Calcium Channel

信号通路图

研究领域

抑制剂选择性比较

Calcium Channel产品

目录号 产品描述 文献引用 实验数据
S1573

Fasudil (HA-1077) HCl

Fasudil(HA-1077)是一种有效的、具有选择性的Rho抑制剂(ROCK2, Ki=0.33 μM),同时对PKA、PKG、PKC和MLCK也具有抑制活性,Ki值分别为1.6 μM、1.6 μM、3.3 μM、36 μM。Fasudil 也是calcium channel的阻滞剂。

S1356

Levetiracetam

Levetiracetam (UCB-L059, SIB-S1) 是一种抗癫痫化合物。Levetiracetam (UCB-L059, SIB-S1) 是 muscarinic acetylcholine receptors (mAChR) 的激动剂并能调节突触前P/Q型压敏钙离子通道 calcium (Ca2+) channel

S1813

Amlodipine Besylate

Amlodipine Besylate是一种长效的钙离子通道抑制剂,IC50为1.9 nM。

S1293

Cilnidipine

Cilnidipine (FRC-8653) 是一种L型和N型钙离子通道抑制剂,用来治疗高血压。

S1811

Amiloride HCl

Amiloride是一种选择性的T-type calcium channel阻滞剂,epithelial sodium channel(ENaC)阻滞剂,urokinase plasminogen activator (uPA)抑制剂,Ki=7 μM。

S6920New

SEA0400

SEA0400 是一种选择性的 Na+-Ca2+ exchanger (NCX) 的强效抑制剂,可抑制神经细胞、星形胶质细胞和小胶质细胞中Na+依赖性的Ca2+吸收,对应的IC50值分别为33 nM、5.0 nM和8.3 nM。SEA0400 可防止硝普钠 (SNP) 提高 ERKp38 MAPK 的磷酸化和通过细胞外Ca2+依赖的方式增强reactive oxygen species (ROS) 的产生。

S3242New

Loureirin B

Loureirin B (LB, LrB),是从Dracaena cochinchinensis中提取的类黄酮,是 PAI-1 的抑制剂,其IC50值为26.10 μM。Loureirin B 可下调TGF-β1刺激的成纤维细胞中的 p-ERKp-JNK。Loureirin B 主要通过增加Pdx-1、MafA、细胞内ATP水平来促进胰岛素分泌,抑制 KATP 电流,Ca2+ 进入细胞内。

S6847New

ML-9 HCl

ML-9 HCl (ML-9 hydrochloride) 是一种有效的选择性的 Akt kinasemyosin light chain kinase (MLCK)stromal interaction molecule 1 (STIM1)。ML-9 HCl 也是 Ca2+-permeable channels 的有效抑制剂。ML-9 HCl 是一种靶向自噬和细胞死亡的亲溶酶体剂。

S6834New

CM 4620

CM 4620 是一种 calcium-release activated calcium-channel (CRAC channel) 的抑制剂。CM4620 抑制Orai1/STIM1介导的Ca2+电流和Orai2/STIM1介导的电流,对应的IC50值分别接近120 nM和900 nM。

S0000New

Cav 2.2 blocker 1

Cav 2.2 blocker 1 (compound 9) 是一种 N-type calcium channel (Cav 2.2) 阻滞剂可用于治疗疼痛,其IC50值为0.001 μM。

S0016New

SN-6

SN-6 是一种选择性的 Na+/Ca2+ exchanger (NCX) 抑制剂。SN-6 可抑制NCX1、NCX2和NCX3,对应的IC50值分别为2.9 μM、16 μM和8.6 μM。SN-6 可消除 acetylcholine (ACh) 诱导的血管舒张。

S6657New

2-Aminoethyl Diphenylborinate (2-APB)

2-Aminoethyl Diphenylborinate (2-APB)是IP3 receptor的抑制剂,可以调节IP3诱导的钙释放。2-APB还可以抑制SOC通道的活性,并且在高浓度的时候可以激活TRP通道

S1425

Ranolazine 2HCl

Ranolazine 2HCl (RS-43285)是一种钙离子通过 sodium/calcium channal摄取的抑制剂抗心绞痛药物,用于治疗慢性心绞痛。

S4202

Verapamil HCl

Verapamil HCl是L-型钙通道抑制剂,是第四类抗心律失常的药剂。Verapamil 可抑制 permeability-glycoprotein (P-gp)CYP3A4

S2482

Manidipine 2HCl

Manidipine 2HCl (CV-4093) 是Manidipine的盐酸盐形式,是钙通道阻断剂,IC50为2.6 nM,临床上常用于抗高血压。Phase 4。

S1799

Ranolazine

Ranolazine (CVT 303, RS 43285-003)是一种钙离子通过 sodium/calcium channal摄取的抑制剂抗心绞痛药物,用于治疗慢性心绞痛。

S1662

Isradipine

Isradipine (PN 200-110)是一种高效选择性的L型压力控式钙离子通道抑制剂,用于治疗高血压。

S1905

Amlodipine

Amlodipine (UK-48340) 是一种长效的钙离子通道抑制剂,用于降低血压缓解胸部疼痛。

S1885

Felodipine

Felodipine (CGH-869) 是一种选择性L型Ca2+通道阻断剂,IC50为0.15 nM。

S2481

Manidipine

Manidipine是一种二氢吡啶类钙拮抗剂,用于治疗高血压。

S1748

Nisoldipine

Nisoldipine (Sular, BAY K 5552)是特定L型CaV1.2钙通道阻断剂,IC50为10 nM。

S1747

Nimodipine

Nimodipine (BAY E 9736) 是一种二氢吡啶衍生物,是钙离子通道抑制剂Nifedipine的类似物,具有降压活性。Nimodipine能减少细胞内游离Ca2+,Beclin-1及细胞自噬。

S2721

Nilvadipine

Nilvadipine (ARC029, FR34235) 是一种强效钙通道阻滞剂,IC50为0.03 nM。

S1994

Lacidipine

Lacidipine (GX-1048, GR-43659X, SN-305)是一种L-型钙离子通道抑制剂。

S2114

Dronedarone HCl

Dronedarone HCl (SR33589) 用于治疗阵发性和持续性房颤或房扑的患者。

S4181

Nicardipine HCl

Nicardipine HCl (RS-69216)是二氢吡啶的钙通道抑制剂,具有显著的血管扩张作用。

S1808

Nifedipine

Nifedipine 是一种二氢吡啶类钙离子通道阻滞剂,是有效的血管扩张剂,具有钙拮抗作用。

S2080

Clevidipine Butyrate

Clevidipine Butyrate是一种二氢吡啶类钙离子通道抑制剂,用于降血压。

S2017

Benidipine HCl

Benidipine HCl (KW-3049) 是Benidipine的盐酸盐形式,是一种二氢吡啶类的钙离子通道抑制剂。 

S2030

Flunarizine 2HCl

Flunarizine 2HCl (KW-3149, R14950) 是一种二氢盐酸盐,抑制钙离子通道,Ki为68 nM。

S2491

Nitrendipine

Nitrendipine (Bayotensin) 是一种二氢吡啶类钙离子通道抑制剂,IC50为95 nM。

S3053

Azelnidipine

Azelnidipine (UR-12592)是一种二氢吡啶类钙通道阻断剂。

S2573

Tetracaine HCl

Tetracaine HCl (Amethocalne)是Tetracaine的盐酸盐形式,是一种有效的局部麻醉剂和通道功能变构酶抑制剂。

S1865

Diltiazem HCl

Diltiazem (Tiazac, RG 83606) HCl 是一种Benzothiazepine衍生物,具有舒张血管的作用,由于其抑制钙离子在膜的功能。

S3045

Cinepazide maleate

Cinepazide maleate是cinepazide的马来酸盐形式,而cinepazide是一种血管舒张药。

S5255

Nicardipine

Nicardipine is a potent calcium channel blockader with marked vasodilator action.

S8380

YM-58483 (BTP2)

YM-58483/BTP2是钙池调控钙离子进入(SOCE)的阻滞剂,参与调解不可兴奋细胞如淋巴细胞的激活。

S4626

Ethosuximide

Ethosuximide是一种琥珀酰亚胺类的抗痉挛试剂,主要用于失神发作。是钙离子通道阻滞剂。

S4597

Lercanidipine hydrochloride

Lercanidipine是二氢吡啶类的钙离子通道抑制剂。

S4977

Efonidipine

Efonidipine (NZ-105) 是一种L型和T型钙离子通道阻滞剂,可引起血管舒张和心脏自律性降低。它还能抑制醛固酮从肾上腺分泌。

S5279

Fendiline hydrochloride

Fendiline hydrochloride is the hydrochloride salt form of Fendiline, which is an L-type calcium channel blocker and also a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras.

S3845

Panaxadiol

Panaxadiol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.

S3700

DHBP dibromide

DHBP,一种用于电致色记忆显示剂的紫罗碱,抑制由2 mM咖啡因和2 μg/ml多熔素诱导的钙释放,IC50分别为5 μg/ml和4 μg/ml。

S2403

Tetrandrine

Tetrandrine (Fanchinine)是来源于千金藤根部的一种双苯基异喹啉,一种钙离子通道抑制剂。

S9315

Praeruptorin A

Praeruptorin A, a naturally existing pyranocumarin, is isolated from the dried root of Peucedanum praeruptorum Dunn. Praeruptorin A inhibits p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. Praeruptorin A can significantly upregulates multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.

S3931

Ginsenoside Rd

Ginsenoside Rd, a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity.

S5514

Lanthanum(III) chloride heptahydrate

Lanthanum(III) chloride is the inorganic compound used in biochemical research to block the activity of divalent cation channels, mainly calcium channels.

S3766

Tanshinone IIA sulfonate sodium

Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA isolated as the main pharmacologically active natural compound from a traditional Chinese herbal medicine, the dried root of Salvia miltiorrhiza Bunge known as Danshen. Sodium tanshinone IIA sulfonate (STS) is a potent negative allosteric modulator of the human purinergic receptor P2X7. Sodium tanshinone IIA sulfonate (STS) inhibits the activity of CYP3A4 and store-operated Ca2+ entry (SOCE) through store-operated Ca2+ channels (SOCC) via downregulating the expression of transient receptor potential canonical proteins (TRPC).

S4084

Lomerizine 2HCl

Lomerizine dihydrochloride (KB-2796) 是一种相对较新的L-和T-型钙通道阻滞剂,用于治疗偏头痛。

S4648

Dantrolene sodium hemiheptahydrate

Dantrolene sodium hemiheptahydrate (Dantrium) 是一种骨骼肌松弛药,通过干扰肌纤维中的兴奋-收缩偶联起作用。

S3682

Ethyl 3-Aminobenzoate methanesulfonate

Ethyl 3-Aminobenzoate (Ethyl m-Aminobenzoate, NSC 93790, Tricaine) 可通过voltage-dependent Na+-channels阻止动作电位的产生,常用于鱼类的麻醉、镇静和安乐死。

S9400

Rhynchophylline

Rhynchophylline (Mitrinermine), an active component isolated from species of the genus Uncaria, acts as a calcium channel blocker and is widely used in traditional Chinese medicine mainly for treating ailments of central nervous and cardiovascular systems, such as lightheadedness, convulsions, numbness, and hypertension.

S3674

Levamlodipine

Levamlodipine (S-amlodipine) is a pharmacologically active enantiomer of amlodipine which belongs to the dihydropyridine group of calcium channel blocker. It acts on the L-type of calcium channels and its treatment results in vasodilation and a fall in blood pressure.

S3883

Protopine

Protopine (Corydinine, Fumarine, Biflorine, Macleyine), an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities.

S5567

Trimethadione

Trimethadione is an oxazolidinedione anticonvulsant and often used to treat epileptic conditions that are resistant to other treatments.

S9566

Bepridil hydrochloride

Bepridil hydrochloride是一种抗心绞痛的药物,是钙离子通道(calcium channel)阻滞剂。它能阻止多种其他离子通道,包括钠离子和钾离子通道。

S6473

Pinaverium bromide

Pinaverium bromide是calcium channel阻滞剂,适用于治疗功能性胃肠病。

S4727

Cinnarizine

Cinnarizine (Stugeron, Dimitronal, Stutgin, Cinarizine)是piperazine的药物衍生物,是抗组胺剂钙离子通道阻滞剂。

S2050

Strontium Ranelate

Strontium Ranelate 是Ranelic acid的锶(II)盐,用于(-)-Desmethoxyverapamil结合到钙离子通道,IC50为0.5 mM。

S7924

Bay K 8644

Bay K 8644是一种高选择性的L型钙离子通道激动剂,EC50为17.3 nM。

S4209

Chlorocresol

Chlorocresol 是ryanodine receptor激活剂。

S2436New

Pranidipine

Pranidipine是一种新型的1,4-二氢吡啶 calcium channel 阻滞剂。Pranidipine可以增强cyclic GMP依赖性一氧化氮诱导的大鼠主动脉舒张。

S4931

Propiverine hydrochloride

Propiverine是一种抗胆碱能药物,用于治疗膀胱过度活动症和尿失禁。

S3809

Imperatorin

Imperatorin (Ammidin, Marmelosin, Pentosalen, 8-Isoamylenoxypsoralen), a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle.

S2953

Dooku1

Dooku1 是Yoda1的类似物,具有对 mechanosensitive Piezo1 channel 的拮抗活性。Dooku1 可抑制2 μM Yoda1诱导的Ca2+进入,在HEK 293细胞和HUVECs中的IC50值分别为1.3 μM和1.5 μM。

S5861

Lercanidipine

Lercanidipine是一种对血管具有特异性的钙离子通道拮抗剂,可用于治疗发性高血压。

S9151

Praeruptorin E

Praeruptorin E, isolated from Peucedanum praeruptorum Dunn., is a cardiotonic agent with selective cardiac calcium channel agonistic effect.

S3236New

Mesaconitine

Mesaconitine 是Aconiti tuber附子块茎中的附子生物碱之一,通过从细胞外空间流入Ca2+来增加内皮细胞中的[Ca2+]i水平。

S0973New

Wilforgine

Wilforgine 是 Tripterygium wilfordii Hook. F.中主要的生物活性倍半萜生物碱之一,可在M. separata larvae的肌肉中诱导显微结构和超微结构变化,其发挥作用的位置是肌肉系统中的 calcium receptors or channels

S4353New

Terfenadine

Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.

S2535

Econazole nitrate

Econazole Nitrate (NSC 243115) 是一种咪唑类抗真菌药物。

S2415

Astragaloside A

Astragaloside A是从黄芪中分离的一种纯化的皂苷,广泛应用于治疗心血管疾病。

S2446

Levosimendan

Levosimendan 是一种钙增敏剂,通过与cardiac troponin C (cTnC)结合而发挥作用,这种作用具有钙依赖性。

S1911

Disodium Cromoglycate

Disodium Cromoglycate (FPL 670, Cromolyn) 是一种抗过敏药,IC50为39 μg/mL。

S5478

Dantrolene sodium

Dantrolene sodium acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.

目录号 产品描述 文献引用 实验数据
S1573

Fasudil (HA-1077) HCl

Fasudil(HA-1077)是一种有效的、具有选择性的Rho抑制剂(ROCK2, Ki=0.33 μM),同时对PKA、PKG、PKC和MLCK也具有抑制活性,Ki值分别为1.6 μM、1.6 μM、3.3 μM、36 μM。Fasudil 也是calcium channel的阻滞剂。

S1356

Levetiracetam

Levetiracetam (UCB-L059, SIB-S1) 是一种抗癫痫化合物。Levetiracetam (UCB-L059, SIB-S1) 是 muscarinic acetylcholine receptors (mAChR) 的激动剂并能调节突触前P/Q型压敏钙离子通道 calcium (Ca2+) channel

S1813

Amlodipine Besylate

Amlodipine Besylate是一种长效的钙离子通道抑制剂,IC50为1.9 nM。

S1293

Cilnidipine

Cilnidipine (FRC-8653) 是一种L型和N型钙离子通道抑制剂,用来治疗高血压。

S1811

Amiloride HCl

Amiloride是一种选择性的T-type calcium channel阻滞剂,epithelial sodium channel(ENaC)阻滞剂,urokinase plasminogen activator (uPA)抑制剂,Ki=7 μM。

S6920New

SEA0400

SEA0400 是一种选择性的 Na+-Ca2+ exchanger (NCX) 的强效抑制剂,可抑制神经细胞、星形胶质细胞和小胶质细胞中Na+依赖性的Ca2+吸收,对应的IC50值分别为33 nM、5.0 nM和8.3 nM。SEA0400 可防止硝普钠 (SNP) 提高 ERKp38 MAPK 的磷酸化和通过细胞外Ca2+依赖的方式增强reactive oxygen species (ROS) 的产生。

S3242New

Loureirin B

Loureirin B (LB, LrB),是从Dracaena cochinchinensis中提取的类黄酮,是 PAI-1 的抑制剂,其IC50值为26.10 μM。Loureirin B 可下调TGF-β1刺激的成纤维细胞中的 p-ERKp-JNK。Loureirin B 主要通过增加Pdx-1、MafA、细胞内ATP水平来促进胰岛素分泌,抑制 KATP 电流,Ca2+ 进入细胞内。

S6847New

ML-9 HCl

ML-9 HCl (ML-9 hydrochloride) 是一种有效的选择性的 Akt kinasemyosin light chain kinase (MLCK)stromal interaction molecule 1 (STIM1)。ML-9 HCl 也是 Ca2+-permeable channels 的有效抑制剂。ML-9 HCl 是一种靶向自噬和细胞死亡的亲溶酶体剂。

S6834New

CM 4620

CM 4620 是一种 calcium-release activated calcium-channel (CRAC channel) 的抑制剂。CM4620 抑制Orai1/STIM1介导的Ca2+电流和Orai2/STIM1介导的电流,对应的IC50值分别接近120 nM和900 nM。

S0000New

Cav 2.2 blocker 1

Cav 2.2 blocker 1 (compound 9) 是一种 N-type calcium channel (Cav 2.2) 阻滞剂可用于治疗疼痛,其IC50值为0.001 μM。

S0016New

SN-6

SN-6 是一种选择性的 Na+/Ca2+ exchanger (NCX) 抑制剂。SN-6 可抑制NCX1、NCX2和NCX3,对应的IC50值分别为2.9 μM、16 μM和8.6 μM。SN-6 可消除 acetylcholine (ACh) 诱导的血管舒张。

S6657New

2-Aminoethyl Diphenylborinate (2-APB)

2-Aminoethyl Diphenylborinate (2-APB)是IP3 receptor的抑制剂,可以调节IP3诱导的钙释放。2-APB还可以抑制SOC通道的活性,并且在高浓度的时候可以激活TRP通道

S1425

Ranolazine 2HCl

Ranolazine 2HCl (RS-43285)是一种钙离子通过 sodium/calcium channal摄取的抑制剂抗心绞痛药物,用于治疗慢性心绞痛。

S4202

Verapamil HCl

Verapamil HCl是L-型钙通道抑制剂,是第四类抗心律失常的药剂。Verapamil 可抑制 permeability-glycoprotein (P-gp)CYP3A4

S2482

Manidipine 2HCl

Manidipine 2HCl (CV-4093) 是Manidipine的盐酸盐形式,是钙通道阻断剂,IC50为2.6 nM,临床上常用于抗高血压。Phase 4。

S1799

Ranolazine

Ranolazine (CVT 303, RS 43285-003)是一种钙离子通过 sodium/calcium channal摄取的抑制剂抗心绞痛药物,用于治疗慢性心绞痛。

S1662

Isradipine

Isradipine (PN 200-110)是一种高效选择性的L型压力控式钙离子通道抑制剂,用于治疗高血压。

S1905

Amlodipine

Amlodipine (UK-48340) 是一种长效的钙离子通道抑制剂,用于降低血压缓解胸部疼痛。

S1885

Felodipine

Felodipine (CGH-869) 是一种选择性L型Ca2+通道阻断剂,IC50为0.15 nM。

S2481

Manidipine

Manidipine是一种二氢吡啶类钙拮抗剂,用于治疗高血压。

S1748

Nisoldipine

Nisoldipine (Sular, BAY K 5552)是特定L型CaV1.2钙通道阻断剂,IC50为10 nM。

S1747

Nimodipine

Nimodipine (BAY E 9736) 是一种二氢吡啶衍生物,是钙离子通道抑制剂Nifedipine的类似物,具有降压活性。Nimodipine能减少细胞内游离Ca2+,Beclin-1及细胞自噬。

S2721

Nilvadipine

Nilvadipine (ARC029, FR34235) 是一种强效钙通道阻滞剂,IC50为0.03 nM。

S1994

Lacidipine

Lacidipine (GX-1048, GR-43659X, SN-305)是一种L-型钙离子通道抑制剂。

S2114

Dronedarone HCl

Dronedarone HCl (SR33589) 用于治疗阵发性和持续性房颤或房扑的患者。

S4181

Nicardipine HCl

Nicardipine HCl (RS-69216)是二氢吡啶的钙通道抑制剂,具有显著的血管扩张作用。

S1808

Nifedipine

Nifedipine 是一种二氢吡啶类钙离子通道阻滞剂,是有效的血管扩张剂,具有钙拮抗作用。

S2080

Clevidipine Butyrate

Clevidipine Butyrate是一种二氢吡啶类钙离子通道抑制剂,用于降血压。

S2017

Benidipine HCl

Benidipine HCl (KW-3049) 是Benidipine的盐酸盐形式,是一种二氢吡啶类的钙离子通道抑制剂。 

S2030

Flunarizine 2HCl

Flunarizine 2HCl (KW-3149, R14950) 是一种二氢盐酸盐,抑制钙离子通道,Ki为68 nM。

S2491

Nitrendipine

Nitrendipine (Bayotensin) 是一种二氢吡啶类钙离子通道抑制剂,IC50为95 nM。

S3053

Azelnidipine

Azelnidipine (UR-12592)是一种二氢吡啶类钙通道阻断剂。

S2573

Tetracaine HCl

Tetracaine HCl (Amethocalne)是Tetracaine的盐酸盐形式,是一种有效的局部麻醉剂和通道功能变构酶抑制剂。

S1865

Diltiazem HCl

Diltiazem (Tiazac, RG 83606) HCl 是一种Benzothiazepine衍生物,具有舒张血管的作用,由于其抑制钙离子在膜的功能。

S3045

Cinepazide maleate

Cinepazide maleate是cinepazide的马来酸盐形式,而cinepazide是一种血管舒张药。

S5255

Nicardipine

Nicardipine is a potent calcium channel blockader with marked vasodilator action.

S8380

YM-58483 (BTP2)

YM-58483/BTP2是钙池调控钙离子进入(SOCE)的阻滞剂,参与调解不可兴奋细胞如淋巴细胞的激活。

S4626

Ethosuximide

Ethosuximide是一种琥珀酰亚胺类的抗痉挛试剂,主要用于失神发作。是钙离子通道阻滞剂。

S4597

Lercanidipine hydrochloride

Lercanidipine是二氢吡啶类的钙离子通道抑制剂。

S4977

Efonidipine

Efonidipine (NZ-105) 是一种L型和T型钙离子通道阻滞剂,可引起血管舒张和心脏自律性降低。它还能抑制醛固酮从肾上腺分泌。

S5279

Fendiline hydrochloride

Fendiline hydrochloride is the hydrochloride salt form of Fendiline, which is an L-type calcium channel blocker and also a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras.

S3845

Panaxadiol

Panaxadiol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.

S3700

DHBP dibromide

DHBP,一种用于电致色记忆显示剂的紫罗碱,抑制由2 mM咖啡因和2 μg/ml多熔素诱导的钙释放,IC50分别为5 μg/ml和4 μg/ml。

S2403

Tetrandrine

Tetrandrine (Fanchinine)是来源于千金藤根部的一种双苯基异喹啉,一种钙离子通道抑制剂。

S9315

Praeruptorin A

Praeruptorin A, a naturally existing pyranocumarin, is isolated from the dried root of Peucedanum praeruptorum Dunn. Praeruptorin A inhibits p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. Praeruptorin A can significantly upregulates multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.

S3931

Ginsenoside Rd

Ginsenoside Rd, a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity.

S5514

Lanthanum(III) chloride heptahydrate

Lanthanum(III) chloride is the inorganic compound used in biochemical research to block the activity of divalent cation channels, mainly calcium channels.

S3766

Tanshinone IIA sulfonate sodium

Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA isolated as the main pharmacologically active natural compound from a traditional Chinese herbal medicine, the dried root of Salvia miltiorrhiza Bunge known as Danshen. Sodium tanshinone IIA sulfonate (STS) is a potent negative allosteric modulator of the human purinergic receptor P2X7. Sodium tanshinone IIA sulfonate (STS) inhibits the activity of CYP3A4 and store-operated Ca2+ entry (SOCE) through store-operated Ca2+ channels (SOCC) via downregulating the expression of transient receptor potential canonical proteins (TRPC).

S4084

Lomerizine 2HCl

Lomerizine dihydrochloride (KB-2796) 是一种相对较新的L-和T-型钙通道阻滞剂,用于治疗偏头痛。

S4648

Dantrolene sodium hemiheptahydrate

Dantrolene sodium hemiheptahydrate (Dantrium) 是一种骨骼肌松弛药,通过干扰肌纤维中的兴奋-收缩偶联起作用。

S3682

Ethyl 3-Aminobenzoate methanesulfonate

Ethyl 3-Aminobenzoate (Ethyl m-Aminobenzoate, NSC 93790, Tricaine) 可通过voltage-dependent Na+-channels阻止动作电位的产生,常用于鱼类的麻醉、镇静和安乐死。

S9400

Rhynchophylline

Rhynchophylline (Mitrinermine), an active component isolated from species of the genus Uncaria, acts as a calcium channel blocker and is widely used in traditional Chinese medicine mainly for treating ailments of central nervous and cardiovascular systems, such as lightheadedness, convulsions, numbness, and hypertension.

S3674

Levamlodipine

Levamlodipine (S-amlodipine) is a pharmacologically active enantiomer of amlodipine which belongs to the dihydropyridine group of calcium channel blocker. It acts on the L-type of calcium channels and its treatment results in vasodilation and a fall in blood pressure.

S3883

Protopine

Protopine (Corydinine, Fumarine, Biflorine, Macleyine), an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities.

S5567

Trimethadione

Trimethadione is an oxazolidinedione anticonvulsant and often used to treat epileptic conditions that are resistant to other treatments.

S9566

Bepridil hydrochloride

Bepridil hydrochloride是一种抗心绞痛的药物,是钙离子通道(calcium channel)阻滞剂。它能阻止多种其他离子通道,包括钠离子和钾离子通道。

S6473

Pinaverium bromide

Pinaverium bromide是calcium channel阻滞剂,适用于治疗功能性胃肠病。

S4727

Cinnarizine

Cinnarizine (Stugeron, Dimitronal, Stutgin, Cinarizine)是piperazine的药物衍生物,是抗组胺剂钙离子通道阻滞剂。

目录号 产品描述 文献引用 实验数据
S2050

Strontium Ranelate

Strontium Ranelate 是Ranelic acid的锶(II)盐,用于(-)-Desmethoxyverapamil结合到钙离子通道,IC50为0.5 mM。

S7924

Bay K 8644

Bay K 8644是一种高选择性的L型钙离子通道激动剂,EC50为17.3 nM。

S4209

Chlorocresol

Chlorocresol 是ryanodine receptor激活剂。

目录号 产品描述 文献引用 实验数据
S2436New

Pranidipine

Pranidipine是一种新型的1,4-二氢吡啶 calcium channel 阻滞剂。Pranidipine可以增强cyclic GMP依赖性一氧化氮诱导的大鼠主动脉舒张。

S4931

Propiverine hydrochloride

Propiverine是一种抗胆碱能药物,用于治疗膀胱过度活动症和尿失禁。

S3809

Imperatorin

Imperatorin (Ammidin, Marmelosin, Pentosalen, 8-Isoamylenoxypsoralen), a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle.

S2953

Dooku1

Dooku1 是Yoda1的类似物,具有对 mechanosensitive Piezo1 channel 的拮抗活性。Dooku1 可抑制2 μM Yoda1诱导的Ca2+进入,在HEK 293细胞和HUVECs中的IC50值分别为1.3 μM和1.5 μM。

S5861

Lercanidipine

Lercanidipine是一种对血管具有特异性的钙离子通道拮抗剂,可用于治疗发性高血压。

目录号 产品描述 文献引用 实验数据
S9151

Praeruptorin E

Praeruptorin E, isolated from Peucedanum praeruptorum Dunn., is a cardiotonic agent with selective cardiac calcium channel agonistic effect.

目录号 产品描述 文献引用 实验数据
S3236New

Mesaconitine

Mesaconitine 是Aconiti tuber附子块茎中的附子生物碱之一,通过从细胞外空间流入Ca2+来增加内皮细胞中的[Ca2+]i水平。

S0973New

Wilforgine

Wilforgine 是 Tripterygium wilfordii Hook. F.中主要的生物活性倍半萜生物碱之一,可在M. separata larvae的肌肉中诱导显微结构和超微结构变化,其发挥作用的位置是肌肉系统中的 calcium receptors or channels

S4353New

Terfenadine

Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.

S2535

Econazole nitrate

Econazole Nitrate (NSC 243115) 是一种咪唑类抗真菌药物。

S2415

Astragaloside A

Astragaloside A是从黄芪中分离的一种纯化的皂苷,广泛应用于治疗心血管疾病。

目录号 产品描述 文献引用 实验数据
S2446

Levosimendan

Levosimendan 是一种钙增敏剂,通过与cardiac troponin C (cTnC)结合而发挥作用,这种作用具有钙依赖性。

S1911

Disodium Cromoglycate

Disodium Cromoglycate (FPL 670, Cromolyn) 是一种抗过敏药,IC50为39 μg/mL。

S5478

Dantrolene sodium

Dantrolene sodium acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.