Navitoclax (ABT-263)

For research use only. Not for use in humans.

目录号:S1001

Navitoclax (ABT-263) Chemical Structure

CAS No. 923564-51-6

Navitoclax (ABT-263)是一种有效的Bcl-xLBcl-2Bcl-w抑制剂,无细胞试验中Ki分别为≤0.5 nM,≤1 nM和≤1 nM,但与Mcl-1和A1结合微弱。Phase 2。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 3285.53 现货
RMB 975.71 现货
RMB 1631.61 现货
RMB 3016.58 现货
RMB 7950.36 现货
有超大折扣

今日订购,明日送达,全国免运费!

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Navitoclax (ABT-263)发表文献201篇:

产品安全说明书

Bcl-2抑制剂选择性比较

生物活性

产品描述 Navitoclax (ABT-263)是一种有效的Bcl-xLBcl-2Bcl-w抑制剂,无细胞试验中Ki分别为≤0.5 nM,≤1 nM和≤1 nM,但与Mcl-1和A1结合微弱。Phase 2。
靶点
Bcl-xL [1]
(Cell-free assay)
Bcl-2 [1]
(Cell-free assay)
Bcl-w [1]
(Cell-free assay)
<=0.5 nM(Ki) <=1 nM(Ki) <=1 nM(Ki)
体外研究

ABT-263有效抑制Bcl-2蛋白家族,用荧光偏振分析法测试ABT-263作用于Bcl-xL, Bcl-2和 Bcl-w时,Ki分别为0.5, 1和1 nM。[1]ABT-263结构上与ABT-737相关。ABT-263阻断Bcl-2 和Bcl-XL与凋亡前体蛋白相互作用。Bcl-2家族成员Bcl-2,Bcl-XL, 和Mcl-1的过量表达通常都与肿瘤的修复及抗药性有关。ABT-263作用于过量表达的Bcl-2 和Bcl-XL时显示出保护作用,EC50分别为60 和20 nM。ABT-263作用于不同的细胞显示出不同的细胞活性,作用于H146细胞系时EC50为110nM,而作用于H82细胞系时EC50为22 µM。ABT-737可以有效作用于四种EC50值 <400 nM的细胞系,即H146, H889, H1963, 和H1417。而两种抗ABT-737的细胞系,即H1048和H82,同样也显示出抗ABT-263的特性。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NXu5XmRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XY[2lEPTB;MD6wNFY3QSEQvF2= NFTSW|hUSU6JRWK=
MV-4-11 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rDbWlEPTB;MD6wNVU5PiEQvF2= NF31PHFUSU6JRWK=
NKM-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfzbYxKSzVyPUCuNFE3QTlizszN MX;TRW5ITVJ?
ML-2 NHe3eHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;KTWM2OD1yLkCxPVg{KM7:TR?= NFXKdXdUSU6JRWK=
BV-173 MkTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PMRWlEPTB;MD6wNlMyPCEQvF2= MlS1V2FPT0WU
RS4-11 NYP4[XdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4npRWlEPTB;MD6wNlU5PyEQvF2= NXPp[nZ5W0GQR1XS
HL-60 NVLy[IpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUj4NXRnUUN3ME2wMlAzQTB6IN88US=> MV3TRW5ITVJ?
KY821 MlTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PpbmlEPTB;MD6wNlk4PSEQvF2= NVHKcodlW0GQR1XS
ECC10 MoW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3UfJpCUUN3ME2wMlA{Pzl{IN88US=> M4GyXnNCVkeHUh?=
NCI-H720 NYToXZR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnpWnZRUUN3ME2wMlA1ODFzIN88US=> Mn2yV2FPT0WU
QIMR-WIL NFLQd5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fZc2lEPTB;MD6wOFI5PyEQvF2= MmD5V2FPT0WU
KG-1 NYPENJdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMES0PFYh|ryP NFPrbpZUSU6JRWK=
TGW M{D5Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEX6Vo1KSzVyPUCuNFQ3OzNizszN M4jMd3NCVkeHUh?=
ATN-1 MoHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMES3N|Mh|ryP NHPScXNUSU6JRWK=
RH-18 M3HnUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTzTG9KSzVyPUCuNFYxPDhizszN M3O5[HNCVkeHUh?=
EW-18 Mon6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;pXFFKSzVyPUCuNFY5PDFizszN NVjQXHhLW0GQR1XS
NB17 NEDrVHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXUXXZKSzVyPUCuNFcyOjRizszN NX7iWWx3W0GQR1XS
SK-NEP-1 MlnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7sWIxRUUN3ME2wMlA4OjF|IN88US=> NGXFeo9USU6JRWK=
P12-ICHIKAWA MonSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMEe3O|gh|ryP M4ryPXNCVkeHUh?=
KARPAS-45 NFPKbXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M373dGlEPTB;MD6wO|gyPSEQvF2= MkD6V2FPT0WU
EW-3 NYf3UXl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIC5cphKSzVyPUCuNFgxPTNizszN MoTwV2FPT0WU
NB13 NVPuWploT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:1OmxKSzVyPUCuNFgzODNizszN NG\jdY9USU6JRWK=
NCI-H209 NF3PSmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\UOGlEPTB;MD6wPFcxPCEQvF2= M4T1VHNCVkeHUh?=
NCI-H1092 NIX3UlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PUOmlEPTB;MD6xNFI4PSEQvF2= NE\sNlNUSU6JRWK=
NH-12 NU[3SYhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnT3TWM2OD1yLkGwO|Q1KM7:TR?= NWPNW49GW0GQR1XS
697 NHHtfWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfKe5NmUUN3ME2wMlExQDN7IN88US=> NITifHlUSU6JRWK=
KE-37 MnHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTF[nQ5UUN3ME2wMlEyOzdizszN NXm1UI16W0GQR1XS
MOLT-4 NVn4OIx4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2X5cmlEPTB;MD6xOVE3QSEQvF2= MUHTRW5ITVJ?
CHP-134 NI\ScHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHMVlA{UUN3ME2wMlE3OzB4IN88US=> NHzzc2xUSU6JRWK=
D-283MED MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMUe2PFYh|ryP Mmj1V2FPT0WU
LU-135 NWn6UY9YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfaTmJKSzVyPUCuNVg2PTJizszN M1f4dXNCVkeHUh?=
LU-134-A NUHuT|JtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDrbHlFUUN3ME2wMlE5PjdzIN88US=> NUDXSXRFW0GQR1XS
EM-2 MnzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMUm5NVgh|ryP NUWwcJdxW0GQR1XS
LU-139 NUXae3NMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDDdopKSzVyPUCuNlA1QThizszN M2LFVXNCVkeHUh?=
ALL-PO MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMkG5PFgh|ryP NFzm[mdUSU6JRWK=
NB12 NX7TS5ZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHX[25KSzVyPUCuNlMyOTVizszN M4PrUnNCVkeHUh?=
KP-N-YN NEjIbZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPvTWM2OD1yLkKzOVc{KM7:TR?= MXLTRW5ITVJ?
BEN NVy4[nhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjHbYlKSzVyPUCuNlM6PjhizszN M3HYPHNCVkeHUh?=
HCC1569 NFfi[JJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3sTWM2OD1yLkK1NVA3KM7:TR?= M4PqfXNCVkeHUh?=
HuO9 NEKyW3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXGemlKSzVyPUCuNlY4OTVizszN M3TFZnNCVkeHUh?=
WM-115 Ml3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMke3N|gh|ryP NH20WZJUSU6JRWK=
CCRF-CEM M2PxNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jCWGlEPTB;MD6zN|UzQSEQvF2= NX64V2lEW0GQR1XS
IST-SL1 M3ntNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwM{WzOFMh|ryP MXrTRW5ITVJ?
BE-13 MmixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwM{[0OVkh|ryP MkfpV2FPT0WU
COR-L88 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwM{[1OEDPxE1? NGi0O41USU6JRWK=
DOHH-2 NXXSSXlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\UTWM2OD1yLkSxNFI{KM7:TR?= M17MPHNCVkeHUh?=
A704 MoHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTyeXZTUUN3ME2wMlQzPjdizszN MWfTRW5ITVJ?
KNS-81-FD M13zTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwNESwNVch|ryP Mm\DV2FPT0WU
RPMI-8226 NGnQfHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwNEW2OVIh|ryP M2HvT3NCVkeHUh?=
TGBC24TKB M3rI[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3SzVmlEPTB;MD60OVc4QCEQvF2= MkjiV2FPT0WU
NCI-H1304 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwNE[xOVch|ryP NGq5RW1USU6JRWK=
MOLT-13 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwNE[2NVMh|ryP NWLWRmVZW0GQR1XS
EW-22 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfuTWM2OD1yLkS2OlcyKM7:TR?= MULTRW5ITVJ?
MS-1 M{ixWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rpNWlEPTB;MD60Olk{OyEQvF2= MX;TRW5ITVJ?
RMG-I M4[4[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjYWHR5UUN3ME2wMlQ6PDZ2IN88US=> M3W5WHNCVkeHUh?=
NTERA-S-cl-D1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwNUCwNVkh|ryP NVrTdplVW0GQR1XS
NCI-H1048 Mlv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwNUC5OVMh|ryP MnTSV2FPT0WU
SW1417 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILHUFBKSzVyPUCuOVU1OzhizszN MUnTRW5ITVJ?
DB M4TRVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGD5VlhKSzVyPUCuOVcxQCEQvF2= MXTTRW5ITVJ?
MEG-01 NGnndXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;oSndKUUN3ME2wMlU5OzJizszN NIL6bWFUSU6JRWK=
EW-13 Mkn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4j4N2lEPTB;MD61PFM1OSEQvF2= NFOxT3pUSU6JRWK=
LAMA-84 NWfw[ZVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwNUmyNFch|ryP NYq3XWhLW0GQR1XS
J-RT3-T3-5 NWS5ZW1FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHn6eYhKSzVyPUCuOlA5ODhizszN M37kbnNCVkeHUh?=
MOLT-16 NHrSV4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\tTWM2OD1yLk[1NlY1KM7:TR?= NVLKPFFVW0GQR1XS
DU-4475 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwNkW0Nlch|ryP Mkf3V2FPT0WU
HAL-01 NFH6NnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTxTWM2OD1yLkeyOVQ6KM7:TR?= NGfCfVlUSU6JRWK=
RD MnzoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlGyTWM2OD1yLke1PFk6KM7:TR?= MXTTRW5ITVJ?
OAW-28 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwN{izO{DPxE1? MVHTRW5ITVJ?
HCC38 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTTdGRTUUN3ME2wMlgxOTlizszN NHP4e3JUSU6JRWK=
NMC-G1 NFL0RWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTt[|JKSzVyPUCuPFEyOjFizszN M3LnPHNCVkeHUh?=
EW-16 M1rpb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3viSmlEPTB;MD64NVMzQCEQvF2= NV;5PXRkW0GQR1XS
DU-145 NWj6RYN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUD2eIF4UUN3ME2wMlg6QTJ|IN88US=> MWrTRW5ITVJ?
HPAF-II Ml2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwOUK2Nlgh|ryP NGHPO|hUSU6JRWK=
A427 M{fpdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTkdFRKSzVyPUCuPVMxOjJizszN MV7TRW5ITVJ?
PA-1 MmPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXxPVJKSzVyPUCuPVU3PDJizszN NHize5JUSU6JRWK=
OAW-42 M1PRcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\EUmlEPTB;MD65OlE1PiEQvF2= NXHlenZWW0GQR1XS
L-428 M1rwdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmT1TWM2OD1zLkCxNlUh|ryP MnnvV2FPT0WU
COLO-824 NEHpTYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTFwMEG3NFgh|ryP MYLTRW5ITVJ?
P30-OHK NW\YdYM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1L3fGlEPTB;MT6wOFY5QCEQvF2= M3z4XXNCVkeHUh?=
NCI-H2170 NEfwdmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTFwME[yN{DPxE1? NV7mOFRjW0GQR1XS
HCC2998 Mm\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlziTWM2OD1zLkC3NVM2KM7:TR?= NWjITo9FW0GQR1XS
NB14 M{LaW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTFwMUO3OFgh|ryP MoHKV2FPT0WU
TGBC1TKB MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fnc2lEPTB;MT6xOFE2OiEQvF2= MUfTRW5ITVJ?
KP-N-YS MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTyTWM2OD1zLkG2NlM3KM7:TR?= Moe3V2FPT0WU
CAL-120 M2ey[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHKTWM2OD1zLkG2OFI6KM7:TR?= NF36dFNUSU6JRWK=
SBC-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LkVGlEPTB;MT6xPVA2OyEQvF2= NYLrdmU{W0GQR1XS
C32 M{jHfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmn0TWM2OD1zLkG5NFg5KM7:TR?= MU\TRW5ITVJ?
HCC2157 M2jK[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXPZXNlUUN3ME2xMlE6PDl2IN88US=> NH7WVZVUSU6JRWK=
COLO-792 NITG[5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjIO49vUUN3ME2xMlIxODdzIN88US=> NITN[JhUSU6JRWK=
ES7 MoW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1j6eWlEPTB;MT6yO|k2OSEQvF2= MnvXV2FPT0WU
HEL NHHzVW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Pxb2lEPTB;MT6zNVAzQSEQvF2= MlfLV2FPT0WU
ES4 M3HRfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDk[Y9KSzVyPUGuN|Q6QThizszN M{[0dXNCVkeHUh?=
NCI-SNU-1 MmXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnteoVTUUN3ME2xMlM3PTV3IN88US=> M1HhXHNCVkeHUh?=
MDA-MB-415 M2LDXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnq3TWM2OD1zLkO4PFUh|ryP MVfTRW5ITVJ?
NCI-H2342 M3vuOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVSz[JdYUUN3ME2xMlQxOjZ7IN88US=> MWrTRW5ITVJ?
NB69 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonhTWM2OD1zLkS2NlcyKM7:TR?= Mn7qV2FPT0WU
D-247MG NV3FOXI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlK0TWM2OD1zLkWxNVIzKM7:TR?= NYDJNG12W0GQR1XS
SCC-4 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTpTWM2OD1zLkW5PFg4KM7:TR?= Mn3iV2FPT0WU
HuH-7 M1f0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTFwNkeyPVMh|ryP M3P1WXNCVkeHUh?=
A388 NWLndG1tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrUTWM2OD1zLk[4O|I1KM7:TR?= MmLvV2FPT0WU
Calu-3 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;4SlZKSzVyPUGuO|A3QTdizszN M1f2U3NCVkeHUh?=
NCI-H1648 MlOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTxXnFKSzVyPUGuO|E1OThizszN NV7jdVJLW0GQR1XS
NCI-H2052 MmPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTFwN{KyNFEh|ryP NXT1[2lZW0GQR1XS
Ramos-2G6-4C10 MoDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;k[HltUUN3ME2xMlc{PjV4IN88US=> NIL6VWNUSU6JRWK=
DEL MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTFwN{S2PVIh|ryP NYG4VGViW0GQR1XS
SNU-423 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTFwN{ixOVch|ryP M4jld3NCVkeHUh?=
COR-L23 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTFwN{m4O|Qh|ryP MmDsV2FPT0WU
OMC-1 NFzOSWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPWT4I{UUN3ME2xMlg3ODF4IN88US=> MkD3V2FPT0WU
EW-11 NV62PFJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTFwOUW2OVch|ryP MUTTRW5ITVJ?
HSC-3 NV:2cotTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULufIZ{UUN3ME2xMlk3OzZ3IN88US=> NVP6ZWxDW0GQR1XS
MLMA MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4H2U2lEPTB;MT65OlY4PyEQvF2= NH35U2ZUSU6JRWK=
RCM-1 NHHTeIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITYWWtKSzVyPUKuNFA{QTlizszN M3n2UnNCVkeHUh?=
MFE-280 NUDRfmdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4G0O2lEPTB;Mj6wNlg1QCEQvF2= M{Dae3NCVkeHUh?=
ES8 NVS2VFdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLte45KSzVyPUKuNlU1PzFizszN M4LHSHNCVkeHUh?=
TE-11 NFPNUVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJwMkm0O|Mh|ryP MXXTRW5ITVJ?
HuO-3N1 MmHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4ewUGlEPTB;Mj60PFc5KM7:TR?= NU\l[WFIW0GQR1XS
MHH-NB-11 NG\HVmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnHWHBKSzVyPUKuOVEyPThizszN Mn3vV2FPT0WU
TGBC11TKB NIrEXXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7qO|hVUUN3ME2yMlU4PjhzIN88US=> MV3TRW5ITVJ?
HOP-92 NGr3cZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\wOWlEPTB;Mj61PFc1OyEQvF2= NXn6TXQ2W0GQR1XS
IGR-1 NGjEV3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jNUmlEPTB;Mj62NlA{PSEQvF2= NIO1UmpUSU6JRWK=
GOTO Mof6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV2zR5YyUUN3ME2yMlY2Ozd5IN88US=> NXHET5NiW0GQR1XS
NCI-H1650 NF7hXI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTJwN{KyNVUh|ryP NHTKe5hUSU6JRWK=
NCI-H1581 MnXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTJwN{m2PFEh|ryP Mn6wV2FPT0WU
NCI-H2405 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\DTWM2OD1{LkiyO|gzKM7:TR?= NInDUZRUSU6JRWK=
U-118-MG MnPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHzd5JKSzVyPUKuPVY1QTFizszN Ml3qV2FPT0WU
DoTc2-4510 M4q1bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETqNnhKSzVyPUOuNFE1OTdizszN MnT3V2FPT0WU
NCI-H596 MoezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEKwe4JKSzVyPUOuNFQ6QTdizszN M4fyd3NCVkeHUh?=
MPP-89 Mn22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnnOlZKSzVyPUOuNFU3PjZizszN MVPTRW5ITVJ?
GCIY MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTNwMkC0PVEh|ryP MVfTRW5ITVJ?
SW626 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXYOohMUUN3ME2zMlI1PTR|IN88US=> MVPTRW5ITVJ?
OCI-AML2 Ml[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3O[pNKSzVyPUOuN|EzPzJizszN Mo\RV2FPT0WU
NBsusSR MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLaTWM2OD1|LkO0PVM5KM7:TR?= MnjBV2FPT0WU
AN3-CA M{XhS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUD5bVlvUUN3ME2zMlQ1OjN6IN88US=> MkHQV2FPT0WU
EFM-19 NGrhRnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PqSGlEPTB;Mz60PFM{QSEQvF2= NWXwNXVUW0GQR1XS
RVH-421 NFzPfYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnWyTWM2OD1|LkW2PFc4KM7:TR?= MmfnV2FPT0WU
5637 NXS3Uo9NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXf0VpY6UUN3ME2zMlYyOTB|IN88US=> NF;oO3VUSU6JRWK=
PANC-08-13 NFH1eYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1faNmlEPTB;Mz62N|Q4OiEQvF2= M3vyTXNCVkeHUh?=
H9 MlfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3n3bmlEPTB;Mz62O|E1PCEQvF2= NUnYeolLW0GQR1XS
KARPAS-299 Ml7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHBXWJKSzVyPUOuOlc{PjFizszN Mo\hV2FPT0WU
TE-5 NVPXV4xsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTNwN{C3NFkh|ryP NHPFfnhUSU6JRWK=
NOS-1 MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTLO2VKSzVyPUOuO|k5OzRizszN MVHTRW5ITVJ?
HH NUXURoEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUe4[lVZUUN3ME2zMlg{QDZ6IN88US=> Mn7CV2FPT0WU
769-P MkjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTNwOEm1NUDPxE1? MVnTRW5ITVJ?
CHP-212 NVWyd5BJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTNwOUK1OFkh|ryP MVvTRW5ITVJ?
NCI-H82 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnTUZRKSzVyPUOuPVU6OzZizszN MkLoV2FPT0WU
Mo-T MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HQSWlEPTB;ND6wOFMyOiEQvF2= MoTxV2FPT0WU
BB65-RCC M4TG[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnMOZdKSzVyPUSuNFQ{QTlizszN M2\rcHNCVkeHUh?=
SW1990 M3PlV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrjdmVSUUN3ME20MlA2QTB6IN88US=> MmLBV2FPT0WU
LK-2 NEHXT29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3v1PWlEPTB;ND6xNVI6OyEQvF2= NUP6OIpOW0GQR1XS
ES5 NIDrPHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjPTWM2OD12LkGzPVg2KM7:TR?= MWDTRW5ITVJ?
JVM-3 NVLlTWVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnn[HV5UUN3ME20MlE5OjJ{IN88US=> MULTRW5ITVJ?
RPMI-7951 NYrC[mdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTRwMkK0NVMh|ryP M3HkU3NCVkeHUh?=
Calu-6 MnSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXaTWM2OD12LkK3PFgyKM7:TR?= NF60UFRUSU6JRWK=
LC-2-ad MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;RN4ZKSzVyPUSuNlk2PjhizszN NV;yU|U{W0GQR1XS
SW954 MoXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1u3bWlEPTB;ND6yPVY3KM7:TR?= NUfHXIVjW0GQR1XS
H-EMC-SS NVTL[mdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHYeYRmUUN3ME20MlMyQDNzIN88US=> NFn1VmdUSU6JRWK=
ES3 NUjwUWVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTRwM{W0OFEh|ryP MX;TRW5ITVJ?
no-11 Ml;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\rRm5bUUN3ME20MlM2PTV2IN88US=> MXvTRW5ITVJ?
LAN-6 NHnre4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3H6N2lEPTB;ND60OVE5QSEQvF2= NIXSeWZUSU6JRWK=
FTC-133 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnyzTWM2OD12LkWzPVUh|ryP MYnTRW5ITVJ?
8505C MmDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVf4Z21sUUN3ME20MlU1OjNizszN MYnTRW5ITVJ?
SW620 MorDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XUcmlEPTB;ND61O|A2PyEQvF2= M3;leXNCVkeHUh?=
BCPAP MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXK0[I4yUUN3ME20MlY{PDhzIN88US=> NHzaN3RUSU6JRWK=
SK-LU-1 M4f4VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTRwNk[wPFkh|ryP Mo\iV2FPT0WU
NCI-H1623 NH\EOndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnpVGFKSzVyPUSuO|AzOjhizszN NVfS[ZhIW0GQR1XS
C2BBe1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37CWmlEPTB;ND63OFAxQCEQvF2= MWXTRW5ITVJ?
GP5d NXLDeIw2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnuTWM2OD12Lke4N|g5KM7:TR?= Mm\RV2FPT0WU
NB6 MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTaTWM2OD12Lki2NlA1KM7:TR?= M3TDPXNCVkeHUh?=
MDA-MB-157 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjtOllKSzVyPUSuPFg4PiEQvF2= NGTzSJNUSU6JRWK=
UMC-11 NGn6blVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jPTmlEPTB;ND64PFk3PCEQvF2= MnLJV2FPT0WU
HCC1419 NXvTXmtqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;obpBKSzVyPUSuPVAxPjNizszN NXfnTlRkW0GQR1XS
NCI-H2029 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moj2TWM2OD12Lkm0NVg2KM7:TR?= NIXYWWxUSU6JRWK=
LXF-289 M1rvdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfvOoVKSzVyPUWuNFM4OTlizszN MkK1V2FPT0WU
KINGS-1 NVfaZZFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlSyTWM2OD13LkC3O|Q1KM7:TR?= NELBd45USU6JRWK=
HD-MY-Z MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoezTWM2OD13LkKzPVY6KM7:TR?= MWTTRW5ITVJ?
ESS-1 M4H5WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XSWGlEPTB;NT6yOVU6PyEQvF2= MYnTRW5ITVJ?
GI-1 NULi[WZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnyxTWM2OD13LkK3PVI3KM7:TR?= NYK0N5ZTW0GQR1XS
RPMI-2650 NH63PYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nJbWlEPTB;NT6zOlE3KM7:TR?= MXzTRW5ITVJ?
IA-LM MkTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4S5SmlEPTB;NT6zPVg4OSEQvF2= NU\RR5lXW0GQR1XS
KP-4 MnrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXZTWM2OD13LkS2N|M1KM7:TR?= MUfTRW5ITVJ?
G-402 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI[3Z2tKSzVyPUWuOVE5PjVizszN MX\TRW5ITVJ?
OS-RC-2 NYP2[|NqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;sTWM2OD13LkWyOlA1KM7:TR?= MkG5V2FPT0WU
NCI-H1155 NXrBOmczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\H[|ZKSzVyPUWuOVQ6PTVizszN MXLTRW5ITVJ?
OE19 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTVwNki2NlQh|ryP NVfh[2lJW0GQR1XS
U-2-OS MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX63cZd1UUN3ME21Mlg6ODF|IN88US=> NXP2O|ZEW0GQR1XS
SCC-15 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTVwOUO2OlIh|ryP NF\nO5JUSU6JRWK=
NCI-H630 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2P0emlEPTB;NT65PVQxPCEQvF2= NHvkemNUSU6JRWK=
PFSK-1 NVHOc49LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvuTWM2OD14LkC1NlU6KM7:TR?= NYnUNlhuW0GQR1XS
NCI-H1770 NIfLc5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTZwMkC4O|Qh|ryP NXLZWW5lW0GQR1XS
SK-MEL-3 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjITWM2OD14LkSyPVE2KM7:TR?= M4DwRnNCVkeHUh?=
LB1047-RCC NYnQcHU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nScWlEPTB;Nj60O|YzPSEQvF2= M1npcXNCVkeHUh?=
NCI-H446 NI\qPFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofLTWM2OD14Lk[yPVI2KM7:TR?= NI\Eb2NUSU6JRWK=
SW780 NEHnT29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTZwN{CxPFUh|ryP M1;lbnNCVkeHUh?=
NEC8 NGT5d2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;ucZJsUUN3ME22Mlc3PjNizszN NFnUVIZUSU6JRWK=
NOMO-1 NX;jepBIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTZwN{ixNVEh|ryP M2HMWnNCVkeHUh?=
COLO-668 M4HQcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnnc5FKSzVyPU[uPFQ{QDdizszN NWTQPYNRW0GQR1XS
MC116 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTSeZBCUUN3ME22Mlk{QDl5IN88US=> M1fXWXNCVkeHUh?=
HCC1937 NIrmc3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LxXmlEPTB;Nj65PVI2OSEQvF2= NVXaS21DW0GQR1XS
NCI-N87 NXnNNpBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTdwMUmyPVMh|ryP NV30Om5DW0GQR1XS
COLO-320-HSR M{W4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXBNXRKSzVyPUeuNlI4OzhizszN NEi0R4NUSU6JRWK=
HCC1806 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\MUot3UUN3ME23MlI3ODR2IN88US=> MVPTRW5ITVJ?
OVCAR-3 NXTlWWw1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jCc2lEPTB;Nz6zN|A{QCEQvF2= M{n3WnNCVkeHUh?=
NUGC-3 M2DUNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPHb|AyUUN3ME23MlM6Pjl2IN88US=> NEfMU3lUSU6JRWK=
SW1783 NHjzU5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlL6TWM2OD15LkSzNVc2KM7:TR?= MUnTRW5ITVJ?
GCT NIO3SFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTdwNU[5NFYh|ryP M1TCWHNCVkeHUh?=
NCI-H2126 NUTxcZpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYCxdplUUUN3ME23Mlc{PjJ3IN88US=> NVnoSGw4W0GQR1XS
MEL-HO NITaXZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLpTWM2OD15Lke3NFU1KM7:TR?= Mo\pV2FPT0WU
CAPAN-1 NU\UdVdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DxNmlEPTB;Nz63O|M2PyEQvF2= NGrwRXBUSU6JRWK=
SW756 NUHDS5VWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fUbGlEPTB;Nz63PFM{OyEQvF2= NH7OXnFUSU6JRWK=
SKG-IIIa MnLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWm3UJFbUUN3ME23MlgyQDl{IN88US=> MWHTRW5ITVJ?
HCE-T MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDBTWM2OD15Lki3O|g{KM7:TR?= M3PiNnNCVkeHUh?=
Ca-Ski NUHFUnZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrxUWExUUN3ME23Mlk6Ozh|IN88US=> M33MXnNCVkeHUh?=
COLO-684 NWPh[ldRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHMV4xWUUN3ME24MlAyQDF6IN88US=> M1PDOXNCVkeHUh?=
KYSE-70 NHHaUJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4G2W2lEPTB;OD6wO|czQSEQvF2= MnLBV2FPT0WU
TI-73 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILPT2dKSzVyPUiuNlU5PTFizszN NEXCRnJUSU6JRWK=
BT-20 NXX0[HM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLxTWM2OD16LkK2NFUzKM7:TR?= NVjDVG1nW0GQR1XS
MHH-ES-1 NFjMe4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInjUnhKSzVyPUiuOVE5OzRizszN MULTRW5ITVJ?
TE-12 MnvTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlf1TWM2OD16LkW5PVMyKM7:TR?= MX3TRW5ITVJ?
YH-13 M4rCNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTpcoloUUN3ME24MlYyODB6IN88US=> MojsV2FPT0WU
SF126 NHTPXmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRThwOEO4OlUh|ryP NHLJ[|lUSU6JRWK=
J82 NITJdo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17oNmlEPTB;OD65NFA{QCEQvF2= MorkV2FPT0WU
RCC10RGB NXn0OHVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUT4dJoyUUN3ME24Mlk6PTZzIN88US=> M2nkV3NCVkeHUh?=
SK-UT-1 NH7JeINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13uZ2lEPTB;OT6wOFk1PSEQvF2= Mm\MV2FPT0WU
LB2241-RCC NVHVPWF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTlwMUmxN|ch|ryP M2G0NnNCVkeHUh?=
LB996-RCC NGHucodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDmb4JJUUN3ME25MlE6QDlizszN M2HQe3NCVkeHUh?=
EPLC-272H MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELEZ3FKSzVyPUmuN|c3PTdizszN MoTTV2FPT0WU
CTV-1 NXzNV5dOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3SxOGlEPTB;OT61OlU{OiEQvF2= M{noTnNCVkeHUh?=
HSC-2 NGXZc3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXNWGtKSzVyPUmuOVc2PSEQvF2= Mm\tV2FPT0WU
SK-MEL-28 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHqNYN2UUN3ME25MlYyQDl|IN88US=> MlG3V2FPT0WU
MMAC-SF M{LmNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rBWGlEPTB;OT62PFc2KM7:TR?= M4LkTnNCVkeHUh?=
CP50-MEL-B MkH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfLTWM2OD17Lke1O|gzKM7:TR?= M3i3XXNCVkeHUh?=
HT-1080 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTlwN{e3N|kh|ryP NYLPUnRIW0GQR1XS
HEC-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfYTWM2OD1zMD6zN|UzKM7:TR?= NHLQbZlUSU6JRWK=
AGS MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1T5SWlEPTB;MUCuN|c1KM7:TR?= NVrpbo9LW0GQR1XS
GAMG NE[3dGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYi4fVREUUN3ME2xNE42OTZ{IN88US=> NXHzO3B1W0GQR1XS
SW48 M1;JWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37Jc2lEPTB;MUCuOVE5QSEQvF2= M2S5dnNCVkeHUh?=
U031 M3y1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTFyLkW5NFgh|ryP NV;uXIduW0GQR1XS
OVCAR-5 MkLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nDSGlEPTB;MUCuOlQzQSEQvF2= NVHoSYZOW0GQR1XS
SF295 Mm\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzO[G9EUUN3ME2xNE43PzB2IN88US=> NIq3R3FUSU6JRWK=
BHT-101 M4GyO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{j3WGlEPTB;MUCuO|E4PyEQvF2= NXXY[XJ4W0GQR1XS
VMRC-RCZ MmXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\GTWM2OD1zMT6zNlAyKM7:TR?= MmjkV2FPT0WU
ACHN M2rQb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\1ZWlEPTB;MUGuOFIyOSEQvF2= MV\TRW5ITVJ?
NCI-H526 NIm5TXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTFzLkWwOFMh|ryP M3P0c3NCVkeHUh?=
MN-60 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTFzLkWzPUDPxE1? M4Hvb3NCVkeHUh?=
NCI-H2291 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTFzLkW0OlYh|ryP MoXaV2FPT0WU
SCC-25 Mlu5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTFzLke1OVYh|ryP MoW4V2FPT0WU
SK-MEL-2 NY\NVFBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fhT2lEPTB;MUGuO|Y{PyEQvF2= MWXTRW5ITVJ?
SN12C NIDM[3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF61NFdKSzVyPUGxMlk{PTVizszN MmfpV2FPT0WU
NCI-H69 NXP1fYFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXqbHVlUUN3ME2xNk41OjN2IN88US=> M2fLcXNCVkeHUh?=
ME-180 M3Oxdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTF{LkewOVQh|ryP MVLTRW5ITVJ?
MC-IXC M4T5d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTF{Lke1NVgh|ryP NVT5NXBEW0GQR1XS
NCI-H2347 M1vIUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;qSolKSzVyPUGyMlc3OTRizszN M3Ta[HNCVkeHUh?=
M059J M1nKXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TaVWlEPTB;MUKuO|czPyEQvF2= NVraSFdnW0GQR1XS
A2058 Ml3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPOTWM2OD1zMj64OlgyKM7:TR?= NEHweI1USU6JRWK=
VA-ES-BJ MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTF{Lki3PFUh|ryP NYrvfHRrW0GQR1XS
Ca9-22 NH;uNYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTF{Lkm0OVEh|ryP NIH0S4dUSU6JRWK=
KNS-42 M13hcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\ofGlEPTB;MUKuPVk5PCEQvF2= MlLuV2FPT0WU
LoVo MoPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfUcpFKSzVyPUGzMlI{OTNizszN M3;3cnNCVkeHUh?=
AM-38 NV7lOldVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjkTIRKSzVyPUGzMlI2PjZizszN NHjsV5pUSU6JRWK=
NB5 NHWxeplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTF|LkO3OVIh|ryP NVTT[oFQW0GQR1XS
L-363 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTF|LkSwN|Mh|ryP MVrTRW5ITVJ?
SK-MEL-30 MnvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnG0TWM2OD1zND6wOlQ2KM7:TR?= MXjTRW5ITVJ?
NCI-H1563 NVzkWmpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYq5XpBZUUN3ME2xOE43ODN7IN88US=> NI[wdZNUSU6JRWK=
NCI-H2228 NI\iU4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWW0eG5jUUN3ME2xOE43ODd5IN88US=> NEfEbnlUSU6JRWK=
MFM-223 MlnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUD1d5c2UUN3ME2xOU4yQDF|IN88US=> MYTTRW5ITVJ?
LB831-BLC MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTF3LkK3Olch|ryP MXnTRW5ITVJ?
SW872 NInlWGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PkPGlEPTB;MUWuN|A5PiEQvF2= NUj5[m17W0GQR1XS
NCI-H522 NWixXVN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXQS4tsUUN3ME2xOU4{OzB4IN88US=> NYm1UZR4W0GQR1XS
EW-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrUNXFKSzVyPUG1MlU1PjJizszN MV3TRW5ITVJ?
HN M2XuWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nmd2lEPTB;MUWuOVk1OiEQvF2= NVL6c4N3W0GQR1XS
SW837 MlHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PoWGlEPTB;MUWuO|g1PyEQvF2= MmnlV2FPT0WU
SCC-9 MoP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[0NGlEPTB;MUWuPFEyPCEQvF2= M1L4ZnNCVkeHUh?=
MKN7 M{WyU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Xa[WlEPTB;MUWuPVc{OiEQvF2= M4XvZnNCVkeHUh?=
KYSE-410 NEfreXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITHTYZKSzVyPUG2MlU6OSEQvF2= MULTRW5ITVJ?
SK-N-DZ MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTF4Lk[xNVYh|ryP MlvBV2FPT0WU
COR-L105 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvHVVF1UUN3ME2xOk43PTJ6IN88US=> M{fkTnNCVkeHUh?=
LB2518-MEL MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojZTWM2OD1zNj64N|g6KM7:TR?= MUPTRW5ITVJ?
OVCAR-4 NVrsZpN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Lpc2lEPTB;MU[uPFg3OiEQvF2= M2LydHNCVkeHUh?=
TK10 NYTGc2F[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTF4Lkm0O|Mh|ryP NYHqWWJ1W0GQR1XS
KNS-62 NWjONnBLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fnZWlEPTB;MU[uPVc4PyEQvF2= MWLTRW5ITVJ?
RPMI-8866 MlSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13aWmlEPTB;MUeuNVc{OiEQvF2= MX;TRW5ITVJ?
HuP-T4 NFzhRXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnEZldKSzVyPUG3MlI1QTVizszN NWTOTJhKW0GQR1XS
CGTH-W-1 Mn7QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrpNYxKSzVyPUG3MlUzOTlizszN MkDSV2FPT0WU
T-24 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7S[opKSzVyPUG3MlU{PDdizszN NHz4ZWJUSU6JRWK=
HT-3 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{POW2lEPTB;MUeuOVkyPCEQvF2= NYfUV2VRW0GQR1XS
KS-1 MoHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIG1XmxKSzVyPUG3MlY4OyEQvF2= M4\aTnNCVkeHUh?=
NCI-H1792 MkjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHZTWM2OD1zNz63PVgh|ryP MVTTRW5ITVJ?
ABC-1 NFqyU3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnWbJI6UUN3ME2xO{45OTRzIN88US=> M1PXcXNCVkeHUh?=
BPH-1 NXrNRpB{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHuOZZKSzVyPUG4MlE3QDVizszN MWjTRW5ITVJ?
A431 NXPMO2I5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PKemlEPTB;MUiuOFEzPyEQvF2= MkXwV2FPT0WU
T98G NHXmVHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\UTWM2OD1zOD61NVU4KM7:TR?= M{HVenNCVkeHUh?=
BHY MnjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTVR2tKSzVyPUG4Mlg3QSEQvF2= NV7qfWk{W0GQR1XS
Capan-2 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVf6dlVEUUN3ME2xPE46ODd6IN88US=> NIL6fJVUSU6JRWK=
MDA-MB-175-VII M1HUWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfNSFlLUUN3ME2xPE46OjB7IN88US=> M3PvUXNCVkeHUh?=
CAL-27 NIXMTo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzFS5lVUUN3ME2xPU4xPDh5IN88US=> NGLMS|RUSU6JRWK=
AsPC-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGi4eVlKSzVyPUG5Mlg3PTdizszN MX;TRW5ITVJ?
KU812 NWT4W29LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHO5b5dKSzVyPUG5Mlk2PzNizszN M4\ufHNCVkeHUh?=
NCI-H441 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HNfWlEPTB;MkCuNFAyKM7:TR?= NF3hR41USU6JRWK=
Mewo M4T4TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrofGhWUUN3ME2yNE4yOjh6IN88US=> M2fLN3NCVkeHUh?=
SK-MEL-24 NFLsc3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rGN2lEPTB;MkCuNVQ4PyEQvF2= MXLTRW5ITVJ?
NCI-H727 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vtZ2lEPTB;MkCuNlcxPCEQvF2= NHr3VHJUSU6JRWK=
EKVX MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTJyLk[wOkDPxE1? Mmf2V2FPT0WU
RT-112 NFTsbIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTWPJZKSzVyPUKwMlYyOjJizszN MV;TRW5ITVJ?
CAMA-1 M3XZOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV2xNIRuUUN3ME2yNE46QDB|IN88US=> MWTTRW5ITVJ?
SW900 NXjVNXNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnDTWM2OD1{MT6wNVQ6KM7:TR?= NFHsXJNUSU6JRWK=
NCI-H23 M2SycGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTJzLkGyO|ch|ryP MYXTRW5ITVJ?
SK-PN-DW MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzl[4c6UUN3ME2yNU4yPjR7IN88US=> M4m2UXNCVkeHUh?=
BB30-HNC M{jwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknVTWM2OD1{MT6yO|Q2KM7:TR?= MnXhV2FPT0WU
VM-CUB-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jDOGlEPTB;MkGuN|U{PiEQvF2= M4PwdnNCVkeHUh?=
IST-MEL1 NUnpeWp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJzLkO2PVIh|ryP MlfoV2FPT0WU
CTB-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTJzLkS3OVUh|ryP MmHBV2FPT0WU
LCLC-103H M2LWeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHPcmlKSzVyPUKyMlE2QDJizszN NFvje5JUSU6JRWK=
PANC-03-27 NXfQSJpnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTJ{LkWxOlkh|ryP MUTTRW5ITVJ?
HTC-C3 NX:0cHpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPuSHFRUUN3ME2yNk42PTV3IN88US=> M4TKR3NCVkeHUh?=
TE-8 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTJ|LkK1OlUh|ryP MmjPV2FPT0WU
NCI-H292 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTJ3LkO1N|Yh|ryP NUG2T|JNW0GQR1XS
COLO-680N NYKxcYM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIm1fHBKSzVyPUK1MlY{OjlizszN NEXCNo9USU6JRWK=
KYSE-520 Mn3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\ITWM2OD1{NT62OFQh|ryP M17oNHNCVkeHUh?=
NB10 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\wR49KSzVyPUK2MlMyOTdizszN MoTLV2FPT0WU
NCI-H661 MmjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7UTWM2OD1{Nj60O|E{KM7:TR?= NH7xT5JUSU6JRWK=
GMS-10 NH[yUmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnCcIpKSzVyPUK2Mlg3OzhizszN MWrTRW5ITVJ?
NCI-H2122 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTKTWM2OD1{Nj65PVk5KM7:TR?= MoLQV2FPT0WU
OVCAR-8 Mke3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjJR5dKSzVyPUK3MlA3OzhizszN MmrOV2FPT0WU
DJM-1 MmDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrLTWM2OD1{Nz6xOFU1KM7:TR?= MXHTRW5ITVJ?
UACC-893 NHfYN4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJ5Lkm4O|gh|ryP M4e5VnNCVkeHUh?=
C8166 M1fTNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTJ6Lk[5N|gh|ryP MUXTRW5ITVJ?
NCI-H1693 M2[wZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjvTWM2OD1{OD62PVc2KM7:TR?= Mk[1V2FPT0WU
TYK-nu NHjoV49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTNyLkCzOFUh|ryP Mkj2V2FPT0WU
SW1710 Mn7US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHPTWM2OD1|MD6xNlYh|ryP MofkV2FPT0WU
A375 NXrpbm5XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTNyLkOyOFMh|ryP M12ybHNCVkeHUh?=
HMV-II M{jQOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTNzLkO1PVIh|ryP NIDKNlFUSU6JRWK=
NCI-H2087 MoW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofGTWM2OD1|MT62N|UzKM7:TR?= NYizWIhwW0GQR1XS
CAL-54 M3HPO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTNzLkeyOFEh|ryP NHfSZpRUSU6JRWK=
HCC70 MmLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7UcpNWUUN3ME2zNk4yOzh5IN88US=> NVLXPFVyW0GQR1XS
ES1 NXHWe|B7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTN{LkOwOlIh|ryP M4ftbHNCVkeHUh?=
NCI-H1355 NWm3WmhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTN|LkKwOEDPxE1? MluwV2FPT0WU
CFPAC-1 NYjSZlh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvqbmlKSzVyPUOzMlI{OzJizszN M{PrPHNCVkeHUh?=
MKN28 NVfPd4ZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTN|LkO4NFkh|ryP MYDTRW5ITVJ?
HDLM-2 MonuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV72ZlA5UUN3ME2zN{43QTNzIN88US=> MmrFV2FPT0WU
PANC-10-05 MmfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTN2LkGwNVQh|ryP Ml\QV2FPT0WU
SAS NGPuclVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXqyWYhKUUN3ME2zOE41PTZ3IN88US=> MV7TRW5ITVJ?
HCC1395 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fvWGlEPTB;M{SuO|E5PiEQvF2= MVnTRW5ITVJ?
8305C MoDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Prc2lEPTB;M{WuPFQyPSEQvF2= M{j3dnNCVkeHUh?=
KM12 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\6d2lKSzVyPUO2Mlc2PDdizszN M1LUbHNCVkeHUh?=
SW1116 NGHUfIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nKc2lEPTB;M{euOVk6OiEQvF2= NXnvVJI3W0GQR1XS
SK-MEL-1 NUf4ZnV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jQV2lEPTB;M{iuN|M5QSEQvF2= M4DsTXNCVkeHUh?=
HCC2218 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXjRmlKSzVyPUO4MlY2OTlizszN MlTDV2FPT0WU
T84 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXGXHFKSzVyPUO4Mlc1ODlizszN NYr4S5FiW0GQR1XS
ETK-1 NEXLU49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHONHFKSzVyPUO5MlAzOiEQvF2= NHv6V25USU6JRWK=
COLO-800 NFLSXYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1GwSGlEPTB;M{muN|g3QCEQvF2= NI\mPIRUSU6JRWK=
CAL-12T NHHTWoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYiwUnZYUUN3ME2zPU42OjhzIN88US=> MmPkV2FPT0WU
ACN Mnn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjH[JhKSzVyPUSwMlQ6OTFizszN NHu2bWRUSU6JRWK=
SJSA-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVToeGI5UUN3ME20NU4yPTl4IN88US=> NFPROndUSU6JRWK=
PSN1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTDTWM2OD12MT6xO|Q6KM7:TR?= NEHpZ|hUSU6JRWK=
D-566MG MliwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX1T5FKSzVyPUSxMlIxQDZizszN MnvuV2FPT0WU
EGI-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTR{LkSyPEDPxE1? M4CzfHNCVkeHUh?=
A204 M3;kXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjZd4NKSzVyPUSyMlY{QDhizszN MWHTRW5ITVJ?
Saos-2 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2T1eGlEPTB;NEKuPFM3QSEQvF2= Ml;KV2FPT0WU
SNU-C2B NIPaS4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTR|Lk[4O|gh|ryP MmC2V2FPT0WU
HLE M3fsV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zRO2lEPTB;NESuNFg2PiEQvF2= MYPTRW5ITVJ?
SW1463 M3THNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXGWVRKSzVyPUS0Mlk6PzFizszN MoXyV2FPT0WU
DSH1 M{HvZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPLdHZJUUN3ME20OU4xODN|IN88US=> NV;ObFZXW0GQR1XS
MCF7 NEnlZ3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1uzb2lEPTB;NEWuOVA2OSEQvF2= M1X5dnNCVkeHUh?=
K5 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXGz[oJ6UUN3ME20OU46PDB3IN88US=> NXrT[lZpW0GQR1XS
NCI-H358 MkTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DTZWlEPTB;NEeuNlE2KM7:TR?= NFvrSldUSU6JRWK=
NCI-H2030 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTR5LkKzO|Qh|ryP MV7TRW5ITVJ?
SW948 MkjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fjcGlEPTB;NEeuOFY1KM7:TR?= MXHTRW5ITVJ?
BALL-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTR5Lk[xOlgh|ryP NFrQc3FUSU6JRWK=
TE-9 Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVqzWFF7UUN3ME20O{46PThzIN88US=> NUn4[VNHW0GQR1XS
SK-N-FI M1HFd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTR6LkCzOVgh|ryP NHftcYpUSU6JRWK=
KALS-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\UTWM2OD12OD6xNlg6KM7:TR?= M3TNWHNCVkeHUh?=
HO-1-N-1 MmPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;OTWM2OD12OD63OFQ2KM7:TR?= MX3TRW5ITVJ?
NCI-H2452 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTR7LkGxOVIh|ryP M4m3UXNCVkeHUh?=
OC-314 NV3EeG04T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnufHV7UUN3ME20PU43QDN2IN88US=> MoDHV2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
STAT3 / pSTAT3 / STAT6 / pSTAT6 / Mcl-1 / Cleaved Mcl-1 / Bcl-xl / Bim / puma / Bik / Bax / PARP / c-Myc; 

PubMed: 26811457     


(A) Western blot analysis of expressions of STAT3/p-STAT3 and STAT6/p-STAT6 as well as antiapoptotic members (Bcl-2, Bcl-xL, and Mcl-1) after 48 h of treatments in HDLM-2 cells. (B) Western blot analysis of expressions of proapoptotic proteins (Bim, Puma, Bik, Bax, and p-Bad) as well as caspase cascade molecules (PARP and c-Myc) after 48 h of treatments. β-Actin was used as an input control.

caspase3 / cleaved caspase 3; 

PubMed: 24481442     


(b) (i) N/TERT, (ii) SINCE and (iii) SINEG2 cells were either untreated (0 μM/DMSO) or treated with increasing doses of Navitoclax (ABT-263; 0.025–30 μM) and were incubated for 24 h. Next, cells were collected and whole-cell lysates were prepared and immunoblotted against anti-full-length Caspase 3 (∼35 kDa) antibody, whereas β-actin (∼42 kDa) was used as a protein-loading control. Apoptosis was assessed through detecting the cleaved bands of Caspase-3 (∼19, 17 kDa). 

26811457 24481442
Growth inhibition assay
Cell viability; 

PubMed: 25685063     


(C) Hcc827, (D) H292, and (E) H1993 cells were treated with increasing concentrations of albendazole or mebendazole in the presence of navitoclax (0, 1, 2, and 4 μM). Viability was determined after 1 day.

25685063
体内研究 用ABT-263处理H345移植瘤模型,按动物体重,每千克每天处理10mg ABT-263,结果肿瘤生长抑制率达80% ,肿瘤体积减小了50%以上,显示出ABT-263极强的抗癌效果。ABT-263作用于非小细胞肺癌和急性淋巴细胞白血病的移植瘤模型时,每天单独口服,结果显示肿瘤完全衰退。ABT-263单独作用于B-细胞淋巴瘤和多发性骨髓瘤的移植瘤模型时效果不明显,但是可以显著增强临床其他相关用药的药性。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

激酶实验:

用竞争性荧光偏振检测测定ABT-263 作用于Bcl-2 家族不同亚型的Ki值或者IC50值。使用如下的肽探针对或者蛋白对:f-bad (1 nM) 和Bcl-xL (6 nM), f-Bax (1 nM) 和Bcl-2 (10 nM), f-Bax (1 nM) 和Bcl-w (40 nM), f-Noxa (2 nM)和Mcl-1 (40 nM), 及f-Bax (1 nM) 和Bcl-2-A1 (15 nM)。用时间分辨荧光共振能转移法测定ABT-263和Bcl-xL作用的结合紧密度。1 nM 用His标记的Bcl-xL 与200 nM f-Bak,及 1 nM Tb标记的His抗体混合, 然后在室温下处理30分钟。
细胞实验:

[1]

- 合并
  • Cell lines: SCLC 细胞系
  • Concentrations: 0-1 μM
  • Incubation Time: 48小时
  • Method:

    人类肿瘤细胞系在37oC 含5% CO2环境下获得,SCLC 细胞系培养在RPMI 1640培养基中,培养基包含10% 胎牛血清, 1% 丙酮酸钠, 25 mM HEPES, 4.5 g/L葡萄糖, 1% 青霉素/链霉素。用含有10% FBS和1% 青霉素/链霉素的RPMI 1640培养基培养白血病和淋巴癌细胞系。细胞在96孔板上处理48小时,最终体积达到100ul。在体外测试ABT-263的细胞毒性。


    (Only for Reference)
动物实验:

[1]

- 合并
  • Animal Models: C.B.-17严重联合免疫缺陷-米黄鼠
  • Dosages: 100 mg/kg/d
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (102.6 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+corn oil
7mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 974.61
化学式

C47H55ClF3N5O6S3

CAS号 923564-51-6
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04480086 Not yet recruiting Drug: Mivebresib|Drug: Navitoclax|Drug: Ruxolitinib Myelofibrosis (MF) AbbVie July 31 2020 Phase 1
NCT04454658 Not yet recruiting Drug: ABBV-744|Drug: Navitoclax|Drug: Ruxolitinib Myelofibrosis (MF) AbbVie July 14 2020 Phase 1
NCT04041050 Recruiting Drug: Navitoclax|Drug: Ruxolitinib Myeloproliferative Neoplasm AbbVie November 8 2019 Phase 1
NCT03181126 Active not recruiting Drug: Navitoclax|Drug: Chemotherapy|Drug: Venetoclax Acute Lymphoblastic Leukemia (ALL)|Lymphoblastic Lymphoma AbbVie November 27 2017 Phase 1
NCT02520778 Active not recruiting Drug: Navitoclax|Drug: Osimertinib Advanced Lung Non-Squamous Non-Small Cell Carcinoma|Metastatic Lung Non-Squamous Non-Small Cell Carcinoma|Stage III Lung Non-Small Cell Cancer AJCC v7|Stage IIIA Lung Non-Small Cell Cancer AJCC v7|Stage IIIB Lung Non-Small Cell Cancer AJCC v7|Stage IV Lung Non-Small Cell Cancer AJCC v7 National Cancer Institute (NCI) March 31 2016 Phase 1
NCT02591095 Completed Drug: ABT-263 Platinum-resistant or Refractory Ovarian Cancer Centre Francois Baclesse|ARCAGY/ GINECO GROUP|French Cancer Research Hospital Program January 2016 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    I would like to deliver S1001 via i.p. injection, can you suggest a vehicle solution?

  • 回答:

    S1001 ABT-263 (Navitoclax) can be dissolved in 5% DMSO+corn oil at 7mg/ml as a clear solution.

  • 问题 2:

    Could you tell me if the catalog number S1001 can go through the hemato-encephalic barrier?

  • 回答:

    According to the paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223694/, ABT-263 can not cross brain-blood barrier.

Bcl-2 Signaling Pathway Map

Bcl-2 Inhibitors with Unique Features

相关Bcl-2产品

Tags: 购买Navitoclax (ABT-263) | Navitoclax (ABT-263)供应商 | 采购Navitoclax (ABT-263) | Navitoclax (ABT-263)价格 | Navitoclax (ABT-263)生产 | 订购Navitoclax (ABT-263) | Navitoclax (ABT-263)代理商
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID