Imatinib (STI571)

For research use only. Not for use in humans.

目录号:S2475 别名: Gleevec, Glivec, CGP057148B 中文名称:伊马替尼

Imatinib (STI571) Chemical Structure

CAS No. 152459-95-5

Imatinib (STI571, CGP057148B, ST-1571)是一种多靶点酪氨酸激酶抑制剂,抑制v-Abl、c-Kit和PDGFR的IC50分别为0.6,0.1和0.1 μM。Imatinib (STI571) 可诱导自噬。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 746.33 现货
RMB 571.38 现货
RMB 980.11 现货
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客户使用Selleck生产的Imatinib (STI571)发表文献234篇:

产品安全说明书

PDGFR抑制剂选择性比较

生物活性

产品描述 Imatinib (STI571, CGP057148B, ST-1571)是一种多靶点酪氨酸激酶抑制剂,抑制v-Abl、c-Kit和PDGFR的IC50分别为0.6,0.1和0.1 μM。Imatinib (STI571) 可诱导自噬。
特性 Imatinib 是多靶点酪氨酸激酶抑制剂。
靶点
PDGFR [1]
(Cell-free assay)
c-Kit [2]
(M-07e cells)
v-Abl [1]
(Cell-free assay)
100 nM 100 nM 600 nM
体外研究

体外抑制一组酪氨酸和丝/苏氨酸蛋白激酶实验,说明Imatinib有效抑制v-Abl 酪氨酸激酶和PDGFR,IC50 分别为 0.6 和 0.1 μM。[1]Imatinib抑制 野生型 c-kit激酶活性的SLF依赖性激活,IC50约为0.1 μM, 与抑制PDGFR所需的浓度相似。[2] Imatinib 抑制人类支气管类癌细胞NCI-H727和胰腺类癌细胞 BON-1生长,IC50分别为 32.4 和 32.8 μM。[3] 最新研究显示Imatinib作用于慢性粒细胞白血病,通过下调hERG1 K(+)通道,具有恢复其抗白血病效果的潜力,而hERG1 K(+) 通道在白血病细胞中高表达,且易引发白血病。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LAMA-84 MoPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfa[YJKSzVyPUCuNFc{ODRizszN NF\IO5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
EM-2 MkXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXP[mhKSzVyPUCuNFg5QCEQvF2= M3foOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
MEG-01 NUjDXFZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HPbmlEPTB;MD6wPFkzOSEQvF2= M2PLRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
BV-173 NXLIV4tnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nQTGlEPTB;MD6xPFc1KM7:TR?= NXPacpBNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
K-562 NICxT3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nWVmlEPTB;MD6yNlQ{OiEQvF2= M1i1WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
CGTH-W-1 NFXhVHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PKWGlEPTB;MD6zPFM4PCEQvF2= MkDNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
ST486 MmLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHwd|hKSzVyPUCuOlg2PCEQvF2= NXfURpFLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
NCI-H1436 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwOUe4NFEh|ryP Ml;xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
NOS-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTFwNkWzPFMh|ryP NXy2fXNrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
A498 MofpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXDR|dKSzVyPUKuOVczOjNizszN NVX1eWM2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
BE-13 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTJwNkKxNFYh|ryP M{f3T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
SUP-T1 Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TIZmlEPTB;Mz64NlkxPyEQvF2= NHP0O3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
NCI-H1770 Mm[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nEfGlEPTB;NT61O|I3OiEQvF2= MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
IMR-5 M3P4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTZwMkKxOFch|ryP MofaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
LB2241-RCC MoPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfncWtXUUN3ME24MlA4Ozh2IN88US=> M33qfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
TGBC24TKB NEjwdXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTlfWNKSzVyPUiuN|QxPTJizszN NX7yU41bRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
SCC-15 NYTKboFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTFyLke3PFgh|ryP NYXkbI5ORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
BB49-HNC NXnsR4pCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjLZ3kyUUN3ME2xOE4{OzN3IN88US=> NUjjV5ZQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
ES7 M1nrTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHH6XVVKSzVyPUG0Mlc{PzlizszN MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
LB2518-MEL M3y4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\6dWlEPTB;MU[uOlA6PCEQvF2= MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
NCI-H510A MmHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\s[5RnUUN3ME2xO{4zPDR{IN88US=> NYq5cVIxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
TE-441-T NVPYUIV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHaTldKSzVyPUG3MlI5QDZizszN NVO1UYhrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
HH NFLsNpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTF5LkO5PVkh|ryP MoPoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
LC4-1 M4P4Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLnW|F4UUN3ME2xPE4xPjV{IN88US=> M4fENFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
KARPAS-45 M3PY[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DHPGlEPTB;MUiuNVg1QCEQvF2= NUXBT21RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
LB1047-RCC M1T4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\PVlc3UUN3ME2xPE41PDV{IN88US=> MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
NKM-1 NFq3RZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzKO|ZKSzVyPUG5MlM2PTJizszN NHHISVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
SCLC-21H NFfzO|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1j4SWlEPTB;MkCuNVI1PiEQvF2= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
RS4-11 NFzaeGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfwc2x6UUN3ME2yNE4{OzB6IN88US=> NXuwdHBURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
ALL-PO MoLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPwTWM2OD1{MD64NVQ6KM7:TR?= NGrKTZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
GDM-1 MkD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jtN2lEPTB;MkKuOVk1PSEQvF2= NHGydXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
DMS-79 NEjNOldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XjVmlEPTB;MkSuOFk{PCEQvF2= M2fMfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
MPP-89 M4[1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPRU5JKSzVyPUK1MlY5PzRizszN NUji[GxwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
NB10 M4KyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHvOZc4UUN3ME2yOk41Pjl7IN88US=> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
LS-513 NXrI[ZpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzKTFJKSzVyPUK2Mlg5PDdizszN NEDmZ209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
L-540 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfPTWM2OD1{Nj65NVQ{KM7:TR?= NUH4UHJNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
ES1 NIjxVm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3PU2RKSzVyPUK3MlUzOSEQvF2= NIjlPHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
NTERA-S-cl-D1 M1TZXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vGV2lEPTB;M{CuOVA6OyEQvF2= NHXHZYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
EW-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33zSWlEPTB;M{KuPVQ2PCEQvF2= NYPvfmp2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
Calu-6 M1XrWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTN|LkG4OVUh|ryP M37IdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
CTV-1 NU\aZos2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NID5XHBKSzVyPUOzMlk4QDlizszN NX3hSnpYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
YT M4ruOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPQSI5KSzVyPUO4MlUzODlizszN MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
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ECC4 MnfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPDW|BqUUN3ME25OE4zPTV3IN88US=> MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
NCCIT MlnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfVV5RKSzVyPUm1MlMzQTJizszN Ml\0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
MZ7-mel MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;GW2lEPTB;OUWuPVA1KM7:TR?= MmHkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
COLO-684 M1vVSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTl4LkKzPFUh|ryP MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
SU-DHL-1 M1H6[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTl4Lkm4OFIh|ryP NGPycm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
SF126 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjHV5BKSzVyPUm3MlUzOTdizszN NY\HXYJXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
NMC-G1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzNT2xKSzVyPUm4MlQ2PTRizszN NHrSNZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
NB14 NH[5N5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTl6LkmyNFgh|ryP NVKxTGo{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
VA-ES-BJ M3fWWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonTTWM2OD17OT60NFU3KM7:TR?= M165[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
CHO M3:5WWZ2dmO2aX;uJIF{e2G7 NUe3SHdSUW6qaXLpeIlwdiCxZjD3bYxlKHS7cHWgVIxifGWuZYSt[IVzcX[nZDDndo94fGhiZnHjeI9zKHKnY3XweI9zKGKndHGgdIhwe3Cqb4L5cIF1cW:wIHnuJGNJVyClZXzsd{whUUN3ME2wMlI1|ryPLh?= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjF4Nkm1NEc,OTJzNk[5OVA9N2F-
CHO M3\zbmZ2dmO2aX;uJIF{e2G7 NITDUpBKdmirYnn0bY9vKG:oIHPobY1memmlIGDES2YhemWlZYD0c5Ihf2m2aDDjMYtqfCCleYTvdIxie22rYzDkc41icW5icHjvd5Bpd3K7bHH0bY9vKGmwIFPIU{Bk\WyuczygTWM2OD1yLkK2{txONg>? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjF4Nkm1NEc,OTJzNk[5OVA9N2F-
CHO Mo\sSpVv[3Srb36gZZN{[Xl? Ml;ETY5pcWKrdHnvckBw\iClaHnt[ZJq[yCSRFfGJJJm[2WydH;yJJdqfGhiQ2PGMVFTKGO7dH;wcIF{dWmlIHTvcYFqdiCyaH;zdIhwenmuYYTpc44hcW5iQ1jPJINmdGy|LDDJR|UxRTBwOUdOwG0v MnLXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJzNk[5OVAoRjF{MU[2PVUxRC:jPh?=
K562 NYjFV2tnS3m2b4TvfIlkcXS7IHHzd4F6 MV;DfZRwfG:6aXOg[YZn\WO2IHnuJGs2PjJiY3XscJMtKEmFNUC9NE4yOc7:TT6= MmPjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ7NUGxNVMoRjF{OUWxNVE{RC:jPh?=
K562 MWXGeY5kfGmxbjDhd5NigQ>? MW\Jcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDndo94fGhidYPpcochVVSWIHHzd4F6NCCLQ{WwQVAvPM7:TT6= MlG4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR3NUK3OlAoRjF2NUWyO|YxRC:jPh?=
Sf9 MneySpVv[3Srb36gZZN{[Xl? NWnRNWQ4XFChVGLBUnNRV1KWRWK6JIlvcGmkaYTpc44hd2ZiQWTQZZNmKGGldHn2bZR6KGmwIFLDVnAu\XiycnXzd4lv\yCVZkmgZ4VtdHNuIFnDOVA:OC53zszNMi=> NVXwU5k1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWxOVU5PDFpPkG1NVU2QDRzPD;hQi=>
Sf9 Mlr5SpVv[3Srb36gZZN{[Xl? MmLzWHBgXFKDTmPQU3JVTVJ8IHXm[ox2gCCxZjDIc4VkcHO2M{OzOFIhcW5iQlPSVE1mgHC{ZYPzbY5oKFOoOTDj[YxteyxiSVO1NF0xNjoQvF2u NGrXdpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUG1OVg1OSd-MUWxOVU5PDF:L3G+
K562 NHfONIJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NHfSR25CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGs2PjJiY3XscJMtKEmFNUC9NE4yQDMQvF2u M1HoN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4M{OyOFQxLz5zNkOzNlQ1ODxxYU6=
U937 MXXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NV\jNlJ3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBWQTN5IHPlcIx{NCCLQ{WwQVE1|ryPLh?= M33wdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4M{OyOFQxLz5zNkOzNlQ1ODxxYU6=
BA/F3 Moi1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MlLhOFghcHK| NGPsfZdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KEKlcj3hZowhdmWpYYTpeoUh[2WubIOg[ZhxemW|c3nu[{BV\WxvUFTHSnJj\XSjIHvpcoF{\SCjc4Pld5Nm\CCjczDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE4xOjgQvF2u M4PiUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
BA/F3 MkXMRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NVzv[o05PSC2bzCxNEB2VQ>? MnLrOFghcHK| NGDYcXpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochXGWuLWPINk1MTCCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjdDC1JJRwKDFyIIXNJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MD6wOVXPxE1w Mn34QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2MUW4OlMoRjF4NEG1PFY{RC:jPh?=
BA/F3 MWnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MkjOOUB1dyBzMDD1US=> NXq4NpU2PDhiaILz MmfFRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCEQT;GN{Bk\WyuczDlfJBz\XO|aX7nJHRmdC2VSEOtV2gzNUuGIHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHH0JFUhfG9iMUCgeW0h[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlA5QM7:TT6= MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjRzNUi2N{c,OTZ2MUW4OlM9N2F-
32D MVHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MlzhOFghcHK| NEC5c2VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIEOySEBk\WyuczD0doFve2[nY4Tl[EB4cXSqIICyNVAh[2WubIOg[ZhxemW|c3nu[{BD[3JvYXLsJIF{e2W|c3XkJIF{KHC{b3zp[oVz[XSrb36gZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkGxNu69VS5? NGXTbnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkSxOVg3Oyd-MU[0NVU5PjN:L3G+
32D NYT5c|BSS3m2b4TvfIlkcXS7IHHzd4F6 M4HlemN6fG:2b4jpZ{Bi[3Srdnn0fUBi\2GrboP0JI1wfXOnIEOySEBk\WyuczD0doFve2[nY4Tl[EB4cXSqIICyNVAhSmO{LXHicEwhUUN3ME2wMlE6|ryPLh?= NHGzZWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkSxOVg3Oyd-MU[0NVU5PjN:L3G+
BA/F3 MnLkRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NHzGV241QCCqcoO= NF\XVWJCdnSrcILvcIln\XKjdHnvckBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LXHicEBie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNVnPxE1w M1jMOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
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BA/F3 NYTt[nVxSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M2HhO|Q5KGi{cx?= NXHxWXFUSW62aYDyc4xq\mW{YYTpc44h[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3hZowhSTN|NHygcZV1[W62IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC57NkNOwG0v MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjRzNUi2N{c,OTZ2MUW4OlM9N2F-
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BaF3 NGS3NnBCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M2rqTGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcZVzcW6nIFLhSlMh[2WubIOg[ZhxemW|c3nu[{B4cWymIIT5dIUhVlCPL1HMT{BjgSCdM1jdeIh6dWmmaX7lJJVxfGGtZTDhd5NigSxiSVO1NF04NjIQvF2u NG\Kem49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkm3NFQxOCd-MU[5O|A1ODB:L3G+
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... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-STAT3 / STAT3 / p-STAT5 / STAT5 ; 

PubMed: 18981115     


For phospho-STAT3 and Phospho-STAT5 detection, cells were then activated for 6 hrs with anti-CD3 and anti-CD28 Ab. Equivalent amounts of protein from cell lysates were separated by SDS-PAGE and western blot analysis was then performed using anti-phospho STAT3, anti-STAT3, anti-phospho STAT5 or anti-STAT5 Abs.

p-ZAP70 / ZAP70 / p-LAT / LAT ; 

PubMed: 18981115     


For the analysis of imatinib interference with early TCR signaling events, cells were activated for 5 min with anti-CD3 and anti-CD28 Abs and blots were probed with anti-phospho ZAP70, anti-ZAP70, anti-phospho LAT or anti-LAT antibodies. Untreated, non-activated cells were used as controls (NA).

p-STAT3 / STAT3 / p-STAT5 / STAT5 ; 

PubMed: 18981115     


For phospho-STAT3 and Phospho-STAT5 detection, cells were then activated for 6 hrs with anti-CD3 and anti-CD28 Ab. Equivalent amounts of protein from cell lysates were separated by SDS-PAGE and western blot analysis was then performed using anti-phospho STAT3, anti-STAT3, anti-phospho STAT5 or anti-STAT5 Abs.

p-ZAP70 / ZAP70 / p-LAT / LAT ; 

PubMed: 18981115     


For the analysis of imatinib interference with early TCR signaling events, cells were activated for 5 min with anti-CD3 and anti-CD28 Abs and blots were probed with anti-phospho ZAP70, anti-ZAP70, anti-phospho LAT or anti-LAT antibodies. Untreated, non-activated cells were used as controls (NA).

18981115
Immunofluorescence
RelB; 

PubMed: 20371728     


Nuclear proteins were extracted from the untreated and treated cells and nuclear levels of RelA and RelB were confirmed by immunocytochemistry 

Cortactin / F-actin ; 

PubMed: 20937825     


NIH3T3-SrcY527F cells were treated with DMSO or with 10 μm STI571 for 16 h, fixed and co-stained for cortactin (red, left panels) and F-actin (green, middle panels). Merged fields (right panels) demonstrate co-localization between cortactin and F-actin at invadopodia.

RelB; 

PubMed: 20371728     


Nuclear proteins were extracted from the untreated and treated cells and nuclear levels of RelA and RelB were confirmed by immunocytochemistry.

Cortactin / F-actin ; 

PubMed: 20937825     


NIH3T3-SrcY527F cells were treated with DMSO or with 10 μm STI571 for 16 h, fixed and co-stained for cortactin (red, left panels) and F-actin (green, middle panels). Merged fields (right panels) demonstrate co-localization between cortactin and F-actin at invadopodia.

20371728 20937825
Growth inhibition assay
Cell viability ; 

PubMed: 28435223