Imatinib (STI571) Mesylate

For research use only. Not for use in humans.

目录号：S1026 别名： Gleevec, Glivec, CGP-57148B 中文名称：甲磺酸伊马替尼

Imatinib (STI571) Mesylate Chemical Structure

CAS No. 220127-57-1

Imatinib Mesylate (STI571, CGP-57148B)是一种口服生物有效的Imatinib甲磺酸盐，是一种多靶点抑制剂，作用于v-Abl，c-Kit和PDGFR，在无细胞和细胞试验中，IC50分别为0.6 μM，0.1 μM 和0.1 μM。Imatinib Mesylate (STI571) 可诱导自噬。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 1567.38	现货
100mg	RMB 780.01	现货
250mg	RMB 1603.82	现货
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客户使用Selleck生产的Imatinib (STI571) Mesylate发表文献198篇：

Cancer Cell, 2021, S1535-6108(21)00659-0

PubMed: 34971568 ( click the link to review the publication )

Science, 2020, 370(6513)eabc2754

PubMed: 33004676 ( click the link to review the publication )

Cell Stem Cell, 2020, 10;S1934-5909(20)30144-2

PubMed: 32413332 ( click the link to review the publication )

Cell Metab, 2018, 28(6):817-832

PubMed: 30244971 ( click the link to review the publication )

Cancer Cell, 2014, 26(6):840-50

PubMed: 25490448 ( click the link to review the publication )

Cell Stem Cell, 2012, 10(2):210-7

PubMed: 22305570 ( click the link to review the publication )

Clin Cancer Res, 2021, 27(9):2533-2548

PubMed: 33619172 ( click the link to review the publication )

Cell Rep, 2021, 37(1):109788

PubMed: 34610309 ( click the link to review the publication )

Cancers (Basel), 2021, 14(1)187

PubMed: 35008351 ( click the link to review the publication )

Cancers (Basel), 2021, 13(15)3699

PubMed: 34359600 ( click the link to review the publication )

Cancers (Basel), 2021, 13(14)3635

PubMed: 34298852 ( click the link to review the publication )

Cell Death Dis, 2021, 12(11):962

PubMed: 34667163 ( click the link to review the publication )

Cell Death Discov, 2021, 7(1):139

PubMed: 34117218 ( click the link to review the publication )

Cell Death Dis, 2021, 12(5):456

PubMed: 33963175 ( click the link to review the publication )

Clin Sci (Lond), 2021, 135(19):2243-2263

PubMed: 34569605 ( click the link to review the publication )

Front Cell Dev Biol, 2021, 9:695225

PubMed: 34568318 ( click the link to review the publication )

Hum Mol Genet, 2021, ddab011

PubMed: 33438013 ( click the link to review the publication )

Hum Mol Genet, 2021, ddab014

PubMed: 33450762 ( click the link to review the publication )

Cancer Sci, 2021, 112(2):655-667

PubMed: 33247506 ( click the link to review the publication )

Cell Microbiol, 2021, e13398

PubMed: 34697890 ( click the link to review the publication )

Lab Invest, 2021, 10.1038/s41374-021-00704-4

PubMed: 34837064 ( click the link to review the publication )

Biochem Pharmacol, 2021, 190:114658

PubMed: 34146540 ( click the link to review the publication )

Invest New Drugs, 2021, 10.1007/s10637-020-01028-8

PubMed: 33403501 ( click the link to review the publication )

World J Gastroenterol, 2021, 27(32):5392-5403

PubMed: 34539140 ( click the link to review the publication )
ChemMedChem, 2021, 16(6):1034-1046

PubMed: 33275308 ( click the link to review the publication )

Ann Hematol, 2021, 10.1007/s00277-020-04357-z

PubMed: 34110462 ( click the link to review the publication )

PLoS One, 2021, 16(7):e0250442

PubMed: 34214082 ( click the link to review the publication )

Am J Med Genet A, 2021, 10.1002/ajmg.a.62603

PubMed: 34894066 ( click the link to review the publication )

Hum Cell, 2021, 10.1007/s13577-021-00639-4

PubMed: 34731453 ( click the link to review the publication )

Hum Cell, 2021, 10.1007/s13577-021-00579-z

PubMed: 34304386 ( click the link to review the publication )

Exp Ther Med, 2021, 22(1):735

PubMed: 34055052 ( click the link to review the publication )

Immunohorizons, 2021, 5(8):687-702

PubMed: 34433624 ( click the link to review the publication )

Blood, 2020, 8 pii: blood

PubMed: 32270193 ( click the link to review the publication )

Clin Cancer Res, 2020, 21;clincanres31422019

PubMed: 32439698 ( click the link to review the publication )

Genome Med, 2020, 18;12(1):17

PubMed: 32070411 ( click the link to review the publication )

Cancer Res, 2020, canres.1992.2020

PubMed: 33203698 ( click the link to review the publication )

Cell Rep, 2020, 24;30(12):3951-3963 e4

PubMed: 32209458 ( click the link to review the publication )

J Hematol Oncol, 2020, 13(1):80

PubMed: 32552902 ( click the link to review the publication )

Cancers (Basel), 2020, 12(6):E1674

PubMed: 32599808 ( click the link to review the publication )

Cancers (Basel), 2020, 13;12(2) pii: E436

PubMed: 32069833 ( click the link to review the publication )

Cancers (Basel), 2020, 25;12(5)

PubMed: 32344828 ( click the link to review the publication )

PLoS Pathog, 2020, 16(8):e1008823

PubMed: 32845931 ( click the link to review the publication )

Br J Cancer, 2020, 10.1038/s41416-020-0952-1

PubMed: 32572172 ( click the link to review the publication )

Aging (Albany NY), 2020, 12(17):17662-17680

PubMed: 32927433 ( click the link to review the publication )

Front Bioeng Biotechnol, 2020, 20;8:482

PubMed: 32509756 ( click the link to review the publication )

Cancer Sci, 2020, 10.1111/cas.14750

PubMed: 33247506 ( click the link to review the publication )

Front Oncol, 2020, 12;10:696

PubMed: 32528877 ( click the link to review the publication )

J Cell Mol Med, 2020, 10.1111/jcmm.15830

PubMed: 32914934 ( click the link to review the publication )
Int J Mol Sci, 2020, 21(1)

PubMed: 31948066 ( click the link to review the publication )

Sci Rep, 2020, 10(1):11269

PubMed: 32647179 ( click the link to review the publication )

Cancer Cell Int, 2020, 19;20:58

PubMed: 32099531 ( click the link to review the publication )

Oncol Rep, 2020, 44(5):2152-2164

PubMed: 32901871 ( click the link to review the publication )

Drug Des Devel Ther, 2020, 12;14:1799-1811

PubMed: 32494122 ( click the link to review the publication )

J Pharm Biomed Anal, 2020, 195:113864

PubMed: 33387839 ( click the link to review the publication )

J Mol Neurosci, 2020, 10.1007/s12031-020-01735-0

PubMed: 33165739 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00420-z

PubMed: 32870449 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00425-8

PubMed: 32886306 ( click the link to review the publication )

FEBS Open Bio, 2020, 10.1002/2211-5463.13052

PubMed: 33289342 ( click the link to review the publication )

Immun Inflamm Dis, 2020, 10.1002/iid3.383

PubMed: 33350598 ( click the link to review the publication )

J Pers Med, 2020, 10(4)E234

PubMed: 33212994 ( click the link to review the publication )

Cold Spring Harb Mol Case Stud, 2020, mcs.a005710

PubMed: 33144287 ( click the link to review the publication )

Hemasphere, 2020, 4(6):e497

PubMed: 33196013 ( click the link to review the publication )

Biochem Biophys Res Commun, 2020, 529(3):699-706

PubMed: 32736695 ( click the link to review the publication )

Neoplasia, 2020, 22(10):470-483

PubMed: 32818841 ( click the link to review the publication )

J Cell Mol Med, 2020, 10.1111/jcmm.15612

PubMed: 32667731 ( click the link to review the publication )

Ann N Y Acad Sci, 2020, 1467(1):77-93

PubMed: 31930541 ( click the link to review the publication )

bioRxiv, 2020, 2020/9/20.4.7.30734

PubMed: 32511305 ( click the link to review the publication )

Nat Cell Biol, 2019, 21(6):778-790

PubMed: 31160710 ( click the link to review the publication )

Mol Cell, 2019, 75(2):252-266

PubMed: 31202577 ( click the link to review the publication )

Autophagy, 2019, 15(12):2076-2090

PubMed: 30929559 ( click the link to review the publication )

Cell Rep, 2019, 29(13):4471-4481.e6

PubMed: 31875554 ( click the link to review the publication )

Elife, 2019, 8e48725

PubMed: 31385803 ( click the link to review the publication )
J Exp Clin Cancer Res, 2019, 18;38(1):85

PubMed: 30777101 ( click the link to review the publication )

Cancers (Basel), 2019, 11(12)E2043

PubMed: 31861239 ( click the link to review the publication )

Gastric Cancer, 2019, 10.1007/s10120-019-00977-1

PubMed: 31197522 ( click the link to review the publication )

Hum Reprod, 2019, 34(3):506-518

PubMed: 30597012 ( click the link to review the publication )

J Cell Mol Med, 2019, 23(12):8314-8327

PubMed: 31576676 ( click the link to review the publication )

Sci Rep, 2019, 9(1):1897

PubMed: 30760778 ( click the link to review the publication )

Eur J Pharmacol, 2019, 17:172559

PubMed: 31325435 ( click the link to review the publication )

PLoS One, 2019, 14(10):e0224237

PubMed: 31618259 ( click the link to review the publication )

Int J Med Sci, 2019, 16(8):1149-1156

PubMed: 31523178 ( click the link to review the publication )

Cancer Invest, 2019, 37(2):99-112

PubMed: 30836770 ( click the link to review the publication )

Res Vet Sci, 2019, 124:1-9

PubMed: 30716585 ( click the link to review the publication )

JCI Insight, 2019, 4(23)131434

PubMed: 31622281 ( click the link to review the publication )

Front Immunol, 2019, 10:1876

PubMed: 31447858 ( click the link to review the publication )

Nat Biomed Eng, 2018, 2(8):578-588

PubMed: 31015631 ( click the link to review the publication )

Sci Transl Med, 2018, 10(427)

PubMed: 29437150 ( click the link to review the publication )

Acta Neuropathol, 2018, 135(5):779-798

PubMed: 29305721 ( click the link to review the publication )

Blood, 2018, 131(14):1532-1544

PubMed: 29437554 ( click the link to review the publication )

Clin Cancer Res, 2018, 1;24(1):145-157

PubMed: 29070525 ( click the link to review the publication )

Cell Rep, 2018, 23(11):3127-3136

PubMed: 29898385 ( click the link to review the publication )

Elife, 2018, 7e36656

PubMed: 29901437 ( click the link to review the publication )

J Exp Clin Cancer Res, 2018, 25;37(1):170

PubMed: 30045750 ( click the link to review the publication )

Cell Death Discov, 2018, 4:48

PubMed: 29707241 ( click the link to review the publication )

Front Immunol, 2018,

PubMed: 30127787 ( click the link to review the publication )

Mol Cancer Ther, 2018, 17(7):1526-1539

PubMed: 29654068 ( click the link to review the publication )
Endocr Relat Cancer, 2018, 25(4):471-480

PubMed: 29440231 ( click the link to review the publication )

Neoplasia, 2018, 20(8):857-870

PubMed: 30025229 ( click the link to review the publication )

Pharmacol Res, 2018, 133:121-131

PubMed: 29730267 ( click the link to review the publication )

Eur J Med Chem, 2018, 154:101-109

PubMed: 29778892 ( click the link to review the publication )

Cancer Sci, 2018, 109(9):2792-2800

PubMed: 29957833 ( click the link to review the publication )

J Cell Physiol, 2018, 233(9):7467-7479

PubMed: 29663362 ( click the link to review the publication )

J Cell Sci, 2018,

PubMed: 29487179 ( click the link to review the publication )

Biochem Pharmacol, 2018, 10.1016/j.bcp.2018.10.011

PubMed: 30342021 ( click the link to review the publication )

Toxicol Sci, 2018, 165(1):232-243

PubMed: 30165626 ( click the link to review the publication )

Am J Physiol Lung Cell Mol Physiol, 2018, 315(6):L965-L976

PubMed: 30211651 ( click the link to review the publication )

Biomed Pharmacother, 2018, 106:403-410

PubMed: 29966986 ( click the link to review the publication )

Cell Signal, 2018, 51:191-198

PubMed: 30075184 ( click the link to review the publication )

PLoS One, 2018, 13(2):e0191890

PubMed: 29389967 ( click the link to review the publication )

Biochem Biophys Res Commun, 2018, 502(1):110-115

PubMed: 29787755 ( click the link to review the publication )

Int J Clin Exp Pathol, 2018, 11(1):179-188

PubMed: 31938099 ( click the link to review the publication )

NPJ Syst Biol Appl, 2018, 4:1

PubMed: 29263797 ( click the link to review the publication )

Hemasphere, 2018, 2(3):e41

PubMed: 31723769 ( click the link to review the publication )

Nat Commun, 2017, 1;8(1):1232

PubMed: 29089541 ( click the link to review the publication )

Dev Cell, 2017, 42(2):117-129

PubMed: 28689759 ( click the link to review the publication )

Theranostics, 2017, 7(5):1333-1345

PubMed: 28435469 ( click the link to review the publication )

Cancer Res, 2017, 77(5):1142-1154

PubMed: 27899378 ( click the link to review the publication )

Cell Rep, 2017,

PubMed: 28564604 ( click the link to review the publication )

Cancer Lett, 2017, 395:20-30

PubMed: 28286261 ( click the link to review the publication )

Cancer Lett, 2017, 393:113-124

PubMed: 28153790 ( click the link to review the publication )
Cell Death Dis, 2017, 8(10):e3117

PubMed: 29022905 ( click the link to review the publication )

Arch Toxicol, 2017, 91(8):2921-2938

PubMed: 28032146 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(4):671-680

PubMed: 28138031 ( click the link to review the publication )

Sci Rep, 2017,

PubMed: 28638122 ( click the link to review the publication )

Exp Cell Res, 2017, 353(2):72-78

PubMed: 28267438 ( click the link to review the publication )

BMC Cancer, 2017,

PubMed: 28806950 ( click the link to review the publication )

Bioconjug Chem, 2017, 28(10):2608-2619

PubMed: 28903003 ( click the link to review the publication )

Molecules, 2017, 22(12)

PubMed: 29206199 ( click the link to review the publication )

Leuk Lymphoma, 2017, 58(8):1903-1913

PubMed: 27931141 ( click the link to review the publication )

Reprod Fertil Dev, 2017, 29(7):1356-1368

PubMed: 27279472 ( click the link to review the publication )

Zhonghua Xue Ye Xue Za Zhi, 2017, 38(12):1036-1042

PubMed: 29365396 ( click the link to review the publication )

Oncotarget, 2017, 8(27):43662-43677

PubMed: 28599273 ( click the link to review the publication )

Oncotarget, 2017, 8(54):91841-91859

PubMed: 29190880 ( click the link to review the publication )

Cell Stem Cell, 2017, 20(2):233-246

PubMed: 27989769 ( click the link to review the publication )

Cell, 2017, 170(3):507-521

PubMed: 28735753 ( click the link to review the publication )

Blood, 2016, 28;127(17):2131-43

PubMed: 26864341 ( click the link to review the publication )

Hepatology, 2016, 64(2):488-500

PubMed: 27015352 ( click the link to review the publication )

EMBO Mol Med, 2016, 1;8(2):105-16

PubMed: 26758680 ( click the link to review the publication )

Stem Cell Res, 2016, 16(3):795-806

PubMed: 27161312 ( click the link to review the publication )

Mol Cancer Ther, 2016, 15(1):94-105

PubMed: 26637365 ( click the link to review the publication )

Mol Cancer Ther, 2016, 15(10):2302-2313

PubMed: 27474148 ( click the link to review the publication )

Mol Pharm, 2016, 13(10):3457-3467

PubMed: 27560921 ( click the link to review the publication )

Traffic, 2016, 17(4):351-68

PubMed: 26650385 ( click the link to review the publication )

Cancer Sci, 2016, 107(6):782-90

PubMed: 27002306 ( click the link to review the publication )
Transl Oncol, 2016, 9(6):540-547

PubMed: 27835791 ( click the link to review the publication )

Oncol Rep, 2016, 35(1):197-204

PubMed: 26499059 ( click the link to review the publication )

Mol Vis, 2016, 22:1213-1220

PubMed: 27746675 ( click the link to review the publication )

Oncotarget, 2016, 7(29):45916-45925

PubMed: 27322141 ( click the link to review the publication )

Oncotarget, 2016, 7(18):26709-23

PubMed: 27050374 ( click the link to review the publication )

Nat Commun, 2015, 6:7002

PubMed: 25926053 ( click the link to review the publication )

J Clin Invest, 2015, 125(6):2317-34

PubMed: 25915587 ( click the link to review the publication )

Nat Commun, 2015, 6:8481

PubMed: 26412466 ( click the link to review the publication )

Genes Dev, 2015, 29(7):732-45

PubMed: 25838542 ( click the link to review the publication )

Cell Rep, 2015, 11(1):98-110

PubMed: 25843712 ( click the link to review the publication )

Cell Rep, 2015, 10.1016/j.celrep.2015.05.012

PubMed: 26051937 ( click the link to review the publication )

J Urol, 2015, 194(6):1797-805

PubMed: 26055827 ( click the link to review the publication )

Phytother Res, 2015, 29(7):1062-72

PubMed: 25857479 ( click the link to review the publication )

Phytother Res, 2015, 29(3):434-43

PubMed: 25583173 ( click the link to review the publication )

PLoS One, 2015, 10(3):e0120531

PubMed: 25781619 ( click the link to review the publication )

Biomed Res Int, 2015, 2015:368976

PubMed: 25629045 ( click the link to review the publication )

Oncol Lett, 2015, 10(5):2835-2841

PubMed: 26722250 ( click the link to review the publication )

Brain Behav, 2015, 3;5(11):e00359

PubMed: 26664784 ( click the link to review the publication )

Sci Transl Med, 2014, 6(261):261ra152

PubMed: 25378644 ( click the link to review the publication )

Nat Protoc, 2014, 10(1):149-68

PubMed: 25521791 ( click the link to review the publication )

J Clin Invest, 2014, 124(8):3378-90

PubMed: 24960160 ( click the link to review the publication )

Leukemia, 2014, 28(4):977-9

PubMed: 24186003 ( click the link to review the publication )

Oncogene, 2014, 33(2):236-45

PubMed: 23246970 ( click the link to review the publication )

Stem Cells, 2014, 32(9):2324-37

PubMed: 24806995 ( click the link to review the publication )
Mol Cancer Ther, 2014, 13(10):2276-87

PubMed: 25122069 ( click the link to review the publication )

Cancer Cell Int, 2014, 14(1):89

PubMed: 25253994 ( click the link to review the publication )

Int J Oncol, 2014, 44(5):1661-8

PubMed: 24585095 ( click the link to review the publication )

J Alzheimers Dis, 2014, 41(3):729-37

PubMed: 24662099 ( click the link to review the publication )

PLoS One, 2014, 9(1):e84900

PubMed: 24454763 ( click the link to review the publication )

PLoS One, 2014, 9(10):e109441

PubMed: 25279552 ( click the link to review the publication )

Biochem Biophys Res Commun, 2014, 450(4):1600-5

PubMed: 25026552 ( click the link to review the publication )

Biomed Res Int, 2014, 2014:682010

PubMed: 24524084 ( click the link to review the publication )

Graefes Arch Clin Exp Ophthalmol, 2014, 10.1007/s00417-014-2674-7

PubMed: 24874745 ( click the link to review the publication )

Cancer Immunol Res, 2014, 2(12):1186-98

PubMed: 25300860 ( click the link to review the publication )

University of Alberta, 2014, Yahya Muhammad Fiteih

PubMed: ( click the link to review the publication )

Cancer Res, 2013, 73(12):3661-70

PubMed: 23576565 ( click the link to review the publication )

Pigment Cell Melanoma Res, 2013, 26(4):518-26

PubMed: 23582185 ( click the link to review the publication )

J Mol Cell Cardiol, 2013, 66:177-88

PubMed: 24326234 ( click the link to review the publication )

J Biol Chem, 2013, 288(34):24503-17

PubMed: 23821550 ( click the link to review the publication )

Drug Metab Dispos, 2013, 10.1124/dmd.113.054189

PubMed: 24335466 ( click the link to review the publication )

Proteomics, 2013, 13(23-24):3554-62

PubMed: 24167056 ( click the link to review the publication )

Leuk Res, 2013, 37(11):1532-7

PubMed: 23972517 ( click the link to review the publication )

Sci Transl Med, 2012, 4(131):131ra50

PubMed: 22539774 ( click the link to review the publication )

Leukemia, 2012, 27(4):932-40

PubMed: 23032722 ( click the link to review the publication )

J Invest Dermatol, 2012, 132(7):1850-9

PubMed: 22437314 ( click the link to review the publication )

Biochemistry, 2012, 51(25):5153-9

PubMed: 22681044 ( click the link to review the publication )

PLoS One, 2012, 7(8):e42310

PubMed: 22879938 ( click the link to review the publication )

Exp Hematol, 2012, 41(4):335-45.e3

PubMed: 23287417 ( click the link to review the publication )
Leuk Res, 2012, 37(2):183-9

PubMed: 23218026 ( click the link to review the publication )

Anticancer Res, 2012, 33(1):175-81

PubMed: 23267143 ( click the link to review the publication )

FASEB J, 2011, 25(10):3661-73

PubMed: 21705667 ( click the link to review the publication )

Pharm Res, 2011, 28(2):337-63

PubMed: 20945153 ( click the link to review the publication )

J Pharm Biomed Anal, 2011, 56(2):173-82

PubMed: 21652160 ( click the link to review the publication )

PLoS One, 2010, 5(11):e14143

PubMed: 21152443 ( click the link to review the publication )

产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

产品描述

靶点

PDGFR ^[1] (Cell-free assay)	c-Kit ^[2] (M-07e cells)	v-Abl ^[1] (Cell-free assay)
100 nM	100 nM	600 nM

体外研究

抑制酪氨酸和丝氨酸/苏氨酸蛋白激酶的体外测定法显示Imatinib有效抑制V-Abl酪氨酸激酶和PDGFR，IC50分别为0.6 μM和0.1 μM。^[1] Imatinib抑制SLF-依赖性激活的野生型的c-kit激酶活性，IC 50约为0.1 μM，这类似抑制PDGFR所需的浓度。^[2] Imatinib表现出对人支气管类癌细胞系NCI-H727和人胰腺类癌细胞系BON-1的抑制作用，IC50分别为32.4 μM和32.8 μM。 ^[3] 最近的一项研究显示，Imatinib通过下调hERG1 K(+)通道发挥在慢性粒细胞白血病的抗白血病作用，hERG1 K(+)通道在白血病细胞中高表达并表现有利于白血病出现。^[4]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
GIST882	NWf2VFZlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MkLtPVYhcA>?	NYrXVYUyUUN3ME2xMlch\|ryP	NWDWe5RuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFAzOTJpPkK0PVAxOjF{PD;hQi=>
K562	NYjvNplZS3m2b4TvfIlkcXS7IFHzd4F6		NWLpN3JbOjRiaB?=	NInqN5RKSzVyPUCuNlEh\|ryP	MkTtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMECyNFcoRjJ{MECwNlA4RC:jPh?=
MCF-7	Mkf4R5l1d3SxeHnjbZR6KEG\|c3H5		NWq0VmpiOjRiaB?=	Mkn6TWM2OD1yLkizJO69VQ>?	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjByMEKwO{c,OjJyMECyNFc9N2F-
MDA-MB-23	NG\kSmFEgXSxdH;4bYNqfHliQYPzZZk>		M4W2clI1KGh?	M3q0PGlEPTB;MT64JO69VQ>?	NIPGVII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkCwNFIxPyd-MkKwNFAzODd:L3G+
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BA/F3	MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MoTmOFghcHK\|	MmrvS5Jwf3SqIHnubIljcXSrb36gc4YhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yC5aXzkMZR6eGViQnPyMWFjdCCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yOEmg{txONg>?	NVi1VHlDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1OlIzOTdpPkK2OVYzOjF5PD;hQi=>
K562	M{LLfGZ2dmO2aX;uJIF{e2G7		MonxN\|AhdWmwcx?=	NIn6XmtKdmirYnn0bY9vKG:oIHvpco9j\WGmIHLpcoRqdmdidH:gSGRTOSCrbjDoeY1idiCNNU[yJINmdGy\|IHnuZ5Vj[XSnZDDmc5IhOzBibXnud{BjgSCrVGLBVUBz\WGpZX70MYJie2WmIH3hd5Mhe3CnY4Tyc41mfHKrYzDt[ZRpd2RuIFnDOVAhRSByLkC5JO69VS5?	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ6MEK2NUc,Ojh{OECyOlE9N2F-
Ba/F3	M1;UO2Z2dmO2aX;uJIF{e2G7		MmXyOFghcHK\|	NUfieJlCUW6qaXLpeIlwdiCxZjD3bYxlKHS7cHWgRmNTNUGETEGgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hdW:3c3WgRoEwTjNiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOFghcHK\|IHL5JGJzcXSnTHnnbJQhdHWlaX\ldoF{\SCjc4PhfUwhT0l3MDC9JFAvODlyNTFOwG0v	Mor0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzM{e5PFEoRjNyMUO3PVgyRC:jPh?=
BA/F3	NWfTb2x3S3m2b4TvfIlkcXS7IHHzd4F6		NGHsdog1QCCqcoO=	NYTVZVlsS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNidILhcpNn\WO2ZXSge4l1cCC5aXzkJJR6eGViQnPyMWFjdCCjZoTldkA1QCCqcoOgZpkhYFSWIHHzd4F6NCCLQ{WwJF0hOC5yOUKg{txONg>?	MonQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MEC4NFYoRjJ\|NkCwPFA3RC:jPh?=
GIST882	MXTGeY5kfGmxbjDhd5NigQ>?			NFuyboFKdmirYnn0bY9vKG:oIHj1cYFvKEuLVDDheZRweGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJGdKW1R6OEKgZ4VtdHNiYomgSWxKW0FuIFnDOVAhRSByLkC5O{DPxE1w	NHnrcWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO\|U{QCd-MkC4NVc2Ozh:L3G+
GIST882	NWS0[ZN6TnWwY4Tpc44h[XO\|YYm=			NXzhXpBCUW6qaXLpeIlwdiCxZjDLTXQhUzZ2MlWgcZV1[W62IHH1eI9xcG:\|cHjvdplt[XSrb36gLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hcHWvYX6gS2lUXDh6MjDj[YxteyCkeTDFUGlUSSxiSVO1NEA:KDBwMEm3JO69VS5?	M{TsblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NkGxO\|cyLz5{M{[xNVc4OTxxYU6=
insect	M1;OTWZ2dmO2aX;uJIF{e2G7		MnPQN\|AhdWmwcx?=	MXzJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KHerbHSgeJlx\SCDQlyxJIV5eHKnc4Pl[EBqdiCrboPlZ5Qh[2WubIOgZYZ1\XJiM{CgcYlveyCkeTDGVmVVKGG\|c3H5MEBKSzVyIE2gNE4xQTh{IN88UU4>	NWrke4FiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
K562	MoTPR5l1d3SxeHnjbZR6KGG\|c3H5		MX:3NkBpenN?	NUWxcJg6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCwMlEh\|ryPLh?=	NUjFR25PRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
primary leukemia cells	NHy3enVEgXSxdH;4bYNqfHliYYPzZZk>		NVTXe2N3PzJiaILz	M2HhOGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJBzcW2jcomgcIV2c2WvaXGgZ4VtdHNiaYPvcIF1\WRiZoLvcUBi[3W2ZTDtfYVtd2mmIHzleYtmdWmjIIDheIlmdnRiZYjwdoV{e2mwZzD3bYxlKHS7cHWgSmxVOyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhdHWlaX\ldoF{\SCjc4PhfUwhUUN3MDC9JFAvOSEQvF2u	NXv2[oRlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNlEzODFpPkKyNlIyOjBzPD;hQi=>
BV173	MXPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		Mo\JOFghcHK\|	MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKYMUezJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCFZXzsMXRqfGW{LVfsc{BtfW2rbnXzZ4VvfCClZXzsJJZq[WKrbHn0fUBie3OjeTygS2k2OCB;IECuNUDPxE1w	Mn;rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUGxOVkoRjJ5MEGxNVU6RC:jPh?=
BAF3	NXXJN2N6TnWwY4Tpc44h[XO\|YYm=		NEPIbmo4OiCqcoO=	MW\Jcohq[mm2aX;uJI9nKFSnbD3meZNm\CClS1nUJGw2PjeSIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvM2NEUzhiYYPzZZktKEeLNUCgQUAxNjFizszNMi=>	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
K562	M1zpVGN6fG:2b4jpZ4l1gSCjc4PhfS=>		MWSyOEBpenN?	NWTYc2wzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5zIN88UU4>	NIrNPWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[zNlk{PSd-MkK2N\|I6OzV:L3G+
BA/F3	NWXNRXlZTnWwY4Tpc44h[XO\|YYm=		M2fEVFczKGi{cx?=	MWnJcohq[mm2aX;uJI9nKFSHTD3meZNm\CCSRFfGVoJmfGFiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W\|ZTDCRU9HOyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxiZ4Lve5RpKGmwY4XiZZRm\CCob4KgO\|IhcHK\|IHL5JG1VWyCjc4PhfUwhT0l3MDC9JFAvOTB{IN88UU4>	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BAF3	Mk\nSpVv[3Srb36gZZN{[Xl?		M4rxRVczKGi{cx?=	Mn;yTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiYz3LTXQhVDV5NmCgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJGJCTjNiY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25ibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONODDhd5NigSxiR1m1NEA:KDBwMUCyJO69VS5?	NYLO[JRHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GIST882	MoSxRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeLU2S4PFIh[2WubIOsJGlEPTBiPTCwMlExQCEQvF2u	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzN{WzPEc,OjB6MUe1N\|g9N2F-
GIST882	NXHPTZJ1TnWwY4Tpc44h[XO\|YYm=			NFnFT2lKdmirYnn0bY9vKG:oIFvJWEBMPjR{RTDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gbJVu[W5iR1nTWFg5OiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KEGWUD3k[ZBt\XSrb36gZZN{[XluIFnDOVAhRSByLkGwPEDPxE1w	NED5XJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xNVc4OSd-MkO2NVE4PzF:L3G+
K562	M2HJ[2N6fG:2b4jpZ4l1gSCjc4PhfS=>			M1nkSGN6fG:2b4jpZ{Bm\m[nY4SgbY4hUzV4MjDj[YxteyxiSVO1NEA:KDBwMUGg{txONg>?	M4XV[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OUWxNVE{Lz5zMkm1NVEyOzxxYU6=
KU812	MX7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MnO1O\|IhcHK\|	Ml7iRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNVUixNkBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzsJJRqfGW{LXfsc{Bie3OjeTygS2k2OCB;IECuNVEh\|ryPLh?=	MmO4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
BA/F3	MkLvRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M3fabFczKGi{cx?=	MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy\|IHX4dJJme3OrbnegRoNzNUGkbDDIN\|k3WCCvdYThcpQh[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOC5zMTFOwG0v	Mny4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ\|MEi4OlQ1RC:jPh?=
BAF3	NUXzcmtwTnWwY4Tpc44h[XO\|YYm=		NF[4SFc4OiCqcoO=	M1HRVWlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIFPTSlFTKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44hdWWjc4Xy[YQh[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMQCCjc4PhfUwhT0l3MDC9JFAvOTFizszNMi=>	NUDwPXZxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
32D	MkHGRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M3XKVlQ5KGi{cx?=	M{Tq[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViM{LEJINmdGy\|IITyZY5{\mWldHXkJJdqfGhicEKxNEBk\WyuczDlfJBz\XO\|aX7nJGJkei2jYnygZZN{\XO\|ZXSgZZMheHKxbHnm[ZJifGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMD6xNVIh\|ryPLh?=	MnzDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2MUW4OlMoRjF4NEG1PFY{RC:jPh?=
insect cells	MYLGeY5kfGmxbjDhd5NigQ>?		M4jIV\|MxKG2rboO=	Mnr3TY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCDQlyxJG0{PTGWIH31eIFvfCCneIDy[ZN{\WRiaX6gbY5{\WO2IHPlcIx{KGGodHXyJFMxKG2rboOgZpkhTlKHVDDhd5NigSxiSVO1NEA:KDBwMUG0N{DPxE1w	NFTSU3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
insect cells	M2TU[mZ2dmO2aX;uJIF{e2G7		NWfXVmtFOzBibXnudy=>	M1qz[WlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiQVLMNUBSOjV{SDDteZRidnRiZYjwdoV{e2WmIHnuJIlve2WldDDj[YxteyCjZoTldkA{OCCvaX7zJIJ6KE[URWSgZZN{[XluIFnDOVAhRSByLkGxOUDPxE1w	NELj[pE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
K562	NYLOdpVSSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NXPxPYFJPzJiaILz	NEmyfXRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGJEWi2DQlyg[IVx\W6mZX70JIh2dWGwIFu1OlIh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT\|gh[XO\|YYmsJGdKPTBiPTCwMlEzKM7:TT6=	MnrGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
BA/F3	M{fpNGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		Mn7CO\|IhcHK\|	NV;NdVgxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhVTJ2NG[gcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IECuNVI6KM7:TT6=	NFHlSWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C4PFY1PCd-MkOwPFg3PDR:L3G+
K562	MlTuRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MVq3NkBpenN?	NWXWTXl4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG\|c3H5MEBIUTVyIE2gNE4yPCEQvF2u	NIK2d4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
HEK293	Ml\1SpVv[3Srb36gZZN{[Xl?			NGmyUGJKdmirYnn0bY9vKG:oIHH1eI9xcG:\|cHjvdplt[XSrb36gc4YhTESUMjDlfJBz\XO\|ZXSgbY4hUEWNMkmzJINmdGy\|IHL5JGVNUVODLDDJR\|UxKD1iMD6xOFEh\|ryPLh?=	NITXNno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO\|U{QCd-MkC4NVc2Ozh:L3G+
K562	NHrkZ3JCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MVy3NkBpenN?	MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkh[2WubDD0bZRmei2pbH:gZZN{[XluIFfJOVAhRSByLkG0O{DPxE1w	NVG3cYtkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1OFE3QTVpPkK4OVQyPjl3PD;hQi=>
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K562	MlTsRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MnjHO\|IhcHK\|	NX3NW3JWSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKEKlcj3BZowh[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOC5{ODFOwG0v	Mn;jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzOUWxN\|YoRjJ4MUm1NVM3RC:jPh?=
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K562	MmDBRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NIXNSpc4OiCqcoO=	NH\6R2VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKHO3co\peoFtKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjN6IN88UU4>	NHrKUlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nki1NFAxPCd-Mk[4OVAxODR:L3G+
BA/F3	M4XOdGZ2dmO2aX;uJIF{e2G7		MXq3NkBpenN?	NFrUS4FKdmirYnn0bY9vKG:oIFLDVk9CSkxicEKxNEApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1utPEBie3OjeTygS2k2OCB;IECuN\|gh\|ryPLh?=	NYfsTWo5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3PFk2PTNpPkK2O\|g6PTV\|PD;hQi=>
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K562	MVvDfZRwfG:6aXPpeJkh[XO\|YYm=		NEHCTFk4OiCqcoO=	NXLEfohnS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCJSUWwJF0hOC5\|OTFOwG0v	M4DtelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUOyN\|E{Lz5{MkmzNlMyOzxxYU6=
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BA/F3	M{jZWWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M2nYVlczKGi{cx?=	M1SxVGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW\|c3nu[{BD[3JvQXLsJG0{PTGWIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSByLkSyOEDPxE1w	NXzSbWpqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
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Sf9	NFnhOoZHfW6ldHnvckBie3OjeR?=			M4XzdGlvcGmkaYTpc44hd2ZiaIXtZY4hSWKuIHvpcoF{\SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzMEBKSzVyIE2gNE41PyEQvF2u	M{PkOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{e2OlgxLz5zN{O3OlY5ODxxYU6=
K562	MlHzR5l1d3SxeHnjbZR6KGG\|c3H5		M1j0dVQ5KGi{cx?=	MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjR5IN88UU4>	NG[ydnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ezOVgzPid-MkO3N\|U5OjZ:L3G+
K562	NGSx[HlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M4XxUVQ5KGi{cx?=	NHO3cHRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuOFch\|ryPLh?=	MnuxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5N{i3OlYoRjJ3N{e4O\|Y3RC:jPh?=
K562	NX;1d4xNTnWwY4Tpc44h[XO\|YYm=			MmizTY5pcWKrdHnvckBw\iCEQ2KtRWJNOSCjdYTvdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIFu1OlIh[2WubIOsJGlEPTBiPTCwMlQ4OyEQvF2u	NVXzU49WRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
insect cells	M3PzNWZ2dmO2aX;uJIF{e2G7		NUHTN4ZNOzBibXnudy=>	NGHwbGFKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFHCUFEhTTJ3NVugcZV1[W62IHX4dJJme3OnZDDpckBqdnOnY4SgZ4VtdHNiYX\0[ZIhOzBibXnud{BjgSCIUlXUJIF{e2G7LDDJR\|UxKD1iMD60PFU5KM7:TT6=	Ml7GQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|MEG3NFMoRjJ\|M{CxO\|A{RC:jPh?=
Sf9	M{LRSWZ2dmO2aX;uJIF{e2G7			NHPodnRDcW6maX7nJIFn\mmwaYT5JJRwKGi3bXHuJJJmdW:2ZTDzbZRmKG:oIF6teIVzdWmwYXygbIV5[Wirc4Tp[Ilv\S22YXfn[YQhSUKOMjDlfJBz\XO\|ZXSgbY4hXHKrY3jvdIx2e2mjIH7pJIlv\mWldHXkJHNnQSClZXzsd{BjgSCrc3;0bIVzdWGuIITpeJJifGmxbjDjZYxwemmvZYTybYMh[XO\|YYmsJGtlKD1iMD61JO69VS5?	M4jHOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEG3N\|Q{Lz5{MUSxO\|M1OzxxYU6=
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K562	MnjiRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			M3fmeWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczygTWM2OCB;IECuOUDPxE1w	M3fSU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{WyOFg{Lz5{M{O1NlQ5OzxxYU6=
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K562	Mo\aR5l1d3SxeHnjbZR6KGG\|c3H5			MWHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzMEBKSzVyIE2gNE42KM7:TT6=	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF6OU[3OEc,OjdzOEm2O\|Q9N2F-
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K562	M4Kxc2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		M2HYRVQ5KGi{cx?=	MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwNTFOwG0v	MmTFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7M{KwO\|EoRjJ\|OUOyNFcyRC:jPh?=
Sf9	MVfGeY5kfGmxbjDhd5NigQ>?			MXnUVH9VWkGQU2DPVnRGWjpiaX7obYJqfGmxbjDv[kBCXFCjc3WgZYN1cX[rdImgbY4hSkOUUD3lfJBz\XO\|aX7nJHNnQSClZXzsd{whUUN3MDC9JFAvPSEQvF2u	M2\Vb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MUW1PFQyLz5zNUG1OVg1OTxxYU6=
K562	MWTDfZRwfG:6aXPpeJkh[XO\|YYm=		Mkm3O\|IhcHK\|	MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCwMlUyKM7:TT6=	M2TNSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OEG0PFkxLz5{NkixOFg6ODxxYU6=
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IMR-5	NUjlZphQT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			M1;z[mlvcGmkaYTpc44hd2ZiaIXtZY4hUU2ULUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFYvOjJzNEeg{txONg>?	NEO2W2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
LB2241-RCC	M4XWXWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			M3fGTWlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ{MkSxMXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iOD6wO\|M5PCEQvF2u	M2XqSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
TGBC24TKB	NYPXflkxT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			MVjJcohq[mm2aX;uJI9nKGi3bXHuJHRISkN{NGTLRkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hQC5\|NEC1NkDPxE1w	M3jEeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
SCC-15	M2K2UWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			MVrJcohq[mm2aX;uJI9nKGi3bXHuJHNESy1zNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gNVAvPzd6ODFOwG0v	NHnUTGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
BB49-HNC	NFTiZ3VIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NEHKXolKdmirYnn0bY9vKG:oIHj1cYFvKEKENEmtTG5EKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSBzND6zN\|M2KM7:TT6=	M4rM[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
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LB2518-MEL	M3PQVmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			M1K1d2lvcGmkaYTpc44hd2ZiaIXtZY4hVEJ{NUG4MW1GVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMU[uOlA6PCEQvF2u	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
NCI-H510A	M{PCRWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			MnjuTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWxNGEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF5LkK0OFIh\|ryPLh?=	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
TE-441-T	MVTHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NXz3R4xxUW6qaXLpeIlwdiCxZjDoeY1idiCWRT20OFEuXCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMUeuNlg5PiEQvF2u	M{K2bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
HH	NH3jW3ZIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			M3fLU2lvcGmkaYTpc44hd2ZiaIXtZY4hUEhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEG3MlM6QTlizszNMi=>	NX;1eXdERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
LC4-1	MXjHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NHfFempKdmirYnn0bY9vKG:oIHj1cYFvKEyFND2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAyQC5yNkWyJO69VS5?	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
KARPAS-45	MULHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NX3WVFQ{UW6qaXLpeIlwdiCxZjDoeY1idiCNQWLQRXMuPDViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEG4MlE5PDhizszNMi=>	NFjsdGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
LB1047-RCC	Mn7VS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NWXwenFyUW6qaXLpeIlwdiCxZjDoeY1idiCOQkGwOFcuWkOFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCxPE41PDV{IN88UU4>	NVixfm45RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
NKM-1	M2PIemdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			M1rTRWlvcGmkaYTpc44hd2ZiaIXtZY4hVkuPLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFE6NjN3NUKg{txONg>?	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
SCLC-21H	NInyRm5Iem:5dHigTY5pcWKrdHnvckBie3OjeR?=			MW\Jcohq[mm2aX;uJI9nKGi3bXHuJHNEVENvMkHIJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzOC5zMkS2JO69VS5?	NV7Oe3N6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
RS4-11	MUDHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NV2ye5RLUW6qaXLpeIlwdiCxZjDoeY1idiCUU{StNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDJyLkOzNFgh\|ryPLh?=	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
ALL-PO	NFHzcWlIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			M4\PSmlvcGmkaYTpc44hd2ZiaIXtZY4hSUyOLWDPJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzOC56MUS5JO69VS5?	NWrEc3dTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
GDM-1	M4nkV2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NVmzWFJnUW6qaXLpeIlwdiCxZjDoeY1idiCJRF2tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOjJwNUm0OUDPxE1w	MnPGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
DMS-79	NHjBfGdIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NY\4Xm5SUW6qaXLpeIlwdiCxZjDoeY1idiCGTWOtO\|kh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDJ2LkS5N\|Qh\|ryPLh?=	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
MPP-89	MlLRS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NIHrNHRKdmirYnn0bY9vKG:oIHj1cYFvKE2SUD24PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOjVwNki3OEDPxE1w	MoTSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
NB10	NF3YOZFIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			MoLSTY5pcWKrdHnvckBw\iCqdX3hckBPSjFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCyOk41PyEQvF2u	MmLmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
LS-513	NITCVWZIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			Mn6xTY5pcWKrdHnvckBw\iCqdX3hckBNWy13MUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFI3Njh6NEeg{txONg>?	NYrVT21yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
L-540	MULHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			MYfJcohq[mm2aX;uJI9nKGi3bXHuJGwuPTRyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCyOk46OTR\|IN88UU4>	M{fMcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
ES1	NWnSZlVjT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			MlflTY5pcWKrdHnvckBw\iCqdX3hckBGWzFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEK3MlUzOSEQvF2u	M3XlfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
NTERA-S-cl-D1	M4Xjd2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7			MX\Jcohq[mm2aX;uJI9nKGi3bXHuJG5VTVKDLWOtZ4wuTDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEOwMlUxQTNizszNMi=>	M3rmbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
EW-1	M37qcWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			MXTJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEOyMlk1PTRizszNMi=>	MnG4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
Calu-6	M2TPc2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NXnLWGhvUW6qaXLpeIlwdiCxZjDoeY1idiCFYXz1MVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDN\|LkG4OVUh\|ryPLh?=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
CTV-1	M1L0ZWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NFzRXGtKdmirYnn0bY9vKG:oIHj1cYFvKEOWVj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA{Oy57N{i5JO69VS5?	NG\Dcok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
YT	MXzHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			Ml\zTY5pcWKrdHnvckBw\iCqdX3hckB[XCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iM{iuOVIxQSEQvF2u	M33DflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
TE-6	NI[0UpBIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NVzrZVBIUW6qaXLpeIlwdiCxZjDoeY1idiCWRT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1OS5{N{m3JO69VS5?	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
HT-144	Mnu0S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			Mlr3TY5pcWKrdHnvckBw\iCqdX3hckBJXC1zNESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQyNjV2OE[g{txONg>?	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
EW-13	MorYS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			MVLJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTF\|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTC0Nk4zPzlzIN88UU4>	M4CxTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
KALS-1	MkHaS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			Mn75TY5pcWKrdHnvckBw\iCqdX3hckBMSUyVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ{NjF\|Mkig{txONg>?	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
MOLT-16	NEjG[I5Iem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NYjBVYZrUW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVE3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB2NT6wO\|UzKM7:TT6=	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
D-336MG	M1nkOGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NUnpeG1ZUW6qaXLpeIlwdiCxZjDoeY1idiCGLUOzOm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB2NT65OVk6KM7:TT6=	M4S2T\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
TE-11	M4jVXmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			M{PrN2lvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ3NjZ3MzFOwG0v	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
EB2	NV7HS4hsT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			NE\XTY5KdmirYnn0bY9vKG:oIHj1cYFvKEWEMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gOFYvPjl7IN88UU4>	NFvUN3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
SK-N-DZ	M{\kW2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7			Mo\jTY5pcWKrdHnvckBw\iCqdX3hckBUUy2QLVTaJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1QC5yOU[xJO69VS5?	NF;mTIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
SW684	MoXTS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			MXjJcohq[mm2aX;uJI9nKGi3bXHuJHNYPjh2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTC0PE4zPjl3IN88UU4>	MnS1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
EW-18	MVvHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			M{TB[2lvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ5NjR\|OUWg{txONg>?	M1zqUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-ZAP70 / ZAP70 / p-LAT / LAT; PubMed: 18981115 J Immunol For the analysis of imatinib interference with early TCR signaling events, cells were activated for 5 min with anti-CD3 and anti-CD28 Abs and blots were probed with anti-phospho ZAP70, anti-ZAP70, anti-phospho LAT or anti-LAT antibodies. Untreated, non-ac䲧疝Ỵ疞㧀疜膉痘瘿�෋ᾰƌ෋à p-STAT3 / STAT3 / p-STAT5 / STAT5; PubMed: 18981115 J Immunol For phospho-STAT3 and Phospho-STAT5 detection, cells were then activated for 6 hrs with anti-CD3 and anti-CD28 Ab. Equivalent amounts of protein from cell lysates were separated by SDS-PAGE and western blot analysis was then performed using anti-phospho S䲧疝Ỵ疞㧀疜膉痘瘿뙠ෆᾰƌෆĀ㺣痖帉痖	18981115
Immunofluorescence	Cortactin / F-actin; PubMed: 20937825 J Biol Chem NIH3T3-SrcY527F cells were treated with DMSO or with 10 μm STI571 for 16 h, fixed and co-stained for cortactin (red, left panels) and F-actin (green, middle panels). Merged fields (right panels) demonstrate co-localization between cortactin and F-actin at䲧疝Ỵ疞㧀疜 RelB; PubMed: 20371728 Mol Cancer Ther Nuclear proteins were extracted from the untreated and treated cells and nuclear levels of RelA and RelB were confirmed by immunocytochemistry	20937825 20371728
Growth inhibition assay	Cell viability ; PubMed: 28435223 Drug Des Devel Ther (C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. 䲧疝Ỵ疞㧀疜膉痘瘿�෋ᾰƌ෋à㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺	28435223

体内研究

Imatinib抑制从新鲜的人小细胞肺癌外科样品来源的SCLC6，SCLC61和SCLC108异种移植肿瘤，抑制率分别是80％，40％和78％，且对SCLC74生长长无显著抑制。^[5] 在高脂肪喂养的ApoE（-/-）小鼠中，通过管饲法给药10 mg/kg，20 mg/kg和40 mg/kg Imatinib，和对照组相比高脂诱导的脂质染色区域减少了30％，27％和35％，并且颈动脉脂质积聚得到抑制。^[6]

激酶实验：^[1]	- 合并 PDGF受体激酶活性 : PDGF受体是由BALB / c3T3细胞提取物免疫共沉淀所得，通过兔抗PDGF受体冰上处理2小时所得。蛋白A-琼脂糖珠被用于收集抗原-抗体复合物。免疫沉淀物用TNET（50 mM Tris，pH 7.5，140 mM氯化钠，5mM的EDTA，1％的Triton X-100）洗涤两次，用TNE（50 mM Tris，pH 7.5，140 mM EDTA）洗涤一次，并用激酶缓冲液（20 mM的Tris，pH 7.5, 10 mM氯化镁）洗涤一次。用PDGF（50 ng/mL）在4℃下刺激10分钟后，不同浓度的药物加入到反应混合物中。PDGF受体激酶活性是通过温浴10 μCi [³³P]-ATP和l μM ATP 10分钟来确定。免疫复合物经SDS-PAGE上的7.5％凝胶上分离。
细胞实验：^[3]	- 合并 Cell lines: BON-1 和 NCI-H727细胞 Concentrations: 约100 μM Incubation Time: 48小时 Method: BON-1细胞和NCI-H727细胞接种到平底96孔板中三个复孔，并在含10％胎牛血清的DMEM或RPMI1640完全培养基中贴壁过夜，然后更换为血清培养基（阴性对照）或含不同浓度梯度Imatinib的无血清培养基。48小时（对照培养物没有达到汇合）后，代谢活性细胞的数量是由3-（4,5-二甲基吡啶-2-基）-2,5-二苯基溴化测定，由帕卡德光谱酶标仪测定540nm处吸光度。生长抑制通过以下公式计算：抑制率=(1 − a / b) × 100%，其中a和b分别是治疗组和对照组的吸光度值。 (Only for Reference)
动物实验：^[5]	- 合并 Animal Models: SCLC6, SCLC61, SCLC 74 and SCLC108 小细胞肺癌注入瑞士小鼠 (nu/nu, 雌性）。 Dosages: 70或100 mg/kg Administration: 腹腔注射 (Only for Reference)

参考文献

- 合并

溶解度 (25°C)

体外	DMSO	118 mg/mL (200.09 mM)
	Water	118 mg/mL (200.09 mM)
	Ethanol	Insoluble

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Imatinib (STI571) Mesylate SDF

分子量	589.71
化学式	C₂₉H₃₁N₇O.CH₄SO₃
CAS号	220127-57-1
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	Gleevec, Glivec, CGP-57148B

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2022-01-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02687425	Unknown status	Drug: Pioglitazone\|Drug: imatinib mesylate	Leukemia Myelogenous Chronic BCR-ABL Positive	Meng Li\|Tongji Hospital	February 2016	Phase 2
NCT02303899	Completed	Drug: Gemcitabine\|Drug: Imatinib mesylate	Mesothelioma Malignant	Istituto Clinico Humanitas	November 2014	Phase 2
NCT01898377	Terminated	Drug: Imatinib mesylate Mycophenolate mofetil	Chronic Graft-versus-host Disease	Seoul National University Hospital	August 2013	Phase 2
NCT02891395	Completed	Drug: Imatinib Mesylate and Nilotinib	Graft Versus Host Disease	University Hospital Lille\|Novartis	December 24 2012	Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

选择性强的Bcr-Abl抑制剂

Nilotinib (AMN-107) : Bcr-Abl-selective, IC50<30 nM.
活性最高的Bcr-Abl抑制剂

GZD824 : Bcr-Abl(WT), IC50=0.34 nM; Bcr-Abl(T315I), IC50=0.68 nM.
FDA批准的Bcr-Abl抑制剂

Dasatinib : Approved by FDA for CML and Ph+ ALL.
最新的Bcr-Abl抑制剂

GZD824 : Orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

研究领域

产品类型

定制您的化合物库

Imatinib (STI571) Mesylate

客户使用Selleck生产的Imatinib (STI571) Mesylate发表文献198篇：

产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Imatinib (STI571) Mesylate SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2022-01-17)

技术支持

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

相关Bcr-Abl产品