Adrenergic Receptor

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抑制剂选择性比较

特异性亚型抑制剂

Adrenergic Receptor产品

所有产品 Adrenergic Receptor抑制剂(12) Adrenergic Receptor拮抗剂(52) Adrenergic Receptor激动剂(59) Adrenergic Receptor化学产品(2) 新Adrenergic Receptor产品

产品目录	产品描述	文献引用	实验数据
S1324	Doxazosin Mesylate Doxazosin Mesylate是一种α-1肾上腺素能受体抑制剂。	J Clin Invest, 2013, 123(12):5119-34 Antiviral Res, 2015, 120:140-6 J Ocul Pharmacol Ther, 2017, 33(1):50-56
S5703^New	Carvedilol Phosphate Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.
S5723^New	Carvedilol EP IMpurity E Carvedilol is a nonselective beta blocker/alpha-1 blocker and used in management of congestive heart failure (CHF).
S5739^New	Nebivolol Nebivolol is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.
S4076	Propranolol HCl Propranolol HCl是一种竞争性和非选择性β-肾上腺素受体抑制剂，IC50为12 nM.
S1206	Bisoprolol fumarate Bisoprolol fumarate是一种选择性β1型肾上腺素能受体抑制剂。	J Cell Mol Med, 2018, 22(12):5964-5977 J Toxicol Sci, 2017, 42(6):755-761
S4113	Desvenlafaxine Desvenlafaxine是一种5-羟色胺(5-HT)和去甲肾上腺素(NE)重吸收抑制剂，K_i值分别为40.2 nM和558.4 nM。
S5088	Labetalone hydrochloride Labetalone hydrochloride是labetalone的盐酸盐形式，labetalone是alpha- 和 beta-adrenergic receptors的阻滞剂，被用作一种降压药。
S1642	Methyldopa Methyldopa 是DOPA 脱羧酶竞争性抑制剂，ED50为21.8 mg/kg。
S4112	Desvenlafaxine Succinate Desvenlafaxine Succinate是一种新型5-羟色胺(5-HT)转运蛋白和去甲肾上腺素(NE)转运蛋白重吸收抑制剂，K_i值分别为40.2 nM和558.4 nM
S2086	Ivabradine HCl Ivabradine HCl是一种新型I_f抑制剂，IC50为2.9 μM，特定有效作用于窦房结心脏起搏器活性，是一种纯粹的心跳速率降低剂。
S2113	Cisatracurium Besylate Cisatracurium Besylate是一种非去极化神经肌肉阻断剂，通过抑制神经肌肉的传导而对乙酰胆碱起拮抗作用。
S1283	Asenapine maleate Asenapine maleate是一种高亲和性的包括 serotonin, norepinephrine, dopamine 和 histamine receptors在内的多种受体的拮抗剂，用于治疗神经分裂症以及抑郁狂躁型忧郁症。
S6447^New	Carazolol Carazolol是一种非特异性β肾上腺素能阻滞剂。
S5942^New	Bisoprolol Bisoprolol是心脏选择性β1-adrenergic receptor阻滞剂，用于阻止心肌梗死、心力衰竭、心绞痛和轻中度高血压。
S5782^New	Doxazosin Doxazosin是一种喹唑啉衍生物，可选择性拮抗突触后α1肾上腺素能受体（α1-adrenergic receptors）。
S5923^New	Celiprolol hydrochloride Celiprolol是β1-adrenoceptor拮抗剂，具有部分β2受体激动剂活性。
S5778^New	Esmolol Esmolol是心脏选择性β1阻断剂，能迅速发挥作用、持续时间短，在治疗剂量下，对内在拟交感活性或膜稳定性没有显著影响。
S5780^New	Prazosin Prazosin是α1阻断剂，是alpha-1肾上腺素能受体的反向激动剂。
S5766^New	Alfuzosin Alfuzosin是具有选择性的、竞争性α1肾上腺素能受体（α1-adrenoceptor）拮抗剂。
S5802^New	Alprenolol hydrochloride Alprenolol hydrochloride是alprenolol的盐酸盐形式。Alprenolol是beta adrenergic receptor拮抗剂，被用作抗高血压、减轻心绞痛和抗心律失常的试剂。
S5666^New	Moxisylyte hydrochloride Moxisylyte hydrochloride is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease.
S9285^New	Fargesin Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway.
s9050^New	Boldine Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.
S1435^New	Tamsulosin hydrochloride Tamsulosin hydrochloride是一种作用于前列腺的α1A肾上腺素拮抗剂。
S5540^New	Landiolol hydrochloride Landiolol hydrochloride is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist.
S5341^New	Metroprolol succinate Metoprolol Succinate is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity.
S5430^New	Metoprolol Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.
S5281^New	Dapiprazole Hydrochloride Dapiprazole Hydrochloride is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination.
S5432^New	Dibenamine Hydrochloride Dibenamine is an irreversible blocker of α1 adrenoceptors.
S5337^New	Rauwolscine hydrochloride Rauwolscine hydrochloride is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM.
S1409	Alfuzosin HCl Alfuzosin HCl 是一种α1受体拮抗剂，用于治疗良性前列腺增生（BPH）。	Prostate, 2016, 76(8):757-66	PC-3 and LNCaP cell viability following treatment with a1-adrenoceptor antagonists. (A) Cells were treated with drug (0.01-100 μM) for 72 hr and cell viability determined using the resazurin reduction assay. (B) Effect of treatment duration on PC-3 and LNCap cell survival following treatment with doxazosin (30 μM) or prazosin (30 μM). Survival is expressed as the percentage values of untreated vehicle control and values are the mean ( sem) of six independent determinations each conducted in triplicate. P<0.05, **P<0.001 compared to corresponding values for LNCap cells.
S1613	Silodosin Silodosin是一种α1-肾上腺素受体拮抗剂，具有高泌尿选择性。
S1549	Nebivolol HCl 在兔肺β1-肾上腺素受体结合实验中，Nebivolol HCl选择性阻断β1受体，IC50为0.8 nM。
S2691	BMY 7378 Dihydrochloride BMY 7378是一种多靶点抑制剂，作用于α2C-adrenoceptor和α1D-adrenoceptor，pK_i分别为6.54和8.2，且为混合型5-HT1A受体激动剂和拮抗剂，pK_i为8.3。
S1424	Prazosin HCl Prazosin HCl是Quinazoline 衍生物，是一种新型的化学类抗高血压药物。
S2038	Phentolamine Mesylate Phentolamine Mesylate是一种非选择性α-肾上腺素能拮抗剂，IC50为0.1 μM。
S1856	Metoprolol Tartrate Metoprolol Tartrate是一种心脏选择性的β-肾上腺素能受体抑制剂，IC50为42 ng/mL。
S2059	Terazosin HCl Dihydrate Terazosin HCl 是α-肾上腺素能受体抑制剂，用于治疗高血压和前列腺肥大。
S1387	Naftopidil DiHCl Naftopidil DiHCl是一种选择性5-HT1A和α1-adrenergic receptor（α1-肾上腺素受体）拮抗剂，IC50分别为0.1 μM和0.2 μM。
S2517	Maprotiline HCl Maprotiline HCl是一种选择性去甲肾上腺素再摄取抑制剂，也是一种四环类抗抑郁药。
S1831	Carvedilol Carvedilol是一种非选择性β/α-1受体抑制剂，用于治疗充血性心力衰竭和高血压。	Res Pharm Sci, 2015, 10(5):388-96
S2126	Naftopidil Naftopidil 是选择性α1-肾上腺素能受体拮抗剂，或α受体抑制剂，K_i为58.3 nM。
S2499	Phenoxybenzamine HCl Phenoxybenzamine HCl是一种非选择性，不可逆α受体拮抗剂，IC50为550 nM。
S2509	Sotalol HCl Sotalol 是一种非选择性β受体抑制剂，是钾离子通道抑制剂，IC50为43 μM。	Toxicol Appl Pharmacol, 2015, 285(1):51-60 Gynecol Oncol, 2018, 151(3):525-532
S4123	Timolol Maleate Timolol Maleate是一种非选择性的β-肾上腺素能受体拮抗剂，作用于β1/β2，K_i为1.97 nM/2.0 nM。
S4010	Acebutolol HCl Acebutolol HCl是beta-adrenergic receptors（β-肾上腺素能受体）拮抗剂，用于治疗高血压，心绞痛，和心律失常。
S1827	Betaxolol HCl Betaxolol HCl是一种β₁肾上腺素受体阻断剂，IC50是6 Μm。
S2607	Buflomedil HCl Buflomedil HCl是一种血管扩张剂，用于治疗跛行或外周动脉疾病的症状。是一种非选择性alpha adrenergic receptor抑制剂。
S3664	Flupenthixol dihydrochloride Flupentixol是一种抗精神病安定药物，是D1 and D2多巴胺受体的强效拮抗剂，也是α肾上腺素能受体的拮抗剂。
S4124	Tolazoline HCl Tolazoline HCl是一种非选择性和竞争性的α-肾上腺素能受体拮抗剂。	Insect Biochem Mol Biol, 2017, 90:61-70
S4649	Atipamezole hydrochloride Atipamezole是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。Atipamezole hydrochloride是atipamezole的盐酸盐形式。
S4650	Atipamezole Atipamezole是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。
S3656	Piribedil Piribedil is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.
S4679	Terazosin HCl Terazosin是一种选择性的alpha-1拮抗剂，用于治疗前列腺肿大症状。它通过抑制膀胱平滑肌和血管壁上的肾上腺素的作用发挥效应。
S4085	Levobetaxolol HCl Levobetaxolol高亲和力作用于克隆的人β1和β2受体，K_i分别为0.76 nM和32.6 nM。
S5042	Bevantolol hydrochloride Bevantolol hydrochloride选择性β肾上腺素受体拮抗剂，没有β内源性拟交感活性，膜稳定性较弱，具有局部麻醉作用。
S8114	ICI-118551 Hydrochloride ICI-118551是高选择性的β2肾上腺素受体拮抗剂，其对β2,β1和β3 受体的Ki值分别为0.7, 49.5和611 nM。
S4100	Esmolol HCl Esmolol是一种心脏选择性B受体阻滞剂，用于控制心跳急或异常心率节律。
S2091	Betaxolol Betaxolol是一种选择性的β1肾上腺素能受体抑制剂，用于治疗高血压和青光眼。
S4278	Carteolol HCl Carteolol HCl 是一种β-adrenoceptor拮抗剂,用于治疗青光眼。
S4817	Atenolol Atenolol是一种选择性的β1 receptor拮抗剂，对人源β1-, β2- 和β3-肾上腺受体的log Kd值分别为−6.66±0.05, −5.99±0.14, −4.11±0.07。
S2373	Yohimbine HCl Yohimbine HCl 是一种瞳孔放大剂，用于治疗阳痿，也是一种春药。
S4291	Labetalol HCl Labetalol HCl是一种选择性alpha1-adrenergic 和非选择性beta-adrenergic receptors的双重拮抗剂，用于高血压的治疗。
S2507	Salbutamol Sulfate Salbutamol Sulfate是一种短效的β2-肾上腺素能受体激动剂，IC50为8.93 µM。	Eur J Immunol, 2016, 1948-58 Sci Rep, 2015, 5:7681	(B) Bar graphs summarize the incidence of VA from Con (An external file that holds a picture, illustration, etc. Object name is srep07681-m1.jpg) and HF (An external file that holds a picture, illustration, etc. Object name is srep07681-m2.jpg) guinea pigs before and after administration of Sal (10 μM) or Sal plus ICI (1 μM) (*p < 0.05, HF + Sal vs. Con + Sal; #p < 0.05, HF + Sal vs. HF + Sal + ICI, n = 6).
S4009	Mirabegron Mirabegron是一种选择性的beta3-adrenoceptor（β3肾上腺素受体）激动剂，EC50为22.4 nM。	Andrologia, 2019, 10.1111/and.13241
S2516	Xylazine HCl Xylazine HCl是一种α2肾上腺素能受体激动剂，用作镇定剂和肌肉松弛剂。	Biomed Rep, 2016, 5(3):357-360 Acad Radiol, 2012, 19(3):358-65 J Neurochem, 2018, 146(6):703-721
S2083^New	Procaterol HCl Procaterol HCl是短效的β2-肾上腺素能受体激动剂，K_p为8 nM，用于治疗哮喘。
S5925^New	Olodaterol hydrochloride Olodaterol hydrochloride是Olodaterol的盐酸盐形式，Olodaterol是一种长效的β2肾上腺素能受体（beta2-adrenergic）激动剂。
S5669^New	Isoxsuprine hydrochloride Isoxsuprine hydrochloride是β-肾上腺素能受体（beta-adrenergic）激动剂，具有血管扩张活性。
S5768^New	Fenoterol hydrobromide Fenoterol hydrobromide是fenoterol的氢溴酸盐。Fenoterol是β2 adrenoreceptor激动剂，具有支气管扩张活性。
S5769^New	Fenoterol Fenoterol是β2 adrenoreceptor激动剂，具有支气管扩张活性。
S5683^New	Isoproterenol sulfate dihydrate Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity.
S5750^New	DL-Norepinephrine hydrochloride Norepinephrine is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors.
S5751^New	Dihydroergotamine Mesylate Dihydroergotamine Mesylate is an ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors.
S9507^New	(−)-Norepinephrine (−)-Norepinephrine是一种天然存在的神经递质和激素。它是adrenergic receptors的激动剂，对α1, α2A和β1肾上腺素受体的Ki值分别为330 nM、56 nM和740 nM。
S9508^New	Brimonidine Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure.
S5564^New	Xylazine Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.
S5727^New	Tetryzoline Tetryzoline is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays.
S5734^New	Midodrine hydrochloride Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor.
S5735^New	Midodrine Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.
S5217^New	Arformoterol Tartrate Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity.
S5654^New	Indacaterol Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.
S5267^New	Nylidrin Hydrochloride Nylidrin Hydrochloride, a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well.
S5537^New	Tizanidine
S5494^New	Salbutamol Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases.
S5527^New	Salmeterol Salmeterol is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).
S3083	Indacaterol Maleate Indacaterol Maleate是一种超长效的β-adrenoceptor激动剂，对β1-adrenoceptor的pK_i为 7.36，对 β2-adrenoceptor 的pK_i为5.48。
S2566	Isoprenaline HCl Isoprenaline是一种非选择性β-肾上腺素能受体激动剂，用于治疗心动过缓和心传导阻滞。
S2020	Formoterol Hemifumarate Formoterol Hemifumarate是一种有效的，选择性的，长效β2-adrenoceptor 激动剂，用于治疗哮喘以及慢性阻塞性肺病。
S2521	Epinephrine bitartrate Epinephrine Bitartrate 是一种α和β-肾上腺素能受体激动剂。
S2458	Clonidine HCl Clonidine HCl 是一种直接起作用的α2肾上腺素能受体激动剂，ED50为0.02±0.01 mg/kg。
S3041	Droxidopa Droxidopa是一种精神药物，是合成的氨基酸前体，它作为神经传导物质去甲肾上腺素和肾上腺素的前药来发挥作用。
S3075	Dexmedetomidine Dexmedetomidine是特护病房和麻醉师使用的一种镇静剂。
S2522	L-Adrenaline L-Adrenaline属于儿茶酚胺类。
S2569	Phenylephrine HCl Phenylephrine HCl是一种选择性的α1-肾上腺素能受体激动剂。	Stem Cells Dev, 2017, 26(7):528-540	(F) Fluo-4 AM-loaded EPLC-SMCs and HCASMCs displayed a change in cell surface area following phenylephrine stimulation. Scale bars, 100 μm. (G) Percentage change in cell surface area. Error bars represent SEM; n = 12 cells; **p < 0.01 versus D15 + 8 + 6 cells that did not exhibit calcium transients, analyzed by the Student's t-test. HCASMCs, human coronary artery smooth muscle cells; NS, no significant difference.
S4065	Guanabenz Acetate Guanabenz Acetate是一种选择性的α2a-肾上腺素能受体， α2b-肾上腺素能受体和α2c-肾上腺素能受体激动剂，pEC50分别为8.25， 7.01和5左右。
S2519	Naphazoline HCl Naphazoline HCl 是一种眼部血管收缩剂，是咪唑啉衍生的拟交感胺类。
S2533	Ritodrine HCl Ritodrine HCl 是Ritodrine的盐酸盐，是β-2肾上腺素能受体激动剂。
S2438	Synephrine HCl Synephrine HCl是一种交感神经α-adrenergic receptor (AR)（肾上腺素受体）激动剂。
S2090	Dexmedetomidine HCl Dexmedetomidine HCl 是一种有效的，高度选择性α-2肾上腺素受体激动剂，具有显著的镇静效果，从而降低患者的麻醉量。
S3061	Epinephrine HCl Epinephrine HCl是一种激素和神经递质。
S3060	Medetomidine HCl Medetomidine HCl是一种选择性的α2-adrenoceptor（α2-肾上腺素受体）激动剂，K_i为1.08 nM，比作用于α1-adrenoceptor选择性高1620倍。	Micromachines, 2018, 9(6)
S1437	Tizanidine HCl Tizanidine HCl是一种α2-肾上腺素受体，抑制中枢神经系统去甲肾上腺素能神经的神经递质的释放。
S2092	Detomidine HCl Detomidine HCl可产生镇静和镇痛作用，这种作用具有剂量依赖性，通过激活α2儿茶酚胺受体来调节。	Nature, 2018, 560(7718):372-376
S2545	Scopine Scopine是Anisodine的代谢产物，是一种α1-肾上腺素能受体激动剂，用于治疗急性循环性休克。
S4296	Salmeterol Xinafoate Salmeterol Xinafoate是一种长效的β2-adrenergic receptor激动剂，具有抗炎作用，用于哮喘症状和慢性阻塞性肺疾病（COPD）症状的治疗。
S2523	DL-Adrenaline DL-Adrenaline是一种激素，是由肾上腺髓质分泌的一种神经递质。
S4266	Brimonidine Tartrate Brimonidine Tartrate是一种高选择性的α-肾上腺素能受体激动剂，EC50为0.45 nM，用于治疗开角型青光眼或高眼压症。
S3960	Higenamine hydrochloride Higenamine, also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.
S2615	Noradrenaline bitartrate monohydrate Noradrenaline bitartrate monohydrate 是一种直接的α-肾上腺素能受体激动剂。
S7974	L755507 L-755,507是一种有效的、选择性的β3肾上腺素能受体部分激动剂，EC50为0.43 nM。它能在iPSCs和其他细胞类型中增强CRISPR介导的同源重组修复效率。
S4127	Terbutaline Sulfate Terbutaline Sulfate是一种选择性的β2-肾上腺素能受体激动剂，IC50为53 nM。
S4135	Clorprenaline HCl Clorprenaline HCl是β2-受体激动剂，具有显著的扩张支气管作用。
S4043	Tetrahydrozoline HCl Tetrahydrozoline HCl是一种咪唑啉衍生物，具有α受体激动剂活性。
S2576	Xylometazoline HCl Xylometazoline HCl 是α-adrenoceptor激动剂，常用作鼻血管收缩药，高效作用于α_2B肾上腺素受体亚型，EC50为4 μM。
S3640	Methoxyphenamine Hydrochloride Methoxyphenamine Hydrochloride is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.
S3643	Amitraz Amitraz是一种α2 肾上腺素能受体激动剂。它是非系统性杀螨剂和杀虫剂。
S3727	Vilanterol Trifenate Vilanterol trifenatate is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma.
S4693	Guanfacine Hydrochloride Guanfacine Hydrochloride是一种选择性的α2A-肾上腺素受体激动剂，具有降压效果。
S4277	Bambuterol HCl Bambuterol HCl是强效β-adrenoceptor拮抗剂，用于治疗哮喘。
S2362	Synephrine Synephrine是从苦橘及其他柑橘属植物中提取的一种不饱和的植物甾醇，常用于减肥。
S3185	Adrenalone HCl Adrenalone HCl是一种肾上腺素激动剂，作为外用的血管收缩剂和止血剂，主要作用于α-1肾上腺素受体。
S9560^New	Anisodamine Hydrobromide Anisodamine是天然存在的阿托品（atropine）衍生物，具有消炎活性。它能抑制α1-adrenergic receptors和mAChRs。
S4243	Deoxycorticosterone acetate Deoxycorticosterone acetate是一种类固醇激素，用于肌肉注射，是肾上腺皮质类固醇的代替疗法。

产品目录	产品描述	文献引用
S1324	Doxazosin Mesylate Doxazosin Mesylate是一种α-1肾上腺素能受体抑制剂。	J Clin Invest,2013, 123(12):5119-34 Antiviral Res,2015, 120:140-6 J Ocul Pharmacol Ther,2017, 33(1):50-56
S5703^New	Carvedilol Phosphate Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.
S5723^New	Carvedilol EP IMpurity E Carvedilol is a nonselective beta blocker/alpha-1 blocker and used in management of congestive heart failure (CHF).
S5739^New	Nebivolol Nebivolol is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.
S4076	Propranolol HCl Propranolol HCl是一种竞争性和非选择性β-肾上腺素受体抑制剂，IC50为12 nM.
S1206	Bisoprolol fumarate Bisoprolol fumarate是一种选择性β1型肾上腺素能受体抑制剂。	J Cell Mol Med,2018, 22(12):5964-5977 J Toxicol Sci,2017, 42(6):755-761
S4113	Desvenlafaxine Desvenlafaxine是一种5-羟色胺(5-HT)和去甲肾上腺素(NE)重吸收抑制剂，K_i值分别为40.2 nM和558.4 nM。
S5088	Labetalone hydrochloride Labetalone hydrochloride是labetalone的盐酸盐形式，labetalone是alpha- 和 beta-adrenergic receptors的阻滞剂，被用作一种降压药。
S1642	Methyldopa Methyldopa 是DOPA 脱羧酶竞争性抑制剂，ED50为21.8 mg/kg。
S4112	Desvenlafaxine Succinate Desvenlafaxine Succinate是一种新型5-羟色胺(5-HT)转运蛋白和去甲肾上腺素(NE)转运蛋白重吸收抑制剂，K_i值分别为40.2 nM和558.4 nM
S2086	Ivabradine HCl Ivabradine HCl是一种新型I_f抑制剂，IC50为2.9 μM，特定有效作用于窦房结心脏起搏器活性，是一种纯粹的心跳速率降低剂。
S2113	Cisatracurium Besylate Cisatracurium Besylate是一种非去极化神经肌肉阻断剂，通过抑制神经肌肉的传导而对乙酰胆碱起拮抗作用。

产品目录	产品描述	文献引用	实验数据
S1283	Asenapine maleate Asenapine maleate是一种高亲和性的包括 serotonin, norepinephrine, dopamine 和 histamine receptors在内的多种受体的拮抗剂，用于治疗神经分裂症以及抑郁狂躁型忧郁症。
S6447^New	Carazolol Carazolol是一种非特异性β肾上腺素能阻滞剂。
S5942^New	Bisoprolol Bisoprolol是心脏选择性β1-adrenergic receptor阻滞剂，用于阻止心肌梗死、心力衰竭、心绞痛和轻中度高血压。
S5782^New	Doxazosin Doxazosin是一种喹唑啉衍生物，可选择性拮抗突触后α1肾上腺素能受体（α1-adrenergic receptors）。
S5923^New	Celiprolol hydrochloride Celiprolol是β1-adrenoceptor拮抗剂，具有部分β2受体激动剂活性。
S5778^New	Esmolol Esmolol是心脏选择性β1阻断剂，能迅速发挥作用、持续时间短，在治疗剂量下，对内在拟交感活性或膜稳定性没有显著影响。
S5780^New	Prazosin Prazosin是α1阻断剂，是alpha-1肾上腺素能受体的反向激动剂。
S5766^New	Alfuzosin Alfuzosin是具有选择性的、竞争性α1肾上腺素能受体（α1-adrenoceptor）拮抗剂。
S5802^New	Alprenolol hydrochloride Alprenolol hydrochloride是alprenolol的盐酸盐形式。Alprenolol是beta adrenergic receptor拮抗剂，被用作抗高血压、减轻心绞痛和抗心律失常的试剂。
S5666^New	Moxisylyte hydrochloride Moxisylyte hydrochloride is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease.
S9285^New	Fargesin Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway.
s9050^New	Boldine Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.
S1435^New	Tamsulosin hydrochloride Tamsulosin hydrochloride是一种作用于前列腺的α1A肾上腺素拮抗剂。
S5540^New	Landiolol hydrochloride Landiolol hydrochloride is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist.
S5341^New	Metroprolol succinate Metoprolol Succinate is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity.
S5430^New	Metoprolol Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.
S5281^New	Dapiprazole Hydrochloride Dapiprazole Hydrochloride is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination.
S5432^New	Dibenamine Hydrochloride Dibenamine is an irreversible blocker of α1 adrenoceptors.
S5337^New	Rauwolscine hydrochloride Rauwolscine hydrochloride is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM.
S1409	Alfuzosin HCl Alfuzosin HCl 是一种α1受体拮抗剂，用于治疗良性前列腺增生（BPH）。	Prostate, 2016, 76(8):757-66	PC-3 and LNCaP cell viability following treatment with a1-adrenoceptor antagonists. (A) Cells were treated with drug (0.01-100 μM) for 72 hr and cell viability determined using the resazurin reduction assay. (B) Effect of treatment duration on PC-3 and LNCap cell survival following treatment with doxazosin (30 μM) or prazosin (30 μM). Survival is expressed as the percentage values of untreated vehicle control and values are the mean ( sem) of six independent determinations each conducted in triplicate. P<0.05, **P<0.001 compared to corresponding values for LNCap cells.
S1613	Silodosin Silodosin是一种α1-肾上腺素受体拮抗剂，具有高泌尿选择性。
S1549	Nebivolol HCl 在兔肺β1-肾上腺素受体结合实验中，Nebivolol HCl选择性阻断β1受体，IC50为0.8 nM。
S2691	BMY 7378 Dihydrochloride BMY 7378是一种多靶点抑制剂，作用于α2C-adrenoceptor和α1D-adrenoceptor，pK_i分别为6.54和8.2，且为混合型5-HT1A受体激动剂和拮抗剂，pK_i为8.3。
S1424	Prazosin HCl Prazosin HCl是Quinazoline 衍生物，是一种新型的化学类抗高血压药物。
S2038	Phentolamine Mesylate Phentolamine Mesylate是一种非选择性α-肾上腺素能拮抗剂，IC50为0.1 μM。
S1856	Metoprolol Tartrate Metoprolol Tartrate是一种心脏选择性的β-肾上腺素能受体抑制剂，IC50为42 ng/mL。
S2059	Terazosin HCl Dihydrate Terazosin HCl 是α-肾上腺素能受体抑制剂，用于治疗高血压和前列腺肥大。
S1387	Naftopidil DiHCl Naftopidil DiHCl是一种选择性5-HT1A和α1-adrenergic receptor（α1-肾上腺素受体）拮抗剂，IC50分别为0.1 μM和0.2 μM。
S2517	Maprotiline HCl Maprotiline HCl是一种选择性去甲肾上腺素再摄取抑制剂，也是一种四环类抗抑郁药。
S1831	Carvedilol Carvedilol是一种非选择性β/α-1受体抑制剂，用于治疗充血性心力衰竭和高血压。	Res Pharm Sci, 2015, 10(5):388-96
S2126	Naftopidil Naftopidil 是选择性α1-肾上腺素能受体拮抗剂，或α受体抑制剂，K_i为58.3 nM。
S2499	Phenoxybenzamine HCl Phenoxybenzamine HCl是一种非选择性，不可逆α受体拮抗剂，IC50为550 nM。
S2509	Sotalol HCl Sotalol 是一种非选择性β受体抑制剂，是钾离子通道抑制剂，IC50为43 μM。	Toxicol Appl Pharmacol, 2015, 285(1):51-60 Gynecol Oncol, 2018, 151(3):525-532
S4123	Timolol Maleate Timolol Maleate是一种非选择性的β-肾上腺素能受体拮抗剂，作用于β1/β2，K_i为1.97 nM/2.0 nM。
S4010	Acebutolol HCl Acebutolol HCl是beta-adrenergic receptors（β-肾上腺素能受体）拮抗剂，用于治疗高血压，心绞痛，和心律失常。
S1827	Betaxolol HCl Betaxolol HCl是一种β₁肾上腺素受体阻断剂，IC50是6 Μm。
S2607	Buflomedil HCl Buflomedil HCl是一种血管扩张剂，用于治疗跛行或外周动脉疾病的症状。是一种非选择性alpha adrenergic receptor抑制剂。
S3664	Flupenthixol dihydrochloride Flupentixol是一种抗精神病安定药物，是D1 and D2多巴胺受体的强效拮抗剂，也是α肾上腺素能受体的拮抗剂。
S4124	Tolazoline HCl Tolazoline HCl是一种非选择性和竞争性的α-肾上腺素能受体拮抗剂。	Insect Biochem Mol Biol, 2017, 90:61-70
S4649	Atipamezole hydrochloride Atipamezole是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。Atipamezole hydrochloride是atipamezole的盐酸盐形式。
S4650	Atipamezole Atipamezole是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。
S3656	Piribedil Piribedil is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.
S4679	Terazosin HCl Terazosin是一种选择性的alpha-1拮抗剂，用于治疗前列腺肿大症状。它通过抑制膀胱平滑肌和血管壁上的肾上腺素的作用发挥效应。
S4085	Levobetaxolol HCl Levobetaxolol高亲和力作用于克隆的人β1和β2受体，K_i分别为0.76 nM和32.6 nM。
S5042	Bevantolol hydrochloride Bevantolol hydrochloride选择性β肾上腺素受体拮抗剂，没有β内源性拟交感活性，膜稳定性较弱，具有局部麻醉作用。
S8114	ICI-118551 Hydrochloride ICI-118551是高选择性的β2肾上腺素受体拮抗剂，其对β2,β1和β3 受体的Ki值分别为0.7, 49.5和611 nM。
S4100	Esmolol HCl Esmolol是一种心脏选择性B受体阻滞剂，用于控制心跳急或异常心率节律。
S2091	Betaxolol Betaxolol是一种选择性的β1肾上腺素能受体抑制剂，用于治疗高血压和青光眼。
S4278	Carteolol HCl Carteolol HCl 是一种β-adrenoceptor拮抗剂,用于治疗青光眼。
S4817	Atenolol Atenolol是一种选择性的β1 receptor拮抗剂，对人源β1-, β2- 和β3-肾上腺受体的log Kd值分别为−6.66±0.05, −5.99±0.14, −4.11±0.07。
S2373	Yohimbine HCl Yohimbine HCl 是一种瞳孔放大剂，用于治疗阳痿，也是一种春药。
S4291	Labetalol HCl Labetalol HCl是一种选择性alpha1-adrenergic 和非选择性beta-adrenergic receptors的双重拮抗剂，用于高血压的治疗。

产品目录	产品描述	文献引用	实验数据
S2507	Salbutamol Sulfate Salbutamol Sulfate是一种短效的β2-肾上腺素能受体激动剂，IC50为8.93 µM。	Eur J Immunol, 2016, 1948-58 Sci Rep, 2015, 5:7681	(B) Bar graphs summarize the incidence of VA from Con (An external file that holds a picture, illustration, etc. Object name is srep07681-m1.jpg) and HF (An external file that holds a picture, illustration, etc. Object name is srep07681-m2.jpg) guinea pigs before and after administration of Sal (10 μM) or Sal plus ICI (1 μM) (*p < 0.05, HF + Sal vs. Con + Sal; #p < 0.05, HF + Sal vs. HF + Sal + ICI, n = 6).
S4009	Mirabegron Mirabegron是一种选择性的beta3-adrenoceptor（β3肾上腺素受体）激动剂，EC50为22.4 nM。	Andrologia, 2019, 10.1111/and.13241
S2516	Xylazine HCl Xylazine HCl是一种α2肾上腺素能受体激动剂，用作镇定剂和肌肉松弛剂。	Biomed Rep, 2016, 5(3):357-360 Acad Radiol, 2012, 19(3):358-65 J Neurochem, 2018, 146(6):703-721
S2083^New	Procaterol HCl Procaterol HCl是短效的β2-肾上腺素能受体激动剂，K_p为8 nM，用于治疗哮喘。
S5925^New	Olodaterol hydrochloride Olodaterol hydrochloride是Olodaterol的盐酸盐形式，Olodaterol是一种长效的β2肾上腺素能受体（beta2-adrenergic）激动剂。
S5669^New	Isoxsuprine hydrochloride Isoxsuprine hydrochloride是β-肾上腺素能受体（beta-adrenergic）激动剂，具有血管扩张活性。
S5768^New	Fenoterol hydrobromide Fenoterol hydrobromide是fenoterol的氢溴酸盐。Fenoterol是β2 adrenoreceptor激动剂，具有支气管扩张活性。
S5769^New	Fenoterol Fenoterol是β2 adrenoreceptor激动剂，具有支气管扩张活性。
S5683^New	Isoproterenol sulfate dihydrate Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity.
S5750^New	DL-Norepinephrine hydrochloride Norepinephrine is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors.
S5751^New	Dihydroergotamine Mesylate Dihydroergotamine Mesylate is an ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors.
S9507^New	(−)-Norepinephrine (−)-Norepinephrine是一种天然存在的神经递质和激素。它是adrenergic receptors的激动剂，对α1, α2A和β1肾上腺素受体的Ki值分别为330 nM、56 nM和740 nM。
S9508^New	Brimonidine Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure.
S5564^New	Xylazine Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.
S5727^New	Tetryzoline Tetryzoline is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays.
S5734^New	Midodrine hydrochloride Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor.
S5735^New	Midodrine Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.
S5217^New	Arformoterol Tartrate Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity.
S5654^New	Indacaterol Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.
S5267^New	Nylidrin Hydrochloride Nylidrin Hydrochloride, a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well.
S5537^New	Tizanidine
S5494^New	Salbutamol Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases.
S5527^New	Salmeterol Salmeterol is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).
S3083	Indacaterol Maleate Indacaterol Maleate是一种超长效的β-adrenoceptor激动剂，对β1-adrenoceptor的pK_i为 7.36，对 β2-adrenoceptor 的pK_i为5.48。
S2566	Isoprenaline HCl Isoprenaline是一种非选择性β-肾上腺素能受体激动剂，用于治疗心动过缓和心传导阻滞。
S2020	Formoterol Hemifumarate Formoterol Hemifumarate是一种有效的，选择性的，长效β2-adrenoceptor 激动剂，用于治疗哮喘以及慢性阻塞性肺病。
S2521	Epinephrine bitartrate Epinephrine Bitartrate 是一种α和β-肾上腺素能受体激动剂。
S2458	Clonidine HCl Clonidine HCl 是一种直接起作用的α2肾上腺素能受体激动剂，ED50为0.02±0.01 mg/kg。
S3041	Droxidopa Droxidopa是一种精神药物，是合成的氨基酸前体，它作为神经传导物质去甲肾上腺素和肾上腺素的前药来发挥作用。
S3075	Dexmedetomidine Dexmedetomidine是特护病房和麻醉师使用的一种镇静剂。
S2522	L-Adrenaline L-Adrenaline属于儿茶酚胺类。
S2569	Phenylephrine HCl Phenylephrine HCl是一种选择性的α1-肾上腺素能受体激动剂。	Stem Cells Dev, 2017, 26(7):528-540	(F) Fluo-4 AM-loaded EPLC-SMCs and HCASMCs displayed a change in cell surface area following phenylephrine stimulation. Scale bars, 100 μm. (G) Percentage change in cell surface area. Error bars represent SEM; n = 12 cells; **p < 0.01 versus D15 + 8 + 6 cells that did not exhibit calcium transients, analyzed by the Student's t-test. HCASMCs, human coronary artery smooth muscle cells; NS, no significant difference.
S4065	Guanabenz Acetate Guanabenz Acetate是一种选择性的α2a-肾上腺素能受体， α2b-肾上腺素能受体和α2c-肾上腺素能受体激动剂，pEC50分别为8.25， 7.01和5左右。
S2519	Naphazoline HCl Naphazoline HCl 是一种眼部血管收缩剂，是咪唑啉衍生的拟交感胺类。
S2533	Ritodrine HCl Ritodrine HCl 是Ritodrine的盐酸盐，是β-2肾上腺素能受体激动剂。
S2438	Synephrine HCl Synephrine HCl是一种交感神经α-adrenergic receptor (AR)（肾上腺素受体）激动剂。
S2090	Dexmedetomidine HCl Dexmedetomidine HCl 是一种有效的，高度选择性α-2肾上腺素受体激动剂，具有显著的镇静效果，从而降低患者的麻醉量。
S3061	Epinephrine HCl Epinephrine HCl是一种激素和神经递质。
S3060	Medetomidine HCl Medetomidine HCl是一种选择性的α2-adrenoceptor（α2-肾上腺素受体）激动剂，K_i为1.08 nM，比作用于α1-adrenoceptor选择性高1620倍。	Micromachines, 2018, 9(6)
S1437	Tizanidine HCl Tizanidine HCl是一种α2-肾上腺素受体，抑制中枢神经系统去甲肾上腺素能神经的神经递质的释放。
S2092	Detomidine HCl Detomidine HCl可产生镇静和镇痛作用，这种作用具有剂量依赖性，通过激活α2儿茶酚胺受体来调节。	Nature, 2018, 560(7718):372-376
S2545	Scopine Scopine是Anisodine的代谢产物，是一种α1-肾上腺素能受体激动剂，用于治疗急性循环性休克。
S4296	Salmeterol Xinafoate Salmeterol Xinafoate是一种长效的β2-adrenergic receptor激动剂，具有抗炎作用，用于哮喘症状和慢性阻塞性肺疾病（COPD）症状的治疗。
S2523	DL-Adrenaline DL-Adrenaline是一种激素，是由肾上腺髓质分泌的一种神经递质。
S4266	Brimonidine Tartrate Brimonidine Tartrate是一种高选择性的α-肾上腺素能受体激动剂，EC50为0.45 nM，用于治疗开角型青光眼或高眼压症。
S3960	Higenamine hydrochloride Higenamine, also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.
S2615	Noradrenaline bitartrate monohydrate Noradrenaline bitartrate monohydrate 是一种直接的α-肾上腺素能受体激动剂。
S7974	L755507 L-755,507是一种有效的、选择性的β3肾上腺素能受体部分激动剂，EC50为0.43 nM。它能在iPSCs和其他细胞类型中增强CRISPR介导的同源重组修复效率。
S4127	Terbutaline Sulfate Terbutaline Sulfate是一种选择性的β2-肾上腺素能受体激动剂，IC50为53 nM。
S4135	Clorprenaline HCl Clorprenaline HCl是β2-受体激动剂，具有显著的扩张支气管作用。
S4043	Tetrahydrozoline HCl Tetrahydrozoline HCl是一种咪唑啉衍生物，具有α受体激动剂活性。
S2576	Xylometazoline HCl Xylometazoline HCl 是α-adrenoceptor激动剂，常用作鼻血管收缩药，高效作用于α_2B肾上腺素受体亚型，EC50为4 μM。
S3640	Methoxyphenamine Hydrochloride Methoxyphenamine Hydrochloride is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.
S3643	Amitraz Amitraz是一种α2 肾上腺素能受体激动剂。它是非系统性杀螨剂和杀虫剂。
S3727	Vilanterol Trifenate Vilanterol trifenatate is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma.
S4693	Guanfacine Hydrochloride Guanfacine Hydrochloride是一种选择性的α2A-肾上腺素受体激动剂，具有降压效果。
S4277	Bambuterol HCl Bambuterol HCl是强效β-adrenoceptor拮抗剂，用于治疗哮喘。
S2362	Synephrine Synephrine是从苦橘及其他柑橘属植物中提取的一种不饱和的植物甾醇，常用于减肥。
S3185	Adrenalone HCl Adrenalone HCl是一种肾上腺素激动剂，作为外用的血管收缩剂和止血剂，主要作用于α-1肾上腺素受体。

产品目录	产品描述	文献引用	实验数据
S9560^New	Anisodamine Hydrobromide Anisodamine是天然存在的阿托品（atropine）衍生物，具有消炎活性。它能抑制α1-adrenergic receptors和mAChRs。
S4243	Deoxycorticosterone acetate Deoxycorticosterone acetate是一种类固醇激素，用于肌肉注射，是肾上腺皮质类固醇的代替疗法。

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S9560^New