Calcium Channel

信号通路图

研究领域

抑制剂选择性比较
溶解性比较

目录号	产品目录	溶解度(25°C)
目录号	产品目录	水	DMSO	酒精
S1356	Levetiracetam	34 mg/mL	34 mg/mL	34 mg/mL
S1813	Amlodipine Besylate	<1 mg/mL	113 mg/mL	14 mg/mL
S1293	Cilnidipine	<1 mg/mL	99 mg/mL	15 mg/mL
S1811	Amiloride HCl	6 mg/mL	53 mg/mL	5 mg/mL
S1425	Ranolazine 2HCl	100 mg/mL	100 mg/mL	<1 mg/mL
S9566	Bepridil hydrochloride	-1 mg/mL	41 mg/mL	-1 mg/mL
S5255	Nicardipine	30 mg/mL	95 mg/mL	95 mg/mL
S9400	Rhynchophylline	-1 mg/mL	76 mg/mL	-1 mg/mL
S5514	Lanthanum(III) chloride heptahydrate	-1 mg/mL	50 mg/mL	-1 mg/mL
S5279	Fendiline hydrochloride	-1 mg/mL	70 mg/mL	-1 mg/mL
S4977	Efonidipine	-1 mg/mL	100 mg/mL	40 mg/mL
S8691	ML204	<1 mg/mL	45 mg/mL	45 mg/mL
S3867	(E)-Cardamoni	-1 mg/mL	54 mg/mL	-1 mg/mL
S3883	Protopine	-1 mg/mL	30 mg/mL	-1 mg/mL
S3845	Panaxadiol	<1 mg/mL	<1 mg/mL	22 mg/mL
S4202	Verapamil HCl	50 mg/mL	98 mg/mL	12 mg/mL
S2482	Manidipine 2HCl	<1 mg/mL	21 mg/mL	<1 mg/mL
S1799	Ranolazine	<1 mg/mL	86 mg/mL	20 mg/mL
S1662	Isradipine	<1 mg/mL	74 mg/mL	74 mg/mL
S1905	Amlodipine	<1 mg/mL	82 mg/mL	82 mg/mL
S1885	Felodipine	<1 mg/mL	77 mg/mL	72 mg/mL
S2481	Manidipine	<1 mg/mL	122 mg/mL	3 mg/mL
S1748	Nisoldipine	<1 mg/mL	77 mg/mL	60 mg/mL
S1747	Nimodipine	<1 mg/mL	84 mg/mL	84 mg/mL
S2721	Nilvadipine	<1 mg/mL	77 mg/mL	33 mg/mL
S1994	Lacidipine	<1 mg/mL	91 mg/mL	22 mg/mL
S2114	Dronedarone HCl	<1 mg/mL	80 mg/mL	40 mg/mL
S4181	Nicardipine HCl	<1 mg/mL	100 mg/mL	<1 mg/mL
S1808	Nifedipine	<1 mg/mL	69 mg/mL	15 mg/mL
S2080	Clevidipine Butyrate	<1 mg/mL	91 mg/mL	3 mg/mL
S2017	Benidipine HCl	<1 mg/mL	8 mg/mL	<1 mg/mL
S2918	HC-030031	<1 mg/mL	32 mg/mL	<1 mg/mL
S2030	Flunarizine 2HCl	<1 mg/mL	5 mg/mL	3 mg/mL
S2491	Nitrendipine	<1 mg/mL	72 mg/mL	<1 mg/mL
S3053	Azelnidipine	<1 mg/mL	117 mg/mL	7 mg/mL
S2573	Tetracaine HCl	60 mg/mL	60 mg/mL	30 mg/mL
S1865	Diltiazem HCl	90 mg/mL	90 mg/mL	4 mg/mL
S7999	SKF96365	80 mg/mL	80 mg/mL	80 mg/mL
S3045	Cinepazide maleate	107 mg/mL	107 mg/mL	<1 mg/mL
S8380	YM-58483 (BTP2)	<1 mg/mL	84 mg/mL	84 mg/mL
S4626	Ethosuximide	28 mg/mL	28 mg/mL	28 mg/mL
S4597	Lercanidipine hydrochloride	<1 mg/mL	66 mg/mL	1 mg/mL
S3700	DHBP dibromide	100 mg/mL	100 mg/mL	100 mg/mL
S2403	Tetrandrine	<1 mg/mL	1 mg/mL	2 mg/mL
S4084	Lomerizine 2HCl	<1 mg/mL	100 mg/mL	52 mg/mL
S4648	Dantrolene sodium hemiheptahydrate	<1 mg/mL	14 mg/mL	<1 mg/mL
S3682	Ethyl 3-Aminobenzoate methanesulfonate	52 mg/mL	52 mg/mL	52 mg/mL
S3674	Levamlodipine	81 mg/mL	81 mg/mL	81 mg/mL
S4727	Cinnarizine	<1 mg/mL	73 mg/mL	<1 mg/mL
S2050	Strontium Ranelate	<1 mg/mL	<1 mg/mL	<1 mg/mL
S8073	Optovin	<1 mg/mL	63 mg/mL	<1 mg/mL
S7924	Bay K 8644	<1 mg/mL	71 mg/mL	71 mg/mL
S4209	Chlorocresol	<1 mg/mL	29 mg/mL	29 mg/mL
S3809	Imperatorin	-1 mg/mL	54 mg/mL	-1 mg/mL
S3942	Cardamonin	<1 mg/mL	54 mg/mL	54 mg/mL
S9151	Praeruptorin E	-1 mg/mL	34.6 mg/mL	-1 mg/mL
S4787	Methyl syringate	-1 mg/mL	42 mg/mL	-1 mg/mL
S2535	Econazole nitrate	<1 mg/mL	89 mg/mL	5 mg/mL
S2415	Astragaloside A	<1 mg/mL	100 mg/mL	<1 mg/mL
S5478	Dantrolene sodium	-1 mg/mL	67 mg/mL	-1 mg/mL
S2446	Levosimendan	<1 mg/mL	56 mg/mL	<1 mg/mL
S1911	Disodium Cromoglycate	2 mg/mL	<1 mg/mL	<1 mg/mL

Calcium Channel抑制剂（62）
新Calcium Channel产品

产品目录	产品描述	文献引用	实验数据
S1356	Levetiracetam Levetiracetam是一种抗癫痫化合物。	Sci Rep, 2016, 6:25705 Sci Rep, 2016, 6:25705	Levetiracetam reduces DNA, synaptic, and neurite damage caused by Dox. (A) An example of cortical cultures pre-treated with 5 μ M Lev and then Dox (0.01 μ M, overnight), fixed and stained with antibodies against MAP2c. Scale bar is 20 μ m. (B) Cortical neurons at 28–32 DIV were pre-treated with 5 μ M Lev, and then a vehicle or with Dox (0.01 μ M for 3 days, or 0.1 μ M, overnight) was added. Neurons were fixed, and stained for MAP2c, synapsin, and with the Hoechst dye, and imaged. Note that red MAP2c staining also includes Dox's red fluorescence. (C) Synaptically developed primary cortical cultures at 28−32 DIV were pretreated with 5 mM Lev, and then a vehicle or with Dox (0.01 μM for 3 days, or 0.1 μM, overnight) was added. Neurons were then fixed, and stained with antibodies against γH2A.X and MAP2c, and with the Hoechst dye. Blue staining was used by the algorithm to identify and analyze γH2A.X.
S1813	Amlodipine Besylate Amlodipine Besylate是一种长效的钙离子通道抑制剂，IC50为1.9 nM。
S1293	Cilnidipine Cilnidipine是一种L型和N型钙离子通道抑制剂，用来治疗高血压。
S1811	Amiloride HCl Amiloride是一种选择性的T-type calcium channel阻滞剂，epithelial sodium channel（ENaC）阻滞剂，urokinase plasminogen activator (uPA)抑制剂，Ki=7 μM。	Environ Sci Technol, 2013, 47(18):10601-10 Atherosclerosis, 2015, 239(1):252-9
S1425	Ranolazine 2HCl Ranolazine 2HCl是一种钙离子通过 sodium/calcium channal摄取的抑制剂抗心绞痛药物，用于治疗慢性心绞痛。
S9566^New	Bepridil hydrochloride Bepridil hydrochloride是一种抗心绞痛的药物，是钙离子通道（calcium channel）阻滞剂。它能阻止多种其他离子通道，包括钠离子和钾离子通道。
S5255^New	Nicardipine Nicardipine is a potent calcium channel blockader with marked vasodilator action.
S9400^New	Rhynchophylline Rhynchophylline, an active component isolated from species of the genus Uncaria, acts as a calcium channel blocker and is widely used in traditional Chinese medicine mainly for treating ailments of central nervous and cardiovascular systems, such as lightheadedness, convulsions, numbness, and hypertension.
S5514^New	Lanthanum(III) chloride heptahydrate Lanthanum(III) chloride is the inorganic compound used in biochemical research to block the activity of divalent cation channels, mainly calcium channels.
S5279^New	Fendiline hydrochloride Fendiline hydrochloride is the hydrochloride salt form of Fendiline, which is an L-type calcium channel blocker and also a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras.
S4977^New	Efonidipine Efonidipine是一种L型和T型钙离子通道阻滞剂，可引起血管舒张和心脏自律性降低。它还能抑制醛固酮从肾上腺分泌。
S8691^New	ML204 ML204是新型的、有效的、选择性的TRPC4抑制剂。在胞内钙离子荧光分析试验中，IC50为1 μM。在全细胞电压钳实验中，IC50约为3 μM。ML204对TRPC通道的选择性远高于对其他TRP通道和非TRP通道的选择性。
S3867^New	(E)-Cardamoni Cardamonin is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.
S3883^New	Protopine Protopine, an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities.
S3845^New	Panaxadiol Panaxadiol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.
S4202	Verapamil HCl Verapamil HCl是L-型钙通道抑制剂，是第四类抗心律失常的药剂。	BMC Cancer, 2015, 10.1186/s12885-015-1543-z Front Pharmacol, 2018, 9:1298 Exp Hematol, 2017, 52:65-71	f, Cells were pretreated with or without 5 μM verapamil and then treated with the indicated concentrations of 17-DMAG for 6 h. The proteins involved in ALK-related signaling were detected by western blot analysis.
S2482	Manidipine 2HCl Manidipine 2HCl是Manidipine的盐酸盐形式，是钙通道阻断剂，IC50为2.6 nM，临床上常用于抗高血压。Phase 4。		Manidipine decreases the accumulation of HCMV Early and Late proteins. HFFs were infected with HCMV AD169 and then treated with test compounds or DMSO as a control. NTZ-treated samples were also included as a control for inhibition of E and L protein expression. At the indicated times p.i., total cell extracts were prepared and analyzed by WB with anti-IEA, anti-UL44, and anti-UL99 antibodies. Tubulin immunodetection served as a loading control. Images are representative of three independent experiments.
S1799	Ranolazine Ranolazine 2HCl是一种钙离子通过 sodium/calcium channal摄取的抑制剂抗心绞痛药物，用于治疗慢性心绞痛。
S1662	Isradipine Isradipine是一种高效选择性的L型压力控式钙离子通道抑制剂，用于治疗高血压。
S1905	Amlodipine Amlodipine 是一种长效的钙离子通道抑制剂，用于降低血压缓解胸部疼痛。
S1885	Felodipine Felodipine 是一种选择性L型Ca²⁺通道阻断剂，IC50为0.15 nM。
S2481	Manidipine Manidipine是一种二氢吡啶类钙拮抗剂，用于治疗高血压。
S1748	Nisoldipine Nisoldipine是特定L型CaV1.2钙通道阻断剂，IC50为10 nM。
S1747	Nimodipine Nimodipine是一种二氢吡啶衍生物，是钙离子通道抑制剂Nifedipine的类似物，具有降压活性。Nimodipine能减少细胞内游离Ca2+，Beclin-1及细胞自噬。	Antiviral Res, 2016, 132:38-45	Assessment of the role of Ca2+ channels during RSV replication. HEp-2 cells were infected with RSV strain long at an MOI of 0.1, and treated with calcium channel blockers nifedipine, nimodipine, and tetrandrine (A), at indicated concentrations. Supernatants were collected at 48 h postinfection and viral titers were determined by immunoplaque assay. Grey bars represent cytotoxicity of the compounds. The data presented were obtained from two independent experiments. Error bars represent the standard deviations from two independent experiments. NS, no differences at a significance level of 0.05.
S2721	Nilvadipine Nilvadipine是一种强效钙通道阻滞剂，IC50为0.03 nM。
S1994	Lacidipine Lacidipine 是一种L-型钙离子通道抑制剂。
S2114	Dronedarone HCl Dronedarone HCl 用于治疗阵发性和持续性房颤或房扑的患者。	Nat Commun, 2016, 7:13023	Results of hit validation experiments for these four compounds for animals treated at L1 stage at four different concentrations (0.5, 5, 25, and 50 μM). The blue bars represent the values obtained from the original screen as reference points. Error bars are standard error of the mean. Statistical significance for all different doses for individual compounds was calculated with respect to the lowest concentration using two-tailed, t-test (nZ70 animals except n = 37 for Geld 25 μM). The statistical significance values are represented as P<0.05 () and P<0.005 (*).
S4181	Nicardipine HCl Nicardipine HCl是二氢吡啶的钙通道抑制剂，具有显著的血管扩张作用。
S1808	Nifedipine Nifedipine 是一种二氢吡啶类钙离子通道阻滞剂，是有效的血管扩张剂，具有钙拮抗作用。	Antiviral Res, 2016, 132:38-45 Toxicol Appl Pharmacol, 2015, 285(1):51-60 Dev Biol, 2017, 421(2):149-160	The fold change of C-peptide content after octreotide, nicorandil and nifedipine treatment. Octreotide, nicorandil and nifedipine decreased insulin secretion in wild-type, heterozygous mutated and homozygous mutated cells.
S2080	Clevidipine Butyrate Clevidipine Butyrate是一种二氢吡啶类钙离子通道抑制剂，用于降血压。
S2017	Benidipine HCl Benidipine HCl是Benidipine的盐酸盐形式，是一种二氢吡啶类的钙离子通道抑制剂。
S2918	HC-030031 HC-030031是一种选择性的TRPA1通道阻断剂，可以拮抗AITC和formalin引起的钙流入，IC50分别为6.2μM和5.3μM。
S2030	Flunarizine 2HCl Flunarizine 2HCl是一种二氢盐酸盐，抑制钙离子通道，K_i为68 nM。
S2491	Nitrendipine Nitrendipine是一种二氢吡啶类钙离子通道抑制剂，IC50为95 nM。
S3053	Azelnidipine Azelnidipine是一种二氢吡啶类钙通道阻断剂。
S2573	Tetracaine HCl Tetracaine HCl 是Tetracaine的盐酸盐形式，是一种有效的局部麻醉剂和通道功能变构酶抑制剂。
S1865	Diltiazem HCl Diltiazem HCl 是一种Benzothiazepine衍生物，具有舒张血管的作用，由于其抑制钙离子在膜的功能。	FASEB J, 2017, 31(2):625-635 J Cell Mol Med, 2018, 22(12):5964-5977
S7999	SKF96365 SKF96365，最初认为是钙通道阻滞剂，目前作为TRPC通道阻滞剂，被广泛用于医疗诊断。
S3045	Cinepazide maleate Cinepazide maleate是cinepazide的马来酸盐形式，而cinepazide是一种血管舒张药。
S8380	YM-58483 (BTP2) YM-58483/BTP2是钙池调控钙离子进入（SOCE）的阻滞剂，参与调解不可兴奋细胞如淋巴细胞的激活。
S4626	Ethosuximide Ethosuximide是一种琥珀酰亚胺类的抗痉挛试剂，主要用于失神发作。是钙离子通道阻滞剂。	Nature, 2018, 554(7692):317-322	Antidepressant effects caused by systemic ethosuximide injection (200 mg kg−1, i.p.; c, d) in the FST(forced swim test) and SPT (sucrose preference test) 1 h after treatment.
S4597	Lercanidipine hydrochloride Lercanidipine是二氢吡啶类的钙离子通道抑制剂。	J Phys Chem B, 2013, 117(23):6868-73
S3700	DHBP dibromide DHBP，一种用于电致色记忆显示剂的紫罗碱，抑制由2 mM咖啡因和2 μg/ml多熔素诱导的钙释放，IC50分别为5 μg/ml和4 μg/ml。
S2403	Tetrandrine Tetrandrine是来源于千金藤根部的一种双苯基异喹啉，一种钙离子通道抑制剂。	Antiviral Res, 2016, 132:38-45 Biochem Biophys Res Commun, 2016, 476(4):481-6 FASEB J, 2018, 32(6):3398-3410	(B) Measurement of the cellular LDs in 3T3-L1 preadipocytes (undifferentiated) or differentiated adipocytes on day 8 by Oil Red O staining. Phase-contrast images of the cells were also taken after the treatment (lower panels in B). Each picture in (B) is a representative of three independent experiments. (C) Quantification of the cellular TG contents in tetrandrine-treated 3T3-L1 preadipocytes on day 8 by AdipoRed assay. Values are mean ± SE of data from three independent experiments with three replicates. P < 0.05 vs.control (no chemical). (D) 3T3-L1 preadipocytes were grown under the above-mentioned 3T3-L1 preadipocyte differentiation condition in Figure 1A. On day 8, tetrandrine-treated 3T3-L1 preadipocytes, which cannot be stained with trypan blue dye, was counted under microscope. The cell count assay was done in triplicates. Data are mean ± SE of three independent experiments. P < 0.05 vs. control (no chemical).
S4084	Lomerizine 2HCl Lomerizine dihydrochloride是一种相对较新的L-和T-型钙通道阻滞剂，用于治疗偏头痛。
S4648	Dantrolene sodium hemiheptahydrate Dantrolene sodium hemiheptahydrate是一种骨骼肌松弛药，通过干扰肌纤维中的兴奋-收缩偶联起作用。
S3682	Ethyl 3-Aminobenzoate methanesulfonate Ethyl 3-Aminobenzoate可通过voltage-dependent Na+-channels阻止动作电位的产生，常用于鱼类的麻醉、镇静和安乐死。
S3674	Levamlodipine Levamlodipine is a pharmacologically active enantiomer of amlodipine which belongs to the dihydropyridine group of calcium channel blocker. It acts on the L-type of calcium channels and its treatment results in vasodilation and a fall in blood pressure.
S4727	Cinnarizine Cinnarizine是piperazine的药物衍生物，是抗组胺剂和钙离子通道阻滞剂。
S2050	Strontium Ranelate Strontium Ranelate 是Ranelic acid的锶（II）盐，用于(-)-Desmethoxyverapamil结合到钙离子通道，IC50为0.5 mM。
S8073	Optovin Optovin是一个可逆的光活化的TRPA1活化剂。
S7924	Bay K 8644 Bay K 6244是一种高选择性的L型钙离子通道激动剂，EC50为17.3 nM。	J Cell Physiol, 2018, 10.1002/jcp.27791
S4209	Chlorocresol Chlorocresol 是ryanodine receptor激活剂。
S3809^New	Imperatorin Imperatorin, a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle.
S3942	Cardamonin Cardamonin天然存在于良姜属物种的果实中，具有抗炎和抗肿瘤活性。它是一种新型的hTRPA1离子通道拮抗剂，IC50为454 nM，而不与TRPV1和TRPV4相互作用。
S9151^New	Praeruptorin E Praeruptorin E, isolated from Peucedanum praeruptorum Dunn., is a cardiotonic agent with selective cardiac calcium channel agonistic effect.
S4787^New	Methyl syringate Methyl syringate, a plant phenolic compound, is a specific and selective TRPA1 agonist.
S2535	Econazole nitrate Econazole nitrate 是一种咪唑类抗真菌药物。
S2415	Astragaloside A Astragaloside A是从黄芪中分离的一种纯化的皂苷，广泛应用于治疗心血管疾病。
S5478^New	Dantrolene sodium Dantrolene sodium acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.
S2446	Levosimendan Levosimendan 是一种钙增敏剂，通过与cardiac troponin C (cTnC)结合而发挥作用，这种作用具有钙依赖性。	Antiviral Res, 2017, 146:76-85	(B-E) The % of GFP-positive cells upon compound treatment were determined for the indicated HIV-1 latency cell lines (B. J-LAT 6.3; C. JLAT 10.6; D. CA5; E. EF7). Results were normalized to DMSO control. Values represent the mean ± s.d. (n = 4-6). * p < 0.05, one-way ANOVA followed by Tukey’s multiplecomparison test
S1911	Disodium Cromoglycate Disodium Cromoglycate是一种抗过敏药，IC50为39 μg/mL。

研究领域

产品类型

Calcium Channel

信号通路图

研究领域