Nilotinib (AMN-107)

目录号:S1033 别名: AMN-107 中文名称:尼洛替尼

仅限科研使用

Nilotinib (AMN-107)是一种特异性BCR-ABL抑制剂,在小鼠骨髓祖细胞中IC50低于30 nM。Nilotinib (AMN-107)可通过激活AMPK来诱导自噬。

Nilotinib (AMN-107) Chemical Structure

CAS: 641571-10-0

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 749.92 现货
RMB 810.81 现货
RMB 1720.01 现货
大包装 有超大折扣

今日订购,明日送达 全国免运费 分装免费 分装成小规格产品(单支最小为1mg)
如1支10mg产品可分装为10支1mg产品

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客户使用Selleck生产的Nilotinib (AMN-107)发表文献123篇:

产品安全说明书

Bcr-Abl抑制剂选择性比较

相关Bcr-Abl产品

生物活性

产品描述 Nilotinib (AMN-107)是一种特异性BCR-ABL抑制剂,在小鼠骨髓祖细胞中IC50低于30 nM。Nilotinib (AMN-107)可通过激活AMPK来诱导自噬。
特性 Nilotinib 是Abl选择性抑制剂,与BCR-ABL的ATP结合位点相互作用。
靶点
Bcr-Abl [1]
(Murine myeloid progenitor cells)
<30 nM
体外研究

Nilotinib 作用于激活的HSCs,抑制增殖,迁移,和肌动蛋白形成,及 α-SMA和胶原的表达。Nilotinib 诱导HSCs凋亡,与bcl-2 表达降低相关,且提高p53 表达, PARP分裂,以及提高 PPARγ 和TRAIL-R表达。Nilotinib 也诱导细胞周期停滞,伴随着p27 的表达和cyclin D1的下调提高。Nilotinib 不仅抑制PDGFR的激活,也 通过Src抑制TGFRII。Nilotinib 显著抑制PDGF和 TGFβ刺激的ERK 和Akt磷酸化。而且, Nilotinib作用于人HSCs,抑制PDGF和TGFβ-激活的Abl磷酸化形式。 [2]Nilotinib抑制最抗 Imatinib的BCR-ABL突变,除了T315I。[3] Nilotinib 抑制PDGF-DD调节的 ERK1/2激活,基本的和PDGF-DD调节的 PDGFR-β和AKT激活,及schwannoma细胞增殖。 Nilotinib 比Imatinib更有效,发挥其最大抑制效果时的浓度比稳态血浆水平还低。[4] Nilotinib也显著降低TGF-β1和血小板衍生的生长因子(PDGF)基因表达水平。Nilotinib处理也显著抑制PDGF诱导的肺纤维细胞增殖。[5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell M{GxWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jXN2lEPTB;MD6wNFAyPDRizszN M1;XeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PTh4Mz:nQnNCVkeHUkyvZV4>
KU812 NF\E[FJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMECyOFgh|ryP MnPZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU2QDZ|Lze+V2FPT0WUPD;hQi=>
EM-2 NHP5WpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMEC0NUDPxE1? NELzN5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTV6NkOvK|5USU6JRWK8M4E,
LAMA-84 NFHsTZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMEC0PUDPxE1? MlfKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU2QDZ|Lze+V2FPT0WUPD;hQi=>
MEG-01 NVrifYpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrBO|BmUUN3ME2wMlAxQDJ6IN88US=> NF7IbmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTV6NkOvK|5USU6JRWK8M4E,
BV-173 M2TLVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvoTWM2OD1yLkCxNFg6KM7:TR?= M3PLOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PTh4Mz:nQnNCVkeHUkyvZV4>
KASUMI-1 NVuwZVA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{L0WGlEPTB;MD6wNlQyOyEQvF2= M2X2eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PTh4Mz:nQnNCVkeHUkyvZV4>
NB7 NHjybnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnjTWM2OD1yLkGzOFM6KM7:TR?= NIryTW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTV6NkOvK|5USU6JRWK8M4E,
BHT-101 Mn3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwNkSyOlMh|ryP MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVU5PjNxJ{7TRW5ITVJ:L3G+
CGTH-W-1 NXy4Rol7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwNkS4O{DPxE1? NULsPXVoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV3OE[zM{c,W0GQR1XSQE9iRg>?
HMV-II MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7DTWM2OD1yLke0PFc1KM7:TR?= M{TIc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PTh4Mz:nQnNCVkeHUkyvZV4>
NKM-1 MnLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XJTGlEPTB;MD65NFE2KM7:TR?= Mn7LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU2QDZ|Lze+V2FPT0WUPD;hQi=>
LB2241-RCC NIno[ndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHMXFRrUUN3ME2xMlAzOjJ6IN88US=> MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVU5PjNxJ{7TRW5ITVJ:L3G+
NCI-H1703 M4rvR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;GTWM2OD1zLkG4PFch|ryP MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVU5PjNxJ{7TRW5ITVJ:L3G+
BE-13 M{jPNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\ReGlEPTB;MT6yO|QyPiEQvF2= NYrsPYZYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV3OE[zM{c,W0GQR1XSQE9iRg>?
ACN NX\xWZc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPGTWM2OD1zLkW1NFc4KM7:TR?= NU\BWmc5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV3OE[zM{c,W0GQR1XSQE9iRg>?
A204 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk[1TWM2OD1zLkW3NlA2KM7:TR?= Ml[3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU2QDZ|Lze+V2FPT0WUPD;hQi=>
HOP-62 M3Px[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XGXGlEPTB;MT64NlA4PyEQvF2= M1n5[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PTh4Mz:nQnNCVkeHUkyvZV4>
H9 M4HheWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWr4PWRqUUN3ME2yMlc{Pzl|IN88US=> NV\nZ|FDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV3OE[zM{c,W0GQR1XSQE9iRg>?
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NOS-1 MnO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXMSGdFUUN3ME2yMlg4OTB{IN88US=> M1;P[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PTh4Mz:nQnNCVkeHUkyvZV4>
RS4-11 M1HKeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jwZ2lEPTB;Mj65NFYzOyEQvF2= M3P3elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PTh4Mz:nQnNCVkeHUkyvZV4>
JAR NIfUU2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTJwOUKwPFQh|ryP NWjkbG5pRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV3OE[zM{c,W0GQR1XSQE9iRg>?
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SK-MEL-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTNwNEOwNlkh|ryP NHr6VY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTV6NkOvK|5USU6JRWK8M4E,
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SW982 M3v5cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkixTWM2OD1|Lk[0NVY6KM7:TR?= NYraWnA5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV3OE[zM{c,W0GQR1XSQE9iRg>?
HT-1080 MnTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\6T45xUUN3ME2zMlkyPzd3IN88US=> M3;lTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PTh4Mz:nQnNCVkeHUkyvZV4>
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HAL-01 MlHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTRwOEiyOFIh|ryP MnfXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU2QDZ|Lze+V2FPT0WUPD;hQi=>
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LCLC-103H MmrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rMTmlEPTB;NT63O|Q4OSEQvF2= NVjlTW83RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV3OE[zM{c,W0GQR1XSQE9iRg>?
RVH-421 MoLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoOxTWM2OD13Lke3OVM3KM7:TR?= NV21cnA1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV3OE[zM{c,W0GQR1XSQE9iRg>?
K-562 NVrn[4VCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTVwOUCzOkDPxE1? M3LidFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PTh4Mz:nQnNCVkeHUkyvZV4>
CAL-33 MlLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWD2OmQzUUN3ME22MlMyOzV7IN88US=> MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVU5PjNxJ{7TRW5ITVJ:L3G+
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HEK293 MkX3SpVv[3Srb36gZZN{[Xl? MVSwMlEhfG9iMTD1US=> NHXwXngyPiCqcoO= MWjJcohq[mm2aX;uJI9nKGOxbHzh[4VvKElvaX7keYNm\CCGRGKyJGk3OziIIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHCqb4PwbI9zgWyjdHnvckBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJIF1KDBwMTD0c{AyKHWPIHHmeIVzKDF4IHjyd{BjgSCZZYP0[ZJvKGKub4T0bY5o MnzXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzOUGzOlkoRjJ4MUmxN|Y6RC:jPh?=
SJ-GBM2 NYDoWmM3eUiWUzDhd5NigQ>? MX\xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0pvR1LNNkBk\Wyucx?= NGWxN3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
NB-EBc1 NV7TXXlUeUiWUzDhd5NigQ>? NYPTRlJYeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IF7CMWVD[zFiY3XscJM> NX\qOHF2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
NB1643 NXHjSIM3eUiWUzDhd5NigQ>? NViyWo85eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhVkJzNkSzJINmdGy| MnzFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
A673 NW\sOWVpeUiWUzDhd5NigQ>? MmLkdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgRVY4OyClZXzsd{k> NHf3cmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
LAN-5 M4n3eZFJXFNiYYPzZZk> M3Tsc5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGxCVi13IHPlcIx{ M{eySlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
BT-37 NX7tXoNXeUiWUzDhd5NigQ>? MVHxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDCWE0{PyClZXzsdy=> MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
Rh41 NVrVXGpMeUiWUzDhd5NigQ>? MX;xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDSbFQyKGOnbHzz Mk\jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
Rh30 M4fJdJFJXFNiYYPzZZk> MnjhdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgVog{OCClZXzsdy=> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
OHS-50 MmLwdWhVWyCjc4PhfS=> M1WzNJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJG9JWy13MDDj[Yxtew>? M{X0UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-SH MWPxTHRUKGG|c3H5 NXnKUGpSeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhW0tvTj3TTEBk\Wyucx?= NEXwUms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
Assay
Methods Test Index PMID
Western blot p-AMPKα / AMPKα / p-AMPKβ1 / AMPKγ2 / p-LKB1 / LKB1 / CaMKIIβ DNMT1 / DNMT3a / DNMT3b pABL1 / p-NF-κB1 / NF-κB / STAT3 / p-STAT3 / IL-1β / IL-6 / COX2 23677989 28720666 31396300
Growth inhibition assay Cell viability 23677989
体内研究 Nilotinib 作用于CCl4和BDL诱导的纤维化,降低胶原沉积和α-SMA表达。 Nilotinib 可以诱导HSC发生凋亡,与bcl-2的下调相关。 [2] Nilotinib轻肺损伤和纤维化程度。Nilotinib 疗法在第14天和21天,显著降低羟脯氨酸水平 ,伴随着转化生长因子(TGF)-β1和 PDGFR-β表达水平降低。[5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[4]
  • Cell lines: 人类原代Schwann 和schwannoma细胞
  • Concentrations: 1 μM -10 μM
  • Incubation Time: 72小时
  • Method: 人类原代 Schwann和 schwannoma细胞接种在预包被的96孔板上。加入Nilotinib,40分钟后,使用100 ng/mL PDGF-DD刺激处理,细胞培养72小时(3 天)。因为Nilotinib的半衰期为18小时, 每天新鲜补充的浓度为最初加入浓度的一半。除了DAPI染色和测定全部细胞数外, 使用更敏感和准确的 BrdU渗透法测定增殖细胞。 使用倒置荧光显微镜和200 ×放大倍率。计算全部细胞数(DAPI)和分裂细胞数(BrdU阳性)。计数每孔中的所有细胞。每孔中不同批次细胞的全部细胞数不同。
动物实验:[4]
  • Animal Models: 雄性6周大的C57BL6小鼠
  • Dosages: 100 mg/kg
  • Administration: 口服饲喂

溶解度(25°C)

体外

体内

从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
4% DMSO+30% PEG 300+5% Tween 80+ddH2O

3mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 529.52
化学式

C28H22F3N7O

CAS号 641571-10-0
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05185947 Not yet recruiting Drug: Paclitaxel|Drug: Nilotinib Peritoneal Carcinomatosis|Peritoneal Neoplasms|Ovarian Cancer|Ovarian Neoplasms|Colorectal Cancer|Colorectal Neoplasms|Appendiceal Cancer|Appendiceal Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) August 2 2022 Phase 2
NCT04326933 Active not recruiting Drug: Tyrosine kinase Inhibitors (Imatinib & Nilotinib) Patients Diagnosed as Chronic Meyloid Leukemia Assiut University January 1 2020 --
NCT04002674 Recruiting Drug: Placebo oral capsule|Drug: Nilotinib Oral Capsule Dementia With Lewy Bodies Georgetown University|National Institutes of Health (NIH) July 1 2019 Phase 2
NCT03942094 Recruiting Drug: Nilotinib Chronic Myeloid Leukemia Chronic Phase|Nilotinib Shenzhen Second People''s Hospital|Zhongshan City People''s Hospital|The Affiliated Hospital of Guangdong Medical College|Huazhong University of Science and Technology Union Shenzhen Hospital|Dongguan People''s Hospital|Longgang District Central Hospital of Shenzhen June 1 2019 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-08-01)

技术支持

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操作手册

如果有其他问题,请给我们留言。

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常见问题及建议解决方法

问题 1:
I would like to use AMN-107 for in vivo studies in mice, can you give me some suggestions about the in vivo formulation?

回答:
For in vivo study, we recommend to use 4% DMSO+30% PEG 300+5% Tween 80+ddH2O up to 3mg/ml.

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