Navitoclax (ABT-263)

目录号:S1001

Navitoclax (ABT-263) Chemical Structure

Molecular Weight(MW): 974.61

Navitoclax (ABT-263)是一种有效的Bcl-xLBcl-2Bcl-w抑制剂,无细胞试验中Ki分别为≤0.5 nM,≤1 nM和≤1 nM,但与Mcl-1和A1结合微弱。Phase 2。

规格 价格 库存 购买数量  
In DMSO RMB 3285.53 现货
RMB 975.71 现货
RMB 1631.61 现货
RMB 3016.58 现货
RMB 7950.36 现货
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产品安全说明书

Bcl-2抑制剂选择性比较

生物活性

产品描述 Navitoclax (ABT-263)是一种有效的Bcl-xLBcl-2Bcl-w抑制剂,无细胞试验中Ki分别为≤0.5 nM,≤1 nM和≤1 nM,但与Mcl-1和A1结合微弱。Phase 2。
靶点
Bcl-xL [1]
(Cell-free assay)
Bcl-2 [1]
(Cell-free assay)
Bcl-w [1]
(Cell-free assay)
<=0.5 nM(Ki) <=1 nM(Ki) <=1 nM(Ki)
体外研究

ABT-263有效抑制Bcl-2蛋白家族,用荧光偏振分析法测试ABT-263作用于Bcl-xL, Bcl-2和 Bcl-w时,Ki分别为0.5, 1和1 nM。[1]ABT-263结构上与ABT-737相关。ABT-263阻断Bcl-2 和Bcl-XL与凋亡前体蛋白相互作用。Bcl-2家族成员Bcl-2,Bcl-XL, 和Mcl-1的过量表达通常都与肿瘤的修复及抗药性有关。ABT-263作用于过量表达的Bcl-2 和Bcl-XL时显示出保护作用,EC50分别为60 和20 nM。ABT-263作用于不同的细胞显示出不同的细胞活性,作用于H146细胞系时EC50为110nM,而作用于H82细胞系时EC50为22 µM。ABT-737可以有效作用于四种EC50值 <400 nM的细胞系,即H146, H889, H1963, 和H1417。而两种抗ABT-737的细胞系,即H1048和H82,同样也显示出抗ABT-263的特性。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NHrkfVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPMRllKSzVyPUCuNFA3PjlizszN MmD3V2FPT0WU
MV-4-11 MlrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XzR2lEPTB;MD6wNVU5PiEQvF2= MWDTRW5ITVJ?
NKM-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGi0UW9KSzVyPUCuNFE3QTlizszN NYnXe2lNW0GQR1XS
ML-2 Mkn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorFTWM2OD1yLkCxPVg{KM7:TR?= MWrTRW5ITVJ?
BV-173 Mm\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVuxfZdEUUN3ME2wMlAzOzF2IN88US=> NHfreWhUSU6JRWK=
RS4-11 M2LXb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMEK1PFch|ryP MVHTRW5ITVJ?
HL-60 NUXicWFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\LPXV4UUN3ME2wMlAzQTB6IN88US=> MWTTRW5ITVJ?
KY821 NHP1Z4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknUTWM2OD1yLkCyPVc2KM7:TR?= M3LjWXNCVkeHUh?=
ECC10 Mom2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\LSGlEPTB;MD6wN|c6OiEQvF2= MVjTRW5ITVJ?
NCI-H720 NX7CfnVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjDeGlKSzVyPUCuNFQxOTFizszN NXn5SoI6W0GQR1XS
QIMR-WIL NXnQTlFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XDNGlEPTB;MD6wOFI5PyEQvF2= NHGxOIJUSU6JRWK=
KG-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMES0PFYh|ryP MYTTRW5ITVJ?
TGW NIHabVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXRS3dDUUN3ME2wMlA1PjN|IN88US=> M2rhcnNCVkeHUh?=
ATN-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[wZW1FUUN3ME2wMlA1PzN|IN88US=> NVXpeFZFW0GQR1XS
RH-18 M4myS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUf3NFdqUUN3ME2wMlA3ODR6IN88US=> NXj5OZJ[W0GQR1XS
EW-18 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGD1[VBKSzVyPUCuNFY5PDFizszN M1PDeHNCVkeHUh?=
NB17 M4jk[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3qwdmlEPTB;MD6wO|EzPCEQvF2= MknjV2FPT0WU
SK-NEP-1 Ml7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3f2T2lEPTB;MD6wO|IyOyEQvF2= M4PvXHNCVkeHUh?=
P12-ICHIKAWA NXz3SYhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXjfpVMUUN3ME2wMlA4Pzd6IN88US=> NUDzNYZ1W0GQR1XS
KARPAS-45 NEfYTpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnMS3FKSzVyPUCuNFc5OTVizszN MkHBV2FPT0WU
EW-3 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX2zNWZ4UUN3ME2wMlA5ODV|IN88US=> NGfhUW1USU6JRWK=
NB13 M3TOW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7XN4lKSzVyPUCuNFgzODNizszN MVTTRW5ITVJ?
NCI-H209 M2HhTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMEi3NFQh|ryP NYrDN3hPW0GQR1XS
NCI-H1092 NIfQOpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMUCyO|Uh|ryP NWXMUlhOW0GQR1XS
NH-12 NHzTdGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HORmlEPTB;MD6xNFc1PCEQvF2= M1izO3NCVkeHUh?=
697 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3UPZFKSzVyPUCuNVA5OzlizszN MojWV2FPT0WU
KE-37 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\TVGlEPTB;MD6xNVM4KM7:TR?= M1;XXnNCVkeHUh?=
MOLT-4 Mm\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMUWxOlkh|ryP M3zERnNCVkeHUh?=
CHP-134 NYmxeXZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPV[5FHUUN3ME2wMlE3OzB4IN88US=> MYHTRW5ITVJ?
D-283MED NGLVTYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfzRoc5UUN3ME2wMlE4Pjh4IN88US=> MmTyV2FPT0WU
LU-135 NV6wfFRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXLTWM2OD1yLkG4OVUzKM7:TR?= M3z3O3NCVkeHUh?=
LU-134-A M{XGcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XDU2lEPTB;MD6xPFY4OSEQvF2= NHPTTpBUSU6JRWK=
EM-2 NHvqZ5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMUm5NVgh|ryP MVfTRW5ITVJ?
LU-139 NE\uVnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljKTWM2OD1yLkKwOFk5KM7:TR?= M2\xV3NCVkeHUh?=
ALL-PO NIf1R5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXhPGlKSzVyPUCuNlE6QDhizszN NIXrNmVUSU6JRWK=
NB12 M{\zdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfkTWM2OD1yLkKzNVE2KM7:TR?= NFjSOHVUSU6JRWK=
KP-N-YN NF\zXVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDLTWM2OD1yLkKzOVc{KM7:TR?= M3i5XXNCVkeHUh?=
BEN MlPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfHTWM2OD1yLkKzPVY5KM7:TR?= MkfwV2FPT0WU
HCC1569 NX\PZXl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYL5OlZZUUN3ME2wMlI2OTB4IN88US=> MYHTRW5ITVJ?
HuO9 MnLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMk[3NVUh|ryP NVG5UXl1W0GQR1XS
WM-115 NUP3RZZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDzbHB4UUN3ME2wMlI4PzN6IN88US=> NXf2c4twW0GQR1XS
CCRF-CEM NEK5R5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzoOndKSzVyPUCuN|M2OjlizszN NYnveW1TW0GQR1XS
IST-SL1 MmPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPsTWM2OD1yLkO1N|Q{KM7:TR?= MWHTRW5ITVJ?
BE-13 NGXhc5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXWTWM2OD1yLkO2OFU6KM7:TR?= MXTTRW5ITVJ?
COR-L88 NUnEfY5lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwM{[1OEDPxE1? M{nITXNCVkeHUh?=
DOHH-2 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLyTWM2OD1yLkSxNFI{KM7:TR?= M1HaVHNCVkeHUh?=
A704 NX3FTWlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV[xTGl{UUN3ME2wMlQzPjdizszN NU[3dopVW0GQR1XS
KNS-81-FD NV;UPHpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXpTWM2OD1yLkS0NFE4KM7:TR?= M3ezS3NCVkeHUh?=
RPMI-8226 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwNEW2OVIh|ryP MVrTRW5ITVJ?
TGBC24TKB MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7kWpdKSzVyPUCuOFU4PzhizszN MlTWV2FPT0WU
NCI-H1304 MkDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PvW2lEPTB;MD60OlE2PyEQvF2= MVnTRW5ITVJ?
MOLT-13 NEfNTFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Xod2lEPTB;MD60OlYyOyEQvF2= NFfHOGdUSU6JRWK=
EW-22 M1fmdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3ETWM2OD1yLkS2OlcyKM7:TR?= M3j0PXNCVkeHUh?=
MS-1 NXrBUo1{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzpOnk{UUN3ME2wMlQ3QTN|IN88US=> MVHTRW5ITVJ?
RMG-I M1Lzemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwNEm0OlQh|ryP NW\6VY0yW0GQR1XS
NTERA-S-cl-D1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DzSGlEPTB;MD61NFAyQSEQvF2= NYPTe|RNW0GQR1XS
NCI-H1048 NWj2U2xYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTEXoV[UUN3ME2wMlUxQTV|IN88US=> MVTTRW5ITVJ?
SW1417 M2f2fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;HNIJKSzVyPUCuOVU1OzhizszN NIL5WW5USU6JRWK=
DB MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWC0V4t{UUN3ME2wMlU4ODhizszN NHnDOVRUSU6JRWK=
MEG-01 NGP3cGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwNUizNkDPxE1? MVTTRW5ITVJ?
EW-13 Ml33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PtOWlEPTB;MD61PFM1OSEQvF2= MmXrV2FPT0WU
LAMA-84 NX73Unh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwNUmyNFch|ryP MUXTRW5ITVJ?
J-RT3-T3-5 NVi4[|dET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHvTWM2OD1yLk[wPFA5KM7:TR?= NV7ueXJ7W0GQR1XS
MOLT-16 NHT1N2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvEfIdKSzVyPUCuOlUzPjRizszN NUm3TFRpW0GQR1XS
DU-4475 M4TDc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjRTWM2OD1yLk[1OFI4KM7:TR?= Mn;hV2FPT0WU
HAL-01 MmS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{WzW2lEPTB;MD63NlU1QSEQvF2= M4GxbnNCVkeHUh?=
RD NFfVVWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3npcmlEPTB;MD63OVg6QSEQvF2= M{jlN3NCVkeHUh?=
OAW-28 MlToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwN{izO{DPxE1? NW[wN452W0GQR1XS
HCC38 M13GO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;rTWM2OD1yLkiwNVkh|ryP MnPHV2FPT0WU
NMC-G1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXSTWM2OD1yLkixNVIyKM7:TR?= NXvFb5RCW0GQR1XS
EW-16 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[1TWM2OD1yLkixN|I5KM7:TR?= NHHFRVBUSU6JRWK=
DU-145 M{XhPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTk[GxKSzVyPUCuPFk6OjNizszN MYPTRW5ITVJ?
HPAF-II M3TNRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXyPYJnUUN3ME2wMlkzPjJ6IN88US=> NUK4NFVUW0GQR1XS
A427 MnLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjMbpFKSzVyPUCuPVMxOjJizszN MWDTRW5ITVJ?
PA-1 NWP1Z|I3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3aWHhFUUN3ME2wMlk2PjR{IN88US=> NVvQOlFUW0GQR1XS
OAW-42 NYLnOmx{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwOU[xOFYh|ryP M2LLNHNCVkeHUh?=
L-428 MmnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLiTWM2OD1zLkCxNlUh|ryP M2XDfHNCVkeHUh?=
COLO-824 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIS3NWFKSzVyPUGuNFE4ODhizszN M4XveHNCVkeHUh?=
P30-OHK NWHNNmdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTFwMES2PFgh|ryP MoHqV2FPT0WU
NCI-H2170 Mnn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrjWld6UUN3ME2xMlA3OjNizszN NWn3WZhRW0GQR1XS
HCC2998 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LWXWlEPTB;MT6wO|E{PSEQvF2= NWTJW|hVW0GQR1XS
NB14 M3XJcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjmN|IzUUN3ME2xMlE{PzR6IN88US=> M1fubnNCVkeHUh?=
TGBC1TKB NXLGOpJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTFwMUSxOVIh|ryP MXLTRW5ITVJ?
KP-N-YS NFjXZ45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLWTWM2OD1zLkG2NlM3KM7:TR?= M1XFbXNCVkeHUh?=
CAL-120 Mmq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPaRXBKSzVyPUGuNVY1OjlizszN NXLUWoJJW0GQR1XS
SBC-1 NIDhRnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\RNWlEPTB;MT6xPVA2OyEQvF2= NWPoXol[W0GQR1XS
C32 M163O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXhPWN{UUN3ME2xMlE6ODh6IN88US=> NUHQc3ZxW0GQR1XS
HCC2157 NUmyd3FiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7KTWM2OD1zLkG5OFk1KM7:TR?= NXr6[JB3W0GQR1XS
COLO-792 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nZR2lEPTB;MT6yNFA4OSEQvF2= NWrSV2hlW0GQR1XS
ES7 M1TwS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTFwMke5OVEh|ryP NEfiN|hUSU6JRWK=
HEL MlrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTFwM{GwNlkh|ryP MVHTRW5ITVJ?
ES4 NVviV2Y2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;vVmlEPTB;MT6zOFk6QCEQvF2= MUjTRW5ITVJ?
NCI-SNU-1 NG[4WplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfVSmJZUUN3ME2xMlM3PTV3IN88US=> NXzINVZmW0GQR1XS
MDA-MB-415 NXPvdmZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXu1ZWZKUUN3ME2xMlM5QDVizszN M4D5[3NCVkeHUh?=
NCI-H2342 NYHNW5F[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nt[mlEPTB;MT60NFI3QSEQvF2= NFr5UHNUSU6JRWK=
NB69 Mn;ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTxW3htUUN3ME2xMlQ3OjdzIN88US=> MWXTRW5ITVJ?
D-247MG MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;qV2hKSzVyPUGuOVEyOjJizszN MUnTRW5ITVJ?
SCC-4 M{DmSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTFwNUm4PFch|ryP NWXXfFBGW0GQR1XS
HuH-7 M1PIVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLHNXd1UUN3ME2xMlY4Ojl|IN88US=> MoW1V2FPT0WU
A388 NHPKeZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDndHZKSzVyPUGuOlg4OjRizszN MmPkV2FPT0WU
Calu-3 NUHQVFFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TNV2lEPTB;MT63NFY6PyEQvF2= MXXTRW5ITVJ?
NCI-H1648 M2fzT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fzTWlEPTB;MT63NVQyQCEQvF2= M3nwVnNCVkeHUh?=
NCI-H2052 Mly0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3q4e2lEPTB;MT63NlIxOSEQvF2= M1fsfnNCVkeHUh?=
Ramos-2G6-4C10 Moq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTFwN{O2OVYh|ryP NV7PZpZkW0GQR1XS
DEL Mmi1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVm3XYNlUUN3ME2xMlc1Pjl{IN88US=> NWH3SIhnW0GQR1XS
SNU-423 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDZTWM2OD1zLke4NVU4KM7:TR?= MknDV2FPT0WU
COR-L23 MnrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjFWJhqUUN3ME2xMlc6QDd2IN88US=> MVTTRW5ITVJ?
OMC-1 Mkj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULEUIVNUUN3ME2xMlg3ODF4IN88US=> MVfTRW5ITVJ?
EW-11 NVnXUmx{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1K1fWlEPTB;MT65OVY2PyEQvF2= MWLTRW5ITVJ?
HSC-3 NI\FT3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\NdmlEPTB;MT65OlM3PSEQvF2= MY\TRW5ITVJ?
MLMA M1XxbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fRXmlEPTB;MT65OlY4PyEQvF2= MmToV2FPT0WU
RCM-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTJwMECzPVkh|ryP Mmn0V2FPT0WU
MFE-280 NFjsRYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUm2TppKUUN3ME2yMlAzQDR6IN88US=> NFzH[HNUSU6JRWK=
ES8 NFXCU5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:wTWM2OD1{LkK1OFcyKM7:TR?= MYHTRW5ITVJ?
TE-11 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;tTWM2OD1{LkK5OFc{KM7:TR?= MVjTRW5ITVJ?
HuO-3N1 MnvlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoeyTWM2OD1{LkS4O|gh|ryP NES0W29USU6JRWK=
MHH-NB-11 MmPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTJwNUGxOVgh|ryP MnzBV2FPT0WU
TGBC11TKB MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDYTWM2OD1{LkW3OlgyKM7:TR?= NF[xb5pUSU6JRWK=
HOP-92 Ml;ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmG0TWM2OD1{LkW4O|Q{KM7:TR?= MmPxV2FPT0WU
IGR-1 NFn3[pVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPKTWM2OD1{Lk[yNFM2KM7:TR?= NGr5[W5USU6JRWK=
GOTO NXfkbGlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rObWlEPTB;Mj62OVM4PyEQvF2= Mm\PV2FPT0WU
NCI-H1650 MmXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTJwN{KyNVUh|ryP MUPTRW5ITVJ?
NCI-H1581 NE\MWZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTJwN{m2PFEh|ryP NH;hPVBUSU6JRWK=
NCI-H2405 NUjZNYdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPRXZpOUUN3ME2yMlgzPzh{IN88US=> MUDTRW5ITVJ?
U-118-MG NFLqcFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\Wfmh3UUN3ME2yMlk3PDlzIN88US=> NVfHbFR4W0GQR1XS
DoTc2-4510 M136U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGCwXG1KSzVyPUOuNFE1OTdizszN NULPfmc2W0GQR1XS
NCI-H596 M1fLeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TYe2lEPTB;Mz6wOFk6PyEQvF2= MnzTV2FPT0WU
MPP-89 NHPFVWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTNwMEW2OlYh|ryP M3TvbXNCVkeHUh?=
GCIY MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPlTWM2OD1|LkKwOFkyKM7:TR?= MWrTRW5ITVJ?
SW626 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTNwMkS1OFMh|ryP NWTMOI8{W0GQR1XS
OCI-AML2 NUjZXVVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\VTWM2OD1|LkOxNlczKM7:TR?= MmT6V2FPT0WU
NBsusSR MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTNwM{S5N|gh|ryP M3HIW3NCVkeHUh?=
AN3-CA MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzLUpBKSzVyPUOuOFQzOzhizszN MoXQV2FPT0WU
EFM-19 MoCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknMTWM2OD1|LkS4N|M6KM7:TR?= MnO3V2FPT0WU
RVH-421 M{LZOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTNwNU[4O|ch|ryP MYfTRW5ITVJ?
5637 NGXuUYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXHTWM2OD1|Lk[xNVA{KM7:TR?= NITmfoJUSU6JRWK=
PANC-08-13 Ml3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULOcW53UUN3ME2zMlY{PDd{IN88US=> NE[3[FBUSU6JRWK=
H9 MkPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfiTWM2OD1|Lk[3NVQ1KM7:TR?= M2PqRnNCVkeHUh?=
KARPAS-299 NHHMTIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULhT2VVUUN3ME2zMlY4OzZzIN88US=> MlTkV2FPT0WU
TE-5 M1;G[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnxTFRkUUN3ME2zMlcxPzB7IN88US=> MYnTRW5ITVJ?
NOS-1 Ml30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHxb4dKSzVyPUOuO|k5OzRizszN NXTWWIlFW0GQR1XS
HH NGr0[oZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHS5VG9KSzVyPUOuPFM5PjhizszN NEPCe2hUSU6JRWK=
769-P MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPCTWM2OD1|Lki5OVEh|ryP MoiyV2FPT0WU
CHP-212 M{H5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M365fmlEPTB;Mz65NlU1QSEQvF2= MWnTRW5ITVJ?
NCI-H82 Ml;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoewTWM2OD1|Lkm1PVM3KM7:TR?= MVLTRW5ITVJ?
Mo-T Ml62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnwW5hKSzVyPUSuNFQ{OTJizszN MWPTRW5ITVJ?
BB65-RCC MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TTU2lEPTB;ND6wOFM6QSEQvF2= NFnNVnNUSU6JRWK=
SW1990 Mn3XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnSd3VKSzVyPUSuNFU6ODhizszN MXrTRW5ITVJ?
LK-2 NUnMdG9nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTRwMUGyPVMh|ryP NY\GT21IW0GQR1XS
ES5 NWe0[HdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmH1TWM2OD12LkGzPVg2KM7:TR?= NWDoO5FJW0GQR1XS
JVM-3 M{fwW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17BSGlEPTB;ND6xPFIzOiEQvF2= MoXHV2FPT0WU
RPMI-7951 M1TPdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXrTWM2OD12LkKyOFE{KM7:TR?= MlPlV2FPT0WU
Calu-6 NEG5[49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\iXGlEPTB;ND6yO|g5OSEQvF2= MnSzV2FPT0WU
LC-2-ad Mo\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:xU|ByUUN3ME20MlI6PTZ6IN88US=> NEPNRoZUSU6JRWK=
SW954 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTRwMkm2OkDPxE1? M1nHZ3NCVkeHUh?=
H-EMC-SS NYfaTYVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHBTWM2OD12LkOxPFMyKM7:TR?= MWHTRW5ITVJ?
ES3 NYfDV|FoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XOVGlEPTB;ND6zOVQ1OSEQvF2= NVu1NXJyW0GQR1XS
no-11 NW\PPWpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DVcGlEPTB;ND6zOVU2PCEQvF2= MUXTRW5ITVJ?
LAN-6 NIDKdVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zX[GlEPTB;ND60OVE5QSEQvF2= NEfrUnNUSU6JRWK=
FTC-133 NFHPNZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXT6bJg3UUN3ME20MlU{QTVizszN NV;1V5lIW0GQR1XS
8505C NV3ndXVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fJO2lEPTB;ND61OFI{KM7:TR?= MnrVV2FPT0WU
SW620 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLHTnpbUUN3ME20MlU4ODV5IN88US=> MUTTRW5ITVJ?
BCPAP NXzUVYUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrZTWM2OD12Lk[zOFgyKM7:TR?= MXfTRW5ITVJ?
SK-LU-1 NGPIZmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnWW4RKSzVyPUSuOlYxQDlizszN M2DkXHNCVkeHUh?=
NCI-H1623 MnPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLLTWM2OD12LkewNlI5KM7:TR?= NIDk[XpUSU6JRWK=
C2BBe1 NEXSPWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnaNXJKSzVyPUSuO|QxODhizszN M4nNZnNCVkeHUh?=
GP5d MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3v6OGlEPTB;ND63PFM5QCEQvF2= NGX1cHBUSU6JRWK=
NB6 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[2VWdnUUN3ME20Mlg3OjB2IN88US=> NVzNUJRYW0GQR1XS
MDA-MB-157 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTRwOEi3OkDPxE1? M3Ph[HNCVkeHUh?=
UMC-11 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\XNI16UUN3ME20Mlg5QTZ2IN88US=> MVTTRW5ITVJ?
HCC1419 MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTRwOUCwOlMh|ryP NXz4dWozW0GQR1XS
NCI-H2029 NH3GdYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\UTWM2OD12Lkm0NVg2KM7:TR?= Ml;3V2FPT0WU
LXF-289 NWrFOFUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13D[WlEPTB;NT6wN|cyQSEQvF2= M1O2VHNCVkeHUh?=
KINGS-1 NFH4[FRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;MTWM2OD13LkC3O|Q1KM7:TR?= MVTTRW5ITVJ?
HD-MY-Z NIrQ[ZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLnTWM2OD13LkKzPVY6KM7:TR?= NH\HT41USU6JRWK=
ESS-1 NVjmXVdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nPXWlEPTB;NT6yOVU6PyEQvF2= M1uwe3NCVkeHUh?=
GI-1 NGC0[4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vwfGlEPTB;NT6yO|kzPiEQvF2= MlnFV2FPT0WU
RPMI-2650 NH3ZPIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2n0dWlEPTB;NT6zOlE3KM7:TR?= M3\sXnNCVkeHUh?=
IA-LM NY\FbnA5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITjVZdKSzVyPUWuN|k5PzFizszN MXPTRW5ITVJ?
KP-4 M4HS[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fLcGlEPTB;NT60OlM{PCEQvF2= MmfYV2FPT0WU
G-402 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTwZllKSzVyPUWuOVE5PjVizszN MYXTRW5ITVJ?
OS-RC-2 NYXzTo12T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPZTZFUUUN3ME21MlUzPjB2IN88US=> M2rZbnNCVkeHUh?=
NCI-H1155 M4\ZZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4ftW2lEPTB;NT61OFk2PSEQvF2= NYDGb4ZRW0GQR1XS
OE19 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEP0bYZKSzVyPUWuOlg3OjRizszN MmLzV2FPT0WU
U-2-OS Mlj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmC2TWM2OD13Lki5NFE{KM7:TR?= NXvoV|UzW0GQR1XS
SCC-15 M4jN[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTVwOUO2OlIh|ryP NV:5NY9zW0GQR1XS
NCI-H630 NWHkZ2tST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPwepBKSzVyPUWuPVk1ODRizszN MmTNV2FPT0WU
PFSK-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTZwMEWyOVkh|ryP M3XJN3NCVkeHUh?=
NCI-H1770 NIfKZo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTZwMkC4O|Qh|ryP Mmq4V2FPT0WU
SK-MEL-3 NITIUWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDlNYRiUUN3ME22MlQzQTF3IN88US=> NHrQb29USU6JRWK=
LB1047-RCC NFOySpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7XcHlKSzVyPU[uOFc3OjVizszN MXjTRW5ITVJ?
NCI-H446 M17QTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\CTWM2OD14Lk[yPVI2KM7:TR?= MoDRV2FPT0WU
SW780 M{Wy[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXre4FKSzVyPU[uO|AyQDVizszN MlXmV2FPT0WU
NEC8 Ml63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTCTWM2OD14Lke2OlMh|ryP M2PwcXNCVkeHUh?=
NOMO-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLETWM2OD14Lke4NVEyKM7:TR?= NGrTd3ZUSU6JRWK=
COLO-668 NVv6RZpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTuTWM2OD14Lki0N|g4KM7:TR?= M4rPc3NCVkeHUh?=
MC116 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;QNmlEPTB;Nj65N|g6PyEQvF2= MUXTRW5ITVJ?
HCC1937 NHXIWXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvVeGFCUUN3ME22Mlk6OjVzIN88US=> NEXoV21USU6JRWK=
NCI-N87 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTdwMUmyPVMh|ryP Mof3V2FPT0WU
COLO-320-HSR MnzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTdwMkK3N|gh|ryP NFToPVRUSU6JRWK=
HCC1806 NUHIZWJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3tTWM2OD15LkK2NFQ1KM7:TR?= NGLvNFJUSU6JRWK=
OVCAR-3 M1vNXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTdwM{OwN|gh|ryP Mne0V2FPT0WU
NUGC-3 Mnv1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4[3emlEPTB;Nz6zPVY6PCEQvF2= NF7HZpFUSU6JRWK=
SW1783 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXmb4hCUUN3ME23MlQ{OTd3IN88US=> M4jZN3NCVkeHUh?=
GCT NXi5XndQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDBdVd4UUN3ME23MlU3QTB4IN88US=> M2mw[3NCVkeHUh?=
NCI-H2126 NXHBV5N4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTdwN{O2NlUh|ryP NH7ubmhUSU6JRWK=
MEL-HO NGHvXnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkS2TWM2OD15Lke3NFU1KM7:TR?= MlnPV2FPT0WU
CAPAN-1 M1m5Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zRWGlEPTB;Nz63O|M2PyEQvF2= NECzS5dUSU6JRWK=
SW756 NES3NVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTdwN{izN|Mh|ryP M3r6NnNCVkeHUh?=
SKG-IIIa M3rTdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTqWm5VUUN3ME23MlgyQDl{IN88US=> NVLYepcxW0GQR1XS
HCE-T M1TNXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjJTWM2OD15Lki3O|g{KM7:TR?= MXzTRW5ITVJ?
Ca-Ski MnfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoCxTWM2OD15Lkm5N|g{KM7:TR?= NWDUbVVoW0GQR1XS
COLO-684 NUjrV29tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoK1TWM2OD16LkCxPFE5KM7:TR?= MkLXV2FPT0WU
KYSE-70 NYDDeJB[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\qPHJKSzVyPUiuNFc4OjlizszN MonJV2FPT0WU
TI-73 MoDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{ntR2lEPTB;OD6yOVg2OSEQvF2= M1PEcnNCVkeHUh?=
BT-20 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVv4dnBTUUN3ME24MlI3ODV{IN88US=> NYfRSFF{W0GQR1XS
MHH-ES-1 NVXSN4U3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHyxVXdKSzVyPUiuOVE5OzRizszN M2rEO3NCVkeHUh?=
TE-12 NWPVfHFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4X5PGlEPTB;OD61PVk{OSEQvF2= NHLYOXVUSU6JRWK=
YH-13 M37Cbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRThwNkGwNFgh|ryP M2\1cnNCVkeHUh?=
SF126 Mnv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDoV49KSzVyPUiuPFM5PjVizszN NILDd5lUSU6JRWK=
J82 M{PBNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPP[WFKSzVyPUiuPVAxOzhizszN NFjocpZUSU6JRWK=
RCC10RGB M1jxWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPORodKSzVyPUiuPVk2PjFizszN NUjjO|BZW0GQR1XS
SK-UT-1 M1vkbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rrcGlEPTB;OT6wOFk1PSEQvF2= NXr0Sot7W0GQR1XS
LB2241-RCC MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDvTWM2OD17LkG5NVM4KM7:TR?= MojzV2FPT0WU
LB996-RCC NXf6TWxET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTlwMUm4PUDPxE1? NGfKO3hUSU6JRWK=
EPLC-272H M1K0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DMTmlEPTB;OT6zO|Y2PyEQvF2= NFy0W|RUSU6JRWK=
CTV-1 MnLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrGXGp2UUN3ME25MlU3PTN{IN88US=> Ml\GV2FPT0WU
HSC-2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DmOmlEPTB;OT61O|U2KM7:TR?= NH7HcnRUSU6JRWK=
SK-MEL-28 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLKTWM2OD17Lk[xPFk{KM7:TR?= MXrTRW5ITVJ?
MMAC-SF MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUO2S417UUN3ME25MlY5PzVizszN MnHrV2FPT0WU
CP50-MEL-B MnW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzxTWM2OD17Lke1O|gzKM7:TR?= M4\TXXNCVkeHUh?=
HT-1080 MmLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1L2XmlEPTB;OT63O|c{QSEQvF2= MojOV2FPT0WU
HEC-1 NVrQTYRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzqR4xoUUN3ME2xNE4{OzV{IN88US=> NUTyZo05W0GQR1XS
AGS M1P6[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTFyLkO3OEDPxE1? MoTuV2FPT0WU
GAMG MnH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVP3c4lIUUN3ME2xNE42OTZ{IN88US=> NXzvXG5HW0GQR1XS
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A204 NIPxfZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7FTWM2OD12Mj62N|g5KM7:TR?= M3vwVnNCVkeHUh?=
Saos-2 Mn\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37PdGlEPTB;NEKuPFM3QSEQvF2= NXLMUI9rW0GQR1XS
SNU-C2B MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rkbmlEPTB;NEOuOlg4QCEQvF2= MkiyV2FPT0WU
HLE NV;ZR|dPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnkTWM2OD12ND6wPFU3KM7:TR?= MXTTRW5ITVJ?
SW1463 MonsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfHdZhKSzVyPUS0Mlk6PzFizszN NEXEd3lUSU6JRWK=
DSH1 NIXUUZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTLTWM2OD12NT6wNFM{KM7:TR?= NEDSZYVUSU6JRWK=
MCF7 M2PXbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHROHlKSzVyPUS1MlUxPTFizszN MmDzV2FPT0WU
K5 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnaWoNMUUN3ME20OU46PDB3IN88US=> Mke0V2FPT0WU
NCI-H358 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWD2NGlsUUN3ME20O{4zOTVizszN NIf0eGFUSU6JRWK=
NCI-H2030 Mn;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYWzbZQ4UUN3ME20O{4zOzd2IN88US=> M1qw[HNCVkeHUh?=
SW948 NIr0UmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTR5LkS2OEDPxE1? NHLOfZpUSU6JRWK=
BALL-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHu1TWtKSzVyPUS3MlYyPjhizszN NHf2O4RUSU6JRWK=
TE-9 MoX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\sTWM2OD12Nz65OVgyKM7:TR?= NYr2PHlrW0GQR1XS
SK-N-FI NYT2cHU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfiNJZKSzVyPUS4MlA{PThizszN MkXhV2FPT0WU
KALS-1 NULPTo54T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfWU21OUUN3ME20PE4yOjh7IN88US=> M4DGWnNCVkeHUh?=
HO-1-N-1 MoqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1v5VGlEPTB;NEiuO|Q1PSEQvF2= NUC2R5puW0GQR1XS
NCI-H2452 MlrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXkTWM2OD12OT6xNVUzKM7:TR?= MWPTRW5ITVJ?
OC-314 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTR7Lk[4N|Qh|ryP M3HGcHNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
STAT3 / pSTAT3 / STAT6 / pSTAT6 / Mcl-1 / Cleaved Mcl-1 / Bcl-xl / Bim / puma / Bik / Bax / PARP / c-Myc; 

PubMed: 26811457     


(A) Western blot analysis of expressions of STAT3/p-STAT3 and STAT6/p-STAT6 as well as antiapoptotic members (Bcl-2, Bcl-xL, and Mcl-1) after 48 h of treatments in HDLM-2 cells. (B) Western blot analysis of expressions of proapoptotic proteins (Bim, Puma, Bik, Bax, and p-Bad) as well as caspase cascade molecules (PARP and c-Myc) after 48 h of treatments. β-Actin was used as an input control.

caspase3 / cleaved caspase 3; 

PubMed: 24481442     


(b) (i) N/TERT, (ii) SINCE and (iii) SINEG2 cells were either untreated (0 μM/DMSO) or treated with increasing doses of Navitoclax (ABT-263; 0.025–30 μM) and were incubated for 24 h. Next, cells were collected and whole-cell lysates were prepared and immunoblotted against anti-full-length Caspase 3 (∼35 kDa) antibody, whereas β-actin (∼42 kDa) was used as a protein-loading control. Apoptosis was assessed through detecting the cleaved bands of Caspase-3 (∼19, 17 kDa). 

26811457 24481442
Growth inhibition assay
Cell viability; 

PubMed: 25685063     


(C) Hcc827, (D) H292, and (E) H1993 cells were treated with increasing concentrations of albendazole or mebendazole in the presence of navitoclax (0, 1, 2, and 4 μM). Viability was determined after 1 day.

25685063
体内研究 用ABT-263处理H345移植瘤模型,按动物体重,每千克每天处理10mg ABT-263,结果肿瘤生长抑制率达80% ,肿瘤体积减小了50%以上,显示出ABT-263极强的抗癌效果。ABT-263作用于非小细胞肺癌和急性淋巴细胞白血病的移植瘤模型时,每天单独口服,结果显示肿瘤完全衰退。ABT-263单独作用于B-细胞淋巴瘤和多发性骨髓瘤的移植瘤模型时效果不明显,但是可以显著增强临床其他相关用药的药性。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

激酶实验:

用竞争性荧光偏振检测测定ABT-263 作用于Bcl-2 家族不同亚型的Ki值或者IC50值。使用如下的肽探针对或者蛋白对:f-bad (1 nM) 和Bcl-xL (6 nM), f-Bax (1 nM) 和Bcl-2 (10 nM), f-Bax (1 nM) 和Bcl-w (40 nM), f-Noxa (2 nM)和Mcl-1 (40 nM), 及f-Bax (1 nM) 和Bcl-2-A1 (15 nM)。用时间分辨荧光共振能转移法测定ABT-263和Bcl-xL作用的结合紧密度。1 nM 用His标记的Bcl-xL 与200 nM f-Bak,及 1 nM Tb标记的His抗体混合, 然后在室温下处理30分钟。
细胞实验:

[1]

- 合并
  • Cell lines: SCLC 细胞系
  • Concentrations: 0-1 μM
  • Incubation Time: 48小时
  • Method:

    人类肿瘤细胞系在37oC 含5% CO2环境下获得,SCLC 细胞系培养在RPMI 1640培养基中,培养基包含10% 胎牛血清, 1% 丙酮酸钠, 25 mM HEPES, 4.5 g/L葡萄糖, 1% 青霉素/链霉素。用含有10% FBS和1% 青霉素/链霉素的RPMI 1640培养基培养白血病和淋巴癌细胞系。细胞在96孔板上处理48小时,最终体积达到100ul。在体外测试ABT-263的细胞毒性。


    (Only for Reference)
动物实验:

[1]

- 合并
  • Animal Models: C.B.-17严重联合免疫缺陷-米黄鼠
  • Formulation: ABT-263在10% 乙醇, 30% 聚乙二醇400, 及60% Phosal 50 PG中制成
  • Dosages: 100 mg/kg/d
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (102.6 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+corn oil
7mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 974.61
化学式

C47H55ClF3N5O6S3

CAS号 923564-51-6
储存条件 粉状
溶于溶剂
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03181126 Recruiting Drug: Navitoclax|Drug: Chemotherapy|Drug: Venetoclax Acute Lymphoblastic Leukemia (ALL)|Lymphoblastic Lymphoma AbbVie November 27 2017 Phase 1
NCT02520778 Recruiting Drug: Navitoclax|Drug: Osimertinib Advanced Lung Non-Squamous Non-Small Cell Carcinoma|EGFR Exon 19 Deletion Mutation|EGFR NP_005219.2:p.L858R|EGFR NP_005219.2:p.T790M|Metastatic Lung Non-Squamous Non-Small Cell Carcinoma|Stage III Lung Non-Small Cell Cancer AJCC v7|Stage IIIA Lung Non-Small Cell Cancer AJCC v7|Stage IIIB Lung Non-Small Cell Cancer AJCC v7|Stage IV Lung Non-Small Cell Cancer AJCC v7 National Cancer Institute (NCI) March 31 2016 Phase 1
NCT02591095 Completed Drug: ABT-263 Platinum-resistant or Refractory Ovarian Cancer Centre Francois Baclesse|ARCAGY/ GINECO GROUP|French Cancer Research Hospital Program January 2016 Phase 2
NCT02079740 Recruiting Biological: Navitoclax|Drug: Trametinib Advanced Malignant Solid Neoplasm|Malignant Female Reproductive System Neoplasm|Metastatic Malignant Solid Neoplasm|Recurrent Lung Carcinoma|Recurrent Malignant Solid Neoplasm|Recurrent Pancreatic Carcinoma|Stage III Lung Cancer AJCC v7|Stage III Pancreatic Cancer AJCC v6 and v7|Stage IV Lung Cancer AJCC v7|Stage IV Pancreatic Cancer AJCC v6 and v7|Unresectable Malignant Solid Neoplasm National Cancer Institute (NCI) March 7 2014 Phase 1|Phase 2
NCT00887757 Completed Drug: ABT-263|Drug: gemcitabine Solid Tumors AbbVie|Genentech Inc. September 2009 Phase 1
NCT00888108 Completed Drug: ABT-263|Drug: Docetaxel Solid Tumor Abbott|Genentech Inc. July 2009 Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    I would like to deliver S1001 via i.p. injection, can you suggest a vehicle solution?

  • 回答:

    S1001 ABT-263 (Navitoclax) can be dissolved in 5% DMSO+corn oil at 7mg/ml as a clear solution.

  • 问题 2:

    Could you tell me if the catalog number S1001 can go through the hemato-encephalic barrier?

  • 回答:

    According to the paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223694/, ABT-263 can not cross brain-blood barrier.

Bcl-2 Signaling Pathway Map

Bcl-2 Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID