Z-VAD-FMK

For research use only. Not for use in humans.

目录号:S7023 别名: Z-VAD(OMe)-FMK

Z-VAD-FMK Chemical Structure

CAS No. 187389-52-2

Z-VAD-FMK (Z-VAD(OMe)-FMK)是一种细胞渗透性的,不可逆泛caspase抑制剂,在THP.1 和 Jurkat T细胞中阻断细胞凋亡的所有特性。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 6953.84 现货
RMB 962.65 现货
RMB 3841.92 现货
RMB 9746.63 现货

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客户使用Selleck生产的Z-VAD-FMK发表文献661篇:

产品安全说明书

Caspase抑制剂选择性比较

生物活性

产品描述 Z-VAD-FMK (Z-VAD(OMe)-FMK)是一种细胞渗透性的,不可逆泛caspase抑制剂,在THP.1 和 Jurkat T细胞中阻断细胞凋亡的所有特性。
特性 Z-VAD-FMK是研究细胞凋亡的一种关键化合物。
靶点
Pan-caspase [1]
(THP.1, Jurkat T-cells)
体外研究

Z-VAD-FMK(10 mM)作用于THP.1细胞,抑制细胞凋亡。Z-VAD-FMK(10 μM)作用于THP.1细胞裂解液,抑制PARP蛋白酶活性的激活。Z-VAD-FMK(10 mM)作用于完整THP.1和 Jurkat细胞,抑制CPP32加工。[1]Z-VAD-FMK(50 μM)与Camptothecin共处理HL60细胞,废除Camptothecin处理的细胞凋亡形态。Z-VAD-FMK(50 μM)作用于HL60细胞,抑制Camptothecin诱导的DNA分裂。[2]Z-VAD-FMK (50 μM)作用于S2细胞,提高转染细胞的生存百分数从26%提高到63%。[3]Z-VAD-FMK(>100 μM)作用于人类嗜中性粒细胞,增强TNFα-诱导的中性粒细胞凋亡,较低浓度(1-30 μM)时完全抑制TNFα刺激的细胞凋亡。[4]Z-VAD-FMK (10 mM) 作用于早期角膜基质细胞,抑制细胞凋亡。[5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
U937 MoSzRZBweHSxc3nzJGF{e2G7 MVS1NO69VQ>? M2TVSVQ5cA>? Mkm5doVlfWOnczDj[YxtKGSnYYToJINifXOnZDDifUBUU0lvSVmgeJJm[XSvZX70xsA> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh{NEC0N{c,OjV6MkSwOFM9N2F-
HL-60 M3jkTmFxd3C2b4Ppd{BCe3OjeR?= MW[1NO69VQ>? NY\QVZZRPDiq M4Pzc5Jm\HWlZYOgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhW0uLLVnJJJRz\WG2bXXueOKh NYTBUlhlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4NlQxPDNpPkK1PFI1ODR|PD;hQi=>
DTK-SME MVnBdI9xfG:|aYOgRZN{[Xl? MkPzOVDPxE1? NV7LSXV1Omh? MVnEUXNQ MoHtdIFzfGmjbHz5JIlvcGmkaYTzJJRp\SCjcH;weI9{cXNiaX7keYNm\CCkeTDieZBqfmGlYXnu[S=> NUO0WIFVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4OFM5QTdpPkK1PFQ{QDl5PD;hQi=>
HCT116  M2\LPWFxd3C2b4Ppd{BCe3OjeR?= MlToOVDPxE1? M4G0VFJp NIPVTlVqdmirYnn0d{B1cGViY3XscEBl\WG2aDDpcoR2[2WmIHL5JGRFXlB? NWjiRYFkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4Olg5OThpPkK1PFY5QDF6PD;hQi=>
SGN M2KxT2Fxd3C2b4Ppd{BCe3OjeR?= NH[2bpgzOG2P NYDCWnRVPDiq MWjoZZMhdm9iaX7mcJVmdmOnIH;uJGFKTixiY3HsdIFqdiCneIDy[ZN{cW:wIH;yJINmdGxiYYDvdJRwe2m| MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh5NE[zN{c,OjV6N{S2N|M9N2F-
A549/V16 Ml3NRZBweHSxc3nzJGF{e2G7 NVewcpI6PTEQvF2= NIXGSWUycA>? NYHaT4FEemWycnXzd4V{KFSJL2TNMYlv\HWlZXSgZZBweHSxc3nz MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl2NkCzN{c,OjV7NE[wN|M9N2F-
U1 MX\LbY5ie2ViQYPzZZk> NFvTNVgyODEQvF2= MnLQNog> NGj5T|NqdmirYnn0d{Bk[XOyYYPlMVM> Mke1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7OEC5OFIoRjJ3OUiwPVQzRC:jPh?=
ACH-2 MUDBdI9xfG:|aYOgRZN{[Xl? NVXpdnJpOC1{MEFOwG0> MnXtNog> MWHy[YR2[2W|IHTyeYcucW6mdXPl[EBieG:ydH;zbZMh[W6mIIP1ZpNmeXWnboSgTGlXNTFicnXwcIlk[XSrb36gbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= MnrDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7OEC5OFIoRjJ3OUiwPVQzRC:jPh?=
U1 M3ruTWFxd3C2b4Ppd{BCe3OjeR?= M3jzSFAuOTByzszN MWeybC=> NHe3XGhz\WS3Y3XzJIRzfWdvaX7keYNm\CCjcH;weI9{cXNiYX7kJJN2[nOncYXlcpQhUEmYLUGgdoVxdGmlYYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> MmXmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7OEC5OFIoRjJ3OUiwPVQzRC:jPh?=
HUVEC-2c M2XtPWFxd3C2b4Ppd{BCe3OjeR?= MoHWOVDPxE1? MYW2bC=> MXvk[YNz\WG|ZXSgeIhmKG:6LVzEUE1qdmS3Y3XkJIF2fG:yaHHnfS=> NYn0VmtZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wNlE4OjlpPkK2NFIyPzJ7PD;hQi=>
SP2/0 NYO5OIZpSXCxcITvd4l{KEG|c3H5 NGi1enUyODEQvF2= NFu4bIkycA>? MWnEUXNQ MkOyZoxw[2u|IITo[UBieG:ydH;zbZMhd2ZiU2CyM|Ah[2WubIO= NYn4Z3NDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wO|Q4OzJpPkK2NFc1PzN{PD;hQi=>
CEF MV\LbY5ie2ViQYPzZZk> M2jKOVAtOzNuNkesNVAx|ryP MVmxOY1qdg>? NVXKUGtt\G:5bj3y[Yd2dGG2ZYOgVHIh\W68eX3lJIFkfGm4aYT5JJRwKDRy78{FJIF1KDFyMN88US=> MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjFyMkOzPUc,OjZzMEKzN|k9N2F-
BEL-7402 Mn7ORZBweHSxc3nzJGF{e2G7 MkTyNlDPxE1? NIjucIUycA>? MYrheJRmdnWjdHXkJJRp\SCjcH;weI91cWNiaX7keYN1cW:wIH;mJGlKUS1zMNMg NHrtcFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkG2OFc6PSd-Mk[xOlQ4QTV:L3G+
HepG2 NGHKflZCeG:ydH;zbZMhSXO|YYm= M2W1O|Ix|ryP M4\jclFp M1HtSYF1fGWwdXH0[YQhfGinIHHwc5B1d3SrYzDpcoR2[3Srb36gc4YhUUmLLUGwxsA> NGHrN5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkG2OFc6PSd-Mk[xOlQ4QTV:L3G+
HGL5 MWTBdI9xfG:|aYOgRZN{[Xl? NHu0N4M2OM7:TR?= Mkf6NlRp MVrpcoRq[2G2ZYOgZUBxem:2ZXP0bZZmKGWoZnXjeEBi\2GrboP0JIV1d3Cxc3nk[S=> MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF4OUC3OUc,OjZzNkmwO|U9N2F-
GC1a NFTPUZhCeG:ydH;zbZMhSXO|YYm= MonsOVDPxE1? NUn3RYlkOjSq MWPpcoRq[2G2ZYOgZUBxem:2ZXP0bZZmKGWoZnXjeEBi\2GrboP0JIV1d3Cxc3nk[S=> NFvi[oI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkG2PVA4PSd-Mk[xOlkxPzV:L3G+
A549 MX7BdI9xfG:|aYOgRZN{[Xl? NH\5UGozOCEQvF2= MX2yOIg> NF[4clJz\WS3Y3XzJINmdGxiZHXheIgh[2G3c3XkJIJ6KEiIQ2CgeJJm[XSvZX70 NU\iO5V7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PVQyPDlpPkK1O|k1OTR7PD;hQi=>
HeLa MkXTRZBweHSxc3nzJGF{e2G7 NXnVW4NOOTEQvF2= M4\q[VQ5cA>? NXG4eWtL\GWlbHnu[ZMhfGinIILheIUhd2ZiYYDvdJRwe2m|IHTyZY1ifGmlYXzsfS=> NYrNTYptRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3O|I2PDVpPkK1O|czPTR3PD;hQi=>
SGC-7901 MnL2RZBweHSxc3nzJGF{e2G7 MXOyNOKh|ryP Mn7KNYg> NIWwZ|FqdmirYnn0d{B1cGViY3XscEBl\WG2aDDpcoR2[2WmIHL5JI95[WyrcHzheIlv NUm5XmRIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OlcxPzZpPkK1O|Y4ODd4PD;hQi=>
MCF-7 MYfBdI9xfG:|aYOgRZN{[Xl? NH3yNowyOM7:TR?= M4\yUFJp MVvpcohq[mm2czD0bIUh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IEPC NV7FS|BlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3NlIyOTRpPkK1O|IzOTF2PD;hQi=>
A549 MVPBdI9xfG:|aYOgRZN{[Xl? NV7DfXpEOTBizszN MYOyOIg> NH7TN|ZFVVOR M2nSUpBzd22xdHXzJGhDSy22cnXheIVlKEF3NEmgZ4VtdCC|dYL2bZZidCBoIHH0eIVvfWG2ZYOgeIhmKGOuZXH2[YQhWEGUUDDlfJBz\XO|aX;u NGe4WI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[4N|U3QCd-MkW2PFM2Pjh:L3G+
U87 M3XXdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDz[5l4PTEQvF2= M4nz[|Fp NFHPOJZz\WOxdnXyd{Bk\WyuIHfyc5d1cCCocn;tJHROYiC2cnXheI1mdnR? MmXZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OEG2OlgoRjJ3NkixOlY5RC:jPh?=
Neocortical Neuron M{L2Om5mfXKxdH;4bYNqfHliQYPzZZk> MWSxNFDPxE1? MUKxbC=> MVPhcpRi\2:waYrld{BJd2mjbXnk[UBCNUmwZIXj[YQhVmW3cn;0c5hq[2m2eR?= MofxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4N{WwNFEoRjJ3Nke1NFAyRC:jPh?=
Primary human placental cytotrophoblasts M1fBfWFxd3C2b4Ppd{BCe3OjeR?= NWThfY9pOzEQvF2= NF3vN3EzPGh? NXjtdpJSTE2VTx?= MofNdoV3\XK|ZYOgeIhmKGmwaHnibZRqd25ib3[gNVHPui2KU1SyJIJ6KHS{aXPsc5NidsLi NFOzdZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[0NlU6Oid-MkW2OFI2QTJ:L3G+
MM MmHvRZBweHSxc3nzJGF{e2G7 NGXRZ3U2OM7:TR?= NUPEO4V5OjCvaX6= M{j0cZBienSueTDpcohq[mm2czDTTGsucW6mdXPl[EAh[2WubDDk[YF1cA>? MlO0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3M{CwPVgoRjJ3NUOwNFk5RC:jPh?=
DLD1 Moq4RZBweHSxc3nzJGF{e2G7 M2jPWFIxyqEQvF2= M1zN[VFp MmDXdIFzfGy7IILleoVze2W|IHPlcIwh[XCxcITvd4l{KGOjdYPl[EBjgSCZU2Cx NULzc5czRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1NlQzPDZpPkK1OVI1OjR4PD;hQi=>
MDA-MB-231 NX30Z3lYS3m2b4TvfIlkcXS7IFHzd4F6 NEfRS2oyOM7:TR?= NVPINJhsOWh? MlLxZZVodWWwdIOgZ4VtdCCmZXH0bEBi\nSncjDDTHVCKHS{ZXH0cYVvfA>? NXTMTVdTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1NlE2ODFpPkK1OVIyPTBzPD;hQi=>
MKN28 MYDBdI9xfG:|aYOgRZN{[Xl? MlzNNVDPxE1? NIfPTHg{OG2rbh?= MXfEUXNQ NX;kNnJrcW6qaXLpeJMhXE6ILd8xJJBtfXNiQ1jYMYlv\HWlZXSgZZBweHSxc3nz MmHNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MUO5OlAoRjJ3NUGzPVYxRC:jPh?=
HL-60 NGTaSZNEgXSxdH;4bYNqfHliQYPzZZk> MV:xNFDPxE1? MmrjNYg> MVPEUXNQ MX9CpIlueHKxdnXzJJZq[WKrbHn0fUBw\iCWQ17Bd{11emWjdHXkJINmdGy| MmjDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MEK5N|IoRjJ3NUCyPVMzRC:jPh?=
AGS M{DaUGFxd3C2b4Ppd{BCe3OjeR?= MWmxNO69VQ>? MY[xbC=> MoPndJJmfmWwdIOgZ5Vz[3WvaX6tbY5lfWOnZDDjcIVifmGpZTDv[kBk[XOyYYPlMVMtKC16LDDhcoQhNTlicILveIVqdnN? MlzLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OUKyNVQoRjJ3NEmyNlE1RC:jPh?=
A549  NWfsS4E3SXCxcITvd4l{KEG|c3H5 MYGxNO69VQ>? NHi5UWkzPGh? NGPw[pVjdG:la4OgSG1CWy2rbnT1Z4VlKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzDhcoQhWEGUUDDhcoQh[XCxcITveIlkKGOnbHyg[IVifGh? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR|NEm4PUc,OjV2M{S5PFk9N2F-
INS-1 MXvBdI9xfG:|aYOgRZN{[Xl? M37uS|Ux|ryP MWS2bC=> NF\kXWtFVVOR M1PaVIRm[3KnYYPld{B1cGVicILvdI9zfGmxbjDv[kBm[XKueTDhdI9xfG:2aXOgZ4VtdHQEoB?= NFXkWm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUSzNFg6Pyd-MkW0N|A5QTd:L3G+
Primary hepatocytes  MoPWRZBweHSxc3nzJGF{e2G7 M3;sVlUx|ryP NI\IV2oyQGh? NGD5RZJqdmirYnn0d{BieG:ydH;zbZMhd2ZiaHXwZZRw[3m2ZYOgbY5lfWOnZDDifUBC[3RiRDDhcoQhXE6ILd8x NYLIflNORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0NFc2OzhpPkK1OFA4PTN6PD;hQi=>
L929-A  MXnDfZRwfG:6aXPpeJkhSXO|YYm= NU[0dppzOjEEoN88US=> NY\NcoxCOjSq M4nVO4lvcGmkaYTzJHRPTs7zLXnu[JVk\WRiY3XscEBl\WG2aB?= M4OwZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{m4OVQxLz5{NUO5PFU1ODxxYU6=
L929-N NXT1UIk1S3m2b4TvfIlkcXS7IFHzd4F6 MmnuNlDDqM7:TR?= NVeycmF5OjSq MV;lcohidmOnczDk[YF1cCC4aXGgZZV1d2O{aX7lJHRPTs7zIIDyc4R2[3Srb36= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTN7OEW0NEc,OjV|OUi1OFA9N2F-
Cytotoxicity Assay M3XLTGNmdGxiVnnhZoltcXS7IFHzd4F6 NITKemQzOM7:TR?= NVHjbItsPDiq M{fVXJBz\X[nboSgUWhOTC2rbnT1Z4VlKGOnbHyg[IVifGh? NFXMc5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUO5NlEyPid-MkWzPVIyOTZ:L3G+
COS7 MnnQT4lv[XOnIFHzd4F6 MoXWNVDPxE1? NXLFXI52OjSq MWLpcoNz\WG|ZYOgZ4F{eGG|ZTCzM|ch[WO2aY\peIlmew>? NYnFe|RDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzPFQxOjVpPkK1N|g1ODJ3PD;hQi=>
COS7 NU\PSFJbSXCxcITvd4l{KEG|c3H5 MXGxNO69VQ>? MVe0PIg> NYjRcmpreGG{dHnhcIx6KHC{ZY\lcpRm\CCIQ{GwNU1qdmS3Y3XkJINmdGxiZHXheIg> MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTN6NECyOUc,OjV|OESwNlU9N2F-
A375 M3\NU2Fxd3C2b4Ppd{BCe3OjeR?= NHnv[mE{OM7:TR?= MkPnNog> MV3wdoV3\W62czD0bIUh\HK3Zz3pcoR2[2WmIGDBVnAh[2ynYY\h[4U> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTN5NkGxOUc,OjV|N{[xNVU9N2F-
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