Lapatinib (GW-572016) Ditosylate

For research use only. Not for use in humans.

目录号：S1028 中文名称：二苯磺酸拉帕替尼

Lapatinib (GW-572016) Ditosylate Chemical Structure

CAS No. 388082-77-7

Lapatinib (GW-572016) Ditosylate是一种有效的EGFR 和 ErbB2抑制剂，在无细胞试验中IC50分别为10.8和9.2 nM。

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10mM (1mL in DMSO)	RMB 1564.18	现货
25mg	RMB 1214.79	现货
50mg	RMB 2104.83	现货
100mg	RMB 3286.41	现货
200mg	RMB 5487.3	现货
500mg	RMB 9746.1	现货
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客户使用Selleck生产的Lapatinib (GW-572016) Ditosylate发表文献98篇：

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产品安全说明书

HER2抑制剂选择性比较

生物活性

产品描述

Lapatinib (GW-572016) Ditosylate是一种有效的EGFR 和 ErbB2抑制剂，在无细胞试验中IC50分别为10.8和9.2 nM。

靶点

ErbB2 ^[1] (Cell-free assay)	EGFR ^[1] (Cell-free assay)	ErbB4 ^[1] (Cell-free assay)
9.2 nM	10.8 nM	367 nM

体外研究

Lapatinib 微弱抑制ErbB4活性，IC50为367 nM, 作用于EGFR和 ErbB2 比作用于其他激酶，如c-Src, c-Raf, MEK, ERK, c-Fms, CDK1, CDK2, p38, Tie-2,和 VEGFR-2选择性高300多倍。Lapatinib作用于HN5细胞时，显著抑制受体EGFR 和 ErbB2自磷酸化，这种作用存在剂量依赖性，IC50分别为170 nM和80 nM,而作用于BT474细胞时，IC50分别为210 nM 和 60 nM。与OSI-774和Iressa(ZD1839)优先抑制过量表达EGFR细胞生长不同, Lapatinib 抑制过量表达EGFR和ErbB2细胞生长。作用于过量表达EGFR或 ErbB2的细胞具有高抑制活性，IC50为0.09-0.21 μM,而作用于表达低水平EGFR或ErbB2的细胞，IC50为3-12 μM,比作用于正常纤维细胞选择性高100倍。Lapatinib有效抑制过量表达EGFR的HN5和A-431细胞生长，也抑制过量表达ErbB2的BT474和N87细胞生长，且显著诱导HN5细胞周期停在G1期，也诱导 BT474 细胞凋亡，与抑制AKT磷酸化相关。^[1] Lapatinib 作用于含EGFR的L858R和T790M突变的抗Gefitinib的H1975细胞显著抑制Stat3磷酸化，导致细胞生长受抑制，IC50为1-2 μM。^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
HN5 cell line	MWLQdo9tcW[ncnH0bY9vKGG\|c3H5			MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiQNTDj[YxtKGyrbnWsJGlEPTB;MD6wNlUh\|ryP	NE\QWlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkS4N\|c4Oid-MU[0PFM4PzJ:L3G+
BT474 cell line	MknoVJJwdGmoZYLheIlwdiCjc4PhfS=>			M1HDZWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQmS0O\|Qh[2WubDDsbY5mNCCLQ{WwQVAvODJ3IN88US=>	NUDZWm86RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0PFM4PzJpPkG2OFg{Pzd{PD;hQi=>
HN5 cell	NHPpUmpIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MlPDTY5pcWKrdHnvckBw\iCKTkWgZ4VtdCCpcn;3eIgh[W[2ZYKgO\|IhcHK\|LDDJR\|UxRTBwMUKg{txO	NX\hPHg1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[3O\|c1OTBpPkG2O\|c4PDFyPD;hQi=>
BT474 cell	MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MVzJcohq[mm2aX;uJI9nKEKWNEe0JINmdGxiZ4Lve5RpKGGodHXyJFczKGi{czygTWM2OD1yLkC4JO69VQ>?	NFTvbXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNke3O\|QyOCd-MU[3O\|c1OTB:L3G+
N87 cell	MkfMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NYrLUItqUW6qaXLpeIlwdiCxZjDOPFch[2WubDDndo94fGhiYX\0[ZIhPzJiaILzMEBKSzVyPUCuNFgh\|ryP	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd5N{SxNEc,OTZ5N{e0NVA9N2F-
HFF cell	M1L2PGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NWfxW2djUW6qaXLpeIlwdiCxZjDISmYh[2WubDDndo94fGhuIFnDOVA:QS57IN88US=>	NXy3Uml{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[3O\|c1OTBpPkG2O\|c4PDFyPD;hQi=>
BT474	M2jIfGFvfGmycn;sbYZmemG2aY\lJIF{e2G7			NYDueJFFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCWFQ4PCClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFdmIzNCCLQ{WwQVAvODJ3zszN	M1LwS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NkWzN\|M{Lz5zOE[1N\|M{OzxxYU6=
SKBR3	NFSzNJREgXSxdH;4bYNqfHliYYPzZZk>		NIfvZmI4OiCqcoO=	M3LpNWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMSlJ\|IHPlcIx{KGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUC9NE4xOTgQvF2=	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB{OESyOUc,OTlyMki0NlU9N2F-
SKBR3	M2K4S2N6fG:2b4jpZ4l1gSCjc4PhfS=>		M4TlTVczKGi{cx?=	MY\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT2JTOyClZXzsd{Bi\nSncjC3NkBpenNiYomgV3JDKGG\|c3H5MEBKSzVyPUCuNFI6\|ryP	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTh6OEe2NUc,OTl6OEi3OlE9N2F-
A431	M3PTWWN6fG:2b4jpZ4l1gSCjc4PhfS=>		MmTOO\|IhcHK\|	MXLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO\|YYmsJGlEPTB;MD6xNFTPxE1?	M121c\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OEi4O\|YyLz5zOUi4PFc3OTxxYU6=
SK-BR-3	NYKwXVJDSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			MkHmRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCVSz3CVk0{KGOnbHzzJIFnfGW{IHjyd{BjgSCDVGCgZ49vfGWwdDDhd5NigSxiSVO1NF0xNjB2zszN	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{e3PEc,OjBzNEO3O\|g9N2F-
SKHEP1	NED2UJhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			NHTzW3BCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPLTGVROSClZXzsd{Bi\nSncjDodpMh[nliQWTQJINwdnSnboSgZZN{[XluIFnDOVA:PS5\|zszN	NF2xb4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N\|c4QCd-MkCxOFM4Pzh:L3G+
MDA-MB-231	MWLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[W[2ZYKgbJJ{KGK7IFHUVEBkd262ZX70JIF{e2G7LDDJR\|UxRTVwNN88US=>	Ml\tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO3O\|goRjJyMUSzO\|c5RC:jPh?=
Hep3B2	NFTqSldCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincEPCNkBk\WyuczDh[pRmeiCqcoOgZpkhSVSSIHPvcpRmdnRiYYPzZZktKEmFNUC9OU41Qc7:TR?=	NWTyToU5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM4PzhpPkKwNVQ{Pzd6PD;hQi=>
HepG2	Ml;sRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			Mn3LRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiCqcoOgZpkhSVSSIHPvcpRmdnRiYYPzZZktKEmFNUC9Ok4zP87:TR?=	M{nhPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUSzO\|c5Lz5{MEG0N\|c4QDxxYU6=
MCF7	MkjTRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			M3X1fmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiCqcoOgZpkhSVSSIHPvcpRmdnRiYYPzZZktKEmFNUC9Ok43\|ryP	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{e3PEc,OjBzNEO3O\|g9N2F-
A431	NGfOSoVHfW6ldHnvckBie3OjeR?=			NFT4Wo1KdmirYnn0bY9vKG:oIFXHSnIhcW62cnHj[YxtfWyjcjDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iQUSzNUBk\WyuczDifUBGVEmVQTygTWM2OD1yLkC1Nu69VQ>?	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN2Nk[1OUc,OjB\|NE[2OVU9N2F-
N87	NWjqZ\|V1TnWwY4Tpc44h[XO\|YYm=			Mmi1TY5pcWKrdHnvckBw\iCHcnLCNkBqdnS{YXPlcIx2dGG{IIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCQOEegZ4VtdHNiYomgSWxKW0FuIFnDOVA:OC5zzszN	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN2Nk[1OUc,OjB\|NE[2OVU9N2F-
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MDA-MB-435	M1[wZmN6fG:2b4jpZ4l1gSCjc4PhfS=>			Mn7YR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUSzOUBk\WyuczygTWM2OD1yLkCyPVfPxE1?	NXnMcoRsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4PVA3PTJpPkK0PFkxPjV{PD;hQi=>
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MG 63 (6-TG R)	NFLQW3RyUFSVIHHzd4F6			MnzmdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKE2JIE[zJEg3NVSJIGKpJINmdGy\|	M2TFS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
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Sf21	MnGzSpVv[3Srb36gZZN{[Xl?		NE\zZpE2KG2rboO=	MnLLTY5pcWKrdHnvckBw\iCQLYTldo1qdmGuIFfTWE11[WepZXSgdoVkd22kaX7hcpQhcHWvYX6gSWdHWiCWN{mwUUBufXSjboSg[ZhxemW\|c3XkJIlvKGKjY4Xsc5ZqenW\|IHnu[oVkfGWmIGPmNlEhcW6\|ZXP0JINmdGy\|IIDy[Ylv[3WkYYTl[EBnd3JiNTDtbY5{KG[xbHzve4VlKGK7IFHUVEBi\GSrdHnvckBidmRibXXhd5Vz\WRiYX\0[ZIhOzBibXnud{BjgSCKVGLGJIF{e2G7LDDJR\|UxRTBwMkK0PFnPxE1?	NVLKZY42RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVY2QDBpPkOwNFk3PThyPD;hQi=>
MCF7	M{\4RWN6fG:2b4jpZ4l1gSCjc4PhfS=>		MVmyOEBpenN?	NUTtRXhIS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkAzPCCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVUvODMQvF2=	M3XwbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm2OVgxLz5\|MEC5OlU5ODxxYU6=
HCT116	MXTDfZRwfG:6aXPpeJkh[XO\|YYm=		M{\wTFI1KGi{cx?=	NFzpOlNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF02Njl{zszN	NYTLVlNyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwPVY2QDBpPkOwNFk3PThyPD;hQi=>
HepG2	M3HKfWN6fG:2b4jpZ4l1gSCjc4PhfS=>		MWeyOEBpenN?	MVPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCyOEBpenNiYomgV3JDKGG\|c3H5MEBKSzVyPUGxMlcy\|ryP	NGL1eHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEC5OlU5OCd-M{CwPVY2QDB:L3G+
Caco	MVXDfZRwfG:6aXPpeJkh[XO\|YYm=		NV7kT\|RVOjRiaILz	M3;pb2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNi[29iY3XscJMh[W[2ZYKgNlQhcHK\|IHL5JHNTSiCjc4PhfUwhUUN3ME2xNk4yOc7:TR?=	MkLmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOU[1PFAoRjNyMEm2OVgxRC:jPh?=
HepG2	NV\6RWtbS3m2b4TvfIlkcXS7IHHzd4F6			NVvX[\|I1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNuIGTDOVA:Pi5\|zszN	M3TqWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyM{S0PVA3Lz5\|MEO0OFkxPjxxYU6=
L929	NGDCcYNEgXSxdH;4bYNqfHliYYPzZZk>		NELuPI04OiCqcoO=	M{XT[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGw6OjliY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUKuNFXPxE1?	NHjZRVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEWwPFM4QSd-M{C1NFg{Pzl:L3G+
A431	M2HGbWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MlrEO\|IhcHK\|	M3zPWWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUSzNUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTJwNkdOwG0>	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODVyOEO3PUc,OzB3MEizO\|k9N2F-
A549	MVzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MkS0O\|IhcHK\|	NVrLVpRCSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;Mz62OO69VQ>?	M4L4WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyNUC4N\|c6Lz5\|MEWwPFM4QTxxYU6=
A549	NFntR4REgXSxdH;4bYNqfHliYYPzZZk>	M2DHe\|YhfU1?	NEjabIwzPCCqcoO=	NF;UUnlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG\|c3Xzd4VlKGG\|IHXm[oVkfCCxbjDpcpRz[WOnbHz1cIFzKEGWUDDs[ZZmdHNiYYSgOkB2VSCjZoTldkAzPCCqcoOgZpkhdHWlaX\ldoF{\S2udXPp[oVzcW5iYnHz[YQh[XO\|YYm=	MlvFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB3MEizO\|koRjNyNUC4N\|c6RC:jPh?=
HN5	MXjGeY5kfGmxbjDhd5NigQ>?		NY\MXoIxOjRiaILz	M4jwVWlvcGmkaYTpc44hd2ZiRVfGMYlv\HWlZXSgSWdHWiCyaH;zdIhwenmuYYTpc44h[XRiVInyMZJme2mmdXWgbY4hcHWvYX6gTG42KGOnbHzzJJBz\WmwY4XiZZRm\CCob4KgNlQhcHK\|IH\vcIxwf2WmIHL5JGVITi2\|dHnteYxifGmxbjDhcoQhdWWjc4Xy[YQh[W[2ZYKgNVUhdWmwczDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXNuIFnDOVA:OC5yMd88US=>	M3[5blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyNkCwNVQ6Lz5\|ME[wNFE1QTxxYU6=
MCF7	NELPdoNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NIqw[4I4OiCqcoO=	NYjPSYFwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;ND62PVHPxE1?	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODd7MkGwNUc,OzB5OUKxNFE9N2F-
MDA231	M3rLS2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		MnTOO\|IhcHK\|	MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQUKzNUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTRwNkmx{txO	MkfDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB5OUKxNFEoRjNyN{myNVAyRC:jPh?=
SK-MEL-19	NXq1O2lRSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NEDaZoE4OiCqcoO=	MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFONLV3FUE0yQSClZXzsd{BqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKGy3bXnu[ZNk\W6lZTDhd5NigSxiR1m1NF02\|ryP	M{\rclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOECyO\|MxLz5\|MEiwNlc{ODxxYU6=
JeKo1	MXXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NVjKWWc6PzJiaILz	MUfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEqnS3:xJINmdGy\|IHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gcJVucW6nc3PlcoNmKGG\|c3H5MEBIUTVyPUZOwG0>	NXjUb3BORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C4NFI4OzBpPkOwPFAzPzNyPD;hQi=>
MIAPaCa2	NE\Z[4pCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M4ryWVczKGi{cx?=	NILsfIRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3JRXBiS2F{IHPlcIx{KGmwY4XiZZRm\CCob4KgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ibIXtbY5me2OnbnPlJIF{e2G7LDDHTVUxRTFyzszN	NIjJV4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEiwNlc{OCd-M{C4NFI4OzB:L3G+
U87MG	M2X6VmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NUXr[YRmPzJiaILz	NWPpSnJQSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVPFdOTyClZXzsd{BqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKGy3bXnu[ZNk\W6lZTDhd5NigSxiR1m1NF0yOM7:TR?=	NEf5S2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEiwNlc{OCd-M{C4NFI4OzB:L3G+
MV4-11	M2fuVGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MUK3NkBpenN?	NGPyeHVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3WOE0yOSClZXzsd{BqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKGy3bXnu[ZNk\W6lZTDhd5NigSxiR1m1NF0yOM7:TR?=	NFT5VJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEiwNlc{OCd-M{C4NFI4OzB:L3G+
DU145	MYDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NHPp[GM4OiCqcoO=	MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKESXMUS1JINmdGy\|IHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gcJVucW6nc3PlcoNmKGG\|c3H5MEBIUTVyPUKw{txO	M4PPeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOECyO\|MxLz5\|MEiwNlc{ODxxYU6=
HCT116	MnX5RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NFf3V3E4OiCqcoO=	MnrJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKQ2SxNVYh[2WubIOgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BtfW2rbnXzZ4Vv[2ViYYPzZZktKEeLNUC9NlDPxE1?	MnTaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB6MEK3N\|AoRjNyOECyO\|MxRC:jPh?=
MDA-MB-231	NWG2eWk2SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NX70OVZyPzJiaILz	M17zU2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ\|MTDj[YxteyCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIHz1cYlv\XOlZX7j[UBie3OjeTygS2k2OD1{MN88US=>	Mkj0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB6MEK3N\|AoRjNyOECyO\|MxRC:jPh?=
T47D	MkHjRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MnH1O\|IhcHK\|	NEGyfG9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGS0O2Qh[2WubIOgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BtfW2rbnXzZ4Vv[2ViYYPzZZktKEeLNUC9OFDPxE1?	MnTtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB6MEK3N\|AoRjNyOECyO\|MxRC:jPh?=
A431	NF3rd5dHfW6ldHnvckBie3OjeR?=		MV25NEBucW6\|	M1PlemlvcGmkaYTpc44hd2ZiRVfGVkBqdiCqdX3hckBCPDNzIHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBGT0Zvc4TpcZVt[XSnZDDFS2ZTKGG3dH;wbI9{eGixconsZZRqd25icILlbY5kfWGkdHXkJIZweiB7MDDtbY5{KG[xbHzve4VlKGK7IFXHSk1{fGmvdXzheIlwdiCkeTDzZY5lf2mlaD3FUGlUSSxiSVO1NF0xNjB{Md88US=>	NFi5Npc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEm3N\|c{PSd-M{C5O\|M4OzV:L3G+
UCH1	MnvMRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NVXRd4JvPzJiaILz	NILXOGtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGXDTFEh[2WubIOgcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IHHsZY1ieiCkbIXlJIF{e2G7LDDJR\|UxRTNwMt88US=>	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODl5M{ezOUc,OzB7N{O3N\|U9N2F-
WS1	MYnDfZRwfG:6aXPpeJkh[XO\|YYm=		NVLlTlhWPzJiaILz	NWjnXYdJS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hX1NzIHPlcIx{KG2nYYP1doVlKGGodHXyJFczKGi{czDifUBidGGvYYKgZox2\SCjc4PhfUwhUUN3ME2xN:69VQ>?	NXPSTY5IRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C5O\|M4OzVpPkOwPVc{PzN3PD;hQi=>
UMCHOR1	M2LmWWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NHXve4U4OiCqcoO=	M{ToV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iVV3DTG9TOSClZXzsd{Bu\WG\|dYLl[EBi\nSncjC3NkBpenNiYomgZYxidWG{IHLseYUh[XO\|YYmsJGlEPTB;MkZOwG0>	NV3rOo1bRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C5O\|M4OzVpPkOwPVc{PzN3PD;hQi=>
CH22	NUP2ZZlbSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MXe3NkBpenN?	MkDMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCFSEKyJINmdGy\|IH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCjbHHtZZIh[my3ZTDhd5NigSxiSVO1NF0zPc7:TR?=	NXrBOJVkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C5O\|M4OzVpPkOwPVc{PzN3PD;hQi=>
UCH7	MXTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M{DaNVczKGi{cx?=	NY\4NY03SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVR2g4KGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJiYnz1[UBie3OjeTygTWM2OD1{Nt88US=>	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODl5M{ezOUc,OzB7N{O3N\|U9N2F-
UCH12	MUHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NYLJdpVnPzJiaILz	NFjHdolCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGXDTFEzKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJiYnz1[UBie3OjeTygTWM2OD1\|M988US=>	NWjrU3N6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C5O\|M4OzVpPkOwPVc{PzN3PD;hQi=>
A549	NFXmUJVHfW6ldHnvckBie3OjeR?=	NY\zS3E{QDZibV2vb4c>	M4nEPVI4KGSjeYO=	MlrpSJJ2\yClb37j[Y51emG2aX;uJIlvKE6RRD;TR2lFKG2xdYPlJIJtd2:mIIjlco9oemGodHXkJJdqfGhiaIXtZY4hSTV2OTDj[YxteyCxdnXy[ZhxemW\|c3nu[{BGT0[UIHH0JFg3KG2rY4LvcY9tN2upLDDwc{Bi\G2rbnnzeIVz\WRib37j[UBl[WmueTDmc5IhOjdiZHH5d{BidmRibXXhd5Vz\WRiYYSg[IF6KDJ5IHH0JFIhcHK\|IHHmeIVzKGyjc4SgZYRucW6rc4TldoVlKGSxc3WgZpkhVENvTWOvUXMh[W6jbInzbZMtKEO2PUKuPFHPxE1?	NFzWTHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUGyOVg6PCd-M{GxNlU5QTR:L3G+
HCC1954	M3vTVWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M2Pmc\|czKGi{cx?=	MYfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFQ{G5OVQh[2WubIOgc5ZmemW6cILld5NqdmdiSFXSNkBie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVXPxE1?	M2\xVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMUK1PFk1Lz5\|MUGyOVg6PDxxYU6=
NCI-H1975	NIL4R\|NCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M2Djd\|czKGi{cx?=	NXfVe4doSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDF7N{WgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD17zszN	Mny5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzMkW4PVQoRjNzMUK1PFk1RC:jPh?=
A549	MmWyRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M{XjXlczKGi{cx?=	MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUGx{txO	NHHuNlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUGyOVg6PCd-M{GxNlU5QTR:L3G+
Sf9	NVXjSmVtTnWwY4Tpc44h[XO\|YYm=	MVexJJRwKDFyIIXN	MWm2NEBucW6\|	MUnJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEeVVD30ZYdo\WRiRVfGVkAp[2G2YXz5eIlkKGSxbXHpckA3QTVidH:g[Y5lKHKnc3nkeYV{MSCjdYTvdIhwe3Cqb4L5cIF1cW:wIHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCrbn\lZ5Rm\CCVZkmgZ4VtdHNidYPpcocheG:ueTigS4x2NFS7cjmgOFoyKGG\|IIP1ZpN1emG2ZTDheEAyKHSxIEGwJJVOKGmwY4XiZZRm\CCob4KgOlAhdWmwczDifUBGVEmVQR?=	NYLGTlJNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNlU5QTRpPkOxNVI2QDl2PD;hQi=>
HCC1954	NX70TppsTnWwY4Tpc44h[XO\|YYm=	MUiwMlAzKHSxIEKgeW0>	MWOxJIhz	MlW4TY5pcWKrdHnvckBw\iCKRWKyJIF2fG:yaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hUEOFMUm1OEBk\WyuczDveoVz\XiycnXzd4lv\yCKRWKyJIF1KDBwMEKgeI8hOiC3TTDpcoN2[mG2ZXSg[o9zKDFiaIKgZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTF{NUi5OEc,OzFzMkW4PVQ9N2F-
HCC827	M3S0WmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M1r3W\|czKGi{cx?=	NHnIT5BCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDR\|gzPyClZXzsd{BqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;MD62{txO	NGr6clI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUKwNlk6OCd-M{GyNFI6QTB:L3G+
A431	NGHhR\|JCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MXG3NkBpenN?	NWH3fY5pSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD12LklOwG0>	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTJyMkm5NEc,OzF{MEK5PVA9N2F-
SW480	M4TtbWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M1XjSlczKGi{cx?=	M2TsXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU2e0PFAh[2WubIOgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTF{LkW4{txO	M2O4[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMkCyPVkxLz5\|MUKwNlk6ODxxYU6=
NCI-H1975	NGLIWnRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MnfJO\|IhcHK\|	Ml;JRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCQQ1mtTFE6PzViY3XscJMhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUGyMlY5\|ryP	NX;l[lRLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyNFI6QTBpPkOxNlAzQTlyPD;hQi=>
A549	MYjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MmH6O\|IhcHK\|	NInaRlFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTF2LkpOwG0>	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTJyMkm5NEc,OzF{MEK5PVA9N2F-
A549	MofsSpVv[3Srb36gZZN{[Xl?	NE[yT\|EyPSC3TR?=	NYfr[HRnPDhiaILz	NYjLOo5YUW6qaXLpeIlwdiCxZjDj[YxtKG2rZ4LheIlwdiCrbjDDUU1lcWxvbHHi[Yxt\WRiaIXtZY4hSTV2OTDj[YxteyC6ZX7v[5Ji\nSnZDDpckA1QCCqcoOgdI9{fC2oZYL0bYxqgmG2aX;uJJpm[nKjZnnzbEBmdWK{eX;zJIF1KDF3IIXNJIlv[3WkYYTl[EBnd3JiNEigbJJ{KGK7IHPvcoZw[2GuIH3pZ5Jwe2OxcHnjJI1mfGixZB?=	NWnoXpVSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyNFI6QTBpPkOxNlAzQTlyPD;hQi=>
WS1	NIjiXZJEgXSxdH;4bYNqfHliYYPzZZk>			MU\DfZRwfG:6aXPpeJkhcW5iaIXtZY4hX1NzIHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDpcoN2[mG2ZXSg[pJwKDR6IHjyd{BjgSCjbHHtZZIh[my3ZTDkfYUh[mG\|ZXSgZZN{[XluIFnDOVA:OTQQvF2=	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTN5OEW3NUc,OzF\|N{i1O\|E9N2F-
SKBR3	MYTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MkHEO\|IhcHK\|	MnS4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCVS1LSN{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME25Mlc3\|ryP	NV21d\|ZDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1OFYyQTdpPkOxOVQ3OTl5PD;hQi=>
SUM159	NYPoPWZRSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MYO3NkBpenN?	M1zGNmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU2XNNVU6KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVkvPzcQvF2=	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTV2NkG5O{c,OzF3NE[xPVc9N2F-
KG1a	M37mU2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		MVm3NkBpenN?	M4nzc2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS1exZUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME25Mlc3\|ryP	NFzU[ZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUW0OlE6Pyd-M{G1OFYyQTd:L3G+
MCF7	NVPP[4U1SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MXO3NkBpenN?	MlvGRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPQ1[3JINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Pi56zszN	NHSyd5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MU[1OVQzQSd-M{G2OVU1Ojl:L3G+
A2780	NVG1T3d3SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NFWyNIo4OiCqcoO=	M{jJNmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUK3PFAh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zMD60{txO	NIT2OFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MU[1OVQzQSd-M{G2OVU1Ojl:L3G+
HT-29	NVnxeHo2SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		Mlj0O\|IhcHK\|	MoD0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKVD2yPUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTF{Lk[3{txO	NFrtXXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MU[1OVQzQSd-M{G2OVU1Ojl:L3G+
MRC5	M1\jV2N6fG:2b4jpZ4l1gSCjc4PhfS=>		M3;ve\|czKGi{cx?=	MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNVmM2KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;MUOuOlbPxE1?	NGLVN\|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MU[1OVQzQSd-M{G2OVU1Ojl:L3G+
NCI-H1648 cell	NFu0cZBIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NGnNbWhKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVY1QCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTBwMEK1OFQh\|ryP	M3q0SVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
NMC-G1 cell	MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NHzHdXZKdmirYnn0bY9vKG:oIHj1cYFvKE6PQz3HNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvPTR3MEGg{txO	NXfHRZBDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
NTERA-S-cl-D1 cell	NELocmhIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M4\RZ2lvcGmkaYTpc44hd2ZiaIXtZY4hVlSHUlGtV{1kdC2GMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPU[uNlY2PjFizszN	M3foTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
OCUB-M cell	MmTCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M{\MV2lvcGmkaYTpc44hd2ZiaIXtZY4hV0OXQj3NJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xPTd2IN88US=>	NXOzNoNnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
OS-RC-2 cell	Ml71S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MUXJcohq[mm2aX;uJI9nKGi3bXHuJG9UNVKFLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlk6OTl7IN88US=>	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
OVCAR-4 cell	NEXoSmlIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MWHJcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GULUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlEyPjd3IN88US=>	M3qwbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
RL95-2 cell	MlP3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M3f6XmlvcGmkaYTpc44hd2ZiaIXtZY4hWkx7NT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4yPTZ5IN88US=>	NYjWRZloRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
SW954 cell	MlroS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MnHaTY5pcWKrdHnvckBw\iCqdX3hckBUXzl3NDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUWuN\|kzPDVizszN	M3;qZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
SW962 cell	NHLVdIlIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M{jaemlvcGmkaYTpc44hd2ZiaIXtZY4hW1d7NkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlM6OjR3IN88US=>	M4[4cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
TE-1 cell	Mk\PS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MYHJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13LkCyNVU6KM7:TR?=	NE[2U2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
A253 cell	NVizN3ZzT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			MYPJcohq[mm2aX;uJI9nKGi3bXHuJGEzPTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkC0PFMh\|ryP	M3mwdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
A388 cell	MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NYDEPYZrUW6qaXLpeIlwdiCxZjDoeY1idiCDM{i4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4xPDh\|IN88US=>	M1TsdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
BB30-HNC cell	NFS5R\|BIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MVnJcohq[mm2aX;uJI9nKGi3bXHuJGJDOzBvSF7DJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PzN\|NTFOwG0>	NFLB[5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
TE-12 cell	NHjU[phIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MYLJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MD63NlI2QCEQvF2=	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
TE-5 cell	M2D2dmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			M1X0fGlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUCuNlQ3PTRizszN	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
TE-6 cell	NXr2RW9ST3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NYj3cmdpUW6qaXLpeIlwdiCxZjDoeY1idiCWRT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE41QTB3NzFOwG0>	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
TE-8 cell	NH7LRpdIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			Mlr0TY5pcWKrdHnvckBw\iCqdX3hckBVTS16IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;ND6wN\|c{KM7:TR?=	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
TE-9 cell	MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MlPqTY5pcWKrdHnvckBw\iCqdX3hckBVTS17IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MT61OVIxOSEQvF2=	M132UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
TK10 cell	NY[wc\|dUT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NET1WJdKdmirYnn0bY9vKG:oIHj1cYFvKFSNMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlE3PTJ{IN88US=>	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
DSH1 cell	NV;tbYZPT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			MWjJcohq[mm2aX;uJI9nKGi3bXHuJGRUUDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkC5N\|k3KM7:TR?=	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
ECC12 cell	NWfYZplbT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NU\JfVFqUW6qaXLpeIlwdiCxZjDoeY1idiCHQ1OxNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODl{M{Gg{txO	M1nwOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
EKVX cell	NW[xO25VT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			Mn6wTY5pcWKrdHnvckBw\iCqdX3hckBGU1[[IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MD60OFg4PCEQvF2=	Mm[4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
HCC2218 cell	MmfTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NVO0cYJlUW6qaXLpeIlwdiCxZjDoeY1idiCKQ1OyNlE5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yNUOyOkDPxE1?	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
LB2241-RCC cell	NHvRTHhIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MYfJcohq[mm2aX;uJI9nKGi3bXHuJGxDOjJ2MT3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjF3NECzJO69VQ>?	NXTWZW91RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
LB996-RCC cell	M3e3N2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MWjJcohq[mm2aX;uJI9nKGi3bXHuJGxDQTl4LWLDR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOzZ{Mkig{txO	NIjmUlY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
LC-1F cell	Mke5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			MUDJcohq[mm2aX;uJI9nKGi3bXHuJGxENTGIIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MT6zPFI1PCEQvF2=	MmTmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
LS-513 cell	MnLPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NInXZ29KdmirYnn0bY9vKG:oIHj1cYFvKEyVLUWxN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvPDByNEGg{txO	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-ErbB2 / t-ErbB2 / p-Akt / t-Akt / p-Erk / t-Erk; PubMed: 25238247 PLoS One Dose response of lapatinib and PD168393 on phosphorylation of ErbB2, AKT and ERK in Calu3 and SkBr3 cells in response to EGF treatment. p-ErbB2: phosphorylated ErbB2; t-ErbB2: total-ErbB2; p-AKT: phosphorylated AKT; t-AKT: total AKT; p-ERK: phosphorylated ERK; t-ERK: total ERK. pEGFR / EGFR / p-mTOR / mTOR / PARP / c-PARP ; PubMed: 28938602 Oncotarget SKBR3 and 78617 cells were treated with lapatinib as in panel A, then the expression of phospho-ErbB2 (Tyr1221/1222), ErbB2, phospho-EGFR (Tyr1068), EGFR, phospho-Akt (Ser473), Akt, phospho-Erk1/2 (Thr202/Tyr204), Erk2, phospho-mTOR (Ser2448), and mTOR were analyzed using Western blotting. All values are presented as the mean ± standard error (S.E.) (**p < 0.01).	25238247 28938602
Growth inhibition assay	Cell viability ; PubMed: 24947784 Oncotarget Huh7 (A), HepG2 (B), or HA22T (C) HCC cells were left untreated or treated with 0.1% DMSO (vehicle, D) or with DMSO containing various concentrations of lapatinib (1.25, 2.5, 5, or 10 μM) for 3 days. Relative amounts of viable cells were detected by MTS assay. O.D. values from DMSO-treated control cells were designated 100%.	24947784

体内研究

Lapatinib 按~100 mg/kg剂量口服处理，每天两次，显著抑制BT474和HN5移植瘤生长，这种作用存在剂量依赖性。^[1] 与在体外活性一致，Lapatinib按100-150 mg/kg剂量处理携带H1975肿瘤的小鼠，延迟肿瘤生长。^[3]

激酶实验：^[1]	- 合并体外激酶实验: 通过测量抑制肽底物磷酸化的情况而获得抑制酶活性的IC50值。通过杆状病毒表达系统纯化EGFR 和 ErbB2的细胞外激酶域。在96孔圆底板上进行EGFR和ErbB2反应，终体积为45 μL。反应混合物含50 mM 4-吗啉丙磺酸(pH 7.5), 2 mM MnCl₂, 10 μM ATP, 1 μCi [γ³³P] ATP/每次反应, 50 μM 肽 A [生物素-(氨基)-EEEEYFELVAKKK-CONH2], 1 mM 二流苏糖醇，及 1 μL DMSO（含连续稀释的Lapatinib，起始浓度为10 μM）。加入指定纯化的 1型受体胞内域，开始反应。加入的酶量为为1 pmol/每组反应(20 nM)在23^oC下反应10分钟，加入45 μL 0.5%溶于水的磷酸，终止反应。终止反应混合物(75 μL) 转移到磷酸纤维过滤板上。板过滤，然后使用200 μL 0.5% 磷酸冲洗3次。每孔加入闪烁剂(50 μL) , 在Packard Topcount上测量每组反应。通过10点剂量反应曲线获得IC50值。
细胞实验：^[1]	- 合并 Cell lines: HFF, MCF-7, T47D, A-431, HN5, BT474, N87, CaLu-3, HB4a, 和 HB4a c5.2 Concentrations: 溶于 DMSO,终浓度为~100 μM Incubation Time: 72小时 Method: 使用不同浓度Lapatinib处理细胞72小时。使用亚甲基蓝染色测定相对细胞数。使用Spectra酶标仪在620 nm 处测定吸光值。通过碘化丙啶染色和渗透BrdUrd的抗体检测，测量细胞死亡和细胞周期分析。 (Only for Reference)
动物实验：^[1]	- 合并 Animal Models: 皮下移植HN5细胞的CD-1雌性裸鼠,皮下移植BT474细胞的 C.B-17 SCID 雌性小鼠 Dosages: ~100 mg/kg Administration: 口服处理，每天两次 (Only for Reference)

参考文献

[1] Rusnak DW, et al. Mol Cancer Ther, 2001, 1(2), 85-94.

溶解度 (25°C)

体外	DMSO	100 mg/mL (108.05 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 2% DMSO+40% PEG 300+5% Tween 80+53% ddH2O	1.25 mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Lapatinib (GW-572016) Ditosylate SDF

分子量	925.46
化学式	C₂₉H₂₆ClFN₄O₄S.2C₇H₈O₃S
CAS号	388082-77-7
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04608409	Recruiting	Drug: Lapatinib and Paclitaxel	Ovarian Cancer	Frederick R. Ueland M.D.\|University of Kentucky	November 16 2020	Phase 1
NCT03075995	Unknown status	Other: hight-fat breakfast	Breast Cancer	Sun Yat-sen University	April 12 2017	Not Applicable
NCT02338245	Completed	Drug: ASLAN001\|Drug: Lapatinib\|Drug: Capecitabine	Metastatic Breast Cancer	Aslan Pharmaceuticals	December 29 2014	Phase 2
NCT02294786	Terminated	Drug: Lapatinib\|Drug: Capecitabine\|Drug: Octreotide	Cancer	Novartis Pharmaceuticals\|Novartis	December 17 2014	Phase 2
NCT02213042	Completed	Drug: Lapatinib\|Biological: Trastuzumab	Neoplasms Breast	Novartis Pharmaceuticals\|Novartis	October 24 2014	Phase 2
NCT02158507	Active not recruiting	Drug: Combination of Veliparib + Lapatinib	Metastatic Triple Negative Breast Cancer	University of Alabama at Birmingham\|Scariot Foundation\|GlaxoSmithKline\|AbbVie	September 2014	Not Applicable

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
If I need to use S1028 for treating tumor-bearing mice with injection, how could I prepare the solution?
回答：
S1028 Lapatinib Ditosylate can be dissolved in 2% DMSO/30% PEG 300/ddH2O at 10 mg/ml as clear solution.

HER2 Signaling Pathway Map

HER2 Inhibitors with Unique Features

选择性强的EGFR抑制剂

Erlotinib HCl (OSI-744) : EGFR-selective, IC50=2 nM.
活性最高的EGFR抑制剂

Afatinib (BIBW2992) : EGFR(wt), IC50=0.5 nM; EGFR(L858R), IC50=0.4 nM; EGFR(L858R/T790M), IC50=10 nM; HER2, IC50=14 nM.
FDA批准的EGFR抑制剂

Lapatinib : Approved by FDA for breast cancer.
最新的EGFR抑制剂

CO-1686 (AVL-301) ^New : Irreversible, mutant-selective EGFR inhibitor with K_i of 21.5 nM and 303.3 nM for EGFRL858R/T790M and EGFRWT, respectively.

研究领域

产品类型

定制您的化合物库

Lapatinib (GW-572016) Ditosylate

客户使用Selleck生产的Lapatinib (GW-572016) Ditosylate发表文献98篇：

产品安全说明书

HER2抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Lapatinib (GW-572016) Ditosylate SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-09-06)

技术支持

常见问题及建议解决方法

HER2 Signaling Pathway Map

HER2 Inhibitors with Unique Features

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