClMedetomidine HCl是一种选择性的α2-adrenoceptor(α2-肾上腺素受体)激动剂,Ki为1.08 nM,比作用于α1-adrenoceptor选择性高1620倍。 |
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S1437 |
Tizanidine HClTizanidine HCl (DS 103-282)是一种α2-肾上腺素受体,抑制中枢神经系统去甲肾上腺素能神经的神经递质的释放。 |
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S2092 |
Detomidine HClDetomidine HCl可产生镇静和镇痛作用,这种作用具有剂量依赖性,通过激活α2儿茶酚胺受体来调节。 |
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S5537 |
TizanidineTizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity. |
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S2545 |
ScopineScopine是Anisodine的代谢产物,是一种α1-肾上腺素能受体激动剂,用于治疗急性循环性休克。 |
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S5527 |
SalmeterolSalmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500). |
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S4296 |
Salmeterol XinafoateSalmeterol Xinafoate是一种长效的β2-adrenergic receptor激动剂,具有抗炎作用,用于哮喘症状和慢性阻塞性肺疾病(COPD)症状的治疗。 |
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S2523 |
DL-AdrenalineDL-Adrenaline是一种激素,是由肾上腺髓质分泌的一种神经递质。 |
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S4266 |
Brimonidine TartrateBrimonidine Tartrate是一种高选择性的α-肾上腺素能受体激动剂,EC50为0.45 nM,用于治疗开角型青光眼或高眼压症。 |
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S3960 |
Higenamine hydrochlorideHigenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants. |
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S2615 |
Noradrenaline bitartrate monohydrateNoradrenaline bitartrate monohydrate (Levophed)是一种直接的α-肾上腺素能受体激动剂。 |
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S5768 |
Fenoterol hydrobromideFenoterol hydrobromide (Phenoterol)是fenoterol的氢溴酸盐。Fenoterol是β2 adrenoreceptor激动剂,具有支气管扩张活性。 |
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S7974 |
L755507L-755,507是一种有效的、选择性的β3肾上腺素能受体部分激动剂,EC50为0.43 nM。它能在iPSCs和其他细胞类型中增强CRISPR介导的同源重组修复效率。 |
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S5564 |
XylazineXylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. |
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S4127 |
Terbutaline SulfateTerbutaline Sulfate是一种选择性的β2-肾上腺素能受体激动剂,IC50为53 nM。 |
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S5769 |
FenoterolFenoterol (Phenoterol) 是β2 adrenoreceptor激动剂,具有支气管扩张活性。 |
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S5683 |
Isoproterenol sulfate dihydrateIsoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity. |
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S4135 |
Clorprenaline HClClorprenaline HCl (NSC 334693) 是β2-受体激动剂,具有显著的扩张支气管作用。 |
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S4043 |
Tetrahydrozoline HClTetrahydrozoline (Tetryzoline) HCl是一种咪唑啉衍生物,具有α受体激动剂活性。 |
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S5217 |
Arformoterol TartrateArformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity. |
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S5734 |
Midodrine hydrochlorideMidodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor. |
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S5735 |
MidodrineMidodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist. |
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S5727 |
TetryzolineTetryzoline (Tetrahydrozoline) is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays. |
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S2576 |
Xylometazoline HClXylometazoline HCl 是α-adrenoceptor激动剂,常用作鼻血管收缩药,高效作用于α2B肾上腺素受体亚型,EC50为4 μM。 |
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S3640 |
Methoxyphenamine HydrochlorideMethoxyphenamine Hydrochloride (2-methoxy-N-methylamphetamine, OMMA) is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator. |
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S3643 |
AmitrazAmitraz (NSC 324552) 是一种α2 肾上腺素能受体激动剂。它是非系统性杀螨剂和杀虫剂。 |
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S2304 |
GramineGramine (Donaxine) 是一种从巨型芦苇中分离出的天然吲哚生物碱,是一种活性脂联素受体(AdipoR)激动剂,对AdipoR2和AdipoR1的IC50分别为3.2 µM和4.2 µM。 禾胺也是人和小鼠 β2-Adrenergic receptor (β2-AR) 激动剂。 |
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S3727 |
Vilanterol TrifenateVilanterol trifenatate (GW642444M) is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma. |
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S6583 |
Apraclonidine HClApraclonidine (Iopidine)是一种拟交感神经要,用于治疗青光眼。它是α2-肾上腺素能受体激动剂。 |
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S4693 |
Guanfacine HydrochlorideGuanfacine Hydrochloride (Tenex, Intuniv)是一种选择性的α2A-肾上腺素受体激动剂,具有降压效果。 |
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S5669 |
Isoxsuprine hydrochlorideIsoxsuprine hydrochloride是β-肾上腺素能受体(beta-adrenergic)激动剂,具有血管扩张活性。 |
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S5654 |
IndacaterolIndacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor. |
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S5925 |
Olodaterol hydrochlorideOlodaterol hydrochloride (BI-1744)是Olodaterol的盐酸盐形式,Olodaterol是一种长效的β2肾上腺素能受体(beta2-adrenergic)激动剂。 |
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S2083 |
Procaterol HClProcaterol HCl (OPC-2009) 是短效的β2-肾上腺素能受体激动剂,Kp为8 nM,用于治疗哮喘。 |
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S4277 |
Bambuterol HClBambuterol HCl是强效β-adrenoceptor拮抗剂,用于治疗哮喘。 |
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S5750 |
DL-Norepinephrine hydrochlorideNorepinephrine (noradrenaline) is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors. |
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S2362 |
SynephrineSynephrine (Oxedrine)是从苦橘及其他柑橘属植物中提取的一种不饱和的植物甾醇,常用于减肥。 |
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S9507 |
(−)-Norepinephrine(−)-Norepinephrine (Arterenol, Levarterenol)是一种天然存在的神经递质和激素。它是adrenergic receptors的激动剂,对α1, α2A和β1肾上腺素受体的Ki值分别为330 nM、56 nM和740 nM。 |
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S9508 |
BrimonidineBrimonidine (Bromoxidine, UK 1430) is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure. |
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S5751 |
Dihydroergotamine MesylateDihydroergotamine Mesylate is an ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors. |
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S5494 |
SalbutamolSalbutamol (Albuterol) is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases. |
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S5267 |
Nylidrin HydrochlorideNylidrin Hydrochloride (Buphenine), a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well. |
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S6487 |
fluticasone furoateFluticasone furoate (GW685698)是一种吸入性皮质类固醇/长效的β肾上腺素能受体激动剂的复方治疗药物,能延长支气管扩张剂的作用时间。它被用于非过敏性和过敏性皮炎的治疗。 |
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S3185 |
Adrenalone HClAdrenalone HCl是一种肾上腺素激动剂,作为外用的血管收缩剂和止血剂,主要作用于α-1肾上腺素受体。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S3153 |
Levalbuterol tartrateLevalbuterol HCl是一种相对选择性的β2-肾上腺素受体激动剂,用于治疗哮喘。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S4243 |
Deoxycorticosterone acetateDeoxycorticosterone acetate是一种类固醇激素,用于肌肉注射,是肾上腺皮质类固醇的代替疗法。 |