CHIR-99021 (CT99021)

For research use only. Not for use in humans.

目录号:S1263

CHIR-99021 (CT99021) Chemical Structure

CAS No. 252917-06-9

CHIR-99021 (CT99021)是一种GSK-3αGSK-3β抑制剂, IC50分别为10 nM and 6.7 nM。CHIR99201对CDKs没有交叉反应性,对GSK-3β的选择性是对CDKs选择性的350倍。CHIR-99021 可作为Wnt/β-catenin的激活剂并诱导自噬。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 2121.21 现货
RMB 743.57 现货
RMB 1392.56 现货
RMB 4663.62 现货
RMB 7960.29 现货
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客户使用Selleck生产的CHIR-99021 (CT99021)发表文献507篇:

产品安全说明书

GSK-3抑制剂选择性比较

生物活性

产品描述 CHIR-99021 (CT99021)是一种GSK-3αGSK-3β抑制剂, IC50分别为10 nM and 6.7 nM。CHIR99201对CDKs没有交叉反应性,对GSK-3β的选择性是对CDKs选择性的350倍。CHIR-99021 可作为Wnt/β-catenin的激活剂并诱导自噬。
靶点
GSK-3β [1]
(Cell-free assay)
GSK-3α [1]
(Cell-free assay)
6.7 nM 10 nM
体外研究

CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. Furthermore, CHIR-99021 shows only weak binding to a panel of 22 pharmacologically relevant receptors and little inhibitory activity against a panel of 23 nonkinase enzymes. CHIR-99021 induces the activation of glycogen synthase (GS) in insulin receptor-expressing CHO-IR cells with EC50 of 0.763 μM[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LOUCY MnXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjBTWM2OD1zOEKuOlg5KM7:TR?= NYW0R3J6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
SN12C MnTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUj6[IJQUUN3ME2xPFIvQDJ7IN88US=> M{\QSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
A427 NFvMTo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3GzeGlEPTB;MUi0MlY{OSEQvF2= M{fK[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
DOK MmTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvSbZBKSzVyPUG4OE43PDNizszN NV[wUZozRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
MDA-MB-415 MmnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLHNmVKSzVyPUG4OE43PTFizszN M2DWWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
MRK-nu-1 M3\ERmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUToSZRQUUN3ME2xPFQvQTd{IN88US=> NWj3Sm5sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
LB2241-RCC M33hNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfPcGtKSzVyPUG4OU4yPDVizszN MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
NCI-H1563 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vMcGlEPTB;MUi1MlIxQSEQvF2= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
MDA-MB-453 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTF6Nj65OFEh|ryP NXzWSXpXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
MONO-MAC-6 MmGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\3fmlEPTB;MUi3MlM6OiEQvF2= Mln2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
CAPAN-1 NH\SWlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:5TWM2OD1zOEeuOFU{KM7:TR?= NGnCS249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
SK-LU-1 M33sZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT3SndKSzVyPUG4PE41OjhizszN M3zqR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-H1299 NX6ydHBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTF6OD63NVkh|ryP MlzTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
KG-1 NInlTpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXSb5ZKSzVyPUG4PU44QThizszN MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
ETK-1 Mk[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Ls[mlEPTB;MUmwMlE5OSEQvF2= MkDuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
NCI-H838 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\qW4tKSzVyPUG5NE4{PCEQvF2= NWnWXZNvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
HCE-4 MnnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\Mb25KSzVyPUG5NE46QTJizszN M1;xTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
A2780 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTF7Mj64PVEh|ryP NUL4OoNMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
COLO-668 MkjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\jTmFwUUN3ME2xPVMvOTV5IN88US=> MkLkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
HGC-27 NGT6T4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTF7NT61N|gh|ryP M1jt[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
SW1088 NXvFNplZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXMRpRKSzVyPUG5OU43PzdizszN MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
KOSC-2 MkTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfyTVhKSzVyPUG5OU45OThizszN MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
SW780 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HyPGlEPTB;MUm2Mlc{PCEQvF2= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
TE-1 M3LoOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYryXGF{UUN3ME2xPVYvOjZizszN NF;CS3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
22RV1 NGmy[VNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDUTWM2OD1zOUeuOFI1KM7:TR?= NYiyVGNKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
IA-LM M1TRd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fUSWlEPTB;MUm3MlgzOiEQvF2= NHrZOGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
TE-5 M2rYWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nJOGlEPTB;MUm4MlA{OyEQvF2= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
JVM-3 M161V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2O1bmlEPTB;MUm4MlQyQSEQvF2= NVjSNIRNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
HT55 NUfxfnpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHlUGpCUUN3ME2xPVkvOTl{IN88US=> Mn7QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
QIMR-WIL MmH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnG4TWM2OD1{MECuNVE3KM7:TR?= MlToQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
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COLO-679 M1jrS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TUO2lEPTB;MkCwMlg2QSEQvF2= NY[2ZnNCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
MFM-223 NI[wO25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTJyMT61PFch|ryP NHHGcFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
MDA-MB-231 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\hZWlKSzVyPUKwNE46ODJizszN NVnRW|VuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
MFE-280 NFHZ[mhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDvWVlKSzVyPUKwNU46PjFizszN NXmw[ppZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
LAMA-84 NIDtXYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLYTWM2OD1{MEKuNFc{KM7:TR?= M3z6Z|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
LS-1034 NGSxdY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXlTWM2OD1{MEKuOVU{KM7:TR?= MnrjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
NCI-H345 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTJyMz6wNlch|ryP M3jJ[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
KYSE-70 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHVTWM2OD1{MEOuPFc6KM7:TR?= NYXVU2FHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
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RPMI-2650 NIXyN5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTJyNT60Olch|ryP NEPvNpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
NCI-H1651 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTJyNj63N{DPxE1? MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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