Imatinib (STI571) Mesylate

For research use only. Not for use in humans.

目录号：S1026 别名： Gleevec, Glivec, CGP-57148B 中文名称：甲磺酸伊马替尼

Imatinib (STI571) Mesylate Chemical Structure

CAS No. 220127-57-1

Imatinib Mesylate (STI571, CGP-57148B)是一种口服生物有效的Imatinib甲磺酸盐，是一种多靶点抑制剂，作用于v-Abl，c-Kit和PDGFR，在无细胞和细胞试验中，IC50分别为0.6 μM，0.1 μM 和0.1 μM。Imatinib Mesylate (STI571) 可诱导自噬。

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10mM (1mL in DMSO)	RMB 1567.38	现货
100mg	RMB 780.01	现货
250mg	RMB 1603.82	现货
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客户使用Selleck生产的Imatinib (STI571) Mesylate发表文献159篇：

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Nat Commun, 2017, 1;8(1):1232

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产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

产品描述

靶点

PDGFR ^[1] (Cell-free assay)	c-Kit ^[2] (M-07e cells)	v-Abl ^[1] (Cell-free assay)
100 nM	100 nM	600 nM

体外研究

抑制酪氨酸和丝氨酸/苏氨酸蛋白激酶的体外测定法显示Imatinib有效抑制V-Abl酪氨酸激酶和PDGFR，IC50分别为0.6 μM和0.1 μM。^[1] Imatinib抑制SLF-依赖性激活的野生型的c-kit激酶活性，IC 50约为0.1 μM，这类似抑制PDGFR所需的浓度。^[2] Imatinib表现出对人支气管类癌细胞系NCI-H727和人胰腺类癌细胞系BON-1的抑制作用，IC50分别为32.4 μM和32.8 μM。 ^[3] 最近的一项研究显示，Imatinib通过下调hERG1 K(+)通道发挥在慢性粒细胞白血病的抗白血病作用，hERG1 K(+)通道在白血病细胞中高表达并表现有利于白血病出现。^[4]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
GIST882	Mnn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MUW5OkBp	M3LYO2lEPTB;MT63JO69VQ>?	MkDKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MECyNVIoRjJ2OUCwNlEzRC:jPh?=
K562	MXjDfZRwfG:6aXPpeJkhSXO\|YYm=		MWiyOEBp	NUHhdWpmUUN3ME2wMlIyKM7:TR?=	M1X3RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MECwNlA4Lz5{MkCwNFIxPzxxYU6=
MCF-7	NGTvNIREgXSxdH;4bYNqfHliQYPzZZk>		M2C2eVI1KGh?	NHjIZnFKSzVyPUCuPFMh\|ryP	NVvJVoI4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNFAzODdpPkKyNFAxOjB5PD;hQi=>
MDA-MB-23	MmfLR5l1d3SxeHnjbZR6KEG\|c3H5		NXjTbpBXOjRiaB?=	MYjJR\|UxRTFwODFOwG0>	NEXiWGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkCwNFIxPyd-MkKwNFAzODd:L3G+
K562r	MmjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M2rkWmlEPTB;MUFCpO69VQ>?	NV;4S2s5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5N\|k1OThpPkK0PVM6PDF6PD;hQi=>
K562	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NX\Mc5Y{TUN3ME2wMlA6KM7:TR?=	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjZ5OESxOEc,OTZ4N{i0NVQ9N2F-
MCF-7	NFPzfYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHrhVYUyOCEQvF2=	NGTqW\|A1QCCq	NIjse5VjdG:la4OgZ4VtdCCycn;sbYZmemG2aX;uJIlv[3KnYYPlJIlv\HWlZXSgZpkhSkp\|Wh?=	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ5NECzOEc,OjV{N{SwN\|Q9N2F-
K-562	NI\GbGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NWnhSmlXUUN3ME2xJO69VQ>?	NWXjdlVZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyN\|k3PjJpPkK1NlM6PjZ{PD;hQi=>
K562	NIfjU5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NHvGRoFKSzVyPUCuOeKh\|ryP	M1H3ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUO5OFE5Lz5{NEmzPVQyQDxxYU6=
PC3	NULGV4dDSXCxcITvd4l{KEG\|c3H5	NYXnPWx{OjEkgJpOwG0>	MoHsOFgwPzJiaB?=	MlrobY5kemWjc3XzJINmdGxic4Xyeol3[Wx?	NUjwTFBKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PFY3PTZpPkK1O\|g3PjV4PD;hQi=>
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GIST882	MYHGeY5kfGmxbjDhd5NigQ>?			NFnZ[HRKdmirYnn0bY9vKG:oIFvJWEBMPjR{RTDteZRidnRiYYX0c5Bpd3OyaH;yfYxifGmxbjCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBpfW2jbjDHTXNVQDh{IHPlcIx{KGK7IFXMTXNCNCCLQ{WwJF0hOC5yOUeg{txONg>?	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzMUe3NUc,OjN4MUG3O\|E9N2F-
insect	NH7NbZBHfW6ldHnvckBie3OjeR?=		NUXQUW9JOzBibXnudy=>	MoLHTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCC5aXzkJJR6eGViQVLMNUBmgHC{ZYPz[YQhcW5iaX7z[YN1KGOnbHzzJIFnfGW{IEOwJI1qdnNiYomgSnJGXCCjc4PhfUwhUUN3MDC9JFAvODl6MjFOwG0v	NEL6UWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
K562	NIrDXFVEgXSxdH;4bYNqfHliYYPzZZk>		NInaNJM4OiCqcoO=	Mki2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSByLkGg{txONg>?	NUnNZ3hZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
primary leukemia cells	MYnDfZRwfG:6aXPpeJkh[XO\|YYm=		NWrtSIhiPzJiaILz	MojHR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdJJqdWG{eTDs[ZVs\W2rYTDj[YxteyCrc3;sZZRm\CCocn;tJIFkfXSnIH35[YxwcWRibHX1b4VucWFicHH0bYVvfCCneIDy[ZN{cW6pIIfpcIQhfHmyZTDGUHQ{KGG\|c3Xzd4VlKGG\|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBtfWOrZnXyZZNmKGG\|c3H5MEBKSzVyIE2gNE4yKM7:TT6=	Ml;lQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MkGyNFEoRjJ{MkKxNlAyRC:jPh?=
BV173	M1fl[WFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NXroXmtmPDhiaILz	M3yxcGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQm[xO\|Mh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IFPlcIwuXGm2ZYKtS4xwKGy3bXnu[ZNk\W62IHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBIUTVyIE2gNE4yKM7:TT6=	NGi2cIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxNVE2QSd-MkewNVEyPTl:L3G+
BAF3	NV\PN\|BGTnWwY4Tpc44h[XO\|YYm=		NWfXZ4RlPzJiaILz	M3jrSmlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHPLTXQhVDV4N2CgcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIx1cXSncj3ncI8wS0ONODDhd5NigSxiR1m1NEA:KDBwMTFOwG0v	M4DoZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O\|A2Lz5{N{C3O\|cxPTxxYU6=
K562	NWPkUWhIS3m2b4TvfIlkcXS7IHHzd4F6		M1O0U\|I1KGi{cx?=	M4foVmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgNlQhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOSEQvF2u	MmLoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ4M{K5N\|UoRjJ{NkOyPVM2RC:jPh?=
BA/F3	NV[3NFJqTnWwY4Tpc44h[XO\|YYm=		MoTzO\|IhcHK\|	M1XvdmlvcGmkaYTpc44hd2ZiVFXMMYZ2e2WmIGDES2ZT[mW2YTCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJCN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDDndo94fGhiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCJSUWwJF0hOC5zMEKg{txONg>?	MmXKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BAF3	NHXmXmxHfW6ldHnvckBie3OjeR?=		NWe4[mFqPzJiaILz	M1vSVWlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHOtT2lVKEx3N{\QJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBDSUZ\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHfyc5d1cCCrbnjpZol1cW:wIH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFS{igZZN{[XluIFfJOVAhRSByLkGwNkDPxE1w	MnrpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
GIST882	MWHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			NW\Ec4lvSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHTXNVQDh{IHPlcIx{NCCLQ{WwJF0hOC5zMEig{txONg>?	NUPnOoZ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
GIST882	NEHG[IpHfW6ldHnvckBie3OjeR?=			NEHDeVBKdmirYnn0bY9vKG:oIFvJWEBMPjR{RTDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gbJVu[W5iR1nTWFg5OiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KEGWUD3k[ZBt\XSrb36gZZN{[XluIFnDOVAhRSByLkGwPEDPxE1w	MmjJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUG3O\|EoRjJ\|NkGxO\|cyRC:jPh?=
K562	M{D2RWN6fG:2b4jpZ4l1gSCjc4PhfS=>			NVeyfopPS3m2b4TvfIlkKGWoZnXjeEBqdiCNNU[yJINmdGy\|LDDJR\|UxKD1iMD6xNUDPxE1w	NGrYdoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkm1NVEyOyd-MUK5OVEyOTN:L3G+
KU812	NVLUTIZQSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NXn0[2FMPzJiaILz	NHrkfpJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFvVPFEzKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG\|c3H5MEBIUTVyIE2gNE4yOSEQvF2u	M1GycFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
BA/F3	NVLDfG1jSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NXL0UoRMPzJiaILz	NESye\|dCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LVHicEBJOzl4UDDteZRidnRiYX\0[ZIhPzJiaILzJIJ6KEOFSz24JIF{e2G7LDDJR\|UxKD1iMD6xNUDPxE1w	M{Sz[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
BAF3	Ml;NSpVv[3Srb36gZZN{[Xl?		M2fjXVczKGi{cx?=	M4f0PWlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIFPTSlFTKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44hdWWjc4Xy[YQh[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMQCCjc4PhfUwhT0l3MDC9JFAvOTFizszNMi=>	M1f3O\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
32D	M2DDbmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NYDYTlVLPDhiaILz	MW\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKDN{RDDj[YxteyC2cnHud4Zm[3SnZDD3bZRpKHB{MUCgZ4VtdHNiZYjwdoV{e2mwZzDCZ5Iu[WKuIHHzd4V{e2WmIHHzJJBzd2yrZnXyZZRqd25iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMUGyJO69VS5?	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjRzNUi2N{c,OTZ2MUW4OlM9N2F-
insect cells	NFTBbVdHfW6ldHnvckBie3OjeR?=		NYrabGhDOzBibXnudy=>	MlntTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCDQlyxJG0{PTGWIH31eIFvfCCneIDy[ZN{\WRiaX6gbY5{\WO2IHPlcIx{KGGodHXyJFMxKG2rboOgZpkhTlKHVDDhd5NigSxiSVO1NEA:KDBwMUG0N{DPxE1w	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN\|MEG3NFM9N2F-
insect cells	NEDYd4RHfW6ldHnvckBie3OjeR?=		NWSx[G5vOzBibXnudy=>	NX3OXGhrUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDBRmwyKFF{NULIJI12fGGwdDDlfJBz\XO\|ZXSgbY4hcW6\|ZXP0JINmdGy\|IHHmeIVzKDNyIH3pcpMh[nliRmLFWEBie3OjeTygTWM2OCB;IECuNVE2KM7:TT6=	NEP4V2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
K562	Mnm4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M{TCNFczKGi{cx?=	NW\rRmtkSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBDS1JvQVLMJIRmeGWwZHXueEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkh[2WubITpeIVzNWeubz;DR2s5KGG\|c3H5MEBIUTVyIE2gNE4yOiEQvF2u	NFvnTVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
BA/F3	M3XN[2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		M4e5WVczKGi{cx?=	NF7hO5lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LVHicEBOOjR2VjDteZRidnRiYX\0[ZIhPzJiaILzJIJ6KEOFSz24JIF{e2G7LDDJR\|UxKD1iMD6xNlkh\|ryPLh?=	M4W1XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
K562	M2LWNmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NVvE[W02PzJiaILz	M3O2VGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1utPEBie3OjeTygS2k2OCB;IECuNVQh\|ryPLh?=	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
HEK293	MY\GeY5kfGmxbjDhd5NigQ>?			NWTEUpNFUW6qaXLpeIlwdiCxZjDheZRweGixc4Doc5J6dGG2aX;uJI9nKESGUkKg[ZhxemW\|c3XkJIlvKEiHS{K5N{Bk\WyuczDifUBGVEmVQTygTWM2OCB;IECuNVQyKM7:TT6=	Mnq4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N\|goRjJyOEG3OVM5RC:jPh?=
K562	M{G4fWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M{jlO\|czKGi{cx?=	Ml[5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHygeIl1\XJvZ3zvJIF{e2G7LDDHTVUxKD1iMD6xOFch\|ryPLh?=	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV2MU[5OUc,Ojh3NEG2PVU9N2F-
BAF3	MnHLSpVv[3Srb36gZZN{[Xl?		M2KwbVczKGi{cx?=	M{S4OWlvcGmkaYTpc44hd2ZiVFXMMYZ2e2WmIHPLTXQhSTh{OWCgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3ncI8h[XO\|YYmsJGdKPTBiPTCwMlE1QDJizszNMi=>	M4LiZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
Ba/F3	M1rBVmZ2dmO2aX;uJIF{e2G7		MVO0PEBpenN?	NFziO4tKdmirYnn0bY9vKG:oIFLDVk1CSkxzIFWzOVVIKG23dHHueEApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCvb4Xz[UBD[S:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEKFUj3BRmwyNW2nZHnheIVlKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkA1QCCqcoOgZpkhSnKrdHXMbYdpfCCudXPp[oVz[XOnIHHzd4F6NCCJSUWwJF0hOC5zNEmg{txONg>?	Mo[2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzM{e5PFEoRjNyMUO3PVgyRC:jPh?=
KU812	M{[wfmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NHz4XIw4OiCqcoO=	MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEuXOEGyJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFSz24JIF{e2G7LDDHTVUxKD1iMD6xOkDPxE1w	NVvjdmVGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3PFk2PTNpPkK2O\|g6PTV\|PD;hQi=>
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K562	MYTDfZRwfG:6aXPpeJkh[XO\|YYm=		MUe3NkBpenN?	Ml;YR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRUKGG\|c3H5MEBIUTVyIE2gNE4{QSEQvF2u	NGrmPW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmzNlMyOyd-MkK5N\|I{OTN:L3G+
BA/F3	MV;GeY5kfGmxbjDhd5NigQ>?		MVW3NkBpenN?	MWLJcohq[mm2aX;uJI9nKEurdDDlfI9vKDFzIHTlcIV1cW:wIDi1OVchfG9iNUW4JJJme2mmdXXzLUBidmRiVk[1OGEhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkO5NkDPxE1w	MkjwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BA/F3	M{\ncmFvfGmycn;sbYZmemG2aY\lJIF{e2G7	M4f2UVUhfG9iMUCgeW0>	M2S3SFQ5KGi{cx?=	MkXGRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDtc5V{\SCEQT;GN{Bk\WyuczDlfJBz\XO\|aX7nJG5RVS2jYnygZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZZQhPSC2bzCxNEB2VSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5\|OUOg{txONg>?	Mlr3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2MUW4OlMoRjF4NEG1PFY{RC:jPh?=
K562	M{nx[2Z2dmO2aX;uJIF{e2G7			MX3Jcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDndo94fGhidYPpcochVVSWIHHzd4F6NCCLQ{WwJF0hOC52IN88UU4>	NEHXTIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEW1Nlc3OCd-MUS1OVI4PjB:L3G+
BAF3	MoXYSpVv[3Srb36gZZN{[Xl?		MoS0O\|IhcHK\|	NXnR[m9QUW6qaXLpeIlwdiCxZjDU[Ywu\nW\|ZXSgZ2tKXCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvM2NEUzhiYYPzZZktKEeLNUCgQUAxNjRizszNMi=>	Ml\6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
BA/F3	NHTIWXNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NYTQU4FJPzJiaILz	NUS1VJFNSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhVTN3MWSgcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IECuOFI1KM7:TT6=	M2XYflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
KCL22	Ml7jRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MWO0PEBpenN?	MmH1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNQ1yyNkBk\WyuczDh[pRmeiB2ODDodpMh[nliQ3XscE1VcXSncj3HcI8hdHWvaX7ld4NmdnRiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGdKPTBiPTCwMlQ{KM7:TT6=	NWDQT2tmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVEyPTlpPkK3NFEyOTV7PD;hQi=>
Ba/F3	NYDNd\|VXTnWwY4Tpc44h[XO\|YYm=		MUS0PEBpenN?	M1PyUWlvcGmkaYTpc44hd2ZiQlPSMWFDVDFiUUK1NmghdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJiN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhSkOULVHCUFEudWWmaXH0[YQh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBDemm2ZVzp[4h1KGy3Y3nm[ZJie2ViYYPzZZktKEeLNUCgQUAxNjR3NTFOwG0v	M4nFTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUO3PVgyLz5\|MEGzO\|k5OTxxYU6=
Sf9	MnG1SpVv[3Srb36gZZN{[Xl?			MWDJcohq[mm2aX;uJI9nKGi3bXHuJGFjdCCtaX7hd4Uh\XiycnXzd4VlKGmwIGPmPUBk\WyuczygTWM2OCB;IECuOFch\|ryPLh?=	NEDHUXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O3OlY5OCd-MUezO\|Y3QDB:L3G+
K562	NHPYWmpEgXSxdH;4bYNqfHliYYPzZZk>		NWW3XoVkPDhiaILz	NUL6NYFCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMD60O{DPxE1w	NWr0UohURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3N\|U5OjZpPkKzO\|M2QDJ4PD;hQi=>
K562	M1TRd2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		MUm0PEBpenN?	NHvyWoRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuOFch\|ryPLh?=	MmXBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5N{i3OlYoRjJ3N{e4O\|Y3RC:jPh?=
K562	NXLPR2ZETnWwY4Tpc44h[XO\|YYm=			NVj4[ZJ1UW6qaXLpeIlwdiCxZjDCR3IuSUKOMTDheZRweGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJGs2PjJiY3XscJMtKEmFNUCgQUAxNjR5MzFOwG0v	M{LYdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEG3OVM5Lz5{MEixO\|U{QDxxYU6=
insect cells	MVrGeY5kfGmxbjDhd5NigQ>?		NFXac2M{OCCvaX7z	NYryWG9GUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDBRmwyKEV{NUXLJI12fGGwdDDlfJBz\XO\|ZXSgbY4hcW6\|ZXP0JINmdGy\|IHHmeIVzKDNyIH3pcpMh[nliRmLFWEBie3OjeTygTWM2OCB;IECuOFg2QCEQvF2u	Mkj3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|MEG3NFMoRjJ\|M{CxO\|A{RC:jPh?=
Sf9	MVPGeY5kfGmxbjDhd5NigQ>?			MXzCbY5lcW6pIHHm[olvcXS7IITvJIh2dWGwIILlcY91\SC\|aYTlJI9nKE5vdHXycYlv[WxiaHX4ZYhqe3SrZHnu[U11[WepZXSgRWJNOiCneIDy[ZN{\WRiaX6gWJJq[2ixcHz1d4liKG6rIHnu[oVkfGWmIGPmPUBk\WyuczDifUBqe2:2aHXycYFtKHSrdILheIlwdiClYXzvdolu\XS{aXOgZZN{[XluIFvkJF0hOC53IN88UU4>	NFP4e5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUSxO\|M1Oyd-MkG0NVc{PDN:L3G+
primary leukemia cells	MXfDfZRwfG:6aXPpeJkh[XO\|YYm=		M{CydVczKGi{cx?=	NFLPd3FEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBxemmvYYL5JIxmfWunbXnhJINmdGy\|IHnzc4xifGWmIH\yc40h[WO3dHWgcZlmdG:rZDDs[ZVs\W2rYTDwZZRq\W62IHX4dJJme3OrbnegSmxVOy2GOEO1XUBufXSjdHnvckBie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgcJVkcW[ncnHz[UBie3OjeTygTWM2OCB;IECuOUDPxE1w	NFuwN409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNVIxOSd-MkKyNlEzODF:L3G+
BA/F3	NEH2em1HfW6ldHnvckBie3OjeR?=		NFPE[Wo4OiCqcoO=	NY\KO2g6UW6qaXLpeIlwdiCxZjDUSWwuVEONIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUy16IHHzd4F6NCCJSUWwJF0hOC53IN88UU4>	NGD2c\|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
K562	NF7udFNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			MXXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNuIFnDOVAhRSByLkWg{txONg>?	M{PoWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{WyOFg{Lz5{M{O1NlQ5OzxxYU6=
K562	MXfDfZRwfG:6aXPpeJkh[XO\|YYm=		MXe3NkBpenN?	NUPm[FhXS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA4OiCqcoOgZpkh[2GuY3Xpck1CVSCjc4PhfUwhUUN3MDC9JFAvPSEQvF2u	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl6MUWzNkc,OjN7OEG1N\|I9N2F-
K562	MX7DfZRwfG:6aXPpeJkh[XO\|YYm=		MoD0O\|IhcHK\|	M3[1bmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgO\|IhcHK\|IIXzbY5oKEOjbHPlbY4hSU1iYomg[ox2d3Knc3PlcoNmKGG\|c3H5MEBKSzVyIE2gNE42KM7:TT6=	NFK5OWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe1O\|YxOyd-MkW3OVc3ODN:L3G+
K562	M2m5b2N6fG:2b4jpZ4l1gSCjc4PhfS=>			MlLER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{whUUN3MDC9JFAvPSEQvF2u	M1rZdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUi5Olc1Lz5{N{G4PVY4PDxxYU6=
BA/F3	MWPDfZRwfG:6aXPpeJkh[XO\|YYm=		MlmxO\|IhcHK\|	MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBud3W\|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKHerbHSgeJlx\SCEQ2KtRWJNKGG\|c3Xzd4VlKGG\|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IECuOUDPxE1w	NVi4VpRpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
K562	MmjkRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NFH2d3A1QCCqcoO=	M3\Bb2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMD61JO69VS5?	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl\|MkC3NUc,OjN7M{KwO\|E9N2F-
Sf9	Mn\HSpVv[3Srb36gZZN{[Xl?			MljCWHBgXFKDTmPQU3JVTVJ8IHnubIljcXSrb36gc4YhSVSSYYPlJIFkfGm4aYT5JIlvKEKFUmCt[ZhxemW\|c3nu[{BU\jliY3XscJMtKEmFNUCgQUAxNjVizszNMi=>	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTF3NUi0NUc,OTVzNUW4OFE9N2F-
K562	NHHnWpNEgXSxdH;4bYNqfHliYYPzZZk>		MVy3NkBpenN?	MoDNR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNE42OSEQvF2u	NFTsW2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkixOFg6OCd-Mk[4NVQ5QTB:L3G+
K562	NHHuS4REgXSxdH;4bYNqfHliYYPzZZk>		NVLEWmNRPDhiaILz	MUjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCwMlU{KM7:TT6=	MknaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5MEe4OFYoRjJ4N{C3PFQ3RC:jPh?=
K562	NXfQXYVXSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NVjMNpFZPDhiaILz	MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwNUOg{txONg>?	MlHlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3MkW4N\|goRjJ6NUK1PFM5RC:jPh?=
BA/F3	MUfGeY5kfGmxbjDhd5NigQ>?		Ml;wO\|IhcHK\|	M3HBXGlvcGmkaYTpc44hd2ZiS3n0JIV5d25iMUGg[IVt\XSrb36gLFU2PyC2bzC1OVghemW\|aXT1[ZMqKGGwZDDEPFE3UCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OCB;IECuOVM2KM7:TT6=	NX;oSIpkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BA/F3	Mk\2SpVv[3Srb36gZZN{[Xl?		NIjhTWQ4OiCqcoO=	MnXITY5pcWKrdHnvckBw\iCSRFfGVoFteGijIG[1OlFFN0R6NELWJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJCN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDDndo94fGhiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCJSUWwJF0hOC53Nkeg{txONg>?	NHT5dJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
K562	NVLNRVdYS3m2b4TvfIlkcXS7IHHzd4F6		MkX6OFghcHK\|	M4f3cmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvPThizszNMi=>	MkexQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{OUWzPFAoRjJzMkm1N\|gxRC:jPh?=
BA/F3	NHfqRnJEgXSxdH;4bYNqfHliYYPzZZk>		M4mwOVczKGi{cx?=	NHW0NlZEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiRUO1PXYhdXW2YX70JIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDBwNUmg{txONg>?	M{XmPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{CxO\|A{Lz5{M{OwNVcxOzxxYU6=
BA/F3	NX6zS3htTnWwY4Tpc44h[XO\|YYm=		M{PmPVczKGi{cx?=	NEfqNFJKdmirYnn0bY9vKG:oIFLDVk9CSkxicEKxNE1OOzVzVDDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMNThiYYPzZZktKEeLNUCgQUAxNjZ{NTFOwG0v	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
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NCI-H510A	Mn74S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NIfFN3VKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVExSSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMUeuNlQ1OiEQvF2u	M33KbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
TE-441-T	Mn:4S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NGPMdlJKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUS0NU1VKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSBzNz6yPFg3KM7:TT6=	MkewQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
HH	Ml\XS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			M1Hx[GlvcGmkaYTpc44hd2ZiaIXtZY4hUEhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEG3MlM6QTlizszNMi=>	NXTIUHo3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
LC4-1	MWrHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			MXXJcohq[mm2aX;uJI9nKGi3bXHuJGxEPC1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCxPE4xPjV{IN88UU4>	Mk\FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
KARPAS-45	NEPnWnNIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NULvXGloUW6qaXLpeIlwdiCxZjDoeY1idiCNQWLQRXMuPDViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEG4MlE5PDhizszNMi=>	NGLKcGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
LB1047-RCC	M4XIbmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			M4rTSWlvcGmkaYTpc44hd2ZiaIXtZY4hVEJzMES3MXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMUiuOFQ2OiEQvF2u	M1j6SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
NKM-1	NY\TN3FXT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			M{O1eGlvcGmkaYTpc44hd2ZiaIXtZY4hVkuPLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFE6NjN3NUKg{txONg>?	NHjtcZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
SCLC-21H	MXLHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			MkHITY5pcWKrdHnvckBw\iCqdX3hckBUS0yFLUKxTEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOjBwMUK0OkDPxE1w	M{DwZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
RS4-11	NV3XSGRDT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			MXLJcohq[mm2aX;uJI9nKGi3bXHuJHJUPC1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gNlAvOzNyODFOwG0v	M2HQUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
ALL-PO	M2X6bGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			M1vubGlvcGmkaYTpc44hd2ZiaIXtZY4hSUyOLWDPJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzOC56MUS5JO69VS5?	NGrRTJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
GDM-1	M13IZ2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NGPTZ2lKdmirYnn0bY9vKG:oIHj1cYFvKEeGTT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzOi53OUS1JO69VS5?	NWjHdVFIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
DMS-79	NGCydXRIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NUf1cWROUW6qaXLpeIlwdiCxZjDoeY1idiCGTWOtO\|kh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDJ2LkS5N\|Qh\|ryPLh?=	NV7oWmdtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
MPP-89	Ml\iS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			M4TteGlvcGmkaYTpc44hd2ZiaIXtZY4hVVCSLUi5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzPS54OEe0JO69VS5?	NVLZbWFvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
NB10	NH;JUXhIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NV;OPXUxUW6qaXLpeIlwdiCxZjDoeY1idiCQQkGwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzPi52NzFOwG0v	NIfU[lI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
LS-513	MXPHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			M2SxTWlvcGmkaYTpc44hd2ZiaIXtZY4hVFNvNUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzPi56OES3JO69VS5?	M4rXfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
L-540	MULHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			MY\Jcohq[mm2aX;uJI9nKGi3bXHuJGwuPTRyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCyOk46OTR\|IN88UU4>	M3T4fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
ES1	MmrOS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			M1;rcGlvcGmkaYTpc44hd2ZiaIXtZY4hTVNzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCyO{42OjFizszNMi=>	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
NTERA-S-cl-D1	MVrHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NW[4RVRjUW6qaXLpeIlwdiCxZjDoeY1idiCQVFXSRU1UNWOuLVSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA{OC53MEmzJO69VS5?	NUPHS2ZQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
EW-1	NXK2[XhPT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			NX\T[YJzUW6qaXLpeIlwdiCxZjDoeY1idiCHVz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA{Oi57NEW0JO69VS5?	M3L4XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
Calu-6	M{fXOmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			M1e4VGlvcGmkaYTpc44hd2ZiaIXtZY4hS2GudT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA{Oy5zOEW1JO69VS5?	M4\mO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
CTV-1	Ml6yS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			MmS0TY5pcWKrdHnvckBw\iCqdX3hckBEXFZvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gN\|MvQTd6OTFOwG0v	NIO5eI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
YT	MWDHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NF7u[lJKdmirYnn0bY9vKG:oIHj1cYFvKFmWIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCzPE42OjB7IN88UU4>	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
TE-6	MVPHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NFPlTlZKdmirYnn0bY9vKG:oIHj1cYFvKFSHLU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQyNjJ5OUeg{txONg>?	NFPDNm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
HT-144	M2HlWGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			M1jwW2lvcGmkaYTpc44hd2ZiaIXtZY4hUFRvMUS0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1OS53NEi2JO69VS5?	NI\1dXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
EW-13	Mn7ZS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			MmjuTY5pcWKrdHnvckBw\iCqdX3hckBGXy1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gOFIvOjd7MTFOwG0v	NXnT[YFjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
KALS-1	MmP2S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			MnLiTY5pcWKrdHnvckBw\iCqdX3hckBMSUyVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ{NjF\|Mkig{txONg>?	NED5UY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
MOLT-16	NFrleJBIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			MnfjTY5pcWKrdHnvckBw\iCqdX3hckBOV0yWLUG2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1PS5yN{WyJO69VS5?	MmW1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
D-336MG	MmP3S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			M{H2TWlvcGmkaYTpc44hd2ZiaIXtZY4hTC1\|M{\NS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDVwOUW5PUDPxE1w	MoLZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
TE-11	NV;K[mRoT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			MkflTY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gOFYvPjV\|IN88UU4>	M4SxTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
EB2	NIe0cpBIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NEOy[4JKdmirYnn0bY9vKG:oIHj1cYFvKEWEMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gOFYvPjl7IN88UU4>	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
SK-N-DZ	MYXHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NHKxVHVKdmirYnn0bY9vKG:oIHj1cYFvKFONLV6tSHoh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDR6LkC5OlEh\|ryPLh?=	NEPSVWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
SW684	NVS3R5F6T3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			M4jxNGlvcGmkaYTpc44hd2ZiaIXtZY4hW1d4OESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ5NjJ4OUWg{txONg>?	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
EW-18	MVjHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			MWDJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTF6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTC0PE41Ozl3IN88UU4>	M{nlbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-STAT3 / STAT3 / p-STAT5 / STAT5; PubMed: 18981115 J Immunol For phospho-STAT3 and Phospho-STAT5 detection, cells were then activated for 6 hrs with anti-CD3 and anti-CD28 Ab. Equivalent amounts of protein from cell lysates were separated by SDS-PAGE and western blot analysis was then performed using anti-phospho S䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖 p-ZAP70 / ZAP70 / p-LAT / LAT; PubMed: 18981115 J Immunol For the analysis of imatinib interference with early TCR signaling events, cells were activated for 5 min with anti-CD3 and anti-CD28 Abs and blots were probed with anti-phospho ZAP70, anti-ZAP70, anti-phospho LAT or anti-LAT antibodies. Untreated, non-ac䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 	18981115
Immunofluorescence	RelB; PubMed: 20371728 Mol Cancer Ther Nuclear proteins were extracted from the untreated and treated cells and nuclear levels of RelA and RelB were confirmed by immunocytochemistry Cortactin / F-actin; PubMed: 20937825 J Biol Chem NIH3T3-SrcY527F cells were treated with DMSO or with 10 μm STI571 for 16 h, fixed and co-stained for cortactin (red, left panels) and F-actin (green, middle panels). Merged fields (right panels) demonstrate co-localization between cortactin and F-actin at䲧疝Ỵ疞㧀疜	20371728 20937825
Growth inhibition assay	Cell viability ; PubMed: 28435223 Drug Des Devel Ther (C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. 䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺	28435223

体内研究

Imatinib抑制从新鲜的人小细胞肺癌外科样品来源的SCLC6，SCLC61和SCLC108异种移植肿瘤，抑制率分别是80％，40％和78％，且对SCLC74生长长无显著抑制。^[5] 在高脂肪喂养的ApoE（-/-）小鼠中，通过管饲法给药10 mg/kg，20 mg/kg和40 mg/kg Imatinib，和对照组相比高脂诱导的脂质染色区域减少了30％，27％和35％，并且颈动脉脂质积聚得到抑制。^[6]

激酶实验：^[1]	- 合并 PDGF受体激酶活性 : PDGF受体是由BALB / c3T3细胞提取物免疫共沉淀所得，通过兔抗PDGF受体冰上处理2小时所得。蛋白A-琼脂糖珠被用于收集抗原-抗体复合物。免疫沉淀物用TNET（50 mM Tris，pH 7.5，140 mM氯化钠，5mM的EDTA，1％的Triton X-100）洗涤两次，用TNE（50 mM Tris，pH 7.5，140 mM EDTA）洗涤一次，并用激酶缓冲液（20 mM的Tris，pH 7.5, 10 mM氯化镁）洗涤一次。用PDGF（50 ng/mL）在4℃下刺激10分钟后，不同浓度的药物加入到反应混合物中。PDGF受体激酶活性是通过温浴10 μCi [³³P]-ATP和l μM ATP 10分钟来确定。免疫复合物经SDS-PAGE上的7.5％凝胶上分离。
细胞实验：^[3]	- 合并 Cell lines: BON-1 和 NCI-H727细胞 Concentrations: 约100 μM Incubation Time: 48小时 Method: BON-1细胞和NCI-H727细胞接种到平底96孔板中三个复孔，并在含10％胎牛血清的DMEM或RPMI1640完全培养基中贴壁过夜，然后更换为血清培养基（阴性对照）或含不同浓度梯度Imatinib的无血清培养基。48小时（对照培养物没有达到汇合）后，代谢活性细胞的数量是由3-（4,5-二甲基吡啶-2-基）-2,5-二苯基溴化测定，由帕卡德光谱酶标仪测定540nm处吸光度。生长抑制通过以下公式计算：抑制率=(1 − a / b) × 100%，其中a和b分别是治疗组和对照组的吸光度值。 (Only for Reference)
动物实验：^[5]	- 合并 Animal Models: SCLC6, SCLC61, SCLC 74 and SCLC108 小细胞肺癌注入瑞士小鼠 (nu/nu, 雌性）。 Dosages: 70或100 mg/kg Administration: 腹腔注射 (Only for Reference)

参考文献

- 合并

溶解度 (25°C)

体外	DMSO	118 mg/mL (200.09 mM)
	Water	118 mg/mL (200.09 mM)
	Ethanol	Insoluble

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Imatinib (STI571) Mesylate SDF

分子量	589.71
化学式	C₂₉H₃₁N₇O.CH₄SO₃
CAS号	220127-57-1
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	Gleevec, Glivec, CGP-57148B

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2020-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02687425	Unknown status	Drug: Pioglitazone\|Drug: imatinib mesylate	Leukemia Myelogenous Chronic BCR-ABL Positive	Meng Li\|Tongji Hospital	February 2016	Phase 2
NCT02303899	Unknown status	Drug: Gemcitabine\|Drug: Imatinib mesylate	Mesothelioma Malignant	Istituto Clinico Humanitas	November 2014	Phase 2
NCT01898377	Terminated	Drug: Imatinib mesylate Mycophenolate mofetil	Chronic Graft-versus-host Disease	Seoul National University Hospital	August 2013	Phase 2
NCT02891395	Completed	Drug: Imatinib Mesylate and Nilotinib	Graft Versus Host Disease	University Hospital Lille\|Novartis	December 24 2012	Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

选择性强的Bcr-Abl抑制剂

Nilotinib (AMN-107) : Bcr-Abl-selective, IC50<30 nM.
活性最高的Bcr-Abl抑制剂

GZD824 : Bcr-Abl(WT), IC50=0.34 nM; Bcr-Abl(T315I), IC50=0.68 nM.
FDA批准的Bcr-Abl抑制剂

Dasatinib : Approved by FDA for CML and Ph+ ALL.
最新的Bcr-Abl抑制剂

GZD824 : Orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

研究领域

产品类型

定制您的化合物库

Imatinib (STI571) Mesylate

客户使用Selleck生产的Imatinib (STI571) Mesylate发表文献159篇：

产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Imatinib (STI571) Mesylate SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2020-01-06)

技术支持

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

相关Bcr-Abl产品