Imatinib (STI571) Mesylate

For research use only. Not for use in humans.

目录号：S1026 别名： Gleevec, Glivec, CGP-57148B 中文名称：甲磺酸伊马替尼

Imatinib (STI571) Mesylate Chemical Structure

CAS No. 220127-57-1

Imatinib Mesylate (STI571, CGP-57148B)是一种口服生物有效的Imatinib甲磺酸盐，是一种多靶点抑制剂，作用于v-Abl，c-Kit和PDGFR，在无细胞和细胞试验中，IC50分别为0.6 μM，0.1 μM 和0.1 μM。Imatinib Mesylate (STI571) 可诱导自噬。

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10mM (1mL in DMSO)	RMB 1567.38	现货
100mg	RMB 780.01	现货
250mg	RMB 1603.82	现货
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客户使用Selleck生产的Imatinib (STI571) Mesylate发表文献180篇：

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产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

产品描述

靶点

PDGFR ^[1] (Cell-free assay)	c-Kit ^[2] (M-07e cells)	v-Abl ^[1] (Cell-free assay)
100 nM	100 nM	600 nM

体外研究

抑制酪氨酸和丝氨酸/苏氨酸蛋白激酶的体外测定法显示Imatinib有效抑制V-Abl酪氨酸激酶和PDGFR，IC50分别为0.6 μM和0.1 μM。^[1] Imatinib抑制SLF-依赖性激活的野生型的c-kit激酶活性，IC 50约为0.1 μM，这类似抑制PDGFR所需的浓度。^[2] Imatinib表现出对人支气管类癌细胞系NCI-H727和人胰腺类癌细胞系BON-1的抑制作用，IC50分别为32.4 μM和32.8 μM。 ^[3] 最近的一项研究显示，Imatinib通过下调hERG1 K(+)通道发挥在慢性粒细胞白血病的抗白血病作用，hERG1 K(+)通道在白血病细胞中高表达并表现有利于白血病出现。^[4]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
GIST882	NVLLdJZHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NHvmbG06PiCq	MkLwTWM2OD1zLkeg{txO	M370VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUCwNlEzLz5{NEmwNFIyOjxxYU6=
K562	MnPaR5l1d3SxeHnjbZR6KEG\|c3H5		NVT5bWNyOjRiaB?=	MXjJR\|UxRTBwMkGg{txO	NYrYU5JZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNFAzODdpPkKyNFAxOjB5PD;hQi=>
MCF-7	M4HnXWN6fG:2b4jpZ4l1gSCDc4PhfS=>		MV2yOEBp	MX\JR\|UxRTBwOEOg{txO	NGjCWmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkCwNFIxPyd-MkKwNFAzODd:L3G+
MDA-MB-23	NGnDT\|VEgXSxdH;4bYNqfHliQYPzZZk>		NHzvTHozPCCq	MnLaTWM2OD1zLkig{txO	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjByMEKwO{c,OjJyMECyNFc9N2F-
K562r	NUWzVFJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MXnJR\|UxRTFywrFOwG0>	MnL6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7M{m0NVgoRjJ2OUO5OFE5RC:jPh?=
K562	MornS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			Ml\USWM2OD1yLkC5JO69VQ>?	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjZ5OESxOEc,OTZ4N{i0NVQ9N2F-
MCF-7	Mn3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYD4dHU{OTBizszN	MWW0PEBp	NIjwWpBjdG:la4OgZ4VtdCCycn;sbYZmemG2aX;uJIlv[3KnYYPlJIlv\HWlZXSgZpkhSkp\|Wh?=	M376dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mke0NFM1Lz5{NUK3OFA{PDxxYU6=
K-562	Mn3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M2TBfGlEPTB;MTFOwG0>	M3;2blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MkO5OlYzLz5{NUKzPVY3OjxxYU6=
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Ba/F3	M2Xv[2Z2dmO2aX;uJIF{e2G7		NXLNWXdyPDhiaILz	MYnJcohq[mm2aX;uJI9nKHerbHSgeJlx\SCEQ2KtRWJNOSBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEYT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB2ODDodpMh[nliQoLpeIVNcWeqdDDseYNq\mW{YYPlJIF{e2G7LDDHTVUxKD1iMD6wPVA2KM7:TT6=	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF\|N{m4NUc,OzBzM{e5PFE9N2F-
BA/F3	M3PwNmN6fG:2b4jpZ4l1gSCjc4PhfS=>		MnzYOFghcHK\|	M3;ZfGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z\|IHPlcIx{KHS{YX7z[oVkfGWmIIfpeIghf2muZDD0fZBmKEKlcj3BZowh[W[2ZYKgOFghcHK\|IHL5JHhVXCCjc4PhfUwhUUN3MDC9JFAvODl{IN88UU4>	NIfQV3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNFgxPid-MkO2NFA5ODZ:L3G+
GIST882	NHXueW5HfW6ldHnvckBie3OjeR?=			M3fLe2lvcGmkaYTpc44hd2ZiaIXtZY4hU0mWIHH1eI9xcG:\|cHjvdplt[XSrb36gbY4hcHWvYX6gS2lUXDh6MjDj[YxteyCkeTDFUGlUSSxiSVO1NEA:KDBwMEm3JO69VS5?	Mm\iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N\|goRjJyOEG3OVM5RC:jPh?=
GIST882	MVfGeY5kfGmxbjDhd5NigQ>?			Mn3zTY5pcWKrdHnvckBw\iCNSWSgT\|Y1OkVibYX0ZY51KGG3dH;wbI9{eGixconsZZRqd25iKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gbJVu[W5iR1nTWFg5OiClZXzsd{BjgSCHTFnTRUwhUUN3MDC9JFAvODl5IN88UU4>	MlPVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUG3O\|EoRjJ\|NkGxO\|cyRC:jPh?=
insect	M2\RV2Z2dmO2aX;uJIF{e2G7		NWXvS5d4OzBibXnudy=>	MljQTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCC5aXzkJJR6eGViQVLMNUBmgHC{ZYPz[YQhcW5iaX7z[YN1KGOnbHzzJIFnfGW{IEOwJI1qdnNiYomgSnJGXCCjc4PhfUwhUUN3MDC9JFAvODl6MjFOwG0v	NWe4S3IyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
K562	MXvDfZRwfG:6aXPpeJkh[XO\|YYm=		NYDoZnpIPzJiaILz	M33xd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMD6xJO69VS5?	NWj3ZWJiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
primary leukemia cells	NHTVe4dEgXSxdH;4bYNqfHliYYPzZZk>		M3e3V\|czKGi{cx?=	NFHpOppEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBxemmvYYL5JIxmfWunbXnhJINmdGy\|IHnzc4xifGWmIH\yc40h[WO3dHWgcZlmdG:rZDDs[ZVs\W2rYTDwZZRq\W62IHX4dJJme3Orbnege4lt\CC2eYDlJGZNXDNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGy3Y3nm[ZJie2ViYYPzZZktKEmFNUCgQUAxNjFizszNMi=>	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ{MUKwNUc,OjJ{MkGyNFE9N2F-
BV173	NFz2PGdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MVu0PEBpenN?	M1fERmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQm[xO\|Mh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IFPlcIwuXGm2ZYKtS4xwKGy3bXnu[ZNk\W62IHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBIUTVyIE2gNE4yKM7:TT6=	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzMUG1PUc,OjdyMUGxOVk9N2F-
BAF3	NX6wO3NTTnWwY4Tpc44h[XO\|YYm=		M4WzOFczKGi{cx?=	MlG2TY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEBNPTZ5UDDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W\|ZTDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{9ES0t6IHHzd4F6NCCJSUWwJF0hOC5zIN88UU4>	MlTpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
K562	Mnn5R5l1d3SxeHnjbZR6KGG\|c3H5		M2Kyc\|I1KGi{cx?=	M3v3T2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgNlQhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOSEQvF2u	NXrQcnd6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2N\|I6OzVpPkKyOlMzQTN3PD;hQi=>
BA/F3	M{jPZ2Z2dmO2aX;uJIF{e2G7		MnXSO\|IhcHK\|	Mom1TY5pcWKrdHnvckBw\iCWRVyt[pV{\WRiUFTHSnJj\XSjIDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmEwTjNiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFNiYYPzZZktKEeLNUCgQUAxNjFyMjFOwG0v	NWrkPJVnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BAF3	MlrJSpVv[3Srb36gZZN{[Xl?		MkGzO\|IhcHK\|	MVfJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClLVvJWEBNPTd4UDDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0t6IHHzd4F6NCCJSUWwJF0hOC5zMEKg{txONg>?	NXjmW2QzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GIST882	NHTxWWJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			NY\ITYxlSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHTXNVQDh{IHPlcIx{NCCLQ{WwJF0hOC5zMEig{txONg>?	MnvaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N\|goRjJyOEG3OVM5RC:jPh?=
GIST882	Mny1SpVv[3Srb36gZZN{[Xl?			NEXp[JJKdmirYnn0bY9vKG:oIFvJWEBMPjR{RTDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gbJVu[W5iR1nTWFg5OiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KEGWUD3k[ZBt\XSrb36gZZN{[XluIFnDOVAhRSByLkGwPEDPxE1w	M2K3NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NkGxO\|cyLz5{M{[xNVc4OTxxYU6=
K562	M3TlSmN6fG:2b4jpZ4l1gSCjc4PhfS=>			NFGzT\|lEgXSxdH;4bYMh\W[oZXP0JIlvKEt3NkKgZ4VtdHNuIFnDOVAhRSByLkGxJO69VS5?	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjl3MUGxN{c,OTJ7NUGxNVM9N2F-
KU812	NXO4b5RKSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MVG3NkBpenN?	NF7mVlFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFvVPFEzKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG\|c3H5MEBIUTVyIE2gNE4yOSEQvF2u	Ml7JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
BA/F3	NEDjVYFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NHW1NJU4OiCqcoO=	MonuRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDtc5V{\SCEQT;GN{Bk\WyuczDlfJBz\XO\|aX7nJGJkei2DYnygTFM6PlBibYX0ZY51KGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDBwMUGg{txONg>?	NHGweJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C4PFY1PCd-MkOwPFg3PDR:L3G+
BAF3	MYXGeY5kfGmxbjDhd5NigQ>?		M2rYSFczKGi{cx?=	NW\zbHV4UW6qaXLpeIlwdiCxZjDU[Ywu\nW\|ZXSgR3NHOVJiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0t6IHHzd4F6NCCJSUWwJF0hOC5zMTFOwG0v	MnnGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
32D	NFHZXoJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MnO4OFghcHK\|	MVPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKDN{RDDj[YxteyC2cnHud4Zm[3SnZDD3bZRpKHB{MUCgZ4VtdHNiZYjwdoV{e2mwZzDCZ5Iu[WKuIHHzd4V{e2WmIHHzJJBzd2yrZnXyZZRqd25iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMUGyJO69VS5?	M3mxdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
insect cells	M3\YeGZ2dmO2aX;uJIF{e2G7		M3f0bFMxKG2rboO=	MV\Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEGETEGgUVM2OVRibYX0ZY51KGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMh[W[2ZYKgN\|AhdWmwczDifUBHWkWWIHHzd4F6NCCLQ{WwJF0hOC5zMUSzJO69VS5?	NE\QSWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
insect cells	MnfaSpVv[3Srb36gZZN{[Xl?		MYSzNEBucW6\|	M1:ydWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiQVLMNUBSOjV{SDDteZRidnRiZYjwdoV{e2WmIHnuJIlve2WldDDj[YxteyCjZoTldkA{OCCvaX7zJIJ6KE[URWSgZZN{[XluIFnDOVAhRSByLkGxOUDPxE1w	NISxbnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
K562	MkX4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M3;LbVczKGi{cx?=	M{THc2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgRmNTNUGETDDk[ZBmdmSnboSgbJVu[W5iS{W2NkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JINmdGy2aYTldk1odG9xQ1PLPEBie3OjeTygS2k2OCB;IECuNVIh\|ryPLh?=	M4S5dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O\|A2Lz5{N{C3O\|cxPTxxYU6=
BA/F3	NV;W[lBxSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NEXkd3Y4OiCqcoO=	NEi0[oRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LVHicEBOOjR2VjDteZRidnRiYX\0[ZIhPzJiaILzJIJ6KEOFSz24JIF{e2G7LDDJR\|UxKD1iMD6xNlkh\|ryPLh?=	MoGxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ\|MEi4OlQ1RC:jPh?=
K562	MWLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NX7VXYczPzJiaILz	NVuybHlrSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG\|c3H5MEBIUTVyIE2gNE4yPCEQvF2u	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
HEK293	MXLGeY5kfGmxbjDhd5NigQ>?			M1rlb2lvcGmkaYTpc44hd2ZiYYX0c5Bpd3OyaH;yfYxifGmxbjDv[kBFTFJ{IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYomgSWxKW0FuIFnDOVAhRSByLkG0NUDPxE1w	Mn3BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N\|goRjJyOEG3OVM5RC:jPh?=
K562	M4PxPWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NVXYVVlqPzJiaILz	M3TrbmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzsJJRqfGW{LXfsc{Bie3OjeTygS2k2OCB;IECuNVQ4KM7:TT6=	Ml2wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
BAF3	M2LVcGZ2dmO2aX;uJIF{e2G7		MV:3NkBpenN?	NETGb\|ZKdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDjT2lVKEF6MknQJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W\|ZTDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG\|c3H5MEBIUTVyIE2gNE4yPDh{IN88UU4>	NFf0WJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
Ba/F3	NG\0UoJHfW6ldHnvckBie3OjeR?=		MormOFghcHK\|	NEXNbYNKdmirYnn0bY9vKG:oIFLDVk1CSkxzIFWzOVVIKG23dHHueEApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCvb4Xz[UBD[S:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEKFUj3BRmwyNW2nZHnheIVlKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkA1QCCqcoOgZpkhSnKrdHXMbYdpfCCudXPp[oVz[XOnIHHzd4F6NCCJSUWwJF0hOC5zNEmg{txONg>?	NV;KOJVrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxN\|c6QDFpPkOwNVM4QThzPD;hQi=>
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KU812	Mne4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MlnEO\|IhcHK\|	MV\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEuXOEGyJINmdGy\|IH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFS{igZZN{[XluIFfJOVAhRSByLkG2N{DPxE1w	NWTSS\|hSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
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K562	NVfteZlUS3m2b4TvfIlkcXS7IHHzd4F6			NFfGZo1EgXSxdH;4bYNqfHliYXfhbY5{fCCNNU[yJINmdGy\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOThizszNMi=>	M1HMblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUeyNFg5Lz5zN{W3NlA5QDxxYU6=
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BA/F3	NHjV[2ZHfW6ldHnvckBie3OjeR?=		NHjLfVc4OiCqcoO=	NV3UO5p1UW6qaXLpeIlwdiCxZjDCR3IwSUKOIICyNVAhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO\|YYmsJGdKPTBiPTCwMlM5KM7:TT6=	MkTHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm1OVMoRjJ4N{i5OVU{RC:jPh?=
BAF3	MUXGeY5kfGmxbjDhd5NigQ>?		MX63NkBpenN?	M4PZUWlvcGmkaYTpc44hd2ZiVFXMMYZ2e2WmIHPLTXQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkGIMzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBk\WyuIITpeIVzNWeubzDhd5NigSxiR1m1NEA:KDBwM{ixPUDPxE1w	NFv6NWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
K562	M2HxfWN6fG:2b4jpZ4l1gSCjc4PhfS=>		MnPLOFghfG9iN{KgbJJ{	NHLvSVdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDS1JvQVLMJJBwe2m2aY\lJGs2PjJiY3XscJMh[W[2ZYKgOFghfG9iN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuN\|g1PCEQvF2u	M2rX[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{i5OFI6Lz5{Mke4PVQzQTxxYU6=
K562	M1ntNGN6fG:2b4jpZ4l1gSCjc4PhfS=>		NIO5PIE4OiCqcoO=	MnLGR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRUKGG\|c3H5MEBIUTVyIE2gNE4{QSEQvF2u	NIPVZXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmzNlMyOyd-MkK5N\|I{OTN:L3G+
BA/F3	MX\GeY5kfGmxbjDhd5NigQ>?		MkLTO\|IhcHK\|	NI[2WpVKdmirYnn0bY9vKG:oIFvpeEBmgG:wIEGxJIRmdGW2aX;uJEg2PTdidH:gOVU5KHKnc3nkeYV{MSCjbnSgWlY2PEFibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO\|YYmsJGdKPTBiPTCwMlM6OiEQvF2u	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BA/F3	M2TPVmFvfGmycn;sbYZmemG2aY\lJIF{e2G7	MkL0OUB1dyBzMDD1US=>	MoXVOFghcHK\|	M1XGfGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW\|c3nu[{BPWE1vYXLsJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIF1KDVidH:gNVAhfU1iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwM{mzJO69VS5?	M2\hWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
K562	NYnkNVduTnWwY4Tpc44h[XO\|YYm=			M3uzd2lvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIdzd3e2aDD1d4lv\yCPVGSgZZN{[XluIFnDOVAhRSByLkSg{txONg>?	NIXOdo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEW1Nlc3OCd-MUS1OVI4PjB:L3G+
BAF3	NVTLSWhxTnWwY4Tpc44h[XO\|YYm=		MnL4O\|IhcHK\|	MkLETY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT\|gh[XO\|YYmsJGdKPTBiPTCwMlQh\|ryPLh?=	M1LDUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O\|A2Lz5{N{C3O\|cxPTxxYU6=
BA/F3	M3LuOmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NF7KRYU4OiCqcoO=	NUDWT2F7SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhVTN3MWSgcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IECuOFI1KM7:TT6=	NVnmWIJORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
KCL22	MorpRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MVi0PEBpenN?	MnLDRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNQ1yyNkBk\WyuczDh[pRmeiB2ODDodpMh[nliQ3XscE1VcXSncj3HcI8hdHWvaX7ld4NmdnRiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGdKPTBiPTCwMlQ{KM7:TT6=	Mn7sQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUGxOVkoRjJ5MEGxNVU6RC:jPh?=
Ba/F3	M1PW[mZ2dmO2aX;uJIF{e2G7		M1PNe\|Q5KGi{cx?=	MX3Jcohq[mm2aX;uJI9nKEKFUj3BRmwyKFF{NULIJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W\|ZTDCZU9HOyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGJEWi2DQlyxMY1m\GmjdHXkJINmdGxicILvcIln\XKjdHnvckBi\nSncjC0PEBpenNiYomgRpJqfGWOaXfoeEBtfWOrZnXyZZNmKGG\|c3H5MEBIUTVyIE2gNE41PTVizszNMi=>	NHqwXZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEGzO\|k5OSd-M{CxN\|c6QDF:L3G+
Sf9	NIC2dXJHfW6ldHnvckBie3OjeR?=			M4Psc2lvcGmkaYTpc44hd2ZiaIXtZY4hSWKuIHvpcoF{\SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzMEBKSzVyIE2gNE41PyEQvF2u	MlfGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd\|N{[2PFAoRjF5M{e2OlgxRC:jPh?=
K562	NXzY[3RFS3m2b4TvfIlkcXS7IHHzd4F6		MnOwOFghcHK\|	Mn;BR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC52NzFOwG0v	NFu1O3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ezOVgzPid-MkO3N\|U5OjZ:L3G+
K562	NI\hdIlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NWXScXhiPDhiaILz	NWPNcos5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCwMlQ4KM7:TT6=	M1vLd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{e4O\|Y3Lz5{NUe3PFc3PjxxYU6=
K562	MWHGeY5kfGmxbjDhd5NigQ>?			NY\QS5pXUW6qaXLpeIlwdiCxZjDCR3IuSUKOMTDheZRweGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJGs2PjJiY3XscJMtKEmFNUCgQUAxNjR5MzFOwG0v	NGPQVHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO\|U{QCd-MkC4NVc2Ozh:L3G+
insect cells	MW\GeY5kfGmxbjDhd5NigQ>?		NWnaT4J5OzBibXnudy=>	NGLnSnFKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFHCUFEhTTJ3NVugcZV1[W62IHX4dJJme3OnZDDpckBqdnOnY4SgZ4VtdHNiYX\0[ZIhOzBibXnud{BjgSCIUlXUJIF{e2G7LDDJR\|UxKD1iMD60PFU5KM7:TT6=	NUPwW\|ZvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
Sf9	MorSSpVv[3Srb36gZZN{[Xl?			M{\UemJqdmSrbnegZYZncW6rdImgeI8hcHWvYX6gdoVud3SnIIPpeIUhd2ZiTj30[ZJucW6jbDDo[ZhicGm\|dHnkbY5mNXSjZ3fl[EBCSkx{IHX4dJJme3OnZDDpckBVemmlaH;wcJV{cWFibnmgbY5n\WO2ZXSgV4Y6KGOnbHzzJIJ6KGm\|b4To[ZJu[WxidHn0doF1cW:wIHPhcI9zcW2ndILpZ{Bie3OjeTygT4QhRSByLkWg{txONg>?	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTRzN{O0N{c,OjF2MUezOFM9N2F-
primary leukemia cells	MnXZR5l1d3SxeHnjbZR6KGG\|c3H5		M2f4OFczKGi{cx?=	MnTZR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdJJqdWG{eTDs[ZVs\W2rYTDj[YxteyCrc3;sZZRm\CCocn;tJIFkfXSnIH35[YxwcWRibHX1b4VucWFicHH0bYVvfCCneIDy[ZN{cW6pIF\MWFMuTDh\|NWmgcZV1[XSrb36gZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IHz1Z4ln\XKjc3WgZZN{[XluIFnDOVAhRSByLkWg{txONg>?	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ{MUKwNUc,OjJ{MkGyNFE9N2F-
BA/F3	NU[5XpZuTnWwY4Tpc44h[XO\|YYm=		NFTQc3U4OiCqcoO=	NWfIUVJ1UW6qaXLpeIlwdiCxZjDUSWwuVEONIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUy16IHHzd4F6NCCJSUWwJF0hOC53IN88UU4>	NH;qTJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
K562	NF3vNHdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			NUnDSIp1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzMEBKSzVyIE2gNE42KM7:TT6=	Mlf3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|NUK0PFMoRjJ\|M{WyOFg{RC:jPh?=
K562	M13xdmN6fG:2b4jpZ4l1gSCjc4PhfS=>		MkLwO\|IhcHK\|	NF\ob4tEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFczKGi{czDifUBk[WylZXnuMWFOKGG\|c3H5MEBKSzVyIE2gNE42KM7:TT6=	MofyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7OEG1N\|IoRjJ\|OUixOVMzRC:jPh?=
K562	NF\RN3JEgXSxdH;4bYNqfHliYYPzZZk>		MmewO\|IhcHK\|	MnHsR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bi\nSncjC3NkBpenNidYPpcochS2GuY3XpckBCVSCkeTDmcJVwemW\|Y3XuZ4Uh[XO\|YYmsJGlEPTBiPTCwMlUh\|ryPLh?=	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd3N{[wN{c,OjV5NUe2NFM9N2F-
K562	MkfnR5l1d3SxeHnjbZR6KGG\|c3H5			M{LFSWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMtKEmFNUCgQUAxNjVizszNMi=>	NF;vUGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{G4PVY4PCd-MkexPFk3PzR:L3G+
BA/F3	NFi3dFZEgXSxdH;4bYNqfHliYYPzZZk>		NWDMe41SPzJiaILz	M1L0d2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z\|IHPlcIx{KGW6cILld5Nqdmdid3ns[EB1gXCnIFLDVk1CSkxiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPDT{05KGG\|c3H5MEBKSzVyIE2gNE42KM7:TT6=	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN\|MEG3NFM9N2F-
K562	M1TobWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M1XPT\|Q5KGi{cx?=	M2iyb2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMD61JO69VS5?	NVz5VGtZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5N\|IxPzFpPkKzPVMzODdzPD;hQi=>
Sf9	MUDGeY5kfGmxbjDhd5NigQ>?			MWnUVH9VWkGQU2DPVnRGWjpiaX7obYJqfGmxbjDv[kBCXFCjc3WgZYN1cX[rdImgbY4hSkOUUD3lfJBz\XO\|aX7nJHNnQSClZXzsd{whUUN3MDC9JFAvPSEQvF2u	NID1UJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUG1OVg1OSd-MUWxOVU5PDF:L3G+
K562	NXLoe5J3S3m2b4TvfIlkcXS7IHHzd4F6		NH\HcHg4OiCqcoO=	NX7xTHc3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC53MTFOwG0v	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjhzNEi5NEc,OjZ6MUS4PVA9N2F-
K562	NEnzRYtEgXSxdH;4bYNqfHliYYPzZZk>		MYi0PEBpenN?	M1y2ZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvPTNizszNMi=>	NHe5SJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkewO\|g1Pid-Mk[3NFc5PDZ:L3G+
K562	M{G4N2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		NInnZXg1QCCqcoO=	MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwNUOg{txONg>?	NV[5fZNHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1NlU5OzhpPkK4OVI2QDN6PD;hQi=>
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BA/F3	M1:wfGZ2dmO2aX;uJIF{e2G7		NX;jeIdQPzJiaILz	NXzsN3dRUW6qaXLpeIlwdiCxZjDQSGdHWmGucHjhJHY2PjGGL1S4OFJXKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMD61Olch\|ryPLh?=	NI\VSJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
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SCC-15	NETKVnZIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NX;VWVc2UW6qaXLpeIlwdiCxZjDoeY1idiCVQ1OtNVUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDFyLke3PFgh\|ryPLh?=	NHnuZ2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
BB49-HNC	MmnzS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			MljRTY5pcWKrdHnvckBw\iCqdX3hckBDSjR7LVjOR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOTRwM{OzOUDPxE1w	M17IRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
ES7	MlPIS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			MmPsTY5pcWKrdHnvckBw\iCqdX3hckBGWzdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEG0Mlc{PzlizszNMi=>	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
LB2518-MEL	NH;5O5lIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			MYDJcohq[mm2aX;uJI9nKGi3bXHuJGxDOjVzOD3NSWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF4Lk[wPVQh\|ryPLh?=	MlrxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
NCI-H510A	NFO4e\|JIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			M1fRTmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NVBCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSBzNz6yOFQzKM7:TT6=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
TE-441-T	NEDJV4NIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			M1jlSmlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvNESxMXQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF5LkK4PFYh\|ryPLh?=	MmjyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
HH	MmT4S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			MoLXTY5pcWKrdHnvckBw\iCqdX3hckBJUCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMUeuN\|k6QSEQvF2u	NHnrdGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
LC4-1	NIfEZ5pIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NYDkUnVWUW6qaXLpeIlwdiCxZjDoeY1idiCOQ{StNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOThwME[1NkDPxE1w	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
KARPAS-45	NEP1TnJIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NIHuN21KdmirYnn0bY9vKG:oIHj1cYFvKEuDUmDBV{01PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMUiuNVg1QCEQvF2u	NX7v[lVERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
LB1047-RCC	M2TtV2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7			MXPJcohq[mm2aX;uJI9nKGi3bXHuJGxDOTB2Nz3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF6LkS0OVIh\|ryPLh?=	NHi0W4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
NKM-1	M3fGcGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NUTPdW9yUW6qaXLpeIlwdiCxZjDoeY1idiCQS12tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOTlwM{W1NkDPxE1w	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
SCLC-21H	NVrnW3R6T3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			NU\sWohkUW6qaXLpeIlwdiCxZjDoeY1idiCVQ1zDMVIyUCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMkCuNVI1PiEQvF2u	MmOwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
RS4-11	MYPHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NWHQeYh{UW6qaXLpeIlwdiCxZjDoeY1idiCUU{StNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDJyLkOzNFgh\|ryPLh?=	M3XhVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
ALL-PO	NIP0PGtIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NVjZcllxUW6qaXLpeIlwdiCxZjDoeY1idiCDTFytVG8h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDJyLkixOFkh\|ryPLh?=	Mon1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
GDM-1	NXXKSVVxT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			NHrtdVBKdmirYnn0bY9vKG:oIHj1cYFvKEeGTT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzOi53OUS1JO69VS5?	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
DMS-79	NFO2SVJIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			MkS1TY5pcWKrdHnvckBw\iCqdX3hckBFVVNvN{mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFI1NjR7M{Sg{txONg>?	NIHRe289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
MPP-89	M{PI[mdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NXXq[WJ{UW6qaXLpeIlwdiCxZjDoeY1idiCPUGCtPFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDJ3Lk[4O\|Qh\|ryPLh?=	M{XMT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
NB10	MlLZS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NEDaRWxKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFI3NjR5IN88UU4>	NFvsSW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
LS-513	MmKwS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NGjocnpKdmirYnn0bY9vKG:oIHj1cYFvKEyVLUWxN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOjZwOEi0O{DPxE1w	MnHLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
L-540	MYrHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			MX\Jcohq[mm2aX;uJI9nKGi3bXHuJGwuPTRyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCyOk46OTR\|IN88UU4>	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
ES1	M4qyVmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NEe0ZXFKdmirYnn0bY9vKG:oIHj1cYFvKEWVMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gNlcvPTJzIN88UU4>	M3HYdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
NTERA-S-cl-D1	NHvpZ\|hIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NGrLZo1KdmirYnn0bY9vKG:oIHj1cYFvKE6WRWLBMXMu[2xvREGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFMxNjVyOUOg{txONg>?	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
EW-1	MnnwS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NWjKZWp[UW6qaXLpeIlwdiCxZjDoeY1idiCHVz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA{Oi57NEW0JO69VS5?	NUfiS2lmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
Calu-6	M2D6bGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			Mm\RTY5pcWKrdHnvckBw\iCqdX3hckBE[Wy3LU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFM{NjF6NUWg{txONg>?	NVvtNZZFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
CTV-1	Mo\WS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			M3TJcmlvcGmkaYTpc44hd2ZiaIXtZY4hS1SYLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFM{Njl5OEmg{txONg>?	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
YT	NESwV3ZIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			M4PJe2lvcGmkaYTpc44hd2ZiaIXtZY4hYVRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEO4MlUzODlizszNMi=>	Mk\BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
TE-6	M2HpXGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			MVrJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IESxMlI4QTdizszNMi=>	MmXpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
HT-144	NXnJdIh[T3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			MnH6TY5pcWKrdHnvckBw\iCqdX3hckBJXC1zNESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQyNjV2OE[g{txONg>?	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
EW-13	MVzHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NHPocnNKdmirYnn0bY9vKG:oIHj1cYFvKEWZLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1Oi5{N{mxJO69VS5?	Mm\vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
KALS-1	M4fGVGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NVfxTY9ZUW6qaXLpeIlwdiCxZjDoeY1idiCNQVzTMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDR\|LkGzNlgh\|ryPLh?=	NFT1R2U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
MOLT-16	NF\LO4VIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			MW\Jcohq[mm2aX;uJI9nKGi3bXHuJG1QVFRvMU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ2NjB5NUKg{txONg>?	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
D-336MG	MYfHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			M1iyOmlvcGmkaYTpc44hd2ZiaIXtZY4hTC1\|M{\NS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDVwOUW5PUDPxE1w	M3;Nc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
TE-11	NY[3eVZsT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			Mn76TY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gOFYvPjV\|IN88UU4>	MknQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
EB2	MV\Hdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NWrDdnFHUW6qaXLpeIlwdiCxZjDoeY1idiCHQkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ3NjZ7OTFOwG0v	NVy3OXBLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
SK-N-DZ	MW\Hdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NXPYSHhZUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3OMWRbKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB2OD6wPVYyKM7:TT6=	Mlj3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
SW684	M2jBWWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NXrNeldLUW6qaXLpeIlwdiCxZjDoeY1idiCVV{[4OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDhwMk[5OUDPxE1w	M3HPOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
EW-18	MlfkS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			MljITY5pcWKrdHnvckBw\iCqdX3hckBGXy1zODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gOFgvPDN7NTFOwG0v	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-STAT3 / STAT3 / p-STAT5 / STAT5; PubMed: 18981115 J Immunol For phospho-STAT3 and Phospho-STAT5 detection, cells were then activated for 6 hrs with anti-CD3 and anti-CD28 Ab. Equivalent amounts of protein from cell lysates were separated by SDS-PAGE and western blot analysis was then performed using anti-phospho S䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖 p-ZAP70 / ZAP70 / p-LAT / LAT; PubMed: 18981115 J Immunol For the analysis of imatinib interference with early TCR signaling events, cells were activated for 5 min with anti-CD3 and anti-CD28 Abs and blots were probed with anti-phospho ZAP70, anti-ZAP70, anti-phospho LAT or anti-LAT antibodies. Untreated, non-ac䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 	18981115
Immunofluorescence	RelB; PubMed: 20371728 Mol Cancer Ther Nuclear proteins were extracted from the untreated and treated cells and nuclear levels of RelA and RelB were confirmed by immunocytochemistry Cortactin / F-actin; PubMed: 20937825 J Biol Chem NIH3T3-SrcY527F cells were treated with DMSO or with 10 μm STI571 for 16 h, fixed and co-stained for cortactin (red, left panels) and F-actin (green, middle panels). Merged fields (right panels) demonstrate co-localization between cortactin and F-actin at䲧疝Ỵ疞㧀疜	20371728 20937825
Growth inhibition assay	Cell viability ; PubMed: 28435223 Drug Des Devel Ther (C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. 䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺	28435223

体内研究

Imatinib抑制从新鲜的人小细胞肺癌外科样品来源的SCLC6，SCLC61和SCLC108异种移植肿瘤，抑制率分别是80％，40％和78％，且对SCLC74生长长无显著抑制。^[5] 在高脂肪喂养的ApoE（-/-）小鼠中，通过管饲法给药10 mg/kg，20 mg/kg和40 mg/kg Imatinib，和对照组相比高脂诱导的脂质染色区域减少了30％，27％和35％，并且颈动脉脂质积聚得到抑制。^[6]

激酶实验：^[1]	- 合并 PDGF受体激酶活性 : PDGF受体是由BALB / c3T3细胞提取物免疫共沉淀所得，通过兔抗PDGF受体冰上处理2小时所得。蛋白A-琼脂糖珠被用于收集抗原-抗体复合物。免疫沉淀物用TNET（50 mM Tris，pH 7.5，140 mM氯化钠，5mM的EDTA，1％的Triton X-100）洗涤两次，用TNE（50 mM Tris，pH 7.5，140 mM EDTA）洗涤一次，并用激酶缓冲液（20 mM的Tris，pH 7.5, 10 mM氯化镁）洗涤一次。用PDGF（50 ng/mL）在4℃下刺激10分钟后，不同浓度的药物加入到反应混合物中。PDGF受体激酶活性是通过温浴10 μCi [³³P]-ATP和l μM ATP 10分钟来确定。免疫复合物经SDS-PAGE上的7.5％凝胶上分离。
细胞实验：^[3]	- 合并 Cell lines: BON-1 和 NCI-H727细胞 Concentrations: 约100 μM Incubation Time: 48小时 Method: BON-1细胞和NCI-H727细胞接种到平底96孔板中三个复孔，并在含10％胎牛血清的DMEM或RPMI1640完全培养基中贴壁过夜，然后更换为血清培养基（阴性对照）或含不同浓度梯度Imatinib的无血清培养基。48小时（对照培养物没有达到汇合）后，代谢活性细胞的数量是由3-（4,5-二甲基吡啶-2-基）-2,5-二苯基溴化测定，由帕卡德光谱酶标仪测定540nm处吸光度。生长抑制通过以下公式计算：抑制率=(1 − a / b) × 100%，其中a和b分别是治疗组和对照组的吸光度值。 (Only for Reference)
动物实验：^[5]	- 合并 Animal Models: SCLC6, SCLC61, SCLC 74 and SCLC108 小细胞肺癌注入瑞士小鼠 (nu/nu, 雌性）。 Dosages: 70或100 mg/kg Administration: 腹腔注射 (Only for Reference)

参考文献

- 合并

溶解度 (25°C)

体外	DMSO	118 mg/mL (200.09 mM)
	Water	118 mg/mL (200.09 mM)
	Ethanol	Insoluble

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Imatinib (STI571) Mesylate SDF

分子量	589.71
化学式	C₂₉H₃₁N₇O.CH₄SO₃
CAS号	220127-57-1
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	Gleevec, Glivec, CGP-57148B

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02687425	Unknown status	Drug: Pioglitazone\|Drug: imatinib mesylate	Leukemia Myelogenous Chronic BCR-ABL Positive	Meng Li\|Tongji Hospital	February 2016	Phase 2
NCT02303899	Completed	Drug: Gemcitabine\|Drug: Imatinib mesylate	Mesothelioma Malignant	Istituto Clinico Humanitas	November 2014	Phase 2
NCT01898377	Terminated	Drug: Imatinib mesylate Mycophenolate mofetil	Chronic Graft-versus-host Disease	Seoul National University Hospital	August 2013	Phase 2
NCT02891395	Completed	Drug: Imatinib Mesylate and Nilotinib	Graft Versus Host Disease	University Hospital Lille\|Novartis	December 24 2012	Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

选择性强的Bcr-Abl抑制剂

Nilotinib (AMN-107) : Bcr-Abl-selective, IC50<30 nM.
活性最高的Bcr-Abl抑制剂

GZD824 : Bcr-Abl(WT), IC50=0.34 nM; Bcr-Abl(T315I), IC50=0.68 nM.
FDA批准的Bcr-Abl抑制剂

Dasatinib : Approved by FDA for CML and Ph+ ALL.
最新的Bcr-Abl抑制剂

GZD824 : Orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

研究领域

产品类型

定制您的化合物库

Imatinib (STI571) Mesylate

客户使用Selleck生产的Imatinib (STI571) Mesylate发表文献180篇：

产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Imatinib (STI571) Mesylate SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-09-06)

技术支持

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

相关Bcr-Abl产品