Lapatinib (GW-572016) Ditosylate

For research use only. Not for use in humans.

目录号：S1028 中文名称：二苯磺酸拉帕替尼

Lapatinib (GW-572016) Ditosylate Chemical Structure

CAS No. 388082-77-7

Lapatinib (GW-572016) Ditosylate是一种有效的EGFR 和 ErbB2抑制剂，在无细胞试验中IC50分别为10.8和9.2 nM。

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10mM (1mL in DMSO)	RMB 1564.18	现货
25mg	RMB 1214.79	现货
50mg	RMB 2104.83	现货
100mg	RMB 3286.41	现货
200mg	RMB 5487.3	现货
500mg	RMB 9746.1	现货
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客户使用Selleck生产的Lapatinib (GW-572016) Ditosylate发表文献117篇：

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产品安全说明书

HER2抑制剂选择性比较

生物活性

产品描述

Lapatinib (GW-572016) Ditosylate是一种有效的EGFR 和 ErbB2抑制剂，在无细胞试验中IC50分别为10.8和9.2 nM。

靶点

ErbB2 ^[1] (Cell-free assay)	EGFR ^[1] (Cell-free assay)	ErbB4 ^[1] (Cell-free assay)
9.2 nM	10.8 nM	367 nM

体外研究

Lapatinib 微弱抑制ErbB4活性，IC50为367 nM, 作用于EGFR和 ErbB2 比作用于其他激酶，如c-Src, c-Raf, MEK, ERK, c-Fms, CDK1, CDK2, p38, Tie-2,和 VEGFR-2选择性高300多倍。Lapatinib作用于HN5细胞时，显著抑制受体EGFR 和 ErbB2自磷酸化，这种作用存在剂量依赖性，IC50分别为170 nM和80 nM,而作用于BT474细胞时，IC50分别为210 nM 和 60 nM。与OSI-774和Iressa(ZD1839)优先抑制过量表达EGFR细胞生长不同, Lapatinib 抑制过量表达EGFR和ErbB2细胞生长。作用于过量表达EGFR或 ErbB2的细胞具有高抑制活性，IC50为0.09-0.21 μM,而作用于表达低水平EGFR或ErbB2的细胞，IC50为3-12 μM,比作用于正常纤维细胞选择性高100倍。Lapatinib有效抑制过量表达EGFR的HN5和A-431细胞生长，也抑制过量表达ErbB2的BT474和N87细胞生长，且显著诱导HN5细胞周期停在G1期，也诱导 BT474 细胞凋亡，与抑制AKT磷酸化相关。^[1] Lapatinib 作用于含EGFR的L858R和T790M突变的抗Gefitinib的H1975细胞显著抑制Stat3磷酸化，导致细胞生长受抑制，IC50为1-2 μM。^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
HN5 cell line	M2DP[3Bzd2yrZnXyZZRqd25iYYPzZZk>			Ml\vRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKTkWgZ4VtdCCuaX7lMEBKSzVyPUCuNFI2KM7:TR?=	NX7pPYx3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0PFM4PzJpPkG2OFg{Pzd{PD;hQi=>
BT474 cell line	MX;Qdo9tcW[ncnH0bY9vKGG\|c3H5			NYLYO2oySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCWFQ4PCClZXzsJIxqdmVuIFnDOVA:OC5yMkWg{txO	NXjB[3A2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0PFM4PzJpPkG2OFg{Pzd{PD;hQi=>
HN5 cell	NGPxU\|RIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MUXJcohq[mm2aX;uJI9nKEiQNTDj[YxtKGe{b4f0bEBi\nSncjC3NkBpenNuIFnDOVA:OC5zMjFOwG0>	MkXnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ5N{e0NVAoRjF4N{e3OFExRC:jPh?=
BT474 cell	M2G0VWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MVrJcohq[mm2aX;uJI9nKEKWNEe0JINmdGxiZ4Lve5RpKGGodHXyJFczKGi{czygTWM2OD1yLkC4JO69VQ>?	NH;PN\|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNke3O\|QyOCd-MU[3O\|c1OTB:L3G+
N87 cell	MlfyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MlTUTY5pcWKrdHnvckBw\iCQOEegZ4VtdCCpcn;3eIgh[W[2ZYKgO\|IhcHK\|LDDJR\|UxRTBwMEig{txO	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd5N{SxNEc,OTZ5N{e0NVA9N2F-
HFF cell	NYLNVIJsT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			MoXaTY5pcWKrdHnvckBw\iCKRl[gZ4VtdCCpcn;3eIgtKEmFNUC9PU46KM7:TR?=	MlvFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ5N{e0NVAoRjF4N{e3OFExRC:jPh?=
BT474	NIi1OmNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			MkHrRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCEVES3OEBk\WyuczDveoVz\XiycnXzd4lv\yCHclKyMEBKSzVyPUCuNFI2\|ryP	M4PRelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NkWzN\|M{Lz5zOE[1N\|M{OzxxYU6=
SKBR3	NIG5bpBEgXSxdH;4bYNqfHliYYPzZZk>		MVS3NkBpenN?	NFnycG9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0KUMzDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVAvODF5zszN	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB{OESyOUc,OTlyMki0NlU9N2F-
SKBR3	NXr5NY97S3m2b4TvfIlkcXS7IHHzd4F6		MoHMO\|IhcHK\|	MmnzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tDWjNiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JHNTSiCjc4PhfUwhUUN3ME2wMlAzQc7:TR?=	NWj3bWJmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4PFg4PjFpPkG5PFg5PzZzPD;hQi=>
A431	MXXDfZRwfG:6aXPpeJkh[XO\|YYm=		MoDXO\|IhcHK\|	NWTOTYNXS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTR\|MTDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVAvOTB2zszN	MkPGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6OEi3OlEoRjF7OEi4O\|YyRC:jPh?=
SK-BR-3	NWPFcnZkSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			M1jyXmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1utRnIuOyClZXzsd{Bi\nSncjDodpMh[nliQWTQJINwdnSnboSgZZN{[XluIFnDOVA:OC5yNN88US=>	NHKxSZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N\|c4QCd-MkCxOFM4Pzh:L3G+
SKHEP1	Ml;nRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			NU\BT25JSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTT2hGWDFiY3XscJMh[W[2ZYKgbJJ{KGK7IFHUVEBkd262ZX70JIF{e2G7LDDJR\|UxRTVwM988US=>	NULtTJpnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM4PzhpPkKwNVQ{Pzd6PD;hQi=>
MDA-MB-231	M17QPGFvfGmycn;sbYZmemG2aY\lJIF{e2G7			NFLwdoJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYX\0[ZIhcHK\|IHL5JGFVWCClb370[Y51KGG\|c3H5MEBKSzVyPUWuOO69VQ>?	NInGSnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N\|c4QCd-MkCxOFM4Pzh:L3G+
Hep3B2	NInaeohCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincEPCNkBk\WyuczDh[pRmeiCqcoOgZpkhSVSSIHPvcpRmdnRiYYPzZZktKEmFNUC9OU41Qc7:TR?=	M{HH[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUSzO\|c5Lz5{MEG0N\|c4QDxxYU6=
HepG2	MlrvRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			NHjGVHhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IHjyd{BjgSCDVGCgZ49vfGWwdDDhd5NigSxiSVO1NF03NjJ5zszN	NIOzd489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N\|c4QCd-MkCxOFM4Pzh:L3G+
MCF7	NHjyemlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhcHK\|IHL5JGFVWCClb370[Y51KGG\|c3H5MEBKSzVyPU[uOu69VQ>?	NHHWNFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N\|c4QCd-MkCxOFM4Pzh:L3G+
A431	M1PCNWZ2dmO2aX;uJIF{e2G7			MVHJcohq[mm2aX;uJI9nKEWJRmKgbY51emGlZXzseYxieiCyaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hSTR\|MTDj[YxteyCkeTDFUGlUSSxiSVO1NF0xNjB3Mt88US=>	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN2Nk[1OUc,OjB\|NE[2OVU9N2F-
N87	NWTkZYVOTnWwY4Tpc44h[XO\|YYm=			MoTrTY5pcWKrdHnvckBw\iCHcnLCNkBqdnS{YXPlcIx2dGG{IIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCQOEegZ4VtdHNiYomgSWxKW0FuIFnDOVA:OC5zzszN	NGCx[oU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO0OlY2PSd-MkCzOFY3PTV:L3G+
MIAPaCa	M3zpcmZ2dmO2aX;uJIF{e2G7			M3Lq[GlvcGmkaYTpc44hd2ZiRWLCZlIheGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJG1KSVCjQ3GgZ4VtdHNiYomgSWxKW0FuIFnDOVA:OC5zNN88US=>	Mlv4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1NlMoRjJyOEG3OVI{RC:jPh?=
MIAPaCa	NGfv[3FHfW6ldHnvckBie3OjeR?=			NFywS5BKdmirYnn0bY9vKG:oIFXHSnIheGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJG1KSVCjQ3GgZ4VtdHNiYomgSWxKW0FuIFnDOVA:OC52M{ROwG0>	NVr5UYRTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OjNpPkKwPFE4PTJ\|PD;hQi=>
SKBR3	M2TabGN6fG:2b4jpZ4l1gSCjc4PhfS=>			MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT2JTOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKGK7IILld4F7fXKrbjDkfYUhemWmdXP0bY9vKGG\|c3H5MEBKSzVyPUCuNFAz\|ryP	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[yPUc,OjFyOEC2Nlk9N2F-
SKOV3	MnjQR5l1d3SxeHnjbZR6KGG\|c3H5			M3;4V2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z\|IHPlcIx{KG:4ZYLlfJBz\XO\|aX7nJGhGWjJiYomgdoV{[Xq3cnnuJIR6\SC{ZXT1Z5Rqd25iYYPzZZktKEmFNUC9NE4xODQQvF2=	NXfXUpNkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3OjlpPkKxNFgxPjJ7PD;hQi=>
CAL27	NGLFTVJEgXSxdH;4bYNqfHliYYPzZZk>			MnqyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2FNOjdiY3XscJMhd3[ncnX4dJJme3OrbnegSWdHWiCkeTDy[ZNignW{aX6g[JlmKHKnZIXjeIlwdiCjc4PhfUwhUUN3ME2wMlAxP87:TR?=	NFnEUoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC4NFYzQSd-MkGwPFA3Ojl:L3G+
CAL27	NVnwPHBPTnWwY4Tpc44h[XO\|YYm=		MYmxOkBpenN?	NHzIbJpKdmirYnn0bY9vKG:oIFXHSk1qdmS3Y3XkJGVITlJicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKEODTEK3JINmdGy\|IH;2[ZJmgHC{ZYPzbY5oKEWJRmKgZYZ1\XJiMU[gbJJ{KGK7IGfld5Rmem5iYnzveEwhUUN3MEywMlA{Os7:TR?=	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[yPUc,OjFyOEC2Nlk9N2F-
A431	NYPNcnd1S3m2b4TvfIlkcXS7IHHzd4F6			M3n2UWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1OzFiY3XscJMhd3[ncnX4dJJme3OrbnegSWdHWiCkeTDy[ZNignW{aX6g[JlmKHKnZIXjeIlwdiCjc4PhfUwhUUN3ME2wMlk4\|ryP	Mn3UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyOEC2NlkoRjJzMEiwOlI6RC:jPh?=
HeLa	NHjFNZJEgXSxdH;4bYNqfHliYYPzZZk>			NHyxdVREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KG:4ZYLlfJBz\XO\|aX7nJGhFSUNiYomgdoV{[Xq3cnnuJIR6\SC{ZXT1Z5Rqd25iYYPzZZktKEmFNUC9OU46\|ryP	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[yPUc,OjFyOEC2Nlk9N2F-
A549	NWCzd5JpS3m2b4TvfIlkcXS7IHHzd4F6			NFO4RYlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KG:4ZYLlfJBz\XO\|aX7nJGhFSUNiYomgdoV{[Xq3cnnuJIR6\SC{ZXT1Z5Rqd25iYYPzZZktKEmFNUC9PE42\|ryP	NWDEdmZ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3OjlpPkKxNFgxPjJ7PD;hQi=>
SK-BR-3	NVfkcYV6SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			Mm\pRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDFdoJDOiCxdnXy[ZhxemW\|c3nu[{BpfW2jbjDTT{1DWi1\|IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD12LkO1{txO	NUPxe21NRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1O\|A5PDNpPkKxOVcxQDR\|PD;hQi=>
MDA-MB-468	NH3KU2lCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			M1rm[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgSWdHWiCxdnXy[ZhxemW\|c3nu[{BpfW2jbjDNSGEuVUJvNE[4JINmdGy\|IHL5JG1VXCCjc4PhfUwhUUN3ME2yN{41Ps7:TR?=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV5MEi0N{c,OjF3N{C4OFM9N2F-
HCT116	M3\YfmFvfGmycn;sbYZmemG2aY\lJIF{e2G7			MmjtRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKQ2SxNVYh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwQVQzNjN4zszN	NInMNow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUW3NFg1Oyd-MkG1O\|A5PDN:L3G+
BT474	MVjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MVi3NkBpenN?	NHfqNZJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLUOFc1KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDt[ZRpgWynbnWgZox2\SC\|dHHpcolv\y2kYYPl[EBu\XSqb3SsJGlEPTB;MD6wNlXPxE1?	NIXEV2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUi4O\|QxOyd-MkG4PFc1ODN:L3G+
NCI-N87	M1TYU2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		MU[zJIRigXN?	M4LoXmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMW45PyClZXzsd{Bi\nSncjCzJIRigXNiYomgcYV1cHmuZX7lJIJtfWVic4ThbY5qdmduIFnDOVA:OC5yOd88US=>	MmX1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzMEGxN\|IoRjJ{MUCxNVMzRC:jPh?=
BT474	NILyclVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NXTReJdQOyCmYYnz	MVvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKWNEe0JINmdGy\|IHHmeIVzKDNiZHH5d{BjgSCvZYTofYxmdmViYnz1[UB{fGGrbnnu[{whUUN3ME2wMlHPxE1?	NWe4doR[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxNFEyOzJpPkKyNVAyOTN{PD;hQi=>
NCI-N87	NIToNHdCdnSrdIXtc5Ih[XO\|YYm=	M4G1SVIxKG2pL3vn	NXvXNmZtOTRiZHH5dy=>	MoDSRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMW45PyClZXzsd{B5\W6xZ4Lh[pRm\CCrbjDheIh6dWmlIH3veZNmKGG\|c3Xzd4VlKGG\|IIT1cY9zKGe{b4f0bEBqdmirYnn0bY9vKGG2IEKwJI1oN2upLDDwc{BSTCCob4KgNVQh\GG7czDt[YF{fXKnZDDh[pRmeiBzOTDkZZl{	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjFyMUGzNkc,OjJzMEGxN\|I9N2F-
DIFI	M1\udWN6fG:2b4jpZ4l1gSCjc4PhfS=>		MUO0JIRigXN?	NV3mRld3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTEmISTDj[YxteyCjZoTldkA1KGSjeYOgZpkheHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{1j[XOnZDDmcJVwem:vZYTybYMh[W6jbInzbZMtKEmFNUC9NE4zOzYQvF2=	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
CAL27	NIHLcHJEgXSxdH;4bYNqfHliYYPzZZk>		Ml\kOEBl[Xm\|	M1n0PGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNCVDJ5IHPlcIx{KGGodHXyJFQh\GG7czDifUBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nMYJie2WmIH\seY9zd22ndILpZ{BidmGueYPpd{whUUN3ME2wMlU{\|ryP	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
GXF251L	MmrBR5l1d3SxeHnjbZR6KGG\|c3H5		M1;pR\|Qh\GG7cx?=	MmXiR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gS3hHOjVzTDDj[YxteyCjZoTldkA1KGSjeYOgZpkheHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{1j[XOnZDDmcJVwem:vZYTybYMh[W6jbInzbZMtKEmFNUC9NU41QM7:TR?=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
LXFA 629L	NVz0[\|NwS3m2b4TvfIlkcXS7IHHzd4F6		NWK2TlBjPCCmYYnz	MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMXGZCKDZ{OVygZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcocu[mG\|ZXSg[ox2d3KxbXX0dolkKGGwYXz5d4l{NCCLQ{WwQVIvQDgQvF2=	NXHZfGpORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
DU145	MnXaR5l1d3SxeHnjbZR6KGG\|c3H5		MoS3OEBl[Xm\|	NGjsN3ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFXTF2NTDj[YxteyCjZoTldkA1KGSjeYOgZpkheHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{1j[XOnZDDmcJVwem:vZYTybYMh[W6jbInzbZMtKEmFNUC9Nk46Qc7:TR?=	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
OVXF 899L	Ml:wR5l1d3SxeHnjbZR6KGG\|c3H5		MXi0JIRigXN?	MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDPWnhHKDh7OVygZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcocu[mG\|ZXSg[ox2d3KxbXX0dolkKGGwYXz5d4l{NCCLQ{WwQVMvOzYQvF2=	MnzJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNkm2NFEoRjJ{MU[5OlAyRC:jPh?=
LXFL 529L	MWTDfZRwfG:6aXPpeJkh[XO\|YYm=		NV7NNnpSPCCmYYnz	NV\t[o9HS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVFiITDC1NllNKGOnbHzzJIFnfGW{IESg[IF6eyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[udX;yc41mfHKrYzDhcoFtgXOrczygTWM2OD1\|LkWx{txO	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
LNCAP	NV\MTG9DS3m2b4TvfIlkcXS7IHHzd4F6		NXXKUYxkPCCmYYnz	NHHCNIpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNVkODUDDj[YxteyCjZoTldkA1KGSjeYOgZpkheHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{1j[XOnZDDmcJVwem:vZYTybYMh[W6jbInzbZMtKEmFNUC9N{43QM7:TR?=	NXXJVlhORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
LXFA 526L	NHLUfW1EgXSxdH;4bYNqfHliYYPzZZk>		Mnv6OEBl[Xm\|	NYHZUYd{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVFiIQTC1NlZNKGOnbHzzJIFnfGW{IESg[IF6eyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[udX;yc41mfHKrYzDhcoFtgXOrczygTWM2OD12LkKx{txO	NFjsW5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG2PVYxOSd-MkKxOlk3ODF:L3G+
UXF 1138L	Ml3qR5l1d3SxeHnjbZR6KGG\|c3H5		NXXRcXNGPCCmYYnz	MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVXGYhOTF\|OFygZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcocu[mG\|ZXSg[ox2d3KxbXX0dolkKGGwYXz5d4l{NCCLQ{WwQVQvPM7:TR?=	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
PC3M	NVLDcG5{S3m2b4TvfIlkcXS7IHHzd4F6		NVjaTXUxPCCmYYnz	MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR\|NOKGOnbHzzJIFnfGW{IESg[IF6eyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[udX;yc41mfHKrYzDhcoFtgXOrczygTWM2OD12LkW1{txO	MnTOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNkm2NFEoRjJ{MU[5OlAyRC:jPh?=
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SJ-GBM2	NXzoZWxQeUiWUzDhd5NigQ>?			MUDxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0pvR1LNNkBk\Wyucx?=	NXzGXWN5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
A673	NVfJNY9{eUiWUzDhd5NigQ>?			M17OTZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCDNkezJINmdGy\|	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
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BT-37	NIjXS4dyUFSVIHHzd4F6			MV7xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhSlRvM{egZ4VtdHN?	NHS1V3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
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U-2 OS	NUD6[HByeUiWUzDhd5NigQ>?			NXvLVYRSeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGWtNkBQWyClZXzsdy=>	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
Saos-2	NYO2dlNGeUiWUzDhd5NigQ>?			NUO4dIt3eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGPhc5MuOiClZXzsdy=>	M17YUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-SH	MWDxTHRUKGG\|c3H5			M1f3eJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSz3OMXNJKGOnbHzz	M{m2ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
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MG 63 (6-TG R)	MlHLdWhVWyCjc4PhfS=>			M1nFN5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCPRzC2N{ApPi2WRzDSLUBk\Wyucx?=	M2LrRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
A673	NVz0N5czeUiWUzDhd5NigQ>?			NHzob4pyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBCPjd\|IHPlcIx{MQ>?	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
BT-12	M1fqbpFJXFNiYYPzZZk>			NHLqb2RyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBDXC1zMjDj[Yxtew>?	NFThWHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
U-2 OS	MUnxTHRUKGG\|c3H5			M4fTfJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHUuOiCRUzDj[Yxtew>?	NYHodnRXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
Rh41	NWrieGt5eUiWUzDhd5NigQ>?			NXOzN3I{eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhWmh2MTDj[Yxtew>?	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
Rh18	NESzNVNyUFSVIHHzd4F6			NE\YNnFyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBTcDF6IHPlcIx{	NW\GfnhnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
Rh30	NVTKOHdseUiWUzDhd5NigQ>?			MmfhdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgVog{OCClZXzsdy=>	NFe1[Xc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
SK-N-SH	NGn1bnpyUFSVIHHzd4F6			MWDxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDTT{1PNVOKIHPlcIx{	M4[yTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
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HCT116	MVvBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NEjCcVc4OiCqcoO=	MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTFyLkGy{txO	NYXFN5VURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2PFQ4ODhpPkK5Olg1PzB6PD;hQi=>
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SKBR3	M2i4NmN6fG:2b4jpZ4l1gSCjc4PhfS=>		NH\YdnU4OiCqcoO=	MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT2JTOyClZXzsd{BwfmW{IHX4dJJme3OrbnegTGVTOiCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEmFNUC9NE4yP87:TR?=	NInHcFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUmwNlcyQSd-Mkm5NFI4OTl:L3G+
A431	MmfJR5l1d3SxeHnjbZR6KGG\|c3H5		MXS3NkBpenN?	M2XNSmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1OzFiY3XscJMhd3[ncjDlfJBz\XO\|aX7nJGVITlJiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCLQ{WwQVEvPjoQvF2=	NF6yNnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUmwNlcyQSd-Mkm5NFI4OTl:L3G+
NCI-H1975	MlvhR5l1d3SxeHnjbZR6KGG\|c3H5		M3SwWVczKGi{cx?=	NXLxTVVXS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVixPVc2KGOnbHzzJIhiemKxcnnu[{BGT0[UIGS3PVBOKG23dHHueEBie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO\|YYmsJGlEPTB;MUGuOFbPxE1?	NXHVOWxzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm5NFI4OTlpPkK5PVAzPzF7PD;hQi=>
MDA-MB-361	MnHuR5l1d3SxeHnjbZR6KGG\|c3H5		NI\kVVc4OiCqcoO=	M{LHU2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2zOlEh[2WubIOgc5ZmeiCneIDy[ZN{cW6pIFjFVlIh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSC\|dXzmc5Jpd2SjbXnu[UBDKGG\|c3H5MEBKSzVyPUGzMlc{\|ryP	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTlyMkexPUc,Ojl7MEK3NVk9N2F-
HepG2	NXHDTJFZTnWwY4Tpc44h[XO\|YYm=			NHfORpJKdmirYnn0bY9vKG:oIFXHSnIhcW5iaIXtZY4hUGWyR{KgZ4VtdHNuIFnDOVA:OC5yMkex{txO	NEXZemc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEC5OlU5OCd-M{CwPVY2QDB:L3G+
insect cells	NWTFUYNVTnWwY4Tpc44h[XO\|YYm=		NVvJRo9pPSCvaX7z	M2jTPGlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgbJVu[W5iRVfGVkBNQDV6UjDteZRidnRiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKGmwc3XjeEBk\WyuczDwdoVqdmO3YnH0[YQh\m:{IEWgcYlveyCob3zsc5dm\CCkeTDBWHAh[WSmaYTpc44h[W6mIH3lZZN2emWmIHHmeIVzKDNyIH3pcpMh[nliSGTSSkBie3OjeTygTWM2OD1yLkCzO\|U2\|ryP	M3nQU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm2OVgxLz5\|MEC5OlU5ODxxYU6=
Sf21	MmPKSpVv[3Srb36gZZN{[Xl?		MmXSOUBucW6\|	MorWTY5pcWKrdHnvckBw\iCQLYTldo1qdmGuIFfTWE11[WepZXSgdoVkd22kaX7hcpQhcHWvYX6gSWdHWiCWN{mwUUBufXSjboSg[ZhxemW\|c3XkJIlvKGKjY4Xsc5ZqenW\|IHnu[oVkfGWmIGPmNlEhcW6\|ZXP0JINmdGy\|IIDy[Ylv[3WkYYTl[EBnd3JiNTDtbY5{KG[xbHzve4VlKGK7IFHUVEBi\GSrdHnvckBidmRibXXhd5Vz\WRiYX\0[ZIhOzBibXnud{BjgSCKVGLGJIF{e2G7LDDJR\|UxRTBwMkK0PFnPxE1?	M4roUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm2OVgxLz5\|MEC5OlU5ODxxYU6=
MCF7	M{njPWN6fG:2b4jpZ4l1gSCjc4PhfS=>		M2nBUVI1KGi{cx?=	MnrrR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjCyOEBpenNiYomgV3JDKGG\|c3H5MEBKSzVyPUWuNFLPxE1?	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB7NkW4NEc,OzByOU[1PFA9N2F-
HCT116	M2LsO2N6fG:2b4jpZ4l1gSCjc4PhfS=>		M3vUbVI1KGi{cx?=	NXjLTYZpS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUG2JINmdGy\|IHHmeIVzKDJ2IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:PS57Mt88US=>	NFX5cnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEC5OlU5OCd-M{CwPVY2QDB:L3G+
HepG2	M1H4TWN6fG:2b4jpZ4l1gSCjc4PhfS=>		NVLxNJZjOjRiaILz	MoCyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgNlQhcHK\|IHL5JHNTSiCjc4PhfUwhUUN3ME2xNU44Oc7:TR?=	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB7NkW4NEc,OzByOU[1PFA9N2F-
Caco	MnXzR5l1d3SxeHnjbZR6KGG\|c3H5		NEH1cZMzPCCqcoO=	M4nwPWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNi[29iY3XscJMh[W[2ZYKgNlQhcHK\|IHL5JHNTSiCjc4PhfUwhUUN3ME2xNk4yOc7:TR?=	M2LwSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm2OVgxLz5\|MEC5OlU5ODxxYU6=
HepG2	MWfDfZRwfG:6aXPpeJkh[XO\|YYm=			NXW3eFhIS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNuIGTDOVA:Pi5\|zszN	NXKz[plDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzOFQ6ODZpPkOwN\|Q1QTB4PD;hQi=>
L929	MkD0R5l1d3SxeHnjbZR6KGG\|c3H5		MUK3NkBpenN?	NFXRe\|JEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBNQTJ7IHPlcIx{KGG\|c3Xzd4VlKGG\|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME2yMlA2\|ryP	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODVyOEO3PUc,OzB3MEizO\|k9N2F-
A431	NUnXfpZpSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NIfDXmQ4OiCqcoO=	MlG1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCDNEOxJINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Oi54Nt88US=>	MlzRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB3MEizO\|koRjNyNUC4N\|c6RC:jPh?=
A549	MoDzRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M4j2NlczKGi{cx?=	MmXoRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCDNUS5JINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Oy54NN88US=>	MnvzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB3MEizO\|koRjNyNUC4N\|c6RC:jPh?=
A549	MX;DfZRwfG:6aXPpeJkh[XO\|YYm=	NFrxfno3KHWP	MXmyOEBpenN?	NF;2WllEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG\|c3Xzd4VlKGG\|IHXm[oVkfCCxbjDpcpRz[WOnbHz1cIFzKEGWUDDs[ZZmdHNiYYSgOkB2VSCjZoTldkAzPCCqcoOgZpkhdHWlaX\ldoF{\S2udXPp[oVzcW5iYnHz[YQh[XO\|YYm=	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODVyOEO3PUc,OzB3MEizO\|k9N2F-
HN5	MXLGeY5kfGmxbjDhd5NigQ>?		M1\NS\|I1KGi{cx?=	NF;qN3JKdmirYnn0bY9vKG:oIFXHSk1qdmS3Y3XkJGVITlJicHjvd5Bpd3K7bHH0bY9vKGG2IGT5dk1z\XOrZIXlJIlvKGi3bXHuJGhPPSClZXzsd{BxemWrbnP1ZoF1\WRiZn;yJFI1KGi{czDmc4xtd3enZDDifUBGT0Zvc4TpcZVt[XSrb36gZY5lKG2nYYP1doVlKGGodHXyJFE2KG2rboOgZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|LDDJR\|UxRTBwMEJOwG0>	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODZyMEG0PUc,OzB4MECxOFk9N2F-
MCF7	NIDPb25CdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M2nOc\|czKGi{cx?=	MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF01NjZ7Md88US=>	MoLOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB5OUKxNFEoRjNyN{myNVAyRC:jPh?=
MDA231	NWXBdFV4SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		Mkn0O\|IhcHK\|	NWC4fWxySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEzOzFiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME20MlY6Oc7:TR?=	NHPrVXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEe5NlExOSd-M{C3PVIyODF:L3G+
SK-MEL-19	MlPuRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NELLeWs4OiCqcoO=	MnrFRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCVSz3NSWwuOTliY3XscJMhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCudX3pcoV{[2WwY3WgZZN{[XluIFfJOVA:Pc7:TR?=	NXjkd3dLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C4NFI4OzBpPkOwPFAzPzNyPD;hQi=>
JeKo1	MVnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		Mn\6O\|IhcHK\|	MlO2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCMZVvvNUBk\WyuczDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJIx2dWmwZYPj[Y5k\SCjc4PhfUwhT0l3ME21{txO	MoXZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB6MEK3N\|AoRjNyOECyO\|MxRC:jPh?=
MIAPaCa2	NID6dZRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M1HFU\|czKGi{cx?=	NF\tUnpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3JRXBiS2F{IHPlcIx{KGmwY4XiZZRm\CCob4KgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ibIXtbY5me2OnbnPlJIF{e2G7LDDHTVUxRTFyzszN	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODhyMkezNEc,OzB6MEK3N\|A9N2F-
U87MG	MVrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NXz5W3ZKPzJiaILz	NETr[\|dCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGW4O21IKGOnbHzzJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hdHWvaX7ld4NmdmOnIHHzd4F6NCCJSUWwQVEx\|ryP	MnvLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB6MEK3N\|AoRjNyOECyO\|MxRC:jPh?=
MV4-11	NHjjdJNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NIXVT4c4OiCqcoO=	MVPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2YND2xNUBk\WyuczDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJIx2dWmwZYPj[Y5k\SCjc4PhfUwhT0l3ME2xNO69VQ>?	MmPaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB6MEK3N\|AoRjNyOECyO\|MxRC:jPh?=
DU145	MXHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M124SVczKGi{cx?=	MmGwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCGVUG0OUBk\WyuczDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJIx2dWmwZYPj[Y5k\SCjc4PhfUwhT0l3ME2yNO69VQ>?	M4jUUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOECyO\|MxLz5\|MEiwNlc{ODxxYU6=
HCT116	NI\rPJNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NH7uNlQ4OiCqcoO=	NWXLTpBtSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCudX3pcoV{[2WwY3WgZZN{[XluIFfJOVA:OjEQvF2=	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODhyMkezNEc,OzB6MEK3N\|A9N2F-
MDA-MB-231	M1q5TGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NYfSPFlKPzJiaILz	MlXNRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGmwY4XiZZRm\CCob4KgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ibIXtbY5me2OnbnPlJIF{e2G7LDDHTVUxRTJyzszN	M2XoNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOECyO\|MxLz5\|MEiwNlc{ODxxYU6=
T47D	MlzqRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M2qwVVczKGi{cx?=	M3;2TmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iVES3SEBk\WyuczDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJIx2dWmwZYPj[Y5k\SCjc4PhfUwhT0l3ME20NO69VQ>?	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODhyMkezNEc,OzB6MEK3N\|A9N2F-
A431	NH7GTndHfW6ldHnvckBie3OjeR?=		M2rWN\|kxKG2rboO=	M1uxNGlvcGmkaYTpc44hd2ZiRVfGVkBqdiCqdX3hckBCPDNzIHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBGT0Zvc4TpcZVt[XSnZDDFS2ZTKGG3dH;wbI9{eGixconsZZRqd25icILlbY5kfWGkdHXkJIZweiB7MDDtbY5{KG[xbHzve4VlKGK7IFXHSk1{fGmvdXzheIlwdiCkeTDzZY5lf2mlaD3FUGlUSSxiSVO1NF0xNjB{Md88US=>	NXHibWhORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C5O\|M4OzVpPkOwPVc{PzN3PD;hQi=>
UCH1	MkHFRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MVS3NkBpenN?	Mof2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCXQ1ixJINmdGy\|IH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCjbHHtZZIh[my3ZTDhd5NigSxiSVO1NF0{NjMQvF2=	NGG0RY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEm3N\|c{PSd-M{C5O\|M4OzV:L3G+
WS1	Mo\PR5l1d3SxeHnjbZR6KGG\|c3H5		MmjnO\|IhcHK\|	MojqR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gW3MyKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJiYnz1[UBie3OjeTygTWM2OD1zM988US=>	MnLVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB7N{O3N\|UoRjNyOUezO\|M2RC:jPh?=
UMCHOR1	M2fqdGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MmrhO\|IhcHK\|	MlLWRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCXTVPIU3IyKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJiYnz1[UBie3OjeTygTWM2OD1{Nd88US=>	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODl5M{ezOUc,OzB7N{O3N\|U9N2F-
CH22	NVryNHl[SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MoDHO\|IhcHK\|	NU\adIxySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDTFIzKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJiYnz1[UBie3OjeTygTWM2OD1{Nd88US=>	M3rzV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOUezO\|M2Lz5\|MEm3N\|c{PTxxYU6=
UCH7	NF7DPXpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M3fTWFczKGi{cx?=	M3f4Z2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iVVPIO{Bk\WyuczDt[YF{fXKnZDDh[pRmeiB5MjDodpMh[nliYXzhcYFzKGKudXWgZZN{[XluIFnDOVA:OjcQvF2=	NVu4UJl1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C5O\|M4OzVpPkOwPVc{PzN3PD;hQi=>
UCH12	NUXNRlBMSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NXzvWHMyPzJiaILz	NULo[3dVSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVR2gyOiClZXzsd{Bu\WG\|dYLl[EBi\nSncjC3NkBpenNiYomgZYxidWG{IHLseYUh[XO\|YYmsJGlEPTB;M{ROwG0>	M3LOOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOUezO\|M2Lz5\|MEm3N\|c{PTxxYU6=
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HCC1954	MVfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NIjuZXY4OiCqcoO=	MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFQ{G5OVQh[2WubIOgc5ZmemW6cILld5NqdmdiSFXSNkBie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVXPxE1?	M3[yT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK1PFk1Lz5\|MUGyOVg6PDxxYU6=
NCI-H1975	MkTPRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NIjmWFE4OiCqcoO=	MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3INVk4PSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVnPxE1?	M{PDUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK1PFk1Lz5\|MUGyOVg6PDxxYU6=
A549	Ml3ERY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MoHNO\|IhcHK\|	MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUGx{txO	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{NUi5OEc,OzFzMkW4PVQ9N2F-
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SW480	NWToOVFwSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NGjybWI4OiCqcoO=	NFzzVoZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXOFgxKGOnbHzzJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zMj61PO69VQ>?	MkfIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF{MEK5PVAoRjNzMkCyPVkxRC:jPh?=
NCI-H1975	Mn3SRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MoeyO\|IhcHK\|	MXjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3INVk4PSClZXzsd{BqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;MUKuOljPxE1?	MoOyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF{MEK5PVAoRjNzMkCyPVkxRC:jPh?=
A549	NX;OUJVNSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NV;KZ\|FPPzJiaILz	NH3Z[GpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTF2LkpOwG0>	NXXHO5dtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyNFI6QTBpPkOxNlAzQTlyPD;hQi=>
A549	Mn7tSpVv[3Srb36gZZN{[Xl?	MljyNVUhfU1?	NXL0UIdNPDhiaILz	Mn[0TY5pcWKrdHnvckBw\iClZXzsJI1q\3KjdHnvckBqdiCFTT3kbYwudGGkZXzs[YQhcHWvYX6gRVU1QSClZXzsd{B5\W6xZ4Lh[pRm\CCrbjC0PEBpenNicH;zeE1n\XK2aXzpfoF1cW:wIIrlZpJi\mm\|aDDlcYJzgW:\|IHH0JFE2KHWPIHnuZ5Vj[XSnZDDmc5IhPDhiaILzJIJ6KGOxbn\vZ4FtKG2rY4Lvd4NweGmlIH3leIhw\A>?	NFz4e4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUKwNlk6OCd-M{GyNFI6QTB:L3G+
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SUM159	MkfyRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NYPaclVCPzJiaILz	MonKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCVVV2xOVkh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9PU44Ps7:TR?=	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTV2NkG5O{c,OzF3NE[xPVc9N2F-
KG1a	MU\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M2e2PFczKGi{cx?=	M2[0bmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS1exZUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME25Mlc3\|ryP	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTV2NkG5O{c,OzF3NE[xPVc9N2F-
MCF7	M134TWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M{[4SVczKGi{cx?=	MU\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF03NjkQvF2=	NWTuVZBrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G2OVU1OjlpPkOxOlU2PDJ7PD;hQi=>
A2780	MUTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MVK3NkBpenN?	NWn5WXVCSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCCpcn;3eIghcW6ldXLheIVlKG[xcjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUGwMlTPxE1?	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTZ3NUSyPUc,OzF4NUW0Nlk9N2F-
HT-29	Mne5RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NUnDcoJCPzJiaILz	MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiWLUK5JINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OTJwNkhOwG0>	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTZ3NUSyPUc,OzF4NUW0Nlk9N2F-
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NMC-G1 cell	NHXwbnNIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NHf3bYRKdmirYnn0bY9vKG:oIHj1cYFvKE6PQz3HNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvPTR3MEGg{txO	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
NTERA-S-cl-D1 cell	MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NY\XOoM3UW6qaXLpeIlwdiCxZjDoeY1idiCQVFXSRU1UNWOuLVSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok4zPjV4MTFOwG0>	NXzCSndRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
OCUB-M cell	NHfkUoVIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MYrJcohq[mm2aX;uJI9nKGi3bXHuJG9EXUJvTTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUCuNFU4PCEQvF2=	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
OS-RC-2 cell	NIDZOVhIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MYLJcohq[mm2aX;uJI9nKGi3bXHuJG9UNVKFLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlk6OTl7IN88US=>	NUPBZ\|ZSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
OVCAR-4 cell	Mmi5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M3zoVWlvcGmkaYTpc44hd2ZiaIXtZY4hV1[FQWKtOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVkvOTF4N{Wg{txO	MnLPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
RL95-2 cell	MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NIT4XZFKdmirYnn0bY9vKG:oIHj1cYFvKFKOOUWtNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvOTV4NzFOwG0>	M2juVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
SW954 cell	M4jxc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7			M2n3fGlvcGmkaYTpc44hd2ZiaIXtZY4hW1d7NUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlM6OjR3IN88US=>	NH7BfVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
SW962 cell	MnnpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MkHUTY5pcWKrdHnvckBw\iCqdX3hckBUXzl4MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUWuN\|kzPDVizszN	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
TE-1 cell	NHXyd4lIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NEPPWIpKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlAzOTV7IN88US=>	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
A253 cell	NIDHdItIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MYHJcohq[mm2aX;uJI9nKGi3bXHuJGEzPTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkC0PFMh\|ryP	M3jZdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
A388 cell	M3[5dmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NY\MUIxoUW6qaXLpeIlwdiCxZjDoeY1idiCDM{i4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4xPDh\|IN88US=>	MkiyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
BB30-HNC cell	MmP0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NG\F[VBKdmirYnn0bY9vKG:oIHj1cYFvKEKEM{CtTG5EKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57N{OzOUDPxE1?	NUTqN4E1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
TE-12 cell	MmfsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NF\HSllKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44OjJ3ODFOwG0>	NE\Icmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
TE-5 cell	M2HT[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NWGyV5VKUW6qaXLpeIlwdiCxZjDoeY1idiCWRT21JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4zPDZ3NDFOwG0>	NWTvZ2RoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
TE-6 cell	NIXpPVNIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MVPJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkS5NFU4KM7:TR?=	M{fHNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
TE-8 cell	M1W1PWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MknKTY5pcWKrdHnvckBw\iCqdX3hckBVTS16IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;ND6wN\|c{KM7:TR?=	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
TE-9 cell	M{HVSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MXzJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkW1NlAyKM7:TR?=	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
TK10 cell	NFXTNYRIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M4\PTGlvcGmkaYTpc44hd2ZiaIXtZY4hXEtzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUSuNVY2OjJizszN	NVzRTYdHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
DSH1 cell	NXK2RmRoT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			MXXJcohq[mm2aX;uJI9nKGi3bXHuJGRUUDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkC5N\|k3KM7:TR?=	MnjoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
ECC12 cell	NEnkdopIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M4T6R2lvcGmkaYTpc44hd2ZiaIXtZY4hTUOFMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlA6OjNzIN88US=>	MnrHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
EKVX cell	M3n0OGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			M1fO[mlvcGmkaYTpc44hd2ZiaIXtZY4hTUuYWDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUCuOFQ5PzRizszN	M4m3c\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
HCC2218 cell	M16zbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NYqyW2hIUW6qaXLpeIlwdiCxZjDoeY1idiCKQ1OyNlE5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yNUOyOkDPxE1?	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
LB2241-RCC cell	NIDaeXBIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MlvhTY5pcWKrdHnvckBw\iCqdX3hckBNSjJ{NEGtVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5zNUSwN{DPxE1?	M1XwclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
LB996-RCC cell	MmXsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NGXpVVdKdmirYnn0bY9vKG:oIHj1cYFvKEyEOUm2MXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTFwM{[yNlgh\|ryP	MmD6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
LC-1F cell	NHP3ZllIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NH;EbIRKdmirYnn0bY9vKG:oIHj1cYFvKEyFLUHGJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{QDJ2NDFOwG0>	NHLEbGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
LS-513 cell	MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NIm3[nFKdmirYnn0bY9vKG:oIHj1cYFvKEyVLUWxN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvPDByNEGg{txO	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-ErbB2 / t-ErbB2 / p-Akt / t-Akt / p-Erk / t-Erk; PubMed: 25238247 PLoS One Dose response of lapatinib and PD168393 on phosphorylation of ErbB2, AKT and ERK in Calu3 and SkBr3 cells in response to EGF treatment. p-ErbB2: phosphorylated ErbB2; t-ErbB2: total-ErbB2; p-AKT: phosphorylated AKT; t-AKT: total AKT; p-ERK: phosphorylated ERK; t-ERK: total ERK. pEGFR / EGFR / p-mTOR / mTOR / PARP / c-PARP ; PubMed: 28938602 Oncotarget SKBR3 and 78617 cells were treated with lapatinib as in panel A, then the expression of phospho-ErbB2 (Tyr1221/1222), ErbB2, phospho-EGFR (Tyr1068), EGFR, phospho-Akt (Ser473), Akt, phospho-Erk1/2 (Thr202/Tyr204), Erk2, phospho-mTOR (Ser2448), and mTOR were analyzed using Western blotting. All values are presented as the mean ± standard error (S.E.) (**p < 0.01).	25238247 28938602
Growth inhibition assay	Cell viability ; PubMed: 24947784 Oncotarget Huh7 (A), HepG2 (B), or HA22T (C) HCC cells were left untreated or treated with 0.1% DMSO (vehicle, D) or with DMSO containing various concentrations of lapatinib (1.25, 2.5, 5, or 10 μM) for 3 days. Relative amounts of viable cells were detected by MTS assay. O.D. values from DMSO-treated control cells were designated 100%.	24947784

体内研究

Lapatinib 按~100 mg/kg剂量口服处理，每天两次，显著抑制BT474和HN5移植瘤生长，这种作用存在剂量依赖性。^[1] 与在体外活性一致，Lapatinib按100-150 mg/kg剂量处理携带H1975肿瘤的小鼠，延迟肿瘤生长。^[3]

激酶实验：^[1]	- 合并体外激酶实验: 通过测量抑制肽底物磷酸化的情况而获得抑制酶活性的IC50值。通过杆状病毒表达系统纯化EGFR 和 ErbB2的细胞外激酶域。在96孔圆底板上进行EGFR和ErbB2反应，终体积为45 μL。反应混合物含50 mM 4-吗啉丙磺酸(pH 7.5), 2 mM MnCl₂, 10 μM ATP, 1 μCi [γ³³P] ATP/每次反应, 50 μM 肽 A [生物素-(氨基)-EEEEYFELVAKKK-CONH2], 1 mM 二流苏糖醇，及 1 μL DMSO（含连续稀释的Lapatinib，起始浓度为10 μM）。加入指定纯化的 1型受体胞内域，开始反应。加入的酶量为为1 pmol/每组反应(20 nM)在23^oC下反应10分钟，加入45 μL 0.5%溶于水的磷酸，终止反应。终止反应混合物(75 μL) 转移到磷酸纤维过滤板上。板过滤，然后使用200 μL 0.5% 磷酸冲洗3次。每孔加入闪烁剂(50 μL) , 在Packard Topcount上测量每组反应。通过10点剂量反应曲线获得IC50值。
细胞实验：^[1]	- 合并 Cell lines: HFF, MCF-7, T47D, A-431, HN5, BT474, N87, CaLu-3, HB4a, 和 HB4a c5.2 Concentrations: 溶于 DMSO,终浓度为~100 μM Incubation Time: 72小时 Method: 使用不同浓度Lapatinib处理细胞72小时。使用亚甲基蓝染色测定相对细胞数。使用Spectra酶标仪在620 nm 处测定吸光值。通过碘化丙啶染色和渗透BrdUrd的抗体检测，测量细胞死亡和细胞周期分析。 (Only for Reference)
动物实验：^[1]	- 合并 Animal Models: 皮下移植HN5细胞的CD-1雌性裸鼠,皮下移植BT474细胞的 C.B-17 SCID 雌性小鼠 Dosages: ~100 mg/kg Administration: 口服处理，每天两次 (Only for Reference)

参考文献

[1] Rusnak DW, et al. Mol Cancer Ther, 2001, 1(2), 85-94.

溶解度 (25°C)

体外	DMSO	100 mg/mL (108.05 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 2% DMSO+40% PEG 300+5% Tween 80+53% ddH2O	1.25 mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Lapatinib (GW-572016) Ditosylate SDF

分子量	925.46
化学式	C₂₉H₂₆ClFN₄O₄S.2C₇H₈O₃S
CAS号	388082-77-7
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2022-01-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04608409	Recruiting	Drug: Lapatinib and Paclitaxel	Ovarian Cancer	Frederick R. Ueland M.D.\|University of Kentucky	November 16 2020	Phase 1
NCT03075995	Unknown status	Other: hight-fat breakfast	Breast Cancer	Sun Yat-sen University	April 12 2017	Not Applicable
NCT02338245	Completed	Drug: ASLAN001\|Drug: Lapatinib\|Drug: Capecitabine	Metastatic Breast Cancer	Aslan Pharmaceuticals	December 29 2014	Phase 2
NCT02294786	Terminated	Drug: Lapatinib\|Drug: Capecitabine\|Drug: Octreotide	Cancer	Novartis Pharmaceuticals\|Novartis	December 17 2014	Phase 2
NCT02158507	Active not recruiting	Drug: Combination of Veliparib + Lapatinib	Metastatic Triple Negative Breast Cancer	University of Alabama at Birmingham\|Scariot Foundation\|GlaxoSmithKline\|AbbVie	September 2014	Not Applicable
NCT01782651	Completed	Drug: Lapatinib plus capecitabine	Neoplasms Breast	GlaxoSmithKline	August 2014	--

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
If I need to use S1028 for treating tumor-bearing mice with injection, how could I prepare the solution?
回答：
S1028 Lapatinib Ditosylate can be dissolved in 2% DMSO/30% PEG 300/ddH2O at 10 mg/ml as clear solution.

HER2 Signaling Pathway Map

HER2 Inhibitors with Unique Features

选择性强的EGFR抑制剂

Erlotinib HCl (OSI-744) : EGFR-selective, IC50=2 nM.
活性最高的EGFR抑制剂

Afatinib (BIBW2992) : EGFR(wt), IC50=0.5 nM; EGFR(L858R), IC50=0.4 nM; EGFR(L858R/T790M), IC50=10 nM; HER2, IC50=14 nM.
FDA批准的EGFR抑制剂

Lapatinib : Approved by FDA for breast cancer.
最新的EGFR抑制剂

CO-1686 (AVL-301) ^New : Irreversible, mutant-selective EGFR inhibitor with K_i of 21.5 nM and 303.3 nM for EGFRL858R/T790M and EGFRWT, respectively.

研究领域

产品类型

定制您的化合物库

Lapatinib (GW-572016) Ditosylate

客户使用Selleck生产的Lapatinib (GW-572016) Ditosylate发表文献117篇：

产品安全说明书

HER2抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Lapatinib (GW-572016) Ditosylate SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2022-01-17)

技术支持

常见问题及建议解决方法

HER2 Signaling Pathway Map

HER2 Inhibitors with Unique Features

相关HER2产品