Navitoclax (ABT-263)

目录号:S1001

仅限科研使用

Navitoclax (ABT-263)是一种有效的Bcl-xLBcl-2Bcl-w抑制剂,无细胞试验中Ki分别为≤0.5 nM,≤1 nM和≤1 nM,但与Mcl-1和A1结合微弱。Phase 2。

Navitoclax (ABT-263) Chemical Structure

CAS: 923564-51-6

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 3285.53 现货
RMB 975.71 现货
RMB 3016.58 现货
RMB 7950.36 现货
大包装 有超大折扣

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客户使用Selleck生产的Navitoclax (ABT-263)发表文献289篇:

产品安全说明书

Bcl-2抑制剂选择性比较

相关Bcl-2产品

生物活性

产品描述 Navitoclax (ABT-263)是一种有效的Bcl-xLBcl-2Bcl-w抑制剂,无细胞试验中Ki分别为≤0.5 nM,≤1 nM和≤1 nM,但与Mcl-1和A1结合微弱。Phase 2。
靶点
Bcl-xL [1]
(Cell-free assay)
Bcl-2 [1]
(Cell-free assay)
Bcl-w [1]
(Cell-free assay)
<=0.5 nM(Ki) <=1 nM(Ki) <=1 nM(Ki)
体外研究

ABT-263有效抑制Bcl-2蛋白家族,用荧光偏振分析法测试ABT-263作用于Bcl-xL, Bcl-2和 Bcl-w时,Ki分别为0.5, 1和1 nM。[1]ABT-263结构上与ABT-737相关。ABT-263阻断Bcl-2 和Bcl-XL与凋亡前体蛋白相互作用。Bcl-2家族成员Bcl-2,Bcl-XL, 和Mcl-1的过量表达通常都与肿瘤的修复及抗药性有关。ABT-263作用于过量表达的Bcl-2 和Bcl-XL时显示出保护作用,EC50分别为60 和20 nM。ABT-263作用于不同的细胞显示出不同的细胞活性,作用于H146细胞系时EC50为110nM,而作用于H82细胞系时EC50为22 µM。ABT-737可以有效作用于四种EC50值 <400 nM的细胞系,即H146, H889, H1963, 和H1417。而两种抗ABT-737的细胞系,即H1048和H82,同样也显示出抗ABT-263的特性。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
FL5.12 NWDyfYN1S3m2b4TvfIlkcXS7IHHzd4F6 NGTWbmUzPCCq M3;le2VEPTBiPTCwMlAxPDJizszN NYLndIgxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4OFE5QDJpPkG4PFQyQDh{PD;hQi=>
FL5.12 M1LqemN6fG:2b4jpZ4l1gSCjc4PhfS=> NFvjZpYzPCCq MVPFR|UxKD1iMD6wNFU6KM7:TR?= M2[yc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OESxPFgzLz5zOEi0NVg5OjxxYU6=
RS4:11 M132dGFxd3C2b4Ppd{Bie3OjeR?= MUK2JIg> NVfaR|JUTUN3MDC9JFAvODF2IN88US=> M3LGVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEixOVY4Lz5{NEi4NVU3PzxxYU6=
FDC-P1 NF\rT4hDS0xvMjDpcohq[mm2aX;uJIF{e2G7 M4fyO|I1KGh? NX;UUIZqUUN3MDC9JFAvODF3IN88US=> NHjXNGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi4NVU3Pyd-MkS4PFE2Pjd:L3G+
NCI-H1963 MlXsR5l1d3SxeHnjbZR6KGG|c3H5 M4HqeVQh\GG7cx?= NGrHNG5KSzVyIE2gNE4xOjZ4IN88US=> NFfLenk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S0PFI6QCd-MkO0OFgzQTh:L3G+
NCI-H187 NWnWT2VUS3m2b4TvfIlkcXS7IHHzd4F6 Mo[3OEBl[Xm| MYfJR|UxKD1iMD6wN|g1KM7:TR?= NGGyWIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S0PFI6QCd-MkO0OFgzQTh:L3G+
NCI-H1417 Mo\IR5l1d3SxeHnjbZR6KGG|c3H5 MXW0JIRigXN? MmjNTWM2OCB;IECuNFU1OiEQvF2= NETuXVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S0PFI6QCd-MkO0OFgzQTh:L3G+
FDC-P1 MW\CR2wugExiaX7obYJqfGmxbjDhd5NigQ>? NVe0Zm9COjRiaB?= NUD6bG1RUUN3MDC9JFAvODZizszN M2PPflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEixOVY4Lz5{NEi4NVU3PzxxYU6=
NCI-H146 M4D0ZmN6fG:2b4jpZ4l1gSCjc4PhfS=> M3nPTlQ5KGh? MmPESWM2OCB;IECuNFg3PyEQvF2= NXnHb|BWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4OFE5QDJpPkG4PFQyQDh{PD;hQi=>
RS4:11 MmrtRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NVHyNpZbTUN3MDC9JFAvOTF{IN88US=> MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{NkK0O{c,Ojh7Mk[yOFc9N2F-
MOLT4 M4DSUWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NELw[4dGSzVyIE2gNE4{ODNizszN NGnUZnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEmyOlI1Pyd-Mki5NlYzPDd:L3G+
EoL-1-cell M2LWc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPtTWM2OD1yLkCwOlY6KM7:TR?= M3[2S|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
MV-4-11 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{eybWlEPTB;MD6wNVU5PiEQvF2= M3X5cFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
NKM-1 Mom3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;mTWM2OD1yLkCxOlk6KM7:TR?= NFrkTGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
ML-2 MkfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlG3TWM2OD1yLkCxPVg{KM7:TR?= Mn2xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
BV-173 NH;pOY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMEKzNVQh|ryP MlnuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
RS4-11 Mn;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMEK1PFch|ryP NHHIcoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
HL-60 NX34[oFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\OTWM2OD1yLkCyPVA5KM7:TR?= NWfr[m5IRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
KY821 M2\vRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\Ic49rUUN3ME2wMlAzQTd3IN88US=> NWnKcmI4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
ECC10 MoX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPzTWM2OD1yLkCzO|kzKM7:TR?= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
NCI-H720 MnmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLWZ5RGUUN3ME2wMlA1ODFzIN88US=> NEK3cJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
QIMR-WIL NYPZUIJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rVVGlEPTB;MD6wOFI5PyEQvF2= NYn0RY54RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
KG-1 NHfWToNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjM[XhKSzVyPUCuNFQ1QDZizszN NUfHUm5YRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
TGW NIXOcWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDhSYJKSzVyPUCuNFQ3OzNizszN MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
ATN-1 NWrzRphbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHRTWM2OD1yLkC0O|M{KM7:TR?= NV\uOXRnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
RH-18 MkjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{C5RWlEPTB;MD6wOlA1QCEQvF2= Mli1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
EW-18 NXfQUm5qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwME[4OFEh|ryP NITDfpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
NB17 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMEexNlQh|ryP M{TtWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
SK-NEP-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fiUmlEPTB;MD6wO|IyOyEQvF2= NInqfGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
P12-ICHIKAWA MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMEe3O|gh|ryP MnrQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
KARPAS-45 M1Xw[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrTNnR5UUN3ME2wMlA4QDF3IN88US=> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
EW-3 NGrQSmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrQcYtDUUN3ME2wMlA5ODV|IN88US=> MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
NB13 M1;rWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTqeo1KUUN3ME2wMlA5OjB|IN88US=> M13VZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
NCI-H209 M{PIeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvye5A4UUN3ME2wMlA5PzB2IN88US=> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
NCI-H1092 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMUCyO|Uh|ryP NUf6U3A1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
NH-12 NXzEVY95T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMUC3OFQh|ryP NVLJc2Y4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
697 NELZfJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37kfWlEPTB;MD6xNFg{QSEQvF2= NW\wPXd2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
KE-37 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXk[XF[UUN3ME2wMlEyOzdizszN MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
MOLT-4 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHp[Y9KSzVyPUCuNVUyPjlizszN MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
CHP-134 M2n5eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMU[zNFYh|ryP NV;RTlh7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
D-283MED NVfDZYFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLqeHA3UUN3ME2wMlE4Pjh4IN88US=> M4OwO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
LU-135 NIPqT|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjwT3VzUUN3ME2wMlE5PTV{IN88US=> MnW4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
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RPMI-2650 MmG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVG3TXNqUUN3ME21MlM3OTZizszN NFf0bnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
IA-LM M4W0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGq3WotKSzVyPUWuN|k5PzFizszN NXT3[FBwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
KP-4 NVLsenM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\Q[4NrUUN3ME21MlQ3OzN2IN88US=> M1rVb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
G-402 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTVwNUG4OlUh|ryP NYfOfJBJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
OS-RC-2 MoT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlL3TWM2OD13LkWyOlA1KM7:TR?= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
NCI-H1155 MlnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTyTWM2OD13LkW0PVU2KM7:TR?= M{PCRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
OE19 NWnXVGNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jHc2lEPTB;NT62PFYzPCEQvF2= Mm\CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
U-2-OS MnrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rafmlEPTB;NT64PVAyOyEQvF2= NHjx[G89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
SCC-15 Ml3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;5fmlEPTB;NT65N|Y3OiEQvF2= NFrVR3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
NCI-H630 M13kPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTVwOUm0NFQh|ryP MkjHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
PFSK-1 M4PSeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULmfFVKUUN3ME22MlA2OjV7IN88US=> M1HnZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
NCI-H1770 MoDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfJTWM2OD14LkKwPFc1KM7:TR?= M4XPNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
SK-MEL-3 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTZwNEK5NVUh|ryP MmC4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
LB1047-RCC NGnoUm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTZwNEe2NlUh|ryP NEj6eII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
NCI-H446 MnvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HDVWlEPTB;Nj62NlkzPSEQvF2= MojiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
SW780 NH\TRZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTZwN{CxPFUh|ryP MlH2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
NEC8 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M376cGlEPTB;Nj63OlY{KM7:TR?= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
NOMO-1 NGi4Sm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfqTWM2OD14Lke4NVEyKM7:TR?= NXK5PYd3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
COLO-668 M2m1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPPelVKSzVyPU[uPFQ{QDdizszN M3rQb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
MC116 Mn;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTZwOUO4PVch|ryP NI\iTlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
HCC1937 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTZwOUmyOVEh|ryP NHfCXmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
NCI-N87 M3zYcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fJ[2lEPTB;Nz6xPVI6OyEQvF2= NHe3VIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
COLO-320-HSR NHW1XG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTdwMkK3N|gh|ryP M2TxXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
HCC1806 M3XrOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTdwMk[wOFQh|ryP M2fNblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
OVCAR-3 M{\2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\xe2lEPTB;Nz6zN|A{QCEQvF2= MmX0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
NUGC-3 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjoNFZFUUN3ME23MlM6Pjl2IN88US=> NIDPSYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
SW1783 NHPpcFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnT0TWM2OD15LkSzNVc2KM7:TR?= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
GCT NXjMSWJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH6y[nNKSzVyPUeuOVY6ODZizszN MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
NCI-H2126 NXPuRo97T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfCNHZKSzVyPUeuO|M3OjVizszN NVftPYp[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
MEL-HO NVvh[JhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTdwN{ewOVQh|ryP M2P0O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
CAPAN-1 NGf5SolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTdwN{ezOVch|ryP M1Tk[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
SW756 MlTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nBdmlEPTB;Nz63PFM{OyEQvF2= NGrtTno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
SKG-IIIa M{HIcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nUPGlEPTB;Nz64NVg6OiEQvF2= NEnFe3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
HCE-T NYDyVXUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlGyTWM2OD15Lki3O|g{KM7:TR?= M1;RXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
Ca-Ski NYXJXox5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTZ[WVKUUN3ME23Mlk6Ozh|IN88US=> NHexNlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
COLO-684 NGjUWZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHP0SpVKSzVyPUiuNFE5OThizszN NUn6c3dGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
KYSE-70 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonPTWM2OD16LkC3O|I6KM7:TR?= NYrLbIhiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
TI-73 NFrjTXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTsWnpKSzVyPUiuNlU5PTFizszN MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
BT-20 NX;Y[INkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPVN|BVUUN3ME24MlI3ODV{IN88US=> NWrlV5NURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
MHH-ES-1 MlXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PPfmlEPTB;OD61NVg{PCEQvF2= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
TE-12 NUTKcY5pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRThwNUm5N|Eh|ryP M3P5OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
YH-13 M4XURWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmr4TWM2OD16Lk[xNFA5KM7:TR?= MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
SF126 NFv6dGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljSTWM2OD16LkizPFY2KM7:TR?= NEniR4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
J82 NVexTIpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTUNXJKSzVyPUiuPVAxOzhizszN NXjWPIlRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
RCC10RGB M3\vN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPRRXJKSzVyPUiuPVk2PjFizszN MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
SK-UT-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\aUYxKSzVyPUmuNFQ6PDVizszN MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
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LB996-RCC NI\XNmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPtTWM2OD17LkG5PFkh|ryP NYC1bXZ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
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BALL-1 NX75XXNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjoTWM2OD12Nz62NVY5KM7:TR?= NYr0XndlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
TE-9 NInic5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTPd2tKSzVyPUS3Mlk2QDFizszN Mn7LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFQ{Pjh2Lze+V2FPT0WUPD;hQi=>
SK-N-FI MoLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFH5SWdKSzVyPUS4MlA{PThizszN NUDofHFJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
KALS-1 NEL0cIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTR6LkGyPFkh|ryP M{Lre|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OzZ6ND:nQnNCVkeHUkyvZV4>
HO-1-N-1 NVP2dI9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzVTWM2OD12OD63OFQ2KM7:TR?= NEXt[ZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDN4OESvK|5USU6JRWK8M4E,
NCI-H2452 NGDRTJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHnOHVxUUN3ME20PU4yOTV{IN88US=> NVz3d4hkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDR|Nki0M{c,W0GQR1XSQE9iRg>?
OC-314 NELHSJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2T1OmlEPTB;NEmuOlg{PCEQvF2= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFM3QDRxJ{7TRW5ITVJ:L3G+
Assay
Methods Test Index PMID
Western blot STAT3 / pSTAT3 / STAT6 / pSTAT6 / Mcl-1 / Cleaved Mcl-1 / Bcl-xl / Bim / puma / Bik / Bax / PARP / c-Myc caspase3 / cleaved caspase 3 26811457 24481442
Growth inhibition assay Cell viability 25685063
体内研究 用ABT-263处理H345移植瘤模型,按动物体重,每千克每天处理10mg ABT-263,结果肿瘤生长抑制率达80% ,肿瘤体积减小了50%以上,显示出ABT-263极强的抗癌效果。ABT-263作用于非小细胞肺癌和急性淋巴细胞白血病的移植瘤模型时,每天单独口服,结果显示肿瘤完全衰退。ABT-263单独作用于B-细胞淋巴瘤和多发性骨髓瘤的移植瘤模型时效果不明显,但是可以显著增强临床其他相关用药的药性。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

  • 激酶实验:

    用竞争性荧光偏振检测测定ABT-263 作用于Bcl-2 家族不同亚型的Ki值或者IC50值。使用如下的肽探针对或者蛋白对:f-bad (1 nM) 和Bcl-xL (6 nM), f-Bax (1 nM) 和Bcl-2 (10 nM), f-Bax (1 nM) 和Bcl-w (40 nM), f-Noxa (2 nM)和Mcl-1 (40 nM), 及f-Bax (1 nM) 和Bcl-2-A1 (15 nM)。用时间分辨荧光共振能转移法测定ABT-263和Bcl-xL作用的结合紧密度。1 nM 用His标记的Bcl-xL 与200 nM f-Bak,及 1 nM Tb标记的His抗体混合, 然后在室温下处理30分钟。

细胞实验:

[1]

  • Cell lines: SCLC 细胞系
  • Concentrations: 0-1 μM
  • Incubation Time: 48小时
  • Method:

    人类肿瘤细胞系在37oC 含5% CO2环境下获得,SCLC 细胞系培养在RPMI 1640培养基中,培养基包含10% 胎牛血清, 1% 丙酮酸钠, 25 mM HEPES, 4.5 g/L葡萄糖, 1% 青霉素/链霉素。用含有10% FBS和1% 青霉素/链霉素的RPMI 1640培养基培养白血病和淋巴癌细胞系。细胞在96孔板上处理48小时,最终体积达到100ul。在体外测试ABT-263的细胞毒性。

动物实验:

[1]

  • Animal Models: C.B.-17严重联合免疫缺陷-米黄鼠
  • Dosages: 100 mg/kg/d
  • Administration: 口服处理

溶解度(25°C)

体外

体内

从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+corn oil

4mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 974.61
化学式

C47H55ClF3N5O6S3

CAS号 923564-51-6
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05358639 Not yet recruiting Drug: Olaparib tablet|Drug: Navitoclax High Grade Serous Carcinoma|Triple Negative Breast Cancer|Ovarian Cancer Sunnybrook Health Sciences Centre|Exactis Innovation|Centre hospitalier de l''Université de Montréal (CHUM)|Princess Margaret Hospital Canada June 15 2022 Phase 1
NCT04480086 Active not recruiting Drug: Mivebresib|Drug: Navitoclax|Drug: Ruxolitinib Myelofibrosis (MF) AbbVie March 17 2021 Phase 1
NCT04454658 Recruiting Drug: ABBV-744|Drug: Navitoclax|Drug: Ruxolitinib Myelofibrosis (MF) AbbVie November 11 2020 Phase 1
NCT04041050 Recruiting Drug: Navitoclax|Drug: Ruxolitinib|Drug: Celecoxib Myeloproliferative Neoplasm AbbVie November 8 2019 Phase 1
NCT03181126 Completed Drug: Navitoclax|Drug: Chemotherapy|Drug: Venetoclax Acute Lymphoblastic Leukemia (ALL)|Lymphoblastic Lymphoma AbbVie November 27 2017 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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操作手册

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常见问题及建议解决方法

问题 1:
I would like to deliver S1001 via i.p. injection, can you suggest a vehicle solution?

回答:
S1001 ABT-263 (Navitoclax) can be dissolved in 5% DMSO+corn oil at 7mg/ml as a clear solution.

问题 2:
Could you tell me if the catalog number S1001 can go through the hemato-encephalic barrier?

回答:
According to the paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223694/, ABT-263 can not cross brain-blood barrier.

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