S1573 |
Fasudil (HA-1077) HCl
|
Fasudil (HA-1077, AT-877)是一种有效的、具有选择性的Rho抑制剂(ROCK2, Ki=0.33 μM),同时对PKA、PKG、PKC和MLCK也具有抑制活性,Ki值分别为1.6 μM、1.6 μM、3.3 μM、36 μM。Fasudil 也是calcium channel的阻滞剂。 |
-
Aging Cell, 2022, e13587
-
Cell Death Dis, 2022, 13(2):138
-
iScience, 2022, 25(6):104398
|
|
S1356 |
Levetiracetam (UCB-L059)
|
Levetiracetam (UCB-L059, SIB-S1) 是一种抗癫痫化合物。Levetiracetam (UCB-L059, SIB-S1) 是 muscarinic acetylcholine receptors (mAChR) 的激动剂并能调节突触前P/Q型压敏钙离子通道 calcium (Ca2+) channel。 |
-
Anticancer Res, 2021, 41(2):687-697
-
PLoS One, 2019, 14(2):e0211644
-
Sci Rep, 2016, 6:25705
|
|
S1813 |
Amlodipine Besylate
|
Amlodipine Besylate是一种长效的钙离子通道抑制剂,IC50为1.9 nM。 |
-
Cell Discov, 2020, 6(1):96
-
Oncogene, 2019, 38(1):120-139
|
|
S1293 |
Cilnidipine (FRC-8653)
|
Cilnidipine (FRC-8653) 是一种L型和N型钙离子通道抑制剂,用来治疗高血压。 |
-
ACS Infect Dis, 2020, acsinfecdis.0c00486
-
Cell Discov, 2020, 6(1):96
-
Res Sq, 2020, rs.3.rs-48659
|
|
S1811 |
Amiloride (MK-870) HCl
|
Amiloride (MK-870)是一种选择性的T-type calcium channel阻滞剂,epithelial sodium channel(ENaC)阻滞剂,urokinase plasminogen activator (uPA)抑制剂,Ki=7 μM。 |
-
Mol Ther Methods Clin Dev, 2022, 24:11-19
-
Adv Sci (Weinh), 2021, 8(13):2100962
-
Theranostics, 2021, 11(5):2364-2380
|
|
E0778New |
o-3M3FBS
|
O-3M3FBS是m-3M3FBS的阴性对照,以独立于PLC的机制及拮抗的方式抑制内向和外向电流,可逆地抑制延迟整流K+通道,以与m-3M3FBS竞争的形式增加[Ca2+](i)。 |
|
|
E0826New |
Levamlodipine Besylate
|
Levamlodipine Besylate是一种强大的二氢吡啶钙通道(dihydropyridine calcium channel)阻滞剂,具有血管舒张特性,用于高血压和心绞痛的治疗。 |
|
|
S1425 |
Ranolazine 2HCl
|
Ranolazine 2HCl (RS-43285)是一种钙离子通过 sodium/calcium channal摄取的抑制剂抗心绞痛药物,用于治疗慢性心绞痛。 |
-
Front Pharmacol, 2019, 10:1367
|
|
S4202 |
Verapamil (CP-16533-1) HCl
|
Verapamil HCl (CP-16533-1)是L-型钙通道抑制剂,是第四类抗心律失常的药剂。Verapamil 可抑制 permeability-glycoprotein (P-gp) 和 CYP3A4。 |
-
EMBO Mol Med, 2022, 14(2):e14903
-
Cell Rep, 2022, 38(10):110468
-
ACS Nano, 2021, 10.1021/acsnano.1c03517
|
|
S2482 |
Manidipine 2HCl
|
Manidipine 2HCl (CV-4093) 是Manidipine的盐酸盐形式,是钙通道阻断剂,IC50为2.6 nM,临床上常用于抗高血压。Phase 4。 |
-
Environ Toxicol Chem, 2021, 10.1002/etc.5018
|
|
S1799 |
Ranolazine
|
Ranolazine (CVT 303, RS 43285-003)是一种钙离子通过 sodium/calcium channal摄取的抑制剂抗心绞痛药物,用于治疗慢性心绞痛。 |
|
|
S1662 |
Isradipine
|
Isradipine (PN 200-110)是一种高效选择性的L型压力控式钙离子通道抑制剂,用于治疗高血压。 |
-
Environ Toxicol Chem, 2021, 10.1002/etc.5018
-
Cell Discov, 2020, 6(1):96
-
Drug Metab Dispos, 2015, 43(12):1934-7
|
|
S1905 |
Amlodipine
|
Amlodipine (UK-48340) 是一种长效的钙离子通道抑制剂,用于降低血压缓解胸部疼痛。 |
-
Oncogene, 2021, 40(6):1128-1146
-
ACS Infect Dis, 2020, acsinfecdis.0c00486
-
J Med Toxicol, 2020, 16(1):61-66
|
|
S1885 |
Felodipine
|
Felodipine (CGH-869) 是一种选择性L型Ca2+通道阻断剂,IC50为0.15 nM。 |
-
ACS Infect Dis, 2020, acsinfecdis.0c00486
-
Cell Discov, 2020, 6(1):96
|
|
S2481 |
Manidipine
|
Manidipine是一种二氢吡啶类钙拮抗剂,用于治疗高血压。 |
-
Antiviral Res, 2018, 150:130-136
|
|
S1748 |
Nisoldipine
|
Nisoldipine (Sular, BAY K 5552)是特定L型CaV1.2钙通道阻断剂,IC50为10 nM。 |
-
Biomed Pharmacother, 2022, 145:112432
-
Cell Mol Gastroenterol Hepatol, 2021, S2352-345X(21)00196-X
-
Cell Discov, 2020, 6(1):96
|
|
S1747 |
Nimodipine
|
Nimodipine (BAY E 9736) 是一种二氢吡啶衍生物,是钙离子通道抑制剂Nifedipine的类似物,具有降压活性。Nimodipine能减少细胞内游离Ca2+,Beclin-1及细胞自噬。 |
-
Cell Discov, 2020, 6(1):96
-
G3 (Bethesda), 2020, 4;10(5):1585-1597
-
Antiviral Res, 2016, 132:38-45
|
|
S2721 |
Nilvadipine
|
Nilvadipine (ARC029, FR34235) 是一种强效钙通道阻滞剂,IC50为0.03 nM。 |
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
Hum Cell, 2021, 10.1007/s13577-021-00639-4
-
Hum Cell, 2021, 34(6):1911-1918
|
|
S1994 |
Lacidipine
|
Lacidipine (GX-1048, GR-43659X, SN-305)是一种L-型钙离子通道抑制剂。 |
|
|
S2114 |
Dronedarone HCl
|
Dronedarone HCl (SR33589) 用于治疗阵发性和持续性房颤或房扑的患者。 |
-
Chem Res Toxicol, 2021, 10.1021/acs.chemrestox.1c00127
-
Cell Syst, 2019, 8(2):97-108
-
Nat Commun, 2016, 7:13023
|
|
S4181 |
Nicardipine HCl
|
Nicardipine HCl (RS-69216)是二氢吡啶的钙通道抑制剂,具有显著的血管扩张作用。 |
-
ACS Infect Dis, 2020, acsinfecdis.0c00486
-
Cell Discov, 2020, 6(1):96
|
|
S1808 |
Nifedipine (BAY-a-1040)
|
Nifedipine (BAY-a-1040)是一种二氢吡啶类钙离子通道阻滞剂,是有效的血管扩张剂,具有钙拮抗作用。 |
-
Oncogene, 2021, 40(6):1128-1146
-
Cell Discov, 2020, 6(1):96
-
Front Pharmacol, 2019, 10:381
|
|
S2080 |
Clevidipine Butyrate
|
Clevidipine Butyrate是一种二氢吡啶类钙离子通道抑制剂,用于降血压。 |
-
ACS Infect Dis, 2020, acsinfecdis.0c00486
|
|
S2017 |
Benidipine HCl
|
Benidipine HCl (KW-3049) 是Benidipine的盐酸盐形式,是一种二氢吡啶类的钙离子通道抑制剂。 |
-
ACS Infect Dis, 2020, acsinfecdis.0c00486
-
Cell Discov, 2020, 6(1):96
-
Life Sci, 2019, 227:74-81
|
|
S2030 |
Flunarizine 2HCl
|
Flunarizine 2HCl (KW-3149, R14950) 是一种二氢盐酸盐,抑制钙离子通道,Ki为68 nM。 |
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
Hum Cell, 2021, 10.1007/s13577-021-00639-4
-
Hum Cell, 2021, 34(6):1911-1918
|
|
S2491 |
Nitrendipine
|
Nitrendipine (Bayotensin) 是一种二氢吡啶类钙离子通道抑制剂,IC50为95 nM。 |
|
|
S3053 |
Azelnidipine
|
Azelnidipine (UR-12592)是一种二氢吡啶类钙通道阻断剂。 |
-
Cell Mol Gastroenterol Hepatol, 2021, S2352-345X(21)00196-X
-
Environ Toxicol Chem, 2021, 10.1002/etc.5018
|
|
S2573 |
Tetracaine HCl
|
Tetracaine HCl (Amethocalne)是Tetracaine的盐酸盐形式,是一种有效的局部麻醉剂和通道功能变构酶抑制剂。 |
|
|
S0000 |
Cav 2.2 blocker 1
|
Cav 2.2 blocker 1 (compound 9) 是一种 N-type calcium channel (Cav 2.2) 阻滞剂可用于治疗疼痛,其IC50值为0.001 μM。 |
|
|
S1865 |
Diltiazem HCl
|
Diltiazem (Tiazac, RG 83606) HCl 是一种Benzothiazepine衍生物,具有舒张血管的作用,由于其抑制钙离子在膜的功能。 |
-
J Cell Mol Med, 2018, 22(12):5964-5977
-
FASEB J, 2017, 31(2):625-635
|
|
S3045 |
Cinepazide maleate
|
Cinepazide maleate是cinepazide的马来酸盐形式,而cinepazide是一种血管舒张药。 |
|
|
S5255 |
Nicardipine
|
Nicardipine is a potent calcium channel blockader with marked vasodilator action. |
-
Cell Chem Biol, 2021, S2451-9456(21)00442-6
|
|
S3242 |
Loureirin B
|
Loureirin B (LB, LrB),是从Dracaena cochinchinensis中提取的类黄酮,是 PAI-1 的抑制剂,其IC50值为26.10 μM。Loureirin B 可下调TGF-β1刺激的成纤维细胞中的 p-ERK 和 p-JNK。Loureirin B 主要通过增加Pdx-1、MafA、细胞内ATP水平来促进胰岛素分泌,抑制 KATP 电流,Ca2+ 进入细胞内。 |
|
|
S8380 |
YM-58483 (BTP2)
|
YM-58483/BTP2是钙池调控钙离子进入(SOCE)的阻滞剂,参与调解不可兴奋细胞如淋巴细胞的激活。 |
-
Dev Cell, 2022, S1534-5807(21)01035-2
-
Front Pharmacol, 2021, 12:622774
-
Cell Stem Cell, 2018, 22(6):865-878
|
|
S0535 |
FK962
|
FK962是FK960的衍生物,具有抗痴呆的特性,在1-1000 nM时,显著增强高K+诱导的大鼠海马片的生长抑素释放,在1-100 nM时,也显著降低生长抑素诱导的大鼠海马神经元的Ca2+通道抑制。 |
|
|
S6657 |
2-Aminoethyl Diphenylborinate (2-APB)
|
2-Aminoethyl Diphenylborinate (2-APB)是IP3 receptor的抑制剂,可以调节IP3诱导的钙释放。2-APB还可以抑制SOC通道的活性,并且在高浓度的时候可以激活TRP通道。 |
-
Int J Biol Sci, 2021, 17(13):3672-3688
-
Int J Biol Sci, 2021, 17(13):3672-3688
-
Chem Biol Interact, 2021, 351:109756
|
|
S4626 |
Ethosuximide
|
Ethosuximide是一种琥珀酰亚胺类的抗痉挛试剂,主要用于失神发作。是钙离子通道阻滞剂。 |
-
Nature, 2018, 554(7692):317-322
|
|
S5966 |
Amlodipine maleate
|
Amlodipine (Amvaz, UK-48340) maleate 是一种长效的 calcium channel 的阻滞剂,可用于降低血压或预防胸痛。 |
|
|
S4597 |
Lercanidipine hydrochloride
|
Lercanidipine是二氢吡啶类的钙离子通道抑制剂。 |
-
J Phys Chem B, 2013, 117(23):6868-73
|
|
S4977 |
Efonidipine
|
Efonidipine (NZ-105) 是一种L型和T型钙离子通道阻滞剂,可引起血管舒张和心脏自律性降低。它还能抑制醛固酮从肾上腺分泌。 |
|
|
S5279 |
Fendiline hydrochloride
|
Fendiline hydrochloride is the hydrochloride salt form of Fendiline, which is an L-type calcium channel blocker and also a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras. |
|
|
S3845 |
Panaxadiol
|
Panaxadiol (20(R)-Panaxadiol) is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential. |
|
|
S5898 |
Efonidipine hydrochloride monoethanolate
|
Efonidipine (NZ-105) hydrochloride monoethanolate 是一种L型和T型 calcium channel 的阻滞剂,可导致血管舒张并降低心脏的自动节律性。Efonidipine hydrochloride monoethanolate 还抑制肾上腺醛固酮的分泌。 |
|
|
S3700 |
DHBP dibromide
|
DHBP (1,1'-diheptyl-4,4'-bipyridinium),一种用于电致色记忆显示剂的紫罗碱,抑制由2 mM咖啡因和2 μg/ml多熔素诱导的钙释放,IC50分别为5 μg/ml和4 μg/ml。 |
|
|
S6834 |
CM 4620
|
CM 4620 是一种 calcium-release activated calcium-channel (CRAC channel) 的抑制剂。CM4620 抑制Orai1/STIM1介导的Ca2+电流和Orai2/STIM1介导的电流,对应的IC50值分别接近120 nM和900 nM。 |
|
|
S9017 |
Columbianadin
|
Columbianadin (Zosimin, 2-Butenoic acid) 是一种来自当归的天然香豆素,已知具有多种生物活性,包括钙通道阻断活性、对各种癌细胞系的细胞毒活性、镇痛活性、肠道吸收和运输、抗炎和抗癌作用。 |
|
|
S2403 |
Tetrandrine (NSC-77037)
|
Tetrandrine (NSC-77037, Fanchinine, d-Tetrandrine)是来源于千金藤根部的一种双苯基异喹啉,一种钙离子通道抑制剂。 |
-
FASEB J, 2021, 35(5):e21502
-
Nat Commun, 2020, 27;11(1):1620
-
Ann Transl Med, 2020, 8(16):1018
|
|
S9315 |
Praeruptorin A
|
Praeruptorin A, a naturally existing pyranocumarin, is isolated from the dried root of Peucedanum praeruptorum Dunn. Praeruptorin A inhibits p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. Praeruptorin A can significantly upregulates multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction. |
|
|
S6920 |
SEA0400
|
SEA0400 是一种选择性的 Na+-Ca2+ exchanger (NCX) 的强效抑制剂,可抑制神经细胞、星形胶质细胞和小胶质细胞中Na+依赖性的Ca2+吸收,对应的IC50值分别为33 nM、5.0 nM和8.3 nM。SEA0400 可防止硝普钠 (SNP) 提高 ERK 和 p38 MAPK 的磷酸化和通过细胞外Ca2+依赖的方式增强reactive oxygen species (ROS) 的产生。 |
|
|
S3931 |
Ginsenoside Rd
|
Ginsenoside Rd (Panaxoside Rd, Sanchinoside Rd), a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively. |
-
J Ethnopharmacol, 2021, S0378-8741(21)00169-0
|
|
S5514 |
Lanthanum(III) chloride heptahydrate
|
Lanthanum(III) chloride is the inorganic compound used in biochemical research to block the activity of divalent cation channels, mainly calcium channels. |
-
J Surg Res, 2021, 263:236-244
|
|
S3766 |
Tanshinone IIA sulfonate sodium
|
Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA isolated as the main pharmacologically active natural compound from a traditional Chinese herbal medicine, the dried root of Salvia miltiorrhiza Bunge known as Danshen. Sodium tanshinone IIA sulfonate (STS) is a potent negative allosteric modulator of the human purinergic receptor P2X7. Sodium tanshinone IIA sulfonate (STS) inhibits the activity of CYP3A4 and store-operated Ca2+ entry (SOCE) through store-operated Ca2+ channels (SOCC) via downregulating the expression of transient receptor potential canonical proteins (TRPC). |
|
|
S4084 |
Lomerizine 2HCl
|
Lomerizine dihydrochloride (KB-2796) 是一种相对较新的L-和T-型钙通道阻滞剂,用于治疗偏头痛。 |
|
|
S4648 |
Dantrolene sodium hemiheptahydrate
|
Dantrolene sodium hemiheptahydrate (Dantrium) 是一种骨骼肌松弛药,通过干扰肌纤维中的兴奋-收缩偶联起作用。 |
-
Cardiovasc Res, 2021, 117(4):1091-1102
-
Oxid Med Cell Longev, 2021, 2021:8810698
|
|
S3682 |
Ethyl 3-Aminobenzoate methanesulfonate
|
Ethyl 3-Aminobenzoate (Ethyl m-Aminobenzoate, NSC 93790, Tricaine) 可通过voltage-dependent Na+-channels阻止动作电位的产生,常用于鱼类的麻醉、镇静和安乐死。 |
|
|
S9400 |
Rhynchophylline
|
Rhynchophylline (Mitrinermine), an active component isolated from species of the genus Uncaria, acts as a calcium channel blocker and is widely used in traditional Chinese medicine mainly for treating ailments of central nervous and cardiovascular systems, such as lightheadedness, convulsions, numbness, and hypertension. |
|
|
S3674 |
Levamlodipine
|
Levamlodipine (S-amlodipine) is a pharmacologically active enantiomer of amlodipine which belongs to the dihydropyridine group of calcium channel blocker. It acts on the L-type of calcium channels and its treatment results in vasodilation and a fall in blood pressure. |
-
Oncogene, 2021, 40(6):1128-1146
|
|
S3883 |
Protopine
|
Protopine (Corydinine, Fumarine, Biflorine, Macleyine), an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities. |
|
|
S5567 |
Trimethadione
|
Trimethadione is an oxazolidinedione anticonvulsant and often used to treat epileptic conditions that are resistant to other treatments. |
|
|
S9566 |
Bepridil hydrochloride
|
Bepridil hydrochloride是一种抗心绞痛的药物,是钙离子通道(calcium channel)阻滞剂。它能阻止多种其他离子通道,包括钠离子和钾离子通道。 |
|
|
S6847 |
ML-9 HCl
|
ML-9 HCl (ML-9 hydrochloride) 是一种有效的选择性的 Akt kinase、myosin light chain kinase (MLCK) 和 stromal interaction molecule 1 (STIM1)。ML-9 HCl 也是 Ca2+-permeable channels 的有效抑制剂。ML-9 HCl 是一种靶向自噬和细胞死亡的亲溶酶体剂。 |
-
J Mol Endocrinol, 2019, 63(3):199-213
|
|
S0452 |
NP118809
|
NP118809(39-1B4)是一种有效的N型钙通道(N-type calcium channel)阻滞剂,IC50为0.11 μM,对L型钙通道(L-type calcium channel)的抑制作用也较弱,IC50为12.2 μM。 |
|
|
S0016 |
SN-6
|
SN-6 是一种选择性的 Na+/Ca2+ exchanger (NCX) 抑制剂。SN-6 可抑制NCX1、NCX2和NCX3,对应的IC50值分别为2.9 μM、16 μM和8.6 μM。SN-6 可消除 acetylcholine (ACh) 诱导的血管舒张。 |
|
|
S6473 |
Pinaverium bromide
|
Pinaverium bromide (Icosapentaenoic acid)是calcium channel阻滞剂,适用于治疗功能性胃肠病。 |
|
|
S4727 |
Cinnarizine
|
Cinnarizine (Stugeron, Dimitronal, Stutgin, Cinarizine)是piperazine的药物衍生物,是抗组胺剂和钙离子通道阻滞剂。 |
|
|
S9842 |
MCU-i4
|
MCU-i4 是 mitochondrial calcium uniporter (MCU) 复合物的负调节剂,可直接结合 MICU1 中的特定裂缝并减少线粒体 Ca2+ 流入。 |
|
|
S2050 |
Strontium Ranelate
|
Strontium Ranelate 是Ranelic acid的锶(II)盐,用于(-)-Desmethoxyverapamil结合到钙离子通道,IC50为0.5 mM。 |
|
|
S7924 |
Bay K 8644
|
Bay K 8644是一种高选择性的L型钙离子通道激动剂,EC50为17.3 nM。 |
-
ACS Nano, 2021, 10.1021/acsnano.1c03517
-
Cell Biol Toxicol, 2021, 10.1007/s10565-021-09615-y
-
Journal of Advanced Research, 2020, 10.1016/j.jare.2020.10.005
|
|
S4209 |
Chlorocresol
|
Chlorocresol 是ryanodine receptor激活剂。 |
|
|
E0777New |
Z944
|
Z944是一种高度选择性的T型钙通道拮抗剂,对hCaV3.1、hCaV3.2和hCaV3.3的IC50分别为50、160、110 nM。 |
|
|
E0945New |
BIA
|
BIA (TMBIM6 antagonist BIA)是一个潜在的TMBIM6拮抗剂,可以阻断TMBIM6和mTORC2的相互作用,最终阻断AKT的激活和癌症进展。 |
|
|
S4931 |
Propiverine hydrochloride
|
Propiverine是一种抗胆碱能药物,用于治疗膀胱过度活动症和尿失禁。 |
|
|
S0870 |
Barnidipine
|
Barnidipine (Libradin, Mepirodipine, Vasexten, YM-09730-5, Cyress, Hypoca, Oldeca) 是一种降压药,属于dihydropyridine (DHP)组的calcium 拮抗剂 (CaA),对[3H]nitrendipine 结合位点的Ki值为0.21 nM。 |
|
|
S3809 |
Imperatorin
|
Imperatorin (Ammidin, Marmelosin, Pentosalen, 8-Isoamylenoxypsoralen), a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle. |
-
Front Cell Dev Biol, 2020, 8:592433
-
Adv Sci (Weinh), 2020, 7(16):2000925
-
Theriogenology, 2019, 10.1016/j.theriogenology
|
|
S2436 |
Pranidipine
|
Pranidipine (Acalas, OPC 13340)是一种新型的1,4-二氢吡啶 calcium channel 阻滞剂。Pranidipine可以增强cyclic GMP依赖性一氧化氮诱导的大鼠主动脉舒张。 |
|
|
S5861 |
Lercanidipine
|
Lercanidipine是一种对血管具有特异性的钙离子通道拮抗剂,可用于治疗发性高血压。 |
|
|
E0137New |
GV-58
|
GV-58 是一种新型的选择性 N 型和 P/Q 型 Ca2+ 通道激动剂,IC50 分别为 7.21 μM 和 8.81 μM。 |
|
|
S5191 |
Cinacalcet
|
Cinacalcet (AMG073, Sensipar, Cin) 是一种口服活性的 receptors for calcium (CaR) 的变构激动剂,可增加CaR对Ca的敏感性。 |
-
Int J Mol Sci, 2022, 23(8)4323
|
|
S9151 |
Praeruptorin E
|
Praeruptorin E, isolated from Peucedanum praeruptorum Dunn., is a cardiotonic agent with selective cardiac calcium channel agonistic effect. |
|
|
E0936New |
IGS-1.76
|
IGS-1.76是一种蛋白-蛋白相互作用(protein-protein interaction, PPI)抑制剂,具有药物样特性,对人类神经钙传感蛋白1(human neuronal calcium sensor 1, hNCS-1)具有显著的亲和力,并有效地调节hNCS-1和鸟嘌呤交换因子Ric8a的相互作用。 |
|
|
S2535 |
Econazole nitrate
|
Econazole Nitrate (NSC 243115) 是一种咪唑类抗真菌药物。 |
-
Biomol Ther (Seoul), 2020, 25
|
|
S0713 |
S107 hydrochloride
|
S107 hydrochloride 是一种 RyR2 (type 2 ryanodine receptor)/FKBP12.6 (FK506 binding protein 12.6) complex 的特异性稳定剂,会影响 Ca2+ 信号传导。 |
|
|
S3236 |
Mesaconitine
|
Mesaconitine 是Aconiti tuber附子块茎中的附子生物碱之一,通过从细胞外空间流入Ca2+来增加内皮细胞中的[Ca2+]i水平。 |
|
|
S0973 |
Wilforgine
|
Wilforgine 是 Tripterygium wilfordii Hook. F.中主要的生物活性倍半萜生物碱之一,可在M. separata larvae的肌肉中诱导显微结构和超微结构变化,其发挥作用的位置是肌肉系统中的 calcium receptors or channels。 |
|
|
S2415 |
Astragaloside A
|
Astragaloside A是从黄芪中分离的一种纯化的皂苷,广泛应用于治疗心血管疾病。 |
-
Sci Rep, 2022, 12(1):7
-
Carcinogenesis, 2020, 41(7):993-1004
-
J Med Virol, 2019, 91(8):1440-1447
|
|
S3191 |
Azumolene
|
Azumolene(EU4093 free base)是一种等效的丹曲林(dantrolene)类似物,是一种兰尼碱受体 (ryanodine receptor, RyR) 调节剂,可抑制钙释放。 |
|
|
S4353 |
Terfenadine
|
Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9. |
|
|
S2446 |
Levosimendan
|
Levosimendan 是一种钙增敏剂,通过与cardiac troponin C (cTnC)结合而发挥作用,这种作用具有钙依赖性。 |
-
Antiviral Res, 2017, 146:76-85
|
|
S1911 |
Disodium Cromoglycate
|
Disodium Cromoglycate (FPL 670, Cromolyn) 是一种抗过敏药,IC50为39 μg/mL。 |
|
|
S6994 |
TD-165
|
TD-165 是基于 PROTAC 技术的 CRBN 降解剂。 TD-165 包括一个 CRBN 配体结合基团,一个 linker 和一个 VHL 结合基团。 |
|
|
S5478 |
Dantrolene sodium
|
Dantrolene sodium acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. |
-
Transl Stroke Res, 2022, 10.1007/s12975-022-01021-8
-
Oxid Med Cell Longev, 2021, 2021:8810698
-
Sci Rep, 2019, 9(1):3487
|
|
S1573 |
Fasudil (HA-1077) HCl
|
Fasudil (HA-1077, AT-877)是一种有效的、具有选择性的Rho抑制剂(ROCK2, Ki=0.33 μM),同时对PKA、PKG、PKC和MLCK也具有抑制活性,Ki值分别为1.6 μM、1.6 μM、3.3 μM、36 μM。Fasudil 也是calcium channel的阻滞剂。 |
- Aging Cell, 2022, e13587
- Cell Death Dis, 2022, 13(2):138
- iScience, 2022, 25(6):104398
|
|
S1356 |
Levetiracetam (UCB-L059)
|
Levetiracetam (UCB-L059, SIB-S1) 是一种抗癫痫化合物。Levetiracetam (UCB-L059, SIB-S1) 是 muscarinic acetylcholine receptors (mAChR) 的激动剂并能调节突触前P/Q型压敏钙离子通道 calcium (Ca2+) channel。 |
- Anticancer Res, 2021, 41(2):687-697
- PLoS One, 2019, 14(2):e0211644
- Sci Rep, 2016, 6:25705
|
|
S1813 |
Amlodipine Besylate
|
Amlodipine Besylate是一种长效的钙离子通道抑制剂,IC50为1.9 nM。 |
- Cell Discov, 2020, 6(1):96
- Oncogene, 2019, 38(1):120-139
|
|
S1293 |
Cilnidipine (FRC-8653)
|
Cilnidipine (FRC-8653) 是一种L型和N型钙离子通道抑制剂,用来治疗高血压。 |
- ACS Infect Dis, 2020, acsinfecdis.0c00486
- Cell Discov, 2020, 6(1):96
- Res Sq, 2020, rs.3.rs-48659
|
|
S1811 |
Amiloride (MK-870) HCl
|
Amiloride (MK-870)是一种选择性的T-type calcium channel阻滞剂,epithelial sodium channel(ENaC)阻滞剂,urokinase plasminogen activator (uPA)抑制剂,Ki=7 μM。 |
- Mol Ther Methods Clin Dev, 2022, 24:11-19
- Adv Sci (Weinh), 2021, 8(13):2100962
- Theranostics, 2021, 11(5):2364-2380
|
|
E0778New |
o-3M3FBS
|
O-3M3FBS是m-3M3FBS的阴性对照,以独立于PLC的机制及拮抗的方式抑制内向和外向电流,可逆地抑制延迟整流K+通道,以与m-3M3FBS竞争的形式增加[Ca2+](i)。 |
|
|
E0826New |
Levamlodipine Besylate
|
Levamlodipine Besylate是一种强大的二氢吡啶钙通道(dihydropyridine calcium channel)阻滞剂,具有血管舒张特性,用于高血压和心绞痛的治疗。 |
|
|
S1425 |
Ranolazine 2HCl
|
Ranolazine 2HCl (RS-43285)是一种钙离子通过 sodium/calcium channal摄取的抑制剂抗心绞痛药物,用于治疗慢性心绞痛。 |
- Front Pharmacol, 2019, 10:1367
|
|
S4202 |
Verapamil (CP-16533-1) HCl
|
Verapamil HCl (CP-16533-1)是L-型钙通道抑制剂,是第四类抗心律失常的药剂。Verapamil 可抑制 permeability-glycoprotein (P-gp) 和 CYP3A4。 |
- EMBO Mol Med, 2022, 14(2):e14903
- Cell Rep, 2022, 38(10):110468
- ACS Nano, 2021, 10.1021/acsnano.1c03517
|
|
S2482 |
Manidipine 2HCl
|
Manidipine 2HCl (CV-4093) 是Manidipine的盐酸盐形式,是钙通道阻断剂,IC50为2.6 nM,临床上常用于抗高血压。Phase 4。 |
- Environ Toxicol Chem, 2021, 10.1002/etc.5018
|
|
S1799 |
Ranolazine
|
Ranolazine (CVT 303, RS 43285-003)是一种钙离子通过 sodium/calcium channal摄取的抑制剂抗心绞痛药物,用于治疗慢性心绞痛。 |
|
|
S1662 |
Isradipine
|
Isradipine (PN 200-110)是一种高效选择性的L型压力控式钙离子通道抑制剂,用于治疗高血压。 |
- Environ Toxicol Chem, 2021, 10.1002/etc.5018
- Cell Discov, 2020, 6(1):96
- Drug Metab Dispos, 2015, 43(12):1934-7
|
|
S1905 |
Amlodipine
|
Amlodipine (UK-48340) 是一种长效的钙离子通道抑制剂,用于降低血压缓解胸部疼痛。 |
- Oncogene, 2021, 40(6):1128-1146
- ACS Infect Dis, 2020, acsinfecdis.0c00486
- J Med Toxicol, 2020, 16(1):61-66
|
|
S1885 |
Felodipine
|
Felodipine (CGH-869) 是一种选择性L型Ca2+通道阻断剂,IC50为0.15 nM。 |
- ACS Infect Dis, 2020, acsinfecdis.0c00486
- Cell Discov, 2020, 6(1):96
|
|
S2481 |
Manidipine
|
Manidipine是一种二氢吡啶类钙拮抗剂,用于治疗高血压。 |
- Antiviral Res, 2018, 150:130-136
|
|
S1748 |
Nisoldipine
|
Nisoldipine (Sular, BAY K 5552)是特定L型CaV1.2钙通道阻断剂,IC50为10 nM。 |
- Biomed Pharmacother, 2022, 145:112432
- Cell Mol Gastroenterol Hepatol, 2021, S2352-345X(21)00196-X
- Cell Discov, 2020, 6(1):96
|
|
S1747 |
Nimodipine
|
Nimodipine (BAY E 9736) 是一种二氢吡啶衍生物,是钙离子通道抑制剂Nifedipine的类似物,具有降压活性。Nimodipine能减少细胞内游离Ca2+,Beclin-1及细胞自噬。 |
- Cell Discov, 2020, 6(1):96
- G3 (Bethesda), 2020, 4;10(5):1585-1597
- Antiviral Res, 2016, 132:38-45
|
|
S2721 |
Nilvadipine
|
Nilvadipine (ARC029, FR34235) 是一种强效钙通道阻滞剂,IC50为0.03 nM。 |
- Hum Cell, 2022, 10.1007/s13577-022-00671-y
- Hum Cell, 2021, 10.1007/s13577-021-00639-4
- Hum Cell, 2021, 34(6):1911-1918
|
|
S1994 |
Lacidipine
|
Lacidipine (GX-1048, GR-43659X, SN-305)是一种L-型钙离子通道抑制剂。 |
|
|
S2114 |
Dronedarone HCl
|
Dronedarone HCl (SR33589) 用于治疗阵发性和持续性房颤或房扑的患者。 |
- Chem Res Toxicol, 2021, 10.1021/acs.chemrestox.1c00127
- Cell Syst, 2019, 8(2):97-108
- Nat Commun, 2016, 7:13023
|
|
S4181 |
Nicardipine HCl
|
Nicardipine HCl (RS-69216)是二氢吡啶的钙通道抑制剂,具有显著的血管扩张作用。 |
- ACS Infect Dis, 2020, acsinfecdis.0c00486
- Cell Discov, 2020, 6(1):96
|
|
S1808 |
Nifedipine (BAY-a-1040)
|
Nifedipine (BAY-a-1040)是一种二氢吡啶类钙离子通道阻滞剂,是有效的血管扩张剂,具有钙拮抗作用。 |
- Oncogene, 2021, 40(6):1128-1146
- Cell Discov, 2020, 6(1):96
- Front Pharmacol, 2019, 10:381
|
|
S2080 |
Clevidipine Butyrate
|
Clevidipine Butyrate是一种二氢吡啶类钙离子通道抑制剂,用于降血压。 |
- ACS Infect Dis, 2020, acsinfecdis.0c00486
|
|
S2017 |
Benidipine HCl
|
Benidipine HCl (KW-3049) 是Benidipine的盐酸盐形式,是一种二氢吡啶类的钙离子通道抑制剂。 |
- ACS Infect Dis, 2020, acsinfecdis.0c00486
- Cell Discov, 2020, 6(1):96
- Life Sci, 2019, 227:74-81
|
|
S2030 |
Flunarizine 2HCl
|
Flunarizine 2HCl (KW-3149, R14950) 是一种二氢盐酸盐,抑制钙离子通道,Ki为68 nM。 |
- Hum Cell, 2022, 10.1007/s13577-022-00671-y
- Hum Cell, 2021, 10.1007/s13577-021-00639-4
- Hum Cell, 2021, 34(6):1911-1918
|
|
S2491 |
Nitrendipine
|
Nitrendipine (Bayotensin) 是一种二氢吡啶类钙离子通道抑制剂,IC50为95 nM。 |
|
|
S3053 |
Azelnidipine
|
Azelnidipine (UR-12592)是一种二氢吡啶类钙通道阻断剂。 |
- Cell Mol Gastroenterol Hepatol, 2021, S2352-345X(21)00196-X
- Environ Toxicol Chem, 2021, 10.1002/etc.5018
|
|
S2573 |
Tetracaine HCl
|
Tetracaine HCl (Amethocalne)是Tetracaine的盐酸盐形式,是一种有效的局部麻醉剂和通道功能变构酶抑制剂。 |
|
|
S0000 |
Cav 2.2 blocker 1
|
Cav 2.2 blocker 1 (compound 9) 是一种 N-type calcium channel (Cav 2.2) 阻滞剂可用于治疗疼痛,其IC50值为0.001 μM。 |
|
|
S1865 |
Diltiazem HCl
|
Diltiazem (Tiazac, RG 83606) HCl 是一种Benzothiazepine衍生物,具有舒张血管的作用,由于其抑制钙离子在膜的功能。 |
- J Cell Mol Med, 2018, 22(12):5964-5977
- FASEB J, 2017, 31(2):625-635
|
|
S3045 |
Cinepazide maleate
|
Cinepazide maleate是cinepazide的马来酸盐形式,而cinepazide是一种血管舒张药。 |
|
|
S5255 |
Nicardipine
|
Nicardipine is a potent calcium channel blockader with marked vasodilator action. |
- Cell Chem Biol, 2021, S2451-9456(21)00442-6
|
|
S3242 |
Loureirin B
|
Loureirin B (LB, LrB),是从Dracaena cochinchinensis中提取的类黄酮,是 PAI-1 的抑制剂,其IC50值为26.10 μM。Loureirin B 可下调TGF-β1刺激的成纤维细胞中的 p-ERK 和 p-JNK。Loureirin B 主要通过增加Pdx-1、MafA、细胞内ATP水平来促进胰岛素分泌,抑制 KATP 电流,Ca2+ 进入细胞内。 |
|
|
S8380 |
YM-58483 (BTP2)
|
YM-58483/BTP2是钙池调控钙离子进入(SOCE)的阻滞剂,参与调解不可兴奋细胞如淋巴细胞的激活。 |
- Dev Cell, 2022, S1534-5807(21)01035-2
- Front Pharmacol, 2021, 12:622774
- Cell Stem Cell, 2018, 22(6):865-878
|
|
S0535 |
FK962
|
FK962是FK960的衍生物,具有抗痴呆的特性,在1-1000 nM时,显著增强高K+诱导的大鼠海马片的生长抑素释放,在1-100 nM时,也显著降低生长抑素诱导的大鼠海马神经元的Ca2+通道抑制。 |
|
|
S6657 |
2-Aminoethyl Diphenylborinate (2-APB)
|
2-Aminoethyl Diphenylborinate (2-APB)是IP3 receptor的抑制剂,可以调节IP3诱导的钙释放。2-APB还可以抑制SOC通道的活性,并且在高浓度的时候可以激活TRP通道。 |
- Int J Biol Sci, 2021, 17(13):3672-3688
- Int J Biol Sci, 2021, 17(13):3672-3688
- Chem Biol Interact, 2021, 351:109756
|
|
S4626 |
Ethosuximide
|
Ethosuximide是一种琥珀酰亚胺类的抗痉挛试剂,主要用于失神发作。是钙离子通道阻滞剂。 |
- Nature, 2018, 554(7692):317-322
|
|
S5966 |
Amlodipine maleate
|
Amlodipine (Amvaz, UK-48340) maleate 是一种长效的 calcium channel 的阻滞剂,可用于降低血压或预防胸痛。 |
|
|
S4597 |
Lercanidipine hydrochloride
|
Lercanidipine是二氢吡啶类的钙离子通道抑制剂。 |
- J Phys Chem B, 2013, 117(23):6868-73
|
|
S4977 |
Efonidipine
|
Efonidipine (NZ-105) 是一种L型和T型钙离子通道阻滞剂,可引起血管舒张和心脏自律性降低。它还能抑制醛固酮从肾上腺分泌。 |
|
|
S5279 |
Fendiline hydrochloride
|
Fendiline hydrochloride is the hydrochloride salt form of Fendiline, which is an L-type calcium channel blocker and also a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras. |
|
|
S3845 |
Panaxadiol
|
Panaxadiol (20(R)-Panaxadiol) is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential. |
|
|
S5898 |
Efonidipine hydrochloride monoethanolate
|
Efonidipine (NZ-105) hydrochloride monoethanolate 是一种L型和T型 calcium channel 的阻滞剂,可导致血管舒张并降低心脏的自动节律性。Efonidipine hydrochloride monoethanolate 还抑制肾上腺醛固酮的分泌。 |
|
|
S3700 |
DHBP dibromide
|
DHBP (1,1'-diheptyl-4,4'-bipyridinium),一种用于电致色记忆显示剂的紫罗碱,抑制由2 mM咖啡因和2 μg/ml多熔素诱导的钙释放,IC50分别为5 μg/ml和4 μg/ml。 |
|
|
S6834 |
CM 4620
|
CM 4620 是一种 calcium-release activated calcium-channel (CRAC channel) 的抑制剂。CM4620 抑制Orai1/STIM1介导的Ca2+电流和Orai2/STIM1介导的电流,对应的IC50值分别接近120 nM和900 nM。 |
|
|
S9017 |
Columbianadin
|
Columbianadin (Zosimin, 2-Butenoic acid) 是一种来自当归的天然香豆素,已知具有多种生物活性,包括钙通道阻断活性、对各种癌细胞系的细胞毒活性、镇痛活性、肠道吸收和运输、抗炎和抗癌作用。 |
|
|
S2403 |
Tetrandrine (NSC-77037)
|
Tetrandrine (NSC-77037, Fanchinine, d-Tetrandrine)是来源于千金藤根部的一种双苯基异喹啉,一种钙离子通道抑制剂。 |
- FASEB J, 2021, 35(5):e21502
- Nat Commun, 2020, 27;11(1):1620
- Ann Transl Med, 2020, 8(16):1018
|
|
S9315 |
Praeruptorin A
|
Praeruptorin A, a naturally existing pyranocumarin, is isolated from the dried root of Peucedanum praeruptorum Dunn. Praeruptorin A inhibits p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. Praeruptorin A can significantly upregulates multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction. |
|
|
S6920 |
SEA0400
|
SEA0400 是一种选择性的 Na+-Ca2+ exchanger (NCX) 的强效抑制剂,可抑制神经细胞、星形胶质细胞和小胶质细胞中Na+依赖性的Ca2+吸收,对应的IC50值分别为33 nM、5.0 nM和8.3 nM。SEA0400 可防止硝普钠 (SNP) 提高 ERK 和 p38 MAPK 的磷酸化和通过细胞外Ca2+依赖的方式增强reactive oxygen species (ROS) 的产生。 |
|
|
S3931 |
Ginsenoside Rd
|
Ginsenoside Rd (Panaxoside Rd, Sanchinoside Rd), a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively. |
- J Ethnopharmacol, 2021, S0378-8741(21)00169-0
|
|
S5514 |
Lanthanum(III) chloride heptahydrate
|
Lanthanum(III) chloride is the inorganic compound used in biochemical research to block the activity of divalent cation channels, mainly calcium channels. |
- J Surg Res, 2021, 263:236-244
|
|
S3766 |
Tanshinone IIA sulfonate sodium
|
Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA isolated as the main pharmacologically active natural compound from a traditional Chinese herbal medicine, the dried root of Salvia miltiorrhiza Bunge known as Danshen. Sodium tanshinone IIA sulfonate (STS) is a potent negative allosteric modulator of the human purinergic receptor P2X7. Sodium tanshinone IIA sulfonate (STS) inhibits the activity of CYP3A4 and store-operated Ca2+ entry (SOCE) through store-operated Ca2+ channels (SOCC) via downregulating the expression of transient receptor potential canonical proteins (TRPC). |
|
|
S4084 |
Lomerizine 2HCl
|
Lomerizine dihydrochloride (KB-2796) 是一种相对较新的L-和T-型钙通道阻滞剂,用于治疗偏头痛。 |
|
|
S4648 |
Dantrolene sodium hemiheptahydrate
|
Dantrolene sodium hemiheptahydrate (Dantrium) 是一种骨骼肌松弛药,通过干扰肌纤维中的兴奋-收缩偶联起作用。 |
- Cardiovasc Res, 2021, 117(4):1091-1102
- Oxid Med Cell Longev, 2021, 2021:8810698
|
|
S3682 |
Ethyl 3-Aminobenzoate methanesulfonate
|
Ethyl 3-Aminobenzoate (Ethyl m-Aminobenzoate, NSC 93790, Tricaine) 可通过voltage-dependent Na+-channels阻止动作电位的产生,常用于鱼类的麻醉、镇静和安乐死。 |
|
|
S9400 |
Rhynchophylline
|
Rhynchophylline (Mitrinermine), an active component isolated from species of the genus Uncaria, acts as a calcium channel blocker and is widely used in traditional Chinese medicine mainly for treating ailments of central nervous and cardiovascular systems, such as lightheadedness, convulsions, numbness, and hypertension. |
|
|
S3674 |
Levamlodipine
|
Levamlodipine (S-amlodipine) is a pharmacologically active enantiomer of amlodipine which belongs to the dihydropyridine group of calcium channel blocker. It acts on the L-type of calcium channels and its treatment results in vasodilation and a fall in blood pressure. |
- Oncogene, 2021, 40(6):1128-1146
|
|
S3883 |
Protopine
|
Protopine (Corydinine, Fumarine, Biflorine, Macleyine), an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities. |
|
|
S5567 |
Trimethadione
|
Trimethadione is an oxazolidinedione anticonvulsant and often used to treat epileptic conditions that are resistant to other treatments. |
|
|
S9566 |
Bepridil hydrochloride
|
Bepridil hydrochloride是一种抗心绞痛的药物,是钙离子通道(calcium channel)阻滞剂。它能阻止多种其他离子通道,包括钠离子和钾离子通道。 |
|
|
S6847 |
ML-9 HCl
|
ML-9 HCl (ML-9 hydrochloride) 是一种有效的选择性的 Akt kinase、myosin light chain kinase (MLCK) 和 stromal interaction molecule 1 (STIM1)。ML-9 HCl 也是 Ca2+-permeable channels 的有效抑制剂。ML-9 HCl 是一种靶向自噬和细胞死亡的亲溶酶体剂。 |
- J Mol Endocrinol, 2019, 63(3):199-213
|
|
S0452 |
NP118809
|
NP118809(39-1B4)是一种有效的N型钙通道(N-type calcium channel)阻滞剂,IC50为0.11 μM,对L型钙通道(L-type calcium channel)的抑制作用也较弱,IC50为12.2 μM。 |
|
|
S0016 |
SN-6
|
SN-6 是一种选择性的 Na+/Ca2+ exchanger (NCX) 抑制剂。SN-6 可抑制NCX1、NCX2和NCX3,对应的IC50值分别为2.9 μM、16 μM和8.6 μM。SN-6 可消除 acetylcholine (ACh) 诱导的血管舒张。 |
|
|
S6473 |
Pinaverium bromide
|
Pinaverium bromide (Icosapentaenoic acid)是calcium channel阻滞剂,适用于治疗功能性胃肠病。 |
|
|
S4727 |
Cinnarizine
|
Cinnarizine (Stugeron, Dimitronal, Stutgin, Cinarizine)是piperazine的药物衍生物,是抗组胺剂和钙离子通道阻滞剂。 |
|
|
S9842 |
MCU-i4
|
MCU-i4 是 mitochondrial calcium uniporter (MCU) 复合物的负调节剂,可直接结合 MICU1 中的特定裂缝并减少线粒体 Ca2+ 流入。 |
|
|