Z-VAD-FMK

目录号:S7023

Z-VAD-FMK Chemical Structure

Molecular Weight(MW): 467.49

Z-VAD-FMK是一种细胞渗透性的,不可逆泛caspase抑制剂,在THP.1 和 Jurkat T细胞中阻断细胞凋亡的所有特性。

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RMB 962.65 现货
RMB 3841.92 现货
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客户使用Selleck该产品发表文献22篇:

客户使用该产品的8个实验数据:

  • (A) LAN5 cells were untreated (top panels) or treated with 50 µM of the caspase inhibitor Z-VAD-FMK (bottom panels). Cells were co-treated with nothing (No Rx), 1 µM GSK-J4, or 1 µM venetoclax for 48 hours and assayed for apoptosis by flow cytometry.

    Science, 2018, 10(441), doi: 10.1126/scitranslmed.aao4680. Z-VAD-FMK purchased from Selleck.

    HepG2 cells were pretreated with Z-VAD-FMK for 2 hours followed by treatment with IsoA for 16 hours, and the apoptotic cells were evaluated and quantified by Annexin V/7-AAD staining and flow cytometry. The mean±SD of three experiments is shown.***, P < 0.001

    Cancer Res, 2017, 77(4):926-936. Z-VAD-FMK purchased from Selleck.

  • MM.1S cells were incubated with or without pan-caspase inhibitor Z-VAD-FMK for 1 h and then treated with DCZ3301 (4 μM) for 48 h followed by assessment of cell apoptosis using Annexin V/PI staining. Columns (right panel) represent the average percent of Annexin V positive cells from three independent experiments, which are shown as the mean±SD.

    Theranostics, 2017, 7(15):3690-3699. Z-VAD-FMK purchased from Selleck.

    After treatment with 1.5 g/l matrine in the presence or absence of 10 nM Baf A1 or 20 nM rapamycin or 10 lM z-VAD-FMK (zVAD) for 24 hrs, the cell viability was measured by CCK-8 assay. Results were expressed as mean±S.E.M. representing at least three independent experiments. *P < 0.05, versus matrine alone group.

    J Cell Mol Med, 2017, 21(6):1171-1181. Z-VAD-FMK purchased from Selleck.

  • Z-VAD-FMK (ZVF) reversed K562 cell apoptosis induced by imatinib (IM) and/or hUC-MSCs-Exo. **P < 0.01 versus K562 + IM group, ##P < 0.01 versus K562 + IM + hUC-MSC-Exo group.

    Cytotherapy, 2018, 20(2):181-188. Z-VAD-FMK purchased from Selleck.

    (A and B) Western blot analysis examining the effect of zVAD-fmk on the icaritin-induced apoptosis. The caspase inhibitor zVAD-fmk could significantly decrease the icaritin-induced cleaved caspase-3 expression. β-Actin protein levels indicate that an equal amount of protein was loaded into each lane.n=3. Mean±SD. bP<0.05, compared to the control group. eP<0.05, compared to the icaritin-treated group.

    Acta Pharmacol Sin 2014 35(4):531-9. Z-VAD-FMK purchased from Selleck.

  • Active caspase-3 expression analysis. SW1116 cells were treated with ZBH-1205, CPT-11 and SN38 at 25 μmol/L for 48 h, in the presence or absence of Z-VAD-FMK (50 μmol/L, 1 h ahead of time). *P= 0.0345. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). E: Cell cycle analysis. F: Apoptosis analysis. #P=0.0259. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). ALL experiments were repeated three times.

    Arch Biochem Biophys, 2016, 604:74-85.. Z-VAD-FMK purchased from Selleck.

    Effect on the RAS of CFZ, z-VAD-fmk, or CFZ + z-VAD-fmk treatments administered 5 or 12 days after C26 inoculation and control groups. Western blot analysis of ATF2 and pATF2. CP, ZP and UP were treated for 5 days; CT, ZT, UT and CC were treated for 12 days. CFZ (CP), z-VAD-fmk (ZP), CFZ + z-VAD-fmk (UP), PBS only (CC), healthy control (HC).

    Med Oncol, 2015, 32(4): 538 . Z-VAD-FMK purchased from Selleck.

产品安全说明书

Caspase抑制剂选择性比较

生物活性

产品描述 Z-VAD-FMK是一种细胞渗透性的,不可逆泛caspase抑制剂,在THP.1 和 Jurkat T细胞中阻断细胞凋亡的所有特性。
特性 Z-VAD-FMK是研究细胞凋亡的一种关键化合物。
靶点
Pan-caspase [1]
(THP.1, Jurkat T-cells)
体外研究

Z-VAD-FMK(10 mM)作用于THP.1细胞,抑制细胞凋亡。Z-VAD-FMK(10 μM)作用于THP.1细胞裂解液,抑制PARP蛋白酶活性的激活。Z-VAD-FMK(10 mM)作用于完整THP.1和 Jurkat细胞,抑制CPP32加工。[1]Z-VAD-FMK(50 μM)与Camptothecin共处理HL60细胞,废除Camptothecin处理的细胞凋亡形态。Z-VAD-FMK(50 μM)作用于HL60细胞,抑制Camptothecin诱导的DNA分裂。[2]Z-VAD-FMK (50 μM)作用于S2细胞,提高转染细胞的生存百分数从26%提高到63%。[3]Z-VAD-FMK(>100 μM)作用于人类嗜中性粒细胞,增强TNFα-诱导的中性粒细胞凋亡,较低浓度(1-30 μM)时完全抑制TNFα刺激的细胞凋亡。[4]Z-VAD-FMK (10 mM) 作用于早期角膜基质细胞,抑制细胞凋亡。[5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GC1a MVPBdI9xfG:|aYOgRZN{[Xl? NFr3[Yw2OM7:TR?= M4jwSFI1cA>? MUjpcoRq[2G2ZYOgZUBxem:2ZXP0bZZmKGWoZnXjeEBi\2GrboP0JIV1d3Cxc3nk[S=> NH:2fG8zPjF4OUC3OS=>
HGL5 MoG1RZBweHSxc3nzJGF{e2G7 MX61NO69VQ>? M1qz[|I1cA>? M2XTeolv\GmlYYTld{BiKHC{b4TlZ5RqfmViZX\m[YN1KGGpYXnud5Qh\XSxcH;zbYRm MorTNlYyPjlyN{W=
HepG2 MnrKRZBweHSxc3nzJGF{e2G7 MoLYNlDPxE1? NVW4dHN1OWh? NH\MXWhifHSnboXheIVlKHSqZTDhdI9xfG:2aXOgbY5lfWO2aX;uJI9nKEmLST2xNOKh NX;rOo9FOjZzNkS3PVU>
BEL-7402 MnrIRZBweHSxc3nzJGF{e2G7 M{GzTFIx|ryP M4PQUlFp MlrCZZR1\W63YYTl[EB1cGViYYDvdJRwfGmlIHnu[JVkfGmxbjDv[kBKUUlvMUFCpC=> MVeyOlE3PDd7NR?=
CEF NGjvXoNMcW6jc3WgRZN{[Xl? M2fxOlAtOzNuNkesNVAx|ryP NILoZ|AyPW2rbh?= NIPKbmlld3ewLYLl[5Vt[XSnczDQVkBmdnq7bXWgZYN1cX[rdImgeI8hPDExvJWgZZQhOTByzszN NX\pblJEOjZzMEKzN|k>
SP2/0 MlX6RZBweHSxc3nzJGF{e2G7 MVexNFDPxE1? NVLkZVhQOWh? NHjJfVBFVVOR MX7icI9kc3NidHjlJIFxd3C2b4Ppd{Bw\iCVUEKvNEBk\Wyucx?= NHHW[mYzPjB5NEezNi=>
HUVEC-2c M{jCNGFxd3C2b4Ppd{BCe3OjeR?= MVK1NO69VQ>? MnLqOog> NGq0eI1l\WO{ZXHz[YQhfGinIH;4MWxFVC2rbnT1Z4VlKGG3dH;wbIFogQ>? Mlu5NlYxOjF5Mkm=
U1 MWXBdI9xfG:|aYOgRZN{[Xl? NHHKVnExNTFyMN88US=> NIqyTYUzcA>? MV;y[YR2[2W|IHTyeYcucW6mdXPl[EBieG:ydH;zbZMh[W6mIIP1ZpNmeXWnboSgTGlXNTFicnXwcIlk[XSrb36gbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= M2\rdFI2QThyOUSy
ACH-2 M4DtW2Fxd3C2b4Ppd{BCe3OjeR?= MoD4NE0zODEQvF2= MkDjNog> MlLMdoVlfWOnczDkdpVoNWmwZIXj[YQh[XCxcITvd4l{KGGwZDDzeYJ{\XG3ZX70JGhKXi1zIILldIxq[2G2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy MX[yOVk5ODl2Mh?=
U1 NF3zWW9McW6jc3WgRZN{[Xl? MVexNFDPxE1? Mm\hNog> M{POWolvcGmkaYTzJINie3Cjc3WtNy=> NGrrdnczPTl6MEm0Ni=>
A549/V16 MVrBdI9xfG:|aYOgRZN{[Xl? NULBO|Z7PTEQvF2= NWfvW2tZOWh? MX;y[ZBz\XO|ZYOgWGcwXE1vaX7keYNm\CCjcH;weI9{cXN? NXe1d5FYOjV7NE[wN|M>
SGN Ml30RZBweHSxc3nzJGF{e2G7 MYOyNI1O Mlq4OFhp NWPZOmtRcGG|IH7vJIlv\my3ZX7j[UBwdiCDSV[sJINidHCjaX6g[ZhxemW|c3nvckBweiClZXzsJIFxd3C2b4Ppdy=> NFHDTmozPTh5NE[zNy=>
HCT116  Mn:wRZBweHSxc3nzJGF{e2G7 MXS1NO69VQ>? Ml7sNog> Mn:2bY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiaX7keYNm\CCkeTDESHZR NVPlUnk3OjV6Nki4NVg>
DTK-SME MkXQRZBweHSxc3nzJGF{e2G7 NWnUeW52PTEQvF2= MnHDNog> NIrUWm1FVVOR MnrxdIFzfGmjbHz5JIlvcGmkaYTzJJRp\SCjcH;weI9{cXNiaX7keYNm\CCkeTDieZBqfmGlYXnu[S=> NGG1R40zPTh2M{i5Oy=>
HL-60 MVnBdI9xfG:|aYOgRZN{[Xl? NVG0c3BSPTEQvF2= M1\OdFQ5cA>? MYTy[YR2[2W|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JHNMUS2LSTD0doVifG2nboVCpC=> MkfvNlU5OjRyNEO=
U937 NYnEVXZoSXCxcITvd4l{KEG|c3H5 MUS1NO69VQ>? M{XYUVQ5cA>? M3XnRZJm\HWlZYOgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhW0uLLVnJJJRz\WG2bXXueOKh M4PpVFI2QDJ2MESz
A549 NV;TWmxKSXCxcITvd4l{KEG|c3H5 M4TUd|IxKM7:TR?= M{XCR|I1cA>? M323PJJm\HWlZYOgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhUE[FUDD0doVifG2nboS= Mm\nNlU4QTRzNEm=
HeLa NVX0WZZJSXCxcITvd4l{KEG|c3H5 MVGxNO69VQ>? M2TuVFQ5cA>? MlG1[IVkdGmwZYOgeIhmKHKjdHWgc4Yh[XCxcITvd4l{KGS{YX3heIlk[WyueR?= NIjCclkzPTd5MkW0OS=>
SGC-7901 NWOyNJY1SXCxcITvd4l{KEG|c3H5 NWfVOXhqOjEEoN88US=> MVmxbC=> NWjTSJFXcW6qaXLpeJMhfGinIHPlcIwh\GWjdHigbY5lfWOnZDDifUBwgGGuaYDsZZRqdg>? MWKyOVc3PzB5Nh?=
MCF-7 NHjyOGdCeG:ydH;zbZMhSXO|YYm= MV2xNO69VQ>? NEKyd4IzcA>? MkjxbY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiaX7keYNm\CCkeTCzRi=> M4rRTVI2PzJ{MUG0
A549 M1nYXWFxd3C2b4Ppd{BCe3OjeR?= NHTaZZkyOCEQvF2= MnP0NlRp M3L0eWROW09? NEnaWW9xem:vb4Tld{BJSkNvdILlZZRm\CCDNUS5JINmdGxic4Xyeol3[WxiJjDheJRmdnWjdHXzJJRp\SClbHXheoVlKFCDUmCg[ZhxemW|c3nvci=> NX71NYpEOjV4OEO1Olg>
U87 NWLrT|ZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXq1NO69VQ>? MlTINYg> MkTQdoVkd3[ncoOgZ4VtdCCpcn;3eIgh\nKxbTDUUXohfHKnYYTt[Y51 NELzeWczPTZ6MU[2PC=>
Neocortical Neuron M1;QN25mfXKxdH;4bYNqfHliQYPzZZk> M1zNd|ExOM7:TR?= MXOxbC=> MYPhcpRi\2:waYrld{BJd2mjbXnk[UBCNUmwZIXj[YQhVmW3cn;0c5hq[2m2eR?= NIGyWW0zPTZ5NUCwNS=>
Primary human placental cytotrophoblasts M2nNXGFxd3C2b4Ppd{BCe3OjeR?= NH\oUo0{OM7:TR?= MmP4NlRp MWPEUXNQ NFyxTI1z\X[ncoPld{B1cGViaX7obYJqfGmxbjDv[kAyOc7{LVjTSFIh[nlidILpZ4xwe2GwwrC= Ml;TNlU3PDJ3OUK=
MM M4DqTmFxd3C2b4Ppd{BCe3OjeR?= NEXqXFQ2OM7:TR?= M4DKSVIxdWmw M{fTWJBienSueTDpcohq[mm2czDTTGsucW6mdXPl[EAh[2WubDDk[YF1cA>? M1jzT|I2PTNyMEm4
DLD1 M2jZR2Fxd3C2b4Ppd{BCe3OjeR?= NGPtfZAzOMLizszN MUCxbC=> M3\KZ5BienSueTDy[ZZmenOnczDj[YxtKGGyb4D0c5NqeyClYYXz[YQh[nliV2PQNS=> MWWyOVUzPDJ2Nh?=
MDA-MB-231 M3;xbmN6fG:2b4jpZ4l1gSCDc4PhfS=> NYrrZ4JZOTEQvF2= M1:zbVFp MV3heYdu\W62czDj[YxtKGSnYYToJIFnfGW{IFPIWWEhfHKnYYTt[Y51 NHXBfYIzPTV{MUWwNS=>
MKN28 NF:1[IZCeG:ydH;zbZMhSXO|YYm= M3rzV|Ex|ryP MXuzNI1qdg>? NELmSVFFVVOR NHW5RZJqdmirYnn0d{BVVkZvzsGgdIx2eyCFSGitbY5lfWOnZDDhdI9xfG:|aYO= M4XRfVI2PTF|OU[w
HL-60 NXHrbZgzS3m2b4TvfIlkcXS7IFHzd4F6 M{n5PFExOM7:TR?= MUOxbC=> M2HzT2ROW09? NID3dnbDqGmvcILveoV{KH[rYXLpcIl1gSCxZjDUR25Cey22cnXheIVlKGOnbHzz NIToOXozPTVyMkmzNi=>
AGS NUXkSVJySXCxcITvd4l{KEG|c3H5 M{DLbVEx|ryP MmO3NYg> M{jOSpBz\X[nboTzJIN2emO3bXnuMYlv\HWlZXSgZ4xm[X[jZ3Wgc4Yh[2G|cHHz[U0{NCBvODygZY5lKC17IIDyc5RmcW6| NV7scGFSOjV2OUKyNVQ>
A549  MVjBdI9xfG:|aYOgRZN{[Xl? M2fQ[VEx|ryP MWqyOIg> M{[zPIJtd2OtczDEUWFUNWmwZIXj[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHHu[EBieG:ydH;0bYMh[2WubDDk[YF1cA>? MXOyOVQ{PDl6OR?=
INS-1 MknrRZBweHSxc3nzJGF{e2G7 NYOyWG1VPTEQvF2= MnnNOog> MXfEUXNQ MYPk[YNz\WG|ZYOgeIhmKHC{b4DvdpRqd25ib3[g[YFzdHliYYDvdJRwfGmlIHPlcIx{yqB? NGX1Z2EzPTR|MEi5Oy=>
Primary hepatocytes  MXnBdI9xfG:|aYOgRZN{[Xl? MXK1NO69VQ>? M2GyTVE5cA>? NVvuR21OcW6qaXLpeJMh[XCxcITvd4l{KG:oIHjldIF1d2O7dHXzJIlv\HWlZXSgZpkhSWO2IFSgZY5lKFSQRj5OtS=> NFfFV|YzPTRyN{WzPC=>
L929-A  NUSzNnBZS3m2b4TvfIlkcXS7IFHzd4F6 Mkj3NlDDqM7:TR?= NUPnOWZ2OjSq NYfkephPcW6qaXLpeJMhXE6IzsGtbY5lfWOnZDDj[YxtKGSnYYTo MUSyOVM6QDV2MB?=
L929-N NYPOUXVNS3m2b4TvfIlkcXS7IFHzd4F6 NV7QZ4dtOjEEoN88US=> NYr3XXdUOjSq NFyxc3dmdmijbnPld{Bl\WG2aDD2bYEh[XW2b3PybY5mKFSQRt8xJJBzd2S3Y4Tpc44> NW\ucFV1OjV|OUi1OFA>
Cytotoxicity Assay M2e0fWNmdGxiVnnhZoltcXS7IFHzd4F6 NHTXN2YzOM7:TR?= M2fER|Q5cA>? MkLSdJJmfmWwdDDNTG1FNWmwZIXj[YQh[2WubDDk[YF1cA>? M4\UdVI2Ozl{MUG2
COS7 MYDLbY5ie2ViQYPzZZk> MWmxNO69VQ>? MWiyOIg> Mn\ObY5kemWjc3XzJINie3Cjc3WgN{84KGGldHn2bZRq\XN? Mn3vNlU{QDRyMkW=
COS7 MWTBdI9xfG:|aYOgRZN{[Xl? NFLue2gyOM7:TR?= NEO4UFg1QGh? MmXqdIFzfGmjbHz5JJBz\X[nboTl[EBHSzFyMT3pcoR2[2WmIHPlcIwh\GWjdHi= MYiyOVM5PDB{NR?=
A375 MXPBdI9xfG:|aYOgRZN{[Xl? NYDzeXlnOzEQvF2= NYjuVHdiOmh? MlnidJJmfmWwdIOgeIhmKGS{dXetbY5lfWOnZDDQRXJRKGOuZXH2ZYdm M17X[FI2Ozd4MUG1
A549 NFjtVYZCeG:ydH;zbZMhSXO|YYm= M3vHXFUx|ryP MoOzNlRp MVry[ZZmenOnczDybYJwe2:vZTDibY9o\W6nc3nzJIFv\CCjcH;weI9{cXNiY3H1d4VlKGK7IDDDbIlrd26pZHHu MVeyOVM1QTd6MR?=
A549 MljqRZBweHSxc3nzJGF{e2G7 M3f2W|IvPS1{Nd88US=> MkLZNYg> MUjk[YNz\WG|ZYOgeIhmKHCxcIXsZZRqd25ib3[gZZBweHSxdHnjJINmdGy|IHTldIVv\CCxbjDjc45k\W62cnH0bY9vew>? MXKyOVM1OjR{Nx?=
 NBL-W-S  M3XGZ2Fxd3C2b4Ppd{BCe3OjeR?= M1XvVFUx|ryP NEmxflgycA>? MVzmeYxtgSC{ZYPjeYV{KGOnbHygeoli[mmuaYT5JIFnfGW{IFfBUnQuPjFidILlZZRu\W62 NH\wdlYzPTN{M{KyNi=>
Caki-1  NXK5XJdJSXCxcITvd4l{KEG|c3H5 NFu4bHQ1OM7:TR?= MknqOFhp MY\y[YR2[2W|IITo[UBvfW2kZYKgc4YhSW6wZYjpckBXNXCxc3n0bZZmKGOnbHzz M{PZN|I2Ojd7MUmx
769-P MlzFRZBweHSxc3nzJGF{e2G7 MoTUOFDPxE1? M1jBSFQ5cA>? MUfy[YR2[2W|IITo[UBvfW2kZYKgc4YhSW6wZYjpckBXNXCxc3n0bZZmKGOnbHzz M{CxflI2Ojd7MUmx
H9c2 NVLjXJBKSXCxcITvd4l{KEG|c3H5 M4LjVlUx|ryP M1LXVlFp MlrhbY5pcWKrdIOgSG9ZNWmwZIXj[YQh[2G|cHHz[UA{KGGldHn2ZZRqd25iYoX0JI5wfCC2aHWgcI9{eyCxZjDj[Yxtew>? NWnqe297OjV{OEO4NVk>
K562 MmXhRZBweHSxc3nzJGF{e2G7 M4nuOFUx|ryP NIrjTHc1cA>? MUjpcohq[mm2czDKZYMuSS2rbnT1Z4VlKGOnbHygZZBweHSxc3nz NYnIbIp[OjV{NEG2NVk>
L929 NHnBfZBCeG:ydH;zbZMhSXO|YYm= MkXuNVDPxE1? NFfUclg3cA>? MYPpcoR2[2W|IH7lZ5JweHSxc3nzJJdqfGhiVF7G NEPnUFUzPTF7NU[2NC=>
A549 NXnN[VJESXCxcITvd4l{KEG|c3H5 NVnYUnZ5OTEQvF2= MUOzbC=> MUjy[YR2[2W|IHPlcIwh[XCxcITvd4l{KGOjdYPl[EBjgSCSUWG= NHfjeW4zPTF4MU[5PS=>
MCF-7 NGjrRYxCeG:ydH;zbZMhSXO|YYm= NI[4SoczOM7:TR?= NYezXGJoOmh? MXLk[YNz\WG|ZYOgT2RTNXOrUl7BMYlv\HWlZXSgZZBweHSxc3nz MnXMNlUyQDJ{NEC=
OS NYi4dG5sSXCxcITvd4l{KEG|c3H5 MonzNlAwPDEQvF2= MUS3Nog> M2\oUolvcGmkaYTzJG9UKGOnbHygeoli[mmuaYT5JJJm\HWldHnvckBjgSCFNjDj[ZJidWmmZR?= NI\XcFIzPTF3MkO5PS=>
HUVECs MmTxRZBweHSxc3nzJGF{e2G7 Ml;LNVDPxE1? M4PudVJp M4\jUOKhcW6qaXLpeJMh[XCxcITvd4l{KGGwZDDmZYNqdGm2YYTld{BifXSxcHjh[5khcW5iRFXOWlIucW6oZXP0[YQhUFWYRVPz Mn;yNlUyOzh5MEO=
EA.hy926 MYLBdI9xfG:|aYOgRZN{[Xl? NG[2TZoyOM7:TR?= NWDwR3pnOmh? MVlCpIlvcGmkaYTzJIFxd3C2b4Ppd{BidmRiZnHjbYxqfGG2ZYOgZZV1d3CqYXf5JIlvKESHTm[yMYlv\mWldHXkJGVCNmi7OUK2 M2jSUlI2OTN6N{Cz
Ebs NETYTGZCeG:ydH;zbZMhSXO|YYm= MY[xNE0yODEQvF2= NH21dGQzPGh? NE\6eVXDqE2PVGOg[4Vv\XKjdHnvckBz[XSnIHTlZ5Jm[XOnZDDhd{B1cGViY3;uZ4VvfHKjdHnvckBw\iC8LW\BSE5ndWtiaX7jdoVie2Wm MUWyOVE{PDhzNx?=
Jurkat MXXBdI9xfG:|aYOgRZN{[Xl? MnPKNlDPxE1? MVWyOIg> MX;EUXNQ NVXqUmc1eGG{dHnhcIx6KGmwaHnibZQh[2WubDDk[YF1cCCxZjDKeZJs[XRiY3XscJMhcW6mdXPl[EBjgSBzMEC1PE1HPCClb33ibY5m\CC5aYToJHZRScLi NYjlZ4wyOjVzMkC3NlM>
K562 M2C0cWFxd3C2b4Ppd{BCe3OjeR?= NHjyNJIxNjFvMd88US=> MXqxbC=> NVni[ndZcW6qaXLpeJMh[2ynYY\h[4Uhd2ZiSGPQPVAhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NHXwPVEzPTFzOUG4PC=>
IMR-32 MoHzRZBweHSxc3nzJGF{e2G7 MmPYOFDDqM7:TdMg MX6ybC=> MYXk[YNz\WG|ZTDpckBieG:ydH;0bYMh[2WubIOgZ49ueGG{ZXSgeI8hXC1{IITvfIlv NVTS[XBzOjVyOES3OVU>
RPMI 8226 NITRd2NCeG:ydH;zbZMhSXO|YYm= MXexNFDPxE1? NVjRSI1JOWh? MYPhcI1we3RiY3;tdIxmfGWueTDicI9kc3NiY3XscEBl\WG2aDDjZZV{\WRiYomgcoVkem:|dHH0bY4uOQ>? M161NlI2ODN5OEWx
U266  M4rGNWFxd3C2b4Ppd{BCe3OjeR?= MkjVNVAx|ryP M{\5dFFp MkXTdIFzfGmjbHz5JIJtd2OtczDj[YxtKGSnYYToJINifXOnZDDifUBv\WO{b4P0ZZRqdi1z Ml;JNlUxOzd6NUG=
H929  M{XHfGFxd3C2b4Ppd{BCe3OjeR?= MWixNFDPxE1? NXqwZWdHOWh? NHTKUGtx[XK2aXHscJkh[myxY3vzJINmdGxiZHXheIgh[2G3c3XkJIJ6KG6nY4Lvd5RifGmwLUG= NYG5RYxJOjVyM{e4OVE>
MM.1S  NFnFeG9CeG:ydH;zbZMhSXO|YYm= NGq3eoQyODEQvF2= M4nlXVFp NFz5RVBm\m[rY3nlcpRtgSCycnX2[Y51eyC|b4Lh[oVvcWJvaX7keYNm\CClZXzsJIRm[XSqIHPvcYJqdmVid3n0bEBv\WO{b4P0ZZRqdi1z MkXYNlUxOzd6NUG=
C6 MWPBdI9xfG:|aYOgRZN{[Xl? NGriN4I2OM7:TR?= NXLtfJpkPDiq MkP6dJJmfmWwdIOgeIhmKGyxc4Ogc4Yh[2WubDD2bYFjcWyrdImgZ4F2e2WmIHL5JJBz\WewZX7vcI9v\Q>? M1rtOFI2ODF|NEe5
AGS NYD5fIlOSXCxcITvd4l{KEG|c3H5 NFrtdpU2OM7:TR?= MX:yOIg> NUHJUWdY[WKxbHnzbJMh|rJvbHHwZYNpd26nLXnu[JVk\WRiY3XscEBl\WG2aDDhcoQhcW6qaXLpeIVlKGe{b4f0bC=> NX7OUXY3OjVyMEm2PVg>
HeLa  MUfBdI9xfG:|aYOgRZN{[Xl? MYK0NO69VQ>? NGDwcW4zPGh? M3;KTIlvcGmkaYTzJJRp\SCrbnPy[YF{\WRiYYDvdJRwe2m|IHnu[JVk\WRiYomgd4lTVkZzMkG= NEexe3gzPDl{OE[4OS=>
THP-1  NGfFRVFCeG:ydH;zbZMhSXO|YYm= NFz0NlYyOM7:TR?= NHvFWoQycA>? MYLy[YR2[2W|IHHwc5B1d3OrczDpcoR2[2WmIHL5JGFNSS2VRGVCpC=> NEfjRYEzPDl{M{[1Ny=>
P815  NXzE[FVySXCxcITvd4l{KEG|c3H5 MoXBNVAxKML3TR?= NX7lbIZHOTKq M33aS2ROW09? MYTpcohq[mm2czD2bZJ2ey2rbnT1Z4VlKGGyb4D0c5Nqew>? NWniZ41jOjR7MkOyO|M>
HCT116 NWXvU|RQSXCxcITvd4l{KEG|c3H5 NYfTU3poOjEQvF2= MkXDNlRp MXXhZpJw\2G2ZYOgc4YhXFFvaX7keYNm\CCjcH;weI9{cQ>? NFzYenczPDh7MES0PS=>
SW1116  MYTBdI9xfG:|aYOgRZN{[Xl? MVGxNEDDvU1? MVKxbC=> NULXd2hbTE2VTx?= MWPy[ZN1emGrboOgZ4VtdCCjcH;weI9{cXNiaX7keYNm\CCkeTDn[YZqfGmwaXKgdIx2eyCmZXPpeIFjcW6n M375SVI1QDd2Mki2
LOVO NV7FcHZJSXCxcITvd4l{KEG|c3H5 MmnxNVAhyrWP NWTaUolKOWh? NVL4OpNwTE2VTx?= M4XMWJJme3S{YXnud{Bk\WyuIHHwc5B1d3OrczDpcoR2[2WmIHL5JIdm\mm2aX7pZkBxdHW|IHTlZ4l1[WKrbnW= M16yOlI1QDd2Mki2
SNU449  M1W5R2Fxd3C2b4Ppd{BCe3OjeR?= NITZcI0zOM7:TR?= MWG0PIg> MmnuSG1UVw>? MWfk[YNz\WG|ZYOgcYlTNTR3MT3pcoR2[2WmIHHwc5B1d3SrYx?= MoiyNlQ5PDF4M{i=
Caco-2 NUPXUIlKSXCxcITvd4l{KEG|c3H5 M1ThSVQx6oDLzszN NWjSdpU4PGh? NX\vXZdseHKndnXueJMhW1RvNz3pcoR2[2WmIGrPMVEh[2ijbnfld{BidmRiVFXSJIRzd3B? NETVSpczPDh{MkG4Ny=>
macrophage MnLER4VtdCCYaXHibYxqfHliQYPzZZk> NYPOenhWOC1{MEFOwG0> NFzTUJgzPGh? MnjSbY5lfWOnczDUUmYuKGGwZDDSbZA{NWSncHXu[IVvfCCwZXPyc5B1d3OrczDpckBu[WO{b4DoZYdm NV3CVmNOOjR5OUm1OlU>
AGS  NEi2OWVCeG:ydH;zbZMhSXO|YYm= MWKyNO69VQ>? MW[xNog> MVvEUXNQ NFTTO|hz\WS3Y3XzJJRp\SCrbnT1Z5Rqd25ib3[gZZBweHSxc3nzJIlvKHKnc4DvcpNmKHSxIITo[UBGfE:DYzDmdoFkfGmxbjDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= M{Hr[VI1Pzh7N{Cz
LCC9  MonGR4VtdCCYaXHibYxqfHliQYPzZZk> NFX3PZEyODEQvF2= NHfkT|E2\A>? NIPLR|JjdG:la4OgZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KGOxbXLpcoF1cW:wIFyxO{BidmRiY3jsc5JweXWrbnW= NW[ye2V5OjR5OEWyOVY>
U937  NGLXWJhv\WO{b4D0c5NqeyCDc4PhfS=> NHfRcoUyOMLizszN M3:xPVMxyqCvaX6= NGnnfmJqdmS3Y3XzJI5m[3KxcITvd4l{KGOxbXLpcoUhf2m2aDDUUmY> NVr1TXpKOjR5N{O3OVY>
T cell M4LGPGNmdGxicILvcIln\XKjdHnvckBie3OjeR?= NITse|QxNTFyMN88US=> NV3VfWhxPzKq M1:xXmlEPTB;N{Cg{txONCCrbnjpZol1eyCjboTpMWNFOy2rbnT1Z4VlKFRiY3XscEBxem:uaX\ldoF1cW:wIHnuJHBDVUO| NHLkcYYzPDd4OEewOy=>
HeLa  MmD2RZBweHSxc3nzJGF{e2G7 MWq1NO69VQ>? NIOx[Go4Omh? MkjxSG1UVw>? NY\WSndjeHKndnXueJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3;tdI92dmS|wrCx5qCUPQ>? MWKyOFc2PDd6Nh?=
HeLa  NH\UUHNCeG:ydH;zbZMhSXO|YYm= NIDwNJAyODEQvF2= NEnwUlUzPGh? M4\tZpN2eHC{ZYPz[ZMhemG2ZTDv[kBk\WyuIHTlZZRpKGmwZIXj[YQh[nlib4\ldoV5eHKnc4Ppc44hd2ZiR{W5V{BweiCJN{HSJJAyPTCpbIXl[OKh MUKyOFczOjR4OB?=
IEC-6  NXjrT446SXCxcITvd4l{KEG|c3H5 NGjLNmcyOM7:TR?= MYiyOIg> M{SySpBz\X[nboTzJHRk\EFvaX7keYNm\CClYYPwZZNmNTNiY3zlZZZi\2ViYX7kJO6zNWOjdHXubY4h\GWpcnHkZZRqd25? NGD0ZmUzPDdzMUW3NS=>
HCT116 NUnzSVVLSXCxcITvd4l{KEG|c3H5 NGHmZ5AzOM7:TR?= NWjqR29rOjSq MY\pcohq[mm2czD0bIUh[2WubDDhdI9xfG:2aXOgbY5lfWOnZDDifUB[VFR{MEW= M4CxOVI1PzF|OEGy
L02 MWnBdI9xfG:|aYOgRZN{[Xl? MVyyNO69VQ>? M3PuW|Fp NGjD[41xemW4ZX70d{B1cGViY3XscEBieG:ydH;zbZMhcW6mdXPl[EBjgSCPRVjQ NF7NZnAzPDdyNkS2NS=>
A375 M33tbmFxd3C2b4Ppd{BCe3OjeR?= Mlv6NlDPxE1? M2DISlI1cA>? NETDeWFz\X[ncoPld{BlcWOrdILpco9v\SCELXnu[JVk\WRiYYDvdJRwe2m| NE[zNlgzPDZ7OUGxNS=>
HDPC MmnpRZBweHSxc3nzJGF{e2G7 M4Tp[VUxyrWP M{fkVlI1cA>? NV7GSXRXcW6qaXLpeJMhVk9vaX7keYNm\CCjcH;weI9{cXN? MWOyOFY{PDV7Mx?=
A549 MVLBdI9xfG:|aYOgRZN{[Xl? MYe1NOK2VQ>? M1S5bVJp NX;4UHk1TE2VTx?= NH;WS4ZxemW4ZX70d{B1cGViaInwc4RqeGyxaXSgSG5CKGOxboTlcpQheGijc3WgbY5lfWOnZDDifUBk\XCqYXzvZ4hzd22rbh?= NVXxb2Y3OjR3OEixN|U>
 BV-2 NEH5UpJCeG:ydH;zbZMhSXO|YYm= MYSyNO69VQ>? M2rUR|Jp NELaVmh{fXCycnXzd4V{KFWYLXnu[JVk\WRiY3jyc41ifGmwIHX4eJJ2e2mxbjDhcoQh\GmuYYTpc44hd2ZidHjlJI52[2ynYYKg[Y53\WyxcHW= NFK3TlkzPDV3OEGxPC=>
HT-29  NIi4TFJCeG:ydH;zbZMhSXO|YYm= NIXRZ3M2OM7:TR?= NVjzdnJ4PDiq NG[2eIhjdG:la4OgeIhmKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IHvh[Y1x\mW{b3y= MV6yOFU1QTF5NR?=
A549 NYjXRVZVSXCxcITvd4l{KEG|c3H5 NWXrRo05Pc7:TR?= M2LvNlI1cA>? NVL1bXFye3WycILld5NmeyB4ZdMgLGJMOTByNECpMYlv\HWlZXSgZZBweHSxc3nzxsA> MkDPNlQ2Ojl6N{G=
MIA-PaCa-2 NHHjToFCeG:ydH;zbZMhSXO|YYm= MkLPNlRp NX:2VZhS[myxY3vzJINt\WG4YXflJI9nKGOjc4Dhd4UuOyCrbnT1Z4VlKGK7IHLveIghSS12NEO2OVQh[W6mIIDhZ4xqfGG6ZXy= M1zHbVI1PTFyOUmy
Caki-1 M2PXdGFxd3C2b4Ppd{BCe3OjeR?= MViyNO69VQ>? MYqxbC=> MkOxbY5pcWKrdIOgV2NRNWmwZIXj[YQh[XCxcITvd4l{ MoHNNlQ2ODR4OEG=
CLL NYXJcHFMSXCxcITvd4l{KEG|c3H5 NVTIOoZoOjYQvF2= M3XmbVFp NIO5O5Jx[XK2aXHscJkh[myxY3vzJG1NVjJ{M{itbY5lfWOnZDDj[YxtKGGyb4D0c5Nqew>? MkiyNlQ1Pjd4M{S=
SGC-7901 NHj5Vo1CeG:ydH;zbZMhSXO|YYm= NX3pVGd1OTEQvF2= NHLJXpozPGh? M2PETZBzd22xdHXzJJRp\SCFR1nJMYlvcGmkaYTl[EBk\WyuIHfyc5d1cCCrbjDTS2MuPzlyMTDj[Yxtew>? NFTDOlQzPDR3NES4PC=>
k1735 Mnz2RZBweHSxc3nzJGF{e2G7 MXGyNQKBkc7:bR?= MVi0bC=> NXO0VIxucW6qaXLpeJPDqFOjbH3vcoVtdGFvaX7keYNm\CCjcH;weI9{cXN? M3\ZfVI1PDVzMUG2
HaCaT  NWPaZ2ZjSXCxcITvd4l{KEG|c3H5 MkT4NVAx|ryP Mmf3NYg> NU\C[odL[my3boTzJHVXSi2rbnT1Z4VlKGGyb4D0c5NqeyCrbjDIZWNiXCClZXzsdy=> NFLq[VUzPDN3Nkm5Oy=>
podocytes MlnkRZBweHSxc3nzJGF{e2G7 M3fHXFIxOM7:TR?= NFLidWc3cA>? MVHpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUA{NDRvRFfF MXqyOFM{Pzd5Nx?=
 KB NV;2coJxSXCxcITvd4l{KEG|c3H5 MorpOVDPxE1? NHzOdVYzPGh? NUH6Wo9pcW6qaXLpeJMhVGmlbz3BMYlv\HWlZXSgZ4F{eGG|ZT2zJIFv\CCSQWLQJIFkfGm4YYTpc44> MmTaNlQ{Ozd2OUK=
 HepG2  NIexdZhCeG:ydH;zbZMhSXO|YYm= NIXROIkyOM7:TR?= NVrpcpBxOjSq MWfy[YR2[2W|II\pcYVvfGmwIHPs[YF3[WenIHPheZNm\CCkeTDMVHM> MlHUNlQ{OjV6MU[=
fetal rat lung fibroblasts  MnLaT4lv[XOnIFHzd4F6 MXG4NO69VcLi M{T2R|Fp MVrpcohq[mm2czDDZZNx[XOnLUOgZYN1cX[rdIpCpC=> NXLDdJNiOjR|MUSxN|U>
PDL fibroblasts NHLUSFZMcW6jc3WgRZN{[Xl? MUS4NO69VcLi NXu2NFNzOWh? MUXpcohq[mm2czDDZZNx[XOnLUOgZYN1cX[rdIpCpC=> NVW2eo1zOjR|MUSxN|U>
MB49 NYTy[mt2SXCxcITvd4l{KEG|c3H5 MmfzNlDPxE1? M3LRcFFp M4\BNpJmfmW{c3XzJGNONWmwZIXj[YQh[2WubDDk[YF1cA>? NFLSTI8zPDJ6MkSzNy=>
5637 NFfkcVdCeG:ydH;zbZMhSXO|YYm= NVPhW2t4OjEQvF2= NFnE[YUycA>? M17BNJJmfmW{c3XzJGNONWmwZIXj[YQh[2WubDDk[YF1cA>? MVuyOFI5OjR|Mx?=
A549  NEjzT5ZCeG:ydH;zbZMhSXO|YYm= M1iyPFExOM7:TR?= MUe0PIg> MlrOd5VxeHKnc4Pld{B1cGViYYDvdJRwe2m|IHPheZNm\CCkeTDwbZBmemmwZdMg MYOyOFI4OjJyMR?=
MCC-2 NInZOZJCeG:ydH;zbZMhSXO|YYm= MVyyNEDPxE1? M4Lj[|Zp NGPRN4tFVVOR MkntZoxw[2u|IHnu[JVk\WRiYomgd5RifXKxc4Dvdolv\SCjcH;weI9{cXNiY3XscEBl\WG2aB?= NXvsZlRlOjR{NkK2OVg>
ADF NUPuPXBGSXCxcITvd4l{KEG|c3H5 MUO0NO69VQ>? MmfYOog> MoHYbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2inbX;0bIVz[XC7IIDseZMhYm6FbEK= NITHVVkzPDJ{OEKzNi=>
 U373  M17lVWFxd3C2b4Ppd{BCe3OjeR?= NInJVFA1OM7:TR?= M1zyXFZp MX\pcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkcGWvb4To[ZJieHlicHz1d{BbdkOuMh?= NWfMfW5qOjR{MkiyN|I>
RKO-HIPK2i NH7adVNCeG:ydH;zbZMhSXO|YYm= NF\PNVE1OM7:TR?= M4fwWlZp NWDxOWlocW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3jlcY91cGW{YYD5JJBtfXNiWn7DcFI> MXqyOFIzQDJ|Mh?=
HEC-1B NEOzd|JCeG:ydH;zbZMhSXO|YYm= NIr1fVYzOM7:TR?= NYi5Rm9oOWh? MnrQdoVlfWOnczDUVE1qdmS3Y3XkJIFxd3C2b4Ppd:Kh[2G|cHHz[U0{KGGwZDDjZZNx[XOnLUm= NGHxcIgzPDJzM{O1PC=>
4T1 MYHD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NVrCXpM{Oi53LUGw{txO NX3BTG1QPGh? MVPEUXNQ NFTqW4Vz\XOldXXzJJRp\SCleYTveI95cWOrdImgc4YhPFRzIHPlcIx{KGmwZIXj[YQh[nliU2DEWEBqdiCjIHPvcoNmdnS{YYTpc44h\GWyZX7k[Y51KG2jbn7ldi=> M3fwVVI1OjB4MU[x
OS  NIHsfXJCeG:ydH;zbZMhSXO|YYm= NYjmPG1mOjEQvF2= NXfkNGNJPGh? M33GRYlvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHPheZNm\CCkeTDQSHQ> NFTYU3QzPDJyNEmzOy=>
RPE MkPJRZBweHSxc3nzJGF{e2G7 NW\2dZdxOTByzszN NG[xOG01QGh? MYHwZZJ1cWGubImgbY5pcWKrdIOgeIhmKGOjbIDhbY4uOSCjbnSgMVIh[WO2aY\heIlwdiCjczD3[YxtKGG|IITo[UBk[XOyYYPlJIFkfGm4YYTpc44> M1fHZlI1OjB{MEWy
UD29a NWPlR4xkSXCxcITvd4l{KEG|c3H5 Ml;MOVDPxE1? Mkm5NlRp NFPzU4FqdmirYnn0d{B1cGViY3XscEBl\WG2aDDjZZV{\WRiYomgUnVVOw>? M{jXd|I1OTlyNUe0
SH-SY5Y  M3XMfmFxd3C2b4Ppd{BCe3OjeR?= NYLhbHRUOTEQvF2= MYWyOIg> NXXGUIYy[XS2ZX71ZZRmeyClYYPwZZNmKGGldHn2ZZRqd25iYX7kJINmdGxiZHXheIghcW6mdXPl[EBjgSCKTlWtNmRI M1LYUVI1OTR3NE[z
HeLa  M4LTNWFxd3C2b4Ppd{BCe3OjeR?= Ml;kNVAwOjEQvF2= MonhNlRp MmjubY5pcWKrdIOgeIhmKGGldHn2bZR6KG:oIITo[UBu[Wqxcnn0fUBw\iC2aHWgcYVu[mW{czDv[kB1cGViY3HzdIF{\S2oYX3pcJk> NGnhWJUzPDF|N{K2Oi=>
SCCVII  MYfBdI9xfG:|aYOgRZN{[Xl? NUfSRllXOjYQvF2= Mk\DNYg> Mk\zbY5pcWKrdIOgeIhmKGOnbHygb4ltdGmwZzDh[pRmeiCmYYPheIlvcWJ? M3vVUlI1OTJ4NE[0
RAW 264.7 NWPRSo5mSXCxcITvd4l{KEG|c3H5 NVm0cVN[OjEQvF2= M4TZT|E5cA>? MmXzbY5kemWjc3XzJGxEOy2LST1Otk1i[3SrbjDyZZRqdyClb33wZZJm\CC2bzDFR3RXNU2RUzD0doVifG2nboSgc45tgQ>? MXqyOFEyPjdyNx?=
A549  NVnVT3RuSXCxcITvd4l{KEG|c3H5 M1LTUlIvPc7:TR?= NXHLNnBzOjSq MX\k[YNz\WG|ZYOgc5Jq\G:waX6tbY5lfWOnZDDheZRweGijZ4mgZZMhf2WubDDhcoQhVG:|czDv[kDPnM,KbTDhcJNwKG:lY4XydoVlKGS3cnnu[{BifXSxcHjh[4lkKHC{b3Pld5M> Mlv1NlQyODJ3MkK=
UM-SCC-10A  MVTBdI9xfG:|aYOgRZN{[Xl? MmXROVDDvU1? NWTp[WloOmh? Mn7idoVlfWOnczDhdI9xfG:|aYOgbY5lfWOnZDDifUBpcWeqLXTvd4UhcXOxYXzhcpRwdGGldH;u[S=> MY[yOFA6QDd3Mx?=
BGC-823 MlvVRZBweHSxc3nzJGF{e2G7 NEXXVWMyOCEQvF2= NFH5e|QzPGh? MlvRdoVlfWOnczD0[ZRz[W6mcnnu[U1qdmS3Y3XkJIFxd3C2b4Ppd:Kh M4fHRVI1ODl6NUGx
Nalm-6  MVvBdI9xfG:|aYOgRZN{[Xl? MkPhNlDPxE1? M2TE[lRp NYXpc3hscW6qaXLpeJMh[2G|cHHz[U05KGGwZDDjZZNx[XOnLUOgZYN1cX[jdHnvckBidmRiUFHSVE0yKGOuZXH2ZYdm MUOyOFA{QTl4Nx?=
KHOS  NV;XOlg3SXCxcITvd4l{KEG|c3H5 M4rHVVQx|ryP MViyOIg> MmTJZoxw[2u|IITo[UBqdmO{ZXHz[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHnu[JVk\WRiYomgRmJOTDQEoB?= MV[yOFAzPTN4MR?=
G292 MlG3RZBweHSxc3nzJGF{e2G7 M2DxZlQx|ryP MmrsNlRp NYnFNJNj[myxY3vzJJRp\SCrbnPy[YF{\WRiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIFv\CCSQWLQJIlv\HWlZXSgZpkhSkKPRERCpC=> NVT3fGk6OjRyMkWzOlE>
MG-63 MX7BdI9xfG:|aYOgRZN{[Xl? M1LHc|Qx|ryP NVuyPIhsOjSq MofWZoxw[2u|IITo[UBqdmO{ZXHz[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHnu[JVk\WRiYomgRmJOTDQEoB?= M1r2NVI1ODJ3M{[x
EBV-transformed B cells NY\5OmRpSXCxcITvd4l{KEG|c3H5 Mly4NlDPxE1? MmPzNog> M{T6SGROW09? Ml7oZoxw[2u|IHHueIkuS0R6MDDhcoQh[W62aT3DSFg3KGGwdHnic4R6NWmwZIXj[YQh[XCxcITvd4l{ M4HLT|I1ODB6NkK4
IM-9 B NVjLTpVnSXCxcITvd4l{KEG|c3H5 NWDjeZBWOjEQvF2= MX6ybC=> NXzzWnFPTE2VTx?= NHnsWJFjdG:la4OgZY51cS2FREiwJIFv\CCjboTpMWNFQDZiYX70bYJw\HlvaX7keYNm\CCjcH;weI9{cXN? MXSyOFAxQDZ{OB?=
CNE1 NIfKZYpCeG:ydH;zbZMhSXO|YYm= NG\IZYEzOM7:TR?= MXi0PIg> M1HOfIJtd2OtczDMT{1CNWmwZIXj[YQh[XCxcITvd4l{ MYKyN|k5PTB{OR?=
CNE2 M3ziVmFxd3C2b4Ppd{BCe3OjeR?= NWfOXotjOjEQvF2= NUHDS2FpPDiq MmT4Zoxw[2u|IFzLMWEucW6mdXPl[EBieG:ydH;zbZM> M3X1e|I{QTh3MEK5
HL-60 M3G4[GFxd3C2b4Ppd{BCe3OjeR?= MXG1NOK2VQ>? MUGxbC=> M3rHUGROW09? MXLpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBDSTF2NR?= M{TleFI{QTR6N{Wx
L929 NEDkSIRCeG:ydH;zbZMhSXO|YYm= MVOxMlI26oDVNdMg{txOyqB? NIjzbFczPGh? NHXyempifWevZX70d{BVVkcQsT3pcoR2[2WmIH7lZ5JweHSxc3nzJIFv\CCjdYTvdIhi\3l? MXmyN|k1OTd4OR?=
Jurkat M1mwNGNmdGxiVnnhZoltcXS7IFHzd4F6 NIPzWo8z|ryP NWixcIdVPGh? NXLRXopXemW4ZYLz[ZMh\3Kxd4ToJIlvcGmkaYTpc44h[W6mIN8yMYNifGWwaX6g[IVkemWjc3WgZpkhUFNvQWPB M1u4T|I{QDl4ME[x
RAW264.7  MkTvRZBweHSxc3nzJGF{e2G7 M1HDWFExKM7:TR?= MU[yOIg> NH75ToJl\WO{ZXHz[ZMhfGinIHHwc5B1d3OrczDpcoR2[2WmIHL5JGdC MYKyN|gzODJyMx?=
A431  MlfhT4lv[XOnIFHzd4F6 NVHHSFZtPDEQvF2= M3zlTlJp NH\ERVFjdG:la4Og[ol{\XSrbj3pcoR2[2WmIHPs[YF3[WenIH;mJINie3Cjc3XzJIFv\CCSQWLQ NGrQfYkzOzhyMEC1PC=>
Jurkat MnHGR4VtdCCYaXHibYxqfHliQYPzZZk> MoGwNlUuOTByzszN MlHpOog> MlPubY5pcWKrdIOgfk1HSS2FTVutbY5lfWOnZDDj[YxtKGSnYYTo NYnTZVkzOjN7M{O1N|I>
COS-7  MkPkSpVv[3Srb36gRZN{[Xl? MUO1NOK2VQ>? NI\Ce5kzPGh? MYHh[oZm[3S|IITo[UBxem:lZYPzbY5oKG:oIFHUUlF{KHerdHigdI9tgVFidILhZ5R{ Ml\kNlM6OzN{MEi=
CAL27 NEfkWXdCeG:ydH;zbZMhSXO|YYm= M4qyfFExKM7:TR?= NXfI[IxqOmh? M1vTdpN2eHC{ZYPz[ZMhS3W{LV7Qd{1z\WS3Y3XkJJZq[WKrbHn0fUBjgSC3cDD0c{A6OCV? MoDPNlM6OTd|OU[=
THP-1  M3;BVmFxd3C2b4Ppd{BCe3OjeR?= NX\jRYl4OTBvNUFOwG0> NYC0V|RpOmh? NWX6O2FwcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nlidILpdJRwdGmmZR?= M1rKclI{QTByMkm5
K562 NGPrfm1CeG:ydH;zbZMhSXO|YYm= NX\BdFBOOjEQvF2= Mn;6OFhp MlTHbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhPC2PVR?= NVjPVGpSOjN6N{[4NlY>
HL-60 M4\JXWFxd3C2b4Ppd{BCe3OjeR?= NV3BUJc5OTByzszN NFrYUVgzPGh? MmnNbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[WKrZYThcoUh\Gm2ZYLw[Y5me8Li NHTiZVkzOzh4NUe3PC=>
HeLa  NXHOOoJNSXCxcITvd4l{KEG|c3H5 MV6yNO69VQ>? Mnr1Nog> M{XxWYlvcGmkaYTzJGROVVBiaX7keYNm\CCjcH;weI9{cXN? NHnpSHMzOzh4M{m2Oi=>
U251 MUfBdI9xfG:|aYOgRZN{[Xl? NUfTVJAxOjEQvF2= MmLQNlRp MYfpcohq[mm2czDjZZN1cWOrbjDpcoR2[2WmIFeyM20heGijc3WgZZJz\XO2IHHu[EBieG:ydH;zbZM> M3zJU|I{QDF4OEG2
HL-60 NWDSd5ZKSXCxcITvd4l{KEG|c3H5 M4PxVFUxyrWP Mlz3OIg> NUjzUHBm[myxY3vzJJRp\SClbHXheoFo\SCxZjDjZZNx[XOnLUOsJE06NCCjbnSgVGFTWCCrbnT1Z4VlKGK7IE\z MVeyN|gxPDdyNh?=
Ec-109 M37LT2Fxd3C2b4Ppd{BCe3OjeR?= MonNNVAh|ryP NFHVNmI1QGh? M4G0PJJmeHKnc4Pld{BRTS2vZXTpZZRm\CCHYz2xNFkh[2WubDDhdI9xfG:|aYO= NVvMOVVzOjN5OEK2OFE>
RKO M3PBTGNmdGxiVnnhZoltcXS7IFHzd4F6 M{PDTFExKM7:TR?= NHXmc|czPGh? M{TXeIlvcGmkaYTzJJRp\SCmZXPy[YF{\SCxZjDj[YxtKH[rYXLpcIl1gSClYYXz[YQh[nliRFHC NXq0O3V4OjN5NUiwOlQ>
T98G NXHGeXdtS2WubDDWbYFjcWyrdImgRZN{[Xl? MUixMVExOM7:TR?= NHKxW|MzPGh? M2\tdIlueHKxdnXzJINmdGxidnnhZoltcXS7IHPveJJm[XSvZX70JJdqfGhiVGO= MoHpNlM4Pjl{N{W=
Jurkat NWewRmRkS2WubDDWbYFjcWyrdImgRZN{[Xl? MX2xNFAuOjByzszN M2\o[lI1cA>? MmjnbY5pcWKrdIOgTIFCPCCrbnT1Z4V{KGGyb4D0c5NqeyCmZYDlcoRmdnRib3[gZ49v[2WwdILheIlwdsLi M4HESVI{PzN{NEix
Molt-3  M1jqfmFxd3C2b4Ppd{BCe3OjeR?= M4rGT|Ux|ryP NWn2S3lmOmh? MVry[YR2[2W|IH3lcIF1d26rbj3pcoR2[2WmIHHwc5B1d3Orcx?= NUDRR2JNOjN5MkWwNVM>
hMSC12 NUHyc|g4SXCxcITvd4l{KEG|c3H5 MkKxNVAx|ryP M4ThfVRl MkPGbY5pcWKrdIOgc5N1\W:pZX7pZ{BkfWy2dYLlMYlv\HWlZXSgZ4VtdCCmZXH0bEBidmRiY3HsZ4lncWOjdHnvci=> NViyZlFbOjN4NUe4NlI>
HM7  MoL4RZBweHSxc3nzJGF{e2G7 M{HQVVIx|ryPwrC= NUDzdWpXOWh? NXzwRpZQ[myxY3vzJIFxcWO3bHHy[Y4hSSCjY3X0ZZRmNWmwZIXj[YQh[2G|cHHz[U0{KGGldHn2ZZRqd25iYX7kJHBCWlBiY3zlZZZi\2V? NYjFNpM4OjN3OEO0NVI>
Hep-2  MV;BdI9xfG:|aYOgRZN{[Xl? NUPaOZhVOjEQvF5CpC=> MVSyOIg> MX3EUXNQ M{nQN4FtdGW4aXH0[ZMhfGinIHTlZ5Jm[XOnIH;mJINmdGxidnnhZoltcXS7IHnu[JVk\WRiYomgd4ltcWKrbnnu MXqyN|U5ODB|Mh?=
HSCs MlfWRZBweHSxc3nzJGF{e2G7 MYW1NO69VQ>? NFr2U|QzPGh? NH\ienRFVVOR MYjpcohq[mm2czDubYxwfGmwaXKtbY5lfWOnZDDEUmEh\GGvYXflJIlv\GmlYYTl[EBjgSCSQWLQJINt\WG4YXfl MY[yN|Q6QTh5NB?=
HL-60  MlP2R5l1d3SxeHnjbZR6KEG|c3H5 NYniflBpOjEQvF5CpC=> NUXrNVVHOjSq NX3sOoNWemWmdXPld{B1cGViY4n0c5RwgGmlIHXm[oVkfCCxZjDFdpk2 MkG5NlM1QTR2OEC=
HA NUH2N3RjSXCxcITvd4l{KEG|c3H5 M37kTlUx|ryP NXzVZllQOjSq MWnzeZBxemW|c3XzJJRp\SClbHXheoFo\SCxZjDQRXJRKGGwZDDjZZNx[XOnLUOsJE04NCCjbnSgMVkhcW6mdXPl[EBjgSCkb4L0[ZpwdWmkL2PBTGE> NUPMWWtYOjN2N{W5OVY>
C666-1 M4\TTmFxd3C2b4Ppd{BCe3OjeR?= M3;wT|Ux|ryP NWXLT3JlOjSq M{K1VpN2eHC{ZYPz[ZMhfGinIHPs[YF3[WenIH;mJHBCWlBiYX7kJINie3Cjc3WtN{whNTduIHHu[EAuQSCrbnT1Z4VlKGK7IHLvdpRmgm:vaXKvV2FJSQ>? MWKyN|Q4PTl3Nh?=
Hepa1-6 MnPjRZBweHSxc3nzJGF{e2G7 MV21NO69VQ>? NXfqcYc5Omh? M37Je4lvcGmkaYTzJIN2emO3bXnuJIFv\CC{ZYP2[ZJifHKxbD3pcoR2[2WmIHHwc5B1d3Orcx?= MV:yN|Q1Pjd3Mx?=
PLC/PRF/5c NV2yN2txSXCxcITvd4l{KEG|c3H5 NIj4XIw2OM7:TR?= NIjCc20ycA>? MXrwdoV3\W62czDhdI9xfG:|aYOgeJJq\2encnXkJIJ6KEOLTh?= MkLrNlM1Ozh6MkS=
HCT116 Ml;IRZBweHSxc3nzJGF{e2G7 MkDzNVAx|ryP NIfXVncyNjWq NELxcoJqdmirYnn0d{BQey2rbnT1Z4VlKGOnbHyg[IVifGh? MYWyN|c1PDN3Mx?=
HCEC MVHGeY5kfGmxbjDBd5NigQ>? NF\FVpo2OM7:TR?= MoPkO|Jp M124ZWROW09? MWry[ZN1d3KnczDv[kB1cGVibn;ycYFtKEiFRVOgdIhmdm:2eYDl NVrlXoI3OjN5NEKwNVE>
Primary rat cerebral cortical neurons NXHzO253SXCxcITvd4l{KEG|c3H5 NEXjT3IyODEQvF2= M2nlelFp M1HOfpBz\X[nboTzJGNlNWmwZIXj[YQh[XCxcITvd4l{KGGwZDDj[YxtKGSnYYTo M4HINVI{PzRzM{G3
MDA-MB-231  M3PVOGFxd3C2b4Ppd{BCe3OjeR?= NGDuWFYzPc7:TR?= MkPhNlRp M3[xRoFjem:pYYTld{BkgXSxdH;4bYNqfHliYX7kJINt\WG4YXflJI9nKGOjc4Dhd4UuOyCjbnSgVGFTWCCrbnT1Z4VlKGK7IGLnNy=> MoXPNlU{Ozd3NES=
NLRP3-Tet-on-MC/9  NIPpcIhCeG:ydH;zbZMhSXO|YYm= MUmxNE01OM7:TR?= NWnVd|dsOTKq NFrU[4VifHSnboXheIV{KHSqZTDj[YxtKGSnYYToJINifXOnZDDifUBESVCVLXHzd49kcWG2ZXSgUmxTWDNibYX0ZY51eyCrbjD0bIUhXGW2LX;uJJN6e3SnbR?= MY[yN|cxOzN6OR?=
KNS42  M{DQU2Fxd3C2b4Ppd{BCe3OjeR?= MlTWOVDPxE1? MonvNYg> MmHTdoVlfWOnczDj[YxtKGSnYYToJIFv\CClb33wcIV1\Wy7IHHic4xqe2inZDDjZZNx[XOnIEOvO{Bi[3Srdnn0fUBqdiC{ZYPwc45{\SC2bzDBRnQuOjZ|L{LES{9u\XSob4LtbY4h[2:vYnnuZZRqd25? Mn[0NlM3QTFzNEW=
MCF-7  MorrRZBweHSxc3nzJGF{e2G7 NHrkdYIzOM7:TdMg NHfUe3g4Omh? NVHtZlZmcW6qaXLpeJMh\XG3b3ytJIFv\CB2LV;IWE1u\WSrYYTl[EBieG:ydH;zbZM> NGO1PIEzOzZ5NU[0Ny=>
hCMEC/D3  MWDBdI9xfG:|aYOgRZN{[Xl? MUiyOe69VQ>? M3qxbFczcA>? M1r4S5Jm\HWlZYOgUJR5SSCrbnT1Z4VlKGGyb4D0c5Nqew>? MX6yN|Y3PTF7OB?=
Jurkat NFS4RXZCeG:ydH;zbZMhSXO|YYm= NX\iOXdROTJwNT21NO69VQ>? MWixbC=> NFq4SXhld3OnIHTldIVv\GWwdHz5JJN2eHC{ZYPz[ZMhW1CKLXnu[JVk\WRiUHHyMVQh[2ynYY\h[4UtKFCDUmCgZ4xm[X[jZ3WsJGRPSSCocnHncYVvfGG2aX;uMEBidmRibH;zd{Bw\iC4aXHibYxqfHl? M{OxS|I{PDR{OUe2
CNE-1 MlPiRZBweHSxc3nzJGF{e2G7 NHjpSWwzOM7:TdMg Mkf2NlRp NYnqOXBncW6qaXLpeJMhWkGGMECxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> Mlu0NlM1OjZ6NUC=
HONE-1 NXXvN24zSXCxcITvd4l{KEG|c3H5 M17xe|Ix|ryPwrC= NFLVVYYzPGh? NWnUbo1tcW6qaXLpeJMhWkGGMECxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> NVric|RKOjN2Mk[4OVA>
astrocytes cell NWjSWWtoSXCxcITvd4l{KEG|c3H5 NEHpUoc1OM7:TR?= MnLSOog> MnGydoVlfWOnczDlZZJtgSCjcH;weI9{cXNiaX7keYNm\CCkeTDzeIF2em:|cH;ybY5m NWDTeJk6OjN2MUG3O|g>
U-937 NV;PRVc4SXCxcITvd4l{KEG|c3H5 MXSxNO69VQ>? M4PkNFMxdWmw M1P2Z5Bz\X[nboTzJHRPTi2rbnT1Z4VlKG6nY4LvdJRwe2m| MXSyN|QyODd2OB?=
MDA-MB-231 M4L5fmFxd3C2b4Ppd{BCe3OjeR?= M1;FN|ExOM7:TR?= MX:xbC=> MXnpcohq[mm2czDz[Y5{cXSrenH0bY9vKHSxIGTSRWlNKHWyb36gUXRFUCCmb4fuMZJm\3WuYYTpc44> M4\ZPVI{PDB6NEK5
HeLa  NXv1UJFnSXCxcITvd4l{KEG|c3H5 MVixNFDPxE1? NUC0bGsxOmh? NHHjbWVjdG:la4OgTnJUNTF3IFnu[JVk\XNiQYDvdJRwfGmlIFPlcIwhTGWjdHi= M1jqNFI{OzR2MES1
Ec109 NIDLeGhCeG:ydH;zbZMhSXO|YYm= MWqxNO69VQ>? Mo[3Oog> M{nITYJtd2OtczDhdI9xfG:2aXOgZ49u[mmwYYTpc44hd2ZiVHH0MXNu[WOQNzDhcoQhemGmaXH0bY9v MWSyN|M{QDV4OB?=
H460  NGLTXFBCeG:ydH;zbZMhSXO|YYm= NIXSdo0yOM7:TR?= NUPQUlBUPmh? MnrWZoxw[2u|IHHwc5B1d3SrYzDjc41jcW6jdHnvckBw\iCWYYStV41i[055IHHu[EBz[WSrYYTpc44> MljoNlM{Ozh3Nki=
HeLa  NYq0OodvSXCxcITvd4l{KEG|c3H5 MY[1NO69VQ>? NEfNb4QyNjWq MULhZpJw\2G2ZYRCpGNpdGGveXTpZU1qdmS3Y3XkJIFxd3C2b4Ppdy=> NFvCblAzOzNyM{iwOC=>
SK-HEP1 NULFSnprSXCxcITvd4l{KEG|c3H5 NUnEc3JyOTByzszN MYqxbC=> M{\NfolvcGmkaYTzJGNzXDFiYXP0bZZifGWmIHPhd5Bie2VvMzygMVctKC16LDCtPUwh[W6mIIDvcJkpSUSSLYLpZo9{\SlicH;sfY1memG|ZR?= MnPtNlM{ODJ4NUC=
QGY7701 NFzye|ZCeG:ydH;zbZMhSXO|YYm= M1\0NlI2|ryP NVezVGtYOS53aB?= NFzm[o5qdmirYnn0d{Bi[2O3bYXsZZRqd25ib3[gd5VjNUdzIIDoZZNmKGmwZIXj[YQh[nliRF;YJEsheXWncnPleIlv MVeyN|I1ODB4MR?=
HepG2 MkP5RZBweHSxc3nzJGF{e2G7 NXXLOYNXOjEQvF2= NXWzWXQxOzCvaX6= MoLWbY5pcWKrdIOgeIhmKGWwaHHuZ4VlKGOnbHyg[IVifGhiYomgZ49u[mmwZXSgeJJm[XSvZX70JI9nKGGyaXflcolvKGGwZDDUVmFKVA>? NF\UO3gzOzJ{NEKzPS=>
U87  NV\EN41rSXCxcITvd4l{KEG|c3H5 Ml\5NlXPxE1? MYSybC=> Mm\1[IVkemWjc3XzJIl{d2yrcYXpdol1cWenbnnuJEhKW0xrLXnu[JVk\WRiYYDvdJRwfGmlIHPlcIwh\GWjdHisJIJ2fCCwb4SgcoVkem:2aXOgZ4VtdCCmZXH0bC=> MVWyN|IzQTZ{Nh?=
HSC-2 MXHBdI9xfG:|aYOgRZN{[Xl? MofONlUwPTEQvF2= MnLsNYg> Mkm3bY5pcWKrdIOgV24uOzhvaX7keYNm\CCleYTveI95cWOrdIm= M2fKdlI{OTV3MkS4
HSC-4 NVnmVGVTSXCxcITvd4l{KEG|c3H5 MXyyOU82OM7:TR?= MWWxbC=> M1PabIlvcGmkaYTzJHNPNTN6LXnu[JVk\WRiY4n0c5RwgGmlaYT5 MWSyN|E2PTJ2OB?=
CL-1 MoTKRZBweHSxc3nzJGF{e2G7 M4fxVVIx|ryP MnvrNYg> NILOc|ljdG:la4OgU3A1PDliaX7keYNm\CClZXzsJIRm[XSq NG[2UWMzOzF|MUe4Ni=>
MEL NX3VSnNFSXCxcITvd4l{KEG|c3H5 NG\CcWYzOM7:TR?= NYTTd3FSOjSq NU\HUpE1TE2VTx?= NXrsdm53cW2yYXny[ZMhWDK[Nz3pcoR2[2WmIF3FUEBk\WyuIHHwc5B1d3Orcx?= MYeyN|AyPDh6Nx?=
Bel-7402  NV;LNJlDS2G|cHHz[UBC[3SrdnH0bY9vKEG|c3H5 M1\6RVUx|ryP MkLxNog> NXrDbmMycW6qaXLpeJMhWEOHLXnu[JVk\WRiYX7vbYtqew>? NGDzXJIzOzByOEe0Ni=>
Eca-109 MVvBdI9xfG:|aYOgRZN{[Xl? NFzLboQzPc7:TR?= NXryWHhWOzCvaX6= MVXpcohq[mm2czDCTk1DOTFvaX7keYNm\CClZXzsJIRm[XSq M1jqbVI{ODd4OU[3
MEL NV\MRYlCSXCxcITvd4l{KEG|c3H5 NXzJfllFOjEQvF2= NUi4[lE3OWh? MkPrSG1UVw>? NFLC[ppqdXCjaYLld{BROlh5LXnu[JVk\WRiTVXMJINmdGxiYYDvdJRwe2m| MorKNlMxOTR6OEe=
Bel-7402  NHjMSphCeG:ydH;zbZMhSXO|YYm= NXHmcI5IPTEQvF2= NGXaUmMzcA>? M4rtdolvcGmkaYTzJHBETS2rbnT1Z4VlKGGwb3nrbZM> M{TGXVI{ODB6N{Sy
L929 NH7SflFHfW6ldHnvckBCe3OjeR?= MoPDNk42|ryP NGfrTWYycA>? M1nRXolv[3KnYYPld{BTUVBzIHX4dJJme3Orb36gZY5lKGW6YXPldoJifGWmIGTOSu6yNWmwZIXj[YQhdWm2b3Poc45lemmjbDDkfZNnfW6ldHnvckBidmRiUl;TJJBzd2S3Y4Tpc44> NIDMO5AzOzByMEWxPC=>
RCC  NWLLeGNQS2WubDDWbYFjcWyrdImgRZN{[Xl? MnTONVAx|ryP M{nJelI1cA>? MV3y[YNwfmW{ZYOgeIhmKH[rYXLpcIl1gSCxZjDj[YxteyCneIDvd4VlKHSxIEG1[E1RT0p{ M2ToNlIzQTlzNEm0
NB2a/d1 NEnJNG5CeG:ydH;zbZMhSXO|YYm= MYOxNFDPxE1? NYftdHZmPzKq NFvGbJVifHSnboXheIV{KHO2YYXyc5Nxd3KrbnWtbY5lfWOnZDDjZZNx[XOnIHHjeIl3cXS7LDDQRXJRNCCjbnSgeIF2KGOuZXH2ZYdm NIDaXoozOjl6OEW0NS=>
T cell NFTqOlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmG2NlUuOTByzszN MnTYNlRp NGjOfWhld3OnLXTldIVv\GWwdHz5JIlvcGmkaYTl[EBVKGOnbHygdJJwdGmoZYLheIlwdiCvZXTpZZRm\CC2aILveYdpKHSqZTDjc{1{fGmvdXzheIlwdiC5aYToJIFvfGlvQ1SzJIFv\CCjboTpMWNFOjh? M1XuVlIzQTh{NUO4
K562 M4XSZ2Fxd3C2b4Ppd{BCe3OjeR?= NVWw[4syOTByzszN NILYUYYycA>? NYDqT3I{[myxY3vzJGFjdm:kYY\pd4N2dcLiRj3pcoR2[2WmIHHwc5B1d3Orcx?= Mn7UNlI6PzJ|N{K=
Jurkat  MniwRZBweHSxc3nzJGF{e2G7 M1\xNlQx|ryP NUDqSoVKOWh? NVSwOpBV[WKxbHnzbIV{KE[jc1ytbY5lfWOnZDDjZZNx[XOnIHHjeIl3[XSrb36gZY5lKGOnbHyg[IVifGh? MorQNlI6PDJ5M{i=
BGC-823 M4HVOWFxd3C2b4Ppd{BCe3OjeR?= MoDONVAx|ryP NILteo0ycA>? M134UJBienSrYXzsfUBz\XOldXXzJINmdGy|IHHnZYlve3RiZHHtZYdmKG:oIHThbYR7\Wmw MW[yNlkzPjV2NR?=
Hep3B M1;sT2Fxd3C2b4Ppd{BCe3OjeR?= M2nI[VUx|ryP NIHzWpAycA>? MV7icI9kc3NiYYDvdJRwe2m|IHnu[JVk\WRiYomgTGVIS3N? M4TjSVIzQTJ|MUW0
LLC-PK1 NVvWe|RbSXCxcITvd4l{KEG|c3H5 MY[yNO69VQ>? NF\0TWgycA>? NXPFbI1[eHKndnXueJMh[2m|cHzheIlvNWmwZIXj[YQh\GWpcnHkZZRqd25ib3[gRZRoPSxiYnXjcIlvNTFuIHHu[EBCfGdzMjDwdo91\Wmwcx?= MVOyNlg6PjB|Nx?=
A549 M{XrSWFxd3C2b4Ppd{BCe3OjeR?= NFzkW4w2OM7:TR?= NIK2d5MycA>? M2i4WYJtd2OtczD0bIUhSkGLLXnu[JVk\WRiYYDvdJRwe2m|wrC= NELGPFMzOjh6N{KxOS=>
SGC-7901  NV3He3Z2SXCxcITvd4l{KEG|c3H5 NXnV[4dHOTEQvF2= NVK2VXBKOjSq MnjjbY5pcWKrdIOg{tIt|rJvZHnt[ZRpgWyjY4L5cJNpcWuxbnnuMYlv\HWlZXSgZZBweHSxc3nzxsA> NE\sXJIzOjh2OEW5Oy=>
DM6 MlXiRZBweHSxc3nzJGF{e2G7 MkDMNVAx|ryP M4LWd|czcA>? MmDaZoxw[2u|IHLveIghTTKILUGgZY5lKEV{RoTyMY1m\GmjdHXkJIN6fG:2b4jpZ4l1gQ>? NUj3fY54OjJ6MkWzNlg>
MCF-7, MDA-MB-468, Caco-2 NV61RWpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[2OVDPxE1? MVu0PIg> MnrPbY5pcWKrdIOgeIhmKGOnbHyg[5Jwf3SqIHnubIljcXSrb36gbY5lfWOnZDDifUB{[XCxbnnu MWKyNlgxODl4OB?=
A2750  MY\BdI9xfG:|aYOgRZN{[Xl? Mn\kNlDPxE1? MoK4Nog> NE\MTXRFVVOR Moi2Zoxw[2u|IHPhd5Bie2ViY3zlZZZi\2ViZIXybY5oKGinbHXuZYxqdiC2cnXheI1mdnRiYX7kJJJm\HWlZYOgZZV1d3CqYXfpZ{Bk\WyuIHTlZZRp Mnz5NlI4QDR|NkO=
U87  NWD1cFc1SXCxcITvd4l{KEG|c3H5 NHzLdXMzOM7:TR?= MYKyOIg> MYny[YR2[2W|IITo[UBieG:ydH;zbZMhemG2ZTDpcoR2[2WmIHL5JHBNSUJ? NHz2fJUzOjd5OEe4NC=>
HT1080 MljRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fpRVUx|ryP NE\yRXk4\A>? MlrsbY5pcWKrdIOgeIhmKGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZ4F2e2WmIHL5JINwdWKrbnXkJJRz\WG2bXXueEBw\iCGQ1GgZY5lKE:PUB?= M4Xk[VIzPzRyOUi0
A549  M1TGN2Fxd3C2b4Ppd{BCe3OjeR?= M2nOSFUx|ryP M3fHb|Jp NGrINIZx[XK2aXHscJkh\GWlcnXhd4V{KHOxZHn1cUB{\Wynbnn0[U1qdmS3Y3XkJIFxd3C2b4Ppdy=> NF7qPY8zOjd{MUiwOC=>
Primary OPC NVTkUI1KSXCxcITvd4l{KEG|c3H5 NH;0Nocy|ryP NVPYbYlVPmhxMkTo NVPSZnRWemWmdXPld{B1cGVicHXyZ4VvfGGpZTDv[kBk\WyuczDpckBm[XKueT2gZY5lKGyjdHWtZZBweHSxc3nzM45m[3Kxc3nz NHTqVFEzOjdyN{O4OS=>
PMNs M{ezcGFxd3C2b4Ppd{BCe3OjeR?= NIPhNGI1OM7:TR?= NWnPTYV2Pmh? NHnOUpNFVVOR MUny[ZZmenOnZDD0bIUh[W2xdX70JI9nKGOuZXH2[YQh[2G|cHHz[U0{KHSxIH7lZZIhfmWqaXPs[UBt\X[nbIO= M2PCSFIzPjl{NUe3
A549  M174bWFxd3C2b4Ppd{BCe3OjeR?= Ml31OVDPxE1? NXzXO|FZOWh? MYHwdoV3\W62czDhdI9xfG:|aYOgbY5lfWOnZDDifUBD[W:qdX;zbYRmKEl? NWPlemM1OjJ4OEe2N|U>
AGS NXrxTXVWSXCxcITvd4l{KEG|c3H5 M4TOeVIx|ryP M4XYSFEzcA>? NHTmTXdqdmirYnn0d{B1cGViYXP0bZZifGmxbjDv[kBxem9vY3HzdIF{\S1|IHnuJJJme3CxboPlJJRwKHSqZTDFeG9C[yCocnHjeIlwdg>? NVTke3VvOjJ4OEezPVg>
shC9  NUKzbFhwSXCxcITvd4l{KEG|c3H5 MXmxNO69VQ>? Ml;0NVZp MYDicJVvfHNiU1jIJIV5eHKnc4Ppc44hcW5ic3jDPUBk\WyuczDlfJBwe2WmIITvJIVqfGincjDQRUBweiCOUFO= M2XDTVIzPjRzMEm0
primary MEFs NFnFUphHfW6ldHnvckBCe3OjeR?= MYKxNog> M{nONOKhcW6lcnXhd4V{KGW2b4Dvd4ll\S2rbnT1Z4VlKG2rdH;jbI9v\HKrYXygcYVu[nKjbnWg[IVxd2yjcnn6ZZRqd25? MXWyNlYyOzd4Nx?=
3T9 MEFs MVPGeY5kfGmxbjDBd5NigQ>? M1fY[|E3cA>? M33mXIlv[3KnYYPld{BkgXSxY3jyc41mKGNicnXs[YF{\SCjZoTldkBmfG:yb4Pp[IUufHKnYYTt[Y51 MUmyNlYyOzd4Nx?=
3T9 MEFs NH;HSVZHfW6ldHnvckBCe3OjeR?= MlznNVhp MVP1dJJm\3WuYYTld{Bqdmm2aXH0c5Ih[2G|cHHz[U06KGK3dDDkc5dvemWpdXzheIV{KGWoZnXjeI9zKGOjc4Dhd4V{KGGodHXyJIV1d3Cxc3nk[UB1emWjdH3lcpQ> MY[yNlYyOzd4Nx?=
MDA-MB-231  MkfURZBweHSxc3nzJGF{e2G7 M{nEeFIx|ryP M1KwPFRl NV;jV2UzemWmdXPld{B1cGViY3XscEBieG:ydH;zbZMhcW6mdXPl[EBjgSCvZYTmc5JucW5idILlZZRu\W62IIfhd{B{cWewaX\pZ4FvfGy7 NV3kflFZOjJ3OUO0OFE>
C6  MlPuRZBweHSxc3nzJGF{e2G7 M4n5bFEx|ryP MUGyOIg> M1PBPYJtd2OtczD0bIUhe3WycILld5NqfmViZX\m[YN1KG:oIITo[UBx\XC2aXTlJI9vKH[rYXLpcIl1gQ>? MlTWNlI2QDh7OEC=
HL-60  NF;QfYxCeG:ydH;zbZMhSXO|YYm= M1jBW|ExOM7:TR?= M3e1OlI1cA>? NWT2[ZRocW6qaXLpeJMhfGinIHPlcIwh[XCxcITvd4l{KHOnbHXjeIVlKChtKT3t[Y51cHmuIN8yMUgy6obUNjmt[IlodHWlb4D5doFvd3OrZHZCpFU> NGnme4wzOjV2Nk[2PS=>
HL-60 NHK2PINCeG:ydH;zbZMhSXO|YYm= Mle4NVAuQDEQvF2= NFK1e3k1cA>? Mn\jbY5pcWKrdIOgWGdJWS2rbnT1Z4VlKGOnbHygZZBweHSxc3nzxsA> MVeyNlUzOzJ{OR?=
BCC MVHBdI9xfG:|aYOgRZN{[Xl? MYi1NO69VQ>? MkXSNYg> M{Pa[olvcGmkaYTzJGRCXFNvbXXkbYF1\WRiZ4Lve5RpKGmwaHnibZRqd25? M1vINlIzPTF7NEO2
RAW 264.7 MkKxRZBweHSxc3nzJGF{e2G7 NHiz[mM2OC9zMEFOwG0> M2Dtc|Fp NYTvbY5P[2:wY3XueJJifGmxbj3k[ZBmdmSnboSgbY5pcWKrdIOgSG9PNWmwZIXj[YQhelKQQTDjcIVifmGpZR?= NX;IWmJvOjJ2OUG0NlY>
K562 MkDpRZBweHSxc3nzJGF{e2G7 MWmyOe69VQ>? MUWybC=> NUPxcY5beHKndnXueJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3:teJJm[XSvZX70JJdqfGhiYX31doVve2mwIFegZY5lKFSUQVnM NXLRNo5ROjJ2OEO3O|c>
SGC-7901 MlzURZBweHSxc3nzJGF{e2G7 NEi5c2QzOCEQvF5CpC=> NETjelAzcA>? MVPheJRmdnWjdHXzJGgzVzMEoH;yJHRPTiEQsT3pcoR2[2WmIHPlcIwh[XCxcITvd4l{KGG|IIflcIwh[XNiY3HzdIF{\S1|IHHjeIl3cXS7wrC= NHjJTmwzOjR5MUW4PS=>
PC3 NYXJbIdqSXCxcITvd4l{KEG|c3H5 Mnf2NVDPxE1? MkPpOIg> NYnmblRJ[2:3boTldpMh\myjdn;jc5hq\C2rbnT1Z4VlKGOjc4Dhd4UuemWuYYTl[EBieG:ydH;zbZM> NYnLc4ZYOjJ2N{G5O|Q>
SMMC-7721 MmfYRZBweHSxc3nzJGF{e2G7 NFTIN4U2OM7:TR?= MVm0PIg> MljyZZR1\W63YYTld{BwXFJvaX7keYNm\CCjcH;weI9{cXN? NWfqXlFIOjJ2NkW4N|M>
HeLa  NIjrN5VCeG:ydH;zbZMhSXO|YYm= NHrHUow2OMLizszN NHvSZ4s1Nziq NXjQbYp1cW6qaXLpeJMhW1SVLXnu[JVk\WRibHH0[U1xcGG|ZTDhdI9xfG:2aXOg[ZZmdnS| MXKyNlQ3ODVyNB?=
HeLa  NIHU[VNCeG:ydH;zbZMhSXO|YYm= NHLRcFI2OMLizszN MUGxbC=> M4\SSJN2eHC{ZYPz[ZMhfGinIF\SRXAucW6mdXPl[EBi[2O3bYXsZZRqd25ib3[gZY5v\XirbjDWJJBwe2m2aY\lJINmdGy| NHPkcIczOjR2OUS0NC=>
T47D  NH22NWZCeG:ydH;zbZMhSXO|YYm= NHeySHcyODEQvF2= M4DLWFFp MWricI9kc3NidHjlJIdmdmW{YYTpc44hd2ZiRT3jZYQwS1SIMjDifUBUXFN? MUOyNlQxOTF4OB?=
HeLa  MWLBdI9xfG:|aYOgRZN{[Xl? MXGzNO69VQ>? Mn\TOIg> NHfRU5HDqGmwY4LlZZNmeyC2aHWg[4Vv\XKjbDDj[YxtKH[rYXLpcIl1gSB2ODDoJIFnfGW{IIDoc5Rw\HmwYX3pZ{B1emWjdH3lcpTDqA>? NYnw[I93OjJ|OUSyOFg>
HCC NEHwNW5CeG:ydH;zbZMhSXO|YYm= M3yzTVIxKM7:TdMg MkLWNog> MkDUZZR1\W63YYTld{B1cGViRFjBJIlv\HWlZXSgZYN1cX[jdHnvckBw\iCSQWLQ NYjESVI1OjJ|NEK3N|I>
mESCs NEjzO5JCeG:ydH;zbZMhSXO|YYm= NWHveHBWOi53zszN MkfTNog> MXPpcohq[mm2czD0bIUhVmGILX3l[IlifGWmIHPhd5Bie2ViYXP0bZZifGmxbh?= Mn\mNlIzQDV{N{S=
EMT-6  NXHMSmdVS3m2b4TvfIlkcXS7IFHzd4F6 NYLjSXNzOTByzszN NGnnOHQycA>? NYHCO2xbeGG{dHnhcIx6KGKub3Pr[YQh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IIPpdoFu\XOrbnW= NX\oU5ZOOjJ{NUG5NlE>
MCF7 NHLVT2JCeG:ydH;zbZMhSXO|YYm= NIrBVmg2OMLizszN MlnrNYg> MWLpcohq[mm2czDQRUBi[3SrdnH0[YQh[2G|cHHz[U0{NCBvOTygZY5lKHCxbImoRWRRNXKrYn;z[UkheG:ueX3ldoF{\Q>? MYiyNlIzOzN2NR?=
K562 NUPjb2YzSXCxcITvd4l{KEG|c3H5 MViyNEDPxE4EoB?= NYi5SnczPDiq NX7ibVNsTE2VTx?= M2L4NYJtd2OtczDsZZBifGmwaXKtbY5lfWOnZDDpcohq[mm2aX;uJI9nKH[rYXLpcIl1gSCjbnSgZZBweHSxc3nzJIlv\HWldHnvci=> NUH3d5FROjJ{MU[xOVg>
Molt4-hyg NEXiSXdCeG:ydH;zbZMhSXO|YYm= MorUNVDPxE1? NWnFfHZ4OC53aB?= M{n4bIJtd2OtczDmZZJv\XOxbD3pcoR2[2WmIHPhd5Bie2VvMz3sbYtmKGGldHn2bZR6 MX[yOlI4PThzMR?=
HeLa M4PBUGFxd3C2b4Ppd{BCe3OjeR?= MUSxNO69VQ>? MUewMlVp MYTpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUB1cGViY3;tZolv\WRidILlZZRu\W62IIfpeIgh\2:vaYPpckBPKGGwZDDUVmFKVA>? MkLsNlIyPzl4NkG=
Jurkat T M4LhZ2Fxd3C2b4Ppd{BCe3OjeR?= M2LSVVMx|ryP MV[wMlVp MkDLSG1UVw>? MX7icI9kc3NidHjlJJpqemGvLXnu[JVk\WRiYYDvdJRwe2m| M3TjVlIzOTV7OEm4
Neutrophil NXf6SY1CSXCxcITvd4l{KEG|c3H5 MVqyNO69VQ>? MXywMlVp M3n6Z4F1fGWwdXH0[ZMhfGinIIDyc{1ieG:ydH;0bYMh\W[oZXP0JI9nKE2jUkG= MkLBNlYyQTZ6NES=
HCT116 MmHVRZBweHSxc3nzJGF{e2G7 M2XobVUxyqEQvF2= NHziO4szcA>? NHPoWXlz\X[ncoPld{B{gW6ncnfpd5Rq[yCjcH;weI9{cXNiZX\m[YN1eyCxZjDj[Yxm[2:6aXKgZY5lKE6SQz2xOuKh NW\EeVVjOjJzNUm3OVI>
MDA-MB-231  M3vtO2Fxd3C2b4Ppd{BCe3OjeR?= NGjhTFIzNjVvNz61{txO NF\qRWEzcA>? NGnVZWdqdmirYnn0d{B1cGViY3XscEBl\WG2aDDv[kBOTEFvTVKtNlMyKGOnbHzzJIlv\HWlZXSgZpkhW0SWIHnuJIEh[2:wY3XueJJifGmxbjDk[ZBmdmSnboSgcYFvdmW{ NXfoV2l[OjJzMUW1NlY>
LNCaP MmHXRZBweHSxc3nzJGF{e2G7 NUmzfpVPPDEQvF2= MVKybC=> NGXFRVJqdmirYnn0d{BjfXSnaX6gbY5lfWOnZDDj[YxtKGGyb4D0c5Nqew>? Ml6xNlIyOTR5NkS=
MB231 NXL2cWp5SXCxcITvd4l{KEG|c3H5 NHXMU5YyODEQvF2= M3LNbVFp Mk\CSG1UVw>? NILuUW1i[nKxZ3H0[ZMhfGinIHnu[JVkfGmxbjDv[kBk\WyuIHTlZZRpKGK7IGfFSVEhcW6qaXLpeIlwdixiVGLBTWwhfHKnYYTt[Y51NCCjbnSgeIhmKGOxbXLpcoF1cW:w MkftNlIyOTJ7NEC=
HCC38  M1i4ZmFxd3C2b4Ppd{BCe3OjeR?= M1r0SFExOM7:TR?= NIS3WJQycA>? NVnmOpR6TE2VTx?= NFO2THZi[nKxZ3H0[ZMhfGinIHnu[JVkfGmxbjDv[kBk\WyuIHTlZZRpKGK7IGfFSVEhcW6qaXLpeIlwdixiVGLBTWwhfHKnYYTt[Y51NCCjbnSgeIhmKGOxbXLpcoF1cW:w M1nkSlIzOTF{OUSw
MDA-MB231 MVfBdI9xfG:|aYOgRZN{[Xl? M{\GflUxyqEQvF2= MX[yOIg> M{LrUmROW09? Ml3XZYJzd2ejdHXzJIN2emO3bXnuMYlv\HWlZXSgZ4VtdCCmZXH0bC=> M2nSbVIzOTBzM{O1
LNCaP NGHXOYNCeG:ydH;zbZMhSXO|YYm= MYK1NOKh|ryP M2qxWVI1cA>? MorGSG1UVw>? NEPuXGRi[nKxZ3H0[ZMh[3W{Y4XtbY4ucW6mdXPl[EBk\WyuIHTlZZRp MUSyNlExOTN|NR?=
HCT116 MonGRZBweHSxc3nzJGF{e2G7 M1XsVVUxyqEQvF2= M3nUW|I1cA>? NX33NZJlTE2VTx?= MonQZYJzd2ejdHXzJIN2emO3bXnuMYlv\HWlZXSgZ4VtdCCmZXH0bC=> Mn:wNlIyODF|M{W=
Ishikawa  MVLBdI9xfG:|aYOgRZN{[Xl? MV2yOe69VQ>? MYKyOIg> MlzEdoVlfWOnczDj[YxtKGSnYYToJIFv\CCjcH;weI9{cXNiaX7keYNm\CCkeTDCZYYhSTF? MmPUNlIxQDh7MUi=
 YD-8  NV\2dXl[SXCxcITvd4l{KEG|c3H5 NVjqPWpEOTByzszN Mn3wNYg> MXjpcohq[mm2czDQUGVQNWmwZIXj[YQh[XCxcITvd4l{ MoSyNlIxQDZzOEO=
eosinophil  MW\BdI9xfG:|aYOgRZN{[Xl? M37NNVkx|ryP M3fvc|I1cA>? M2TQSIlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KE[jczDhcpRq[m:medMg MX2yNlA4QTN|NB?=
L929 NWnzVHNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXuyMlXPxE1? NIjOSowzPGh? Mn\IbY5pcWKrdIOgeIhmKGW6cILld5Nqd25ib3[gdE1xOzhiYX7kJG5HNc78QjD0c{BifWevZX70JHRPTs7zLXnu[JVk\WRibnXjdo9xfG:|aYOgZY5lKGG3dH;wbIFogQ>? NX[x[2dSOjJyMkewPVc>
YD-8  Ml7CRZBweHSxc3nzJGF{e2G7 M{fNSVExOM7:TR?= Mo\MNYg> MmXPZoxw[2u|IITo[UBIWy2KQ3ytbY5lfWOnZDDhdI9xfG:|aYO= NXzZeHR1OjJyMkCwO|g>
HBx NX7ycIpLSXCxcITvd4l{KEG|c3H5 NEnEe|YzPc7:TR?= M1zGeVQ5cA>? MYHEUXNQ NY\uOFJQemWmdXPl[EBk\WyuIHTlZZRpKGmwZIXj[YQh[nliMz3NRS=> NFmxNFgzOjB{MEC3PC=>
U937  NI\DfYdCeG:ydH;zbZMhSXO|YYm= NVvxd5VNPTEEoN88US=> MXuxbC=> MUjpcohq[mm2czDISk1qdmS3Y3XkJIFxd3C2b4Ppd:Kh M37wdFIyQTl6N{Ox
HL60 NUSydZRiSXCxcITvd4l{KEG|c3H5 NFvtZWQ1OM7:TR?= MXG0NI1qdg>? Mmj3SG1UVw>? NVzWeo1{[myxY3vzJGJPTENiY3;tdI92dmS|IHnu[JVk\SCneIDvd5Vz\SCxZjDwbI9{eGijdHnkfYx{\XKrbnWgZY5lKESQQTDmdoFodWWwdHH0bY9v NGTtR5AzOTl6M{K5Oi=>
M-14 MXLBdI9xfG:|aYOgRZN{[Xl? NYTCW5pVOjYQvF2= MkDqNE42cA>? NXLo[2pxyqCrbnjpZol1eyCkb4ToJJRp\SClcoXk[UBmgHS{YXP0MUBidmRiY3;tdI92dmRvaX7keYNm\CCjcH;weI9{cXN? M{m0PFIyQTV2OUW5
SK-BR-3 M3;yUmFxd3C2b4Ppd{BCe3OjeR?= NIm2SJk2OMLizszN NXfTfFltOmh? M3PyZoJtd2OtczDhdI9xfG:2aXOgSG5CKG[{YXft[Y51[XSrb36gbY5lfWOnZDDifUBkd22kaX7heIlwdiCxZjDTUU0yPjRiYX7kJJJi\GmjdHnvci=> NXv4OIFqOjF7MEGzPFY>
MDA-MB-468 MUPBdI9xfG:|aYOgRZN{[Xl? NG\SSm42OMLizszN M{HzcVJp M1TXdYJtd2OtczDhdI9xfG:2aXOgSG5CKG[{YXft[Y51[XSrb36gbY5lfWOnZDDifUBkd22kaX7heIlwdiCxZjDTUU0yPjRiYX7kJJJi\GmjdHnvci=> MXeyNVkxOTN6Nh?=

... Click to View More Cell Line Experimental Data

体内研究 有研究表明,体内Z-VAD-FMK的给药不具有毒性,在动物模型中可抑制凋亡。在小鼠中,腹腔注射HK-GBS可引起早产,而预处理以Z-VAD-FMK可延迟早产现象。在OVA-sensitized的小鼠中,z-VAD-fmk的处理可抑制过敏原诱导的白细胞浸润。在OVA致敏前全身性注射z-VAD-fmk可减少OVA-sensitized/challenged小鼠中炎性细胞的积累、黏液的高分泌以及Th2细胞因子的释放。处理以z-VAD-fmk可阻止晶状体上皮细胞、角质细胞的终末分化;单核细胞向巨噬细胞的分化;以及红系造血祖细胞的分化。z-VAD-fmk可减缓过敏原诱导的呼吸道炎症以及高敏性、阻止后续T细胞的激活[7]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[6]

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  • Cell lines: 颗粒细胞GC1a, HGL5, COV434
  • Concentrations: 50 μM
  • Incubation Time: 48 h
  • Method:

    为了确定Z-VAD-FMK的效力,在常氧条件下,用etoposide (50 μg/ml) 和/或 Z-VAD-FMK (50 μM)对三种人源颗粒细胞系(GC1a, HGL5, COV434)进行处理,处理48小时。为了模拟卵巢片段抑制后的缺氧状态,用低氧(1% O2)状态下,用无血清培养基培养细胞,处理以Z-VAD-FMK。用WST-1试验检测细胞的代谢活性。通过FACS检测细胞活力,RT-qPCR和WB检测凋亡相关分子的表达。


    (Only for Reference)
动物实验:

[7]

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  • Animal Models: CD1小鼠
  • Formulation: 溶解于DMSO,用PBS进行稀释,最终DMSO浓度小于1%
  • Dosages: 10 mg/kg
  • Administration: i.p.
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 93 mg/mL (198.93 mM)
Water Insoluble
Ethanol Insoluble warmed
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+35 %PEG 300+2%Tween 80+ddH2O
6mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 467.49
化学式

C22H30FN3O7

CAS号 187389-52-2
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    Can you suggest an in vivo formulation of S7023 for animal studies?

  • 回答:

    For in vivo study of S7023, The IP formulation is 2% DMSO+35 % PEG 300+2% Tween 80+ddH2O up to 6 mg/ml. The gavage formula is 1%CMC-Na up to 30 mg/ml (suspensions).

  • 问题 2:

    What is difference between S7023 & S8102?

  • 回答:

    Unlike S7023, S8102 does not require pretreatment with esterase for in vitro studies. This information was cited from the article: https://www.ncbi.nlm.nih.gov/pubmed/16973565.

Caspase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID