Navitoclax (ABT-263)

For research use only. Not for use in humans.

目录号:S1001

Navitoclax (ABT-263) Chemical Structure

Molecular Weight(MW): 974.61

Navitoclax (ABT-263)是一种有效的Bcl-xLBcl-2Bcl-w抑制剂,无细胞试验中Ki分别为≤0.5 nM,≤1 nM和≤1 nM,但与Mcl-1和A1结合微弱。Phase 2。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 3285.53 现货
RMB 975.71 现货
RMB 1631.61 现货
RMB 3016.58 现货
RMB 7950.36 现货
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客户使用Selleck生产的Navitoclax (ABT-263)发表文献158篇:

产品安全说明书

Bcl-2抑制剂选择性比较

生物活性

产品描述 Navitoclax (ABT-263)是一种有效的Bcl-xLBcl-2Bcl-w抑制剂,无细胞试验中Ki分别为≤0.5 nM,≤1 nM和≤1 nM,但与Mcl-1和A1结合微弱。Phase 2。
靶点
Bcl-xL [1]
(Cell-free assay)
Bcl-2 [1]
(Cell-free assay)
Bcl-w [1]
(Cell-free assay)
<=0.5 nM(Ki) <=1 nM(Ki) <=1 nM(Ki)
体外研究

ABT-263有效抑制Bcl-2蛋白家族,用荧光偏振分析法测试ABT-263作用于Bcl-xL, Bcl-2和 Bcl-w时,Ki分别为0.5, 1和1 nM。[1]ABT-263结构上与ABT-737相关。ABT-263阻断Bcl-2 和Bcl-XL与凋亡前体蛋白相互作用。Bcl-2家族成员Bcl-2,Bcl-XL, 和Mcl-1的过量表达通常都与肿瘤的修复及抗药性有关。ABT-263作用于过量表达的Bcl-2 和Bcl-XL时显示出保护作用,EC50分别为60 和20 nM。ABT-263作用于不同的细胞显示出不同的细胞活性,作用于H146细胞系时EC50为110nM,而作用于H82细胞系时EC50为22 µM。ABT-737可以有效作用于四种EC50值 <400 nM的细胞系,即H146, H889, H1963, 和H1417。而两种抗ABT-737的细胞系,即H1048和H82,同样也显示出抗ABT-263的特性。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell M2jFSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfQTWM2OD1yLkCwOlY6KM7:TR?= MlPtV2FPT0WU
MV-4-11 M1;kS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzJTWM2OD1yLkCxOVg3KM7:TR?= NUnvRmcyW0GQR1XS
NKM-1 M{LrbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;HPGlEPTB;MD6wNVY6QSEQvF2= NGLC[4FUSU6JRWK=
ML-2 MmruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjqeWFbUUN3ME2wMlAyQTh|IN88US=> NGnxRo1USU6JRWK=
BV-173 NF7S[G9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMEKzNVQh|ryP NGrBPFdUSU6JRWK=
RS4-11 NGPod4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17udGlEPTB;MD6wNlU5PyEQvF2= M{jOZ3NCVkeHUh?=
HL-60 NF;FdJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzybFlKSzVyPUCuNFI6ODhizszN MkTtV2FPT0WU
KY821 MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3zWXZKSzVyPUCuNFI6PzVizszN M3ezZnNCVkeHUh?=
ECC10 NWq4RWM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFm4XFBKSzVyPUCuNFM4QTJizszN NED3S5pUSU6JRWK=
NCI-H720 NX:1UmtnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlryTWM2OD1yLkC0NFEyKM7:TR?= MUnTRW5ITVJ?
QIMR-WIL MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3SxWmlEPTB;MD6wOFI5PyEQvF2= NWf2THcxW0GQR1XS
KG-1 NIXuNmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYr1So5wUUN3ME2wMlA1PDh4IN88US=> M1LVSXNCVkeHUh?=
TGW MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXW3fmNSUUN3ME2wMlA1PjN|IN88US=> MnzsV2FPT0WU
ATN-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPyTWM2OD1yLkC0O|M{KM7:TR?= MmG4V2FPT0WU
RH-18 NVjZ[GJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTzTWM2OD1yLkC2NFQ5KM7:TR?= M{HxfHNCVkeHUh?=
EW-18 M{Hx[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGC0TnJKSzVyPUCuNFY5PDFizszN M1rRU3NCVkeHUh?=
NB17 MorlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3Z[|h{UUN3ME2wMlA4OTJ2IN88US=> MWLTRW5ITVJ?
SK-NEP-1 MlHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVSxUIFJUUN3ME2wMlA4OjF|IN88US=> M4n4VXNCVkeHUh?=
P12-ICHIKAWA NUTEfooyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfQeHdVUUN3ME2wMlA4Pzd6IN88US=> NW\tXIZWW0GQR1XS
KARPAS-45 MniyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMEe4NVUh|ryP M2jDRnNCVkeHUh?=
EW-3 M2f4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjJVWNKSzVyPUCuNFgxPTNizszN M3\yR3NCVkeHUh?=
NB13 M3XEeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonBTWM2OD1yLkC4NlA{KM7:TR?= MmC0V2FPT0WU
NCI-H209 NHfzPYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrRcXhKSzVyPUCuNFg4ODRizszN MmflV2FPT0WU
NCI-H1092 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMUCyO|Uh|ryP NHzpV3NUSU6JRWK=
NH-12 NVLXbFV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4X4emlEPTB;MD6xNFc1PCEQvF2= M4\DNnNCVkeHUh?=
697 M4HLR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XEdmlEPTB;MD6xNFg{QSEQvF2= MY\TRW5ITVJ?
KE-37 NFqyUGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHwTWM2OD1yLkGxN|ch|ryP M1;yfXNCVkeHUh?=
MOLT-4 NYDlPZc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHKfJl6UUN3ME2wMlE2OTZ7IN88US=> M2DDNHNCVkeHUh?=
CHP-134 M2HG[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXKPJJKSzVyPUCuNVY{ODZizszN NFLMW4VUSU6JRWK=
D-283MED MnjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMUe2PFYh|ryP NIX6dFFUSU6JRWK=
LU-135 NEfscGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMUi1OVIh|ryP MojDV2FPT0WU
LU-134-A NWPEOI42T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELUW3RKSzVyPUCuNVg3PzFizszN M3nqfnNCVkeHUh?=
EM-2 MlvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HLeGlEPTB;MD6xPVkyQCEQvF2= MXjTRW5ITVJ?
LU-139 NELjSIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHNRoRUUUN3ME2wMlIxPDl6IN88US=> NWP1Zpk1W0GQR1XS
ALL-PO M2jocWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnne|ZtUUN3ME2wMlIyQTh6IN88US=> M{PrXnNCVkeHUh?=
NB12 Mlv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULTfoRWUUN3ME2wMlI{OTF3IN88US=> NU\xVW4{W0GQR1XS
KP-N-YN MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3RXJJKSzVyPUCuNlM2PzNizszN NHqzU|RUSU6JRWK=
BEN NUjRPFVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NED6RlVKSzVyPUCuNlM6PjhizszN NFL6Z5RUSU6JRWK=
HCC1569 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG[5W4tKSzVyPUCuNlUyODZizszN NVvzRZJkW0GQR1XS
HuO9 NEjadmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPVTWM2OD1yLkK2O|E2KM7:TR?= MYrTRW5ITVJ?
WM-115 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEm5d2RKSzVyPUCuNlc4OzhizszN M{LPcHNCVkeHUh?=
CCRF-CEM M3XIO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwM{O1Nlkh|ryP NVnZbXFoW0GQR1XS
IST-SL1 NUPjOo9zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjkNG9XUUN3ME2wMlM2OzR|IN88US=> M3LxOHNCVkeHUh?=
BE-13 NHizZXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLFc4VKSzVyPUCuN|Y1PTlizszN MoTBV2FPT0WU
COR-L88 NGe1PYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\WTWM2OD1yLkO2OVQh|ryP M2i1WHNCVkeHUh?=
DOHH-2 M2TUSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHPTWM2OD1yLkSxNFI{KM7:TR?= NIHCTm9USU6JRWK=
A704 NYnGZo1{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXOfId6UUN3ME2wMlQzPjdizszN M2nSVnNCVkeHUh?=
KNS-81-FD NFfIc3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwNESwNVch|ryP Mnj1V2FPT0WU
RPMI-8226 MlT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLySHdDUUN3ME2wMlQ2PjV{IN88US=> MUDTRW5ITVJ?
TGBC24TKB NXXCS2JpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwNEW3O|gh|ryP NWnTNoc2W0GQR1XS
NCI-H1304 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTWNoM6UUN3ME2wMlQ3OTV5IN88US=> M2fZ[XNCVkeHUh?=
MOLT-13 MnSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLHTWM2OD1yLkS2OlE{KM7:TR?= MVLTRW5ITVJ?
EW-22 NGPYUZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfITWM2OD1yLkS2OlcyKM7:TR?= NVXkbVhTW0GQR1XS
MS-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfvSWFKSzVyPUCuOFY6OzNizszN NYDtfpNjW0GQR1XS
RMG-I M1\0Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwNEm0OlQh|ryP MnnMV2FPT0WU
NTERA-S-cl-D1 M3TNNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGizS|BKSzVyPUCuOVAxOTlizszN M2\JUHNCVkeHUh?=
NCI-H1048 NWG4doc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwNUC5OVMh|ryP MnPtV2FPT0WU
SW1417 NUTDdZNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{n2XmlEPTB;MD61OVQ{QCEQvF2= MoTjV2FPT0WU
DB NYPk[oFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvHb2ZKSzVyPUCuOVcxQCEQvF2= Mkn0V2FPT0WU
MEG-01 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{[4OGlEPTB;MD61PFMzKM7:TR?= M4nsPHNCVkeHUh?=
EW-13 M1[5TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfGOWZKSzVyPUCuOVg{PDFizszN M3nDdXNCVkeHUh?=
LAMA-84 NWPNe4JMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Ps[2lEPTB;MD61PVIxPyEQvF2= NUTseIxEW0GQR1XS
J-RT3-T3-5 M{Ph[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jRV2lEPTB;MD62NFgxQCEQvF2= NV:xcpJMW0GQR1XS
MOLT-16 NXnhVZFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHVPW5KSzVyPUCuOlUzPjRizszN M4rxXXNCVkeHUh?=
DU-4475 M2DJOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGezSJdKSzVyPUCuOlU1OjdizszN NWHUUVl7W0GQR1XS
HAL-01 MlTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{CzdmlEPTB;MD63NlU1QSEQvF2= NYDKUnpRW0GQR1XS
RD NXOxcVVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwN{W4PVkh|ryP M2PpRnNCVkeHUh?=
OAW-28 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3vT3lKSzVyPUCuO|g{PyEQvF2= MkfxV2FPT0WU
HCC38 MkLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfCdYdKSzVyPUCuPFAyQSEQvF2= Ml3DV2FPT0WU
NMC-G1 M4m4[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnhc|FpUUN3ME2wMlgyOTJzIN88US=> NGXHcHhUSU6JRWK=
EW-16 NVnwcG0yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLaTWM2OD1yLkixN|I5KM7:TR?= NUDnZWZsW0GQR1XS
DU-145 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\HTWM2OD1yLki5PVI{KM7:TR?= NXrQcWhqW0GQR1XS
HPAF-II MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwOUK2Nlgh|ryP NU[5SGk5W0GQR1XS
A427 MlfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\G[GlEPTB;MD65N|AzOiEQvF2= MUXTRW5ITVJ?
PA-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFm4bZJKSzVyPUCuPVU3PDJizszN NHjSTGZUSU6JRWK=
OAW-42 NILIXnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFr2fnpKSzVyPUCuPVYyPDZizszN NXHOe3VyW0GQR1XS
L-428 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTFwMEGyOUDPxE1? NHzB[2ZUSU6JRWK=
COLO-824 M1TJb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnMb5lKSzVyPUGuNFE4ODhizszN MUHTRW5ITVJ?
P30-OHK MnPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTZW|N7UUN3ME2xMlA1Pjh6IN88US=> NYPneJR5W0GQR1XS
NCI-H2170 NUPBNYp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTFwME[yN{DPxE1? M2DZd3NCVkeHUh?=
HCC2998 NVvkSXlST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHz3RWRKSzVyPUGuNFcyOzVizszN NYPOeVV6W0GQR1XS
NB14 M2fYfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfnTWxKSzVyPUGuNVM4PDhizszN Mlm4V2FPT0WU
TGBC1TKB M4ez[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDscIY4UUN3ME2xMlE1OTV{IN88US=> Mn;FV2FPT0WU
KP-N-YS M3\4eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3:xNGlEPTB;MT6xOlI{PiEQvF2= NHvneY9USU6JRWK=
CAL-120 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fyZmlEPTB;MT6xOlQzQSEQvF2= NGXJZ4hUSU6JRWK=
SBC-1 MkDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\jXFRKSzVyPUGuNVkxPTNizszN M1fJ[nNCVkeHUh?=
C32 NFOwfGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTFwMUmwPFgh|ryP MknrV2FPT0WU
HCC2157 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTFwMUm0PVQh|ryP NUnOVXVMW0GQR1XS
COLO-792 NHm0ZW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS0VY5ZUUN3ME2xMlIxODdzIN88US=> NYj4WY4zW0GQR1XS
ES7 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\lTmhKSzVyPUGuNlc6PTFizszN MWLTRW5ITVJ?
HEL NYTEOIpuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFmyTHpKSzVyPUGuN|ExOjlizszN Mlq1V2FPT0WU
ES4 MmLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTFwM{S5PVgh|ryP NV3rTVc6W0GQR1XS
NCI-SNU-1 NWL2fG1rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTFwM{[1OVUh|ryP M2LMe3NCVkeHUh?=
MDA-MB-415 NHTP[HZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTFwM{i4OUDPxE1? NGeyc4lUSU6JRWK=
NCI-H2342 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjjd4ZEUUN3ME2xMlQxOjZ7IN88US=> M1G0dnNCVkeHUh?=
NB69 NIDQRYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHT4dYhKSzVyPUGuOFYzPzFizszN MnPwV2FPT0WU
D-247MG MlzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTWTWM2OD1zLkWxNVIzKM7:TR?= MnriV2FPT0WU
SCC-4 NWjEOppYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF76Sm1KSzVyPUGuOVk5QDdizszN M{PjUnNCVkeHUh?=
HuH-7 NX3Sb2ExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrzTWM2OD1zLk[3Nlk{KM7:TR?= NWCwXYFuW0GQR1XS
A388 MlG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkH6TWM2OD1zLk[4O|I1KM7:TR?= Mkn2V2FPT0WU
Calu-3 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTFwN{C2PVch|ryP NYfWU5ZRW0GQR1XS
NCI-H1648 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r5WWlEPTB;MT63NVQyQCEQvF2= NF:5dG5USU6JRWK=
NCI-H2052 NGfzZ2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPZTWM2OD1zLkeyNlAyKM7:TR?= MVXTRW5ITVJ?
Ramos-2G6-4C10 Mn3JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrBRmhKSzVyPUGuO|M3PTZizszN NEO3V41USU6JRWK=
DEL MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDZdWJKSzVyPUGuO|Q3QTJizszN MoTQV2FPT0WU
SNU-423 M4XrPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjsOlBKSzVyPUGuO|gyPTdizszN MknrV2FPT0WU
COR-L23 NWWwZ4tMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPIfnVKSzVyPUGuO|k5PzRizszN Mni4V2FPT0WU
OMC-1 NWrXW4VpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HNcmlEPTB;MT64OlAyPiEQvF2= MofwV2FPT0WU
EW-11 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTFwOUW2OVch|ryP NF3ldoZUSU6JRWK=
HSC-3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTMSWlCUUN3ME2xMlk3OzZ3IN88US=> NIHIVVZUSU6JRWK=
MLMA NU\LVZQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfLVYJKSzVyPUGuPVY3PzdizszN NH3qb3JUSU6JRWK=
RCM-1 NXLQbmFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2C0WmlEPTB;Mj6wNFM6QSEQvF2= NWnLPWF3W0GQR1XS
MFE-280 M1yyfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTJwMEK4OFgh|ryP M3jQc3NCVkeHUh?=
ES8 NEnDSHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTJwMkW0O|Eh|ryP NHHMRpJUSU6JRWK=
TE-11 Mnm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTVUY1TUUN3ME2yMlI6PDd|IN88US=> Mo[5V2FPT0WU
HuO-3N1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILkPW9KSzVyPUKuOFg4QCEQvF2= NWDZfFFFW0GQR1XS
MHH-NB-11 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LnfGlEPTB;Mj61NVE2QCEQvF2= NFLHbW9USU6JRWK=
TGBC11TKB NV3abVZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3NZ4hKSzVyPUKuOVc3QDFizszN Ml36V2FPT0WU
HOP-92 MkPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7lSlRKSzVyPUKuOVg4PDNizszN NX3KdodUW0GQR1XS
IGR-1 NFXVfm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDVTWM2OD1{Lk[yNFM2KM7:TR?= NYjzXGVTW0GQR1XS
GOTO MoryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjlUHNKSzVyPUKuOlU{PzdizszN MmHtV2FPT0WU
NCI-H1650 M3npNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\KNIZ{UUN3ME2yMlczOjF3IN88US=> MmeyV2FPT0WU
NCI-H1581 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTJwN{m2PFEh|ryP MlPxV2FPT0WU
NCI-H2405 NVPqNXcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTJwOEK3PFIh|ryP NFLxZohUSU6JRWK=
U-118-MG NGC4d2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHadIQ3UUN3ME2yMlk3PDlzIN88US=> M13i[XNCVkeHUh?=
DoTc2-4510 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Ps[WlEPTB;Mz6wNVQyPyEQvF2= MkDXV2FPT0WU
NCI-H596 MmHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfSTY9rUUN3ME2zMlA1QTl5IN88US=> NXjZNphVW0GQR1XS
MPP-89 MlrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHLcFBnUUN3ME2zMlA2PjZ4IN88US=> NV7sWnV7W0GQR1XS
GCIY NUXtR2pFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmf1TWM2OD1|LkKwOFkyKM7:TR?= MXfTRW5ITVJ?
SW626 MojKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmS0TWM2OD1|LkK0OVQ{KM7:TR?= NFzCd3pUSU6JRWK=
OCI-AML2 NXfyVpd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NICwWpFKSzVyPUOuN|EzPzJizszN MlPwV2FPT0WU
NBsusSR M1rRO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzjTWM2OD1|LkO0PVM5KM7:TR?= M1[zOHNCVkeHUh?=
AN3-CA NXexT5pJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGf3bFdKSzVyPUOuOFQzOzhizszN NYTnTJppW0GQR1XS
EFM-19 Mn\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\4Rm5KSzVyPUOuOFg{OzlizszN NEfN[ZpUSU6JRWK=
RVH-421 MkPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\HNWlEPTB;Mz61Olg4PyEQvF2= NGTGUVVUSU6JRWK=
5637 MkO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NET2dXNKSzVyPUOuOlEyODNizszN M1H4WnNCVkeHUh?=
PANC-08-13 MnjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PEdGlEPTB;Mz62N|Q4OiEQvF2= M3nyVHNCVkeHUh?=
H9 MoDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDBR3JxUUN3ME2zMlY4OTR2IN88US=> NFzCd3dUSU6JRWK=
KARPAS-299 NF\Y[YhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTNwNkezOlEh|ryP MYTTRW5ITVJ?
TE-5 M1LOW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvhbZpKSzVyPUOuO|A4ODlizszN NYTPUGVtW0GQR1XS
NOS-1 M4mxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkf2TWM2OD1|Lke5PFM1KM7:TR?= MU\TRW5ITVJ?
HH NILoO|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHofoZvUUN3ME2zMlg{QDZ6IN88US=> NUfBVGF1W0GQR1XS
769-P NVXaZolxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEn0VItKSzVyPUOuPFk2OSEQvF2= MWHTRW5ITVJ?
CHP-212 M2LCOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTNwOUK1OFkh|ryP MX;TRW5ITVJ?
NCI-H82 NYn2PGZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHINGRtUUN3ME2zMlk2QTN4IN88US=> MUXTRW5ITVJ?
Mo-T NWL4SlRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MluwTWM2OD12LkC0N|EzKM7:TR?= NWDheJB{W0GQR1XS
BB65-RCC NILxT2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTRwMESzPVkh|ryP Mlm1V2FPT0WU
SW1990 NYT3RpByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\RWmlEPTB;ND6wOVkxQCEQvF2= NXzXSZhEW0GQR1XS
LK-2 NEfBW2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTRwMUGyPVMh|ryP MVfTRW5ITVJ?
ES5 Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjLcpN[UUN3ME20MlE{QTh3IN88US=> MlzGV2FPT0WU
JVM-3 MmLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTRwMUiyNlIh|ryP M2jCT3NCVkeHUh?=
RPMI-7951 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfPTWM2OD12LkKyOFE{KM7:TR?= M3O1e3NCVkeHUh?=
Calu-6 MoryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTrS|diUUN3ME20MlI4QDhzIN88US=> M{HqZXNCVkeHUh?=
LC-2-ad MkLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHK2VGVKSzVyPUSuNlk2PjhizszN MoflV2FPT0WU
SW954 M4H6XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LvS2lEPTB;ND6yPVY3KM7:TR?= M4HBT3NCVkeHUh?=
H-EMC-SS M4HVNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorUTWM2OD12LkOxPFMyKM7:TR?= NXPNNnhjW0GQR1XS
ES3 M1P6SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTRwM{W0OFEh|ryP NGPzW|RUSU6JRWK=
no-11 MlL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XoSGlEPTB;ND6zOVU2PCEQvF2= NEP5OmNUSU6JRWK=
LAN-6 M1Gzfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2KyOGlEPTB;ND60OVE5QSEQvF2= MWnTRW5ITVJ?
FTC-133 Ml;6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTRwNUO5OUDPxE1? NGjYTm5USU6JRWK=
8505C NFTJO|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTTb3B6UUN3ME20MlU1OjNizszN M{DvNXNCVkeHUh?=
SW620 NEi1T5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\5boJKSzVyPUSuOVcxPTdizszN M1WxNXNCVkeHUh?=
BCPAP MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELuPZdKSzVyPUSuOlM1QDFizszN NVrSPHJoW0GQR1XS
SK-LU-1 NILWPVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3pTWM2OD12Lk[2NFg6KM7:TR?= NG\1O4dUSU6JRWK=
NCI-H1623 MoPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTRwN{CyNlgh|ryP M1vCU3NCVkeHUh?=
C2BBe1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTRwN{SwNFgh|ryP NXPPc5JpW0GQR1XS
GP5d Mkf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TkeGlEPTB;ND63PFM5QCEQvF2= MX\TRW5ITVJ?
NB6 MlTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3joR2lEPTB;ND64OlIxPCEQvF2= NFXnc2NUSU6JRWK=
MDA-MB-157 NXf1UmJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zTZWlEPTB;ND64PFc3KM7:TR?= MXzTRW5ITVJ?
UMC-11 NGjOfZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\JWGlEPTB;ND64PFk3PCEQvF2= MknQV2FPT0WU
HCC1419 M4izRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTRwOUCwOlMh|ryP NU\Jb4xxW0GQR1XS
NCI-H2029 NVj2[YJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3ZfY9wUUN3ME20Mlk1OTh3IN88US=> MoXrV2FPT0WU
LXF-289 NVm1SmNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnITWM2OD13LkCzO|E6KM7:TR?= NX;ZOlFGW0GQR1XS
KINGS-1 MnXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTVwMEe3OFQh|ryP M3[4bXNCVkeHUh?=
HD-MY-Z M3PHd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1qxfGlEPTB;NT6yN|k3QSEQvF2= Mlf1V2FPT0WU
ESS-1 MkPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHNTWM2OD13LkK1OVk4KM7:TR?= NYT1fpZzW0GQR1XS
GI-1 MlrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfEWmY5UUN3ME21MlI4QTJ4IN88US=> M{\VWXNCVkeHUh?=
RPMI-2650 M2C1bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDTTWM2OD13LkO2NVYh|ryP NGjGdmpUSU6JRWK=
IA-LM NWexTowyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLISW5{UUN3ME21MlM6QDdzIN88US=> MULTRW5ITVJ?
KP-4 NIOyUlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkT1TWM2OD13LkS2N|M1KM7:TR?= NH7mV4NUSU6JRWK=
G-402 NFvBOYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHuSI5KSzVyPUWuOVE5PjVizszN M1e1XXNCVkeHUh?=
OS-RC-2 NGm1U3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PnUGlEPTB;NT61NlYxPCEQvF2= NUC2dIhxW0GQR1XS
NCI-H1155 MkHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPM[4lbUUN3ME21MlU1QTV3IN88US=> MV3TRW5ITVJ?
OE19 Mk[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HzbmlEPTB;NT62PFYzPCEQvF2= M2TOcHNCVkeHUh?=
U-2-OS NEft[FZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojPTWM2OD13Lki5NFE{KM7:TR?= M{f6PHNCVkeHUh?=
SCC-15 NYXI[mQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjDTVhKSzVyPUWuPVM3PjJizszN MWHTRW5ITVJ?
NCI-H630 MmToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlK5TWM2OD13Lkm5OFA1KM7:TR?= MXnTRW5ITVJ?
PFSK-1 NUjjU5Y{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\ZTWM2OD14LkC1NlU6KM7:TR?= MmPQV2FPT0WU
NCI-H1770 NIPa[GdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHETWM2OD14LkKwPFc1KM7:TR?= NVHvSJpMW0GQR1XS
SK-MEL-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPCcolKSzVyPU[uOFI6OTVizszN M2LLNXNCVkeHUh?=
LB1047-RCC MlOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPrZmNKSzVyPU[uOFc3OjVizszN NULjNZhVW0GQR1XS
NCI-H446 NHfTfVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2D0cWlEPTB;Nj62NlkzPSEQvF2= NXnNeWd[W0GQR1XS
SW780 NIfITVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWCwfG46UUN3ME22MlcxOTh3IN88US=> M4TEfnNCVkeHUh?=
NEC8 NWXSZlZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLDTWM2OD14Lke2OlMh|ryP MVvTRW5ITVJ?
NOMO-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTZwN{ixNVEh|ryP M{e5bHNCVkeHUh?=
COLO-668 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\yVmVKSzVyPU[uPFQ{QDdizszN NVfQ[GVuW0GQR1XS
MC116 NHPT[3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rDRmlEPTB;Nj65N|g6PyEQvF2= MlzLV2FPT0WU
HCC1937 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jwb2lEPTB;Nj65PVI2OSEQvF2= MkW1V2FPT0WU
NCI-N87 NXXvWZZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XMUGlEPTB;Nz6xPVI6OyEQvF2= Mo\QV2FPT0WU
COLO-320-HSR NHz3OZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3G3RmlEPTB;Nz6yNlc{QCEQvF2= MUXTRW5ITVJ?
HCC1806 M1njemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;1TWM2OD15LkK2NFQ1KM7:TR?= M1HsRXNCVkeHUh?=
OVCAR-3 NE\CTpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTdwM{OwN|gh|ryP M4fZ[XNCVkeHUh?=
NUGC-3 NGf3PIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfZZ5VrUUN3ME23MlM6Pjl2IN88US=> NFT6OFhUSU6JRWK=
SW1783 Mn7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TU[2lEPTB;Nz60N|E4PSEQvF2= MYfTRW5ITVJ?
GCT NHi5cGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;6cWlEPTB;Nz61OlkxPiEQvF2= M4rGVHNCVkeHUh?=
NCI-H2126 M3zWXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTdwN{O2NlUh|ryP M{HrcHNCVkeHUh?=
MEL-HO MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTXZoJKSzVyPUeuO|cxPTRizszN MkDNV2FPT0WU
CAPAN-1 M1PKbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTdwN{ezOVch|ryP M3fzRnNCVkeHUh?=
SW756 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjXRWFKSzVyPUeuO|g{OzNizszN MYPTRW5ITVJ?
SKG-IIIa NFTZdm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zRbmlEPTB;Nz64NVg6OiEQvF2= M4HONXNCVkeHUh?=
HCE-T NWTVRpprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTdwOEe3PFMh|ryP NYHFfXdIW0GQR1XS
Ca-Ski MmfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rIXGlEPTB;Nz65PVM5OyEQvF2= M4XxPHNCVkeHUh?=
COLO-684 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPUbmd7UUN3ME24MlAyQDF6IN88US=> MknGV2FPT0WU
KYSE-70 NXy0O44xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEn1bWRKSzVyPUiuNFc4OjlizszN M4qxNXNCVkeHUh?=
TI-73 MnfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;JWGlEPTB;OD6yOVg2OSEQvF2= NVjKd|ZMW0GQR1XS
BT-20 NXnLOHdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRThwMk[wOVIh|ryP M2SzfnNCVkeHUh?=
MHH-ES-1 M1OzNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\Ne3FUUUN3ME24MlUyQDN2IN88US=> NGDifXBUSU6JRWK=
TE-12 MnjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRThwNUm5N|Eh|ryP M4fNd3NCVkeHUh?=
YH-13 M1XKdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjvfnA5UUN3ME24MlYyODB6IN88US=> Mn;kV2FPT0WU
SF126 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvQd|lkUUN3ME24Mlg{QDZ3IN88US=> M2XyWXNCVkeHUh?=
J82 NHT3bWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRThwOUCwN|gh|ryP MXLTRW5ITVJ?
RCC10RGB Mnf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRThwOUm1OlEh|ryP M3mzZXNCVkeHUh?=
SK-UT-1 M{DPV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvHTWM2OD17LkC0PVQ2KM7:TR?= NWrrS2R[W0GQR1XS
LB2241-RCC NV7TW2k2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrZTWM2OD17LkG5NVM4KM7:TR?= NWDYUmhXW0GQR1XS
LB996-RCC MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljuTWM2OD17LkG5PFkh|ryP NGP5flZUSU6JRWK=
EPLC-272H MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3T5NWlEPTB;OT6zO|Y2PyEQvF2= NFzac|NUSU6JRWK=
CTV-1 M4DzS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17lNGlEPTB;OT61OlU{OiEQvF2= NWi2XYNVW0GQR1XS
HSC-2 M1PFemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnMT3RWUUN3ME25MlU4PTVizszN M1rFcXNCVkeHUh?=
SK-MEL-28 NIfFeFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTlwNkG4PVMh|ryP NXTEXXZiW0GQR1XS
MMAC-SF MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLNTWM2OD17Lk[4O|Uh|ryP M4rucXNCVkeHUh?=
CP50-MEL-B NXXwe2t{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXq2SnVqUUN3ME25Mlc2Pzh{IN88US=> NYL5SnJ[W0GQR1XS
HT-1080 NGmwZ4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLY[4RKSzVyPUmuO|c4OzlizszN MXfTRW5ITVJ?
HEC-1 NX\5[Y5TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7ocYhKSzVyPUGwMlM{PTJizszN MlHHV2FPT0WU
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D-566MG NIrCSo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrlVFJRUUN3ME20NU4zODh4IN88US=> M4H0T3NCVkeHUh?=
EGI-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWq4ToFsUUN3ME20Nk41OjhizszN MkPEV2FPT0WU
A204 NHr3OXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTDbph{UUN3ME20Nk43Ozh6IN88US=> MoPBV2FPT0WU
Saos-2 NVXafJZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPvU4xoUUN3ME20Nk45OzZ7IN88US=> NVfBd|BbW0GQR1XS
SNU-C2B MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTR|Lk[4O|gh|ryP NXLLT3lWW0GQR1XS
HLE M1voOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTR2LkC4OVYh|ryP MmDsV2FPT0WU
SW1463 NEG0cVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTR2Lkm5O|Eh|ryP NVv1UWlPW0GQR1XS
DSH1 MorhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTR3LkCwN|Mh|ryP MWTTRW5ITVJ?
MCF7 NYnJV5JFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DxTGlEPTB;NEWuOVA2OSEQvF2= MmjZV2FPT0WU
K5 NWnPRnpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnITWM2OD12NT65OFA2KM7:TR?= Mon1V2FPT0WU
NCI-H358 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGT3PYdKSzVyPUS3MlIyPSEQvF2= M1\LfnNCVkeHUh?=
NCI-H2030 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX5PIFKSzVyPUS3MlI{PzRizszN MUTTRW5ITVJ?
SW948 NVXKeVFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLocZBKSzVyPUS3MlQ3PCEQvF2= MV\TRW5ITVJ?
BALL-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\0SpJKSzVyPUS3MlYyPjhizszN MYjTRW5ITVJ?
TE-9 NUH3VoFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTR5Lkm1PFEh|ryP NE[yUZZUSU6JRWK=
SK-N-FI Ml3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHFR3VFUUN3ME20PE4xOzV6IN88US=> M2PWVHNCVkeHUh?=
KALS-1 NGPpRWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LPO2lEPTB;NEiuNVI5QSEQvF2= NYrZNYNPW0GQR1XS
HO-1-N-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLZV4J7UUN3ME20PE44PDR3IN88US=> NYKwS2psW0GQR1XS
NCI-H2452 Ml;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoewTWM2OD12OT6xNVUzKM7:TR?= NW\QboFSW0GQR1XS
OC-314 NEjOV2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVW2So9oUUN3ME20PU43QDN2IN88US=> NVqwXHpDW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
STAT3 / pSTAT3 / STAT6 / pSTAT6 / Mcl-1 / Cleaved Mcl-1 / Bcl-xl / Bim / puma / Bik / Bax / PARP / c-Myc; 

PubMed: 26811457     


(A) Western blot analysis of expressions of STAT3/p-STAT3 and STAT6/p-STAT6 as well as antiapoptotic members (Bcl-2, Bcl-xL, and Mcl-1) after 48 h of treatments in HDLM-2 cells. (B) Western blot analysis of expressions of proapoptotic proteins (Bim, Puma, Bik, Bax, and p-Bad) as well as caspase cascade molecules (PARP and c-Myc) after 48 h of treatments. β-Actin was used as an input control.

caspase3 / cleaved caspase 3; 

PubMed: 24481442     


(b) (i) N/TERT, (ii) SINCE and (iii) SINEG2 cells were either untreated (0 μM/DMSO) or treated with increasing doses of Navitoclax (ABT-263; 0.025–30 μM) and were incubated for 24 h. Next, cells were collected and whole-cell lysates were prepared and immunoblotted against anti-full-length Caspase 3 (∼35 kDa) antibody, whereas β-actin (∼42 kDa) was used as a protein-loading control. Apoptosis was assessed through detecting the cleaved bands of Caspase-3 (∼19, 17 kDa). 

26811457 24481442
Growth inhibition assay
Cell viability; 

PubMed: 25685063     


(C) Hcc827, (D) H292, and (E) H1993 cells were treated with increasing concentrations of albendazole or mebendazole in the presence of navitoclax (0, 1, 2, and 4 μM). Viability was determined after 1 day.

25685063
体内研究 用ABT-263处理H345移植瘤模型,按动物体重,每千克每天处理10mg ABT-263,结果肿瘤生长抑制率达80% ,肿瘤体积减小了50%以上,显示出ABT-263极强的抗癌效果。ABT-263作用于非小细胞肺癌和急性淋巴细胞白血病的移植瘤模型时,每天单独口服,结果显示肿瘤完全衰退。ABT-263单独作用于B-细胞淋巴瘤和多发性骨髓瘤的移植瘤模型时效果不明显,但是可以显著增强临床其他相关用药的药性。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

激酶实验:

用竞争性荧光偏振检测测定ABT-263 作用于Bcl-2 家族不同亚型的Ki值或者IC50值。使用如下的肽探针对或者蛋白对:f-bad (1 nM) 和Bcl-xL (6 nM), f-Bax (1 nM) 和Bcl-2 (10 nM), f-Bax (1 nM) 和Bcl-w (40 nM), f-Noxa (2 nM)和Mcl-1 (40 nM), 及f-Bax (1 nM) 和Bcl-2-A1 (15 nM)。用时间分辨荧光共振能转移法测定ABT-263和Bcl-xL作用的结合紧密度。1 nM 用His标记的Bcl-xL 与200 nM f-Bak,及 1 nM Tb标记的His抗体混合, 然后在室温下处理30分钟。
细胞实验:

[1]

- 合并
  • Cell lines: SCLC 细胞系
  • Concentrations: 0-1 μM
  • Incubation Time: 48小时
  • Method:

    人类肿瘤细胞系在37oC 含5% CO2环境下获得,SCLC 细胞系培养在RPMI 1640培养基中,培养基包含10% 胎牛血清, 1% 丙酮酸钠, 25 mM HEPES, 4.5 g/L葡萄糖, 1% 青霉素/链霉素。用含有10% FBS和1% 青霉素/链霉素的RPMI 1640培养基培养白血病和淋巴癌细胞系。细胞在96孔板上处理48小时,最终体积达到100ul。在体外测试ABT-263的细胞毒性。


    (Only for Reference)
动物实验:

[1]

- 合并
  • Animal Models: C.B.-17严重联合免疫缺陷-米黄鼠
  • Formulation: ABT-263在10% 乙醇, 30% 聚乙二醇400, 及60% Phosal 50 PG中制成
  • Dosages: 100 mg/kg/d
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (102.6 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+corn oil
7mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 974.61
化学式

C47H55ClF3N5O6S3

CAS号 923564-51-6
储存条件 粉状
溶于溶剂
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03181126 Recruiting Drug: Navitoclax|Drug: Chemotherapy|Drug: Venetoclax Acute Lymphoblastic Leukemia (ALL)|Lymphoblastic Lymphoma AbbVie November 27 2017 Phase 1
NCT02520778 Recruiting Drug: Navitoclax|Drug: Osimertinib Advanced Lung Non-Squamous Non-Small Cell Carcinoma|EGFR Exon 19 Deletion Mutation|EGFR NP_005219.2:p.L858R|EGFR NP_005219.2:p.T790M|Metastatic Lung Non-Squamous Non-Small Cell Carcinoma|Stage III Lung Non-Small Cell Cancer AJCC v7|Stage IIIA Lung Non-Small Cell Cancer AJCC v7|Stage IIIB Lung Non-Small Cell Cancer AJCC v7|Stage IV Lung Non-Small Cell Cancer AJCC v7 National Cancer Institute (NCI) March 31 2016 Phase 1
NCT02591095 Completed Drug: ABT-263 Platinum-resistant or Refractory Ovarian Cancer Centre Francois Baclesse|ARCAGY/ GINECO GROUP|French Cancer Research Hospital Program January 2016 Phase 2
NCT02079740 Recruiting Biological: Navitoclax|Drug: Trametinib Advanced Malignant Solid Neoplasm|Malignant Female Reproductive System Neoplasm|Metastatic Malignant Solid Neoplasm|Recurrent Lung Carcinoma|Recurrent Malignant Solid Neoplasm|Recurrent Pancreatic Carcinoma|Stage III Lung Cancer AJCC v7|Stage III Pancreatic Cancer AJCC v6 and v7|Stage IV Lung Cancer AJCC v7|Stage IV Pancreatic Cancer AJCC v6 and v7|Unresectable Malignant Solid Neoplasm National Cancer Institute (NCI) March 7 2014 Phase 1|Phase 2
NCT00887757 Completed Drug: ABT-263|Drug: gemcitabine Solid Tumors AbbVie|Genentech Inc. September 2009 Phase 1
NCT00888108 Completed Drug: ABT-263|Drug: Docetaxel Solid Tumor Abbott|Genentech Inc. July 2009 Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    I would like to deliver S1001 via i.p. injection, can you suggest a vehicle solution?

  • 回答:

    S1001 ABT-263 (Navitoclax) can be dissolved in 5% DMSO+corn oil at 7mg/ml as a clear solution.

  • 问题 2:

    Could you tell me if the catalog number S1001 can go through the hemato-encephalic barrier?

  • 回答:

    According to the paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223694/, ABT-263 can not cross brain-blood barrier.

Bcl-2 Signaling Pathway Map

Bcl-2 Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID