Z-VAD-FMK

目录号:S7023

Z-VAD-FMK Chemical Structure

Molecular Weight(MW): 467.49

Z-VAD-FMK是一种细胞渗透性的,不可逆泛caspase抑制剂,在THP.1 和 Jurkat T细胞中阻断细胞凋亡的所有特性。

规格 价格 库存 购买数量  
RMB 962.65 现货
RMB 3841.92 现货
有超大折扣

今日订购,明日送达,全国免运费!

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用该产品的5个实验数据:

  • (A) LAN5 cells were untreated (top panels) or treated with 50 µM of the caspase inhibitor Z-VAD-FMK (bottom panels). Cells were co-treated with nothing (No Rx), 1 µM GSK-J4, or 1 µM venetoclax for 48 hours and assayed for apoptosis by flow cytometry.

    Science, 2018, 10(441), doi: 10.1126/scitranslmed.aao4680. Z-VAD-FMK purchased from Selleck.

    After treatment with 1.5 g/l matrine in the presence or absence of 10 nM Baf A1 or 20 nM rapamycin or 10 lM z-VAD-FMK (zVAD) for 24 hrs, the cell viability was measured by CCK-8 assay. Results were expressed as mean±S.E.M. representing at least three independent experiments. *P < 0.05, versus matrine alone group.

    J Cell Mol Med, 2017, 21(6):1171-1181. Z-VAD-FMK purchased from Selleck.

  • (A and B) Western blot analysis examining the effect of zVAD-fmk on the icaritin-induced apoptosis. The caspase inhibitor zVAD-fmk could significantly decrease the icaritin-induced cleaved caspase-3 expression. β-Actin protein levels indicate that an equal amount of protein was loaded into each lane.n=3. Mean±SD. bP<0.05, compared to the control group. eP<0.05, compared to the icaritin-treated group.

    Acta Pharmacol Sin 2014 35(4):531-9. Z-VAD-FMK purchased from Selleck.

    Active caspase-3 expression analysis. SW1116 cells were treated with ZBH-1205, CPT-11 and SN38 at 25 μmol/L for 48 h, in the presence or absence of Z-VAD-FMK (50 μmol/L, 1 h ahead of time). *P= 0.0345. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). E: Cell cycle analysis. F: Apoptosis analysis. #P=0.0259. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). ALL experiments were repeated three times.

    Arch Biochem Biophys, 2016, 604:74-85.. Z-VAD-FMK purchased from Selleck.

  • Effect on the RAS of CFZ, z-VAD-fmk, or CFZ + z-VAD-fmk treatments administered 5 or 12 days after C26 inoculation and control groups. Western blot analysis of ATF2 and pATF2. CP, ZP and UP were treated for 5 days; CT, ZT, UT and CC were treated for 12 days. CFZ (CP), z-VAD-fmk (ZP), CFZ + z-VAD-fmk (UP), PBS only (CC), healthy control (HC).

    Med Oncol, 2015, 32(4): 538 . Z-VAD-FMK purchased from Selleck.

产品安全说明书

Caspase抑制剂选择性比较

生物活性

产品描述 Z-VAD-FMK是一种细胞渗透性的,不可逆泛caspase抑制剂,在THP.1 和 Jurkat T细胞中阻断细胞凋亡的所有特性。
特性 Z-VAD-FMK是研究细胞凋亡的一种关键化合物。
靶点
Pan-caspase [1]
(THP.1, Jurkat T-cells)
体外研究

Z-VAD-FMK(10 mM)作用于THP.1细胞,抑制细胞凋亡。Z-VAD-FMK(10 μM)作用于THP.1细胞裂解液,抑制PARP蛋白酶活性的激活。Z-VAD-FMK(10 mM)作用于完整THP.1和 Jurkat细胞,抑制CPP32加工。[1]Z-VAD-FMK(50 μM)与Camptothecin共处理HL60细胞,废除Camptothecin处理的细胞凋亡形态。Z-VAD-FMK(50 μM)作用于HL60细胞,抑制Camptothecin诱导的DNA分裂。[2]Z-VAD-FMK (50 μM)作用于S2细胞,提高转染细胞的生存百分数从26%提高到63%。[3]Z-VAD-FMK(>100 μM)作用于人类嗜中性粒细胞,增强TNFα-诱导的中性粒细胞凋亡,较低浓度(1-30 μM)时完全抑制TNFα刺激的细胞凋亡。[4]Z-VAD-FMK (10 mM) 作用于早期角膜基质细胞,抑制细胞凋亡。[5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GC1a NF\WbWlCeG:ydH;zbZMhSXO|YYm= NUDyTZM4PTEQvF2= NYr1VIV5OjSq MlKxbY5lcWOjdHXzJIEheHKxdHXjeIl3\SCnZn\lZ5Qh[WejaX7zeEBmfG:yb4Pp[IU> MV[yOlE3QTB5NR?=
HGL5 MlTDRZBweHSxc3nzJGF{e2G7 M4\KRVUx|ryP NHjscXQzPGh? MoX6bY5lcWOjdHXzJIEheHKxdHXjeIl3\SCnZn\lZ5Qh[WejaX7zeEBmfG:yb4Pp[IU> MU[yOlE3QTB5NR?=
HepG2 NVHub|JGSXCxcITvd4l{KEG|c3H5 MV6yNO69VQ>? NUTrb2NVOWh? Mnf2ZZR1\W63YYTl[EB1cGViYYDvdJRwfGmlIHnu[JVkfGmxbjDv[kBKUUlvMUFCpC=> MnO4NlYyPjR5OUW=
BEL-7402 M{PT[2Fxd3C2b4Ppd{BCe3OjeR?= MmnyNlDPxE1? Mlq2NYg> NXroZlU3[XS2ZX71ZZRm\CC2aHWgZZBweHSxdHnjJIlv\HWldHnvckBw\iCLSVmtNVDDqA>? MYSyOlE3PDd7NR?=
CEF Ml3GT4lv[XOnIFHzd4F6 Moq2NEw{Oyx4NzyxNFDPxE1? NVrWTZN4OTWvaX6= MY\kc5dvNXKnZ4XsZZRmeyCSUjDlcpp6dWViYXP0bZZqfHlidH:gOFDwxIViYYSgNVAx|ryP MVuyOlExOjN|OR?=
SP2/0 NWrZW2l6SXCxcITvd4l{KEG|c3H5 M1PYXFExOM7:TR?= MUSxbC=> NVXEUJdWTE2VTx?= NWrKUWxV[myxY3vzJJRp\SCjcH;weI9{cXNib3[gV3AzNzBiY3XscJM> MoLGNlYxPzR5M{K=
HUVEC-2c MUPBdI9xfG:|aYOgRZN{[Xl? M2G0TVUx|ryP MWi2bC=> NHrvN|Jl\WO{ZXHz[YQhfGinIH;4MWxFVC2rbnT1Z4VlKGG3dH;wbIFogQ>? Mk[2NlYxOjF5Mkm=
U1 NITFTnpCeG:ydH;zbZMhSXO|YYm= MXiwMVExOM7:TR?= MWiybC=> NGfEfWZz\WS3Y3XzJIRzfWdvaX7keYNm\CCjcH;weI9{cXNiYX7kJJN2[nOncYXlcpQhUEmYLUGgdoVxdGmlYYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NX;tSHJ5OjV7OEC5OFI>
ACH-2 NVfKdXdzSXCxcITvd4l{KEG|c3H5 MY[wMVIxOM7:TR?= Ml7JNog> M4DsT5Jm\HWlZYOg[JJ2\y2rbnT1Z4VlKGGyb4D0c5NqeyCjbnSgd5Vje2WzdXXueEBJUVZvMTDy[ZBtcWOjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> M1ztclI2QThyOUSy
U1 NEPiXnhMcW6jc3WgRZN{[Xl? NYSxXnhwOTByzszN NUjIenFrOmh? NGGwXmdqdmirYnn0d{Bk[XOyYYPlMVM> NFzMWmwzPTl6MEm0Ni=>
A549/V16 MYfBdI9xfG:|aYOgRZN{[Xl? MkPYOVDPxE1? M1j4RlFp NGLVWphz\XC{ZYPz[ZMhXEdxVF2tbY5lfWOnZDDhdI9xfG:|aYO= MnKxNlU6PDZyM{O=
SGN MVvBdI9xfG:|aYOgRZN{[Xl? MoHVNlBuVQ>? NVjSeIhiPDiq M17pUYhieyCwbzDpcoZtfWWwY3Wgc44hSUmILDDjZYxx[WmwIHX4dJJme3Orb36gc5Ih[2WubDDhdI9xfG:|aYO= M1;XeVI2QDd2NkOz
HCT116  NEDFVoJCeG:ydH;zbZMhSXO|YYm= MUO1NO69VQ>? MlXUNog> MYfpcohq[mm2czD0bIUh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IFTEWnA> M1zBdFI2QDZ6OEG4
DTK-SME MYDBdI9xfG:|aYOgRZN{[Xl? M3TadFUx|ryP MVyybC=> MoXpSG1UVw>? NFvs[2xx[XK2aXHscJkhcW6qaXLpeJMhfGinIHHwc5B1d3OrczDpcoR2[2WmIHL5JIJ2eGm4YXPhbY5m NHf3SlAzPTh2M{i5Oy=>
HL-60 NEfvVoJCeG:ydH;zbZMhSXO|YYm= NH7ZWG02OM7:TR?= NEC0ZVE1QGh? MXfy[YR2[2W|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JHNMUS2LSTD0doVifG2nboVCpC=> MX2yOVgzPDB2Mx?=
U937 Mn;uRZBweHSxc3nzJGF{e2G7 NECzbJc2OM7:TR?= NIjzd2c1QGh? M2nybpJm\HWlZYOgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhW0uLLVnJJJRz\WG2bXXueOKh NUfubmJQOjV6MkSwOFM>
A549 NFTxWGtCeG:ydH;zbZMhSXO|YYm= NYPmNmtSOjBizszN NFHLNmYzPGh? M4DR[ZJm\HWlZYOgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhUE[FUDD0doVifG2nboS= M4j4b|I2Pzl2MUS5
HeLa Mk\uRZBweHSxc3nzJGF{e2G7 MoPnNVDPxE1? MnLqOFhp MWDk[YNtcW6nczD0bIUhemG2ZTDv[kBieG:ydH;zbZMh\HKjbXH0bYNidGy7 M3fFNFI2Pzd{NUS1
SGC-7901 NUfESWdUSXCxcITvd4l{KEG|c3H5 MlrtNlDDqM7:TR?= MWexbC=> MmjKbY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiaX7keYNm\CCkeTDvfIFtcXCuYYTpci=> NHnmeGEzPTd4N{C3Oi=>
MCF-7 NUfOO2FQSXCxcITvd4l{KEG|c3H5 NFvzToMyOM7:TR?= MYOybC=> MVjpcohq[mm2czD0bIUh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IEPC M4fXPVI2PzJ{MUG0
A549 MXfBdI9xfG:|aYOgRZN{[Xl? M3zISFExKM7:TR?= MX2yOIg> MUfEUXNQ NEK2cXpxem:vb4Tld{BJSkNvdILlZZRm\CCDNUS5JINmdGxic4Xyeol3[WxiJjDheJRmdnWjdHXzJJRp\SClbHXheoVlKFCDUmCg[ZhxemW|c3nvci=> NWnEUIdDOjV4OEO1Olg>
U87 NES5TYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjCXm91PTEQvF2= M2i3UlFp M{TDWJJm[2:4ZYLzJINmdGxiZ4Lve5RpKG[{b32gWG1bKHS{ZXH0cYVvfA>? MVKyOVY5OTZ4OB?=
Neocortical Neuron M2roTG5mfXKxdH;4bYNqfHliQYPzZZk> NWHmSJNDOTByzszN NVvGfJRsOWh? M3HuPIFvfGGpb37pfoV{KEixaXHtbYRmKEFvSX7keYNm\CCQZYXyc5RwgGmlaYT5 NYrPN|d3OjV4N{WwNFE>
Primary human placental cytotrophoblasts M3yzfGFxd3C2b4Ppd{BCe3OjeR?= NYfFdFZGOzEQvF2= M1XCelI1cA>? MUPEUXNQ NEXIPIRz\X[ncoPld{B1cGViaX7obYJqfGmxbjDv[kAyOc7{LVjTSFIh[nlidILpZ4xwe2GwwrC= NHLpUYczPTZ2MkW5Ni=>
MM M2P1VmFxd3C2b4Ppd{BCe3OjeR?= MoT0OVDPxE1? MW[yNI1qdg>? NV3XWmppeGG{dHz5JIlvcGmkaYTzJHNJUy2rbnT1Z4VlKCClZXzsJIRm[XSq Mlr4NlU2OzByOUi=
DLD1 MUDBdI9xfG:|aYOgRZN{[Xl? M2PoflIxyqEQvF2= M1PN[VFp MonidIFzfGy7IILleoVze2W|IHPlcIwh[XCxcITvd4l{KGOjdYPl[EBjgSCZU2Cx NFzNcXozPTV{NEK0Oi=>
MDA-MB-231 NInBflFEgXSxdH;4bYNqfHliQYPzZZk> NVrQOI13OTEQvF2= NW\ZZZJSOWh? NXzUOm5{[XWpbXXueJMh[2WubDDk[YF1cCCjZoTldkBEUFWDIITy[YF1dWWwdB?= MXGyOVUzOTVyMR?=
MKN28 NF63V|BCeG:ydH;zbZMhSXO|YYm= MW[xNO69VQ>? NX2yZ|ZjOzCvaX6= MmPCSG1UVw>? M{SzcIlvcGmkaYTzJHRPTi4QsTDwcJV{KEOKWD3pcoR2[2WmIHHwc5B1d3Orcx?= M33JZVI2PTF|OU[w
HL-60 NEnlW|BEgXSxdH;4bYNqfHliQYPzZZk> MYKxNFDPxE1? NHrNZlMycA>? M2jwSmROW09? MlX5xsBqdXC{b4\ld{B3cWGkaXzpeJkhd2ZiVFPORZMufHKnYYTl[EBk\Wyucx?= MmPjNlU2ODJ7M{K=
AGS MYLBdI9xfG:|aYOgRZN{[Xl? NYfRTZJuOTEQvF2= MWCxbC=> NVfzUo8yeHKndnXueJMh[3W{Y4XtbY4ucW6mdXPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNuID24MEBidmRiLUmgdJJwfGWrboO= NVf4fWpNOjV2OUKyNVQ>
A549  MWrBdI9xfG:|aYOgRZN{[Xl? MYexNO69VQ>? NWDx[ZVmOjSq M{[xWIJtd2OtczDEUWFUNWmwZIXj[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHHu[EBieG:ydH;0bYMh[2WubDDk[YF1cA>? NETQS3QzPTR|NEm4PS=>
INS-1 MVjBdI9xfG:|aYOgRZN{[Xl? MlHNOVDPxE1? NYXmdYNEPmh? MYfEUXNQ M161dIRm[3KnYYPld{B1cGVicILvdI9zfGmxbjDv[kBm[XKueTDhdI9xfG:2aXOgZ4VtdHQEoB?= M2\lO|I2PDNyOEm3
Primary hepatocytes  MWTBdI9xfG:|aYOgRZN{[Xl? NWfLOFFsPTEQvF2= NVn1XJd2OTiq MXLpcohq[mm2czDhdI9xfG:|aYOgc4YhcGWyYYTvZ5l1\XNiaX7keYNm\CCkeTDBZ5QhTCCjbnSgWG5HNc7z M4TtR|I2PDB5NUO4
L929-A  MVTDfZRwfG:6aXPpeJkhSXO|YYm= NYDjVnBwOjEEoN88US=> M4exXVI1cA>? M4TDSolvcGmkaYTzJHRPTs7zLXnu[JVk\WRiY3XscEBl\WG2aB?= NHvScmkzPTN7OEW0NC=>
L929-N M1zQSGN6fG:2b4jpZ4l1gSCDc4PhfS=> NEjxUYIzOMLizszN NX34XGxTOjSq NHL1VXZmdmijbnPld{Bl\WG2aDD2bYEh[XW2b3PybY5mKFSQRt8xJJBzd2S3Y4Tpc44> M3O4T|I2Ozl6NUSw
Cytotoxicity Assay M1XxUmNmdGxiVnnhZoltcXS7IFHzd4F6 MUeyNO69VQ>? NXu5U3pvPDiq NXT4ZmV3eHKndnXueEBOUE2GLXnu[JVk\WRiY3XscEBl\WG2aB?= NIi5em4zPTN7MkGxOi=>
COS7 MWnLbY5ie2ViQYPzZZk> MkK1NVDPxE1? MWGyOIg> MUXpcoNz\WG|ZYOgZ4F{eGG|ZTCzM|ch[WO2aY\peIlmew>? NFXBS4czPTN6NECyOS=>
COS7 NGn6ZmFCeG:ydH;zbZMhSXO|YYm= M1v3bVEx|ryP MVG0PIg> NELhbYFx[XK2aXHscJkheHKndnXueIVlKE[FMUCxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> NI[zb2MzPTN6NECyOS=>
A375 MoPrRZBweHSxc3nzJGF{e2G7 MUGzNO69VQ>? Mo\GNog> NXqzW5NZeHKndnXueJMhfGinIHTyeYcucW6mdXPl[EBRSVKSIHPs[YF3[Wen NFr1O3UzPTN5NkGxOS=>
A549 MWfBdI9xfG:|aYOgRZN{[Xl? NYWxXoNNPTEQvF2= MV:yOIg> MX7y[ZZmenOnczDybYJwe2:vZTDibY9o\W6nc3nzJIFv\CCjcH;weI9{cXNiY3H1d4VlKGK7IDDDbIlrd26pZHHu M4KwXVI2OzR7N{ix
A549 NH7ITJhCeG:ydH;zbZMhSXO|YYm= NUX5PXZEOi53LUK1{txO MY[xbC=> NIrKXVRl\WO{ZXHz[ZMhfGinIIDvdJVt[XSrb36gc4Yh[XCxcITveIlkKGOnbHzzJIRmeGWwZDDvckBkd26lZX70doF1cW:wcx?= MoiyNlU{PDJ2Mke=
 NBL-W-S  NXjtPYRiSXCxcITvd4l{KEG|c3H5 M3fGR|Ux|ryP NIOzWGYycA>? MWfmeYxtgSC{ZYPjeYV{KGOnbHygeoli[mmuaYT5JIFnfGW{IFfBUnQuPjFidILlZZRu\W62 M3jlVlI2OzJ|MkKy
Caki-1  M4fqdmFxd3C2b4Ppd{BCe3OjeR?= NVPhT4d6PDEQvF2= MUm0PIg> NFPjXIhz\WS3Y3XzJJRp\SCwdX3i[ZIhd2ZiQX7u[ZhqdiCYLYDvd4l1cX[nIHPlcIx{ MXWyOVI4QTF7MR?=
769-P NH\TepFCeG:ydH;zbZMhSXO|YYm= MX[0NO69VQ>? NEHISHY1QGh? M3\iN5Jm\HWlZYOgeIhmKG63bXLldkBw\iCDbn7lfIlvKFZvcH;zbZRqfmViY3XscJM> MVOyOVI4QTF7MR?=
H9c2 MUfBdI9xfG:|aYOgRZN{[Xl? NY\IWYJ6PTEQvF2= NGj1d2oycA>? MlSxbY5pcWKrdIOgSG9ZNWmwZIXj[YQh[2G|cHHz[UA{KGGldHn2ZZRqd25iYoX0JI5wfCC2aHWgcI9{eyCxZjDj[Yxtew>? NXjpdXRyOjV{OEO4NVk>
K562 MV7BdI9xfG:|aYOgRZN{[Xl? MmPSOVDPxE1? M1XnUFRp M4rMXIlvcGmkaYTzJGpi[y2DLXnu[JVk\WRiY3XscEBieG:ydH;zbZM> M4jKSlI2OjRzNkG5
L929 NXn0eFdXSXCxcITvd4l{KEG|c3H5 MmTvNVDPxE1? MkLvOog> NHK3[3BqdmS3Y3XzJI5m[3KxcITvd4l{KHerdHigWG5H MWWyOVE6PTZ4MB?=
A549 M1PzW2Fxd3C2b4Ppd{BCe3OjeR?= NY\WS4lnOTEQvF2= NXPoZppmO2h? NHX1NI9z\WS3Y3XzJINmdGxiYYDvdJRwe2m|IHPheZNm\CCkeTDQVXE> MlGyNlUyPjF4OUm=
MCF-7 Mkj2RZBweHSxc3nzJGF{e2G7 NIXNeIEzOM7:TR?= MkPuNog> MUXk[YNz\WG|ZYOgT2RTNXOrUl7BMYlv\HWlZXSgZZBweHSxc3nz MUiyOVE5OjJ2MB?=
OS M2[0dmFxd3C2b4Ppd{BCe3OjeR?= NHX1dngzOC92MN88US=> M3npNVczcA>? NF3W[ZlqdmirYnn0d{BQWyClZXzsJJZq[WKrbHn0fUBz\WS3Y4Tpc44h[nliQ{[gZ4Vz[W2rZHW= M{XUfFI2OTV{M{m5
HUVECs NVy3PYtDSXCxcITvd4l{KEG|c3H5 NUnIUIhTOTEQvF2= MoPrNog> MV1CpIlvcGmkaYTzJIFxd3C2b4Ppd{BidmRiZnHjbYxqfGG2ZYOgZZV1d3CqYXf5JIlvKESHTm[yMYlv\mWldHXkJGhWXkWFcx?= NF:xNXIzPTF|OEewNy=>
EA.hy926 MnnjRZBweHSxc3nzJGF{e2G7 MWGxNO69VQ>? MUSybC=> NVnjfZhOyqCrbnjpZol1eyCjcH;weI9{cXNiYX7kJIZi[2muaYTheIV{KGG3dH;wbIFogSCrbjDESW5XOi2rbn\lZ5Rm\CCHQT7ofVkzPg>? MY[yOVE{QDdyMx?=
Ebs NYjkeGtxSXCxcITvd4l{KEG|c3H5 MUGxNE0yODEQvF2= MXuyOIg> MYhCpG1OXFNiZ3Xu[ZJifGmxbjDyZZRmKGSnY4LlZZNm\CCjczD0bIUh[2:wY3XueJJifGmxbjDv[kB7NV[DRD7mcYshcW6lcnXhd4Vl NILkWmgzPTF|NEixOy=>
Jurkat MlLlRZBweHSxc3nzJGF{e2G7 M{n4OlIx|ryP NHfIVFkzPGh? Mny2SG1UVw>? M3r0OJBienSrYXzsfUBqdmirYnn0JINmdGxiZHXheIghd2ZiSoXyb4F1KGOnbHzzJIlv\HWlZXSgZpkhOTByNUitSlQh[2:vYnnu[YQhf2m2aDDWVGHDqA>? NYfOZZBTOjVzMkC3NlM>
K562 MXnBdI9xfG:|aYOgRZN{[Xl? NHryOXIxNjFvMd88US=> MXWxbC=> M4K3e4lvcGmkaYTzJINt\WG4YXflJI9nKEiVUEmwJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NYDSZXB6OjVzMUmxPFg>
IMR-32 M2[3SGFxd3C2b4Ppd{BCe3OjeR?= NIDvOG01OMLizszNxsA> NGOzVWczcA>? Mle3[IVkemWjc3WgbY4h[XCxcITveIlkKGOnbHzzJINwdXCjcnXkJJRwKFRvMjD0c5hqdg>? Ml73NlUxQDR5NUW=
RPMI 8226 MmnRRZBweHSxc3nzJGF{e2G7 MYWxNFDPxE1? NX63S3A4OWh? MVfhcI1we3RiY3;tdIxmfGWueTDicI9kc3NiY3XscEBl\WG2aDDjZZV{\WRiYomgcoVkem:|dHH0bY4uOQ>? M1roOFI2ODN5OEWx
U266  MYTBdI9xfG:|aYOgRZN{[Xl? Mmj6NVAx|ryP M1nkV|Fp M3;YTpBienSrYXzsfUBjdG:la4OgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhdmWlcn;zeIF1cW5vMR?= M4fVNFI2ODN5OEWx
H929  NV6zWZBHSXCxcITvd4l{KEG|c3H5 NHqzPHkyODEQvF2= Mm\4NYg> MV\wZZJ1cWGubImgZoxw[2u|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JI5m[3Kxc4TheIlvNTF? MmXTNlUxOzd6NUG=
MM.1S  MlqyRZBweHSxc3nzJGF{e2G7 NYLDfo1wOTByzszN MoLONYg> M{K3V4Vn\mmlaXXueIx6KHC{ZY\lcpR{KHOxcnHm[Y5q[i2rbnT1Z4VlKGOnbHyg[IVifGhiY3;tZolv\SC5aYToJI5m[3Kxc4TheIlvNTF? M3fr[|I2ODN5OEWx
C6 NIr5d2RCeG:ydH;zbZMhSXO|YYm= NH\XNWg2OM7:TR?= M{XVWVQ5cA>? NWjFVpd7eHKndnXueJMhfGinIHzvd5Mhd2ZiY3XscEB3cWGkaXzpeJkh[2G3c3XkJIJ6KHC{ZXfu[Y5wdG:wZR?= NXzOW5Z3OjVyMUO0O|k>
AGS NV\GeHhnSXCxcITvd4l{KEG|c3H5 NHTmNZo2OM7:TR?= MVyyOIg> Mo\0ZYJwdGm|aIOg{tIudGGyYXPoc45mNWmwZIXj[YQh[2WubDDk[YF1cCCjbnSgbY5pcWKrdHXkJIdzd3e2aB?= NVq4dWp1OjVyMEm2PVg>
HeLa  MXrBdI9xfG:|aYOgRZN{[Xl? MkHsOFDPxE1? MUGyOIg> M3;meolvcGmkaYTzJJRp\SCrbnPy[YF{\WRiYYDvdJRwe2m|IHnu[JVk\WRiYomgd4lTVkZzMkG= NVzuWYVTOjR7Mki2PFU>
THP-1  MmjHRZBweHSxc3nzJGF{e2G7 MmPCNVDPxE1? MnPrNYg> MXPy[YR2[2W|IHHwc5B1d3OrczDpcoR2[2WmIHL5JGFNSS2VRGVCpC=> MV6yOFkzOzZ3Mx?=
P815  NWCzWFNFSXCxcITvd4l{KEG|c3H5 MofQNVAxKML3TR?= NXzid5VHOTKq M3HldmROW09? MVvpcohq[mm2czD2bZJ2ey2rbnT1Z4VlKGGyb4D0c5Nqew>? Ml64NlQ6OjN{N{O=
HCT116 NH3Ic2JCeG:ydH;zbZMhSXO|YYm= MnPGNlDPxE1? M3fY[VI1cA>? NUHy[G1M[WK{b3fheIV{KG:oIGTRMYlv\HWlZXSgZZBweHSxc3m= MVqyOFg6ODR2OR?=
SW1116  NXrhNWxsSXCxcITvd4l{KEG|c3H5 MYixNEDDvU1? NULIWHJ4OWh? NFvWbVBFVVOR NFLz[Ipz\XO2cnHpcpMh[2WubDDhdI9xfG:|aYOgbY5lfWOnZDDifUBo\W[rdHnubYIheGy3czDk[YNqfGGkaX7l MlzYNlQ5PzR{OE[=
LOVO MUfBdI9xfG:|aYOgRZN{[Xl? NVvPToV3OTBiwsXN NH\VTpgycA>? MoHoSG1UVw>? NHXUVFVz\XO2cnHpcpMh[2WubDDhdI9xfG:|aYOgbY5lfWOnZDDifUBo\W[rdHnubYIheGy3czDk[YNqfGGkaX7l MmfYNlQ5PzR{OE[=
SNU449  MknaRZBweHSxc3nzJGF{e2G7 MUSyNO69VQ>? NXvQPYtzPDiq MmLxSG1UVw>? MmHS[IVkemWjc3XzJI1qWi12NUGtbY5lfWOnZDDhdI9xfG:2aXO= M3vSO|I1QDRzNkO4
Caco-2 MnHRRZBweHSxc3nzJGF{e2G7 NGfKWZc1OOLCid88US=> MX20bC=> MmfBdJJmfmWwdIOgV3QuPy2rbnT1Z4VlKFqRLUGgZ4hidmenczDhcoQhXEWUIHTyc5A> M{\1blI1QDJ{MUiz
macrophage MojWR4VtdCCYaXHibYxqfHliQYPzZZk> M3XOeFAuOjByzszN MWmyOIg> NFzQNlNqdmS3Y3XzJHRPTi1iYX7kJHJqeDNvZHXw[Y5l\W62IH7lZ5JweHSxc3nzJIlvKG2jY4LvdIhi\2V? NXvkO|dGOjR5OUm1OlU>
AGS  MmLPRZBweHSxc3nzJGF{e2G7 NHPm[VUzOM7:TR?= MlTLNVJp MoPZSG1UVw>? M4H4N5Jm\HWlZYOgeIhmKGmwZIXjeIlwdiCxZjDhdI9xfG:|aYOgbY4hemW|cH;ud4UhfG9idHjlJGV1V0GlIH\yZYN1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ NV7GUpJ2OjR5OEm3NFM>
LCC9  MVzD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NHPjPVMyODEQvF2= NHPjboM2\A>? M17td4Jtd2OtczDj[YxtKGSnYYToJIlv\HWlZXSgZpkh[2:vYnnuZZRqd25iTEG3JIFv\CClaHzvdo9yfWmwZR?= NWXHU3BDOjR5OEWyOVY>
U937  NGThXWlv\WO{b4D0c5NqeyCDc4PhfS=> MkS3NVDDqM7:TR?= Mn7KN|DDqG2rbh?= M{TGbolv\HWlZYOgcoVkem:ydH;zbZMh[2:vYnnu[UB4cXSqIGTOSi=> NFXIdJUzPDd5M{e1Oi=>
T cell MmDPR4VtdCCycn;sbYZmemG2aX;uJIF{e2G7 NXm2W442OC1zMEFOwG0> M1rLZVczcA>? NGn3OFlKSzVyPUewJO69VSxiaX7obYJqfHNiYX70bU1ETDNvaX7keYNm\CCWIHPlcIwheHKxbHnm[ZJifGmxbjDpckBRSk2Fcx?= MmrkNlQ4Pjh5MEe=
HeLa  NVv3UWRKSXCxcITvd4l{KEG|c3H5 NF7ofXM2OM7:TR?= NHjEWm84Omh? MXTEUXNQ MU\wdoV3\W62czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkd22yb4Xu[JPDqDIkgKO1 MWSyOFc2PDd6Nh?=
HeLa  NH75cY9CeG:ydH;zbZMhSXO|YYm= M33lS|ExOM7:TR?= NXjwZmJSOjSq MoHmd5VxeHKnc4Pld{Bz[XSnIH;mJINmdGxiZHXheIghcW6mdXPl[EBjgSCxdnXy[ZhxemW|c3nvckBw\iCJNUnTJI9zKEd5MWKgdFE2OGeudXXkxsA> M2mz[VI1PzJ{NE[4
IEC-6  NI\r[GZCeG:ydH;zbZMhSXO|YYm= M1\VNlEx|ryP NWX5WJZqOjSq M{jTNZBz\X[nboTzJHRk\EFvaX7keYNm\CClYYPwZZNmNTNiY3zlZZZi\2ViYX7kJO6zNWOjdHXubY4h\GWpcnHkZZRqd25? NWDpXnc2OjR5MUG1O|E>
HCT116 MYXBdI9xfG:|aYOgRZN{[Xl? MoTDNlDPxE1? NXPJe5p1OjSq M1jOWYlvcGmkaYTzJJRp\SClZXzsJIFxd3C2b4TpZ{BqdmS3Y3XkJIJ6KFmOVEKwOS=> MXmyOFcyOzhzMh?=
L02 Mk[yRZBweHSxc3nzJGF{e2G7 NWjzXIVzOjEQvF2= NVrmeFZQOWh? MYjwdoV3\W62czD0bIUh[2WubDDhdI9xfG:|aYOgbY5lfWOnZDDifUBOTUiS M{LafFI1PzB4NE[x
A375 NUPzZ|lRSXCxcITvd4l{KEG|c3H5 NWPB[lNiOjEQvF2= MXGyOIg> M3LnXZJmfmW{c3XzJIRq[2m2cnnuc45mKEJvaX7keYNm\CCjcH;weI9{cXN? NHzCW4kzPDZ7OUGxNS=>
HDPC M4i4cGFxd3C2b4Ppd{BCe3OjeR?= NHS1fJI2OML3TR?= NGq5WVIzPGh? Mm\ibY5pcWKrdIOgUm8ucW6mdXPl[EBieG:ydH;zbZM> MYWyOFY{PDV7Mx?=
A549 MnPBRZBweHSxc3nzJGF{e2G7 NEHofmQ2OML3TR?= MkHaNog> NUjad3dmTE2VTx?= Ml3adJJmfmWwdIOgeIhmKGi7cH;kbZBtd2mmIFTORUBkd262ZX70JJBp[XOnIHnu[JVk\WRiYomgZ4VxcGGub3Podo9ucW5? NHTnNWozPDV6OEGzOS=>
 BV-2 NGLEbJZCeG:ydH;zbZMhSXO|YYm= NWi1Z4o2OjEQvF2= NXX0e5k5Omh? NEXIbmV{fXCycnXzd4V{KFWYLXnu[JVk\WRiY3jyc41ifGmwIHX4eJJ2e2mxbjDhcoQh\GmuYYTpc44hd2ZidHjlJI52[2ynYYKg[Y53\WyxcHW= NWDyO|BYOjR3NUixNVg>
HT-29  MkfHRZBweHSxc3nzJGF{e2G7 M2m1bVUx|ryP NFnFR5U1QGh? MkfaZoxw[2u|IITo[UBieG:ydH;zbZMhcW6mdXPl[EBjgSCtYXXtdIZmem:u MY[yOFU1QTF5NR?=
A549 NIPYNJFCeG:ydH;zbZMhSXO|YYm= NWTISXBIPc7:TR?= NX3H[mZSOjSq MYnzeZBxemW|c3XzJFZmyqBqQluxNFA1OClvaX7keYNm\CCjcH;weI9{cXQEoB?= NHvrPJQzPDV{OUi3NS=>
MIA-PaCa-2 MXvBdI9xfG:|aYOgRZN{[Xl? MVyyOIg> MmjYZoxw[2u|IHPs[YF3[WenIH;mJINie3Cjc3WtN{BqdmS3Y3XkJIJ6KGKxdHigRU01PDN4NUSgZY5lKHCjY3zpeIF5\Wx? NHLVR5EzPDVzMEm5Ni=>
Caki-1 MnX2RZBweHSxc3nzJGF{e2G7 NUC2dWNCOjEQvF2= MlWxNYg> NYTGWmZGcW6qaXLpeJMhW0OSLXnu[JVk\WRiYYDvdJRwe2m| MnnvNlQ2ODR4OEG=
CLL MnPDRZBweHSxc3nzJGF{e2G7 MWiyOe69VQ>? NEGyNW8ycA>? NWTSSZJleGG{dHnhcIx6KGKub3Prd{BOVE5{MkO4MYlv\HWlZXSgZ4VtdCCjcH;weI9{cXN? MYeyOFQ3PzZ|NB?=
SGC-7901 MULBdI9xfG:|aYOgRZN{[Xl? MkTJNVDPxE1? MmXsNlRp NIfFNZVxem:vb4Tld{B1cGViQ1fJTU1qdmirYnn0[YQh[2WubDDndo94fGhiaX6gV2dENTd7MEGgZ4VtdHN? M{i0NlI1PDV2NEi4
k1735 NVe3e5lxSXCxcITvd4l{KEG|c3H5 MWCyNQKBkc7:bR?= Mne1OIg> NF76UFhqdmirYnn0d:KhW2GubX;u[Yxt[S2rbnT1Z4VlKGGyb4D0c5Nqew>? NIH3bXYzPDR3MUGxOi=>
HaCaT  NV\lclJTSXCxcITvd4l{KEG|c3H5 MVqxNFDPxE1? MX:xbC=> MXzicJVvfHNiVW\CMYlv\HWlZXSgZZBweHSxc3nzJIlvKEijQ3HUJINmdGy| NW\lWotYOjR|NU[5PVc>
podocytes NV\xVHV4SXCxcITvd4l{KEG|c3H5 NETvSJkzODEQvF2= NX64XG8xPmh? M3nRPYlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KDNuND3ES2U> M1H6clI1OzN5N{e3
 KB NYDtW|d{SXCxcITvd4l{KEG|c3H5 Mmf4OVDPxE1? M3LMflI1cA>? M1XTbIlvcGmkaYTzJGxq[29vQT3pcoR2[2WmIHPhd5Bie2VvMzDhcoQhWEGUUDDhZ5RqfmG2aX;u NV;MSFlbOjR|M{e0PVI>
 HepG2  NH3a[GtCeG:ydH;zbZMhSXO|YYm= MmLlNVDPxE1? NFTEOIEzPGh? MXXy[YR2[2W|II\pcYVvfGmwIHPs[YF3[WenIHPheZNm\CCkeTDMVHM> MnfMNlQ{OjV6MU[=
fetal rat lung fibroblasts  MXLLbY5ie2ViQYPzZZk> Mnq5PFDPxE4EoB?= NESwfHkycA>? MUPpcohq[mm2czDDZZNx[XOnLUOgZYN1cX[rdIpCpC=> M3fje|I1OzF2MUO1
PDL fibroblasts MnnwT4lv[XOnIFHzd4F6 MkTIPFDPxE4EoB?= M2j0VlFp NVH1bYxFcW6qaXLpeJMhS2G|cHHz[U0{KGGldHn2bZR6yqB? M1rK[FI1OzF2MUO1
MB49 M2DkPGFxd3C2b4Ppd{BCe3OjeR?= M{TaT|Ix|ryP MVWxbC=> M2rGV5JmfmW{c3XzJGNONWmwZIXj[YQh[2WubDDk[YF1cA>? NUfRVXdIOjR{OEK0N|M>
5637 NILHSplCeG:ydH;zbZMhSXO|YYm= MoCxNlDPxE1? MnPINYg> NHLMN4hz\X[ncoPld{BEVS2rbnT1Z4VlKGOnbHyg[IVifGh? NY\6OWtYOjR{OEK0N|M>
A549  NGfUeXZCeG:ydH;zbZMhSXO|YYm= NWTm[pdCOTByzszN Ml;EOFhp NVTDflhye3WycILld5NmeyC2aHWgZZBweHSxc3nzJINifXOnZDDifUBxcXCncnnu[eKh MmrLNlQzPzJ{MEG=
MCC-2 NEDxdWdCeG:ydH;zbZMhSXO|YYm= M{LFR|IxKM7:TR?= NG\kemc3cA>? NUD5TYgxTE2VTx?= Moe3Zoxw[2u|IHnu[JVk\WRiYomgd5RifXKxc4Dvdolv\SCjcH;weI9{cXNiY3XscEBl\WG2aB?= NULRblA2OjR{NkK2OVg>
ADF NFjWNVNCeG:ydH;zbZMhSXO|YYm= NFPIRWk1OM7:TR?= NXLsT2NlPmh? M3;zTolvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGOqZX3veIhmemGyeTDwcJV{KFqwQ3yy MlnCNlQzOjh{M{K=
 U373  Mk\nRZBweHSxc3nzJGF{e2G7 NX2zRllLPDEQvF2= NXnnOoRNPmh? MlzibY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2inbX;0bIVz[XC7IIDseZMhYm6FbEK= MVGyOFIzQDJ|Mh?=
RKO-HIPK2i MXnBdI9xfG:|aYOgRZN{[Xl? Ml\NOFDPxE1? MWq2bC=> NYP2RnlRcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3jlcY91cGW{YYD5JJBtfXNiWn7DcFI> MVSyOFIzQDJ|Mh?=
HEC-1B NUGybHpjSXCxcITvd4l{KEG|c3H5 MofhNlDPxE1? MX[xbC=> M4P1XJJm\HWlZYOgWHAucW6mdXPl[EBieG:ydH;zbZPDqGOjc4Dhd4UuOyCjbnSgZ4F{eGG|ZT25 M1\JTlI1OjF|M{W4
4T1 NHPSNllE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MoHQNk42NTFyzszN NH;xO|Y1cA>? NX3sZYN7TE2VTx?= MXfy[ZNkfWW|IITo[UBkgXSxdH;4bYNqfHlib3[gOHQyKGOnbHzzJIlv\HWlZXSgZpkhW1CGVDDpckBiKGOxbnPlcpRz[XSrb36g[IVx\W6mZX70JI1idm6nch?= MVOyOFIxPjF4MR?=
OS  MmDxRZBweHSxc3nzJGF{e2G7 MnvmNlDPxE1? M3js[lRp M13HVolvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHPheZNm\CCkeTDQSHQ> NV;uSoU1OjR{MES5N|c>
RPE M1TPSWFxd3C2b4Ppd{BCe3OjeR?= M2nrcFExOM7:TR?= M1H1WlQ5cA>? MVTwZZJ1cWGubImgbY5pcWKrdIOgeIhmKGOjbIDhbY4uOSCjbnSgMVIh[WO2aY\heIlwdiCjczD3[YxtKGG|IITo[UBk[XOyYYPlJIFkfGm4YYTpc44> MmXPNlQzODJyNUK=
UD29a Ml;NRZBweHSxc3nzJGF{e2G7 NGjuclA2OM7:TR?= MlTSNlRp NU\ZO|d6cW6qaXLpeJMhfGinIHPlcIwh\GWjdHigZ4F2e2WmIHL5JG5WXDN? M33GdVI1OTlyNUe0
SH-SY5Y  M4HWTGFxd3C2b4Ppd{BCe3OjeR?= NFe4ZVkyOM7:TR?= M{\IcFI1cA>? NHHQcIxifHSnboXheIV{KGOjc4Dhd4Uh[WO2aY\heIlwdiCjbnSgZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KEiQRT2ySGc> NE\YOnczPDF2NUS2Ny=>
HeLa  MXXBdI9xfG:|aYOgRZN{[Xl? NYHXUVc3OTBxMkFOwG0> NY\SfnVSOjSq MYjpcohq[mm2czD0bIUh[WO2aY\peJkhd2ZidHjlJI1icm:{aYT5JI9nKHSqZTDt[Y1j\XK|IH;mJJRp\SClYYPwZZNmNW[jbXnsfS=> MVyyOFE{PzJ4Nh?=
SCCVII  NXfYOWhbSXCxcITvd4l{KEG|c3H5 NXG1[m91OjYQvF2= MV2xbC=> NXO3bJVrcW6qaXLpeJMhfGinIHPlcIwhc2mubHnu[{Bi\nSncjDkZZNifGmwaXK= NIDwU20zPDF{NkS2OC=>
RAW 264.7 MUfBdI9xfG:|aYOgRZN{[Xl? MVmyNO69VQ>? MojzNVhp M2WzeIlv[3KnYYPld{BNSzNvSVmv{tIu[WO2aX6gdoF1cW9iY3;tdIFz\WRidH:gSWNVXi2PT2OgeJJm[XSvZX70JI9vdHl? NWHCd4dTOjRzMU[3NFc>
A549  MULBdI9xfG:|aYOgRZN{[Xl? M{HlSFIvPc7:TR?= NIOxOGYzPGh? MVHk[YNz\WG|ZYOgc5Jq\G:waX6tbY5lfWOnZDDheZRweGijZ4mgZZMhf2WubDDhcoQhVG:|czDv[kDPnM,KbTDhcJNwKG:lY4XydoVlKGS3cnnu[{BifXSxcHjh[4lkKHC{b3Pld5M> MXmyOFExOjV{Mh?=
UM-SCC-10A  MVvBdI9xfG:|aYOgRZN{[Xl? MXu1NOK2VQ>? NHzhcHYzcA>? M4D1c5Jm\HWlZYOgZZBweHSxc3nzJIlv\HWlZXSgZpkhcGmpaD3kc5NmKGm|b3HsZY51d2yjY4TvcoU> NYHBcXhvOjRyOUi3OVM>
BGC-823 MmfuRZBweHSxc3nzJGF{e2G7 NYnwXYJKOTBizszN NIDUW24zPGh? NXPldIVFemWmdXPld{B1\XS{YX7kdolv\S2rbnT1Z4VlKGGyb4D0c5Nqe8Li M33qZ|I1ODl6NUGx
Nalm-6  MYLBdI9xfG:|aYOgRZN{[Xl? NWToO4JzOjEQvF2= M4mwRlRp NFfr[GVqdmirYnn0d{Bk[XOyYYPlMVgh[W6mIHPhd5Bie2VvMzDhZ5RqfmG2aX;uJIFv\CCSQWLQMVEh[2ynYY\h[4U> NUjiO3ZSOjRyM{m5Olc>
KHOS  NHr4U2xCeG:ydH;zbZMhSXO|YYm= MVi0NO69VQ>? NEm4NnczPGh? MUDicI9kc3NidHjlJIlv[3KnYYPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNiYX7kJHBCWlBiaX7keYNm\CCkeTDCRm1FO8Li MUiyOFAzPTN4MR?=
G292 NG\xb|RCeG:ydH;zbZMhSXO|YYm= M4TkfFQx|ryP M2DDZlI1cA>? M3HqPIJtd2OtczD0bIUhcW6lcnXhd4VlKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzDhcoQhWEGUUDDpcoR2[2WmIHL5JGJDVUR|wrC= MofXNlQxOjV|NkG=
MG-63 NFfKN2hCeG:ydH;zbZMhSXO|YYm= M1PrSlQx|ryP M4m3PFI1cA>? M1HKSoJtd2OtczD0bIUhcW6lcnXhd4VlKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzDhcoQhWEGUUDDpcoR2[2WmIHL5JGJDVUR|wrC= NFHQPYQzPDB{NUO2NS=>
EBV-transformed B cells MXnBdI9xfG:|aYOgRZN{[Xl? NELaZlMzOM7:TR?= M3rtdlJp NGHX[phFVVOR M1XqcIJtd2OtczDhcpRqNUOGOECgZY5lKGGwdHmtR2Q5PiCjboTpZo9lgS2rbnT1Z4VlKGGyb4D0c5Nqew>? M{CxcVI1ODB6NkK4
IM-9 B MULBdI9xfG:|aYOgRZN{[Xl? NWruUXd3OjEQvF2= NYT0bXM6Omh? NWPmWWQ6TE2VTx?= M1fVPYJtd2OtczDhcpRqNUOGOECgZY5lKGGwdHmtR2Q5PiCjboTpZo9lgS2rbnT1Z4VlKGGyb4D0c5Nqew>? MXWyOFAxQDZ{OB?=
CNE1 NF7UR5dCeG:ydH;zbZMhSXO|YYm= MmLwNlDPxE1? M4eyXFQ5cA>? M2DwN4Jtd2OtczDMT{1CNWmwZIXj[YQh[XCxcITvd4l{ NYT4d|ZTOjN7OEWwNlk>
CNE2 M2DBUGFxd3C2b4Ppd{BCe3OjeR?= M17xe|Ix|ryP M{DleFQ5cA>? M{HRboJtd2OtczDMT{1CNWmwZIXj[YQh[XCxcITvd4l{ MYOyN|k5PTB{OR?=
HL-60 MmjPRZBweHSxc3nzJGF{e2G7 MY[1NOK2VQ>? NIf1R24ycA>? NWT0R2pqTE2VTx?= NVPqOlczcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliQlGxOFU> MXyyN|k1QDd3MR?=
L929 NYG4T4pJSXCxcITvd4l{KEG|c3H5 M3XnNlEvOjYkgKO1xsDPxE4EoB?= M1fWWFI1cA>? NIXmW4NifWevZX70d{BVVkcQsT3pcoR2[2WmIH7lZ5JweHSxc3nzJIFv\CCjdYTvdIhi\3l? NGjzNYYzOzl2MUe2PS=>
Jurkat NGDP[5dE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MV6y{txO NHjOV2k1cA>? NUTiUZBoemW4ZYLz[ZMh\3Kxd4ToJIlvcGmkaYTpc44h[W6mIN8yMYNifGWwaX6g[IVkemWjc3WgZpkhUFNvQWPB NYeyNnJnOjN6OU[wOlE>
RAW264.7  NEC1SnBCeG:ydH;zbZMhSXO|YYm= NYPKfG5{OTBizszN NWHjZ21MOjSq M1;VOoRm[3KnYYPld{B1cGViYYDvdJRwe2m|IHnu[JVk\WRiYomgS2E> M2DEZ|I{QDJyMkCz
A431  NUf3b2NoU2mwYYPlJGF{e2G7 MXy0NO69VQ>? M{jWR|Jp NW\tZlJ7[myxY3vzJIZqe2W2aX6tbY5lfWOnZDDjcIVifmGpZTDv[kBk[XOyYYPld{BidmRiUFHSVC=> NU\U[XBHOjN6MECwOVg>
Jurkat M1fj[mNmdGxiVnnhZoltcXS7IFHzd4F6 NFfHUJgzPS1zMEFOwG0> Mmf4Oog> NYS1S5A2cW6qaXLpeJMhgi2IQT3DUWsucW6mdXPl[EBk\WyuIHTlZZRp NIr4RmQzOzl|M{WzNi=>
COS-7  M3v2RWZ2dmO2aX;uJGF{e2G7 NUSwbFV5PTEEtV2= NFzNRWczPGh? NHTRWG9i\m[nY4TzJJRp\SCycn;j[ZN{cW6pIH;mJGFVVjG|IIfpeIgheG:ueWGgeJJi[3S| MnjmNlM6OzN{MEi=
CAL27 MkXaRZBweHSxc3nzJGF{e2G7 Ml;JNVAh|ryP NIfFfZczcA>? Mmm1d5VxeHKnc4Pld{BEfXJvTmDzMZJm\HWlZXSgeoli[mmuaYT5JIJ6KHWyIITvJFkxLQ>? M4K0O|I{QTF5M{m2
THP-1  MWXBdI9xfG:|aYOgRZN{[Xl? M1;IdFExNTVyzszN MXyybC=> NUXGfVV4cW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nlidILpdJRwdGmmZR?= MnfuNlM6ODB{OUm=
K562 MWTBdI9xfG:|aYOgRZN{[Xl? NVTtcoJlOjEQvF2= MlnGOFhp MV;pcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUA1NU2X MXKyN|g4Pjh{Nh?=
HL-60 M2PYNGFxd3C2b4Ppd{BCe3OjeR?= MoHHNVAx|ryP MmraNlRp M3TMT4lvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGGkaXX0ZY5mKGSrdHXydIVv\XQEoB?= MmHsNlM5PjV5N{i=
HeLa  MVnBdI9xfG:|aYOgRZN{[Xl? NID1NJIzOM7:TR?= MUiybC=> MVXpcohq[mm2czDEUW1RKGmwZIXj[YQh[XCxcITvd4l{ NXzC[2JPOjN6NkO5OlY>
U251 M4L0UGFxd3C2b4Ppd{BCe3OjeR?= M4r0[FIx|ryP NY\CRY52OjSq NXHEc3dqcW6qaXLpeJMh[2G|dHnjbY4hcW6mdXPl[EBIOi:PIIDoZZNmKGG{cnXzeEBidmRiYYDvdJRwe2m| MY[yN|gyPjhzNh?=
HL-60 M2LyZ2Fxd3C2b4Ppd{BCe3OjeR?= NF;zUpg2OML3TR?= MVO0bC=> NUPZfYxD[myxY3vzJJRp\SClbHXheoFo\SCxZjDjZZNx[XOnLUOsJE06NCCjbnSgVGFTWCCrbnT1Z4VlKGK7IE\z M3;VVFI{QDB2N{C2
Ec-109 MoTLRZBweHSxc3nzJGF{e2G7 MV:xNEDPxE1? MUG0PIg> NHvweGdz\XC{ZYPz[ZMhWEVvbXXkbYF1\WRiRXOtNVA6KGOnbHygZZBweHSxc3nz MnTWNlM4QDJ4NEG=
RKO M3vReWNmdGxiVnnhZoltcXS7IFHzd4F6 NInjN3cyOCEQvF2= NHi3bnQzPGh? M2i2WIlvcGmkaYTzJJRp\SCmZXPy[YF{\SCxZjDj[YxtKH[rYXLpcIl1gSClYYXz[YQh[nliRFHC NGTsdmYzOzd3OEC2OC=>
T98G M375VWNmdGxiVnnhZoltcXS7IFHzd4F6 NYTZcol2OS1zMEFOwG0> MYKyOIg> M{m5UYlueHKxdnXzJINmdGxidnnhZoltcXS7IHPveJJm[XSvZX70JJdqfGhiVGO= NHPoZZQzOzd4OUK3OS=>
Jurkat NFLOb2dE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M336PFExOC1{MEFOwG0> NGfYZpAzPGh? M4LvTIlvcGmkaYTzJGhiSTRiaX7keYNmeyCjcH;weI9{cXNiZHXw[Y5l\W62IH;mJINwdmOnboTyZZRqd28EoB?= NGTVT4QzOzd|MkS4NS=>
Molt-3  NW\6WHhbSXCxcITvd4l{KEG|c3H5 MXu1NO69VQ>? MVKybC=> MnPOdoVlfWOnczDt[YxifG:waX6tbY5lfWOnZDDhdI9xfG:|aYO= NEjrbWczOzd{NUCxNy=>
hMSC12 NGTGVoxCeG:ydH;zbZMhSXO|YYm= NH3oOHoyODEQvF2= MVu0[C=> NID3PXZqdmirYnn0d{Bwe3Snb3flcolkKGO3bIT1doUucW6mdXPl[EBk\WyuIHTlZZRpKGGwZDDjZYxkcW[rY3H0bY9v MnT6NlM3PTd6MkK=
HM7  NYmyRXVISXCxcITvd4l{KEG|c3H5 NIrzXo0zOM7:TdMg MWmxbC=> NWfQUJp3[myxY3vzJIFxcWO3bHHy[Y4hSSCjY3X0ZZRmNWmwZIXj[YQh[2G|cHHz[U0{KGGldHn2ZZRqd25iYX7kJHBCWlBiY3zlZZZi\2V? NFi4NmczOzV6M{SxNi=>
Hep-2  M3e3RmFxd3C2b4Ppd{BCe3OjeR?= MoXmNlDPxE4EoB?= MYmyOIg> MUnEUXNQ MoHUZYxt\X[rYYTld{B1cGViZHXjdoVie2Vib3[gZ4VtdCC4aXHibYxqfHliaX7keYNm\CCkeTDzbYxq[mmwaX6= MlfxNlM2QDByM{K=
HSCs MYnBdI9xfG:|aYOgRZN{[Xl? NYKxUWpXPTEQvF2= MXyyOIg> NFnscI1FVVOR M{DWXIlvcGmkaYTzJI5qdG:2aX7pZk1qdmS3Y3XkJGRPSSCmYX3h[4UhcW6maXPheIVlKGK7IGDBVnAh[2ynYY\h[4U> MnqwNlM1QTl6N{S=
HL-60  NV;aS5N1S3m2b4TvfIlkcXS7IFHzd4F6 MUGyNO69VcLi M3\wRVI1cA>? MnLPdoVlfWOnczD0bIUh[3m2b4TvfIlkKGWoZnXjeEBw\iCHcom1 M{LOeVI{PDl2NEiw
HA MYLBdI9xfG:|aYOgRZN{[Xl? MUm1NO69VQ>? MWiyOIg> M{X1d5N2eHC{ZYPz[ZMhfGinIHPs[YF3[WenIH;mJHBCWlBiYX7kJINie3Cjc3WtN{whNTduIHHu[EAuQSCrbnT1Z4VlKGK7IHLvdpRmgm:vaXKvV2FJSQ>? NI\Y[Y8zOzR5NUm1Oi=>
C666-1 NEDzN4ZCeG:ydH;zbZMhSXO|YYm= MlzwOVDPxE1? NEHTT4QzPGh? NHS4XY1{fXCycnXzd4V{KHSqZTDjcIVifmGpZTDv[kBRSVKSIHHu[EBk[XOyYYPlMVMtKC15LDDhcoQhNTliaX7keYNm\CCkeTDic5J1\XqxbXniM3NCUEF? NHPBVGEzOzR5NUm1Oi=>
Hepa1-6 M3ntfGFxd3C2b4Ppd{BCe3OjeR?= NYSzZ|BLPTEQvF2= M2LMWFJp MWPpcohq[mm2czDjeZJkfW2rbjDhcoQhemW|dnXyZZRzd2xvaX7keYNm\CCjcH;weI9{cXN? M2DXOFI{PDR4N{Wz
PLC/PRF/5c NVrye4wzSXCxcITvd4l{KEG|c3H5 M3rje|Ux|ryP MnzlNYg> MoTQdJJmfmWwdIOgZZBweHSxc3nzJJRzcWepZYLl[EBjgSCFSV6= NF6w[JgzOzR|OEiyOC=>
HCT116 Mm\oRZBweHSxc3nzJGF{e2G7 MmSzNVAx|ryP M3W4TlEvPWh? NWDXVmVzcW6qaXLpeJMhV3NvaX7keYNm\CClZXzsJIRm[XSq MXOyN|c1PDN3Mx?=
HCEC MWLGeY5kfGmxbjDBd5NigQ>? MoW2OVDPxE1? NGjYfW04Omh? MYXEUXNQ MWXy[ZN1d3KnczDv[kB1cGVibn;ycYFtKEiFRVOgdIhmdm:2eYDl NG\6NoozOzd2MkCxNS=>
Primary rat cerebral cortical neurons MYDBdI9xfG:|aYOgRZN{[Xl? MnnINVAx|ryP M1fXZ|Fp MWDwdoV3\W62czDD[E1qdmS3Y3XkJIFxd3C2b4Ppd{BidmRiY3XscEBl\WG2aB?= NWLHbGNkOjN5NEGzNVc>
MDA-MB-231  M1XCPGFxd3C2b4Ppd{BCe3OjeR?= MXGyOe69VQ>? Mmf0NlRp NVr0ZmZS[WK{b3fheIV{KGO7dH;0c5hq[2m2eTDhcoQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHnu[JVk\WRiYomgVoc{ M3;IUlI2OzN5NUS0
NLRP3-Tet-on-MC/9  NIrnV|hCeG:ydH;zbZMhSXO|YYm= NGG3TI4yOC12MN88US=> MlnSNVJp Mnv2ZZR1\W63YYTld{B1cGViY3XscEBl\WG2aDDjZZV{\WRiYomgR2FRWy2jc4PvZ4lifGWmIF7MVnA{KG23dHHueJMhcW5idHjlJHRmfC2xbjDzfZN1\W1? M3TjXFI{PzB|M{i5
KNS42  M2jZNGFxd3C2b4Ppd{BCe3OjeR?= M4e3WFUx|ryP NHTVTncycA>? NHnwUJpz\WS3Y3XzJINmdGxiZHXheIgh[W6mIHPvcZBt\XSnbImgZYJwdGm|aHXkJINie3Cjc3WgN{84KGGldHn2bZR6KGmwIILld5BwdnOnIITvJGFDXC1{NkOvNmRIN22ndH\vdo1qdiClb33ibY5ifGmxbh?= MUOyN|Y6OTF2NR?=
MCF-7  NYfaOIdsSXCxcITvd4l{KEG|c3H5 MkHUNlDPxE4EoB?= MmrrO|Jp M1XDPYlvcGmkaYTzJIVyfW:uLTDhcoQhPC2RSGStcYVlcWG2ZXSgZZBweHSxc3nz NVuzTIw1OjN4N{W2OFM>
hCMEC/D3  NEjUOIxCeG:ydH;zbZMhSXO|YYm= MoHQNlXPxE1? MnLLO|Jp NXvpemcyemWmdXPld{BNfHiDIHnu[JVk\WRiYYDvdJRwe2m| MnzRNlM3PjVzOUi=
Jurkat M{PBOGFxd3C2b4Ppd{BCe3OjeR?= NWXsdZBJOTJwNT21NO69VQ>? MlnnNYg> MWLkc5NmKGSncHXu[IVvfGy7IIP1dJBz\XO|ZYOgV3BJNWmwZIXj[YQhWGG{LUSgZ4xm[X[jZ3WsJHBCWlBiY3zlZZZi\2VuIFTORUBnemGpbXXueIF1cW:wLDDhcoQhdG:|czDv[kB3cWGkaXzpeJk> MXqyN|Q1Ojl5Nh?=
CNE-1 M2DaTGFxd3C2b4Ppd{BCe3OjeR?= NUjUbJFXOjEQvF5CpC=> M1nMeVI1cA>? NH;DVWtqdmirYnn0d{BTSURyMEGtbY5lfWOnZDDj[YxtKGSnYYTo M3:3VlI{PDJ4OEWw
HONE-1 NVKyOlRKSXCxcITvd4l{KEG|c3H5 M1jSNFIx|ryPwrC= MUOyOIg> NUPrNWFocW6qaXLpeJMhWkGGMECxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> NIC2VIEzOzR{Nki1NC=>
astrocytes cell NXLGbFhISXCxcITvd4l{KEG|c3H5 Mn;tOFDPxE1? NVSwRXZDPmh? MVPy[YR2[2W|IHXhdox6KGGyb4D0c5NqeyCrbnT1Z4VlKGK7IIP0ZZVzd3Oyb4LpcoU> MY[yN|QyOTd5OB?=
U-937 M4DMO2Fxd3C2b4Ppd{BCe3OjeR?= MXSxNO69VQ>? MW[zNI1qdg>? MULwdoV3\W62czDUUmYucW6mdXPl[EBv\WO{b4D0c5Nqew>? MUOyN|QyODd2OB?=
MDA-MB-231 M1XWcGFxd3C2b4Ppd{BCe3OjeR?= MWSxNFDPxE1? M1:zZ|Fp NGXHVVVqdmirYnn0d{B{\W6|aYTpfoF1cW:wIITvJHRTSUmOIIXwc44hVVSGSDDkc5dvNXKnZ4XsZZRqd25? M1PqXlI{PDB6NEK5
HeLa  MUnBdI9xfG:|aYOgRZN{[Xl? M{SzTVExOM7:TR?= M2OzNlJp NWe3[FFE[myxY3vzJGpTWy1zNTDJcoR2[2W|IFHwc5B1d3SrYzDD[YxtKESnYYTo NUW0S|M1OjN|NESwOFU>
Ec109 MX\BdI9xfG:|aYOgRZN{[Xl? MWGxNO69VQ>? NFLleY03cA>? M3XVdoJtd2OtczDhdI9xfG:2aXOgZ49u[mmwYYTpc44hd2ZiVHH0MXNu[WOQNzDhcoQhemGmaXH0bY9v M{LXV|I{OzN6NU[4
H460  NGjtTIlCeG:ydH;zbZMhSXO|YYm= MUixNO69VQ>? M2TLZ|Zp NXq2PJpZ[myxY3vzJIFxd3C2b4TpZ{Bkd22kaX7heIlwdiCxZjDUZZQuW22jY163JIFv\CC{YXTpZZRqd25? M2H6[|I{OzN6NU[4
HeLa  NUL1fHU4SXCxcITvd4l{KEG|c3H5 M4TSOlUx|ryP NHLmNpoyNjWq MoSwZYJzd2ejdHXzxsBEcGyjbYnkbYEucW6mdXPl[EBieG:ydH;zbZM> Mn;JNlM{ODN6MES=
SK-HEP1 NX;MR3VYSXCxcITvd4l{KEG|c3H5 MXexNFDPxE1? NInDU|AycA>? NGPMeYZqdmirYnn0d{BEelRzIHHjeIl3[XSnZDDjZZNx[XOnLUOsJE04NCBvODygMVktKGGwZDDwc4x6MEGGUD3ybYJwe2VrIIDvcJlu\XKjc3W= MkLRNlM{ODJ4NUC=
QGY7701 M3T4TWFxd3C2b4Ppd{BCe3OjeR?= NWnoUIR3OjYQvF2= M1LHUVEvPWh? Mn\JbY5pcWKrdIOgZYNkfW23bHH0bY9vKG:oIIP1Zk1IOSCyaHHz[UBqdmS3Y3XkJIJ6KESRWDCrJJF2\XKlZYTpci=> NWPnbJNuOjN{NECwOlE>
HepG2 MnrnRZBweHSxc3nzJGF{e2G7 NWj6TIl2OjEQvF2= Mn7GN|BucW5? NXjTWYllcW6qaXLpeJMhfGinIHXubIFv[2WmIHPlcIwh\GWjdHigZpkh[2:vYnnu[YQhfHKnYYTt[Y51KG:oIHHwbYdmdmmwIHHu[EBVWkGLTB?= NVHiWG9WOjN{MkSyN|k>
U87  Mn;4RZBweHSxc3nzJGF{e2G7 M1fEO|I2|ryP NXmyOYo1Omh? MVjk[YNz\WG|ZYOgbZNwdGmzdXnybZRq\2WwaX6gLGlUVClvaX7keYNm\CCjcH;weI91cWNiY3XscEBl\WG2aDygZpV1KG6xdDDu[YNzd3SrYzDj[YxtKGSnYYTo NFXpTlczOzJ{OU[yOi=>
HSC-2 NUjjN|dRSXCxcITvd4l{KEG|c3H5 NEnUZXczPS93MN88US=> M1r2dVFp NUjET5RjcW6qaXLpeJMhW05vM{itbY5lfWOnZDDjfZRwfG:6aXPpeJk> NG\ROnUzOzF3NUK0PC=>
HSC-4 Ml;zRZBweHSxc3nzJGF{e2G7 Mk[xNlUwPTEQvF2= MYqxbC=> NWXieFY4cW6qaXLpeJMhW05vM{itbY5lfWOnZDDjfZRwfG:6aXPpeJk> MkXzNlMyPTV{NEi=
CL-1 NHnJWJJCeG:ydH;zbZMhSXO|YYm= NXLDZ25WOjEQvF2= M2[0dFFp NX;2Z5ZJ[myxY3vzJG9RPDR7IHnu[JVk\WRiY3XscEBl\WG2aB?= MUiyN|E{OTd6Mh?=
MEL MoHURZBweHSxc3nzJGF{e2G7 MWmyNO69VQ>? NVX4UGE6OjSq MXzEUXNQ NYDtWldGcW2yYXny[ZMhWDK[Nz3pcoR2[2WmIF3FUEBk\WyuIHHwc5B1d3Orcx?= NF\TUmczOzBzNEi4Oy=>
Bel-7402  NXvFXYZlS2G|cHHz[UBC[3SrdnH0bY9vKEG|c3H5 MXq1NO69VQ>? MYiybC=> Mn\UbY5pcWKrdIOgVGNGNWmwZIXj[YQh[W6xaXvpdy=> NHXERVQzOzByOEe0Ni=>
Eca-109 NEXGZ4xCeG:ydH;zbZMhSXO|YYm= NF7MR2QzPc7:TR?= M3;HTlMxdWmw MoO2bY5pcWKrdIOgRmouSjFzLXnu[JVk\WRiY3XscEBl\WG2aB?= MWiyN|A4Pjl4Nx?=
MEL NIPWO49CeG:ydH;zbZMhSXO|YYm= M4LXZlIx|ryP M1PmTVFp MlKzSG1UVw>? MW\pcZBicXKnczDQNng4NWmwZIXj[YQhVUWOIHPlcIwh[XCxcITvd4l{ NYLoSmRvOjNyMUS4PFc>
Bel-7402  NVrJbWFrSXCxcITvd4l{KEG|c3H5 NIC3O|E2OM7:TR?= NUnsfGNbOmh? NGnrfWVqdmirYnn0d{BRS0VvaX7keYNm\CCjbn;pb4l{ M2\vNVI{ODB6N{Sy
L929 MWjGeY5kfGmxbjDBd5NigQ>? NWqzPZB3Oi53zszN MWCxbC=> M3jIRYlv[3KnYYPld{BTUVBzIHX4dJJme3Orb36gZY5lKGW6YXPldoJifGWmIGTOSu6yNWmwZIXj[YQhdWm2b3Poc45lemmjbDDkfZNnfW6ldHnvckBidmRiUl;TJJBzd2S3Y4Tpc44> NEXPcGEzOzByMEWxPC=>
RCC  M3[xemNmdGxiVnnhZoltcXS7IFHzd4F6 MXyxNFDPxE1? NGC3VI0zPGh? NXrIc4s4emWlb4\ldoV{KHSqZTD2bYFjcWyrdImgc4Yh[2WubIOg[Zhxd3OnZDD0c{AyPWRvUFfKNi=> MnPWNlI6QTF2OUS=
NB2a/d1 MoXwRZBweHSxc3nzJGF{e2G7 MmfUNVAx|ryP MVm3Nog> NHSzTXlifHSnboXheIV{KHO2YYXyc5Nxd3KrbnWtbY5lfWOnZDDjZZNx[XOnIHHjeIl3cXS7LDDQRXJRNCCjbnSgeIF2KGOuZXH2ZYdm M{XUWlIzQTh6NUSx
T cell MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mme2NlUuOTByzszN MUKyOIg> NVviZVVb\G:|ZT3k[ZBmdmSnboTsfUBqdmirYnn0[YQhXCClZXzsJJBzd2yrZnXyZZRqd25ibXXkbYF1\WRidHjyc5VocCC2aHWgZ48ue3SrbYXsZZRqd25id3n0bEBidnSrLVPEN{BidmRiYX70bU1ETDJ6 MV[yNlk5OjV|OB?=
K562 NVu0d4tGSXCxcITvd4l{KEG|c3H5 NH\QcVEyODEQvF2= NWHISHYxOWh? MYTicI9kc3NiQXLuc4Jifmm|Y4XtxsBHNWmwZIXj[YQh[XCxcITvd4l{ M3rBVFIzQTd{M{ey
Jurkat  MUXBdI9xfG:|aYOgRZN{[Xl? NVKzPWU2PDEQvF2= MX2xbC=> NUTRUGE4[WKxbHnzbIV{KE[jc1ytbY5lfWOnZDDjZZNx[XOnIHHjeIl3[XSrb36gZY5lKGOnbHyg[IVifGh? NU\HcGxXOjJ7NEK3N|g>
BGC-823 M4r6S2Fxd3C2b4Ppd{BCe3OjeR?= MmHwNVAx|ryP Ml3ENYg> MXjwZZJ1cWGubImgdoV{[3WnczDj[YxteyCjZ3HpcpN1KGSjbXHn[UBw\iCmYXnkfoVqdg>? MUCyNlkzPjV2NR?=
Hep3B M1\PV2Fxd3C2b4Ppd{BCe3OjeR?= MUW1NO69VQ>? NHPzWVEycA>? MkLuZoxw[2u|IHHwc5B1d3OrczDpcoR2[2WmIHL5JGhGT0O| MVyyNlkzOzF3NB?=
LLC-PK1 MlLWRZBweHSxc3nzJGF{e2G7 NELGWHMzOM7:TR?= NUf5NFJbOWh? MmDhdJJmfmWwdIOgZ4l{eGyjdHnuMYlv\HWlZXSg[IVoemGmYYTpc44hd2ZiQYTnOUwh[mWlbHnuMVEtKGGwZDDBeIcyOiCycn;0[Ylvew>? MXSyNlg6PjB|Nx?=
A549 MkDERZBweHSxc3nzJGF{e2G7 M2PJPFUx|ryP MUGxbC=> M1\XSYJtd2OtczD0bIUhSkGLLXnu[JVk\WRiYYDvdJRwe2m|wrC= MkHENlI5QDd{MUW=
SGC-7901  M3i5TWFxd3C2b4Ppd{BCe3OjeR?= Mn:yNVDPxE1? NH6wdGozPGh? NF;UTnJqdmirYnn0d{DPui{Qsj3kbY1mfGi7bHHjdplte2ira3;ubY4ucW6mdXPl[EBieG:ydH;zbZPDqA>? MUWyNlg1QDV7Nx?=
DM6 MmP3RZBweHSxc3nzJGF{e2G7 MXKxNFDPxE1? MmnUO|Jp M3HlTYJtd2OtczDic5RpKEV{Rj2xJIFv\CCHMl\0dk1u\WSrYYTl[EBkgXSxdH;4bYNqfHl? MXyyNlgzPTN{OB?=
MCF-7, MDA-MB-468, Caco-2 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUe1NO69VQ>? M1vBO|Q5cA>? MYfpcohq[mm2czD0bIUh[2WubDDndo94fGhiaX7obYJqfGmxbjDpcoR2[2WmIHL5JJNieG:waX6= NH7ocIIzOjhyMEm2PC=>
A2750  NVTDWpNvSXCxcITvd4l{KEG|c3H5 MV2yNO69VQ>? NGezPGIzcA>? M4\3b2ROW09? NV:yS49j[myxY3vzJINie3Cjc3WgZ4xm[X[jZ3Wg[JVzcW6pIHjlcIVv[WyrbjD0doVifG2nboSgZY5lKHKnZIXj[ZMh[XW2b4DoZYdq[yClZXzsJIRm[XSq M1HmRVIzPzh2M{[z
U87  MXTBdI9xfG:|aYOgRZN{[Xl? M{n3VVIx|ryP MWKyOIg> MWry[YR2[2W|IITo[UBieG:ydH;zbZMhemG2ZTDpcoR2[2WmIHL5JHBNSUJ? NGD1OWwzOjd5OEe4NC=>
HT1080 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnBZmhWPTEQvF2= MXm3[C=> MYXpcohq[mm2czD0bIUh[2WubDDndo94fGhiaX7obYJqfGmxbjDjZZV{\WRiYomgZ49u[mmwZXSgeJJm[XSvZX70JI9nKESFQTDhcoQhV02S MkjhNlI4PDB7OES=
A549  MmW4RZBweHSxc3nzJGF{e2G7 NUi5OmRmPTEQvF2= NFXUfJMzcA>? NEDMVJBx[XK2aXHscJkh\GWlcnXhd4V{KHOxZHn1cUB{\Wynbnn0[U1qdmS3Y3XkJIFxd3C2b4Ppdy=> NGLWZ2UzOjd{MUiwOC=>
Primary OPC MX;BdI9xfG:|aYOgRZN{[Xl? M1T0bVHPxE1? M{joe|ZpNzJ2aB?= M2LPbZJm\HWlZYOgeIhmKHCncnPlcpRi\2Vib3[gZ4VtdHNiaX6g[YFzdHlvIHHu[EBt[XSnLXHwc5B1d3Orcz;u[YNzd3Orcx?= NHvsdWozOjdyN{O4OS=>
PMNs M4DY[2Fxd3C2b4Ppd{BCe3OjeR?= M4HBfVQx|ryP Mki1Oog> M4XWVWROW09? M3XkT5JmfmW{c3XkJJRp\SCjbX;1cpQhd2ZiY3zlZZZm\CClYYPwZZNmNTNidH:gcoVieiC4ZXjpZ4xmKGyndnXsdy=> NF\NeZYzOjZ7MkW3Oy=>
A549  NWjpfXFNSXCxcITvd4l{KEG|c3H5 NETyc5k2OM7:TR?= Mne2NYg> M2DKe5Bz\X[nboTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KEKjb3j1c5Nq\GViSR?= M4\2dVIzPjh5NkO1
AGS NFvJSnpCeG:ydH;zbZMhSXO|YYm= M{nkflIx|ryP Mke5NVJp M4HnPYlvcGmkaYTzJJRp\SCjY4TpeoF1cW:wIH;mJJBzdy2lYYPwZZNmNTNiaX6gdoV{eG:wc3WgeI8hfGinIFX0U2FkKG[{YXP0bY9v M{fOUFIzPjh5M{m4
shC9  NHLCWJFCeG:ydH;zbZMhSXO|YYm= M3zFeFEx|ryP MXKxOog> NHHxe2RjdHWwdIOgV2hJKGW6cILld5Nqd25iaX6gd4hEQSClZXzsd{BmgHCxc3XkJJRwKGWrdHjldkBRSSCxcjDMVGM> MX[yNlY1OTB7NB?=
primary MEFs MWnGeY5kfGmxbjDBd5NigQ>? MoTVNVJp NUe4TnBVyqCrbnPy[YF{\XNiZYTvdI9{cWSnLXnu[JVk\WRibXn0c4Npd26mcnnhcEBu\W2kcnHu[UBl\XCxbHHybZpifGmxbh?= NXHGTYZ2OjJ4MUO3Olc>
3T9 MEFs Mk\iSpVv[3Srb36gRZN{[Xl? NYfDOo05OT[q Mk[zbY5kemWjc3XzJIN6fG:laILvcYUh[yC{ZXzlZZNmKGGodHXyJIV1d3Cxc3nk[U11emWjdH3lcpQ> M3HIS|IzPjF|N{[3
3T9 MEFs MWPGeY5kfGmxbjDBd5NigQ>? Ml;BNVhp NV3Vb5p1fXC{ZXf1cIF1\XNiaX7peIlifG:{IHPhd5Bie2VvOTDieZQh\G:5boLl[5Vt[XSnczDl[oZm[3SxcjDjZZNx[XOnczDh[pRmeiCndH;wc5Nq\GVidILlZZRu\W62 M4O5UVIzPjF|N{[3
MDA-MB-231  MVvBdI9xfG:|aYOgRZN{[Xl? NGH0V|EzOM7:TR?= NEfCfXY1\A>? M3\CWpJm\HWlZYOgeIhmKGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkhdWW2Zn;ycYlvKHS{ZXH0cYVvfCC5YYOgd4lodmmoaXPhcpRtgQ>? NF3UWVMzOjV7M{S0NS=>
C6  M2fDNWFxd3C2b4Ppd{BCe3OjeR?= NGjNRowyOM7:TR?= MVmyOIg> MYDicI9kc3NidHjlJJN2eHC{ZYPzbZZmKGWoZnXjeEBw\iC2aHWgdIVxfGmmZTDvckB3cWGkaXzpeJk> M1TyNlIzPTh6OUiw
HL-60  Ml;FRZBweHSxc3nzJGF{e2G7 MW[xNFDPxE1? Mkf6NlRp MXzpcohq[mm2czD0bIUh[2WubDDhdI9xfG:|aYOgd4Vt\WO2ZXSgLEsqNW2nboTofYwh|rJvKEJiirI3MS2maXfseYNweHm{YX7vd4ll\cLiNR?= M2rQWFIzPTR4Nk[5
HL-60 MnjiRZBweHSxc3nzJGF{e2G7 NXjnRZo3OTBvOEFOwG0> MlfxOIg> NWPlWFlucW6qaXLpeJMhXEeKUT3pcoR2[2WmIHPlcIwh[XCxcITvd4l{yqB? NILVR|UzOjV{M{KyPS=>
BCC M{PtRmFxd3C2b4Ppd{BCe3OjeR?= NXvVNZNRPTEQvF2= MVmxbC=> MoPKbY5pcWKrdIOgSGFVWy2vZXTpZZRm\CCpcn;3eIghcW6qaXLpeIlwdg>? M2\oWlIzPTF7NEO2
RAW 264.7 M3T0SmFxd3C2b4Ppd{BCe3OjeR?= MkftOVAwOTByzszN MkDpNYg> MnzDZ49v[2WwdILheIlwdi2mZYDlcoRmdnRiaX7obYJqfHNiRF;OMYlv\HWlZXSgdnJPSSClbHXheoFo\Q>? MWOyNlQ6OTR{Nh?=
K562 MVnBdI9xfG:|aYOgRZN{[Xl? MVSyOe69VQ>? Mmm2Nog> NVLMV|FoeHKndnXueJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3:teJJm[XSvZX70JJdqfGhiYX31doVve2mwIFegZY5lKFSUQVnM M3rITFIzPDh|N{e3
SGC-7901 NVvJNJZVSXCxcITvd4l{KEG|c3H5 Mn;mNlAh|ryPwrC= MUCybC=> MYPheJRmdnWjdHXzJGgzVzMEoH;yJHRPTiEQsT3pcoR2[2WmIHPlcIwh[XCxcITvd4l{KGG|IIflcIwh[XNiY3HzdIF{\S1|IHHjeIl3cXS7wrC= MlT0NlI1PzF3OEm=
PC3 NV3JXW03SXCxcITvd4l{KEG|c3H5 NGDoTFYyOM7:TR?= NH\VbnI1cA>? M1\FboNwfW62ZYLzJIZt[X[xY3;4bYQucW6mdXPl[EBk[XOyYYPlMZJmdGG2ZXSgZZBweHSxc3nz MV:yNlQ4OTl5NB?=
SMMC-7721 Mn;rRZBweHSxc3nzJGF{e2G7 NU\rUFRtPTEQvF2= MXu0PIg> MlXiZZR1\W63YYTld{BwXFJvaX7keYNm\CCjcH;weI9{cXN? MYeyNlQ3PTh|Mx?=
HeLa  MnWxRZBweHSxc3nzJGF{e2G7 M1fOdFUxyqEQvF2= MUC0M|hp NECyO|BqdmirYnn0d{BUXFNvaX7keYNm\CCuYYTlMZBp[XOnIHHwc5B1d3SrYzDleoVvfHN? NGGzTJozOjR4MEWwOC=>
HeLa  M1zrVmFxd3C2b4Ppd{BCe3OjeR?= MmXwOVDDqM7:TR?= M1;wfVFp MkLNd5VxeHKnc4Pld{B1cGViRmLBVE1qdmS3Y3XkJIFk[3WvdXzheIlwdiCxZjDhco5mgGmwIG[gdI9{cXSrdnWgZ4VtdHN? MYSyNlQ1QTR2MB?=
T47D  MXnBdI9xfG:|aYOgRZN{[Xl? MmnTNVAx|ryP MnrDNYg> NYe0PXVm[myxY3vzJJRp\SCpZX7ldoF1cW:wIH;mJGUu[2GmL1PUSlIh[nliU2TT NWrmdGs5OjJ2MEGxOlg>
HeLa  NEXkNIhCeG:ydH;zbZMhSXO|YYm= NHq2SVA{OM7:TR?= MXO0bC=> Mny0xsBqdmO{ZXHz[ZMhfGinIHflcoVz[WxiY3XscEB3cWGkaXzpeJkhPDhiaDDh[pRmeiCyaH;0c4R6dmGvaXOgeJJm[XSvZX70xsA> MXSyNlM6PDJ2OB?=
HCC NHHiR|NCeG:ydH;zbZMhSXO|YYm= MV:yNEDPxE4EoB?= NWDTfotUOmh? MYPheJRmdnWjdHXzJJRp\SCGSFGgbY5lfWOnZDDhZ5RqfmG2aX;uJI9nKFCDUmC= MljvNlI{PDJ5M{K=
mESCs M3;pb2Fxd3C2b4Ppd{BCe3OjeR?= NEWxcWozNjYQvF2= M1P3Z|Jp MojGbY5pcWKrdIOgeIhmKE6jRj3t[YRq[XSnZDDjZZNx[XOnIHHjeIl3[XSrb36= NX25XXFMOjJ{OEWyO|Q>
EMT-6  MWDDfZRwfG:6aXPpeJkhSXO|YYm= MlG3NVAx|ryP M4Pmb|Fp MVnwZZJ1cWGubImgZoxw[2unZDDj[YxtKGSnYYToJIlv\HWlZXSgZpkhe2m{YX3ld4lv\Q>? M{T0Z|IzOjVzOUKx
MCF7 M2[3SWFxd3C2b4Ppd{BCe3OjeR?= M2DLOFUxyqEQvF2= NUWxe3MxOWh? MoTsbY5pcWKrdIOgVGEh[WO2aY\heIVlKGOjc4Dhd4UuOyxiLUmsJIFv\CCyb3z5LGFFWC2{aXLvd4UqKHCxbInt[ZJie2V? Mkm0NlIzOjN|NEW=
K562 M1XNeWFxd3C2b4Ppd{BCe3OjeR?= NU[xZ3hMOjBizszNxsA> MkPlOFhp MofmSG1UVw>? NEjpSpBjdG:la4OgcIFx[XSrbnniMYlv\HWlZXSgbY5pcWKrdHnvckBw\iC4aXHibYxqfHliYX7kJIFxd3C2b4Ppd{BqdmS3Y4Tpc44> MnLvNlIzOTZzNUi=
Molt4-hyg MXLBdI9xfG:|aYOgRZN{[Xl? NYLaTo9iOTEQvF2= Mme5NE42cA>? NFy3d4hjdG:la4Og[oFzdmW|b3ytbY5lfWOnZDDjZZNx[XOnLUOtcIls\SCjY4Tpeol1gQ>? MUWyOlI4PThzMR?=
HeLa NXqzV5hMSXCxcITvd4l{KEG|c3H5 Moq0NVDPxE1? NYLvcmlmOC53aB?= M2L4S4lvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KHSqZTDjc41jcW6nZDD0doVifG2nboSge4l1cCCpb33pd4lvKE5iYX7kJHRTSUmO MmfFNlIyPzl4NkG=
Jurkat T Mn[4RZBweHSxc3nzJGF{e2G7 NWDkdINrOzEQvF2= M{ftNVAvPWh? MlTFSG1UVw>? M2L4cYJtd2OtczD0bIUhgmm{YX2tbY5lfWOnZDDhdI9xfG:|aYO= M2LOcVIzOTV7OEm4
Neutrophil MULBdI9xfG:|aYOgRZN{[Xl? NXW2TXRjOjEQvF2= M4jOVVAvPWh? MoLqZZR1\W63YYTld{B1cGVicILvMYFxd3C2b4TpZ{Bm\m[nY4Sgc4YhVWGUMR?= NFfBOIMzPjF7Nki0OC=>
HCT116 NWfNWo4{SXCxcITvd4l{KEG|c3H5 NWfLc2xYPTEEoN88US=> MlW4Nog> M3PnNZJmfmW{c3XzJJN6dmW{Z3nzeIlkKGGyb4D0c5NqeyCnZn\lZ5R{KG:oIHPlcIVkd3irYjDhcoQhVlCFLUG2xsA> MmTzNlIyPTl5NUK=
MDA-MB-231  MUnBdI9xfG:|aYOgRZN{[Xl? NWDhUWVIOi53LUeuOe69VQ>? NXf5VldvOmh? NFf3RWhqdmirYnn0d{B1cGViY3XscEBl\WG2aDDv[kBOTEFvTVKtNlMyKGOnbHzzJIlv\HWlZXSgZpkhW0SWIHnuJIEh[2:wY3XueJJifGmxbjDk[ZBmdmSnboSgcYFvdmW{ NF\ES5gzOjFzNUWyOi=>
LNCaP NYP1Nm9VSXCxcITvd4l{KEG|c3H5 Mlz5OFDPxE1? NEfGZ3IzcA>? NIfWeWZqdmirYnn0d{BjfXSnaX6gbY5lfWOnZDDj[YxtKGGyb4D0c5Nqew>? NHHFTGYzOjFzNEe2OC=>
MB231 MXHBdI9xfG:|aYOgRZN{[Xl? NH\pb4IyODEQvF2= MUCxbC=> NH;1e25FVVOR MXPhZpJw\2G2ZYOgeIhmKGmwZIXjeIlwdiCxZjDj[YxtKGSnYYToJIJ6KFeHRUGgbY5pcWKrdHnvckwhXFKDSVygeJJm[XSvZX70MEBidmRidHjlJINwdWKrbnH0bY9v MYCyNlEyOjl2MB?=
HCC38  NH3HVJlCeG:ydH;zbZMhSXO|YYm= Ml7rNVAx|ryP NXHheY5XOWh? M3XnfWROW09? NGHxb3Ji[nKxZ3H0[ZMhfGinIHnu[JVkfGmxbjDv[kBk\WyuIHTlZZRpKGK7IGfFSVEhcW6qaXLpeIlwdixiVGLBTWwhfHKnYYTt[Y51NCCjbnSgeIhmKGOxbXLpcoF1cW:w NInDdG4zOjFzMkm0NC=>
MDA-MB231 NWfkNYtnSXCxcITvd4l{KEG|c3H5 NXO5SIo5PTEEoN88US=> NVTx[|JZOjSq NUPtWW9HTE2VTx?= M1zmfoFjem:pYYTld{BkfXKldX3pck1qdmS3Y3XkJINmdGxiZHXheIg> NY\sSWpkOjJzMEGzN|U>
LNCaP M1T5cGFxd3C2b4Ppd{BCe3OjeR?= M3LRSVUxyqEQvF2= MkDTNlRp NVm1bJdZTE2VTx?= Mk\0ZYJzd2ejdHXzJIN2emO3bXnuMYlv\HWlZXSgZ4VtdCCmZXH0bC=> MlLHNlIyODF|M{W=
HCT116 NUfkboc3SXCxcITvd4l{KEG|c3H5 M2nPeVUxyqEQvF2= MYGyOIg> MVLEUXNQ M171UYFjem:pYYTld{BkfXKldX3pck1qdmS3Y3XkJINmdGxiZHXheIg> MlmyNlIyODF|M{W=
Ishikawa  NIezNWdCeG:ydH;zbZMhSXO|YYm= MUWyOe69VQ>? M2\uPVI1cA>? MoGwdoVlfWOnczDj[YxtKGSnYYToJIFv\CCjcH;weI9{cXNiaX7keYNm\CCkeTDCZYYhSTF? NGDsb5QzOjB6OEmxPC=>
 YD-8  NYizTpc6SXCxcITvd4l{KEG|c3H5 MmXzNVAx|ryP MojiNYg> MX\pcohq[mm2czDQUGVQNWmwZIXj[YQh[XCxcITvd4l{ MXqyNlA5PjF6Mx?=
eosinophil  NHH5e2NCeG:ydH;zbZMhSXO|YYm= NFnET|k6OM7:TR?= NYjOUldDOjSq MVPpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBH[XNiYX70bYJw\HoEoB?= M4[4fVIzODd7M{O0
L929 MnXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPtZ3hqOi53zszN NXjTVZA4OjSq MWTpcohq[mm2czD0bIUh\XiycnXzd4lwdiCxZjDwMZA{QCCjbnSgUmYu|rqEIITvJIF2\22nboSgWG5H|rFvaX7keYNm\CCwZXPyc5B1d3OrczDhcoQh[XW2b4DoZYd6 NVPxTlhyOjJyMkewPVc>
YD-8  M{PEWmFxd3C2b4Ppd{BCe3OjeR?= NFGze3kyODEQvF2= NInqeG4ycA>? Ml;6Zoxw[2u|IITo[UBIWy2KQ3ytbY5lfWOnZDDhdI9xfG:|aYO= NVfSXo5mOjJyMkCwO|g>
HBx NX3pW5Z5SXCxcITvd4l{KEG|c3H5 NGPiOWwzPc7:TR?= Mn\UOFhp M1;RXmROW09? M3Li[pJm\HWlZXSgZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KDNvTVG= MnTXNlIxOjByN{i=
U937  MUTBdI9xfG:|aYOgRZN{[Xl? MVm1NOKh|ryP NYjPflluOWh? NU\COm5jcW6qaXLpeJMhUEZvaX7keYNm\CCjcH;weI9{cXQEoB?= NV[0UpN2OjF7OUi3N|E>
HL60 MmX0RZBweHSxc3nzJGF{e2G7 NV;sXFdYPDEQvF2= NEHwSGo1OG2rbh?= MX;EUXNQ NVPSOI1U[myxY3vzJGJPTENiY3;tdI92dmS|IHnu[JVk\SCneIDvd5Vz\SCxZjDwbI9{eGijdHnkfYx{\XKrbnWgZY5lKESQQTDmdoFodWWwdHH0bY9v NWrzfnE2OjF7OEOyPVY>
M-14 M2HJSWFxd3C2b4Ppd{BCe3OjeR?= NHrPZVczPc7:TR?= MlnUNE42cA>? M3m4SeKhcW6qaXLpeJMh[m:2aDD0bIUh[3K3ZHWg[Zh1emGldD2gZY5lKGOxbYDveY5lNWmwZIXj[YQh[XCxcITvd4l{ MkmxNlE6PTR7NUm=
SK-BR-3 MkmwRZBweHSxc3nzJGF{e2G7 MorIOVDDqM7:TR?= MnHCNog> NHHQd5BjdG:la4OgZZBweHSxdHnjJGRPSSCocnHncYVvfGG2aX;uJIlv\HWlZXSgZpkh[2:vYnnuZZRqd25ib3[gV20uOTZ2IHHu[EBz[WSrYYTpc44> NFvIZpkzOTlyMUO4Oi=>
MDA-MB-468 NFXqfJJCeG:ydH;zbZMhSXO|YYm= MnPIOVDDqM7:TR?= M1KwZ|Jp NVnPNI43[myxY3vzJIFxd3C2b4TpZ{BFVkFiZoLh[41mdnSjdHnvckBqdmS3Y3XkJIJ6KGOxbXLpcoF1cW:wIH;mJHNONTF4NDDhcoQhemGmaXH0bY9v M{T3W|IyQTBzM{i2

... Click to View More Cell Line Experimental Data

体内研究 有研究表明,体内Z-VAD-FMK的给药不具有毒性,在动物模型中可抑制凋亡。在小鼠中,腹腔注射HK-GBS可引起早产,而预处理以Z-VAD-FMK可延迟早产现象。在OVA-sensitized的小鼠中,z-VAD-fmk的处理可抑制过敏原诱导的白细胞浸润。在OVA致敏前全身性注射z-VAD-fmk可减少OVA-sensitized/challenged小鼠中炎性细胞的积累、黏液的高分泌以及Th2细胞因子的释放。处理以z-VAD-fmk可阻止晶状体上皮细胞、角质细胞的终末分化;单核细胞向巨噬细胞的分化;以及红系造血祖细胞的分化。z-VAD-fmk可减缓过敏原诱导的呼吸道炎症以及高敏性、阻止后续T细胞的激活[7]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[6]

+ 展开
  • Cell lines: 颗粒细胞GC1a, HGL5, COV434
  • Concentrations: 50 μM
  • Incubation Time: 48 h
  • Method:

    为了确定Z-VAD-FMK的效力,在常氧条件下,用etoposide (50 μg/ml) 和/或 Z-VAD-FMK (50 μM)对三种人源颗粒细胞系(GC1a, HGL5, COV434)进行处理,处理48小时。为了模拟卵巢片段抑制后的缺氧状态,用低氧(1% O2)状态下,用无血清培养基培养细胞,处理以Z-VAD-FMK。用WST-1试验检测细胞的代谢活性。通过FACS检测细胞活力,RT-qPCR和WB检测凋亡相关分子的表达。


    (Only for Reference)
动物实验:

[7]

+ 展开
  • Animal Models: CD1小鼠
  • Formulation: 溶解于DMSO,用PBS进行稀释,最终DMSO浓度小于1%
  • Dosages: 10 mg/kg
  • Administration: i.p.
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 93 mg/mL (198.93 mM)
Water Insoluble
Ethanol Insoluble warmed
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+35 %PEG 300+2%Tween 80+ddH2O
6mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 467.49
化学式

C22H30FN3O7

CAS号 187389-52-2
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    Can you suggest an in vivo formulation of S7023 for animal studies?

  • 回答:

    For in vivo study of S7023, The IP formulation is 2% DMSO+35 % PEG 300+2% Tween 80+ddH2O up to 6 mg/ml. The gavage formula is 1%CMC-Na up to 30 mg/ml (suspensions).

  • 问题 2:

    What is difference between S7023 & S8102?

  • 回答:

    Unlike S7023, S8102 does not require pretreatment with esterase for in vitro studies. This information was cited from the article: https://www.ncbi.nlm.nih.gov/pubmed/16973565.

Caspase Signaling Pathway Map

相关Caspase产品

Tags: 购买Z-VAD-FMK | Z-VAD-FMK供应商 | 采购Z-VAD-FMK | Z-VAD-FMK价格 | Z-VAD-FMK生产 | 订购Z-VAD-FMK | Z-VAD-FMK代理商
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID