Imatinib (STI571) Mesylate

For research use only. Not for use in humans.

目录号：S1026 别名： Gleevec, Glivec, CGP-57148B 中文名称：甲磺酸伊马替尼

Imatinib (STI571) Mesylate Chemical Structure

CAS No. 220127-57-1

Imatinib Mesylate (STI571, CGP-57148B)是一种口服生物有效的Imatinib甲磺酸盐，是一种多靶点抑制剂，作用于v-Abl，c-Kit和PDGFR，在无细胞和细胞试验中，IC50分别为0.6 μM，0.1 μM 和0.1 μM。Imatinib Mesylate (STI571) 可诱导自噬。

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10mM (1mL in DMSO)	RMB 1567.38	现货
100mg	RMB 780.01	现货
250mg	RMB 1603.82	现货
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客户使用Selleck生产的Imatinib (STI571) Mesylate发表文献167篇：

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产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

产品描述

靶点

PDGFR ^[1] (Cell-free assay)	c-Kit ^[2] (M-07e cells)	v-Abl ^[1] (Cell-free assay)
100 nM	100 nM	600 nM

体外研究

抑制酪氨酸和丝氨酸/苏氨酸蛋白激酶的体外测定法显示Imatinib有效抑制V-Abl酪氨酸激酶和PDGFR，IC50分别为0.6 μM和0.1 μM。^[1] Imatinib抑制SLF-依赖性激活的野生型的c-kit激酶活性，IC 50约为0.1 μM，这类似抑制PDGFR所需的浓度。^[2] Imatinib表现出对人支气管类癌细胞系NCI-H727和人胰腺类癌细胞系BON-1的抑制作用，IC50分别为32.4 μM和32.8 μM。 ^[3] 最近的一项研究显示，Imatinib通过下调hERG1 K(+)通道发挥在慢性粒细胞白血病的抗白血病作用，hERG1 K(+)通道在白血病细胞中高表达并表现有利于白血病出现。^[4]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
GIST882	NEOxOI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M1TBfVk3KGh?	MorNTWM2OD1zLkeg{txO	NHf0R4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFIyOid-MkS5NFAzOTJ:L3G+
K562	MWfDfZRwfG:6aXPpeJkhSXO\|YYm=		NETQXYQzPCCq	MXrJR\|UxRTBwMkGg{txO	M2jnZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MECwNlA4Lz5{MkCwNFIxPzxxYU6=
MCF-7	NFrQWYFEgXSxdH;4bYNqfHliQYPzZZk>		NIfTW3kzPCCq	NFTSVnBKSzVyPUCuPFMh\|ryP	NH\DZW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkCwNFIxPyd-MkKwNFAzODd:L3G+
MDA-MB-23	MVrDfZRwfG:6aXPpeJkhSXO\|YYm=		M4fpe\|I1KGh?	MUPJR\|UxRTFwODFOwG0>	MnW5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMECyNFcoRjJ{MECwNlA4RC:jPh?=
K562r	NWXUeXhMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NFrOS2FKSzVyPUGwxsDPxE1?	NHLZT3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmzPVQyQCd-MkS5N\|k1OTh:L3G+
K562	M3fiNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M4W5bmVEPTB;MD6wPUDPxE1?	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjZ5OESxOEc,OTZ4N{i0NVQ9N2F-
MCF-7	NXfOWJFCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUGxNEDPxE1?	M1XOTFQ5KGh?	M4[5XYJtd2OtczDj[YxtKHC{b3zp[oVz[XSrb36gbY5kemWjc3WgbY5lfWOnZDDifUBDUjOc	MlTKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{N{SwN\|QoRjJ3Mke0NFM1RC:jPh?=
K-562	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MY\JR\|UxRTFizszN	MmXzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{M{m2OlIoRjJ3MkO5OlYzRC:jPh?=
K562	MoTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NWrhdZJ1UUN3ME2wMlXDqM7:TR?=	NXH2dlZNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5N\|k1OThpPkK0PVM6PDF6PD;hQi=>
PC3	NVvsSYJKSXCxcITvd4l{KEG\|c3H5	NX33VY5lOjEkgJpOwG0>	NYfuSYd7PDhxN{KgbC=>	M3Ppe4lv[3KnYYPld{Bk\WyuIIP1dpZqfmGu	NUfIWZRpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PFY3PTZpPkK1O\|g3PjV4PD;hQi=>
PC3	NIPoXphE\WyuIG\pZYJqdGm2eTDBd5NigQ>?	MV:yNQKBkc7:TR?=	MoXkOk04OiCq	NIjOeolqdmO{ZXHz[ZMh[2WubDD2bYFjcWyrdIm=	Ml74QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5OE[2OVYoRjJ3N{i2OlU3RC:jPh?=
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GIST882	MojKSpVv[3Srb36gZZN{[Xl?			M4fveGlvcGmkaYTpc44hd2ZiS1nUJGs3PDKHIH31eIFvfCCjdYTvdIhwe3Cqb4L5cIF1cW:wIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJIh2dWGwIFfJV3Q5QDJiY3XscJMh[nliRVzJV2EtKEmFNUCgQUAxNjB7NzFOwG0v	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzMUe3NUc,OjN4MUG3O\|E9N2F-
insect	NYfxOW5STnWwY4Tpc44h[XO\|YYm=		MXyzNEBucW6\|	MlPaTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCC5aXzkJJR6eGViQVLMNUBmgHC{ZYPz[YQhcW5iaX7z[YN1KGOnbHzzJIFnfGW{IEOwJI1qdnNiYomgSnJGXCCjc4PhfUwhUUN3MDC9JFAvODl6MjFOwG0v	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN\|MEG3NFM9N2F-
K562	NUG3TZFFS3m2b4TvfIlkcXS7IHHzd4F6		Mn;ZO\|IhcHK\|	MnXwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSByLkGg{txONg>?	NFLmdmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
primary leukemia cells	NI\vW3lEgXSxdH;4bYNqfHliYYPzZZk>		M4PJS\|czKGi{cx?=	M{Pzd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJBzcW2jcomgcIV2c2WvaXGgZ4VtdHNiaYPvcIF1\WRiZoLvcUBi[3W2ZTDtfYVtd2mmIHzleYtmdWmjIIDheIlmdnRiZYjwdoV{e2mwZzD3bYxlKHS7cHWgSmxVOyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhdHWlaX\ldoF{\SCjc4PhfUwhUUN3MDC9JFAvOSEQvF2u	NUL1RotNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNlEzODFpPkKyNlIyOjBzPD;hQi=>
BV173	MkW4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NWm1TYRxPDhiaILz	NYTybG9ESW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCWlE4OyClZXzsd{Bi\nSncjC0PEBpenNiYomgR4VtdC2WaYTldk1IdG9ibIXtbY5me2OnboSgZ4VtdCC4aXHibYxqfHliYYPzZZktKEeLNUCgQUAxNjFizszNMi=>	MkjDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUGxOVkoRjJ5MEGxNVU6RC:jPh?=
BAF3	Ml;sSpVv[3Srb36gZZN{[Xl?		M{nrdlczKGi{cx?=	MoDGTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEBNPTZ5UDDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W\|ZTDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{9ES0t6IHHzd4F6NCCJSUWwJF0hOC5zIN88UU4>	NITRfGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
K562	MVfDfZRwfG:6aXPpeJkh[XO\|YYm=		Mme0NlQhcHK\|	NF2zRoJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjFizszNMi=>	NV\vT5JQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2N\|I6OzVpPkKyOlMzQTN3PD;hQi=>
BA/F3	NIDke5pHfW6ldHnvckBie3OjeR?=		MXW3NkBpenN?	M{nWdGlvcGmkaYTpc44hd2ZiVFXMMYZ2e2WmIGDES2ZT[mW2YTCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJCN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDDndo94fGhiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCJSUWwJF0hOC5zMEKg{txONg>?	MmXKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BAF3	NXn0T\|hsTnWwY4Tpc44h[XO\|YYm=		M3HTWlczKGi{cx?=	MoXBTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiYz3LTXQhVDV5NmCgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJGJCTjNiY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25ibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONODDhd5NigSxiR1m1NEA:KDBwMUCyJO69VS5?	NHn2[2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
GIST882	MYfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			M4f0T2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1nTWFg5OiClZXzsd{whUUN3MDC9JFAvOTB6IN88UU4>	MoLmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N\|goRjJyOEG3OVM5RC:jPh?=
GIST882	NYnwRoE6TnWwY4Tpc44h[XO\|YYm=			MUTJcohq[mm2aX;uJI9nKEuLVDDLOlQzTSCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iaIXtZY4hT0mVVEi4NkBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHL5JGFVWC2mZYDs[ZRqd25iYYPzZZktKEmFNUCgQUAxNjFyODFOwG0v	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzMUe3NUc,OjN4MUG3O\|E9N2F-
K562	NXvhd5o6S3m2b4TvfIlkcXS7IHHzd4F6			Ml\MR5l1d3SxeHnjJIVn\mWldDDpckBMPTZ{IHPlcIx{NCCLQ{WwJF0hOC5zMTFOwG0v	M{PubVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OUWxNVE{Lz5zMkm1NVEyOzxxYU6=
KU812	MmDwRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NYj1WWNWPzJiaILz	MYrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEuXOEGyJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHygeIl1\XJvZ3zvJIF{e2G7LDDHTVUxKD1iMD6xNUDPxE1w	Ml\TQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
BA/F3	NFrMbmtCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MWK3NkBpenN?	M3mwW2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW\|c3nu[{BD[3JvQXLsJGg{QT[SIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSByLkGxJO69VS5?	MmPIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ\|MEi4OlQ1RC:jPh?=
BAF3	M33hd2Z2dmO2aX;uJIF{e2G7		MV:3NkBpenN?	NF;sOINKdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDDV2YyWiBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKG2nYYP1doVlKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUzhiYYPzZZktKEeLNUCgQUAxNjFzIN88UU4>	M2KxZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
32D	M4PMemFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NYfCW5RwPDhiaILz	NHK4OZdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIEOySEBk\WyuczD0doFve2[nY4Tl[EB4cXSqIICyNVAh[2WubIOg[ZhxemW\|c3nu[{BD[3JvYXLsJIF{e2W\|c3XkJIF{KHC{b3zp[oVz[XSrb36gZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNVEzKM7:TT6=	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjRzNUi2N{c,OTZ2MUW4OlM9N2F-
insect cells	M2W0cGZ2dmO2aX;uJIF{e2G7		MVezNEBucW6\|	MYPJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEGETEGgUVM2OVRibYX0ZY51KGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMh[W[2ZYKgN\|AhdWmwczDifUBHWkWWIHHzd4F6NCCLQ{WwJF0hOC5zMUSzJO69VS5?	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN\|MEG3NFM9N2F-
insect cells	Ml;jSpVv[3Srb36gZZN{[Xl?		MofXN\|AhdWmwcx?=	M3;GeGlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiQVLMNUBSOjV{SDDteZRidnRiZYjwdoV{e2WmIHnuJIlve2WldDDj[YxteyCjZoTldkA{OCCvaX7zJIJ6KE[URWSgZZN{[XluIFnDOVAhRSByLkGxOUDPxE1w	NUf1bGtURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
K562	MXXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MkLvO\|IhcHK\|	MkDVRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDCR3IuSUKOIHTldIVv\GWwdDDoeY1idiCNNU[yJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD6xNkDPxE1w	MlTuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
BA/F3	NH\yR3JCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MYS3NkBpenN?	M1;CRWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW\|c3nu[{BD[3JvQXLsJG0zPDSYIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSByLkGyPUDPxE1w	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB6OE[0OEc,OjNyOEi2OFQ9N2F-
K562	Ml;lRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NYLTOnRQPzJiaILz	MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONLUigZZN{[XluIFfJOVAhRSByLkG0JO69VS5?	NWnteGdnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3PFk2PTNpPkK2O\|g6PTV\|PD;hQi=>
HEK293	NXX1eYY6TnWwY4Tpc44h[XO\|YYm=			NIHOboFKdmirYnn0bY9vKG:oIHH1eI9xcG:\|cHjvdplt[XSrb36gc4YhTESUMjDlfJBz\XO\|ZXSgbY4hUEWNMkmzJINmdGy\|IHL5JGVNUVODLDDJR\|UxKD1iMD6xOFEh\|ryPLh?=	MlrXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N\|goRjJyOEG3OVM5RC:jPh?=
K562	NEf0WnJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M2rKWVczKGi{cx?=	MlXxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHygeIl1\XJvZ3zvJIF{e2G7LDDHTVUxKD1iMD6xOFch\|ryPLh?=	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV2MU[5OUc,Ojh3NEG2PVU9N2F-
BAF3	NF\tcIhHfW6ldHnvckBie3OjeR?=		NFHuNIQ4OiCqcoO=	NH25dYpKdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDjT2lVKEF6MknQJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W\|ZTDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG\|c3H5MEBIUTVyIE2gNE4yPDh{IN88UU4>	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV2MU[5OUc,Ojh3NEG2PVU9N2F-
Ba/F3	MXzGeY5kfGmxbjDhd5NigQ>?		MornOFghcHK\|	NHXLVpNKdmirYnn0bY9vKG:oIFLDVk1CSkxzIFWzOVVIKG23dHHueEApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCvb4Xz[UBD[S:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEKFUj3BRmwyNW2nZHnheIVlKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkA1QCCqcoOgZpkhSnKrdHXMbYdpfCCudXPp[oVz[XOnIHHzd4F6NCCJSUWwJF0hOC5zNEmg{txONg>?	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF\|N{m4NUc,OzBzM{e5PFE9N2F-
KU812	NWLWPZJnSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MkTXO\|IhcHK\|	M{\IXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS2W4NVIh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO\|YYmsJGdKPTBiPTCwMlE3KM7:TT6=	Mo\RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm1OVMoRjJ4N{i5OVU{RC:jPh?=
KU812	MmizRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NGjWXVY4OiCqcoO=	NVTxNY1zSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBDS1JvQVLMJIRmeGWwZHXueEBpfW2jbjDLWVgyOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFAvOTZizszNMi=>	NWe3O\|VIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
A10	MorkSpVv[3Srb36gZZN{[Xl?		Mom1OlghcHK\|	M3HLZWlvcGmkaYTpc44hd2ZiUFTHSnIu[mW2YTDkdol3\W5icILvcIln\XKjdHnvckBw\iC{YYSgRVExKGOnbHzzJIFnfGW{IE[4JIhzeyCrbjDwdoV{\W6lZTDv[kBz[XRicnXjc41jcW6jboSgVGRITi2EQjDifUBk\WyuIITpeIVzNWeubzDseY1qdmW\|Y3XuZ4Uh[XO\|YYmsJGlEPTBiPTCwMlE3OiEQvF2u	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzVyMkewNEc,Ojd3MEK3NFA9N2F-
KU812	NEH6VYZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NVzSRpVmPzJiaILz	NH\z[YlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFvVPFEzKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT\|gh[XO\|YYmsJGdKPTBiPTCwMlE3OyEQvF2u	NXz4VpdXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
K562	MkDyR5l1d3SxeHnjbZR6KGG\|c3H5			NV3mXYxYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyxiSVO1NEA:KDBwMUeg{txONg>?	NGK4[Gk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNFgxPid-MkO2NFA5ODZ:L3G+
K562	M1T2[mFvfGmycn;sbYZmemG2aY\lJIF{e2G7			M370[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczygS2k2OCB;IECuNVch\|ryPLh?=	NUDCSWxPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N\|k3PzRpPkKyOFM6Pjd2PD;hQi=>
insect cells	NYft[HVRTnWwY4Tpc44h[XO\|YYm=		NIPPdIs{OCCvaX7z	NUDvcJoxUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDBRmwyKEh\|OU\QJI12fGGwdDDlfJBz\XO\|ZXSgbY4hcW6\|ZXP0JINmdGy\|IHHmeIVzKDNyIH3pcpMh[nliRmLFWEBie3OjeTygTWM2OCB;IECuNVc{QSEQvF2u	NFXKUHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
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K562	M3LQSmFvfGmycn;sbYZmemG2aY\lJIF{e2G7			M3jmd2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgT\|U3OiClZXzsd{whUUN3MDC9JFAvOTh{IN88UU4>	MmH3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ\|M{K0OFAoRjF4M{OyOFQxRC:jPh?=
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K562	Mn\vRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MXG0PEBpenN?	MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KHS{eYDhckBjdHWnIHT5[UBmgGOudYPpc44h[XO\|YYmsJGlEPTBiPTCwMlIzKM7:TT6=	NYC0S3RDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2Nlk5PTlpPkK2OlI6QDV7PD;hQi=>
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CHO	NInQbYFHfW6ldHnvckBie3OjeR?=			MX3Jcohq[mm2aX;uJI9nKHerbHSgeJlx\SCSbHH0[YxmfC2mZYLpeoVlKGe{b4f0bEBn[WO2b4KgdoVk\XC2b4KgZoV1[SCyaH;zdIhwenmuYYTpc44hcW5iQ1jPJINmdGy\|LDDJR\|UxKD1iMD6yOEDPxE1w	NFfHS489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkG2Olk2OCd-MUKxOlY6PTB:L3G+
MEG01	M33CNmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NGrnOlE4OiCqcoO=	MoXzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPRVewNUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1utPEBie3OjeTygS2k2OCB;IECuNlQh\|ryPLh?=	M1joeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{i5OVU{Lz5{Nke4PVU2OzxxYU6=
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BA/F3	M1K2T2Z2dmO2aX;uJIF{e2G7		Ml\EO\|IhcHK\|	NUPwVG1nUW6qaXLpeIlwdiCxZjDLbZQh\XixbjCxNUBl\WyndHnvckApPTV5IITvJFU2QCC{ZYPp[JVmeyliYX7kJHY3PTSDIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCCpcn;3eIghcW6ldXLheIVlKG[xcjC3NkBpenNiYomgUXRUKGG\|c3H5MEBIUTVyIE2gNE4{QTJizszNMi=>	NUjaPGp3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BA/F3	NF7MfllCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=	NIrCelM2KHSxIEGwJJVO	MX60PEBpenN?	MnXYRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDtc5V{\SCEQT;GN{Bk\WyuczDlfJBz\XO\|aX7nJG5RVS2jYnygZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZZQhPSC2bzCxNEB2VSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5\|OUOg{txONg>?	MkW1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2MUW4OlMoRjF4NEG1PFY{RC:jPh?=
K562	MVzGeY5kfGmxbjDhd5NigQ>?			MnLWTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOg[5Jwf3SqIIXzbY5oKE2WVDDhd5NigSxiSVO1NEA:KDBwNDFOwG0v	M2PNWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2NUWyO\|YxLz5zNEW1Nlc3ODxxYU6=
BAF3	MlrBSpVv[3Srb36gZZN{[Xl?		M2XDU\|czKGi{cx?=	MmLtTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT\|gh[XO\|YYmsJGdKPTBiPTCwMlQh\|ryPLh?=	NEHTVJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
BA/F3	MVjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NUfOSWM{PzJiaILz	M1[5S2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW\|c3nu[{BD[3JvQXLsJG0{PTGWIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSByLkSyOEDPxE1w	NXz0S4RFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
KCL22	MlnaRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MonpOFghcHK\|	MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEuFTEKyJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCFZXzsMXRqfGW{LVfsc{BtfW2rbnXzZ4VvfCClZXzsJJZq[WKrbHn0fUBie3OjeTygS2k2OCB;IECuOFMh\|ryPLh?=	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzMUG1PUc,OjdyMUGxOVk9N2F-
Ba/F3	MoX4SpVv[3Srb36gZZN{[Xl?		MWq0PEBpenN?	NHnaUY9KdmirYnn0bY9vKG:oIFLDVk1CSkxzIGGyOVJJKG23dHHueEApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCvb4Xz[UBD[S:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEKFUj3BRmwyNW2nZHnheIVlKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkA1QCCqcoOgZpkhSnKrdHXMbYdpfCCudXPp[oVz[XOnIHHzd4F6NCCJSUWwJF0hOC52NUWg{txONg>?	NYfMfJR1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxN\|c6QDFpPkOwNVM4QThzPD;hQi=>
Sf9	NWDKPYcyTnWwY4Tpc44h[XO\|YYm=			MXjJcohq[mm2aX;uJI9nKGi3bXHuJGFjdCCtaX7hd4Uh\XiycnXzd4VlKGmwIGPmPUBk\WyuczygTWM2OCB;IECuOFch\|ryPLh?=	M3LxPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{e2OlgxLz5zN{O3OlY5ODxxYU6=
K562	M{fHRmN6fG:2b4jpZ4l1gSCjc4PhfS=>		MVK0PEBpenN?	MoH0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC52NzFOwG0v	M3r4NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|N{O1PFI3Lz5{M{ezOVgzPjxxYU6=
K562	M2rjRWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M3;z[VQ5KGi{cx?=	MlX0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkS3JO69VS5?	NWXLTIoyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3O\|g4PjZpPkK1O\|c5PzZ4PD;hQi=>
K562	MmDYSpVv[3Srb36gZZN{[Xl?			M2[2WmlvcGmkaYTpc44hd2ZiQlPSMWFDVDFiYYX0c5Bpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDLOVYzKGOnbHzzMEBKSzVyIE2gNE41PzNizszNMi=>	MnTzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N\|goRjJyOEG3OVM5RC:jPh?=
insect cells	MUjGeY5kfGmxbjDhd5NigQ>?		MY[zNEBucW6\|	MYjJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEGETEGgSVI2PUtibYX0ZY51KGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMh[W[2ZYKgN\|AhdWmwczDifUBHWkWWIHHzd4F6NCCLQ{WwJF0hOC52OEW4JO69VS5?	M2\3RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{CxO\|A{Lz5{M{OwNVcxOzxxYU6=
Sf9	MkPoSpVv[3Srb36gZZN{[Xl?			NWDOdWR2SmmwZHnu[{Bi\m[rbnn0fUB1dyCqdX3hckBz\W2xdHWgd4l1\SCxZjDOMZRmem2rbnHsJIhmgGGqaYP0bYRqdmVvdHHn[4VlKEGETEKg[ZhxemW\|c3XkJIlvKFS{aXPoc5BtfXOrYTDubUBqdm[nY4Tl[EBU\jliY3XscJMh[nliaYPveIhmem2jbDD0bZRz[XSrb36gZ4Ftd3KrbXX0dolkKGG\|c3H5MEBM\CB;IECuOUDPxE1w	NUHjR\|Z1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0NVc{PDNpPkKxOFE4OzR\|PD;hQi=>
primary leukemia cells	MmO4R5l1d3SxeHnjbZR6KGG\|c3H5		NH75R4g4OiCqcoO=	NVrMOI83S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4heHKrbXHyfUBt\XWtZX3pZUBk\WyuczDpd49t[XSnZDDmdo9uKGGldYTlJI16\WyxaXSgcIV2c2WvaXGgdIF1cWWwdDDlfJBz\XO\|aX7nJGZNXDNvREizOXkhdXW2YYTpc44h[XO\|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JIx2[2moZYLhd4Uh[XO\|YYmsJGlEPTBiPTCwMlUh\|ryPLh?=	NFXlSJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNVIxOSd-MkKyNlEzODF:L3G+
BA/F3	NUjndYI6TnWwY4Tpc44h[XO\|YYm=		MWW3NkBpenN?	MWrJcohq[mm2aX;uJI9nKFSHTD3MR2shMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO\|YYmsJGdKPTBiPTCwMlUh\|ryPLh?=	NUj0bmV[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3PFk2PTNpPkK2O\|g6PTV\|PD;hQi=>
K562	NIrBe4pCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			M1vHT2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczygTWM2OCB;IECuOUDPxE1w	NUC3WFZYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzOVI1QDNpPkKzN\|UzPDh\|PD;hQi=>
K562	MkXiR5l1d3SxeHnjbZR6KGG\|c3H5		NX72WYpXPzJiaILz	NUK2OHNuS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA4OiCqcoOgZpkh[2GuY3Xpck1CVSCjc4PhfUwhUUN3MDC9JFAvPSEQvF2u	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl6MUWzNkc,OjN7OEG1N\|I9N2F-
K562	MoizR5l1d3SxeHnjbZR6KGG\|c3H5		Mn7ZO\|IhcHK\|	Ml65R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bi\nSncjC3NkBpenNidYPpcochS2GuY3XpckBCVSCkeTDmcJVwemW\|Y3XuZ4Uh[XO\|YYmsJGlEPTBiPTCwMlUh\|ryPLh?=	MojiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5NUe2NFMoRjJ3N{W3OlA{RC:jPh?=
K562	MXnDfZRwfG:6aXPpeJkh[XO\|YYm=			MUjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzMEBKSzVyIE2gNE42KM7:TT6=	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF6OU[3OEc,OjdzOEm2O\|Q9N2F-
BA/F3	MnPqR5l1d3SxeHnjbZR6KGG\|c3H5		M2P0WVczKGi{cx?=	NGD5XI1EgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIIfpcIQhfHmyZTDCR3IuSUKOIHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDDR2suQCCjc4PhfUwhUUN3MDC9JFAvPSEQvF2u	Mn:zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|MEG3NFMoRjJ\|M{CxO\|A{RC:jPh?=
K562	M2PqR2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		NGqxTGk1QCCqcoO=	MlTNRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkWg{txONg>?	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl\|MkC3NUc,OjN7M{KwO\|E9N2F-
Sf9	NUnubXRmTnWwY4Tpc44h[XO\|YYm=			M4HI[XRRZ1SUQV7TVG9TXEWUOjDpcohq[mm2aX;uJI9nKEGWUHHz[UBi[3Srdnn0fUBqdiCEQ2LQMYV5eHKnc4PpcochW2Z7IHPlcIx{NCCLQ{WwJF0hOC53IN88UU4>	M2myUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MUW1PFQyLz5zNUG1OVg1OTxxYU6=
K562	MYPDfZRwfG:6aXPpeJkh[XO\|YYm=		MlXHO\|IhcHK\|	NVywcVdkS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC53MTFOwG0v	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjhzNEi5NEc,OjZ6MUS4PVA9N2F-
K562	MVvDfZRwfG:6aXPpeJkh[XO\|YYm=		NHHJW2E1QCCqcoO=	MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCwMlU{KM7:TT6=	M3v4dFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{C3PFQ3Lz5{NkewO\|g1PjxxYU6=
K562	NW\Se25GSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MnXpOFghcHK\|	M3PkfmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMD61N{DPxE1w	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV{NUizPEc,Ojh3MkW4N\|g9N2F-
BA/F3	Ml72SpVv[3Srb36gZZN{[Xl?		MoTzO\|IhcHK\|	MWXJcohq[mm2aX;uJI9nKEurdDDlfI9vKDFzIHTlcIV1cW:wIDi1OVchfG9iNUW4JJJme2mmdXXzLUBidmRiREixOmghdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkWzOUDPxE1w	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BA/F3	NW\oSHJvTnWwY4Tpc44h[XO\|YYm=		NHO4TXI4OiCqcoO=	NXTZbHNFUW6qaXLpeIlwdiCxZjDQSGdHWmGucHjhJHY2PjGGL1S4OFJXKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMD61Olch\|ryPLh?=	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
K562	NH\YUXBEgXSxdH;4bYNqfHliYYPzZZk>		MojyOFghcHK\|	MYjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCwMlU5KM7:TT6=	NV;3fmtORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyPVU{QDBpPkKxNlk2OzhyPD;hQi=>
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BA/F3	Mo\BSpVv[3Srb36gZZN{[Xl?		NFfrVHM4OiCqcoO=	NWHFZlloUW6qaXLpeIlwdiCxZjDCR3IwSUKOIICyNVAuVTN3MWSgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUy16IHHzd4F6NCCJSUWwJF0hOC54MkWg{txONg>?	MkD3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm1OVMoRjJ4N{i5OVU{RC:jPh?=
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EW-18	MXrHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NX[1WJNOUW6qaXLpeIlwdiCxZjDoeY1idiCHVz2xPEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDhwNEO5OUDPxE1w	MojyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-STAT3 / STAT3 / p-STAT5 / STAT5; PubMed: 18981115 J Immunol For phospho-STAT3 and Phospho-STAT5 detection, cells were then activated for 6 hrs with anti-CD3 and anti-CD28 Ab. Equivalent amounts of protein from cell lysates were separated by SDS-PAGE and western blot analysis was then performed using anti-phospho S䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖 p-ZAP70 / ZAP70 / p-LAT / LAT; PubMed: 18981115 J Immunol For the analysis of imatinib interference with early TCR signaling events, cells were activated for 5 min with anti-CD3 and anti-CD28 Abs and blots were probed with anti-phospho ZAP70, anti-ZAP70, anti-phospho LAT or anti-LAT antibodies. Untreated, non-ac䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 	18981115
Immunofluorescence	RelB; PubMed: 20371728 Mol Cancer Ther Nuclear proteins were extracted from the untreated and treated cells and nuclear levels of RelA and RelB were confirmed by immunocytochemistry Cortactin / F-actin; PubMed: 20937825 J Biol Chem NIH3T3-SrcY527F cells were treated with DMSO or with 10 μm STI571 for 16 h, fixed and co-stained for cortactin (red, left panels) and F-actin (green, middle panels). Merged fields (right panels) demonstrate co-localization between cortactin and F-actin at䲧疝Ỵ疞㧀疜	20371728 20937825
Growth inhibition assay	Cell viability ; PubMed: 28435223 Drug Des Devel Ther (C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. 䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺	28435223

体内研究

Imatinib抑制从新鲜的人小细胞肺癌外科样品来源的SCLC6，SCLC61和SCLC108异种移植肿瘤，抑制率分别是80％，40％和78％，且对SCLC74生长长无显著抑制。^[5] 在高脂肪喂养的ApoE（-/-）小鼠中，通过管饲法给药10 mg/kg，20 mg/kg和40 mg/kg Imatinib，和对照组相比高脂诱导的脂质染色区域减少了30％，27％和35％，并且颈动脉脂质积聚得到抑制。^[6]

激酶实验：^[1]	- 合并 PDGF受体激酶活性 : PDGF受体是由BALB / c3T3细胞提取物免疫共沉淀所得，通过兔抗PDGF受体冰上处理2小时所得。蛋白A-琼脂糖珠被用于收集抗原-抗体复合物。免疫沉淀物用TNET（50 mM Tris，pH 7.5，140 mM氯化钠，5mM的EDTA，1％的Triton X-100）洗涤两次，用TNE（50 mM Tris，pH 7.5，140 mM EDTA）洗涤一次，并用激酶缓冲液（20 mM的Tris，pH 7.5, 10 mM氯化镁）洗涤一次。用PDGF（50 ng/mL）在4℃下刺激10分钟后，不同浓度的药物加入到反应混合物中。PDGF受体激酶活性是通过温浴10 μCi [³³P]-ATP和l μM ATP 10分钟来确定。免疫复合物经SDS-PAGE上的7.5％凝胶上分离。
细胞实验：^[3]	- 合并 Cell lines: BON-1 和 NCI-H727细胞 Concentrations: 约100 μM Incubation Time: 48小时 Method: BON-1细胞和NCI-H727细胞接种到平底96孔板中三个复孔，并在含10％胎牛血清的DMEM或RPMI1640完全培养基中贴壁过夜，然后更换为血清培养基（阴性对照）或含不同浓度梯度Imatinib的无血清培养基。48小时（对照培养物没有达到汇合）后，代谢活性细胞的数量是由3-（4,5-二甲基吡啶-2-基）-2,5-二苯基溴化测定，由帕卡德光谱酶标仪测定540nm处吸光度。生长抑制通过以下公式计算：抑制率=(1 − a / b) × 100%，其中a和b分别是治疗组和对照组的吸光度值。 (Only for Reference)
动物实验：^[5]	- 合并 Animal Models: SCLC6, SCLC61, SCLC 74 and SCLC108 小细胞肺癌注入瑞士小鼠 (nu/nu, 雌性）。 Dosages: 70或100 mg/kg Administration: 腹腔注射 (Only for Reference)

参考文献

- 合并

溶解度 (25°C)

体外	DMSO	118 mg/mL (200.09 mM)
	Water	118 mg/mL (200.09 mM)
	Ethanol	Insoluble

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Imatinib (STI571) Mesylate SDF

分子量	589.71
化学式	C₂₉H₃₁N₇O.CH₄SO₃
CAS号	220127-57-1
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	Gleevec, Glivec, CGP-57148B

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-05-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02687425	Unknown status	Drug: Pioglitazone\|Drug: imatinib mesylate	Leukemia Myelogenous Chronic BCR-ABL Positive	Meng Li\|Tongji Hospital	February 2016	Phase 2
NCT02303899	Completed	Drug: Gemcitabine\|Drug: Imatinib mesylate	Mesothelioma Malignant	Istituto Clinico Humanitas	November 2014	Phase 2
NCT01898377	Terminated	Drug: Imatinib mesylate Mycophenolate mofetil	Chronic Graft-versus-host Disease	Seoul National University Hospital	August 2013	Phase 2
NCT02891395	Completed	Drug: Imatinib Mesylate and Nilotinib	Graft Versus Host Disease	University Hospital Lille\|Novartis	December 24 2012	Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

选择性强的Bcr-Abl抑制剂

Nilotinib (AMN-107) : Bcr-Abl-selective, IC50<30 nM.
活性最高的Bcr-Abl抑制剂

GZD824 : Bcr-Abl(WT), IC50=0.34 nM; Bcr-Abl(T315I), IC50=0.68 nM.
FDA批准的Bcr-Abl抑制剂

Dasatinib : Approved by FDA for CML and Ph+ ALL.
最新的Bcr-Abl抑制剂

GZD824 : Orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

研究领域

产品类型

定制您的化合物库

Imatinib (STI571) Mesylate

客户使用Selleck生产的Imatinib (STI571) Mesylate发表文献167篇：

产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Imatinib (STI571) Mesylate SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-05-17)

技术支持

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

相关Bcr-Abl产品