CHIR-99021 (CT99021)

For research use only. Not for use in humans.

目录号:S1263

CHIR-99021 (CT99021) Chemical Structure

CAS No. 252917-06-9

CHIR-99021 (CT99021)是一种GSK-3αGSK-3β抑制剂, IC50分别为10 nM and 6.7 nM。CHIR99201对CDKs没有交叉反应性,对GSK-3β的选择性是对CDKs选择性的350倍。CHIR-99021 可作为Wnt/β-catenin的激活剂并诱导自噬。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 2121.21 现货
RMB 743.57 现货
RMB 1392.56 现货
RMB 4663.62 现货
RMB 7960.29 现货
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客户使用Selleck生产的CHIR-99021 (CT99021)发表文献585篇:

产品安全说明书

GSK-3抑制剂选择性比较

生物活性

产品描述 CHIR-99021 (CT99021)是一种GSK-3αGSK-3β抑制剂, IC50分别为10 nM and 6.7 nM。CHIR99201对CDKs没有交叉反应性,对GSK-3β的选择性是对CDKs选择性的350倍。CHIR-99021 可作为Wnt/β-catenin的激活剂并诱导自噬。
靶点
GSK-3β [1]
(Cell-free assay)
GSK-3α [1]
(Cell-free assay)
6.7 nM 10 nM
体外研究

CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. Furthermore, CHIR-99021 shows only weak binding to a panel of 22 pharmacologically relevant receptors and little inhibitory activity against a panel of 23 nonkinase enzymes. CHIR-99021 induces the activation of glycogen synthase (GS) in insulin receptor-expressing CHO-IR cells with EC50 of 0.763 μM[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LOUCY NGTPboFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPvTWM2OD1zOEKuOlg5KM7:TR?= NYDwTXp[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
SN12C MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLoTWM2OD1zOEKuPFI6KM7:TR?= NH[5[nU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
A427 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fyUWlEPTB;MUi0MlY{OSEQvF2= M{D1eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
DOK MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2SzXGlEPTB;MUi0MlY1OyEQvF2= NYnzU4RQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
MDA-MB-415 M37lRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTjZ2t5UUN3ME2xPFQvPjVzIN88US=> MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
MRK-nu-1 M1\yT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTNNmVsUUN3ME2xPFQvQTd{IN88US=> NF\CS4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
LB2241-RCC NVfCeWVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XSbGlEPTB;MUi1MlE1PSEQvF2= NFPI[Wc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
NCI-H1563 NXvKOYhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1yxU2lEPTB;MUi1MlIxQSEQvF2= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
MDA-MB-453 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTF6Nj65OFEh|ryP NYLhbllIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
MONO-MAC-6 MlPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnQVolKSzVyPUG4O{4{QTJizszN MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
CAPAN-1 NHnoOZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLLTWM2OD1zOEeuOFU{KM7:TR?= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
SK-LU-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\3OGlEPTB;MUi4MlQzQCEQvF2= Ml;RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
NCI-H1299 MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLKdIZpUUN3ME2xPFgvPzF7IN88US=> NWLRR4xORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
KG-1 M{jib2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XuNWlEPTB;MUi5Mlc6QCEQvF2= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
ETK-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTqTWM2OD1zOUCuNVgyKM7:TR?= NVPGe4ZvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
NCI-H838 NFTPdGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknPTWM2OD1zOUCuN|Qh|ryP M1HsXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
HCE-4 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnVTWdSUUN3ME2xPVAvQTl{IN88US=> M{nVVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
A2780 NGD2PFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjDZZFKSzVyPUG5Nk45QTFizszN NE\ZSVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
COLO-668 MnLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTF7Mz6xOVch|ryP NIDGSZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
HGC-27 NHvIXXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTF7NT61N|gh|ryP NGe4b2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
SW1088 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfpTWM2OD1zOUWuOlc4KM7:TR?= MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
KOSC-2 M1:5eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTF7NT64NVgh|ryP NX;qXFBjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
SW780 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnrXWZKSzVyPUG5Ok44OzRizszN M{X4UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
TE-1 NFG4WopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVu0WG4{UUN3ME2xPVYvOjZizszN NVjsOW5wRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
22RV1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTF7Nz60NlQh|ryP MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
IA-LM MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfuTWM2OD1zOUeuPFIzKM7:TR?= NI\OcZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
TE-5 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTTPIpKSzVyPUG5PE4xOzNizszN Moe3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
JVM-3 NYXFepNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTF7OD60NVkh|ryP MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
HT55 NG\Yd2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;4RmlEPTB;MUm5MlE6OiEQvF2= NV7aVG1DRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
QIMR-WIL MkPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUP3cplIUUN3ME2yNFAvOTF4IN88US=> M4q4[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
SJRH30 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTJyMD61NVUh|ryP NIPNXHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
COLO-679 NEfZUFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrsW45KSzVyPUKwNE45PTlizszN M4j2N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
MFM-223 NGHTemdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\ldoVKSzVyPUKwNU42QDdizszN MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
MDA-MB-231 MnTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\pbWkxUUN3ME2yNFAvQTB{IN88US=> MmHMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
MFE-280 MmXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTJyMT65OlEh|ryP MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
LAMA-84 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3UVHBKSzVyPUKwNk4xPzNizszN NVrJfZRPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
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NCI-H345 NFHBXmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTHOWZKSzVyPUKwN{4xOjdizszN MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
KYSE-70 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rrb2lEPTB;MkCzMlg4QSEQvF2= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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