LDN-193189

For research use only. Not for use in humans.

目录号：S2618 别名： DM3189

CAS No. 1062368-24-4

LDN-193189 (DM3189)是一种选择性的BMP信号通路抑制剂，抑制BMP I型受体ALK2和ALK3的转录活性，在C2C12细胞中IC50分别为5 nM和30 nM，作用于BMP比作用于TGF-β选择性高200倍。

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2mg	RMB 898.78	现货
5mg	RMB 1402.75	现货
25mg	RMB 4664.07	现货
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客户使用Selleck生产的LDN-193189发表文献145篇：

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Nature, 2019, 573(7774):421-425

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Cell, 2019, 177(4):910-924

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Nat Methods, 2014, 11(8):855-60

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Gastroenterology, 2014, 147(1):196-208

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Acta Neuropathol, 2021, 141(2):257-279

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Nat Commun, 2021, 12(1):2695

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EMBO J, 2021, e103811

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EMBO Mol Med, 2021, e12632

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Cell Rep, 2021, 35(5):109069

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Mol Ther, 2021, 29(4):1639-1657

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Stem Cell Res, 2021, 53:102327

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FASEB J, 2021, 35(3):e21263

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J Cell Physiol, 2021, 10.1002/jcp.30254

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Int J Mol Sci, 2021, 22(8)3945

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Food Chem Toxicol, 2021, 152:112178

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Ann Transl Med, 2021, 9(7):557

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Neurochem Res, 2021, 10.1007/s11064-021-03276-3

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Stem Cell Res, 2021, 52:102240

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Nature, 2021, 10.1038/s41586-021-03273-0

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J Clin Invest, 2021, 146287

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J Clin Invest, 2020, 130(2):942-957

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Proc Natl Acad Sci U S A, 2020, 117(40):25092-25103

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Genes Dev, 2020, 10.1101/gad.332494.119

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Cell Rep, 2020, 30(3):771-782

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Glia, 2020, 68(3):589-599

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J Clin Endocrinol Metab, 2020, 105(1)

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Cells, 2020, 9(10)E2288

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FASEB J, 2020, 10.1096/fj.202001448R

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Sci Rep, 2020, 10(1):14474

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J Steroid Biochem Mol Biol, 2020, 199:105587

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J Biol Chem, 2020, 295(50):17114-17127

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J Biol Chem, 2020, jbc.RA120.015165

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Skelet Muscle, 2020, 2;10(1):13

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Biol Reprod, 2020, 15;102(4):795-805

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Biochem Biophys Res Commun, 2020, 524(2):360-365

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Biomed Res Int, 2020, 2020:7626215

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Mil Med Res, 2020, 7(1):42

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Neurosci Lett, 2020, 18;716:134681

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Exp Ther Med, 2020, 20(4):3001-3008

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J Biol Chem, 2020, jbc.RA120.13352

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Curr Protoc Stem Cell Biol, 2020, 55(1):e120

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Cell Death Dis, 2020, 11(3):172

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Heliyon, 2020, 12;6(4):e03743

PubMed: 32322728 ( click the link to review the publication )

J Bone Miner Res, 2020, 10.1002

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Commun Biol, 2020, 3(1):604

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Metabolites, 2020, 10(8):E302

PubMed: 32717953 ( click the link to review the publication )

Nat Commun, 2019, 10(1):928

PubMed: 30804331 ( click the link to review the publication )

Nat Commun, 2019, 10(1):2612

PubMed: 31197141 ( click the link to review the publication )

Nat Commun, 2019, 10(1):3933

PubMed: 31477693 ( click the link to review the publication )

Nat Commun, 2019, 10(1):4269

PubMed: 31537794 ( click the link to review the publication )

Autophagy, 2019, 15(4):631-651

PubMed: 30335591 ( click the link to review the publication )

Autophagy, 2019, 15(6):1051-1068

PubMed: 30669930 ( click the link to review the publication )

Biomaterials, 2019, 10.1016/j.biomaterials.2019.119602

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Thyroid, 2019, 29(11):1683-1703

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Stem Cell Res, 2019, 41:101615

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Stem Cell Res, 2019, 34:101368

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Stem Cell Res, 2019, 34:101349

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Stem Cell Reports, 2019, 13(2):338-351

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Stem Cell Res, 2019, 40:101563

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J Neurosci, 2019, 39(12):2184-2194

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Glia, 2019, 67(1):146-159

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J Clin Endocrinol Metab, 2019, 104(5):1667-1676

PubMed: 30541132 ( click the link to review the publication )

J Mol Cell Biol, 2019, 11(1):26-38

PubMed: 29771334 ( click the link to review the publication )
Mol Ther Methods Clin Dev, 2019, 13:414-430

PubMed: 31061832 ( click the link to review the publication )

J Cell Physiol, 2019, 10.1002/jcp.28247

PubMed: 30714152 ( click the link to review the publication )

Sci Rep, 2019, 9(1):1897

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Stem Cells Int, 2019, 2019:5026793

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Front Neurosci, 2019, 13:867

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Am J Transl Res, 2019, 11(6):3490-3504

PubMed: 31312361 ( click the link to review the publication )

Theriogenology, 2019, 135:204-212

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Methods Mol Biol, 2019, 2005:101-124

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Nat Metab, 2019, 1(2):222-235

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Nat Neurosci, 2019, 22(3):386-400

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Nat Cell Biol, 2018, 20(8):909-916

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ACS Appl Mater Interfaces, 2018, 10(35):29238-29250

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Cell Rep, 2018, 25(4):1081-1096.e6

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Nanoscale, 2018, 10(7):3556-3565

PubMed: 29410983 ( click the link to review the publication )

Stem Cell Reports, 2018, 11(3):635-650

PubMed: 30174316 ( click the link to review the publication )

Cell Death Dis, 2018, 9(9):924

PubMed: 30206204 ( click the link to review the publication )

Front Immunol, 2018, 9:647

PubMed: 29651293 ( click the link to review the publication )

Biochim Biophys Acta Mol Cell Res, 2018, 1865(9):1239-1249

PubMed: 29902488 ( click the link to review the publication )

Cell Discov, 2018, 4:49

PubMed: 30181900 ( click the link to review the publication )

J Cell Physiol, 2018, 233(9):7268-7278

PubMed: 29600572 ( click the link to review the publication )

Front Cell Neurosci, 2018, 12:348

PubMed: 30337858 ( click the link to review the publication )

Tissue Eng Part A, 2018, 24(5-6):502-515

PubMed: 28602124 ( click the link to review the publication )

Toxicol Mech Methods, 2018, 28(4):286-292

PubMed: 29161937 ( click the link to review the publication )

Mol Ther Nucleic Acids, 2018, 12:817-828

PubMed: 30153566 ( click the link to review the publication )
Nature, 2018, 563(7733):701-704

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Nat Commun, 2017, 8:14382

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Stem Cell Reports, 2017, 9(6):1885-1897

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Stem Cell Reports, 2017, 9(3):883-896

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Alzheimers Res Ther, 2017, 9(1):90

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Cell Chem Biol, 2017, 24(7):833-844

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Acta Neuropathol Commun, 2017, 5(1):77

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Oxid Med Cell Longev, 2017, 2017:7601592

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Stem Cells Transl Med, 2017, 6(9):1803-1814

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J Cell Physiol, 2017, 232(12):3762-3774

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Int J Mol Sci, 2017, 18(12)E2591

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Neurochem Int, 2017, 106:48-61

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Oncol Rep, 2017, 37(2):713-720

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PLoS One, 2017, 12(5):e0177188

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Mol Biosyst, 2017, 13(10):2116-2124

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Biol Trace Elem Res, 2017, 176(2):294-304

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Sci Rep, 2017, 7:40191

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Biofabrication, 2017, 9(2):025007

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Stem Cell Reports, 2017, 8(2):264-277

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Cell, 2017, 168(3):473-486

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Oncotarget, 2017, 8(35):58625-58641

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Reproduction, 2017, 154(6):745-753

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Nat Commun, 2016, 7:13516

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Mol Cancer, 2016, 15:27

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Stem Cell Res, 2016, 17(3):576-579

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Stem Cell Res, 2016, 17(3):600-602

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Oncoimmunology, 2016,

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J Dent Res, 2016, 95(3):292-301

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Sci Rep, 2016, 6:28572

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Oncol Rep, 2016, 35(2):939-47

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Differentiation, 2016, 10.1016/j.diff.2016.06.002

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Stem Cells, 2015, 33(5):1447-55

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产品安全说明书

TGF-beta/Smad抑制剂选择性比较

生物活性

产品描述

靶点

ALK2 ^[1] (C2C12 cells)	ALK3 ^[1] (C2C12 cells)
5 nM	30 nM

体外研究

LDN193189有效抑制BMP4介导的Smad1，Smad5和Smad8活化, IC 50为5 nM，并有效地抑制BMP的I型受体ALK2和ALK3的转录活性，IC 50分别为5 nM和30 nM。此外，LDN193189还抑制组成型活性ALK2^R206H or ALK2^Q207D突变蛋白诱导的转录活性。^[1] 最近的一项研究表明在动脉粥样硬化形成的人主动脉内皮细胞中，LDN-193189阻止氧化低密度脂蛋诱导的活性氧生成。^[4]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
C2C12	MUTLbY5ie2ViQYPzZZk>				M1y3eolvcGmkaYTzJJRp\SCtaX7hd4Uh[WO2aY\peJkhd2ZiQVzLOEBidmRiQXP0VmlKSSC5aYToJGlEPTEEoI\hcJVmeyCxZjCxNFEh[W6mIEKxNEBvdSxicnXzdIVkfGm4ZXz5	Mn;MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV\|NkizNlIoRjJ3M{[4N\|IzRC:jPh?=
EOC216	NF7HWnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mnr6NE4yNTFyIN88US=>	M1rEXlIuOTBiZB?=	MmLhSG1UVw>?	MXfpcoR2[2ViY3XscEBl\WG2aDDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?=	M3jqZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MkK3PFk{Lz5{NUKyO\|g6OzxxYU6=
OVAC429	NUK5ZWdFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnnXNk82KM7:TR?=	MXG0PEBp	MoDkSG1UVw>?	M2XycIRm[3KnYYPld{B1cGVicHXyZ4VvfGGpZTDv[kBk\WyuczDpckBUKHCqYYO=	NEfvZYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKyO\|g6Oyd-MkWyNlc5QTN:L3G+
SKOV3	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWCyM\|Uh\|ryP	MUC0PEBp	M3ewOmROW09?	M3G1OYRm[3KnYYPld{B1cGVicHXyZ4VvfGGpZTDv[kBk\WyuczDpckBUKHCqYYO=	MlHDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{Mke4PVMoRjJ3MkK3PFk{RC:jPh?=
OVCA429	M3L5Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4m4VVIwPSEQvF2=	M2exdVQ5KGh?	NI\UVWhFVVOR	Mmrn[IVkemWjc3XzJJRp\SCyZYLj[Y51[WenIH;mJINmdGy\|IHnuJHMheGijcx?=	NEC0[Y89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKyO\|g6Oyd-MkWyNlc5QTN:L3G+
EOC219	MoLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVGyM\|Uh\|ryP	MUW0PEBp	NHnMfXhFVVOR	Mojk[IVkemWjc3XzJJRp\SCyZYLj[Y51[WenIH;mJINmdGy\|IHnuJHMheGijcx?=	NXKz[Vk6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyNlc5QTNpPkK1NlI4QDl\|PD;hQi=>
A549	Mnj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4WwRVAvPS1zNjFOwG0>		NFO5NFVFVVOR	MYnpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=>	MlzIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5N{iwNVEoRjJ2N{e4NFEyRC:jPh?=
BEAS-2B	NH7icGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlHnNE42NTF4IN88US=>		NIn3U5NFVVOR	M3PXSolvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz	M4nH[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{e4NFEyLz5{NEe3PFAyOTxxYU6=
hBMSCs	MYnGeY5kfGmxbjDBd5NigQ>?	MUKwMlLDqM7:TR?=	NUfaXZhqPyCm		NVXQWZZz[WKxbHnzbIV{KHSqZTDzbYxq[mmwaX6tdJJwdW:2ZXSgRWxRKGGldHn2bZR6yqCyYYL0cJk>	MkfaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyN{[xPFcoRjJ2MEe2NVg4RC:jPh?=
PANC-1	MkjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NE\rcXk2NTVyMDDuUS=>	M{fnXFQ5KGh?		MnrMbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI>	MmqwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7Nkm3NlkoRjJ\|OU[5O\|I6RC:jPh?=
MIA PaCa-2	MoOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoXSOU02ODBibl2=	MWi0PEBp		M1vvN4lvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4OUeyPUc,OjN7Nkm3Nlk9N2F-
Bx-PC3	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUS1MVUxOCCwTR?=	M{L0blQ5KGh?		MXLpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=>	NFK4cmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2PVczQSd-MkO5Olk4Ojl:L3G+
PC3	MXzGeY5kfGmxbjDBd5NigQ>?	NWrQUmZpPTByIH7N	NFjz[mszKGh?		M{TjZ5JmeHKnc4Pld{Bi[3SrdnH0bY9vKG:oIGPtZYQyNzVxODDhcoQhWC2VbXHkN{Bt\X[nbIO=	NXnOPVJzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0OVI5QDNpPkKyOFUzQDh\|PD;hQi=>
LNCaP	MVPGeY5kfGmxbjDBd5NigQ>?	MnfzNQKBmzVyMDDuUS=>	M{DwWFIhcA>?		MmT6doV3\XK\|ZYOgdoFx[W27Y3nuMYlv\HWlZXSgZ4VtdCCmZXH0bC=>	M2S4NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEWyPFg{Lz5{MkS1Nlg5OzxxYU6=
EOC	M2LaR2Z2dmO2aX;uJGF{e2G7	NV;Bd5dPOTBvMUCwNEBvVQ>?	MkjRO\|IhcA>?		M1m4UJJm\HWlZYOgeIhmKHCqb4PwbI9zgWyjdHXkJGJOWCCULWPtZYQyNzVxONMg	NEPyN3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK0PVQyPSd-MkKyOFk1OTV:L3G+
HaCaT	MWfGeY5kfGmxbjDBd5NigQ>?	MmPoNE4xODFvMUCg{txO	M{jDTlIhcA>?		MXLpcohq[mm2czDCUXAzNWmwZIXj[YQheGixc4Doc5J6dGG2aX;uJI9nKFOvYXSxM\|UwQCC5aYToJIFvKEmFNUFCpI9nKH5yLkCwOeKh\|ryP	NGPT[\|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUe0NFk3Pid-MkG3OFA6PjZ:L3G+
HaCaT	MnLQSpVv[3Srb36gRZN{[Xl?	M3mxdVAvODBzLUGwJO69VQ>?	MnHFNkBp		MUTpcohq[mm2czD0bIUh[WKrbHn0fUBw\iCDTFuyJJRwKHCqb4PwbI9zgWyjdHWgS3NVNVOvYXSxxsB4cXSqIHHuJGlEPTEEoH;mJFQ2yqCwTR?=	M{L5XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{SwPVY3Lz5{MUe0NFk3PjxxYU6=
HaCaT	M{nsZWZ2dmO2aX;uJGF{e2G7	MXmwMlAxOS1zMDFOwG0>	MWiyJIg>		NVfPXmtlcW6qaXLpeJMhfGinIHHibYxqfHlib3[gRWxMOyC2bzDwbI9{eGixconsZZRmKFOvYXSxxsB4cXSqIHHuJGlEPTEEoH;mJFExOCCwTR?=	Mm\xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5NEC5OlYoRjJzN{SwPVY3RC:jPh?=
HaCaT	M{PXWWZ2dmO2aX;uJGF{e2G7	NWiwSpZ7OC5yMEGtNVAh\|ryP	MYOyJIg>		MYLpcohq[mm2czDBUGs1KGGwZDDBUGs2KHerdHigTWM2OMLidnHseYV{KG:oIECuN:Kh\|ryPIHHu[EAxNjYEoN88UUBz\XOyZXP0bZZmdHl?	NULpN3hURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3OFA6PjZpPkKxO\|QxQTZ4PD;hQi=>
C2C12	M3vCOmZ2dmO2aX;uJIF{e2G7		MXKzNEBucW6\|		NYLUeJJYUW6qaXLpeIlwdiCxZjDCUXA3NWmwZIXj[YQhSUyNMjD0doFve2O{aYD0bY9v[WxiYXP0bZZqfHliaX6gcY92e2ViQ{LDNVIh[2WubIOg[ZhxemW\|c3nu[{BDWkVvTIXjJIFnfGW{IEOwJI1qdnNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwJF0hOC5yMUSg{txONg>?	Mn31QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{Mke5OFYoRjNyMkK3PVQ3RC:jPh?=
BT-12	NULjRmk5eUiWUzDhd5NigQ>?				NHvHelNyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiQmStNVIh[2WubIO=	M1nVSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
fibroblast cell	M{LzVZFJXFNiYYPzZZk>				M{P2d5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiClb370do9tKEiqIIfpcIQhfHmyZTDmbYJzd2KuYYP0JINmdGy\|	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
Rh30	MVjxTHRUKGG\|c3H5				M13G[ZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCUaEOwJINmdGy\|	NITibms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
KB-3-1	NFfhS\|hHfW6ldHnvckBie3OjeR?=				MlmwVE1odHmlb4Dyc5RmcW5ic4Xid5Rz[XSnczDp[IVvfGmoaXXkJIlvKEuELUOtNUBi\GWwb3PhdoNqdm:vYTDj[YxtKGyrbnWsJJFJXFNidHjldoFx\XW2aXOgcIljemG{eTDzZ5Jm\W5?	M4\VNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUG1Nlg1Lz5\|MUWxOVI5PDxxYU6=
C2C12	NVS2V3NETnWwY4Tpc44h[XO\|YYm=	NWP0VWFJOC5zIIXN			NI\tc2hKdmirYnn0bY9vKG:oIFHMT\|UhcW5ibX;1d4UhSzKFMUKgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hXEeIYnX0ZVEucW6mdXPl[EBUdWGmMT:1JJBpd3OyaH;yfYxifGmxbjDheEAxNjFidV2gZpkhX2W\|dHXyckBjdG:2IH3leIhw\A>?	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDFyM{CyOUc,OjhzMEOwNlU9N2F-

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	pSMAD1 / pSMAD5 / pSMAD8 / SMAD1 / SMAD5 / SMAD8 / ID1 / SMAD4 / PARP / Cleaved PARP; PubMed: 31098401 Commun Biol In vitro molecular pharmacology of LDN-193189 and LDN-214117. Western blot analysis of time- and concentration-dependent effects on downstream signalling in response to a LDN-193189 and b LDN-214117 in DIPG cells. Increasing concentrations (0–10 µM) at 4 and 8 h are shown for SU-DIPG-VI, HSJD-DIPG-IV and HSJD-DIPG-007. GAPDH is the loading control.	31098401
Immunofluorescence	Tbx18 / Hcn4; PubMed: 30906456 Exp Ther Med Representative immunofluorescence microscopy images of epicardial progenitor cells from the four groups with staining for Hcn4 (red). The nuclei were counterstained with DAPI (blue) and the YFP expressed by the cells is apparent (scale bar, 50 µm). (Tbx18 was conjugated to YFP).	30906456
Growth inhibition assay	Cell viability; PubMed: 31098401 Commun Biol Screening of ALK2 inhibitors in vitro. Concentration-response curves for eight ALK2 inhibitors tested against three ACVR1 mutant cell cultures (HSJD-DIPG-007 (R206H), SU-DIPG-IV (G328V), HSJD-DIPG-018 (R258G), purple) and two wild-type cultures (SU-DIPG-VI, QCTB-R059, grey). a Pyrazolo[1,5-a]pyrimidines—dorsomorphin, LDN-193189, DMH1, LDN-212854. b Pyridines—K02288, LDN-214117, LDN-213844, LDN-213819. Concentration of compound is plotted on a log scale (x-axis) against cell viability (y-axis). Mean plus standard deviation are plotted from at least n = 3 experiments.	31098401

体内研究

在利用Ad.Cre条件性caALK2转基因小鼠中，与对7日龄（P7），LDN-193189（3 mg/kg,腹腔注射）导致邻近的左胫骨和腓骨在P13出现轻度钙化，并防止在P15出现放射线病变而不会造成体重减轻或生长迟缓，自发性骨折，骨质密度下降或行为异常。^[1] LDN193189通过抑制骨形态发生蛋白（BMP）6诱导的信号转导途径而斑马鱼胚胎背部化，而对血管发育无影响。^[2] 在含PCa-118b瘤小鼠中，LDN-193189削弱肿瘤生长并降低了肿瘤中的骨形成。^[3] 在低密度脂蛋白受体缺陷（LDLR-/-）小鼠中，LDN-193189有效地抑制动脉粥样硬化的发展。此外，LDN-193189也表现出对相关的血管炎，成骨活性和钙化的抑制作用。^[4]

动物实验：^[1]	- 合并 Animal Models: Ad.Cre在第7天注射到条件caALK2–转基因鼠和正常鼠中。 Dosages: 小于等于3 mg/kg Administration: 腹腔注射 (Only for Reference)

参考文献

[4] Derwall M, et al. Arterioscler Thromb Vasc Biol, 2012, 32(3), 613-622.

- 合并

溶解度 (25°C)

体外	DMSO	Insoluble
	Water	Insoluble
	Ethanol	Insoluble

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download LDN-193189 SDF

分子量	406.48
化学式	C₂₅H₂₂N₆
CAS号	1062368-24-4
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	DM3189

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

TGF-beta/Smad Signaling Pathway Map

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选择性强的TGF-β Receptor抑制剂

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活性最高的TGF-β Receptor抑制剂

SB525334 : TGFβ receptor I (ALK5), IC50=14.3 nM.
用于临床的TGF-β Receptor抑制剂

LY2157299 : Phase II for Glioblastoma and Hepatocellular Carcinoma.
最新的TGF-β Receptor抑制剂

K02288 ^New : Potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.

研究领域

产品类型

定制您的化合物库

LDN-193189

客户使用Selleck生产的LDN-193189发表文献145篇：

产品安全说明书

TGF-beta/Smad抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download LDN-193189 SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

技术支持

TGF-beta/Smad Signaling Pathway Map

TGF-beta/Smad Inhibitors with Unique Features

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