Adrenergic Receptor

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研究领域

抑制剂选择性比较

特异性亚型抑制剂

Adrenergic Receptor产品

所有产品(145) Adrenergic Receptor抑制剂(16) Adrenergic Receptor激活剂(1) Adrenergic Receptor拮抗剂(59) Adrenergic Receptor激动剂(67) Adrenergic Receptor调节剂(1)

目录号	产品描述	文献引用	实验数据
S1324	Doxazosin Mesylate Doxazosin Mesylate是一种α-1肾上腺素能受体抑制剂。	J Ocul Pharmacol Ther, 2017, 33(1):50-56 Prostate, 2016, 76(8):757-66 Antiviral Res, 2015, 120:140-6
S3913^New	Pimethixene maleate Pimethixene (Pimetixene) maleate 是一种抗组胺药、抗焦虑药和抗血清素的化合物，是多种monoamine receptors，包括多种 serotonin receptors 的高效拮抗剂。Pimethixene maleate 可抑制5-HT2A、5-HT2B、5-HT2C、5-HT1A、5-HT1B、5-HT6、5-HT7、Adrenergic α-1A、Dopamine D1 Receptor、Dopamine D2 Receptor、Dopamine D4.4 Receptor、Histamine H1 Receptor、Muscarinic M1 和 Muscarinic M2，对应的pKi值分别为10.22、10.44、8.42、7.63、<5、7.30、7.28、7.61、6.37、8.19、7.54、10.14、8.61和9.38。
S6345^New	3-Nitro-L-tyrosine 3-Nitro-L-tyrosine (3-NT, N-Tyr, MNT) 是由过氧化亚硝酸盐从L-酪氨酸合成的，是一氧化氮和超氧化物的产物。3-Nitro-L-tyrosine 可通过抑制 alpha 1-adrenoceptor 介导的反应来抑制血管紧张素II引起的血液动力学反应。
S4076	Propranolol HCl Propranolol HCl (AY-64043, ICI-45520, NCS-91523) 是一种竞争性和非选择性β-肾上腺素受体抑制剂，IC50为12 nM.	Sci Rep, 2020, 10(1):10465 Drug Metab Dispos, 2020, 48(8):613-621
S1206	Bisoprolol fumarate Bisoprolol fumarate (EMD33512) 是一种选择性β1型肾上腺素能受体抑制剂。	Sci Rep, 2019, 9(1):3018 J Chromatogr B Analyt Technol Biomed Life Sci, 2019, 1129:121793 J Cell Mol Med, 2018, 22(12):5964-5977
S4113	Desvenlafaxine Desvenlafaxine (WY 45233 Succinate)是一种5-羟色胺(5-HT)和去甲肾上腺素(NE)重吸收抑制剂，K_i值分别为40.2 nM和558.4 nM。	Drug Metab Dispos, 2020, 48(10):1044-1052
S5739	Nebivolol Nebivolol (Bystolic) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.	Sci Rep, 2015, 5:16406
S5088	Labetalone hydrochloride Labetalone hydrochloride (Benzoic amide)是labetalone的盐酸盐形式，labetalone是alpha- 和 beta-adrenergic receptors的阻滞剂，被用作一种降压药。
S5703	Carvedilol Phosphate Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.
S1642	Methyldopa Methyldopa 是DOPA 脱羧酶竞争性抑制剂，ED50为21.8 mg/kg。
S5787	Dronedarone Dronedarone (SR33589)是amiodarone的衍生物，是III类抗心律失常药。它能抑制与心率相关的快速Na+流、抑制α和β肾上腺素能受体、阻断K+外向离子流和Ca2+慢速内流。
S4112	Desvenlafaxine Succinate Desvenlafaxine Succinate (WY 45233) 是一种新型5-羟色胺(5-HT)转运蛋白和去甲肾上腺素(NE)转运蛋白重吸收抑制剂，K_i值分别为40.2 nM和558.4 nM	Drug Metab Dispos, 2020, 48(10):1044-1052
S2086	Ivabradine HCl Ivabradine HCl (S 16257-2)是一种新型I_f抑制剂，IC50为2.9 μM，特定有效作用于窦房结心脏起搏器活性，是一种纯粹的心跳速率降低剂。	J Pain, 2018, 19(6):626-634
S9560	Anisodamine Hydrobromide Anisodamine (6-Hydroxyhyoscyamine)是天然存在的阿托品（atropine）衍生物，具有消炎活性。它能抑制α1-adrenergic receptors和mAChRs。
S2113	Cisatracurium Besylate Cisatracurium Besylate是一种非去极化神经肌肉阻断剂，通过抑制神经肌肉的传导而对乙酰胆碱起拮抗作用。	Biosci Trends, 2021, 15(1):50-54
S5723	Carvedilol EP IMpurity E Carvedilol EP IMpurity E (Carvedilol USP E, Carvedilol Impurity E) is a nonselective beta blocker/alpha-1 blocker and used in management of congestive heart failure (CHF).
S3764	Isoferulic Acid Isoferulic acid (Hesperetic acid, Hesperetate, Isoferulate), a major active ingredient of Cimicifuga heracleifolia, shows anti-inflammatory, antiviral, antioxidant, and antidiabetic properties.
S1283	Asenapine maleate Asenapine maleate (Org 5222)是一种高亲和性的包括 serotonin, norepinephrine, dopamine 和 histamine receptors在内的多种受体的拮抗剂，用于治疗神经分裂症以及抑郁狂躁型忧郁症。	Biochem Biophys Res Commun, 2021, 553:172-179 Sci Rep, 2018, 8(1):15753
S5981^New	S(-)-Propranolol hydrochloride (S)-(-)-Propranolol hydrochloride 是 propranolol的活性对映体，是 β-Adrenoceptor (β-Adrenergic Receptor) 的拮抗剂，对β1、β2和β3的Kd值分别为-8.16、-9.08和-6.93。
S5789^New	Propafenone Propafenone (SA-79) 是一种口服活性 sodium channel 的阻断剂和 beta-adrenoceptor (β-adrenergic receptor) 的拮抗剂。Propafenone 在治疗心律不齐方面具有广泛的活性。
S5965^New	Urapidil Urapidil 是一种降压药，可作为 α1 adrenoreceptor 的拮抗剂和 5-HT1A 激动剂。
S0812^New	SR59230A SR59230A 是一种血脑屏障穿透性的、有效的 β3-adrenergic receptor 的选择性拮抗剂，对β3、β1和β2受体的IC50分别为40 nM、408 nM和648 nM。
S1409	Alfuzosin HCl Alfuzosin HCl 是一种α1受体拮抗剂，用于治疗良性前列腺增生（BPH）。	Prostate, 2016, 76(8):757-66	PC-3 and LNCaP cell viability following treatment with a1-adrenoceptor antagonists. (A) Cells were treated with drug (0.01-100 μM) for 72 hr and cell viability determined using the resazurin reduction assay. (B) Effect of treatment duration on PC-3 and LNCap cell survival following treatment with doxazosin (30 μM) or prazosin (30 μM). Survival is expressed as the percentage values of untreated vehicle control and values are the mean ( sem) of six independent determinations each conducted in triplicate. P<0.05, **P<0.001 compared to corresponding values for LNCap cells.
S1613	Silodosin Silodosin (KAD 3213, KMD 3213)是一种α1-肾上腺素受体拮抗剂，具有高泌尿选择性。
S1549	Nebivolol hydrochloride (R-65824) 在兔肺β1-肾上腺素受体结合实验中，Nebivolol HCl (R-65824)选择性阻断β1受体，IC50为0.8 nM。	Cell Syst, 2019, 8(2):97-108
S2691	BMY 7378 Dihydrochloride BMY 7378是一种多靶点抑制剂，作用于α2C-adrenoceptor和α1D-adrenoceptor，pK_i分别为6.54和8.2，且为混合型5-HT1A受体激动剂和拮抗剂，pK_i为8.3。
S1424	Prazosin HCl Prazosin HCl (cp-12299-1) 是Quinazoline 衍生物，是一种新型的化学类抗高血压药物。	BMC Pharmacol Toxicol, 2020, 21(1):61
S2038	Phentolamine Mesylate Phentolamine Mesylate是一种非选择性α-肾上腺素能拮抗剂，IC50为0.1 μM。
S1856	Metoprolol Tartrate Metoprolol Tartrate (CGP 2175E) 是一种心脏选择性的β-肾上腺素能受体抑制剂，IC50为42 ng/mL。
S2059	Terazosin HCl Dihydrate Terazosin HCl 是α-肾上腺素能受体抑制剂，用于治疗高血压和前列腺肥大。	J Biomed Sci, 2021, 28(1):8
S1387	Naftopidil DiHCl Naftopidil DiHCl (KT-611)是一种选择性5-HT1A和α1-adrenergic receptor（α1-肾上腺素受体）拮抗剂，IC50分别为0.1 μM和0.2 μM。
S2517	Maprotiline HCl Maprotiline HCl是一种选择性去甲肾上腺素再摄取抑制剂，也是一种四环类抗抑郁药。
S1831	Carvedilol Carvedilol (BM-14190, SKF 105517)是一种非选择性β/α-1受体抑制剂，用于治疗充血性心力衰竭和高血压。	PLoS Pathog, 2020, 16;16(3):e1008341 Res Pharm Sci, 2015, 10(5):388-96
S2126	Naftopidil Naftopidil (KT-611) 是选择性α1-肾上腺素能受体拮抗剂，或α受体抑制剂，K_i为58.3 nM。	Cell Syst, 2019, 8(2):97-108
S2499	Phenoxybenzamine HCl Phenoxybenzamine HCl (NSC 37448, NCI-c01661)是一种非选择性，不可逆α受体拮抗剂，IC50为550 nM。
S2509	Sotalol HCl Sotalol 是一种非选择性β受体抑制剂，是钾离子通道抑制剂，IC50为43 μM。	Gynecol Oncol, 2018, 151(3):525-532 Toxicol Appl Pharmacol, 2015, 285(1):51-60
S4123	Timolol Maleate Timolol Maleate (MK-950)是一种非选择性的β-肾上腺素能受体拮抗剂，作用于β1/β2，K_i为1.97 nM/2.0 nM。	J Dermatolog Treat, 2020, 24:1-7
S4010	Acebutolol HCl Acebutolol HCl是beta-adrenergic receptors（β-肾上腺素能受体）拮抗剂，用于治疗高血压，心绞痛，和心律失常。
S1827	Betaxolol HCl Betaxolol (SL 75212)是一种β₁肾上腺素受体阻断剂，IC50是6 Μm。	Chirality, 2018, 30(11):1195-1205
S2607	Buflomedil HCl Buflomedil HCl是一种血管扩张剂，用于治疗跛行或外周动脉疾病的症状。是一种非选择性alpha adrenergic receptor抑制剂。
S5540	Landiolol hydrochloride Landiolol hydrochloride (ONO-1101) is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist.
S3664	Flupentixol dihydrochloride Flupentixol (Flupenthixol) dihydrochloride 是一种抗精神病安定药物，是D1 and D2多巴胺受体的强效拮抗剂，也是α肾上腺素能受体的拮抗剂。
S5802	Alprenolol hydrochloride Alprenolol hydrochloride是alprenolol的盐酸盐形式。Alprenolol是beta adrenergic receptor拮抗剂，被用作抗高血压、减轻心绞痛和抗心律失常的试剂。
S4124	Tolazoline HCl Tolazoline HCl是一种非选择性和竞争性的α-肾上腺素能受体拮抗剂。	Insect Biochem Mol Biol, 2017, 90:61-70
S5666	Moxisylyte hydrochloride Moxisylyte hydrochloride (thymoxamine) is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease.
S5942	Bisoprolol Bisoprolol是心脏选择性β1-adrenergic receptor阻滞剂，用于阻止心肌梗死、心力衰竭、心绞痛和轻中度高血压。
S5766	Alfuzosin Alfuzosin是具有选择性的、竞争性α1肾上腺素能受体（α1-adrenoceptor）拮抗剂。
S9285	Fargesin Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway.
S5281	Dapiprazole Hydrochloride Dapiprazole Hydrochloride (Glamidolo Hydrochloride, Reversil Hydrochloride) is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination.
S5337	Rauwolscine hydrochloride Rauwolscine hydrochloride (Isoyohimbine, α-Yohimbine, corynanthidine) is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM.	J Pharm Biomed Anal, 2020, 180:113019
S4649	Atipamezole hydrochloride Atipamezole (Antisedan, MPV1248) 是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。Atipamezole hydrochloride是atipamezole的盐酸盐形式。
S4650	Atipamezole Atipamezole (MPV-1248, MPV1248, Antisedan)是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。	Exp Mol Med, 2020, 10.1038/s12276-020-0461-6 Nitric Oxide, 2019, 85:1-9 Front Neurol, 2019, 10:1041
S0116	Piperoxan hydrochloride Piperoxan hydrochloride (Benodaine, Fourneau 933, F933, DL-Piperoxan) 是 α2 (alpha 2) adrenoceptor 的拮抗剂。
S3656	Piribedil Piribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.
S9050	Boldine Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.
S1435	Tamsulosin hydrochloride Tamsulosin (Flomax) hydrochloride是一种作用于前列腺的α1A肾上腺素拮抗剂。
S4679	Terazosin HCl Terazosin (Hytrin, Zayasel, Terazosine, Flumarc, Fosfomic, Blavin)是一种选择性的alpha-1拮抗剂，用于治疗前列腺肿大症状。它通过抑制膀胱平滑肌和血管壁上的肾上腺素的作用发挥效应。	J Biomed Sci, 2021, 28(1):8
S5780	Prazosin Prazosin是α1阻断剂，是alpha-1肾上腺素能受体的反向激动剂。	BMC Pharmacol Toxicol, 2020, 21(1):61
S4085	Levobetaxolol HCl Levobetaxolol (AL 1577A)高亲和力作用于克隆的人β1和β2受体，K_i分别为0.76 nM和32.6 nM。
S5042	Bevantolol hydrochloride Bevantolol hydrochloride (NC-1400) 选择性β肾上腺素受体拮抗剂，没有β内源性拟交感活性，膜稳定性较弱，具有局部麻醉作用。
S5778	Esmolol Esmolol是心脏选择性β1阻断剂，能迅速发挥作用、持续时间短，在治疗剂量下，对内在拟交感活性或膜稳定性没有显著影响。
S8114	ICI-118551 Hydrochloride ICI-118551是高选择性的β2肾上腺素受体拮抗剂，其对β2,β1和β3 受体的Ki值分别为0.7, 49.5和611 nM。	Sci Transl Med, 2020, 12(572)eabb5817 Sci Adv, 2020, 13;6(20):eaay1497 Neurogastroenterol Motil, 2020, 11;e13877
S4100	Esmolol HCl Esmolol (ASL8052) 是一种心脏选择性B受体阻滞剂，用于控制心跳急或异常心率节律。
S5782	Doxazosin Doxazosin是一种喹唑啉衍生物，可选择性拮抗突触后α1肾上腺素能受体（α1-adrenergic receptors）。
S5923	Celiprolol hydrochloride Celiprolol是β1-adrenoceptor拮抗剂，具有部分β2受体激动剂活性。
S6447	Carazolol Carazolol是一种非特异性β肾上腺素能阻滞剂。
S5023	Nadolol Nadolol (Corgard, Solgol, Anabet, SQ11725) 是一种非选择性的β-肾上腺素能受体拮抗剂，具有抗高血压和抗心律失常活性。
S5341	Metroprolol succinate Metroprolol Succinate (Metoprolol succinate) is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity.
S5432	Dibenamine Hydrochloride Dibenamine (N-(2-Chloroethyl)dibenzylamine, Sympatholytin, Dibenzylchlorethamine) is an irreversible blocker of α1 adrenoceptors.
S2091	Betaxolol Betaxolol (SL 75212) 是一种选择性的β1肾上腺素能受体抑制剂，用于治疗高血压和青光眼。	Nat Commun, 2020, 24;11(1):1990 Chirality, 2018, 30(11):1195-1205
S4278	Carteolol HCl Carteolol HCl 是一种β-adrenoceptor拮抗剂,用于治疗青光眼。
S5430	Metoprolol Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.
S4817	Atenolol Atenolol (Tenormin, Normiten, Blokium)是一种选择性的β1 receptor拮抗剂，对人源β1-, β2- 和β3-肾上腺受体的log Kd值分别为−6.66±0.05, −5.99±0.14, −4.11±0.07。
S2373	Yohimbine HCl Yohimbine (Antagonil) 是一种瞳孔放大剂，用于治疗阳痿，也是一种春药。	J Inflamm Res, 2021, 14:1217-1233 J Med Virol, 2019, 91(8):1440-1447
S4291	Labetalol HCl Labetalol HCl是一种选择性alpha1-adrenergic 和非选择性beta-adrenergic receptors的双重拮抗剂，用于高血压的治疗。
S4797	Nicergoline Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has a selective alpha-1A adrenergic receptor blocking property and also other additional mechanisms of actions.
S2507	Salbutamol Sulfate Salbutamol Sulfate (Albuterol) 是一种短效的β2-肾上腺素能受体激动剂，IC50为8.93 µM。	cell, 2020, 180(1):64-78.e16 Sci Signal, 2020, 13(659)eaax0273 BMC Pharmacol Toxicol, 2020, 21(1):61	(B) Bar graphs summarize the incidence of VA from Con (An external file that holds a picture, illustration, etc. Object name is srep07681-m1.jpg) and HF (An external file that holds a picture, illustration, etc. Object name is srep07681-m2.jpg) guinea pigs before and after administration of Sal (10 μM) or Sal plus ICI (1 μM) (*p < 0.05, HF + Sal vs. Con + Sal; #p < 0.05, HF + Sal vs. HF + Sal + ICI, n = 6).
S4009	Mirabegron Mirabegron (YM 178)是一种选择性的beta3-adrenoceptor（β3肾上腺素受体）激动剂，EC50为22.4 nM。	Cancer Cell Int, 2020, 19;20:58 Hum Cell, 2020, 10.1007/s13577-020-00425-8 Hum Cell, 2020, 10.1007/s13577-020-00420-z
S2516	Xylazine HCl Xylazine HCl是一种α2肾上腺素能受体激动剂，用作镇定剂和肌肉松弛剂。	Cell Host Microbe, 2018, 24(1):97-108 J Neurochem, 2018, 146(6):703-721 Biomed Rep, 2016, 5(3):357-360
S4485^New	Olodaterol (BI 1744) Olodaterol (BI 1744) 是一种长效的 β2-adrenergic receptor 的激动剂，可作为吸入剂(Tiotropium/Olodaterol)的成分之一，用于治疗慢性阻塞性肺疾病(COPD)患者。
S5954^New	L-(-)-α-Methyldopa hydrate L-(-)-α-Methyldopa (Methyldopa, MK-351) hydrate 是一种有效的降压药，是 α2-adrenergic receptors 的选择性激动剂。
S4481^New	Guanabenz Guanabenz (GBZ, GA, Wytensin, Wy-8678) 是一种具有抗高血压作用的中枢 alpha 2-adrenoceptor (α2 adrenergic receptor) 的口服活性激动剂。
S3294^New	Demethyl-Coclaurine Demethyl-Coclaurine (Higenamine, Norcoclaurine) 是中草药乌头根的关键成分，是一种 beta-2 adrenergic receptor (β2-AR) 的激动剂。Demethyl-Coclaurine 可刺激 AKT 的磷酸化，需要 PI3K 的激活才能使心肌细胞产生抗凋亡的作用。
S3083	Indacaterol Maleate Indacaterol (QAB149)是一种超长效的β-adrenoceptor激动剂，对β1-adrenoceptor的pK_i为 7.36，对 β2-adrenoceptor 的pK_i为5.48。
S2566	Isoprenaline (NCI-C55630) HCl Isoprenaline HCl (NCI-C55630)是一种非选择性β-肾上腺素能受体激动剂，用于治疗心动过缓和心传导阻滞。	PLoS Pathog, 2020, 16;16(3):e1008341
S2020	Formoterol Hemifumarate Formoterol Hemifumarate (Eformoterol, CGP 25827A, NSC 299587, YM 08316)是一种有效的，选择性的，长效β2-adrenoceptor 激动剂，用于治疗哮喘以及慢性阻塞性肺病。
S2521	Epinephrine bitartrate Epinephrine bitartrate (Adrenalinium)是一种α和β-肾上腺素能受体激动剂。	J Immunother Cancer, 2021, 9(1)e001466 Cancer Cell Int, 2020, 19;20:58 Hum Cell, 2020, 10.1007/s13577-020-00425-8
S2458	Clonidine HCl Clonidine HCl 是一种直接起作用的α2肾上腺素能受体激动剂，ED50为0.02±0.01 mg/kg。
S3041	Droxidopa Droxidopa (L-DOPS)是一种精神药物，是合成的氨基酸前体，它作为神经传导物质去甲肾上腺素和肾上腺素的前药来发挥作用。
S3075	Dexmedetomidine Dexmedetomidine是特护病房和麻醉师使用的一种镇静剂。	Exp Mol Med, 2020, 10.1038/s12276-020-0461-6 Exp Ther Med, 2020, 20(2):917-925 Steroids, 2019, 149:108423
S2522	L-Adrenaline L-Adrenaline (Epinephrine) 属于儿茶酚胺类。
S2569	Phenylephrine (NCI-C55641) HCl Phenylephrine HCl (NCI-C55641)是一种选择性的α1-肾上腺素能受体激动剂。	Oxid Med Cell Longev, 2021, 2021:7848027 Front Pharmacol, 2019, 10:465 Sci Adv, 2019, 5(5):eaau0495	(F) Fluo-4 AM-loaded EPLC-SMCs and HCASMCs displayed a change in cell surface area following phenylephrine stimulation. Scale bars, 100 μm. (G) Percentage change in cell surface area. Error bars represent SEM; n = 12 cells; **p < 0.01 versus D15 + 8 + 6 cells that did not exhibit calcium transients, analyzed by the Student's t-test. HCASMCs, human coronary artery smooth muscle cells; NS, no significant difference.
S4065	Guanabenz Acetate Guanabenz Acetate (WY-8678) 是一种选择性的α2a-肾上腺素能受体， α2b-肾上腺素能受体和α2c-肾上腺素能受体激动剂，pEC50分别为8.25， 7.01和5左右。	Cell Stem Cell, 2020, 27(6):876-889.e12 Thyroid, 2019, 29(6):809-823
S2519	Naphazoline HCl Naphazoline HCl 是一种眼部血管收缩剂，是咪唑啉衍生的拟交感胺类。
S2533	Ritodrine HCl Ritodrine HCl (NSC 291565) 是Ritodrine的盐酸盐，是β-2肾上腺素能受体激动剂。
S2438	Synephrine HCl Synephrine HCl是一种交感神经α-adrenergic receptor (AR)（肾上腺素受体）激动剂。
S2090	Dexmedetomidine HCl Dexmedetomidine HCl 是一种有效的，高度选择性α-2肾上腺素受体激动剂，具有显著的镇静效果，从而降低患者的麻醉量。	Exp Ther Med, 2020, 20(2):917-925
S3061	Epinephrine HCl Epinephrine HCl (Adrenaline) 是一种激素和神经递质。	J Immunother Cancer, 2021, 9(1)e001466
S3060	Medetomidine HCl Medetomidine HCl是一种选择性的α2-adrenoceptor（α2-肾上腺素受体）激动剂，K_i为1.08 nM，比作用于α1-adrenoceptor选择性高1620倍。	Micromachines, 2018, 9(6)
S1437	Tizanidine HCl Tizanidine HCl (DS 103-282)是一种α2-肾上腺素受体，抑制中枢神经系统去甲肾上腺素能神经的神经递质的释放。
S2092	Detomidine HCl Detomidine HCl可产生镇静和镇痛作用，这种作用具有剂量依赖性，通过激活α2儿茶酚胺受体来调节。	Nature, 2018, 560(7718):372-376
S5537	Tizanidine Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity.
S2545	Scopine Scopine是Anisodine的代谢产物，是一种α1-肾上腺素能受体激动剂，用于治疗急性循环性休克。
S5527	Salmeterol Salmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).	Drug Test Anal, 2020, 10.1002/dta.2917
S4296	Salmeterol Xinafoate Salmeterol Xinafoate是一种长效的β2-adrenergic receptor激动剂，具有抗炎作用，用于哮喘症状和慢性阻塞性肺疾病（COPD）症状的治疗。	ACS Pharmacol Transl Sci, 2019, 2(3):148-154 Commun Biol, 2018, 1:106
S2523	DL-Adrenaline DL-Adrenaline是一种激素，是由肾上腺髓质分泌的一种神经递质。
S4266	Brimonidine Tartrate Brimonidine Tartrate是一种高选择性的α-肾上腺素能受体激动剂，EC50为0.45 nM，用于治疗开角型青光眼或高眼压症。
S3960	Higenamine hydrochloride Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.
S2615	Noradrenaline bitartrate monohydrate Noradrenaline bitartrate monohydrate (Levophed)是一种直接的α-肾上腺素能受体激动剂。
S5768	Fenoterol hydrobromide Fenoterol hydrobromide (Phenoterol)是fenoterol的氢溴酸盐。Fenoterol是β2 adrenoreceptor激动剂，具有支气管扩张活性。
S0032	Batefenterol Batefenterol (GSK961081, TD-5959) 既是 muscarinic receptor 的拮抗剂又是 β2-adrenoceptor 的激动剂，hM2、hM3 muscarinic receptors 和 hβ2-adrenoceptor 的Ki值分别为1.4 nM、1.3 nM和3.7 nM。
S7974	L755507 L-755,507是一种有效的、选择性的β3肾上腺素能受体部分激动剂，EC50为0.43 nM。它能在iPSCs和其他细胞类型中增强CRISPR介导的同源重组修复效率。	Hum Mutat, 2019, 10.1002/humu.23848
S5564	Xylazine Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.	Cell Death Differ, 2020, 10.1038 Mol Med Rep, 2017, 16(2):1911-1919
S4127	Terbutaline Sulfate Terbutaline Sulfate是一种选择性的β2-肾上腺素能受体激动剂，IC50为53 nM。	BMC Pharmacol Toxicol, 2020, 21(1):61 Hum Reprod, 2016, 31(11):2506-2519
S5769	Fenoterol Fenoterol (Phenoterol) 是β2 adrenoreceptor激动剂，具有支气管扩张活性。
S5683	Isoproterenol sulfate dihydrate Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity.
S4135	Clorprenaline HCl Clorprenaline HCl (NSC 334693) 是β2-受体激动剂，具有显著的扩张支气管作用。
S4043	Tetrahydrozoline HCl Tetrahydrozoline (Tetryzoline) HCl是一种咪唑啉衍生物，具有α受体激动剂活性。
S5217	Arformoterol Tartrate Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity.
S5734	Midodrine hydrochloride Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor.
S5735	Midodrine Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.
S5727	Tetryzoline Tetryzoline (Tetrahydrozoline) is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays.
S2576	Xylometazoline HCl Xylometazoline HCl 是α-adrenoceptor激动剂，常用作鼻血管收缩药，高效作用于α_2B肾上腺素受体亚型，EC50为4 μM。
S3640	Methoxyphenamine Hydrochloride Methoxyphenamine Hydrochloride (2-methoxy-N-methylamphetamine, OMMA) is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.
S3643	Amitraz Amitraz (NSC 324552) 是一种α2 肾上腺素能受体激动剂。它是非系统性杀螨剂和杀虫剂。
S2304	Gramine Gramine (Donaxine) 是一种从巨型芦苇中分离出的天然吲哚生物碱，是一种活性脂联素受体（AdipoR）激动剂，对AdipoR2和AdipoR1的IC50分别为3.2 µM和4.2 µM。禾胺也是人和小鼠 β2-Adrenergic receptor (β2-AR) 激动剂。
S3727	Vilanterol Trifenate Vilanterol trifenatate (GW642444M) is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma.	J Neuroimmunol, 2019, 332:37-48
S6583	Apraclonidine HCl Apraclonidine (Iopidine)是一种拟交感神经要，用于治疗青光眼。它是α2-肾上腺素能受体激动剂。
S4693	Guanfacine Hydrochloride Guanfacine Hydrochloride (Tenex, Intuniv)是一种选择性的α2A-肾上腺素受体激动剂，具有降压效果。
S5669	Isoxsuprine hydrochloride Isoxsuprine hydrochloride是β-肾上腺素能受体（beta-adrenergic）激动剂，具有血管扩张活性。
S5654	Indacaterol Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.	Drug Test Anal, 2020, 10.1002/dta.2917 J Neuroimmunol, 2019, 332:37-48
S5925	Olodaterol hydrochloride Olodaterol hydrochloride (BI-1744)是Olodaterol的盐酸盐形式，Olodaterol是一种长效的β2肾上腺素能受体（beta2-adrenergic）激动剂。
S2083	Procaterol HCl Procaterol HCl (OPC-2009) 是短效的β2-肾上腺素能受体激动剂，K_p为8 nM，用于治疗哮喘。
S4277	Bambuterol HCl Bambuterol HCl是强效β-adrenoceptor拮抗剂，用于治疗哮喘。
S5750	DL-Norepinephrine hydrochloride Norepinephrine (noradrenaline) is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors.
S2362	Synephrine Synephrine (Oxedrine)是从苦橘及其他柑橘属植物中提取的一种不饱和的植物甾醇，常用于减肥。
S9507	(−)-Norepinephrine (−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline)是一种天然存在的神经递质和激素。它是adrenergic receptors的激动剂，对α1, α2A和β1肾上腺素受体的Ki值分别为330 nM、56 nM和740 nM。	Cardiovasc Drugs Ther, 2020, 11 Clin Sci (Lond), 2020, 134(14):1957-1971
S9508	Brimonidine Brimonidine (Bromoxidine, UK 1430) is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure.
S5751	Dihydroergotamine Mesylate Dihydroergotamine Mesylate is an ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors.
S5494	Salbutamol Salbutamol (Albuterol) is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases.	BMC Pharmacol Toxicol, 2020, 21(1):61
S5267	Nylidrin Hydrochloride Nylidrin Hydrochloride (Buphenine), a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well.
S6487	fluticasone furoate Fluticasone furoate (GW685698)是一种吸入性皮质类固醇/长效的β肾上腺素能受体激动剂的复方治疗药物，能延长支气管扩张剂的作用时间。它被用于非过敏性和过敏性皮炎的治疗。
S3185	Adrenalone HCl Adrenalone HCl是一种肾上腺素激动剂，作为外用的血管收缩剂和止血剂，主要作用于α-1肾上腺素受体。
S3153	Levalbuterol tartrate Levalbuterol HCl是一种相对选择性的β2-肾上腺素受体激动剂，用于治疗哮喘。
S4243	Deoxycorticosterone acetate Deoxycorticosterone acetate (11-Deoxycorticosterone, DOC, Cortexone)是一种类固醇激素，用于肌肉注射，是肾上腺皮质类固醇的代替疗法。	Nat Cancer, 2020, 1(2):235-248

目录号	产品描述	文献引用
S1324	Doxazosin Mesylate Doxazosin Mesylate是一种α-1肾上腺素能受体抑制剂。	J Ocul Pharmacol Ther,2017, 33(1):50-56 Prostate,2016, 76(8):757-66 Antiviral Res,2015, 120:140-6
S3913^New	Pimethixene maleate Pimethixene (Pimetixene) maleate 是一种抗组胺药、抗焦虑药和抗血清素的化合物，是多种monoamine receptors，包括多种 serotonin receptors 的高效拮抗剂。Pimethixene maleate 可抑制5-HT2A、5-HT2B、5-HT2C、5-HT1A、5-HT1B、5-HT6、5-HT7、Adrenergic α-1A、Dopamine D1 Receptor、Dopamine D2 Receptor、Dopamine D4.4 Receptor、Histamine H1 Receptor、Muscarinic M1 和 Muscarinic M2，对应的pKi值分别为10.22、10.44、8.42、7.63、<5、7.30、7.28、7.61、6.37、8.19、7.54、10.14、8.61和9.38。
S6345^New	3-Nitro-L-tyrosine 3-Nitro-L-tyrosine (3-NT, N-Tyr, MNT) 是由过氧化亚硝酸盐从L-酪氨酸合成的，是一氧化氮和超氧化物的产物。3-Nitro-L-tyrosine 可通过抑制 alpha 1-adrenoceptor 介导的反应来抑制血管紧张素II引起的血液动力学反应。
S4076	Propranolol HCl Propranolol HCl (AY-64043, ICI-45520, NCS-91523) 是一种竞争性和非选择性β-肾上腺素受体抑制剂，IC50为12 nM.	Sci Rep,2020, 10(1):10465 Drug Metab Dispos,2020, 48(8):613-621
S1206	Bisoprolol fumarate Bisoprolol fumarate (EMD33512) 是一种选择性β1型肾上腺素能受体抑制剂。	Sci Rep,2019, 9(1):3018 J Chromatogr B Analyt Technol Biomed Life Sci,2019, 1129:121793 J Cell Mol Med,2018, 22(12):5964-5977
S4113	Desvenlafaxine Desvenlafaxine (WY 45233 Succinate)是一种5-羟色胺(5-HT)和去甲肾上腺素(NE)重吸收抑制剂，K_i值分别为40.2 nM和558.4 nM。	Drug Metab Dispos,2020, 48(10):1044-1052
S5739	Nebivolol Nebivolol (Bystolic) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.	Sci Rep,2015, 5:16406
S5088	Labetalone hydrochloride Labetalone hydrochloride (Benzoic amide)是labetalone的盐酸盐形式，labetalone是alpha- 和 beta-adrenergic receptors的阻滞剂，被用作一种降压药。
S5703	Carvedilol Phosphate Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.
S1642	Methyldopa Methyldopa 是DOPA 脱羧酶竞争性抑制剂，ED50为21.8 mg/kg。
S5787	Dronedarone Dronedarone (SR33589)是amiodarone的衍生物，是III类抗心律失常药。它能抑制与心率相关的快速Na+流、抑制α和β肾上腺素能受体、阻断K+外向离子流和Ca2+慢速内流。
S4112	Desvenlafaxine Succinate Desvenlafaxine Succinate (WY 45233) 是一种新型5-羟色胺(5-HT)转运蛋白和去甲肾上腺素(NE)转运蛋白重吸收抑制剂，K_i值分别为40.2 nM和558.4 nM	Drug Metab Dispos,2020, 48(10):1044-1052
S2086	Ivabradine HCl Ivabradine HCl (S 16257-2)是一种新型I_f抑制剂，IC50为2.9 μM，特定有效作用于窦房结心脏起搏器活性，是一种纯粹的心跳速率降低剂。	J Pain,2018, 19(6):626-634
S9560	Anisodamine Hydrobromide Anisodamine (6-Hydroxyhyoscyamine)是天然存在的阿托品（atropine）衍生物，具有消炎活性。它能抑制α1-adrenergic receptors和mAChRs。
S2113	Cisatracurium Besylate Cisatracurium Besylate是一种非去极化神经肌肉阻断剂，通过抑制神经肌肉的传导而对乙酰胆碱起拮抗作用。	Biosci Trends,2021, 15(1):50-54
S5723	Carvedilol EP IMpurity E Carvedilol EP IMpurity E (Carvedilol USP E, Carvedilol Impurity E) is a nonselective beta blocker/alpha-1 blocker and used in management of congestive heart failure (CHF).

目录号	产品描述	文献引用	实验数据
S3764	Isoferulic Acid Isoferulic acid (Hesperetic acid, Hesperetate, Isoferulate), a major active ingredient of Cimicifuga heracleifolia, shows anti-inflammatory, antiviral, antioxidant, and antidiabetic properties.

目录号

产品描述

文献引用

实验数据

S3764

Isoferulic Acid

Isoferulic acid (Hesperetic acid, Hesperetate, Isoferulate), a major active ingredient of Cimicifuga heracleifolia, shows anti-inflammatory, antiviral, antioxidant, and antidiabetic properties.

目录号	产品描述	文献引用	实验数据
S1283	Asenapine maleate Asenapine maleate (Org 5222)是一种高亲和性的包括 serotonin, norepinephrine, dopamine 和 histamine receptors在内的多种受体的拮抗剂，用于治疗神经分裂症以及抑郁狂躁型忧郁症。	Biochem Biophys Res Commun, 2021, 553:172-179 Sci Rep, 2018, 8(1):15753
S5981^New	S(-)-Propranolol hydrochloride (S)-(-)-Propranolol hydrochloride 是 propranolol的活性对映体，是 β-Adrenoceptor (β-Adrenergic Receptor) 的拮抗剂，对β1、β2和β3的Kd值分别为-8.16、-9.08和-6.93。
S5789^New	Propafenone Propafenone (SA-79) 是一种口服活性 sodium channel 的阻断剂和 beta-adrenoceptor (β-adrenergic receptor) 的拮抗剂。Propafenone 在治疗心律不齐方面具有广泛的活性。
S5965^New	Urapidil Urapidil 是一种降压药，可作为 α1 adrenoreceptor 的拮抗剂和 5-HT1A 激动剂。
S0812^New	SR59230A SR59230A 是一种血脑屏障穿透性的、有效的 β3-adrenergic receptor 的选择性拮抗剂，对β3、β1和β2受体的IC50分别为40 nM、408 nM和648 nM。
S1409	Alfuzosin HCl Alfuzosin HCl 是一种α1受体拮抗剂，用于治疗良性前列腺增生（BPH）。	Prostate, 2016, 76(8):757-66	PC-3 and LNCaP cell viability following treatment with a1-adrenoceptor antagonists. (A) Cells were treated with drug (0.01-100 μM) for 72 hr and cell viability determined using the resazurin reduction assay. (B) Effect of treatment duration on PC-3 and LNCap cell survival following treatment with doxazosin (30 μM) or prazosin (30 μM). Survival is expressed as the percentage values of untreated vehicle control and values are the mean ( sem) of six independent determinations each conducted in triplicate. P<0.05, **P<0.001 compared to corresponding values for LNCap cells.
S1613	Silodosin Silodosin (KAD 3213, KMD 3213)是一种α1-肾上腺素受体拮抗剂，具有高泌尿选择性。
S1549	Nebivolol hydrochloride (R-65824) 在兔肺β1-肾上腺素受体结合实验中，Nebivolol HCl (R-65824)选择性阻断β1受体，IC50为0.8 nM。	Cell Syst, 2019, 8(2):97-108
S2691	BMY 7378 Dihydrochloride BMY 7378是一种多靶点抑制剂，作用于α2C-adrenoceptor和α1D-adrenoceptor，pK_i分别为6.54和8.2，且为混合型5-HT1A受体激动剂和拮抗剂，pK_i为8.3。
S1424	Prazosin HCl Prazosin HCl (cp-12299-1) 是Quinazoline 衍生物，是一种新型的化学类抗高血压药物。	BMC Pharmacol Toxicol, 2020, 21(1):61
S2038	Phentolamine Mesylate Phentolamine Mesylate是一种非选择性α-肾上腺素能拮抗剂，IC50为0.1 μM。
S1856	Metoprolol Tartrate Metoprolol Tartrate (CGP 2175E) 是一种心脏选择性的β-肾上腺素能受体抑制剂，IC50为42 ng/mL。
S2059	Terazosin HCl Dihydrate Terazosin HCl 是α-肾上腺素能受体抑制剂，用于治疗高血压和前列腺肥大。	J Biomed Sci, 2021, 28(1):8
S1387	Naftopidil DiHCl Naftopidil DiHCl (KT-611)是一种选择性5-HT1A和α1-adrenergic receptor（α1-肾上腺素受体）拮抗剂，IC50分别为0.1 μM和0.2 μM。
S2517	Maprotiline HCl Maprotiline HCl是一种选择性去甲肾上腺素再摄取抑制剂，也是一种四环类抗抑郁药。
S1831	Carvedilol Carvedilol (BM-14190, SKF 105517)是一种非选择性β/α-1受体抑制剂，用于治疗充血性心力衰竭和高血压。	PLoS Pathog, 2020, 16;16(3):e1008341 Res Pharm Sci, 2015, 10(5):388-96
S2126	Naftopidil Naftopidil (KT-611) 是选择性α1-肾上腺素能受体拮抗剂，或α受体抑制剂，K_i为58.3 nM。	Cell Syst, 2019, 8(2):97-108
S2499	Phenoxybenzamine HCl Phenoxybenzamine HCl (NSC 37448, NCI-c01661)是一种非选择性，不可逆α受体拮抗剂，IC50为550 nM。
S2509	Sotalol HCl Sotalol 是一种非选择性β受体抑制剂，是钾离子通道抑制剂，IC50为43 μM。	Gynecol Oncol, 2018, 151(3):525-532 Toxicol Appl Pharmacol, 2015, 285(1):51-60
S4123	Timolol Maleate Timolol Maleate (MK-950)是一种非选择性的β-肾上腺素能受体拮抗剂，作用于β1/β2，K_i为1.97 nM/2.0 nM。	J Dermatolog Treat, 2020, 24:1-7
S4010	Acebutolol HCl Acebutolol HCl是beta-adrenergic receptors（β-肾上腺素能受体）拮抗剂，用于治疗高血压，心绞痛，和心律失常。
S1827	Betaxolol HCl Betaxolol (SL 75212)是一种β₁肾上腺素受体阻断剂，IC50是6 Μm。	Chirality, 2018, 30(11):1195-1205
S2607	Buflomedil HCl Buflomedil HCl是一种血管扩张剂，用于治疗跛行或外周动脉疾病的症状。是一种非选择性alpha adrenergic receptor抑制剂。
S5540	Landiolol hydrochloride Landiolol hydrochloride (ONO-1101) is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist.
S3664	Flupentixol dihydrochloride Flupentixol (Flupenthixol) dihydrochloride 是一种抗精神病安定药物，是D1 and D2多巴胺受体的强效拮抗剂，也是α肾上腺素能受体的拮抗剂。
S5802	Alprenolol hydrochloride Alprenolol hydrochloride是alprenolol的盐酸盐形式。Alprenolol是beta adrenergic receptor拮抗剂，被用作抗高血压、减轻心绞痛和抗心律失常的试剂。
S4124	Tolazoline HCl Tolazoline HCl是一种非选择性和竞争性的α-肾上腺素能受体拮抗剂。	Insect Biochem Mol Biol, 2017, 90:61-70
S5666	Moxisylyte hydrochloride Moxisylyte hydrochloride (thymoxamine) is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease.
S5942	Bisoprolol Bisoprolol是心脏选择性β1-adrenergic receptor阻滞剂，用于阻止心肌梗死、心力衰竭、心绞痛和轻中度高血压。
S5766	Alfuzosin Alfuzosin是具有选择性的、竞争性α1肾上腺素能受体（α1-adrenoceptor）拮抗剂。
S9285	Fargesin Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway.
S5281	Dapiprazole Hydrochloride Dapiprazole Hydrochloride (Glamidolo Hydrochloride, Reversil Hydrochloride) is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination.
S5337	Rauwolscine hydrochloride Rauwolscine hydrochloride (Isoyohimbine, α-Yohimbine, corynanthidine) is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM.	J Pharm Biomed Anal, 2020, 180:113019
S4649	Atipamezole hydrochloride Atipamezole (Antisedan, MPV1248) 是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。Atipamezole hydrochloride是atipamezole的盐酸盐形式。
S4650	Atipamezole Atipamezole (MPV-1248, MPV1248, Antisedan)是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。	Exp Mol Med, 2020, 10.1038/s12276-020-0461-6 Nitric Oxide, 2019, 85:1-9 Front Neurol, 2019, 10:1041
S0116	Piperoxan hydrochloride Piperoxan hydrochloride (Benodaine, Fourneau 933, F933, DL-Piperoxan) 是 α2 (alpha 2) adrenoceptor 的拮抗剂。
S3656	Piribedil Piribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.
S9050	Boldine Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.
S1435	Tamsulosin hydrochloride Tamsulosin (Flomax) hydrochloride是一种作用于前列腺的α1A肾上腺素拮抗剂。
S4679	Terazosin HCl Terazosin (Hytrin, Zayasel, Terazosine, Flumarc, Fosfomic, Blavin)是一种选择性的alpha-1拮抗剂，用于治疗前列腺肿大症状。它通过抑制膀胱平滑肌和血管壁上的肾上腺素的作用发挥效应。	J Biomed Sci, 2021, 28(1):8
S5780	Prazosin Prazosin是α1阻断剂，是alpha-1肾上腺素能受体的反向激动剂。	BMC Pharmacol Toxicol, 2020, 21(1):61
S4085	Levobetaxolol HCl Levobetaxolol (AL 1577A)高亲和力作用于克隆的人β1和β2受体，K_i分别为0.76 nM和32.6 nM。
S5042	Bevantolol hydrochloride Bevantolol hydrochloride (NC-1400) 选择性β肾上腺素受体拮抗剂，没有β内源性拟交感活性，膜稳定性较弱，具有局部麻醉作用。
S5778	Esmolol Esmolol是心脏选择性β1阻断剂，能迅速发挥作用、持续时间短，在治疗剂量下，对内在拟交感活性或膜稳定性没有显著影响。
S8114	ICI-118551 Hydrochloride ICI-118551是高选择性的β2肾上腺素受体拮抗剂，其对β2,β1和β3 受体的Ki值分别为0.7, 49.5和611 nM。	Sci Transl Med, 2020, 12(572)eabb5817 Sci Adv, 2020, 13;6(20):eaay1497 Neurogastroenterol Motil, 2020, 11;e13877
S4100	Esmolol HCl Esmolol (ASL8052) 是一种心脏选择性B受体阻滞剂，用于控制心跳急或异常心率节律。
S5782	Doxazosin Doxazosin是一种喹唑啉衍生物，可选择性拮抗突触后α1肾上腺素能受体（α1-adrenergic receptors）。
S5923	Celiprolol hydrochloride Celiprolol是β1-adrenoceptor拮抗剂，具有部分β2受体激动剂活性。
S6447	Carazolol Carazolol是一种非特异性β肾上腺素能阻滞剂。
S5023	Nadolol Nadolol (Corgard, Solgol, Anabet, SQ11725) 是一种非选择性的β-肾上腺素能受体拮抗剂，具有抗高血压和抗心律失常活性。
S5341	Metroprolol succinate Metroprolol Succinate (Metoprolol succinate) is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity.
S5432	Dibenamine Hydrochloride Dibenamine (N-(2-Chloroethyl)dibenzylamine, Sympatholytin, Dibenzylchlorethamine) is an irreversible blocker of α1 adrenoceptors.
S2091	Betaxolol Betaxolol (SL 75212) 是一种选择性的β1肾上腺素能受体抑制剂，用于治疗高血压和青光眼。	Nat Commun, 2020, 24;11(1):1990 Chirality, 2018, 30(11):1195-1205
S4278	Carteolol HCl Carteolol HCl 是一种β-adrenoceptor拮抗剂,用于治疗青光眼。
S5430	Metoprolol Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.
S4817	Atenolol Atenolol (Tenormin, Normiten, Blokium)是一种选择性的β1 receptor拮抗剂，对人源β1-, β2- 和β3-肾上腺受体的log Kd值分别为−6.66±0.05, −5.99±0.14, −4.11±0.07。
S2373	Yohimbine HCl Yohimbine (Antagonil) 是一种瞳孔放大剂，用于治疗阳痿，也是一种春药。	J Inflamm Res, 2021, 14:1217-1233 J Med Virol, 2019, 91(8):1440-1447
S4291	Labetalol HCl Labetalol HCl是一种选择性alpha1-adrenergic 和非选择性beta-adrenergic receptors的双重拮抗剂，用于高血压的治疗。
S4797	Nicergoline Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has a selective alpha-1A adrenergic receptor blocking property and also other additional mechanisms of actions.

目录号	产品描述	文献引用	实验数据
S2507	Salbutamol Sulfate Salbutamol Sulfate (Albuterol) 是一种短效的β2-肾上腺素能受体激动剂，IC50为8.93 µM。	cell, 2020, 180(1):64-78.e16 Sci Signal, 2020, 13(659)eaax0273 BMC Pharmacol Toxicol, 2020, 21(1):61	(B) Bar graphs summarize the incidence of VA from Con (An external file that holds a picture, illustration, etc. Object name is srep07681-m1.jpg) and HF (An external file that holds a picture, illustration, etc. Object name is srep07681-m2.jpg) guinea pigs before and after administration of Sal (10 μM) or Sal plus ICI (1 μM) (*p < 0.05, HF + Sal vs. Con + Sal; #p < 0.05, HF + Sal vs. HF + Sal + ICI, n = 6).
S4009	Mirabegron Mirabegron (YM 178)是一种选择性的beta3-adrenoceptor（β3肾上腺素受体）激动剂，EC50为22.4 nM。	Cancer Cell Int, 2020, 19;20:58 Hum Cell, 2020, 10.1007/s13577-020-00425-8 Hum Cell, 2020, 10.1007/s13577-020-00420-z
S2516	Xylazine HCl Xylazine HCl是一种α2肾上腺素能受体激动剂，用作镇定剂和肌肉松弛剂。	Cell Host Microbe, 2018, 24(1):97-108 J Neurochem, 2018, 146(6):703-721 Biomed Rep, 2016, 5(3):357-360
S4485^New	Olodaterol (BI 1744) Olodaterol (BI 1744) 是一种长效的 β2-adrenergic receptor 的激动剂，可作为吸入剂(Tiotropium/Olodaterol)的成分之一，用于治疗慢性阻塞性肺疾病(COPD)患者。
S5954^New	L-(-)-α-Methyldopa hydrate L-(-)-α-Methyldopa (Methyldopa, MK-351) hydrate 是一种有效的降压药，是 α2-adrenergic receptors 的选择性激动剂。
S4481^New	Guanabenz Guanabenz (GBZ, GA, Wytensin, Wy-8678) 是一种具有抗高血压作用的中枢 alpha 2-adrenoceptor (α2 adrenergic receptor) 的口服活性激动剂。
S3294^New	Demethyl-Coclaurine Demethyl-Coclaurine (Higenamine, Norcoclaurine) 是中草药乌头根的关键成分，是一种 beta-2 adrenergic receptor (β2-AR) 的激动剂。Demethyl-Coclaurine 可刺激 AKT 的磷酸化，需要 PI3K 的激活才能使心肌细胞产生抗凋亡的作用。
S3083	Indacaterol Maleate Indacaterol (QAB149)是一种超长效的β-adrenoceptor激动剂，对β1-adrenoceptor的pK_i为 7.36，对 β2-adrenoceptor 的pK_i为5.48。
S2566	Isoprenaline (NCI-C55630) HCl Isoprenaline HCl (NCI-C55630)是一种非选择性β-肾上腺素能受体激动剂，用于治疗心动过缓和心传导阻滞。	PLoS Pathog, 2020, 16;16(3):e1008341
S2020	Formoterol Hemifumarate Formoterol Hemifumarate (Eformoterol, CGP 25827A, NSC 299587, YM 08316)是一种有效的，选择性的，长效β2-adrenoceptor 激动剂，用于治疗哮喘以及慢性阻塞性肺病。
S2521	Epinephrine bitartrate Epinephrine bitartrate (Adrenalinium)是一种α和β-肾上腺素能受体激动剂。	J Immunother Cancer, 2021, 9(1)e001466 Cancer Cell Int, 2020, 19;20:58 Hum Cell, 2020, 10.1007/s13577-020-00425-8
S2458	Clonidine HCl Clonidine HCl 是一种直接起作用的α2肾上腺素能受体激动剂，ED50为0.02±0.01 mg/kg。
S3041	Droxidopa Droxidopa (L-DOPS)是一种精神药物，是合成的氨基酸前体，它作为神经传导物质去甲肾上腺素和肾上腺素的前药来发挥作用。
S3075	Dexmedetomidine Dexmedetomidine是特护病房和麻醉师使用的一种镇静剂。	Exp Mol Med, 2020, 10.1038/s12276-020-0461-6 Exp Ther Med, 2020, 20(2):917-925 Steroids, 2019, 149:108423
S2522	L-Adrenaline L-Adrenaline (Epinephrine) 属于儿茶酚胺类。
S2569	Phenylephrine (NCI-C55641) HCl Phenylephrine HCl (NCI-C55641)是一种选择性的α1-肾上腺素能受体激动剂。	Oxid Med Cell Longev, 2021, 2021:7848027 Front Pharmacol, 2019, 10:465 Sci Adv, 2019, 5(5):eaau0495	(F) Fluo-4 AM-loaded EPLC-SMCs and HCASMCs displayed a change in cell surface area following phenylephrine stimulation. Scale bars, 100 μm. (G) Percentage change in cell surface area. Error bars represent SEM; n = 12 cells; **p < 0.01 versus D15 + 8 + 6 cells that did not exhibit calcium transients, analyzed by the Student's t-test. HCASMCs, human coronary artery smooth muscle cells; NS, no significant difference.
S4065	Guanabenz Acetate Guanabenz Acetate (WY-8678) 是一种选择性的α2a-肾上腺素能受体， α2b-肾上腺素能受体和α2c-肾上腺素能受体激动剂，pEC50分别为8.25， 7.01和5左右。	Cell Stem Cell, 2020, 27(6):876-889.e12 Thyroid, 2019, 29(6):809-823
S2519	Naphazoline HCl Naphazoline HCl 是一种眼部血管收缩剂，是咪唑啉衍生的拟交感胺类。
S2533	Ritodrine HCl Ritodrine HCl (NSC 291565) 是Ritodrine的盐酸盐，是β-2肾上腺素能受体激动剂。
S2438	Synephrine HCl Synephrine HCl是一种交感神经α-adrenergic receptor (AR)（肾上腺素受体）激动剂。
S2090	Dexmedetomidine HCl Dexmedetomidine HCl 是一种有效的，高度选择性α-2肾上腺素受体激动剂，具有显著的镇静效果，从而降低患者的麻醉量。	Exp Ther Med, 2020, 20(2):917-925
S3061	Epinephrine HCl Epinephrine HCl (Adrenaline) 是一种激素和神经递质。	J Immunother Cancer, 2021, 9(1)e001466
S3060	Medetomidine HCl Medetomidine HCl是一种选择性的α2-adrenoceptor（α2-肾上腺素受体）激动剂，K_i为1.08 nM，比作用于α1-adrenoceptor选择性高1620倍。	Micromachines, 2018, 9(6)
S1437	Tizanidine HCl Tizanidine HCl (DS 103-282)是一种α2-肾上腺素受体，抑制中枢神经系统去甲肾上腺素能神经的神经递质的释放。
S2092	Detomidine HCl Detomidine HCl可产生镇静和镇痛作用，这种作用具有剂量依赖性，通过激活α2儿茶酚胺受体来调节。	Nature, 2018, 560(7718):372-376
S5537	Tizanidine Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity.
S2545	Scopine Scopine是Anisodine的代谢产物，是一种α1-肾上腺素能受体激动剂，用于治疗急性循环性休克。
S5527	Salmeterol Salmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).	Drug Test Anal, 2020, 10.1002/dta.2917
S4296	Salmeterol Xinafoate Salmeterol Xinafoate是一种长效的β2-adrenergic receptor激动剂，具有抗炎作用，用于哮喘症状和慢性阻塞性肺疾病（COPD）症状的治疗。	ACS Pharmacol Transl Sci, 2019, 2(3):148-154 Commun Biol, 2018, 1:106
S2523	DL-Adrenaline DL-Adrenaline是一种激素，是由肾上腺髓质分泌的一种神经递质。
S4266	Brimonidine Tartrate Brimonidine Tartrate是一种高选择性的α-肾上腺素能受体激动剂，EC50为0.45 nM，用于治疗开角型青光眼或高眼压症。
S3960	Higenamine hydrochloride Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.
S2615	Noradrenaline bitartrate monohydrate Noradrenaline bitartrate monohydrate (Levophed)是一种直接的α-肾上腺素能受体激动剂。
S5768	Fenoterol hydrobromide Fenoterol hydrobromide (Phenoterol)是fenoterol的氢溴酸盐。Fenoterol是β2 adrenoreceptor激动剂，具有支气管扩张活性。
S0032	Batefenterol Batefenterol (GSK961081, TD-5959) 既是 muscarinic receptor 的拮抗剂又是 β2-adrenoceptor 的激动剂，hM2、hM3 muscarinic receptors 和 hβ2-adrenoceptor 的Ki值分别为1.4 nM、1.3 nM和3.7 nM。
S7974	L755507 L-755,507是一种有效的、选择性的β3肾上腺素能受体部分激动剂，EC50为0.43 nM。它能在iPSCs和其他细胞类型中增强CRISPR介导的同源重组修复效率。	Hum Mutat, 2019, 10.1002/humu.23848
S5564	Xylazine Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.	Cell Death Differ, 2020, 10.1038 Mol Med Rep, 2017, 16(2):1911-1919
S4127	Terbutaline Sulfate Terbutaline Sulfate是一种选择性的β2-肾上腺素能受体激动剂，IC50为53 nM。	BMC Pharmacol Toxicol, 2020, 21(1):61 Hum Reprod, 2016, 31(11):2506-2519
S5769	Fenoterol Fenoterol (Phenoterol) 是β2 adrenoreceptor激动剂，具有支气管扩张活性。
S5683	Isoproterenol sulfate dihydrate Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity.
S4135	Clorprenaline HCl Clorprenaline HCl (NSC 334693) 是β2-受体激动剂，具有显著的扩张支气管作用。
S4043	Tetrahydrozoline HCl Tetrahydrozoline (Tetryzoline) HCl是一种咪唑啉衍生物，具有α受体激动剂活性。
S5217	Arformoterol Tartrate Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity.
S5734	Midodrine hydrochloride Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor.
S5735	Midodrine Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.
S5727	Tetryzoline Tetryzoline (Tetrahydrozoline) is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays.
S2576	Xylometazoline HCl Xylometazoline HCl 是α-adrenoceptor激动剂，常用作鼻血管收缩药，高效作用于α_2B肾上腺素受体亚型，EC50为4 μM。
S3640	Methoxyphenamine Hydrochloride Methoxyphenamine Hydrochloride (2-methoxy-N-methylamphetamine, OMMA) is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.
S3643	Amitraz Amitraz (NSC 324552) 是一种α2 肾上腺素能受体激动剂。它是非系统性杀螨剂和杀虫剂。
S2304	Gramine Gramine (Donaxine) 是一种从巨型芦苇中分离出的天然吲哚生物碱，是一种活性脂联素受体（AdipoR）激动剂，对AdipoR2和AdipoR1的IC50分别为3.2 µM和4.2 µM。禾胺也是人和小鼠 β2-Adrenergic receptor (β2-AR) 激动剂。
S3727	Vilanterol Trifenate Vilanterol trifenatate (GW642444M) is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma.	J Neuroimmunol, 2019, 332:37-48
S6583	Apraclonidine HCl Apraclonidine (Iopidine)是一种拟交感神经要，用于治疗青光眼。它是α2-肾上腺素能受体激动剂。
S4693	Guanfacine Hydrochloride Guanfacine Hydrochloride (Tenex, Intuniv)是一种选择性的α2A-肾上腺素受体激动剂，具有降压效果。
S5669	Isoxsuprine hydrochloride Isoxsuprine hydrochloride是β-肾上腺素能受体（beta-adrenergic）激动剂，具有血管扩张活性。
S5654	Indacaterol Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.	Drug Test Anal, 2020, 10.1002/dta.2917 J Neuroimmunol, 2019, 332:37-48
S5925	Olodaterol hydrochloride Olodaterol hydrochloride (BI-1744)是Olodaterol的盐酸盐形式，Olodaterol是一种长效的β2肾上腺素能受体（beta2-adrenergic）激动剂。
S2083	Procaterol HCl Procaterol HCl (OPC-2009) 是短效的β2-肾上腺素能受体激动剂，K_p为8 nM，用于治疗哮喘。
S4277	Bambuterol HCl Bambuterol HCl是强效β-adrenoceptor拮抗剂，用于治疗哮喘。
S5750	DL-Norepinephrine hydrochloride Norepinephrine (noradrenaline) is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors.
S2362	Synephrine Synephrine (Oxedrine)是从苦橘及其他柑橘属植物中提取的一种不饱和的植物甾醇，常用于减肥。
S9507	(−)-Norepinephrine (−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline)是一种天然存在的神经递质和激素。它是adrenergic receptors的激动剂，对α1, α2A和β1肾上腺素受体的Ki值分别为330 nM、56 nM和740 nM。	Cardiovasc Drugs Ther, 2020, 11 Clin Sci (Lond), 2020, 134(14):1957-1971
S9508	Brimonidine Brimonidine (Bromoxidine, UK 1430) is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure.
S5751	Dihydroergotamine Mesylate Dihydroergotamine Mesylate is an ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors.
S5494	Salbutamol Salbutamol (Albuterol) is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases.	BMC Pharmacol Toxicol, 2020, 21(1):61
S5267	Nylidrin Hydrochloride Nylidrin Hydrochloride (Buphenine), a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well.
S6487	fluticasone furoate Fluticasone furoate (GW685698)是一种吸入性皮质类固醇/长效的β肾上腺素能受体激动剂的复方治疗药物，能延长支气管扩张剂的作用时间。它被用于非过敏性和过敏性皮炎的治疗。
S3185	Adrenalone HCl Adrenalone HCl是一种肾上腺素激动剂，作为外用的血管收缩剂和止血剂，主要作用于α-1肾上腺素受体。

目录号	产品描述	文献引用	实验数据
S3153	Levalbuterol tartrate Levalbuterol HCl是一种相对选择性的β2-肾上腺素受体激动剂，用于治疗哮喘。

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S3153

Levalbuterol tartrate

Levalbuterol HCl是一种相对选择性的β2-肾上腺素受体激动剂，用于治疗哮喘。

目录号	产品描述	文献引用	实验数据
S4243	Deoxycorticosterone acetate Deoxycorticosterone acetate (11-Deoxycorticosterone, DOC, Cortexone)是一种类固醇激素，用于肌肉注射，是肾上腺皮质类固醇的代替疗法。	Nat Cancer, 2020, 1(2):235-248

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S4243