LDN-193189

For research use only. Not for use in humans.

目录号：S2618 别名： DM3189

CAS No. 1062368-24-4

LDN-193189 (DM3189)是一种选择性 BMP 信号抑制剂，抑制 ALK1, ALK2, ALK3和 ALK6，在激酶测定中的 IC50 分别为 0.8 nM、0.8 nM、5.3 nM 和 16.7 nM。LDN-193189 抑制BMP I型受体ALK2和ALK3的转录活性，在C2C12细胞中IC50分别为5 nM和30 nM，作用于BMP比作用于TGF-β选择性高200倍。如需进行动物实验，建议选择可水溶产品 S7507 LDN-193189 2HCl。

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2mg	RMB 898.78	现货
5mg	RMB 1402.75	现货
25mg	RMB 4664.07	现货
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客户使用Selleck生产的LDN-193189发表文献158篇：

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产品安全说明书

TGF-beta/Smad抑制剂选择性比较

生物活性

产品描述

靶点

ALK1 ^[5] (Cell-free assay)	ALK2 ^[5] (Cell-free assay)	ALK3 ^[5] (Cell-free assay)	ALK6 ^[5] (Cell-free assay)
0.8 nM	0.8 nM	5.3 nM	16.7 nM

体外研究

LDN193189有效抑制BMP4介导的Smad1，Smad5和Smad8活化, IC 50为5 nM，并有效地抑制BMP的I型受体ALK2和ALK3的转录活性，IC 50分别为5 nM和30 nM。此外，LDN193189还抑制组成型活性ALK2^R206H or ALK2^Q207D突变蛋白诱导的转录活性。^[1] 最近的一项研究表明在动脉粥样硬化形成的人主动脉内皮细胞中，LDN-193189阻止氧化低密度脂蛋诱导的活性氧生成。^[4]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
C2C12	NYqzPVJvU2mwYYPlJGF{e2G7				NWfpc2RCcW6qaXLpeJMhfGinIHvpcoF{\SCjY4Tpeol1gSCxZjDBUGs1KGGwZDDBZ5RTUUmDIIfpeIghUUN3MNMgeoFtfWW\|IH;mJFExOSCjbnSgNlExKG6vLDDy[ZNx\WO2aY\lcJk>	NFTTeVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUO2PFMzOid-MkWzOlg{OjJ:L3G+
EOC216	MojvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWmwMlEuOTBizszN	MWSyMVExKGR?	MU\EUXNQ	M4TrZ4lv\HWlZTDj[YxtKGSnYYToJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy	MkTsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{Mke4PVMoRjJ3MkK3PFk{RC:jPh?=
OVAC429	Mnv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHnScJYzNzVizszN	NGfsVVM1QCCq	M{HPWmROW09?	MnLq[IVkemWjc3XzJJRp\SCyZYLj[Y51[WenIH;mJINmdGy\|IHnuJHMheGijcx?=	M2jyclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MkK3PFk{Lz5{NUKyO\|g6OzxxYU6=
SKOV3	MmDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXWyM\|Uh\|ryP	M1e4XlQ5KGh?	NWDrb2g{TE2VTx?=	NYfwcZJy\GWlcnXhd4V{KHSqZTDw[ZJk\W62YXflJI9nKGOnbHzzJIlvKFNicHjhdy=>	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ{N{i5N{c,OjV{Mke4PVM9N2F-
OVCA429	NUTvSZBET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXrNZnRNOi93IN88US=>	NE[xbXI1QCCq	MVfEUXNQ	Ml;t[IVkemWjc3XzJJRp\SCyZYLj[Y51[WenIH;mJINmdGy\|IHnuJHMheGijcx?=	NYPVUFFTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyNlc5QTNpPkK1NlI4QDl\|PD;hQi=>
EOC219	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXXGSG97Oi93IN88US=>	MoL6OFghcA>?	NET1eYNFVVOR	MVPk[YNz\WG\|ZYOgeIhmKHCncnPlcpRi\2Vib3[gZ4VtdHNiaX6gV{BxcGG\|	MknmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{Mke4PVMoRjJ3MkK3PFk{RC:jPh?=
A549	NEnCbolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3PBVlAvPS1zNjFOwG0>		MYjEUXNQ	MmjlbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI>	NVr2WHhnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3O\|gxOTFpPkK0O\|c5ODFzPD;hQi=>
BEAS-2B	NFXNbYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYWwMlUuOTZizszN		NE[wWXJFVVOR	NFLD[pRqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>?	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd5OECxNUc,OjR5N{iwNVE9N2F-
hBMSCs	NYH4c\|JzTnWwY4Tpc44hSXO\|YYm=	MW[wMlLDqM7:TR?=	NGrP[FI4KGR?		MXPhZo9tcXOqZYOgeIhmKHOrbHnibY5qdi2ycn;tc5Rm\CCDTGCgZYN1cX[rdIpCpJBienSueR?=	NEC2XZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC3OlE5Pyd-MkSwO\|YyQDd:L3G+
PANC-1	M1nSfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NW\0VJVQPS13MECgcm0>	NGryTJA1QCCq		MkfPbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI>	NH7QW289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2PVczQSd-MkO5Olk4Ojl:L3G+
MIA PaCa-2	MkLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M125e\|UuPTByIH7N	MW[0PEBp		NYHoWms6cW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ?	MnXlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7Nkm3NlkoRjJ\|OU[5O\|I6RC:jPh?=
Bx-PC3	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYG1MVUxOCCwTR?=	NUHiemQ6PDhiaB?=		NIexNYRqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>?	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4OUeyPUc,OjN7Nkm3Nlk9N2F-
PC3	MlG3SpVv[3Srb36gRZN{[Xl?	MlzKOVAxKG6P	NF3SdYIzKGh?		M1fMeZJmeHKnc4Pld{Bi[3SrdnH0bY9vKG:oIGPtZYQyNzVxODDhcoQhWC2VbXHkN{Bt\X[nbIO=	NH7CS5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS1Nlg5Oyd-MkK0OVI5QDN:L3G+
LNCaP	MYfGeY5kfGmxbjDBd5NigQ>?	MnvmNQKBmzVyMDDuUS=>	M3i2PVIhcA>?		MkDhdoV3\XK\|ZYOgdoFx[W27Y3nuMYlv\HWlZXSgZ4VtdCCmZXH0bC=>	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR3Mki4N{c,OjJ2NUK4PFM9N2F-
EOC	NXy3XIQ3TnWwY4Tpc44hSXO\|YYm=	NETBc2cyOC1zMECwJI5O	MnzFO\|IhcA>?		NXTme5ZbemWmdXPld{B1cGVicHjvd5Bpd3K7bHH0[YQhSk2SIGKtV41i\DFxNT:4xsA>	Mor1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{NEm0NVUoRjJ{MkS5OFE2RC:jPh?=
HaCaT	M2nh[2Z2dmO2aX;uJGF{e2G7	NELKS5gxNjByMT2xNEDPxE1?	M1i5PVIhcA>?		NIrzXGRqdmirYnn0d{BDVVB{LXnu[JVk\WRicHjvd5Bpd3K7bHH0bY9vKG:oIGPtZYQyNzVxODD3bZRpKGGwIFnDOVDDqG:oII6wMlAxPcLizszN	MkizQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5NEC5OlYoRjJzN{SwPVY3RC:jPh?=
HaCaT	MljSSpVv[3Srb36gRZN{[Xl?	NI[3UoQxNjByMT2xNEDPxE1?	NYT1[\|dQOiCq		NUO4XpRmcW6qaXLpeJMhfGinIHHibYxqfHlib3[gRWxMOiC2bzDwbI9{eGixconsZZRmKEeVVD3TcYFlOcLid3n0bEBidiCLQ{WwxsBw\iB2NdMgcm0>	Mn7nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5NEC5OlYoRjJzN{SwPVY3RC:jPh?=
HaCaT	NEH1b4tHfW6ldHnvckBCe3OjeR?=	Mn3oNE4xODFvMUCg{txO	MV2yJIg>		MXLpcohq[mm2czD0bIUh[WKrbHn0fUBw\iCDTFuzJJRwKHCqb4PwbI9zgWyjdHWgV41i\DIEoIfpeIgh[W5iSVO1NOKhd2ZiMUCwJI5O	M1jwblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{SwPVY3Lz5{MUe0NFk3PjxxYU6=
HaCaT	NEK2VWVHfW6ldHnvckBCe3OjeR?=	Mmj4NE4xODFvMUCg{txO	NEXCVYczKGh?		MVLpcohq[mm2czDBUGs1KGGwZDDBUGs2KHerdHigTWM2OMLidnHseYV{KG:oIECuN:Kh\|ryPIHHu[EAxNjYEoN88UUBz\XOyZXP0bZZmdHl?	NWrtVHl{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3OFA6PjZpPkKxO\|QxQTZ4PD;hQi=>
C2C12	NHLHb3hHfW6ldHnvckBie3OjeR?=		MoTsN\|AhdWmwcx?=		NXzMdXpkUW6qaXLpeIlwdiCxZjDCUXA3NWmwZIXj[YQhSUyNMjD0doFve2O{aYD0bY9v[WxiYXP0bZZqfHliaX6gcY92e2ViQ{LDNVIh[2WubIOg[ZhxemW\|c3nu[{BDWkVvTIXjJIFnfGW{IEOwJI1qdnNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwJF0hOC5yMUSg{txONg>?	M4noZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkK3PVQ3Lz5\|MEKyO\|k1PjxxYU6=
BT-12	M1zKeZFJXFNiYYPzZZk>				NEjr[IpyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiQmStNVIh[2WubIO=	M{XK[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
fibroblast cell	MkfRdWhVWyCjc4PhfS=>				MVfxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5Ih[2:wdILvcEBJcCC5aXzkJJR6eGViZnnido9jdGG\|dDDj[Yxtew>?	NXnrdINCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
Rh30	M2LCUZFJXFNiYYPzZZk>				M3PQdJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCUaEOwJINmdGy\|	MlexQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
KB-3-1	M{XBV2Z2dmO2aX;uJIF{e2G7				MlrOVE1odHmlb4Dyc5RmcW5ic4Xid5Rz[XSnczDp[IVvfGmoaXXkJIlvKEuELUOtNUBi\GWwb3PhdoNqdm:vYTDj[YxtKGyrbnWsJJFJXFNidHjldoFx\XW2aXOgcIljemG{eTDzZ5Jm\W5?	MljZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF3MUWyPFQoRjNzNUG1Nlg1RC:jPh?=
C2C12	NFPL[o1HfW6ldHnvckBie3OjeR?=	MVOwMlEhfU1?			NFTZenFKdmirYnn0bY9vKG:oIFHMT\|UhcW5ibX;1d4UhSzKFMUKgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hXEeIYnX0ZVEucW6mdXPl[EBUdWGmMT:1JJBpd3OyaH;yfYxifGmxbjDheEAxNjFidV2gZpkhX2W\|dHXyckBjdG:2IH3leIhw\A>?	M2PhO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUCzNFI2Lz5{OEGwN\|AzPTxxYU6=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	pSMAD1 / pSMAD5 / pSMAD8 / SMAD1 / SMAD5 / SMAD8 / ID1 / SMAD4 / PARP / Cleaved PARP; PubMed: 31098401 Commun Biol In vitro molecular pharmacology of LDN-193189 and LDN-214117. Western blot analysis of time- and concentration-dependent effects on downstream signalling in response to a LDN-193189 and b LDN-214117 in DIPG cells. Increasing concentrations (0–10 µM) at 4 and 8 h are shown for SU-DIPG-VI, HSJD-DIPG-IV and HSJD-DIPG-007. GAPDH is the loading control.	31098401
Immunofluorescence	Tbx18 / Hcn4; PubMed: 30906456 Exp Ther Med Representative immunofluorescence microscopy images of epicardial progenitor cells from the four groups with staining for Hcn4 (red). The nuclei were counterstained with DAPI (blue) and the YFP expressed by the cells is apparent (scale bar, 50 µm). (Tbx18 was conjugated to YFP).	30906456
Growth inhibition assay	Cell viability; PubMed: 31098401 Commun Biol Screening of ALK2 inhibitors in vitro. Concentration-response curves for eight ALK2 inhibitors tested against three ACVR1 mutant cell cultures (HSJD-DIPG-007 (R206H), SU-DIPG-IV (G328V), HSJD-DIPG-018 (R258G), purple) and two wild-type cultures (SU-DIPG-VI, QCTB-R059, grey). a Pyrazolo[1,5-a]pyrimidines—dorsomorphin, LDN-193189, DMH1, LDN-212854. b Pyridines—K02288, LDN-214117, LDN-213844, LDN-213819. Concentration of compound is plotted on a log scale (x-axis) against cell viability (y-axis). Mean plus standard deviation are plotted from at least n = 3 experiments.	31098401

体内研究

在利用Ad.Cre条件性caALK2转基因小鼠中，与对7日龄（P7），LDN-193189（3 mg/kg,腹腔注射）导致邻近的左胫骨和腓骨在P13出现轻度钙化，并防止在P15出现放射线病变而不会造成体重减轻或生长迟缓，自发性骨折，骨质密度下降或行为异常。^[1] LDN193189通过抑制骨形态发生蛋白（BMP）6诱导的信号转导途径而斑马鱼胚胎背部化，而对血管发育无影响。^[2] 在含PCa-118b瘤小鼠中，LDN-193189削弱肿瘤生长并降低了肿瘤中的骨形成。^[3] 在低密度脂蛋白受体缺陷（LDLR-/-）小鼠中，LDN-193189有效地抑制动脉粥样硬化的发展。此外，LDN-193189也表现出对相关的血管炎，成骨活性和钙化的抑制作用。^[4]

动物实验： ^[1]	- 合并 Animal Models: Ad.Cre在第7天注射到条件caALK2–转基因鼠和正常鼠中。 Dosages: 小于等于3 mg/kg Administration: 腹腔注射 (Only for Reference)

参考文献

- 合并

溶解度 (25°C)

体外	DMSO	Insoluble
	Water	Insoluble
	Ethanol	Insoluble

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download LDN-193189 SDF

分子量	406.48
化学式	C₂₅H₂₂N₆
CAS号	1062368-24-4
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	DM3189

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

TGF-beta/Smad Signaling Pathway Map

TGF-beta/Smad Inhibitors with Unique Features

活性最高的TGF-β Receptor抑制剂

SB525334 : TGFβ receptor I (ALK5), IC50=14.3 nM.
用于临床的TGF-β Receptor抑制剂

LY2157299 : Phase II for Glioblastoma and Hepatocellular Carcinoma.
最新的TGF-β Receptor抑制剂

K02288 ^New : Potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.

研究领域

产品类型

定制您的化合物库

LDN-193189

客户使用Selleck生产的LDN-193189发表文献158篇：

产品安全说明书

TGF-beta/Smad抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download LDN-193189 SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

技术支持

TGF-beta/Smad Signaling Pathway Map

TGF-beta/Smad Inhibitors with Unique Features

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