Navitoclax (ABT-263)

目录号:S1001

Navitoclax (ABT-263) Chemical Structure

Molecular Weight(MW): 974.61

Navitoclax (ABT-263)是一种有效的Bcl-xLBcl-2Bcl-w抑制剂,无细胞试验中Ki分别为≤0.5 nM,≤1 nM和≤1 nM,但与Mcl-1和A1结合微弱。Phase 2。

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产品安全说明书

Bcl-2抑制剂选择性比较

生物活性

产品描述 Navitoclax (ABT-263)是一种有效的Bcl-xLBcl-2Bcl-w抑制剂,无细胞试验中Ki分别为≤0.5 nM,≤1 nM和≤1 nM,但与Mcl-1和A1结合微弱。Phase 2。
靶点
Bcl-xL [1]
(Cell-free assay)
Bcl-2 [1]
(Cell-free assay)
Bcl-w [1]
(Cell-free assay)
<=0.5 nM(Ki) <=1 nM(Ki) <=1 nM(Ki)
体外研究

ABT-263有效抑制Bcl-2蛋白家族,用荧光偏振分析法测试ABT-263作用于Bcl-xL, Bcl-2和 Bcl-w时,Ki分别为0.5, 1和1 nM。[1]ABT-263结构上与ABT-737相关。ABT-263阻断Bcl-2 和Bcl-XL与凋亡前体蛋白相互作用。Bcl-2家族成员Bcl-2,Bcl-XL, 和Mcl-1的过量表达通常都与肿瘤的修复及抗药性有关。ABT-263作用于过量表达的Bcl-2 和Bcl-XL时显示出保护作用,EC50分别为60 和20 nM。ABT-263作用于不同的细胞显示出不同的细胞活性,作用于H146细胞系时EC50为110nM,而作用于H82细胞系时EC50为22 µM。ABT-737可以有效作用于四种EC50值 <400 nM的细胞系,即H146, H889, H1963, 和H1417。而两种抗ABT-737的细胞系,即H1048和H82,同样也显示出抗ABT-263的特性。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell M3jzS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz3OYFKSzVyPUCuNFA3PjlizszN NHLsbZNUSU6JRWK=
MV-4-11 NHPwSWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PudmlEPTB;MD6wNVU5PiEQvF2= NVn2OXUyW0GQR1XS
NKM-1 Ml\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMEG2PVkh|ryP MWnTRW5ITVJ?
ML-2 MnmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLoTWM2OD1yLkCxPVg{KM7:TR?= M2PCcHNCVkeHUh?=
BV-173 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPrN3dKSzVyPUCuNFI{OTRizszN NYXCU3R[W0GQR1XS
RS4-11 NILXfoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jzVWlEPTB;MD6wNlU5PyEQvF2= M1TNcnNCVkeHUh?=
HL-60 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnDZmJPUUN3ME2wMlAzQTB6IN88US=> NEC5W3pUSU6JRWK=
KY821 Mn7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMEK5O|Uh|ryP NUTrbm5WW0GQR1XS
ECC10 NEOwSIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\XTWM2OD1yLkCzO|kzKM7:TR?= M3HvN3NCVkeHUh?=
NCI-H720 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zpPWlEPTB;MD6wOFAyOSEQvF2= MlnuV2FPT0WU
QIMR-WIL MnrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXizVndCUUN3ME2wMlA1Ojh5IN88US=> M3\LTXNCVkeHUh?=
KG-1 M2H5eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nwT2lEPTB;MD6wOFQ5PiEQvF2= MVrTRW5ITVJ?
TGW M{Xw[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\qcVhYUUN3ME2wMlA1PjN|IN88US=> Mn\zV2FPT0WU
ATN-1 NVK0T212T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFW5O21KSzVyPUCuNFQ4OzNizszN M3;EXnNCVkeHUh?=
RH-18 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnRSIlOUUN3ME2wMlA3ODR6IN88US=> M1fnc3NCVkeHUh?=
EW-18 MmH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2D6SWlEPTB;MD6wOlg1OSEQvF2= M4n2d3NCVkeHUh?=
NB17 NVjh[FlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMEexNlQh|ryP MknXV2FPT0WU
SK-NEP-1 Mn;ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3wfZhqUUN3ME2wMlA4OjF|IN88US=> MnrZV2FPT0WU
P12-ICHIKAWA MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPkUWxKSzVyPUCuNFc4PzhizszN MkC4V2FPT0WU
KARPAS-45 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMEe4NVUh|ryP M{XtXHNCVkeHUh?=
EW-3 NV;aTIpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\aPGlEPTB;MD6wPFA2OyEQvF2= MVXTRW5ITVJ?
NB13 NFLJb2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorPTWM2OD1yLkC4NlA{KM7:TR?= M4OzWnNCVkeHUh?=
NCI-H209 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHITWM2OD1yLkC4O|A1KM7:TR?= NFnYZmpUSU6JRWK=
NCI-H1092 NWPQ[pBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPhSGNKSzVyPUCuNVAzPzVizszN NVy0fVU5W0GQR1XS
NH-12 M1rReGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrWTVk6UUN3ME2wMlExPzR2IN88US=> M4niRnNCVkeHUh?=
697 NWfGWWV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMUC4N|kh|ryP MYjTRW5ITVJ?
KE-37 M2KxdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnKzTWM2OD1yLkGxN|ch|ryP MUTTRW5ITVJ?
MOLT-4 NVfofI9XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mon6TWM2OD1yLkG1NVY6KM7:TR?= MX;TRW5ITVJ?
CHP-134 MkjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fje2lEPTB;MD6xOlMxPiEQvF2= NXPpSYJ6W0GQR1XS
D-283MED MnnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;3PWlEPTB;MD6xO|Y5PiEQvF2= MUHTRW5ITVJ?
LU-135 MlzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPobWFKSzVyPUCuNVg2PTJizszN NGqyeHBUSU6JRWK=
LU-134-A MnrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;5PWJZUUN3ME2wMlE5PjdzIN88US=> M4\iOHNCVkeHUh?=
EM-2 MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTLTWM2OD1yLkG5PVE5KM7:TR?= NGO0dGZUSU6JRWK=
LU-139 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzUeVdKSzVyPUCuNlA1QThizszN NV71cJhQW0GQR1XS
ALL-PO M3:0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TaSGlEPTB;MD6yNVk5QCEQvF2= MVfTRW5ITVJ?
NB12 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMkOxNVUh|ryP M1\PWXNCVkeHUh?=
KP-N-YN M2KwcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDjd5RKSzVyPUCuNlM2PzNizszN NFWycIZUSU6JRWK=
BEN MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljXTWM2OD1yLkKzPVY5KM7:TR?= M{X2ZnNCVkeHUh?=
HCC1569 MmDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMkWxNFYh|ryP M1\YUnNCVkeHUh?=
HuO9 NF7FO4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHJNndKSzVyPUCuNlY4OTVizszN MkT4V2FPT0WU
WM-115 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMke3N|gh|ryP M{Drb3NCVkeHUh?=
CCRF-CEM MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n0cGlEPTB;MD6zN|UzQSEQvF2= MXrTRW5ITVJ?
IST-SL1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmn1TWM2OD1yLkO1N|Q{KM7:TR?= MkL1V2FPT0WU
BE-13 NW\sV2szT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jRbGlEPTB;MD6zOlQ2QSEQvF2= NVjGU2FzW0GQR1XS
COR-L88 NH\hTnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwM{[1OEDPxE1? MYPTRW5ITVJ?
DOHH-2 NHfWdYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEi1SpNKSzVyPUCuOFExOjNizszN MVfTRW5ITVJ?
A704 NITIN|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnVTWM2OD1yLkSyOlch|ryP MYnTRW5ITVJ?
KNS-81-FD M1ntOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17UfWlEPTB;MD60OFAyPyEQvF2= NIP6SpFUSU6JRWK=
RPMI-8226 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHYVItKSzVyPUCuOFU3PTJizszN M1T6XnNCVkeHUh?=
TGBC24TKB NVTWdYZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwNEW3O|gh|ryP NY\RUpBRW0GQR1XS
NCI-H1304 NIW4eHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rSfGlEPTB;MD60OlE2PyEQvF2= MUnTRW5ITVJ?
MOLT-13 MlLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M123SWlEPTB;MD60OlYyOyEQvF2= MUXTRW5ITVJ?
EW-22 Mo\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3nbnpEUUN3ME2wMlQ3PjdzIN88US=> M3PI[XNCVkeHUh?=
MS-1 NXfwdnh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37scWlEPTB;MD60Olk{OyEQvF2= NES1Z2pUSU6JRWK=
RMG-I NU\1Upo2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzOeWhkUUN3ME2wMlQ6PDZ2IN88US=> NX7sPZMxW0GQR1XS
NTERA-S-cl-D1 NGrPdoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHr5d4dKSzVyPUCuOVAxOTlizszN Mn6wV2FPT0WU
NCI-H1048 M1fVXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfFVm1KSzVyPUCuOVA6PTNizszN M2PLUHNCVkeHUh?=
SW1417 NFzxW25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXr6XGRDUUN3ME2wMlU2PDN6IN88US=> MVHTRW5ITVJ?
DB MkK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3u5NWlEPTB;MD61O|A5KM7:TR?= M4XOdnNCVkeHUh?=
MEG-01 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LFd2lEPTB;MD61PFMzKM7:TR?= NGnpXlVUSU6JRWK=
EW-13 NV[xc4NLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwNUizOFEh|ryP NEHsSVlUSU6JRWK=
LAMA-84 NYT1RotPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37CfWlEPTB;MD61PVIxPyEQvF2= M2K0fnNCVkeHUh?=
J-RT3-T3-5 NYn4UVFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXOVo91UUN3ME2wMlYxQDB6IN88US=> NXz6cmZvW0GQR1XS
MOLT-16 M33qXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwNkWyOlQh|ryP Mn\xV2FPT0WU
DU-4475 M3HoO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTy[Y03UUN3ME2wMlY2PDJ5IN88US=> NXzxRVI2W0GQR1XS
HAL-01 NU\LWIh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Hre2lEPTB;MD63NlU1QSEQvF2= MnzHV2FPT0WU
RD M3vkR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{O5dGlEPTB;MD63OVg6QSEQvF2= Mn;pV2FPT0WU
OAW-28 M3z5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoWyTWM2OD1yLke4N|ch|ryP MUfTRW5ITVJ?
HCC38 M1\ObWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\lWll1UUN3ME2wMlgxOTlizszN MlS2V2FPT0WU
NMC-G1 MmfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\lcWlEPTB;MD64NVEzOSEQvF2= M1K3cHNCVkeHUh?=
EW-16 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwOEGzNlgh|ryP MXPTRW5ITVJ?
DU-145 NWfBb5JET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTTTWM2OD1yLki5PVI{KM7:TR?= MmqwV2FPT0WU
HPAF-II NIjUXmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHL2PFVKSzVyPUCuPVI3OjhizszN NX[3O5ZvW0GQR1XS
A427 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjKXph1UUN3ME2wMlk{ODJ{IN88US=> NFzF[5BUSU6JRWK=
PA-1 NYT3fGk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPRc|VYUUN3ME2wMlk2PjR{IN88US=> NFLzZ4RUSU6JRWK=
OAW-42 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jyWmlEPTB;MD65OlE1PiEQvF2= M4jOenNCVkeHUh?=
L-428 M4TZb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrETWM2OD1zLkCxNlUh|ryP MV\TRW5ITVJ?
COLO-824 MknoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mme2TWM2OD1zLkCxO|A5KM7:TR?= NXPVfGVMW0GQR1XS
P30-OHK NV3ROpF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV30fnprUUN3ME2xMlA1Pjh6IN88US=> MlK4V2FPT0WU
NCI-H2170 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTFwME[yN{DPxE1? MkjHV2FPT0WU
HCC2998 NF7jR3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:zPWxZUUN3ME2xMlA4OTN3IN88US=> NEXac5RUSU6JRWK=
NB14 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfFTWJKSzVyPUGuNVM4PDhizszN MWfTRW5ITVJ?
TGBC1TKB NU\hRo1GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XnVWlEPTB;MT6xOFE2OiEQvF2= NVfmZ5dlW0GQR1XS
KP-N-YS MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlX2TWM2OD1zLkG2NlM3KM7:TR?= MXTTRW5ITVJ?
CAL-120 NHjsN4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn1TWM2OD1zLkG2OFI6KM7:TR?= Mk\UV2FPT0WU
SBC-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjuTI1KSzVyPUGuNVkxPTNizszN M1;uWHNCVkeHUh?=
C32 Mn7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITTdGpKSzVyPUGuNVkxQDhizszN NX\5R5A6W0GQR1XS
HCC2157 NVT2SoFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTFwMUm0PVQh|ryP M3nlU3NCVkeHUh?=
COLO-792 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLuR|l{UUN3ME2xMlIxODdzIN88US=> MXfTRW5ITVJ?
ES7 NVfoSJdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHGyNJpKSzVyPUGuNlc6PTFizszN NGPnT3pUSU6JRWK=
HEL MlHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrsdIV[UUN3ME2xMlMyODJ7IN88US=> NG\POXFUSU6JRWK=
ES4 M1LFU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTFwM{S5PVgh|ryP MX\TRW5ITVJ?
NCI-SNU-1 NIXnbXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml6wTWM2OD1zLkO2OVU2KM7:TR?= MoHjV2FPT0WU
MDA-MB-415 MlfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\Ze2Y{UUN3ME2xMlM5QDVizszN M2W0OHNCVkeHUh?=
NCI-H2342 NUj5fpVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\Ge3BIUUN3ME2xMlQxOjZ7IN88US=> MmLxV2FPT0WU
NB69 M1XESWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jGb2lEPTB;MT60OlI4OSEQvF2= MoDXV2FPT0WU
D-247MG MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTFwNUGxNlIh|ryP M36zU3NCVkeHUh?=
SCC-4 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXDT4VKSzVyPUGuOVk5QDdizszN MYnTRW5ITVJ?
HuH-7 Ml[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmmxTWM2OD1zLk[3Nlk{KM7:TR?= MYTTRW5ITVJ?
A388 NVzoc4w5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfITWM2OD1zLk[4O|I1KM7:TR?= NX3ZbYRkW0GQR1XS
Calu-3 NHT3foFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrHOm9zUUN3ME2xMlcxPjl5IN88US=> MYnTRW5ITVJ?
NCI-H1648 M1vCWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTFwN{G0NVgh|ryP MmjBV2FPT0WU
NCI-H2052 NF\NU|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTFwN{KyNFEh|ryP M1HGNnNCVkeHUh?=
Ramos-2G6-4C10 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;MVpJKSzVyPUGuO|M3PTZizszN M2KzW3NCVkeHUh?=
DEL MnvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrSZYZKSzVyPUGuO|Q3QTJizszN NEexVIdUSU6JRWK=
SNU-423 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTXcFlqUUN3ME2xMlc5OTV5IN88US=> NILDSGpUSU6JRWK=
COR-L23 NH[5eHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTFwN{m4O|Qh|ryP MWDTRW5ITVJ?
OMC-1 NIPMSnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTFwOE[wNVYh|ryP MlvPV2FPT0WU
EW-11 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDOTWM2OD1zLkm1OlU4KM7:TR?= MYrTRW5ITVJ?
HSC-3 NHjm[XlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDKTplJUUN3ME2xMlk3OzZ3IN88US=> Mm\0V2FPT0WU
MLMA M2O5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1qzfmlEPTB;MT65OlY4PyEQvF2= MULTRW5ITVJ?
RCM-1 NFTKU|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvZTWM2OD1{LkCwN|k6KM7:TR?= MV3TRW5ITVJ?
MFE-280 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;6OnNKSzVyPUKuNFI5PDhizszN NXvtOFNOW0GQR1XS
ES8 NF\0VJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHlVZh7UUN3ME2yMlI2PDdzIN88US=> MYDTRW5ITVJ?
TE-11 NUHuNFVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkK2TWM2OD1{LkK5OFc{KM7:TR?= M1:4RXNCVkeHUh?=
HuO-3N1 MoOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHuZmhKSzVyPUKuOFg4QCEQvF2= NF7EPGZUSU6JRWK=
MHH-NB-11 M1Prc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXvZmNKSzVyPUKuOVEyPThizszN M{jjdHNCVkeHUh?=
TGBC11TKB MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnL0TWM2OD1{LkW3OlgyKM7:TR?= M{H1VHNCVkeHUh?=
HOP-92 NFLBfVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTJwNUi3OFMh|ryP NYq1eZo5W0GQR1XS
IGR-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fuOWlEPTB;Mj62NlA{PSEQvF2= M1TkR3NCVkeHUh?=
GOTO NFjvcpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF34WHFKSzVyPUKuOlU{PzdizszN MnqwV2FPT0WU
NCI-H1650 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTJwN{KyNVUh|ryP M3;LTXNCVkeHUh?=
NCI-H1581 M2K3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlr0TWM2OD1{Lke5OlgyKM7:TR?= MWPTRW5ITVJ?
NCI-H2405 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTJwOEK3PFIh|ryP MV;TRW5ITVJ?
U-118-MG NXqxcFNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnXfotoUUN3ME2yMlk3PDlzIN88US=> M4HD[XNCVkeHUh?=
DoTc2-4510 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfaXXd3UUN3ME2zMlAyPDF5IN88US=> NYLUdopyW0GQR1XS
NCI-H596 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTNwMES5PVch|ryP NFTOTI5USU6JRWK=
MPP-89 MnLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnRTWM2OD1|LkC1OlY3KM7:TR?= NFTiZodUSU6JRWK=
GCIY M1uwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTNwMkC0PVEh|ryP NGDEdZNUSU6JRWK=
SW626 Mkf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXf0Too{UUN3ME2zMlI1PTR|IN88US=> M2nkN3NCVkeHUh?=
OCI-AML2 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTNwM{GyO|Ih|ryP MWDTRW5ITVJ?
NBsusSR M3vWTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjMTWM2OD1|LkO0PVM5KM7:TR?= NVrHOlh4W0GQR1XS
AN3-CA NUnsc41UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrX[G5sUUN3ME2zMlQ1OjN6IN88US=> M3mxeXNCVkeHUh?=
EFM-19 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrrTWM2OD1|LkS4N|M6KM7:TR?= NHrPb|ZUSU6JRWK=
RVH-421 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTNwNU[4O|ch|ryP M3;pRnNCVkeHUh?=
5637 NYrnRXo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorjTWM2OD1|Lk[xNVA{KM7:TR?= M4XGVHNCVkeHUh?=
PANC-08-13 MmLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTNwNkO0O|Ih|ryP NH\zeZdUSU6JRWK=
H9 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfI[2pKSzVyPUOuOlcyPDRizszN NUXrd5FOW0GQR1XS
KARPAS-299 NX;MVINIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTNwNkezOlEh|ryP MXrTRW5ITVJ?
TE-5 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXy5fWdGUUN3ME2zMlcxPzB7IN88US=> M{C3[HNCVkeHUh?=
NOS-1 NI\hZmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn76TWM2OD1|Lke5PFM1KM7:TR?= MnLnV2FPT0WU
HH NYTkUG83T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTNwOEO4Olgh|ryP NY\mVmhIW0GQR1XS
769-P NVeyVpV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTNwOEm1NUDPxE1? M3;SZ3NCVkeHUh?=
CHP-212 M1rSVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPqWmJYUUN3ME2zMlkzPTR7IN88US=> NH[5VJlUSU6JRWK=
NCI-H82 Mki3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTSTWM2OD1|Lkm1PVM3KM7:TR?= NIDuW2tUSU6JRWK=
Mo-T NFnOUHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTRwMESzNVIh|ryP MoDhV2FPT0WU
BB65-RCC M2\PO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\1fYJKSzVyPUSuNFQ{QTlizszN M1L3U3NCVkeHUh?=
SW1990 NHHNc41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmf2TWM2OD12LkC1PVA5KM7:TR?= MnrMV2FPT0WU
LK-2 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTRwMUGyPVMh|ryP M165RXNCVkeHUh?=
ES5 Ml;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HybGlEPTB;ND6xN|k5PSEQvF2= NGrXcI9USU6JRWK=
JVM-3 NH3mZmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrP[phnUUN3ME20MlE5OjJ{IN88US=> MkG3V2FPT0WU
RPMI-7951 MkC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2q5XWlEPTB;ND6yNlQyOyEQvF2= NVe5WmhOW0GQR1XS
Calu-6 NEDO[WZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXUUWl2UUN3ME20MlI4QDhzIN88US=> MVLTRW5ITVJ?
LC-2-ad MkXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHzO4lkUUN3ME20MlI6PTZ6IN88US=> MlTQV2FPT0WU
SW954 M1XpS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TrVGlEPTB;ND6yPVY3KM7:TR?= M3;JSXNCVkeHUh?=
H-EMC-SS NETMR41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;DTWM2OD12LkOxPFMyKM7:TR?= M3Xhe3NCVkeHUh?=
ES3 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rvWmlEPTB;ND6zOVQ1OSEQvF2= M{TVOHNCVkeHUh?=
no-11 NIDmR|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHLfG1KSzVyPUSuN|U2PTRizszN NF;pUXNUSU6JRWK=
LAN-6 NVzRcG1LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\STWM2OD12LkS1NVg6KM7:TR?= MUDTRW5ITVJ?
FTC-133 M3nzNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTrTWM2OD12LkWzPVUh|ryP MW\TRW5ITVJ?
8505C Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrJTWM2OD12LkW0NlMh|ryP MUTTRW5ITVJ?
SW620 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTRwNUewOVch|ryP NWLVdmxIW0GQR1XS
BCPAP NUXDNHB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPLfnZKSzVyPUSuOlM1QDFizszN MUPTRW5ITVJ?
SK-LU-1 MkLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrvR2tKSzVyPUSuOlYxQDlizszN MoHGV2FPT0WU
NCI-H1623 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HS[WlEPTB;ND63NFIzQCEQvF2= MXHTRW5ITVJ?
C2BBe1 M3zCcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\5SmlEPTB;ND63OFAxQCEQvF2= MmTLV2FPT0WU
GP5d M1y3Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXvWZRXUUN3ME20Mlc5Ozh6IN88US=> MmXDV2FPT0WU
NB6 NG\Jd5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXmWZVtUUN3ME20Mlg3OjB2IN88US=> Ml:3V2FPT0WU
MDA-MB-157 NEHj[|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\yOXN5UUN3ME20Mlg5PzZizszN Mli0V2FPT0WU
UMC-11 NF3o[|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXjb5lHUUN3ME20Mlg5QTZ2IN88US=> MnLwV2FPT0WU
HCC1419 MkPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPNW|UyUUN3ME20MlkxODZ|IN88US=> MXfTRW5ITVJ?
NCI-H2029 NVzOeVRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfvTWM2OD12Lkm0NVg2KM7:TR?= MkLIV2FPT0WU
LXF-289 NH7UWIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXjTWM2OD13LkCzO|E6KM7:TR?= NWDsNopqW0GQR1XS
KINGS-1 NG\aNI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LpOGlEPTB;NT6wO|c1PCEQvF2= NXvVU3p4W0GQR1XS
HD-MY-Z NVX0VnpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nPTWlEPTB;NT6yN|k3QSEQvF2= M{G3OHNCVkeHUh?=
ESS-1 NFLYXoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHf3SFZKSzVyPUWuNlU2QTdizszN Ml[5V2FPT0WU
GI-1 NXjYOZBFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[wV3NEUUN3ME21MlI4QTJ4IN88US=> MlXmV2FPT0WU
RPMI-2650 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPZTWM2OD13LkO2NVYh|ryP NUjRc41jW0GQR1XS
IA-LM NWfneIxOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXVSZA2UUN3ME21MlM6QDdzIN88US=> NVLL[3Z[W0GQR1XS
KP-4 NHnVdY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1K2SmlEPTB;NT60OlM{PCEQvF2= Moq0V2FPT0WU
G-402 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTVwNUG4OlUh|ryP M4W3WXNCVkeHUh?=
OS-RC-2 Mo\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[xTHF2UUN3ME21MlUzPjB2IN88US=> MYXTRW5ITVJ?
NCI-H1155 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojITWM2OD13LkW0PVU2KM7:TR?= NIPCb5FUSU6JRWK=
OE19 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT0TWM2OD13Lk[4OlI1KM7:TR?= MVHTRW5ITVJ?
U-2-OS M1\sOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPvWmM1UUN3ME21Mlg6ODF|IN88US=> M2PUTnNCVkeHUh?=
SCC-15 MmDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTVwOUO2OlIh|ryP MkPZV2FPT0WU
NCI-H630 MmPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jhVWlEPTB;NT65PVQxPCEQvF2= Moj4V2FPT0WU
PFSK-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTZwMEWyOVkh|ryP MoLtV2FPT0WU
NCI-H1770 NHLsOGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLGVWVKSzVyPU[uNlA5PzRizszN M1\uVHNCVkeHUh?=
SK-MEL-3 NYfm[mRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTZwNEK5NVUh|ryP NV\SOHg3W0GQR1XS
LB1047-RCC NFK1RmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIOwdmVKSzVyPU[uOFc3OjVizszN MkPUV2FPT0WU
NCI-H446 M37qcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUO3eFRrUUN3ME22MlYzQTJ3IN88US=> MmC0V2FPT0WU
SW780 NI\0VpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DNTmlEPTB;Nj63NFE5PSEQvF2= NHLBTVRUSU6JRWK=
NEC8 NUHpWFh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHK4bXNKSzVyPU[uO|Y3OyEQvF2= MWDTRW5ITVJ?
NOMO-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1qwPGlEPTB;Nj63PFEyOSEQvF2= NXLCUJNRW0GQR1XS
COLO-668 MmfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTIZYZGUUN3ME22Mlg1Ozh5IN88US=> MWjTRW5ITVJ?
MC116 NHi4e29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTZwOUO4PVch|ryP MXjTRW5ITVJ?
HCC1937 MoXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjxcJVKSzVyPU[uPVkzPTFizszN M3r5XXNCVkeHUh?=
NCI-N87 M2S4WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XyOWlEPTB;Nz6xPVI6OyEQvF2= MoDVV2FPT0WU
COLO-320-HSR NYruTFQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXWfJQxUUN3ME23MlIzPzN6IN88US=> M1:ybnNCVkeHUh?=
HCC1806 MnvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTdwMk[wOFQh|ryP NHq0XYVUSU6JRWK=
OVCAR-3 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljITWM2OD15LkOzNFM5KM7:TR?= Mlm2V2FPT0WU
NUGC-3 M4[yPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;NZ2lEPTB;Nz6zPVY6PCEQvF2= MlHzV2FPT0WU
SW1783 NGTUOldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzPTWM2OD15LkSzNVc2KM7:TR?= MYfTRW5ITVJ?
GCT M1H2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHCVIliUUN3ME23MlU3QTB4IN88US=> NV;LUJh3W0GQR1XS
NCI-H2126 NVfueXA2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jjWmlEPTB;Nz63N|YzPSEQvF2= M{e0XHNCVkeHUh?=
MEL-HO M1Lub2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\uUVA3UUN3ME23Mlc4ODV2IN88US=> M1LNXXNCVkeHUh?=
CAPAN-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDFOHJ[UUN3ME23Mlc4OzV5IN88US=> MkjlV2FPT0WU
SW756 NH\rOGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLYWZlqUUN3ME23Mlc5OzN|IN88US=> MnnrV2FPT0WU
SKG-IIIa NHfPb2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTdwOEG4PVIh|ryP MmXFV2FPT0WU
HCE-T NX\kXo03T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLESG9{UUN3ME23Mlg4Pzh|IN88US=> MnuwV2FPT0WU
Ca-Ski MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXDTWM2OD15Lkm5N|g{KM7:TR?= M1T6V3NCVkeHUh?=
COLO-684 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jaeGlEPTB;OD6wNVgyQCEQvF2= NV20TVdTW0GQR1XS
KYSE-70 NI\B[phIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTXTWM2OD16LkC3O|I6KM7:TR?= MYfTRW5ITVJ?
TI-73 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonyTWM2OD16LkK1PFUyKM7:TR?= M{HjWXNCVkeHUh?=
BT-20 NX7udmpnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjh[FhKSzVyPUiuNlYxPTJizszN NXnSNGJGW0GQR1XS
MHH-ES-1 NFy5XINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnWWopzUUN3ME24MlUyQDN2IN88US=> M1K2[HNCVkeHUh?=
TE-12 MnTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3hTWM2OD16LkW5PVMyKM7:TR?= MkfPV2FPT0WU
YH-13 NIKzN5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XZO2lEPTB;OD62NVAxQCEQvF2= NVrJbJlvW0GQR1XS
SF126 M2m5Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7jXXpLUUN3ME24Mlg{QDZ3IN88US=> M2jIZ3NCVkeHUh?=
J82 NX\3dJhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2qyRWlEPTB;OD65NFA{QCEQvF2= NXTuUGlnW0GQR1XS
RCC10RGB M1jYVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3q0WmlEPTB;OD65PVU3OSEQvF2= NUfiNm9NW0GQR1XS
SK-UT-1 NXTPZ5k1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mle2TWM2OD17LkC0PVQ2KM7:TR?= Ml3YV2FPT0WU
LB2241-RCC Mof6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTlwMUmxN|ch|ryP M36wZ3NCVkeHUh?=
LB996-RCC Mm\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nwcWlEPTB;OT6xPVg6KM7:TR?= Ml;aV2FPT0WU
EPLC-272H NGTN[4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnuTWM2OD17LkO3OlU4KM7:TR?= MYPTRW5ITVJ?
CTV-1 NGH4dZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnIZ3lKSzVyPUmuOVY2OzJizszN MYfTRW5ITVJ?
HSC-2 MmSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTlwNUe1OUDPxE1? NFfhbYpUSU6JRWK=
SK-MEL-28 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPPO2hKSzVyPUmuOlE5QTNizszN MnPYV2FPT0WU
MMAC-SF MoG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\FdWNXUUN3ME25MlY5PzVizszN NYS3WIloW0GQR1XS
CP50-MEL-B MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\LeoZXUUN3ME25Mlc2Pzh{IN88US=> NFnjb2pUSU6JRWK=
HT-1080 NW\ocXRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPsTWM2OD17Lke3O|M6KM7:TR?= Mn35V2FPT0WU
HEC-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TEbGlEPTB;MUCuN|M2OiEQvF2= NUHzemp1W0GQR1XS
AGS Mmq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XjV2lEPTB;MUCuN|c1KM7:TR?= M3LO[XNCVkeHUh?=
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A204 NHrOclVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{SwR2lEPTB;NEKuOlM5QCEQvF2= MnXLV2FPT0WU
Saos-2 NFrsXYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnqPXJKSzVyPUSyMlg{PjlizszN M1jxOHNCVkeHUh?=
SNU-C2B M3judGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjmZlc{UUN3ME20N{43QDd6IN88US=> NWfjNZNZW0GQR1XS
HLE M{O1O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXGTWM2OD12ND6wPFU3KM7:TR?= NHL1fYxUSU6JRWK=
SW1463 M3XwWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWD4RZk2UUN3ME20OE46QTdzIN88US=> NGLhNJRUSU6JRWK=
DSH1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTR3LkCwN|Mh|ryP NWXnZ49pW0GQR1XS
MCF7 NYrjSJZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTR3LkWwOVEh|ryP MV;TRW5ITVJ?
K5 Mm\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTR3Lkm0NFUh|ryP M4PqcHNCVkeHUh?=
NCI-H358 NHnhN2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjYWnRKSzVyPUS3MlIyPSEQvF2= MVTTRW5ITVJ?
NCI-H2030 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTR5LkKzO|Qh|ryP NUnnSXF[W0GQR1XS
SW948 MmTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHURWVKSzVyPUS3MlQ3PCEQvF2= NXfKW3J6W0GQR1XS
BALL-1 NFO0dGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LGTGlEPTB;NEeuOlE3QCEQvF2= NInMcHBUSU6JRWK=
TE-9 M{TDb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTITWM2OD12Nz65OVgyKM7:TR?= MlziV2FPT0WU
SK-N-FI MoLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPkU3ZKSzVyPUS4MlA{PThizszN MonGV2FPT0WU
KALS-1 NH\K[m1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFf0fIRKSzVyPUS4MlEzQDlizszN Mlj2V2FPT0WU
HO-1-N-1 MmHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTR6Lke0OFUh|ryP MonlV2FPT0WU
NCI-H2452 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUiz[YdWUUN3ME20PU4yOTV{IN88US=> MV;TRW5ITVJ?
OC-314 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTR7Lk[4N|Qh|ryP M{K3SXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
STAT3 / pSTAT3 / STAT6 / pSTAT6 / Mcl-1 / Cleaved Mcl-1 / Bcl-xl / Bim / puma / Bik / Bax / PARP / c-Myc; 

PubMed: 26811457     


(A) Western blot analysis of expressions of STAT3/p-STAT3 and STAT6/p-STAT6 as well as antiapoptotic members (Bcl-2, Bcl-xL, and Mcl-1) after 48 h of treatments in HDLM-2 cells. (B) Western blot analysis of expressions of proapoptotic proteins (Bim, Puma, Bik, Bax, and p-Bad) as well as caspase cascade molecules (PARP and c-Myc) after 48 h of treatments. β-Actin was used as an input control.

caspase3 / cleaved caspase 3; 

PubMed: 24481442     


(b) (i) N/TERT, (ii) SINCE and (iii) SINEG2 cells were either untreated (0 μM/DMSO) or treated with increasing doses of Navitoclax (ABT-263; 0.025–30 μM) and were incubated for 24 h. Next, cells were collected and whole-cell lysates were prepared and immunoblotted against anti-full-length Caspase 3 (∼35 kDa) antibody, whereas β-actin (∼42 kDa) was used as a protein-loading control. Apoptosis was assessed through detecting the cleaved bands of Caspase-3 (∼19, 17 kDa). 

26811457 24481442
Growth inhibition assay
Cell viability; 

PubMed: 25685063     


(C) Hcc827, (D) H292, and (E) H1993 cells were treated with increasing concentrations of albendazole or mebendazole in the presence of navitoclax (0, 1, 2, and 4 μM). Viability was determined after 1 day.

25685063
体内研究 用ABT-263处理H345移植瘤模型,按动物体重,每千克每天处理10mg ABT-263,结果肿瘤生长抑制率达80% ,肿瘤体积减小了50%以上,显示出ABT-263极强的抗癌效果。ABT-263作用于非小细胞肺癌和急性淋巴细胞白血病的移植瘤模型时,每天单独口服,结果显示肿瘤完全衰退。ABT-263单独作用于B-细胞淋巴瘤和多发性骨髓瘤的移植瘤模型时效果不明显,但是可以显著增强临床其他相关用药的药性。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

+ 展开

激酶实验:

用竞争性荧光偏振检测测定ABT-263 作用于Bcl-2 家族不同亚型的Ki值或者IC50值。使用如下的肽探针对或者蛋白对:f-bad (1 nM) 和Bcl-xL (6 nM), f-Bax (1 nM) 和Bcl-2 (10 nM), f-Bax (1 nM) 和Bcl-w (40 nM), f-Noxa (2 nM)和Mcl-1 (40 nM), 及f-Bax (1 nM) 和Bcl-2-A1 (15 nM)。用时间分辨荧光共振能转移法测定ABT-263和Bcl-xL作用的结合紧密度。1 nM 用His标记的Bcl-xL 与200 nM f-Bak,及 1 nM Tb标记的His抗体混合, 然后在室温下处理30分钟。
细胞实验:

[1]

+ 展开
  • Cell lines: SCLC 细胞系
  • Concentrations: 0-1 μM
  • Incubation Time: 48小时
  • Method:

    人类肿瘤细胞系在37oC 含5% CO2环境下获得,SCLC 细胞系培养在RPMI 1640培养基中,培养基包含10% 胎牛血清, 1% 丙酮酸钠, 25 mM HEPES, 4.5 g/L葡萄糖, 1% 青霉素/链霉素。用含有10% FBS和1% 青霉素/链霉素的RPMI 1640培养基培养白血病和淋巴癌细胞系。细胞在96孔板上处理48小时,最终体积达到100ul。在体外测试ABT-263的细胞毒性。


    (Only for Reference)
动物实验:

[1]

+ 展开
  • Animal Models: C.B.-17严重联合免疫缺陷-米黄鼠
  • Formulation: ABT-263在10% 乙醇, 30% 聚乙二醇400, 及60% Phosal 50 PG中制成
  • Dosages: 100 mg/kg/d
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (102.6 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+corn oil
7mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 974.61
化学式

C47H55ClF3N5O6S3

CAS号 923564-51-6
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03366103 Recruiting Metastatic Malignant Solid Neoplasm|Recurrent Malignant Solid Neoplasm|Recurrent Small Cell Lung Carcinoma|Stage III Small Cell Lung Carcinoma AJCC v7|Stage IIIA Small Cell Lung Carcinoma AJCC v7|Stage IIIB Small Cell Lung Carcinoma AJCC v7|Stage IV Lung Small Cell Carcinoma AJCC v7|Unresectable Solid Neoplasm National Cancer Institute (NCI) November 29 2017 Phase 1|Phase 2
NCT03181126 Recruiting Acute Lymphoblastic Leukemia (ALL)|Lymphoblastic Lymphoma AbbVie November 27 2017 Phase 1
NCT03366103 Recruiting Metastatic Malignant Solid Neoplasm|Recurrent Malignant Solid Neoplasm|Recurrent Small Cell Lung Carcinoma|Stage III Small Cell Lung Carcinoma AJCC v7|Stage IIIA Small Cell Lung Carcinoma AJCC v7|Stage IIIB Small Cell Lung Carcinoma AJCC v7|Stage IV Lung Small Cell Carcinoma AJCC v7|Unresectable Solid Neoplasm National Cancer Institute (NCI) November 29 2017 Phase 1|Phase 2
NCT03181126 Recruiting Acute Lymphoblastic Leukemia (ALL)|Lymphoblastic Lymphoma AbbVie November 27 2017 Phase 1
NCT03222609 Recruiting Myelofibrosis (MF) AbbVie October 31 2017 Phase 2
NCT03222609 Recruiting Myelofibrosis (MF) AbbVie October 31 2017 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    I would like to deliver S1001 via i.p. injection, can you suggest a vehicle solution?

  • 回答:

    S1001 ABT-263 (Navitoclax) can be dissolved in 5% DMSO+corn oil at 7mg/ml as a clear solution.

  • 问题 2:

    Could you tell me if the catalog number S1001 can go through the hemato-encephalic barrier?

  • 回答:

    According to the paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223694/, ABT-263 can not cross brain-blood barrier.

Bcl-2 Signaling Pathway Map

Bcl-2 Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID