Verapamil (CP-16533-1) HCl

For research use only. Not for use in humans.

目录号:S4202 中文名称:盐酸维拉帕米

Verapamil (CP-16533-1) HCl Chemical Structure

CAS No. 152-11-4

Verapamil HCl (CP-16533-1)是L-型钙通道抑制剂,是第四类抗心律失常的药剂。Verapamil 可抑制 permeability-glycoprotein (P-gp)CYP3A4

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客户使用Selleck生产的Verapamil (CP-16533-1) HCl发表文献18篇:

客户使用该产品的3个实验数据:

  • The proportion of SP cells in HepG2 and HCCLM3 cell lines were 0.16% and 32.2%, which reduced to 0% and 0.28% in the presence of verapamil.

    Front Pharmacol, 2018, 9:1298. Verapamil (CP-16533-1) HCl purchased from Selleck.

  • f, Cells were pretreated with or without 5 μM verapamil and then treated with the indicated concentrations of 17-DMAG for 6 h. The proteins involved in ALK-related signaling were detected by western blot analysis.

    BMC Cancer, 2015, 15:553.. Verapamil (CP-16533-1) HCl purchased from Selleck.

  • J45.01 cells were suspended in a growth medium containing 0.1 μM 5-CFDA and kept on ice for 20 min to allow its uptake. The effects of verapamil (MDR1 inhibitor) and MK571 (MRP1 inhibitor) on the efflux of 5-CF at 37°C was determined by flow cytometry (B).

    Exp Hematol, 2017, 2.436. Verapamil (CP-16533-1) HCl purchased from Selleck.

产品安全说明书

Calcium Channel抑制剂选择性比较

生物活性

产品描述 Verapamil HCl (CP-16533-1)是L-型钙通道抑制剂,是第四类抗心律失常的药剂。Verapamil 可抑制 permeability-glycoprotein (P-gp)CYP3A4
靶点
Calcium channel [2]
体外研究

重组CES2的水解酶活性基本上被diltiazem和verapamil抑制(Ki分别为0.25 ± 0.02、3.84 ± 0.99μM)。

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HCT116/VM46 cell M4q2TGZ2dmO2aX;uJIF{e2G7 MnnzNUDPxE1? M4HMV2Vn\mWldDDvckB3cW6kbHHzeIlv\SCLQ{WwJIFo[Wmwc4SgUWRTKGi3bXHuJINiemOrbn;tZUBJS1RzMU[vWm01PiClZXzsJIxqdmViYYSgZUBld3OnIH;mJFEhfU1iY3;uZ4VvfHKjdHnvckwhUUN3ME2wMlAxPCEQvF2= NXnqVYR1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK3Nlk3PjNpPkGyO|I6PjZ|PD;hQi=>
human MCF7/ADR cells M2DvZWZ2dmO2aX;uJIF{e2G7 MkjBNVAh|ryP M1TEOVQ5KGh? NHHPcJRKdmirYnn0bY9vKG:oIGCt[5AhcW5iaIXtZY4hVUOINz;BSHIh[2WubIOgZZN{\XO|ZXSgZZMhemW4ZYLzZYwhd2ZibYXseIllenWpIILld4l{fGGwY3WgZZQhOTBidV2gZpkhdWWjc4XybY5oKEWFNUCg[o9zKGGmcnnhcZlkcW5vaX7keYNm\CCleYTveI95cWOrdImgZYZ1\XJiNEigbJJ{KGK7IGPSRkBkd2yxcnnt[ZRzcWNiYYPzZZktKEWFNUC9OE45QSEQvF2= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh3NkW0OUc,OjV6NU[1OFU9N2F-
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MDA435/LCC6 MDR1 MnfTSpVv[3Srb36gZZN{[Xl? NYDvOXdiXFChVGLBUnNRV1KWRWK6JJJmfmW{c3HsJI9nKF[rbnLsZZN1cW6nIHHjZ5VufWyjdHnvckApXmmwYnzhd5RqdmV8IECuNFA2KHWPKTDpckBOTEF2M{WvUGNEPiCPRGKxJINmdGy|LDDFR|UxRTNwMd88US=> M4nuR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzN{i0NVQ{Lz5zMUe4OFE1OzxxYU6=
MDA-435/LCC6 MVnGeY5kfGmxbjDhd5NigQ>? Mnv2SYZn\WO2IH;uJJJmfmW{c3HsJI9nKESRWDDhZ4N2dXWuYYTpc44hcW5iTVTBMVQ{PS:OQ1O2JEhR\3BvbnXnZZRqfmVrIHPlcIx{NixiRVO1NF01NjIQvF2= NUPlb3VmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG3PFQyPDNpPkGxO|g1OTR|PD;hQi=>
BTI-TN5B1-4 NGjkXFVHfW6ldHnvckBie3OjeR?= M1fXcXRRZ1SUQV7TVG9TXEWUOjDBWHAhcHmmcn;sfZNqeyCrbjDt[Y1jemGwZTDmdoFkfGmxbjDmdo9uKEirZ3igSol3\SBqQmTJMXRPPUJzLUSpJINmdGy|LDDLcV01NjB4zszN MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTd6NU[4OEc,OTF5OEW2PFQ9N2F-
MDCK NWPBR4lWTnWwY4Tpc44h[XO|YYm= NVnSdHY4XFChVGLBUnNRV1KWRWK6JIlvcGmkaYTpc44hd2ZiRHnnc5hqdiC2cnHud4VxcXSqZXzpZYwhfHKjboPwc5J1KCikYYPhcEB1dyCjcHnjZYwqKGmwIF3EVlEu\XiycnXzd4lv\yCPRFPLJINmdGy|LDDLbV0yPS5zzszN M4XncFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{MUO0PVQ2Lz5zMkGzOFk1PTxxYU6=
human embryonic kidney cells MVPGeY5kfGmxbjDhd5NigQ>? NFLNe|FMMyClaHHucoVtKGKub3PrbY5oKGGldHn2bZR6KGmwIHj1cYFvKGWvYoL5c45q[yCtaXTu[Zkh[2WubIOg[ZhxemW|c3nu[{BJTVKJIFv2NVEvOSxiSVO1NF0xNjF2M988US=> MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjF7MEOwPEc,OTJzOUCzNFg9N2F-
HCT15/CL02 NGfUXJJHfW6ldHnvckBie3OjeR?= NWr0VGU5XFChVGLBUnNRV1KWRWK6JIRzfWdicnXzbZN1[W6lZTCodIFkdGm2YYjlcEkhcW5iSFPUNVUwS0xyMjDj[YxteyxiSVO1NF0zNjJzzszN NGjVcWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkW2PVMxPSd-MUK1Olk{ODV:L3G+
MES-SA/DX5 MkHBSpVv[3Srb36gZZN{[Xl? NI\nPWhVWF:WUlHOV3BQWlSHUkqg[JJ2\yC{ZYPpd5RidmOnIDjwZYNtcXSjeHXsLUBqdiCPRWOtV2EwTFh3IHPlcIx{NCCLQ{WwQVQvPzkQvF2= MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjV4OUOwOUc,OTJ3NkmzNFU9N2F-
Caco-2 Mo[2SpVv[3Srb36gZZN{[Xl? MXHUVH9VWkGQU2DPVnRGWjpidILhcpNmeGm2aHXsbYFtKHS{YX7zdI9zfCCxZjDkbYdwgGmwIDjiZZNidCC2bzDhdIlk[WxrIHnuJGNi[29vMjDj[YxteyxiS3m9NE45QM7:TR?= M4jNWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NkO2NVU{Lz5zMk[zOlE2OzxxYU6=
L-MDR1 M4nmdGZ2dmO2aX;uJIF{e2G7 MYDUVH9VWkGQU2DPVnRGWjpiY3XscEBi[2O3bYXsZZRqd25ib3[gZ4Ft[2WrbjDpckBNNU2GUkGgZ4VtdHNuIFnDOVA:OThwOd88US=> MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ2OUO2PUc,OTJ4NEmzOlk9N2F-
LLC-PK1 MXrGeY5kfGmxbjDhd5NigQ>? MoH2TY5pcWKrdHnvckBw\iCSLXfsfYNweHKxdHXpckwhdW:3c3WgUE1u\HJzYjDlfJBz\XO|ZXSgbY4hVEyFLWDLNUBmeGm2aHXsbYFtKGOnbHzzJJV{cW6pIHPhcINmcW5vQV2gdI9t[XKrc3H0bY9vKGG|c3H5MEBKSzVyPUNOwG0> MlK0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4OUmzPFkoRjF{Nkm5N|g6RC:jPh?=
LLC-PK1 M{LRfmZ2dmO2aX;uJIF{e2G7 Mk\KWHBgXFKDTmPQU3JVTVJ8IHnubIljcXSrb36gc4YhS2GuY3Xpck1CVSCnZn\seZghcW5iTXTyNYIu\XiycnXzd4lv\yCOTFOtVGsyKGOnbHzzMEBKSzVyPUNOwG0> MnqxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4OUmzPFkoRjF{Nkm5N|g6RC:jPh?=
LLC-PK1 Mmf6SpVv[3Srb36gZZN{[Xl? MX\Jcohq[mm2aX;uJI9nKFBvZ3z5Z49xem:2ZXnuMEBpfW2jbjDMMW1FWjFiZYjwdoV{e2WmIHnuJGxNSy2SS{Gg[ZBqfGinbHnhcEBk\WyuczD1d4lv\yClYXzj[YlvNUGPIIDvcIFzcXOjdHnvckBie3OjeTygTWM2OD14LkROwG0> NELLeFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMk[5PVM5QSd-MUK2PVk{QDl:L3G+
LLC-PK1 NF\2SVJHfW6ldHnvckBie3OjeR?= M3LYWXRRZ1SUQV7TVG9TXEWUOjDpcohq[mm2aX;uJI9nKEOjbHPlbY4uSU1iZX\mcJV5KGmwIF3EVlEu\XiycnXzd4lv\yCOTFOtVGsyKGOnbHzzMEBKSzVyPU[uN:69VQ>? MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ7OUO4PUc,OTJ4OUmzPFk9N2F-
LLC-PK1 NX:zUZEzTnWwY4Tpc44h[XO|YYm= NYXRXVNXUW6qaXLpeIlwdiCxZjDQMYdtgWOxcILveIVqdixibX;1d4UhVC2vZIKxZUBmgHC{ZYPz[YQhcW5iTFzDMXBMOSCncHn0bIVtcWGuIHPlcIx{KHW|aX7nJINidGOnaX6tRW0heG:uYYLpd4F1cW:wIHHzd4F6NCCLQ{WwQVEx|ryP MoewQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4OUmzPFkoRjF{Nkm5N|g6RC:jPh?=
LLC-PK1 M4D3eGZ2dmO2aX;uJIF{e2G7 MVXUVH9VWkGQU2DPVnRGWjpiaX7obYJqfGmxbjDv[kBE[WylZXnuMWFOKGWoZnz1fEBqdiCPZIKxZU1mgHC{ZYPzbY5oKEyOQz3QT|Eh[2WubIOsJGlEPTB;MUFOwG0> MonkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4OUmzPFkoRjF{Nkm5N|g6RC:jPh?=
CHO NULGPXV[TnWwY4Tpc44h[XO|YYm= NVz4WGxkUW6qaXLpeIlwdiCxZjDLL{BkcGGwbnXsJIFkfGm4aYT5JIlvKEOKTzDj[YxteyCneIDy[ZN{cW6pIFjFVmchU3ZzMT6xMEBKSzVyPUCuNVQ{|ryP MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjd{OU[3OUc,OTJ5Mkm2O|U9N2F-
mammalian cells NVjmR2VnTnWwY4Tpc44h[XO|YYm= MmDpTY5pcWKrdHnvckBw\iCqdX3hckBRd3Sjc4PpeY0h[2ijbn7lcEBJTVKJIHX4dJJme3OnZDDpckBu[W2vYXzpZY4h[2WubIOsJGlEPTB;MD6xOFEzPc7:TR?= MnfVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ6N{O1NVIoRjF{OEezOVEzRC:jPh?=
AML-2/D100 NVix[pVLTnWwY4Tpc44h[XO|YYm= MlfkWHBgXFKDTmPQU3JVTVJ8IHTyeYchemW|aYP0ZY5k\SBqdnnuZ5Jqe3SrbnWpJIlvKEGPTD2yM2QyODBiY3XscJMtKEmFNUC9NE41|ryP M2ix[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MkSwNVAxLz5zNUK0NFExODxxYU6=
Caco-2 NF[wV5ZHfW6ldHnvckBie3OjeR?= M1K3TnRRZ1SUQV7TVG9TXEWUOjD0doFve2WyaYTo[Yxq[WxidILhcpNxd3K2IH;mJIZmgG:oZX7h[Ilv\SCrbjDDZYNwNTJiY3XscJMtKEmFNUC9PE41PM7:TR?= Ml35QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV|NUm1O|QoRjF3M{W5OVc1RC:jPh?=
KB/MDR Mn[zSpVv[3Srb36gZZN{[Xl? MmDQNUBp M1K2OWNwdmOnboTyZZRqd25idHjheEBk[XW|ZYOgOVAmKG:oIH3hfIlufW1idnnuZoxie3SrbnWgZYNkfW23bHH0bY9vKGmwIFvCM21FWiClZXzsd{BqdiBzIHisJGVEPTB;MUVOwG0> MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTR6MUm5NUc,OTV2OEG5PVE9N2F-
Sf9 MWrGeY5kfGmxbjDhd5NigQ>? NI[3RWpOcWOqYXXsbZMuVWWwdHXuJINwdnO2YX70JIZweiCqdX3hckBRNWeueXPvdJJwfGWrbjDlfJBz\XO|ZXSgbY4hW2Z7IHPlcIx{NCCNbU2y{txO MkO5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV6NkOzNlUoRjF3OE[zN|I2RC:jPh?=
K562 M{ftXGZ2dmO2aX;uJIF{e2G7 MmH5VoV3\XK|YXygc4YhWC2pcD3t[YRq[XSnZDDteYx1cWS{dXegdoV{cXO2YX7j[UBqdiCmb4jvdpVjcWOrbj3y[ZNqe3SjboSgbJVu[W5iS{W2NkBk\WyuczDhd5Nme3OnZDDhd{BlenWpIHPvcoNmdnS{YYTpc44h[2G3c3nu[{Bp[WyoLX3hfIlu[WxiaX7jdoVie2ViaX6gcpVkdGWjcjDwbZJienWkaXPpckBkd26lZX70doF1cW:wLDDBZ5Rqfmm2eU2xMlbPxE1? NVHJfGYyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[yO|k5ODJpPkG2Nlc6QDB{PD;hQi=>
Caco-2 MXXGeY5kfGmxbjDhd5NigQ>? MoXXTY5pcWKrdHnvckBw\iCSZ4CgcYVie3W{ZXSgZZMhcW6qaXLpeIlwdiCxZjDbN2hefmmwYnzhd5RqdmViYnHzc4xifGW{YXygeI8h[XCrY3HsJJRz[W6|cH;yeEBqdiCFYXPvMVIh[2WubIOsJGVEPTB;MkFOwG0> NE[yPYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C2OFA4QSd-MUewOlQxPzl:L3G+
MDA435/LCC6 NI\UT4RHfW6ldHnvckBie3OjeR?= NV\HPGFWWmW4ZYLzZYwhd2ZidnnuZoxie3SrbnWgdoV{cXO2YX7j[UBqdiCvdXz0bYRzfWdicnXzbZN1[W62IF3ERVQ{PS:OQ1O2JINmdGy|IHL5JG1VWyCjc4PhfUwhUUN3ME2wMlAxODJ3zszN NX:1W4NIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexOVQ2ODVpPkG3NVU1PTB3PD;hQi=>
MDA435/LCC6 MVjGeY5kfGmxbjDhd5NigQ>? MoPmVoV3\XK|YXygc4YheGGlbHn0ZZhmdCC{ZYPpd5RidmOnIHnuJI12dHSrZIL1[{Bz\XOrc4ThcpQhVUSDNEO1M2xESzZiY3XscJMh[nliTWTTJIF{e2G7LDDJR|UxRTBwMEC1Nu69VQ>? MmewQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzNUS1NFUoRjF5MUW0OVA2RC:jPh?=
MDA435/LCC6 NGTjfZVHfW6ldHnvckBie3OjeR?= MVjS[ZZmenOjbDDv[kBx[WOuaYThfIVtKHKnc3nzeIFv[2ViaX6gcZVtfGmmcoXnJJJme2m|dHHueEBOTEF2M{WvUGNEPiClZXzsd{BjgSCPVGOgZZN{[XluIFXDOVA:OC55zszN NHjOXHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G1OFUxPSd-MUexOVQ2ODV:L3G+
K562 MljMSpVv[3Srb36gZZN{[Xl? MVfJcohq[mm2aX;uJI9nKGi3bXHuJHBoeCCrbjDhcpRpemGleXPsbY5mNXKnc3nzeIFvfCCNNU[yJINmdGy|IHHzd4V{e2WmIHHzJIRzfWdibHX2[Ywh[2G3c3nu[{Bp[WyoIH3hfIlu[WxiaX7jdoVie2ViaX6gcpVkdGWjcjDjc45k\W62cnH0bY9vKG:oIIDpdoFzfWKrY3nuMEBC[3Srdnn0fV0yNjcQvF2= NWL5NFNiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUeyOVY5OzdpPkG3NlU3QDN5PD;hQi=>
Caco-2 NYXoeFRySW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NECxUXU1QCCqcoO= MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOjY3:tNkBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDifUBOXFRiYYPzZZkh[W[2ZYKgOFghcHK|LDDJR|ExRTJ2LkpOwG0> NEPaPYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{K3OlA4Pid-MUeyO|YxPzZ:L3G+
CEM/VLB500 NUK1cIFCTnWwY4Tpc44h[XO|YYm= M3vQXlMh\GG7cx?= MkfxVoV3\XK|YXygc4YhWC2pcD3t[YRq[XSnZDDteYx1cWS{dXegdoV{cXO2YX7j[UB1dyC4aX7icIF{fGmwZTDpckBpfW2jbjDDSW0wXkyENUCwJINmdGy|IHHmeIVzKDNiZHH5d{BjgSC{ZYPhfpVzcW5iYYPzZZktKEWFNUC9NU4xPDIQvF2= NFrNUJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O5PVk6OCd-MUezPVk6QTB:L3G+
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K562/ADR NFS1cJJHfW6ldHnvckBie3OjeR?= NEHVdXkyOCC2bzCyNEB2VQ>? NFHJRmg{OCCvaX7z MXnJcohq[mm2aX;uJI9nKFBvZ3z5Z49xem:2ZXnuJIlvKGi3bXHuJGs2PjJxQVTSJINmdGy|IHH0JFExKHSxIEKwJJVOKGGodHXyJFMxKG2rboOgZpkhemixZHHtbY5mKDF{MzDzeIFqdmmwZz3iZZNm\CCobIXvdoV{[2WwY3WgZZN{[Xl? NHK5RlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3QTZ4Lze+R4hGVUKOPD;hQi=>
K562 MXzGeY5kfGmxbjDhd5NigQ>? NYftS3Q1OTBidH:gNlAhfU1? NHLGVnIyKGi{ M3vHUmlvcGmkaYTpc44hd2ZiUD3ncJlkd3C{b4TlbY4hcW5iZH;4c5J2[mmlaX6tdoV{cXO2YX70JGhwdW9ic3HwbYVveyBqaIXtZY4qKEt3NkKgZ4VtdHNib4\ldoV5eHKnc4PpcochWC2pcDDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCrboTyZYNmdGy3bHHyJHJpOTJ|IHHjZ5VufWyjdHnvckBifCBzMDD0c{AzOCC3TTDh[pRmeiBzIHjyJIJ6KG[ub4egZ5l1d22ndILpZ{BidmGueYPpdy=> MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly2PVY3Nyd-Q3jFUWJNRC:jPh?=

... Click to View More Cell Line Experimental Data

体内研究 Verapamil通过抑制钙离子内流而具有抗心律失常作用,抑制大鼠心脏氧的消耗,并且同时保存Cx43蛋白。

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 98 mg/mL (199.56 mM)
Water 50 mg/mL (101.82 mM)
Ethanol ''12 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 491.06
化学式

C27H38N2O4.HCl

CAS号 152-11-4
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04406259 Not yet recruiting Drug: Verapamil Cluster Headache Centre Hospitalier Universitaire de Nice September 1 2020 Phase 4
NCT04014634 Recruiting Drug: Methylprednisolone|Other: Placebo Cluster Headache Episodic|Greater Occipital Nerve Injection Leiden University Medical Center|Netherlands Brain Foundation|Innovatiefonds Zorgverzekeraars August 1 2019 Phase 4
NCT02912663 Completed Drug: Verapamil and Magnesium Sulfate|Other: Placebo Ischemic Stroke Justin Fraser|University of Kentucky October 11 2017 Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

Calcium Channel Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID