CHIR-99021 (CT99021)

For research use only. Not for use in humans.

目录号:S1263

CHIR-99021 (CT99021) Chemical Structure

CAS No. 252917-06-9

CHIR-99021 (CT99021)是一种GSK-3αGSK-3β抑制剂, IC50分别为10 nM and 6.7 nM。CHIR99201对CDKs没有交叉反应性,对GSK-3β的选择性是对CDKs选择性的350倍。CHIR-99021 可作为Wnt/β-catenin的激活剂并诱导自噬。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 2121.21 现货
RMB 743.57 现货
RMB 1392.56 现货
RMB 4663.62 现货
RMB 7960.29 现货
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客户使用Selleck生产的CHIR-99021 (CT99021)发表文献540篇:

产品安全说明书

GSK-3抑制剂选择性比较

生物活性

产品描述 CHIR-99021 (CT99021)是一种GSK-3αGSK-3β抑制剂, IC50分别为10 nM and 6.7 nM。CHIR99201对CDKs没有交叉反应性,对GSK-3β的选择性是对CDKs选择性的350倍。CHIR-99021 可作为Wnt/β-catenin的激活剂并诱导自噬。
靶点
GSK-3β [1]
(Cell-free assay)
GSK-3α [1]
(Cell-free assay)
6.7 nM 10 nM
体外研究

CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. Furthermore, CHIR-99021 shows only weak binding to a panel of 22 pharmacologically relevant receptors and little inhibitory activity against a panel of 23 nonkinase enzymes. CHIR-99021 induces the activation of glycogen synthase (GS) in insulin receptor-expressing CHO-IR cells with EC50 of 0.763 μM[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LOUCY MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDaTWM2OD1zOEKuOlg5KM7:TR?= NYjsenQ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
SN12C MlLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTF6Mj64Nlkh|ryP NIixb5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
A427 MmXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\FdWZKSzVyPUG4OE43OzFizszN M4rLc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
DOK MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTONGtKSzVyPUG4OE43PDNizszN MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
MDA-MB-415 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTF6ND62OVEh|ryP MoT0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
MRK-nu-1 MnXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTF6ND65O|Ih|ryP NHnJcpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
LB2241-RCC M3nwWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vlbGlEPTB;MUi1MlE1PSEQvF2= NHviepM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
NCI-H1563 NWfmc2JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYn1W2Z5UUN3ME2xPFUvOjB7IN88US=> NG\XRmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
MDA-MB-453 M3zJSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PafmlEPTB;MUi2Mlk1OSEQvF2= M{i1e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
MONO-MAC-6 NILiXIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTF6Nz6zPVIh|ryP MlrkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
CAPAN-1 NIezRXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXqTWM2OD1zOEeuOFU{KM7:TR?= MkDOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
SK-LU-1 NV3idVB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37weGlEPTB;MUi4MlQzQCEQvF2= NUPxbXF5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
NCI-H1299 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfaTWM2OD1zOEiuO|E6KM7:TR?= M17HfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
KG-1 NGq0fINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fQXWlEPTB;MUi5Mlc6QCEQvF2= NFK3d4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
ETK-1 M3;Pe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvzTWM2OD1zOUCuNVgyKM7:TR?= M1ezOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-H838 Mm\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTF7MD6zOEDPxE1? MnfpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
HCE-4 NUDydpJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnITWM2OD1zOUCuPVkzKM7:TR?= NHLHRow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
A2780 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLXU5loUUN3ME2xPVIvQDlzIN88US=> M37sVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
COLO-668 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jHZWlEPTB;MUmzMlE2PyEQvF2= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
HGC-27 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDZbmZLUUN3ME2xPVUvPTN6IN88US=> MmKyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
SW1088 M3XIb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fLOmlEPTB;MUm1MlY4PyEQvF2= M13OR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
KOSC-2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTF7NT64NVgh|ryP M2\Qc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
SW780 M3nv[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1n1TWlEPTB;MUm2Mlc{PCEQvF2= MkezQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
TE-1 Mmf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnuTWM2OD1zOU[uNlYh|ryP NX\Lc2lHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
22RV1 MlTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTF7Nz60NlQh|ryP M3PTXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
IA-LM MoTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXGyUI0xUUN3ME2xPVcvQDJ{IN88US=> MlnqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
TE-5 NVLkVpF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULhepdDUUN3ME2xPVgvODN|IN88US=> NIrmbZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
JVM-3 NF6yUmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljtTWM2OD1zOUiuOFE6KM7:TR?= M4rXb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
HT55 M1iweGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljyTWM2OD1zOUmuNVkzKM7:TR?= NUP3OVlLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
QIMR-WIL MlPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvrVXFvUUN3ME2yNFAvOTF4IN88US=> MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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COLO-679 MmXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rrUGlEPTB;MkCwMlg2QSEQvF2= M2XJOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
MFM-223 NYH3SGw5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHTWnVnUUN3ME2yNFEvPTh5IN88US=> MmnMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
MDA-MB-231 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;kbHpUUUN3ME2yNFAvQTB{IN88US=> NYLrR2RlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
MFE-280 MoTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXyVpJKSzVyPUKwNU46PjFizszN M{HGVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
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LS-1034 Mnv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{W3fmlEPTB;MkCyMlU2OyEQvF2= MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
NCI-H345 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjiTWM2OD1{MEOuNFI4KM7:TR?= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
KYSE-70 NGDDUpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF2zdGZKSzVyPUKwN{45PzlizszN M1LkUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
EGI-1 NVTMTHR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYX6dVF4UUN3ME2yNFQvQDN|IN88US=> NFnJO3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
RPMI-2650 NGnqcXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPVTWM2OD1{MEWuOFY4KM7:TR?= NGTZe3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
NCI-H1651 NEXkWopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJyNj63N{DPxE1? M2LoTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
HPAF-II MlfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\afWlEPTB;MkC5MlY4OSEQvF2= NGWwfGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK|5USU6JRWK8M4E,
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