Epirubicin (IMI 28) HCl

For research use only. Not for use in humans.

目录号:S1223 别名: NSC 256942, 4'-epidoxorubicin HCl 中文名称:盐酸表阿霉素

Epirubicin (IMI 28) HCl Chemical Structure

CAS No. 56390-09-1

Epirubicin HCl (IMI 28, NSC 256942, 4'-epidoxorubicin)是阿霉素的半合成L-阿拉伯糖衍生物,通过抑制拓扑异构酶而具有抗肿瘤作用。Epirubicin 可诱导凋亡。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1301.52 现货
RMB 566.18 现货
RMB 2207.25 现货
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客户使用Selleck生产的Epirubicin (IMI 28) HCl发表文献20篇:

产品安全说明书

Topoisomerase抑制剂选择性比较

生物活性

产品描述 Epirubicin HCl (IMI 28, NSC 256942, 4'-epidoxorubicin)是阿霉素的半合成L-阿拉伯糖衍生物,通过抑制拓扑异构酶而具有抗肿瘤作用。Epirubicin 可诱导凋亡。
靶点
Topoisomerase [1]
(Cell-free assay)
体外研究

Epirubicin,与doxorubicin一样,通过与DNA形成复合物而发挥抗肿瘤作用,它会损伤DNA,干扰DNA,RNA以及蛋白质的合成。Epirubicin可能也影响细胞膜的完整性和活性。Epirubicin引起的最大细胞死亡发生在细胞周期的S期。更高浓度下的作用也可见于早期G2以及G1和M期。[1] Epirubicin对大多数癌细胞表现出抗肿瘤活性。Epirubicin对肝癌G2期细胞具有细胞毒性,在24小时时,IC50为1.6 微克/毫升。1.6 微克/毫升 Epirubicin引起Hep G2细胞凋亡,使过氧化氢酶活性增加50%,Se-依赖性谷胱甘肽过氧化物酶活性增加110%,Cu, Zn-超氧化物歧化酶活性增加172%,Mn-超氧化物歧化酶活性增加135%。Epirbicin增加NADPH-CYP 450还原酶在细胞中的表达,并减少GST-π的表达。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H460 MoixR5l1d3SxeHnjbZR6KGG|c3H5 MVu0PEBpenN? MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOR2kuUDR4MDDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODMQvF2u MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTd4N{m3OUc,Ojl5Nke5O|U9N2F-
HepG2 NXrwO3ZWS3m2b4TvfIlkcXS7IHHzd4F6 M1HXcFQ5KGi{cx?= Mn;6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlHPxE1w MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTd4N{m3OUc,Ojl5Nke5O|U9N2F-
MCF10A NYPEZ|F[S3m2b4TvfIlkcXS7IHHzd4F6 MWm0PEBpenN? MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2YyOEFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlHPxE1w NGC3flI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUe2O|k4PSd-Mkm3Olc6PzV:L3G+
NCI-H460 MnXSR5l1d3SxeHnjbZR6KGG|c3H5 M2jBfFQ5KGi{cx?= NV72Onl[S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLVi0OlAh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlEz|ryPLh?= Moq2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzMUmwNlYoRjJ6MUG5NFI3RC:jPh?=
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MCF10A MmHlR5l1d3SxeHnjbZR6KGG|c3H5 MUG0PEBpenN? MkH4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHOTCDIHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC5zM988UU4> NFvrUGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEGxPVAzPid-MkixNVkxOjZ:L3G+
MCF-7 NFq0OpFHfW6ldHnvckBie3OjeR?= NHiyTohEd22yb4Xu[EB4[XNidHXzeIVlKG[xcjDpeJMhfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDidoVie3RiY3HuZ4VzKGOnbHzzLG1ETi15KTygTWM2OD1yLkNOwG0v MkSzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTV2OEiyNEc,QTV2OEiyNFww[T5?
MDA-MB-435 M4foS2N6fG:2b4jpZ4l1gSCjc4PhfS=> M4WxPFQ5KGi{cx?= NVHUW|R1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ{PSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvOjcQvF2u NHruXmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEGxPVAzPid-MkixNVkxOjZ:L3G+
MDA-MB-435 NGi4R4FEgXSxdH;4bYNqfHliYYPzZZk> MXW3NkBpenN? NVe4SXRTS3m2b4TvfIlkcXS7IHnuJIh2dWGwIF3ERU1OSi12M{WgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkK2{txONg>? M2TvWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMkWxOlIyLz5|MUK1NVYzOTxxYU6=
HepG2 MUXDfZRwfG:6aXPpeJkh[XO|YYm= M4DVNVQ5KGi{cx?= MlfBR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjN{zszNMi=> NWPvPZliRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixNVkxOjZpPkK4NVE6ODJ4PD;hQi=>
HCT116 M3vUfGN6fG:2b4jpZ4l1gSCjc4PhfS=> M{jYUFQ5KGi{cx?= MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjN5zszNMi=> NHzzcHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEGxPVAzPid-MkixNVkxOjZ:L3G+
HCT116 MX7DfZRwfG:6aXPpeJkh[XO|YYm= M3f3W|czKGi{cx?= MYLDfZRwfG:6aXPpeJkhcW5iaIXtZY4hUEOWMUG2JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MD6zO:69VS5? M1TWTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMkWxOlIyLz5|MUK1NVYzOTxxYU6=
HCT116 NVjKR4VxS3m2b4TvfIlkcXS7IHHzd4F6 M1jselQ5KGi{cx?= Mn;WR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE41|ryPLh?= MmjSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl5Nke5O|UoRjJ7N{[3PVc2RC:jPh?=
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HEK293T NWf5OnU5S3m2b4TvfIlkcXS7IHHzd4F6 NVPYfplkPzJiaILz M4LqdWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEiHS{K5N3Qh[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JG1VWyCjc4PhfUwhUUN3ME2wMlQ4|ryPLh?= M3\ndlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NU[wOlk2Lz5{N{W2NFY6PTxxYU6=
A549 MnyxR5l1d3SxeHnjbZR6KGG|c3H5 M{fCWFczKGi{cx?= MWHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBOXFNiYYPzZZktKEmFNUC9NE43O87:TT6= M1LidlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NU[wOlk2Lz5{N{W2NFY6PTxxYU6=
MDA-MB-435 MXvDfZRwfG:6aXPpeJkh[XO|YYm= NHvJNnQ1QCCqcoO= MlG0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUSzOUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTBwN988UU4> M2XIUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7N{[3PVc2Lz5{OUe2O|k4PTxxYU6=
MCF7 NEnt[YlEgXSxdH;4bYNqfHliYYPzZZk> M{HyNFczKGi{cx?= MoC1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwQVAvPzIQvF2u M2nv[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NU[wOlk2Lz5{N{W2NFY6PTxxYU6=
HCT116 MV\DfZRwfG:6aXPpeJkh[XO|YYm= Mm\BOkBl[Xm| MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlgz|ryPLh?= NE\OVoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK3OlY4QSd-MkKyO|Y3Pzl:L3G+
MDA-MB-231 MnrOR5l1d3SxeHnjbZR6KGG|c3H5 NXzMVY5YPDhiaILz M1HCbWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkpOwG0v M4fWPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7N{[3PVc2Lz5{OUe2O|k4PTxxYU6=
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HepG2 MlvpR5l1d3SxeHnjbZR6KGG|c3H5 MUi2JIRigXN? MmTtR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3ME2xMlY2|ryPLh?= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ5Nk[3PUc,OjJ{N{[2O|k9N2F-
SNB19 M{WwXmN6fG:2b4jpZ4l1gSCjc4PhfS=> NW\xTGNsPzJiaILz MV7DfZRwfG:6aXPpeJkhcW5iaIXtZY4hW06EMUmgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{LkROwG0v NEj6eYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUK1NVYzOSd-M{GyOVE3OjF:L3G+
MCF7 NUnod|ZYSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NGfC[Wc1QCCqcoO= NIixbm1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1|LkhOwG0v NEPqVIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K4O|A2Pyd-MkOyPFcxPTd:L3G+
NIH/3T3 MV\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MmThOFghcHK| M4SyOGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViTlnIM|NVOyClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUSuNu69VS5? MkPDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{OEewOVcoRjJ|Mki3NFU4RC:jPh?=
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TC32 NHLteHhyUFSVIHHzd4F6 MlzMdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohV3K2aH;nc45idCB|RDD2bYFjcWyrdImgd4Nz\WWwIH\vdkBVSzN{IHPlcIx{ M4nDZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
MG 63 (6-TG R) NVjmVpMyeUiWUzDhd5NigQ>? NX3JTZB4eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiT4L0bI9od26jbDCzSEB3cWGkaXzpeJkhe2O{ZXXuJIZweiCPRzC2N{ApPi2WRzDSLUBk\Wyucx?= MkXBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
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SGC7901 MkHWSpVv[3Srb36gZZN{[Xl? MofHNUBidmRiMUCgeW0> Mo\wNlQhfG9iN{KgbJJ{ MWTJcoR2[3Srb36gc4YhdW:{cHjvcI9ocWOjbDDjbIFv\2W|IHnuJIh2dWGwIGPHR|c6ODFiY3XscJMh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJINmdGxiYoLlZYsh[XRiMTDhcoQhOTBidV2gZYZ1\XJiMkSgeI8hPzJiaILzJIJ6KGmwdnXyeIVlKG2rY4Lvd4NweGmlIHHuZYx6e2m| M3;5O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUCzOlYzLz5{OUmwN|Y3OjxxYU6=
C6 NGrsUZhE\WyuIHP5Z4xmKGG|c3H5 NVHQUJV1OjRiaILz MkjYR4VtdCCleXPs[UBienKnc4SgbY4hemG2IFO2JINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGOnbHygdI9xfWyjdHnvckBifCC|dXKgS|AheGijc3WgcYVie3W{ZXSgZYZ1\XJiMkSgbJJ{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmdiYnHz[YQh\myxdzDjfZRwdWW2comgZY5idHm|aYO= MlHWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF2NEewPFIoRjNzNES3NFgzRC:jPh?=
C6 MkLVR4VtdCCleXPs[UBie3OjeR?= NX3ER2pLOjRiaILz M3vse2NmdGxiY4njcIUh[XK{ZYP0JIlvKHKjdDDDOkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJBweHWuYYTpc44h[XRiR{KvUUBxcGG|ZTDt[YF{fXKnZDDh[pRmeiB{NDDodpMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\yCkYYPl[EBndG:5IHP5eI9u\XS{eTDhcoFtgXOrcx?= M3S1S|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNES3NFgzLz5|MUS0O|A5OjxxYU6=
C6 NGXkb5dE\WyuIHP5Z4xmKGG|c3H5 MU[yOEBpenN? MVvD[YxtKGO7Y3zlJIFzemW|dDDpckBz[XRiQ{[gZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDDwc5B2dGG2aX;uJIF1KFNicHjhd4UhdWWjc4Xy[YQh[W[2ZYKgNlQhcHK|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnegZoF{\WRiZnzve{BkgXSxbXX0dpkh[W6jbInzbZM> NF3JO4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUS0O|A5Oid-M{G0OFcxQDJ:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
HIF-1α / GLUT1 / PDK1 ; 

PubMed: 28339028     


The expression of HIF-1α, PDK1 and glycolysis-related proteins GLUT1, LDHA in 435R cells with/without 2-MeOE2.

FOXM1 / Cyclin B1 / PLK; 

PubMed: 21518729     


MCF-7 and MCF-7-EPIR cells were treated with 1µmol/L of epirubicin for 0, 16, 24 and 48 h. At indicated time, cells were collected and analysed by western blotting to determine the protein expression levels of FOXM1, Cyclin B1, PLK and β-tubulin, and by RT-qPCR to determine FOXM1 mRNA transcript levels.

E2F1 / p-p53 / p53 / Caspase-7 ; 

PubMed: 21518729     


U2OS cells were treated for 0 to 24 h with 1µmol/L of epirubicin in the presence or absence of 5mmol/L of caffeine. At indicated time, cells were collected for western blot analysis to determine the protein expression levels of FOXM1, E2F1, P-p53 (ser15), p53, Cleaved caspase 7 and β-tubulin. 

PARP / E2F1 / p-E2F1 / p-MK2 / p-Chk2 ; 

PubMed: 22802261     


Pretreatment with the p38 inhibitor SB203580 prevents epirubicin-induced E2F1 accumulation and its phosphorylation at Serine 364. U2OS cells were either pretreated with 20 μM SB203580 or untreated and 1h later exposed to 1μM epirubicin. At the times indicated at the top of each lane cells were harvested and proteins extracted from lysates. Equal amounts of protein were used for Western blot analysis with the indicated antibodies. Anti-β-tubulin was immunoblotted as a loading control.

28339028 21518729 22802261
Growth inhibition assay
Cell death ; 

PubMed: 24158003     


KMS20 (left panel) and KMS28BM (right panel) cells were treated with 2ME at the indicated doses for 48 h and subjected to FACS analysis as described above.

24158003
体内研究 Epirubicin对很多类型的肿瘤,包括乳腺癌,恶性淋巴瘤,软组织肉瘤,肺癌,胸膜间皮瘤,胃肠癌,头颈癌,卵巢癌,前列腺癌,移行膀胱癌等都具有临床活性。[3] Epirubicin在3.5毫克/千克剂量下,抑制74.4 %人类乳腺肿瘤异种移植的R-27的肿瘤块。[4]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[2]
- 合并
  • Cell lines: 人类肝肿瘤细胞Hep G2
  • Concentrations: 0.05-12微克/毫升
  • Incubation Time: 1天
  • Method: Hep G2细胞(500细胞/孔,单层)接种于96孔板中。第二天细胞在培养基中用Epirubicin处理。在培养期结束时,加入15%体积的MTT染液。在37℃下培养1小时后,每孔中加入等体积的增溶/终止溶液(dimethylsul-foxide),再培养1小时。记录反应液在570 nm下的吸光度。
    (Only for Reference)
动物实验:[4]
- 合并
  • Animal Models: 人类乳腺异种瘤 R-27
  • Dosages: 3.5毫克/千克
  • Administration: i.v.每4天3次
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (172.41 mM)
Water 100 mg/mL warmed (172.41 mM)
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 579.98
化学式

C27H29NO11.HCl

CAS号 56390-09-1
储存条件 粉状
溶于溶剂
别名 NSC 256942, 4'-epidoxorubicin HCl

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01740271 Recruiting Drug: Epirubicin Breast Neoplasms AHS Cancer Control Alberta December 2012 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

Topoisomerase Signaling Pathway Map

相关Topoisomerase产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID