Fulvestrant (ICI-182780)

For research use only. Not for use in humans.

目录号:S1191 别名: ZD 9238, ZM 182780 中文名称:氟维司琼

Fulvestrant (ICI-182780) Chemical Structure

CAS No. 129453-61-8

Fulvestrant (ICI-182780, ZD 9238, ZM 182780)是一种Estrogen receptor(ER)拮抗剂, 无细胞试验中IC50为0.094 nM。Fulvestrant还可诱导自噬和凋亡并具有抗肿瘤的活性。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 647.01 现货
RMB 567.34 现货
RMB 2233.34 现货
RMB 7289.1 现货
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客户使用Selleck生产的Fulvestrant (ICI-182780)发表文献109篇:

产品安全说明书

Estrogen/progestogen Receptor抑制剂选择性比较

生物活性

产品描述 Fulvestrant (ICI-182780, ZD 9238, ZM 182780)是一种Estrogen receptor(ER)拮抗剂, 无细胞试验中IC50为0.094 nM。Fulvestrant还可诱导自噬和凋亡并具有抗肿瘤的活性。
靶点
ER [1]
(Cell-free assay)
0.94 nM
体外研究

Fulvestrant 有效抑制ER阳性的MCF-7生长(IC50为 0.29 nM),而对ER阴性的的 BT-20人类乳腺癌细胞的生长没有作用效果。Fulvestrant 使细胞在 G0/G1 期累积,也降低了能持续进行DNA合成的细胞比例。[1] Fulvestrant 竞争性地抑制雌二醇与雌激素受体结合。 Fulvestrant通过损害受体二聚化和能量依赖型核质转运,而阻断ER的核定位。由于Fulvestrant-ER复合体的不稳定性,Fulvestrant与ER的结合最终会导致 ER蛋白的加速退化。[2] Fulvestrant (10 nM) 不仅可降低IGF-IR mRNA水平,也降低半衰期。[3] 100 μM Fulvestrant 处理MCF-7细胞,提高TNFR1 和TRADD 稳态的mRNA水平,这种作用具有时间依赖性。[4] Fulvestrant 作用于LNCaP人类前列腺癌细胞,可以下调雄激素受体的表达,也减少雄激素的反应。Fulvestrant也显著降低R1881 刺激的生长,降低 70%。[5]Fulvestrant作用于未成熟的小脑神经元,通过快速激活MAPK,可以调节有丝分裂和细胞死亡。[6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF-7 M1Hmemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nyfFEvOy1zMECwJI5O Mnr3OFghcA>? M2\RdYlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz M1X2TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUe5Nlk1Lz5{NEm3PVI6PDxxYU6=
MCF-7/LTED M{XxWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDMNU4{NTFyMECgcm0> MkP6OFghcA>? Mn3UbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl5OUK5OEc,OjR7N{myPVQ9N2F-
HCC1428 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXjN40yNjNvMUCwNEBvVQ>? NEPKOHY1QCCq MmnFbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> Mn\rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7N{myPVQoRjJ2OUe5Nlk1RC:jPh?=
HCC1428/LTED NUPtZ25oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrZfG96OS5|LUGwNFAhdk1? M1nsWVQ5KGh? NGSx[|NqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? NUDYNZNJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5O|kzQTRpPkK0PVc6Ojl2PD;hQi=>
LCC1 NFrMTFdHfW6ldHnvckBCe3OjeR?= MYWxNFAhdk1? NYLpeZc2PDhvMUS0JIg> M{DR[YFkfGm4YYTld{BWWFJic3nncoFtcW6p NX7YZZh3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4OVgzPzdpPkK0PFU5Ojd5PD;hQi=>
LCC9 NYrkO5l1TnWwY4Tpc44hSXO|YYm= M{e0ZlExOCCwTR?= NUnpb|ZUPDhvMUS0JIg> NFPnZVZi[3SrdnH0[ZMhXVCUIIPp[45idGmwZx?= M2P3VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEW4Nlc4Lz5{NEi1PFI4PzxxYU6=
MCF-7  MmryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXuxNFAhdk1? NInVNGU2KGR? MULpcohq[mm2czDj[YxtKGe{b4f0bEB1dyBzMP-8iS=> NYrOXZVpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4NVk2PTBpPkK0PFE6PTVyPD;hQi=>
mesangial  NUHWe3NwTnWwY4Tpc44hSXO|YYm= M1G5clAvOS1zMECgcm0> NXTCWJNLPDhiaB?= MXjzeZBxemW|c3XzJHRITi4QskGtbY5lfWOnZDD0fZBmKEmYIHPvcIxi\2Ww NGLrdIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe5N|Y{QSd-MkS3PVM3Ozl:L3G+
Mesangial M3XZZ2Z2dmO2aX;uJGF{e2G7 NV;2fnVIOC5zLUGwNEBvVQ>? NGe1PIUxNjViaB?= NH2zd2NqdmirYnn0d{BVT0ZvzsKxMYlv\HWlZXSgV41i\DJicHjvd5Bpd3K7bHH0bY9vKH[rYTDHVGVT NIDMPIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe5N|Y{QSd-MkS3PVM3Ozl:L3G+
ER+ MCF-7/2a MmnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfJTWM2OD1yLkCwOEDPxE1? NXfNUJc3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWzNlQ5QDRpPkG1N|I1QDh2PD;hQi=>
ER+ MCF-7 NEDh[YtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;vcWpFOjByIHi= NUOxfW06UUN3ME2wMlIyKG6P M4HNO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3M{K0PFg1Lz5zNUOyOFg5PDxxYU6=
MCF-7  NFPMUWpHfW6ldHnvckBCe3OjeR?= M3PqOlExyqCwTdMg NX3ZOXJGPzJiaB?= NUKzOlhMemW4ZYLz[ZMhfGinIHXzeJJw\2WwIHXm[oVkfCiLQ{WwJFEvQSEFlzCxNQKJmjliTTm= NVf0SIpLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFg3PTJpPkK0PVA5PjV{PD;hQi=>
MCF-7  M2fUdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTUTWM2OMLib3[gZZBxem:6aX3heIVtgSB{IH7N NWn3d4RXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0OFg{PDZpPkKzOFQ5OzR4PD;hQi=>
H1975  NVjrPXFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVqzxsDPxE1? MmnhNUBu NXLlc5RbcW6lcnXhd4V{KHSqZTDn[YZqfGmwaXKgd4Vve2m2aY\peJkhd2ZiSEG5O|Uh[2WubIRCpC=> NVewOYlmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyOlg5OTBpPkK0NlY5QDFyPD;hQi=>
H1975 MneySpVv[3Srb36gRZN{[Xl? MYCzxsDPxE1? NGjPeI4yKG1? NX;uOFVxfXC{ZXf1cIF1\XNidHjlJIxmfmWuIH;mJGxmfC15Yx?= NGXhXHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK2PFgyOCd-MkSyOlg5OTB:L3G+
MCF-7  NHmwU3dHfW6ldHnvckBCe3OjeR?= NYX0U2RHOTBy4pEJcm3DqA>? NYDndlZEPzJiaB?= NGL2RYNz\X[ncoPld{B1cGVicILveIVkfGm4ZTDl[oZm[3Rib3[gSVLDqGmwIHPlcIwhcW64YYPpc44> NEL5cmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mzOlc4Oyd-MkO5N|Y4PzN:L3G+
MCF-7  NHLI[5JHfW6ldHnvckBCe3OjeR?= NXrtPWdHOTBy4pEJcm3DqA>? NI\jbmgzPC92ODDo NYHrWYNO\mGlaXzpeIF1\XNiaX72ZZNqd25idHjyc5VocCCPTWDzK{Bud2S3bHH0bY9v MoTNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7M{[3O|MoRjJ|OUO2O|c{RC:jPh?=
BT474-tet-shMED1 Mnf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\sR|AvOS13IN88US=> NX\G[G9LPyCm M1nLOYlv[3KnYYPld{AsTG:6IHnu[JVk\WRiY3XscEBl\WG2aDDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= M{\oTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUO2NlM1Lz5{M{mzOlI{PDxxYU6=
ZR75-1-tet-shMED1  NIrJU2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYOwMlEuPSEQvF2= NI\XXYQ4KGR? MYnpcoNz\WG|ZYOgL2RwgCCrbnT1Z4VlKGOnbHyg[IVifGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? NGTseII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mzOlI{PCd-MkO5N|YzOzR:L3G+
MCF-7-tet-shMED1 Mk\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{CwOlAvOS13IN88US=> MVW3JIQ> MUTpcoNz\WG|ZYOgL2RwgCCrbnT1Z4VlKGOnbHyg[IVifGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? NFnmUJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mzOlI{PCd-MkO5N|YzOzR:L3G+
HepG2  M3HGPWZ2dmO2aX;uJGF{e2G7 NGX0fYMxNjBzLUGwJO69VQ>? MoL4NVghcMLi NFv6e4hi[3SrdnH0[ZMhfGinIFXSSU1u\WSrYYTl[EB1emGwc3PybZB1cW:wIH;mJGFHOkWU M4DndVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{OzNVg5Lz5{M{ezN|E5QDxxYU6=
MCF-7L  NXTTVpFpTnWwY4Tpc44hSXO|YYm= MWKxNFAhdk4EoB?= NV3KUYlqOTBibXnuM|I1KGhxNEigbC=> MmLqdoV{fWy2czDpckBGT0[ULDDISXIzKGGwZDDISXI{KHCqb4PwbI9zgWyjdHnvckBifCCycn;sc45o\WRiZYjwc5N2emV? NVrkTVRZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2PFY1OTZpPkKzOlg3PDF4PD;hQi=>
MCF-7L  MWPGeY5kfGmxbjDBd5NigQ>? M1LJ[lExOCCwTdMg NVXve2FoPDhiaB?= NWrCO4pHcW6mdXPld{B2eHKnZ4XsZZRqd25ib3[gcXJPSSCxZjDFS2ZTKGyrZ3Hu[EBJSi2HR1[= NHjobpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[4OlQyPid-MkO2PFY1OTZ:L3G+
MCF-7L MlrWSpVv[3Srb36gRZN{[Xl? NVrPZ25VOTByIH7NxsA> MorBOFghcA>? MnjDbY5lfWOnczDFS2ZTKG[jbXnsfUBu\W2kZYKgZYN1cX[jdHnvckBz\XG3aYLl[EBGWg>? MofOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4OE[0NVYoRjJ|Nki2OFE3RC:jPh?=
C4-12  MXXGeY5kfGmxbjDBd5NigQ>? Ml7vNVAxKG6PwrC= MUm0PEBp M1P1O4lv\HWlZYOgSWdHWiCoYX3pcJkhdWWvYnXyJIFkfGm4YYTpc44hemWzdXny[YQhTVJ? M130[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Nki2OFE3Lz5{M{[4OlQyPjxxYU6=
MCF-7L NV;VfHRzTnWwY4Tpc44hSXO|YYm= NXHVcG16OTByIH7NxsA> MWGyOEBp M1;CO4lv\HWlZYOgSWdHWiCyaH;zdIhwenmuYYTpc44hemWzdXny[YQhUEJvRVfGJIZ2dmO2aX;u NYXxNJZoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2PFY1OTZpPkKzOlg3PDF4PD;hQi=>
MMQ  M1;3bmZ2dmO2aX;uJGF{e2G7 Mn;FNE03OjVibl2= NWPCdVNqPzJiaB?= NGnhPJhld3ewLYLl[5Vt[XSnczD0bIUh\XiycnXzd4lwdiCxZjDld5Rzd2enbjDy[YNmeHSxcj5OtUApTVMQsTm= NHfM[Vk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{WyN|M2Pyd-MkO1NlM{PTd:L3G+
H1975  MlvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\RZW8xNjNzMkWtNVAh|ryP MYS2JIQ> NUfZd4VbcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? Mn61QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|OUm5OVcoRjJ|M{m5PVU4RC:jPh?=
H1975  NVXON5dtSXCxcITvd4l{KEG|c3H5 NUTr[mJvOjByIH7N M1zpfVczKGh? NF7NbJpmdmijbnPld{BmemyxdHnubYIhcW6mdXPl[EBieG:ydH;zbZM> NGfxWmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{O5PVk2Pyd-MkOzPVk6PTd:L3G+
MCF-7  M{jpTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfvNVAwOTByL{GwNFAhdk1? Ml7CNk81NzZiZB?= M{L2[mROW09? NH;scWRqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKGSxc3WtJIFv\CC2aX3lMUBl\XCnbnTlcpQhdWGwbnXy MoXkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MUO1NFYoRjJ|M{GzOVA3RC:jPh?=
MCF-7  NGrRWXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYexNFAhdk1? MVG0JIQ> M2S4Z2ROW09? MV\pcoR2[2W|IHGgbIlocGW{IIDyc5BwenSrb36gc4Yh[2WubIOgbY4hfGinIFexJJBp[XOnwrC= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNzM{WwOkc,OjN|MUO1NFY9N2F-
MLO-Y4  NFjRTYFHfW6ldHnvckBCe3OjeR?= M4XFWFHDqM7:TR?= NVvuZ3FlOSCq M1excYlvcGmkaYTzJGUzNWmwZIXj[YQhS3h2MzDlfJBz\XO|aX;u NVGxcZRGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOFcxPTdpPkKzNlQ4ODV5PD;hQi=>
MCF-7 NHHQZ3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYexNFAhdk1? MlPuOFghcA>? MVHhZpJw\2G2ZYOgeIhmKHC{b3zp[oVz[XSrdnWg[YZn\WO2IH;mJI1w\GW{YYTlJI5qfHKxc3H0bZZmKHO2cnXzdy=> MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJzNke0OEc,OjN{MU[3OFQ9N2F-
TG1-1  M3rxVGZ2dmO2aX;uJGF{e2G7 NEHYdlcyyqEQvF2= NIGwUZUzPCCq MVfhZpJw\2G2ZYOgSVLDqGmwZIXj[YQh[WOldX31cIF1cW:wIH;mJGhKTi1zzsG= MljlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2NFcoRjJ|MEi4OlA4RC:jPh?=
TG1-1  MorUSpVv[3Srb36gRZN{[Xl? MYOxxsDPxE1? NWW2N5o2OjRiaB?= NULr[ZNj[WK{b3fheIV{KEV{wrDpcoR2[2WmIHHjZ5VufWyjdHnvckBw\iCSSUPL MkexQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2NFcoRjJ|MEi4OlA4RC:jPh?=
MCF7 NV3q[|FuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXyxNFAhdk1? MoT3OFghcA>? NXXBNmtGdGWjZIOgeI8h[SC|aX3pcIFzKGyxc4OgbY4he3W{dnn2ZYwh[XNid3n0bEBld3ixcoXibYNqdiCjbH;u[S=> NFLZZYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C3O|I1QSd-MkOwO|czPDl:L3G+
MCF7 NWLYOFl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3nNVAxKG6P MoP2OFghcA>? M3vU[IVvcGGwY3XzJI52fGyrbj3t[YRq[XSnZDDj[YxtKGSnYYTo MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB5N{K0PUc,OjNyN{eyOFk9N2F-
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COS7 M{D6XmZ2dmO2aX;uJIF{e2G7 NF\XbZZCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IHXzeJJw\2WwIILlZ4VxfG:{IHLleIEhdGmpYX7kJIJqdmSrbneg[I9u[WmwIHX4dJJme3OnZDDpckBi\nKrY3HuJIdz\WWwIH3vcotmgSCFT2O3JINmdGy|IHPvMZRz[W6|ZnXjeIVlKHerdHigS4FtPC2OQlSgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDJR|UxKD1iMD6wNFM5KM7:TT6= M3TTSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OE[zNFg{Lz5zOUi2N|A5OzxxYU6=
MCF7 M1rGSGZ2dmO2aX;uJIF{e2G7 NVe0VVZNOjRiaILz M4ewTWlv\HWldHnvckBw\iC|ZXzlZ5RqfmViZYP0do9o\W5icnXj[ZB1d3JiYXzwbIEh\GWpcnHkZZRqd25iaX6gbJVu[W5iTVPGO{Bk\WyuczDoZZJjd3KrbnegWGsuTVKHLVz1Z{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6g[ZN1emGmaX;sMYlv\HWlZXSgS3JGSjFibWLORUBmgHC{ZYPzbY9vKGGodHXyJFI1KGi{czDifUBV[XGPYX6gZZN{[XluIFnDOVAhRSByLkCwN|gh|ryPLh?= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV4MkezO{c,Ojl3NkK3N|c9N2F-
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Rosetta 2 DE3 competent cell M{PtTGZ2dmO2aX;uJIF{e2G7 NU\CbHkzOSCqch?= M1HuXWRqe3CuYXPlcYVvfCCxZjDbN2heNWW|dILh[IlwdCCocn;tJJJm[2:vYnnuZY51KGi3bXHuJG4ufGW{bXnuZYwhUGm|LYTh[4dm\CCHUnHsdIhiKEyERDDoZZJjd3KrbnegR|M5OVNxQ{SxO3MwSzV|MGOgcZV1[W62IHX4dJJme3OnZDDpckBTd3OndIThJFIhTEV|IHPvcZBmfGWwdDDj[YxteyCjZoTldkAyKGi{IHL5JHNRSSCkaX7kbY5oKGG|c3H5MEBKSzVyIE2gNE4xODh2IN88UU4> Mnz5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OU[zPVgoRjJ6Mkm2N|k5RC:jPh?=
HepG2 MWnGeY5kfGmxbjDhd5NigQ>? NHvTV3MyPiCqcoO= M1q1T2Fod26rc4SgZYN1cX[rdImgZZQhWFiUIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJIh2dWGwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDDXXA{STRidILhcpNi[3SrdnH0bY9vKGGodHXyJFE3KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVAhRSBzLkm1JO69VS5? MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ6OEW1PUc,OjN4OEi1OVk9N2F-
MCF7 NYj6NHB[TnWwY4Tpc44h[XO|YYm= M3\mWlExKHWP MWWzJIRigXN? MYXJcohq[mm2aX;uJI9nKGmwY4LlZZNmKGmwIIDyc4xq\mW{YYTpc44hd2ZiZYP0do9o\W5icnXj[ZB1d3JiZYjwdoV{e2mwZzDNR2Y4KGOnbHzzJIF1KDFyIIXNJIFnfGW{IEOg[IF6ew>? M1vzdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Mke1N|E2Lz5zN{K3OVMyPTxxYU6=
MVLN MXfGeY5kfGmxbjDhd5NigQ>? M3zLe|I1KGi{cx?= MknRRYN1cX[rdImgZZQhTVJiYYPz[ZN{\WRiYYOgd5VxeHKnc4Ppc44hd2ZiZYP0do9o\W5icnXzdI9ve2ViZXzlcYVvfC2mcnn2[Y4h\2WwZTD0doFve2GldHn2ZZRqd25iaX6gUXZNViClZXzsd{Bi\nSncjCyOEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6 M4S1W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Mke1N|E2Lz5zN{K3OVMyPTxxYU6=
T47D NYG4NHFGTnWwY4Tpc44h[XO|YYm= NX7vUWxoPSC3TR?= NG[xOpNC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJGVT[WyyaHGgbY4hXDR5RDDj[YxteyCjc4Pld5Nm\CCjczDlcohidmOnbXXueEBw\iCDUEGt[JJqfmWwIITyZY5{[WO2aY\heIlwdiCjdDC1JJVOKGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKgZZN{[XlicnXsZZRqfmVidH:gSG1UVw>? Ml6wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|M{exPFMoRjF5M{O3NVg{RC:jPh?=
MCF7 MojTSpVv[3Srb36gZZN{[Xl? M2Gwc|Q2KG2rboO= NELkOWxDcW6maX7nJIFn\mmwaYT5JJRwKGW|dILv[4VvKHKnY3XweI9zKGGucHjhJIlvKGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBcO0ifRUKgZYNkfW23bHH0bY9vKGGodHXyJFQ2KG2rboOgZpkhf2ixbHWgZ4VtdCClb33w[ZRqfGmxbjDibY5lcW6pIHHzd4F6 MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF|M{e3O{c,OTlzM{O3O|c9N2F-
MCF7 NFvD[IxHfW6ldHnvckBie3OjeR?= MX:yOEBpenN? NIHuOnpFd3ewIILl[5Vt[XSrb36gc4Yh\XO2cn;n[Y4hemWlZYD0c5Ih[WyyaHGg[ZhxemW|c3nvckBqdiCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFI1KGi{czDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN? MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF|M{e3O{c,OTlzM{O3O|c9N2F-
MCF7 NYDHfZp2TnWwY4Tpc44h[XO|YYm= MYSxNFAhdk1? MYmyOEBpenN? NX3aRnF2TG:5bjDy[Yd2dGG2aX;uJI9nKGW|dILv[4VvKHKnY3XweI9zKGGucHjhJIV5eHKnc4Ppc44hcW5iaIXtZY4hVUOINzDj[YxteyCjdDCxNFAhdk1iYX\0[ZIhOjRiaILzJIJ6KGmvbYXuc4ZtfW:{ZYPj[Y5k\SC|dHHpcolv\w>? MnXkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzM{O3O|coRjF7MUOzO|c4RC:jPh?=
MCF7:D5L NVnDPYt7TnWwY4Tpc44h[XO|YYm= M4XlWFEhfU1? M3K0VGFvfGGpb37pd5Qh[WO2aY\peJkh[XRiRWLhcJBp[SCrbjDoeY1idiCPQ1[3PmQ2VCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGVTTS2mZYDlcoRmdnRibIXjbYZmemG|ZTDlfJBz\XO|aX;uJIF1KDFidV2= NE\DN|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUi0OVM5Pid-MUm4OFU{QDZ:L3G+
HEK293 M3n5fmZ2dmO2aX;uJIF{e2G7 MVWxJJVO NETVdIVCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IFXSZoV1[SCrbjDISWszQTNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBGWkVvZHXw[Y5l\W62IHz1Z4ln\XKjc3Wg[ZhxemW|c3nvckBifCBzIIXN NIDiS4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUi0OVM5Pid-MUm4OFU{QDZ:L3G+
Ishikawa NHLvb4tHfW6ldHnvckBie3OjeR?= M3Tx[|EhfU1? NXu2cm1DSW62YXfvcol{fCCjY4Tpeol1gSCjdDDld5Rzd2enbjDy[YNmeHSxcjDpckBpfW2jbjDJd4hqc2G5YTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEWURT3k[ZBmdmSnboSgZYxs[WyrbnWgdIhwe3CqYYThd4UhdGW4ZXzzJIF1KDFidV2= M3i3VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OES1N|g3Lz5zOUi0OVM5PjxxYU6=
HeLa NWLReVZMTnWwY4Tpc44h[XO|YYm= MUGxJJVO MnPmOFghcHK| NXfTOmlFSW62YXfvcol{fCCjY4Tpeol1gSCjdDDoeY1idiCHUnHsdIhiKGW6cILld5Nm\CCrbjDoeY1idiCKZVzhJINmdGy|IHPv[ZhxemW|c3nu[{BGWkVvRUHiMWx2[yCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGW|dILh[IlwdC2rbnT1Z4VlKHS{YX7zZ5JqeHSrb37hcEBi[3SrdnH0bY9vKGG2IEGgeW0h[W[2ZYKgOFghcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigQ>? NVizUHIyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2NlE1QTJpPkKwOlIyPDl{PD;hQi=>
HeLa MmHsSpVv[3Srb36gZZN{[Xl? NEn6RooyODBibl2= MViyNEB1dyB{NDDodpM> M4G4c2FvfGGpb37pd5Qh[WO2aY\peJkh[XRiTFLEJI9nKEWUYXzwbIEhemWlZYD0c5IhcW5iaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDicI9kc2GmZTDv[kBUWkNvMTDibY5lcW6pIITvJJJm[2WydH;yJIF1KDFyMDDuUUBi\nSncjCyNEB1dyB{NDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5 NIDmS2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S0PFM1Pid-MkO0OFg{PDZ:L3G+
MCF7 M4jvSmZ2dmO2aX;uJIF{e2G7 NYOyO2pDOTBibl2= NWXaXWk5PzJiaILz NFjpWmVKdmirYnn0bY9vKG:oIEG3ZoV1[S2nc4TyZYRqd2xvaX7keYNm\CCrbjDFVoFteGijIIDvd4l1cX[nIHj1cYFvKE2FRkegZ4VtdHNicILvcIln\XKjdHnvckBie3Onc4Pl[EBieyCdM1jdMZRpgW2rZHnu[UBqdmOxcoDvdoF1cW:wIHH0JFExKG6PIHHmeIVzKDd{IHjyd{BjgSCuaYH1bYQhe2OrboTpcIxifGmxbjDjc5VvfGmwZx?= NFK1cGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwPFY2Oid-MkS5NFg3PTJ:L3G+
MCF7 MWTGeY5kfGmxbjDhd5NigQ>? M373SFEhfU1? M{\lfVIxKGi{cx?= M3nwbmlv\HWldHnvckBw\iCnc4Tyc4dmdiC{ZXPldJRwei2jbIDoZUBl\We{YXTheIlwdiCrbjDoeY1idiCPQ1[3JINmdGy|IHH0JFEhfU1iYX\0[ZIhOjBiaILzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= MlTmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6N{m0PFUoRjJ3OEe5OFg2RC:jPh?=
MCF7 MWHGeY5kfGmxbjDhd5NigQ>? Mn71NE4xOSC2bzCzNFAhdk1? M{\UUVQ5KGi{cx?= MXPE[Ydz[WSjdHnvckBi[3Srdnn0fUBw\iCHUnHsdIhiKHKnY3XweI9zKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYSgNE4xOSC2bzCzNFAhdk1iYX\0[ZIhPDhiaILzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjRyN{CxNkc,OjZ2MEewNVI9N2F-
Neuro2a NUK2S5pOTnWwY4Tpc44h[XO|YYm= NVW5[FlyOSC3TR?= M{e0WGlvcGmkaYTpc44hd2ZiRGKyOEBqdiCGaHPyO{1l\W[rY3nlcpQhdW:3c3WgUoV2em9{YTDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckA4NUSKQzDs[ZZmdHNiYYSgNUB2VSCkeTDMR{1OWy:JQz3NV{BidmGueYPpdy=> MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OU[1O{c,OjZ5OEm2OVc9N2F-
MCF-7 M{\pb2Z2dmO2aX;uJIF{e2G7 M1\oO|Mhdk1uIEOwJI5ONCB|MECgcm0tKDNidV2= M3[wfVI1KGi{cx?= MYPEc5dvemWpdXzheIlwdiCxZjDFVoFteGijIHnuJIh2dWGwIF3DSk04KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjDld5Rz[WSrb3ytbY5lfWOnZDDHVmVDOSCvUl7BJIxmfmWuczDheEA{KHhiMUCnMVkhVSxiMzD4JFExLy16IF2sJFMhgCBzMDetO{BONCB|IIigNVAoNTZiTTDh[pRmeiB{NDDodpMh[nliUmStVGNTKG2ndHjv[C=> M1rNWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkW3N|IxLz5{OE[1O|MzODxxYU6=
MCF-7 MWfGeY5kfGmxbjDhd5NigQ>? MXWzJI5ONCB|MDDuUUwhOzByIH7NMEA{KHWP NVLvVHFkOjRiaILz M{TP[2Rwf26{ZXf1cIF1cW:wIH;mJGVT[WyyaHGgbY4hcHWvYX6gUWNHNTdiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJIV{fHKjZHnvcE1qdmS3Y3XkJHBoWiCvUl7BJIxmfmWuczDheEA{KHhiMUCnMVkhVSxiMzD4JFExLy16IF2sJFMhgCBzMDetO{BONCB|IIigNVAoNTZiTTDh[pRmeiB{NDDodpMh[nliUmStVGNTKG2ndHjv[C=> MoTNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4NUezNlAoRjJ6NkW3N|IxRC:jPh?=
MCF-7 M3[xSmZ2dmO2aX;uJIF{e2G7 NVH3enRCOyCwTTygN|Ahdk1uIEOwNEBvVSxiMzD1US=> MXGyOEBpenN? NYr4[HpMTG:5boLl[5Vt[XSrb36gc4YhTVKjbIDoZUBqdiCqdX3hckBOS0ZvNzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yh\XO2cnHkbY9tNWmwZIXj[YQheFN{IH3SUmEhdGW4ZXzzJIF1KDNieDCxNEcuQSCPLDCzJJghOTBpLUigUUwhOyC6IEGwK{04KE1uIEOgfEAyOCdvNjDNJIFnfGW{IEK0JIhzeyCkeTDSWE1RS1JibXX0bI9l Mkf2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4NUezNlAoRjJ6NkW3N|IxRC:jPh?=
MCF7 NUexNpFzTnWwY4Tpc44h[XO|YYm= MnXONVAhfU1? MofCNlQhcHK| MnLpTY5lfWO2aX;uJI9nKHOnbHXjeIl3\SCnc4Tyc4dmdiC{ZXPldJRweiCjbIDoZUBl\We{YXTheIlwdiCrbjDoeY1idiCPQ1[3JINmdGy|IHH0JFExKHWPIHHmeIVzKDJ2IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= M1v4dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NU[yO|M4Lz5{OUW2Nlc{PzxxYU6=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
MDM2 / ER; 

PubMed: 24747123     


MCF7 (A) and T47D (B) cells were cultured in the presence of different concentrations of fulvestrant (Fulv) for 66 h. ER and MDM2 were detected by Western blot and normalized to β-actin. The decrease in protein expression (shown relative to vehicle control treatment) after fulvestrant treatment was calculated for each drug concentration. *P < 0.05 compared to vehicle control treatment. 

p-ErbB3 Y1289 / ErbB3 / p-ErbB4 Y1056 / ErbB4 / p-AKT / AKT / p-ERK / ERK; 

PubMed: 21396094     


Western blots showing the effect of increasing concentrations of heregulin β1 (HRGβ1) (0.1 to 10 ng/ml for five minutes) on total and phosphorylated ErbB3, ErbB4, AKT and extracellular signal-regulated kinases 1 and 2 (ERK1/2) protein expression in MCF-7 and T47D cells, maintained for 7 days in the presence of either fulvestrant (100 nM) of vehicle control (ethanol). 

ErbB3; 

PubMed: 23999432     


Immunofluorescence of ErbB3 in cells cultured for 24 hours with or without fulvestrant. 

ERα; 

PubMed: 19815064     


Breast cancer cells were treated with different doses of ICI for 3 hours. The expression levels of ERα and actin were assayed by Western blot using anti-ERα and anti-actin antibodies.

24747123 21396094 23999432 19815064
Immunofluorescence
IGF-1R / Erα; 

PubMed: 19815064     


Confocal microscope study of fulvestrant-induced ERα and IGF-1R co-localization on the cell membrane in non-permeabilized condition. Cells were starved in 1% DCC medium for 24 hr and then treated with either vehicle (left) or ICI at 100 nM (right) for 15 min. Treated cells were fixed in 4% formaldehyde and stained with mouse monoclonal anti-IGF-1R antibody (a), rabbit polyclonal anti-ERα antibody (b), or nuclear staining with DAPI (c). The merged images are shown in d. Scale bar = 20 μm.

Snail / E-cadherin ; 

PubMed: 23936773     


E-cadherin and Snail protein localization in MCF-7 cells 48 h after treatment of cells with E2 and the tested agents. C: control (untreated cells); E2: cells treated with 17β-estradiol; Fulv: cells treated with E2 + 100 nM Fulv. The image is representative of three independent experiments using a magnification of 63X.

19815064 23936773
Growth inhibition assay
Cell viability; 

PubMed: 29787591     


MTT assay of MCF-7 cells treated with various concentration of fulvestrant. Statistically significant reduced the % viability in MCF-7 cells (One-way ANOVA; ****p < 0.0001).

29787591
体内研究 Fulvestrant缺乏子宫活性,与雌二醇联用皮下注射给药未成熟的雌性大鼠,有效抑制雌二醇的子宫内活性,ED50 为0.06 mg/kg/day。5 mg Fulvestrant悬浮液皮下注射到MCF-7移植瘤中,完全抑制肿瘤生长。10 μM Fulvestrant也有效抑制BrlO人类乳腺癌移植瘤的生长。[1] Fulvestrant (10 mg/rat) 皮下注射到大鼠前列腺腹侧,降低雄激素受体的表达,ERK1/2磷酸化,和细胞增殖。[7]Fulvestrant作用于鸡胚绒毛尿囊膜还具有抗血管生成的作用效果。[8]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[1]
- 合并
  • Cell lines: MCF-7 乳腺癌细胞
  • Concentrations: 2.9 nM
  • Incubation Time: 5 天
  • Method: MCF-7细胞培养在多孔板中(24孔,按4 × 104密度为接种),孔中含基本必需培养基,培养基中包含酚红,胰岛素(10 μg/mL),和5%活性炭处理的胎牛血清,不含额外的雌二醇。接种2天后,在新鲜的培养基中加入Fulvestrant 和/或雌二醇。培养持续5天,且进一步改变培养基,通过在实验处理开始和结束测量全部细胞蛋白,且与只用乙醇(0.1%)处理的对照组进行比较后,测评生长状况。
    (Only for Reference)
动物实验:[6]
- 合并
  • Animal Models: 携带人类乳腺癌移植瘤MCF-7的裸鼠
  • Dosages: 5 mg
  • Administration: 皮下注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL (164.8 mM)
Water Insoluble
Ethanol '''100 mg/mL
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
0.4mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 606.77
化学式

C32H47F5O3S

CAS号 129453-61-8
储存条件 粉状
溶于溶剂
别名 ZD 9238, ZM 182780

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05191004 Not yet recruiting Drug: NUV-422|Drug: Fulvestrant Advanced Breast Cancer|Metastatic Breast Cancer|Breast Cancer|Breast Carcinoma|Cancer of the Breast|Cancer of Breast|Malignant Tumor of Breast|Breast Tumor Nuvation Bio Inc. March 2022 Phase 1|Phase 2
NCT05082025 Not yet recruiting Drug: Copanlisib|Drug: fulvestrant Endometrial Cancer|Ovarian Cancer M.D. Anderson Cancer Center|Bayer February 28 2022 Phase 2
NCT05181033 Not yet recruiting Drug: Lenvatinib + Letrozole|Drug: Fulvestrant Breast Cancer National University Hospital Singapore|Eisai Co. Ltd. January 2022 Phase 2
NCT05135104 Not yet recruiting Drug: Palbociclib Metastatic Breast Cancer Asociatia Oncohelp - Centrul de Oncologie Oncohelp|MDX Research November 15 2021 --
NCT05022342 Recruiting Other: alpelisib plus fulvestrant Breast Cancer Novartis Pharmaceuticals|Novartis October 27 2021 --

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    Is there any information for the half-life of fulvestrant (Cat No.S1191)?

  • 回答:

    S1191, is about 13.5 to 18.5 hours in vivo: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750771/. The half life of these compounds in cell culture might be different and we generally recommend replenishing with fresh drug every 24-48 hours.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID