Z-VAD-FMK

For research use only. Not for use in humans.

目录号:S7023

Z-VAD-FMK Chemical Structure

CAS No. 187389-52-2

Z-VAD-FMK是一种细胞渗透性的,不可逆泛caspase抑制剂,在THP.1 和 Jurkat T细胞中阻断细胞凋亡的所有特性。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 6953.84 现货
RMB 962.65 现货
RMB 3841.92 现货
RMB 9746.63 现货

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客户使用Selleck生产的Z-VAD-FMK发表文献622篇:

产品安全说明书

Caspase抑制剂选择性比较

生物活性

产品描述 Z-VAD-FMK是一种细胞渗透性的,不可逆泛caspase抑制剂,在THP.1 和 Jurkat T细胞中阻断细胞凋亡的所有特性。
特性 Z-VAD-FMK是研究细胞凋亡的一种关键化合物。
靶点
Pan-caspase [1]
(THP.1, Jurkat T-cells)
体外研究

Z-VAD-FMK(10 mM)作用于THP.1细胞,抑制细胞凋亡。Z-VAD-FMK(10 μM)作用于THP.1细胞裂解液,抑制PARP蛋白酶活性的激活。Z-VAD-FMK(10 mM)作用于完整THP.1和 Jurkat细胞,抑制CPP32加工。[1]Z-VAD-FMK(50 μM)与Camptothecin共处理HL60细胞,废除Camptothecin处理的细胞凋亡形态。Z-VAD-FMK(50 μM)作用于HL60细胞,抑制Camptothecin诱导的DNA分裂。[2]Z-VAD-FMK (50 μM)作用于S2细胞,提高转染细胞的生存百分数从26%提高到63%。[3]Z-VAD-FMK(>100 μM)作用于人类嗜中性粒细胞,增强TNFα-诱导的中性粒细胞凋亡,较低浓度(1-30 μM)时完全抑制TNFα刺激的细胞凋亡。[4]Z-VAD-FMK (10 mM) 作用于早期角膜基质细胞,抑制细胞凋亡。[5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
U937 MlX0RZBweHSxc3nzJGF{e2G7 MmHVOVDPxE1? MljSOFhp MmXFdoVlfWOnczDj[YxtKGSnYYToJINifXOnZDDifUBUU0lvSVmgeJJm[XSvZX70xsA> NEWxflM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUiyOFA1Oyd-MkW4NlQxPDN:L3G+
HL-60 NGHuUZVCeG:ydH;zbZMhSXO|YYm= MYi1NO69VQ>? M3;2OlQ5cA>? NHf2OG1z\WS3Y3XzJINmdGxiZHXheIgh[2G3c3XkJIJ6KFONST3JTUB1emWjdH3lcpTDqA>? MnuyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MkSwOFMoRjJ3OEK0NFQ{RC:jPh?=
DTK-SME NUnFWVZTSXCxcITvd4l{KEG|c3H5 NYrodFVYPTEQvF2= NXrxO2szOmh? NXi3U5l{TE2VTx?= M1nFdZBienSrYXzsfUBqdmirYnn0d{B1cGViYYDvdJRwe2m|IHnu[JVk\WRiYomgZpVxcX[jY3HpcoU> NX7pUoRzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4OFM5QTdpPkK1PFQ{QDl5PD;hQi=>
HCT116  M3H4UGFxd3C2b4Ppd{BCe3OjeR?= M{fPS|Ux|ryP NInZRXEzcA>? MXPpcohq[mm2czD0bIUh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IFTEWnA> MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh4OEixPEc,OjV6Nki4NVg9N2F-
SGN M3TMcWFxd3C2b4Ppd{BCe3OjeR?= MkjFNlBuVQ>? MYi0PIg> NHzCfnhp[XNibn:gbY5ndHWnbnPlJI9vKEGLRjygZ4FteGGrbjDlfJBz\XO|aX;uJI9zKGOnbHygZZBweHSxc3nz M1nMZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEe0OlM{Lz5{NUi3OFY{OzxxYU6=
A549/V16 MX;BdI9xfG:|aYOgRZN{[Xl? MX:1NO69VQ>? NE\ScHUycA>? NHj0Zmxz\XC{ZYPz[ZMhXEdxVF2tbY5lfWOnZDDhdI9xfG:|aYO= M13aNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUS2NFM{Lz5{NUm0OlA{OzxxYU6=
U1 MVrLbY5ie2ViQYPzZZk> NWLQdWxFOTByzszN NIHOTpQzcA>? NEPiSGpqdmirYnn0d{Bk[XOyYYPlMVM> NWTo[lBsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5PFA6PDJpPkK1PVgxQTR{PD;hQi=>
ACH-2 NEjRUlFCeG:ydH;zbZMhSXO|YYm= NYO3OXZrOC1{MEFOwG0> MnvXNog> M1fNNpJm\HWlZYOg[JJ2\y2rbnT1Z4VlKGGyb4D0c5NqeyCjbnSgd5Vje2WzdXXueEBJUVZvMTDy[ZBtcWOjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> M1XGS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUiwPVQzLz5{NUm4NFk1OjxxYU6=
U1 MkO1RZBweHSxc3nzJGF{e2G7 NVPlS3ZKOC1zMEFOwG0> MoSxNog> M1;qN5Jm\HWlZYOg[JJ2\y2rbnT1Z4VlKGGyb4D0c5NqeyCjbnSgd5Vje2WzdXXueEBJUVZvMTDy[ZBtcWOjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl6MEm0Nkc,OjV7OEC5OFI9N2F-
HUVEC-2c MV;BdI9xfG:|aYOgRZN{[Xl? NYL6NoRxPTEQvF2= M{HlflZp MU\k[YNz\WG|ZXSgeIhmKG:6LVzEUE1qdmS3Y3XkJIF2fG:yaHHnfS=> M1PNN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEKxO|I6Lz5{NkCyNVczQTxxYU6=
SP2/0 NWrPe4Q{SXCxcITvd4l{KEG|c3H5 Mn7DNVAx|ryP NXPKTIh2OWh? M3nwe2ROW09? M3vLXYJtd2OtczD0bIUh[XCxcITvd4l{KG:oIGPQNk8xKGOnbHzz MmnXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyN{S3N|IoRjJ4MEe0O|MzRC:jPh?=
CEF MkHoT4lv[XOnIFHzd4F6 M4XJNlAtOzNuNkesNVAx|ryP MYixOY1qdg>? NIq5WIxld3ewLYLl[5Vt[XSnczDQVkBmdnq7bXWgZYN1cX[rdImgeI8hPDExvJWgZZQhOTByzszN NIi0U3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGwNlM{QSd-Mk[xNFI{Ozl:L3G+
BEL-7402 M1vXbWFxd3C2b4Ppd{BCe3OjeR?= M4\peVIx|ryP NH;NSpMycA>? MX\heJRmdnWjdHXkJJRp\SCjcH;weI91cWNiaX7keYN1cW:wIH;mJGlKUS1zMNMg NHyz[3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkG2OFc6PSd-Mk[xOlQ4QTV:L3G+
HepG2 NHvBb|dCeG:ydH;zbZMhSXO|YYm= MXeyNO69VQ>? MoHGNYg> Mn;PZZR1\W63YYTl[EB1cGViYYDvdJRwfGmlIHnu[JVkfGmxbjDv[kBKUUlvMUFCpC=> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF4NEe5OUc,OjZzNkS3PVU9N2F-
HGL5 NV7tRZMySXCxcITvd4l{KEG|c3H5 NIfOWHo2OM7:TR?= NYjIRWVzOjSq Mlm0bY5lcWOjdHXzJIEheHKxdHXjeIl3\SCnZn\lZ5Qh[WejaX7zeEBmfG:yb4Pp[IU> NWnheo1jRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xOlkxPzVpPkK2NVY6ODd3PD;hQi=>
GC1a NIf0PJlCeG:ydH;zbZMhSXO|YYm= M1jPVVUx|ryP MnjXNlRp MVTpcoRq[2G2ZYOgZUBxem:2ZXP0bZZmKGWoZnXjeEBi\2GrboP0JIV1d3Cxc3nk[S=> MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF4OUC3OUc,OjZzNkmwO|U9N2F-
A549 MY\BdI9xfG:|aYOgRZN{[Xl? NVPsb2x7OjBizszN NVnQ[JFlOjSq M3fTRpJm\HWlZYOgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhUE[FUDD0doVifG2nboS= NEnZWYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5OFE1QSd-MkW3PVQyPDl:L3G+
HeLa NFXQeXJCeG:ydH;zbZMhSXO|YYm= NH;1OpMyOM7:TR?= NGnaXIY1QGh? M4XVSYRm[2yrbnXzJJRp\SC{YYTlJI9nKGGyb4D0c5NqeyCmcnHtZZRq[2GubIm= NYLOWXU{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3O|I2PDVpPkK1O|czPTR3PD;hQi=>
SGC-7901 M4O2VmFxd3C2b4Ppd{BCe3OjeR?= M33xRVIxyqEQvF2= NHrTeFMycA>? NFnaTWRqdmirYnn0d{B1cGViY3XscEBl\WG2aDDpcoR2[2WmIHL5JI95[WyrcHzheIlv MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd4N{C3Okc,OjV5NkewO|Y9N2F-
MCF-7 NFPyeVJCeG:ydH;zbZMhSXO|YYm= NInlSY0yOM7:TR?= MnW3Nog> MXzpcohq[mm2czD0bIUh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IEPC MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd{MkGxOEc,OjV5MkKxNVQ9N2F-
A549 MlHnRZBweHSxc3nzJGF{e2G7 M{HSZVExKM7:TR?= MYGyOIg> MmnrSG1UVw>? MXXwdo9ud3SnczDIRmMufHKnYYTl[EBCPTR7IHPlcIwhe3W{dnn2ZYwhLiCjdITlcpVifGW|IITo[UBkdGWjdnXkJHBCWlBiZYjwdoV{e2mxbh?= M1G5TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkizOVY5Lz5{NU[4N|U3QDxxYU6=
U87 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWO1NO69VQ>? NYm0TWJ2OWh? M2nhcpJm[2:4ZYLzJINmdGxiZ4Lve5RpKG[{b32gWG1bKHS{ZXH0cYVvfA>? MkDDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OEG2OlgoRjJ3NkixOlY5RC:jPh?=
Neocortical Neuron MXnO[ZVzd3SxeHnjbZR6KEG|c3H5 MVuxNFDPxE1? M4fodlFp NHe0ZplidnSjZ3;ubZpmeyCKb3nhcYll\SCDLVnu[JVk\WRiTnX1do91d3irY3n0fS=> NYrhTGF2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2O|UxODFpPkK1Olc2ODBzPD;hQi=>
Primary human placental cytotrophoblasts NEnHOlJCeG:ydH;zbZMhSXO|YYm= NULOdHpiOzEQvF2= M1vXfFI1cA>? MVnEUXNQ Mkj6doV3\XK|ZYOgeIhmKGmwaHnibZRqd25ib3[gNVHPui2KU1SyJIJ6KHS{aXPsc5NidsLi NYLiNmdtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OFI2QTJpPkK1OlQzPTl{PD;hQi=>
MM MYLBdI9xfG:|aYOgRZN{[Xl? NW\jempwPTEQvF2= NHLvZ3kzOG2rbh?= MUHwZZJ1dHliaX7obYJqfHNiU1jLMYlv\HWlZXSgJINmdGxiZHXheIg> M2jXeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUOwNFk5Lz5{NUWzNFA6QDxxYU6=
DLD1 NF3Ed4FCeG:ydH;zbZMhSXO|YYm= NGnKZWMzOMLizszN MmjDNYg> MXHwZZJ1dHlicnX2[ZJ{\XNiY3XscEBieG:ydH;zbZMh[2G3c3XkJIJ6KFeVUEG= NInxPJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUWyOFI1Pid-MkW1NlQzPDZ:L3G+
MDA-MB-231 MoLZR5l1d3SxeHnjbZR6KEG|c3H5 Mnv0NVDPxE1? M1vF[VFp MYnheYdu\W62czDj[YxtKGSnYYToJIFnfGW{IFPIWWEhfHKnYYTt[Y51 M2nmTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUKxOVAyLz5{NUWyNVUxOTxxYU6=
MKN28 NX3XbIYxSXCxcITvd4l{KEG|c3H5 NGLLcooyOM7:TR?= MVOzNI1qdg>? MYLEUXNQ NUD1Vo5ScW6qaXLpeJMhXE6ILd8xJJBtfXNiQ1jYMYlv\HWlZXSgZZBweHSxc3nz NGnpWHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUWxN|k3OCd-MkW1NVM6PjB:L3G+
HL-60 M4LQb2N6fG:2b4jpZ4l1gSCDc4PhfS=> NGmxVJAyODEQvF2= MonONYg> M13Sc2ROW09? MXdCpIlueHKxdnXzJJZq[WKrbHn0fUBw\iCWQ17Bd{11emWjdHXkJINmdGy| MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTVyMkmzNkc,OjV3MEK5N|I9N2F-
AGS MVvBdI9xfG:|aYOgRZN{[Xl? NYLEdVJVOTEQvF2= M2rDN|Fp MoDrdJJmfmWwdIOgZ5Vz[3WvaX6tbY5lfWOnZDDjcIVifmGpZTDv[kBk[XOyYYPlMVMtKC16LDDhcoQhNTlicILveIVqdnN? MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR7MkKxOEc,OjV2OUKyNVQ9N2F-
A549  MmnrRZBweHSxc3nzJGF{e2G7 NHj6cmwyOM7:TR?= NYi5SYRJOjSq MlTUZoxw[2u|IFTNRXMucW6mdXPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNiYX7kJHBCWlBiYX7kJIFxd3C2b4TpZ{Bk\WyuIHTlZZRp NF7Te|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUSzOFk5QSd-MkW0N|Q6QDl:L3G+
INS-1 NVrnWVFmSXCxcITvd4l{KEG|c3H5 M2DkUlUx|ryP MknZOog> NH3JSGNFVVOR NWnQ[Fln\GWlcnXhd4V{KHSqZTDwdo9xd3K2aX;uJI9nKGWjcnz5JIFxd3C2b4TpZ{Bk\Wyuc9Mg MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR|MEi5O{c,OjV2M{C4PVc9N2F-
Primary hepatocytes  M1;uZ2Fxd3C2b4Ppd{BCe3OjeR?= NIDCfoU2OM7:TR?= M1nrdlE5cA>? MlPrbY5pcWKrdIOgZZBweHSxc3nzJI9nKGincHH0c4N6fGW|IHnu[JVk\WRiYomgRYN1KERiYX7kJHRPTi4QsR?= NFzkOpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUSwO|U{QCd-MkW0NFc2Ozh:L3G+
L929-A  NFvLW5BEgXSxdH;4bYNqfHliQYPzZZk> MUGyNOKh|ryP MoC4NlRp NYnDUHNtcW6qaXLpeJMhXE6IzsGtbY5lfWOnZDDj[YxtKGSnYYTo MkjVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|OUi1OFAoRjJ3M{m4OVQxRC:jPh?=
L929-N M{jBVGN6fG:2b4jpZ4l1gSCDc4PhfS=> MUeyNOKh|ryP Mly1NlRp Ml3a[Y5p[W6lZYOg[IVifGhidnnhJIF2fG:lcnnu[UBVVkcQsTDwdo9lfWO2aX;u NUnQcFRlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzPVg2PDBpPkK1N|k5PTRyPD;hQi=>
Cytotoxicity Assay MoLiR4VtdCCYaXHibYxqfHliQYPzZZk> MkDRNlDPxE1? NWPRTGJqPDiq M3H0WpBz\X[nboSgUWhOTC2rbnT1Z4VlKGOnbHyg[IVifGh? M1nYV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{myNVE3Lz5{NUO5NlEyPjxxYU6=
COS7 NIjPdFdMcW6jc3WgRZN{[Xl? MlXoNVDPxE1? NGDtc24zPGh? NHy1[41qdmO{ZXHz[ZMh[2G|cHHz[UA{NzdiYXP0bZZqfGmncx?= MonCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|OESwNlUoRjJ3M{i0NFI2RC:jPh?=
COS7 NFXFUJZCeG:ydH;zbZMhSXO|YYm= NXraTZJYOTEQvF2= M3nMdFQ5cA>? MUHwZZJ1cWGubImgdJJmfmWwdHXkJGZEOTBzLXnu[JVk\WRiY3XscEBl\WG2aB?= M3nw[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{i0NFI2Lz5{NUO4OFAzPTxxYU6=
A375 NUTMO3N3SXCxcITvd4l{KEG|c3H5 M{n1OlMx|ryP NV60WHB3Omh? MWXwdoV3\W62czD0bIUh\HK3Zz3pcoR2[2WmIGDBVnAh[2ynYY\h[4U> NFTzV5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUO3OlEyPSd-MkWzO|YyOTV:L3G+
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L02 M3XKSWFxd3C2b4Ppd{BCe3OjeR?= NFmwPVIzOM7:TR?= MnTiNYg> MmLodJJmfmWwdIOgeIhmKGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkhVUWKUB?= NWnI[|hxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3NFY1PjFpPkK0O|A3PDZzPD;hQi=>
A375 MWLBdI9xfG:|aYOgRZN{[Xl? M1;6WlIx|ryP NV\oc4ZrOjSq MnjCdoV3\XK|ZYOg[IlkcXS{aX7vcoUhSi2rbnT1Z4VlKGGyb4D0c5Nqew>? NUX3[5lpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2PVkyOTFpPkK0Olk6OTFzPD;hQi=>
HDPC MWLBdI9xfG:|aYOgRZN{[Xl? M1TmS|UxyrWP MlzaNlRp NETtbVVqdmirYnn0d{BPVy2rbnT1Z4VlKGGyb4D0c5Nqew>? NWHqXpdIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2N|Q2QTNpPkK0OlM1PTl|PD;hQi=>
A549 NITUbGFCeG:ydH;zbZMhSXO|YYm= M2nZPFUxyrWP Mn7UNog> NG\mSHZFVVOR MlvadJJmfmWwdIOgeIhmKGi7cH;kbZBtd2mmIFTORUBkd262ZX70JJBp[XOnIHnu[JVk\WRiYomgZ4VxcGGub3Podo9ucW5? M4faV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi4NVM2Lz5{NEW4PFE{PTxxYU6=
 BV-2 NGfCNIZCeG:ydH;zbZMhSXO|YYm= MYWyNO69VQ>? MUGybC=> NU\nXGlje3WycILld5NmeyCXVj3pcoR2[2WmIHPodo9u[XSrbjDlfJRzfXOrb36gZY5lKGSrbHH0bY9vKG:oIITo[UBvfWOuZXHyJIVvfmWub4Dl NVXE[pNjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1OVgyOThpPkK0OVU5OTF6PD;hQi=>
HT-29  MXnBdI9xfG:|aYOgRZN{[Xl? MYG1NO69VQ>? M2O5PVQ5cA>? NIizT2VjdG:la4OgeIhmKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IHvh[Y1x\mW{b3y= M{LSdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUS5NVc2Lz5{NEW0PVE4PTxxYU6=
A549 MYXBdI9xfG:|aYOgRZN{[Xl? NHnjUWU2|ryP MWKyOIg> MkWwd5VxeHKnc4Pld{A3\cLiKFLLNVAxPDBrLXnu[JVk\WRiYYDvdJRwe2m|wrC= Mn;WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3Mkm4O|EoRjJ2NUK5PFcyRC:jPh?=
MIA-PaCa-2 Mn2yRZBweHSxc3nzJGF{e2G7 NXz1[pNYOjSq MWnicI9kc3NiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIlv\HWlZXSgZpkh[m:2aDDBMVQ1OzZ3NDDhcoQheGGlbHn0ZZhmdA>? NICwNHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWxNFk6Oid-MkS1NVA6QTJ:L3G+
Caki-1 NVzGRo1WSXCxcITvd4l{KEG|c3H5 MUeyNO69VQ>? NX\EZVBiOWh? MXTpcohq[mm2czDTR3AucW6mdXPl[EBieG:ydH;zbZM> M{\TWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUC0OlgyLz5{NEWwOFY5OTxxYU6=
CLL NHjCeYhCeG:ydH;zbZMhSXO|YYm= M1LQNFI2|ryP Mlu1NYg> NEHIUYNx[XK2aXHscJkh[myxY3vzJG1NVjJ{M{itbY5lfWOnZDDj[YxtKGGyb4D0c5Nqew>? NVrKXFRMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0Olc3OzRpPkK0OFY4PjN2PD;hQi=>
SGC-7901 NFvobIlCeG:ydH;zbZMhSXO|YYm= NW\GW5FGOTEQvF2= MYeyOIg> MYHwdo9ud3SnczD0bIUhS0eLST3pcohq[mm2ZXSgZ4VtdCCpcn;3eIghcW5iU1fDMVc6ODFiY3XscJM> Ml:zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2NUS0PFgoRjJ2NEW0OFg5RC:jPh?=
k1735 NHHPNopCeG:ydH;zbZMhSXO|YYm= Ml72NlDjiIoQvH2= NEnu[oo1cA>? MmPDbY5pcWKrdIRCpHNidG2xbnXscIEucW6mdXPl[EBieG:ydH;zbZM> Mon0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2NUGxNVYoRjJ2NEWxNVE3RC:jPh?=
HaCaT  MoroRZBweHSxc3nzJGF{e2G7 MU[xNFDPxE1? NIrlUHAycA>? M{frR4JtfW62czDVWmIucW6mdXPl[EBieG:ydH;zbZMhcW5iSHHDZXQh[2WubIO= M1u1dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{W2PVk4Lz5{NEO1Olk6PzxxYU6=
podocytes NIfIeJRCeG:ydH;zbZMhSXO|YYm= NV35c3ZEOjByzszN NFLxXHM3cA>? MYDpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUA{NDRvRFfF NYLxe2RSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzN|c4PzdpPkK0N|M4Pzd5PD;hQi=>
 KB NUDtNFdlSXCxcITvd4l{KEG|c3H5 MkDqOVDPxE1? NIXaTogzPGh? M{joU4lvcGmkaYTzJGxq[29vQT3pcoR2[2WmIHPhd5Bie2VvMzDhcoQhWEGUUDDhZ5RqfmG2aX;u MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN|N{S5Nkc,OjR|M{e0PVI9N2F-
 HepG2  MoflRZBweHSxc3nzJGF{e2G7 MYexNO69VQ>? M4nxRlI1cA>? M3XXNJJm\HWlZYOgeolu\W62aX6gZ4xm[X[jZ3WgZ4F2e2WmIHL5JGxRWw>? Mn3vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|MkW4NVYoRjJ2M{K1PFE3RC:jPh?=
fetal rat lung fibroblasts  NV\aVGxRU2mwYYPlJGF{e2G7 MVS4NO69VcLi M{LT[VFp MmnHbY5pcWKrdIOgR4F{eGG|ZT2zJIFkfGm4aYT5xsA> Mnu5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|MUSxN|UoRjJ2M{G0NVM2RC:jPh?=
PDL fibroblasts MX3LbY5ie2ViQYPzZZk> NH3LXYo5OM7:TdMg NHrh[XMycA>? M4j5SYlvcGmkaYTzJGNie3Cjc3WtN{Bi[3Srdnn0feKh M1XUSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{G0NVM2Lz5{NEOxOFE{PTxxYU6=
MB49 NUiwXYdISXCxcITvd4l{KEG|c3H5 NWD1b4NwOjEQvF2= MmnjNYg> MVjy[ZZmenOnczDDUU1qdmS3Y3XkJINmdGxiZHXheIg> Mmf5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{OEK0N|MoRjJ2MkiyOFM{RC:jPh?=
5637 NHzEU4dCeG:ydH;zbZMhSXO|YYm= MlS3NlDPxE1? NYn3WId3OWh? NVz4ZZVKemW4ZYLz[ZMhS01vaX7keYNm\CClZXzsJIRm[XSq NYPjTnI3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyPFI1OzNpPkK0NlgzPDN|PD;hQi=>
A549  MljRRZBweHSxc3nzJGF{e2G7 NF3DXpYyODEQvF2= NGXVeJY1QGh? MYLzeZBxemW|c3XzJJRp\SCjcH;weI9{cXNiY3H1d4VlKGK7IIDpdIVzcW6nwrC= M3XlSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkeyNlAyLz5{NEK3NlIxOTxxYU6=
MCC-2 MVLBdI9xfG:|aYOgRZN{[Xl? MW[yNEDPxE1? M33l[VZp MVXEUXNQ M3TuT4Jtd2OtczDpcoR2[2WmIHL5JJN1[XW{b4Pwc5JqdmViYYDvdJRwe2m|IHPlcIwh\GWjdHi= NV7YcllDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyOlI3PThpPkK0NlYzPjV6PD;hQi=>
ADF NX[wS|RnSXCxcITvd4l{KEG|c3H5 M3XufFQx|ryP MYG2bC=> M1;YTolvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGOqZX3veIhmemGyeTDwcJV{KFqwQ3yy NY\wTYxSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNlgzOzJpPkK0NlI5OjN{PD;hQi=>
 U373  NGLXSFhCeG:ydH;zbZMhSXO|YYm= NWj5PFR7PDEQvF2= NF2xbYg3cA>? MVrpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkcGWvb4To[ZJieHlicHz1d{BbdkOuMh?= MnvIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{MkiyN|IoRjJ2MkK4NlMzRC:jPh?=
RKO-HIPK2i NUDzeI9ySXCxcITvd4l{KEG|c3H5 MVW0NO69VQ>? MoTkOog> M{DXTYlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGOqZX3veIhmemGyeTDwcJV{KFqwQ3yy MmDWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{MkiyN|IoRjJ2MkK4NlMzRC:jPh?=
HEC-1B NWi1WFVPSXCxcITvd4l{KEG|c3H5 NWL0blViOjEQvF2= M3LFSVFp M2TNeJJm\HWlZYOgWHAucW6mdXPl[EBieG:ydH;zbZPDqGOjc4Dhd4UuOyCjbnSgZ4F{eGG|ZT25 NXHIN|FpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNVM{PThpPkK0NlE{OzV6PD;hQi=>
4T1 M3nMSGNmdGxiVnnhZoltcXS7IFHzd4F6 MnXnNk42NTFyzszN NWjN[3E2PGh? NWS5W2JlTE2VTx?= MnfZdoV{[3WnczD0bIUh[3m2b4TvfIlkcXS7IH;mJFRVOSClZXzsd{BqdmS3Y3XkJIJ6KFOSRGSgbY4h[SClb37j[Y51emG2aX;uJIRmeGWwZHXueEBu[W6wZYK= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJyNkG2NUc,OjR{ME[xOlE9N2F-
OS  MnjoRZBweHSxc3nzJGF{e2G7 NEH0PFczOM7:TR?= M3O5Z|Rp NFrXeFlqdmirYnn0d{B1cGViY3XscEBl\WG2aDDjZZV{\WRiYomgVGRV MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJyNEmzO{c,OjR{MES5N|c9N2F-
RPE MXHBdI9xfG:|aYOgRZN{[Xl? NYLyd3ZPOTByzszN M2LtUVQ5cA>? MXzwZZJ1cWGubImgbY5pcWKrdIOgeIhmKGOjbIDhbY4uOSCjbnSgMVIh[WO2aY\heIlwdiCjczD3[YxtKGG|IITo[UBk[XOyYYPlJIFkfGm4YYTpc44> M1zZT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkCyNFUzLz5{NEKwNlA2OjxxYU6=
UD29a NFXqfohCeG:ydH;zbZMhSXO|YYm= NEHEW4c2OM7:TR?= M2XZTVI1cA>? M162T4lvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHPheZNm\CCkeTDOWXQ{ MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF7MEW3OEc,OjRzOUC1O|Q9N2F-
SH-SY5Y  M4POfmFxd3C2b4Ppd{BCe3OjeR?= NEO0[VcyOM7:TR?= NFf5fnczPGh? MUDheJRmdnWjdHXzJINie3Cjc3WgZYN1cX[jdHnvckBidmRiY3XscEBl\WG2aDDpcoR2[2WmIHL5JGhPTS1{RFe= Ml3VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzNEW0OlMoRjJ2MUS1OFY{RC:jPh?=
HeLa  M1zZVmFxd3C2b4Ppd{BCe3OjeR?= MX2xNE8zOM7:TR?= MmC5NlRp M17P[IlvcGmkaYTzJJRp\SCjY4Tpeol1gSCxZjD0bIUhdWGsb4LpeJkhd2ZidHjlJI1mdWKncoOgc4YhfGinIHPhd5Bie2VvZnHtbYx6 M12yWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUO3NlY3Lz5{NEGzO|I3PjxxYU6=
SCCVII  NV;I[4VDSXCxcITvd4l{KEG|c3H5 MWSyOe69VQ>? NHPYe3EycA>? MV;pcohq[mm2czD0bIUh[2WubDDrbYxtcW6pIHHmeIVzKGSjc3H0bY5q[g>? NHfDN5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGyOlQ3PCd-MkSxNlY1PjR:L3G+
RAW 264.7 MYXBdI9xfG:|aYOgRZN{[Xl? M{jhWlIx|ryP NYrxN4ZHOTiq M4XZcIlv[3KnYYPld{BNSzNvSVmv{tIu[WO2aX6gdoF1cW9iY3;tdIFz\WRidH:gSWNVXi2PT2OgeJJm[XSvZX70JI9vdHl? NUDhdG1KRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxNVY4ODdpPkK0NVE3PzB5PD;hQi=>
A549  NWfkW3pkSXCxcITvd4l{KEG|c3H5 NF:3RZQzNjYQvF2= MXSyOIg> NYjJ[Whb\GWlcnXhd4V{KG:{aXTvcolvNWmwZIXj[YQh[XW2b4DoZYd6KGG|IIflcIwh[W6mIFzvd5Mhd2ZizqVPjI0h[Wy|bzDvZ4N2enKnZDDkeZJqdmdiYYX0c5Bp[WerYzDwdo9k\XO| NGTnWXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGwNlUzOid-MkSxNFI2OjJ:L3G+
UM-SCC-10A  M4jEbGFxd3C2b4Ppd{BCe3OjeR?= M{H3WFUxyrWP NIWyVG0zcA>? MWDy[YR2[2W|IHHwc5B1d3OrczDpcoR2[2WmIHL5JIhq\2hvZH;z[UBqe2:jbHHueI9t[WO2b37l MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB7OEe1N{c,OjRyOUi3OVM9N2F-
BGC-823 M4\LWGFxd3C2b4Ppd{BCe3OjeR?= NYjETVVtOTBizszN NGjyNGkzPGh? NEX4OVZz\WS3Y3XzJJRmfHKjbnTybY5mNWmwZIXj[YQh[XCxcITvd4l{yqB? NFPydGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5PFUyOSd-MkSwPVg2OTF:L3G+
Nalm-6  NGDwU4tCeG:ydH;zbZMhSXO|YYm= MUeyNO69VQ>? NGKxZpo1cA>? M37tRYlvcGmkaYTzJINie3Cjc3WtPEBidmRiY3HzdIF{\S1|IHHjeIl3[XSrb36gZY5lKFCDUmCtNUBkdGWjdnHn[S=> Ml7MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyM{m5OlcoRjJ2MEO5PVY4RC:jPh?=
KHOS  MWjBdI9xfG:|aYOgRZN{[Xl? MYW0NO69VQ>? NYfaSWNkOjSq NGG1c3JjdG:la4OgeIhmKGmwY4LlZZNm\CClbHXheoFo\SCxZjDjZZNx[XOnLUOgZY5lKFCDUmCgbY5lfWOnZDDifUBDSk2GM9Mg MkTmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyMkWzOlEoRjJ2MEK1N|YyRC:jPh?=
G292 NUnnS4ZVSXCxcITvd4l{KEG|c3H5 M1noWlQx|ryP MnLRNlRp Ml7oZoxw[2u|IITo[UBqdmO{ZXHz[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHnu[JVk\WRiYomgRmJOTDQEoB?= NGnCbXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECyOVM3OSd-MkSwNlU{PjF:L3G+
MG-63 NUjwVmk6SXCxcITvd4l{KEG|c3H5 MXm0NO69VQ>? NXLkcJFbOjSq NFjySItjdG:la4OgeIhmKGmwY4LlZZNm\CClbHXheoFo\SCxZjDjZZNx[XOnLUOgZY5lKFCDUmCgbY5lfWOnZDDifUBDSk2GM9Mg MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB{NUO2NUc,OjRyMkWzOlE9N2F-
EBV-transformed B cells NELpeFhCeG:ydH;zbZMhSXO|YYm= NYDiNlNnOjEQvF2= Mo[xNog> NHf1ZoxFVVOR MlKyZoxw[2u|IHHueIkuS0R6MDDhcoQh[W62aT3DSFg3KGGwdHnic4R6NWmwZIXj[YQh[XCxcITvd4l{ NIfFN5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECwPFYzQCd-MkSwNFg3Ojh:L3G+
IM-9 B M3LuV2Fxd3C2b4Ppd{BCe3OjeR?= MUKyNO69VQ>? MYeybC=> Mn3QSG1UVw>? NFTBS3RjdG:la4OgZY51cS2FREiwJIFv\CCjboTpMWNFQDZiYX70bYJw\HlvaX7keYNm\CCjcH;weI9{cXN? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDByOE[yPEc,OjRyMEi2Nlg9N2F-
CNE1 M{TGO2Fxd3C2b4Ppd{BCe3OjeR?= MoXMNlDPxE1? MnOyOFhp MnzUZoxw[2u|IFzLMWEucW6mdXPl[EBieG:ydH;zbZM>