Imatinib (STI571) Mesylate

For research use only. Not for use in humans.

目录号:S1026 别名: Gleevec, Glivec, CGP-57148B 中文名称:甲磺酸伊马替尼

Imatinib (STI571) Mesylate Chemical Structure

CAS No. 220127-57-1

Imatinib Mesylate (STI571, CGP-57148B)是一种口服生物有效的Imatinib甲磺酸盐,是一种多靶点抑制剂,作用于v-Ablc-KitPDGFR,在无细胞和细胞试验中,IC50分别为0.6 μM,0.1 μM 和0.1 μM。Imatinib Mesylate (STI571) 可诱导自噬。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1567.38 现货
RMB 780.01 现货
RMB 1603.82 现货
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客户使用Selleck生产的Imatinib (STI571) Mesylate发表文献180篇:

产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

产品描述 Imatinib Mesylate (STI571, CGP-57148B)是一种口服生物有效的Imatinib甲磺酸盐,是一种多靶点抑制剂,作用于v-Ablc-KitPDGFR,在无细胞和细胞试验中,IC50分别为0.6 μM,0.1 μM 和0.1 μM。Imatinib Mesylate (STI571) 可诱导自噬。
靶点
PDGFR [1]
(Cell-free assay)
c-Kit [2]
(M-07e cells)
v-Abl [1]
(Cell-free assay)
100 nM 100 nM 600 nM
体外研究

抑制酪氨酸和丝氨酸/苏氨酸蛋白激酶的体外测定法显示Imatinib有效抑制V-Abl酪氨酸激酶和PDGFR,IC50分别为0.6 μM和0.1 μM。[1] Imatinib抑制SLF-依赖性激活的野生型的c-kit激酶活性,IC 50约为0.1 μM,这类似抑制PDGFR所需的浓度。[2] Imatinib表现出对人支气管类癌细胞系NCI-H727和人胰腺类癌细胞系BON-1的抑制作用,IC50分别为32.4 μM和32.8 μM。 [3] 最近的一项研究显示,Imatinib通过下调hERG1 K(+)通道发挥在慢性粒细胞白血病的抗白血病作用,hERG1 K(+)通道在白血病细胞中高表达并表现有利于白血病出现。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GIST882 NVLLdJZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvmbG06PiCq MkLwTWM2OD1zLkeg{txO M370VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUCwNlEzLz5{NEmwNFIyOjxxYU6=
K562 MnPaR5l1d3SxeHnjbZR6KEG|c3H5 NVT5bWNyOjRiaB?= MXjJR|UxRTBwMkGg{txO NYrYU5JZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNFAzODdpPkKyNFAxOjB5PD;hQi=>
MCF-7 M4HnXWN6fG:2b4jpZ4l1gSCDc4PhfS=> MV2yOEBp MX\JR|UxRTBwOEOg{txO NGjCWmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkCwNFIxPyd-MkKwNFAzODd:L3G+
MDA-MB-23 NGnDT|VEgXSxdH;4bYNqfHliQYPzZZk> NHzvTHozPCCq MnLaTWM2OD1zLkig{txO MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjByMEKwO{c,OjJyMECyNFc9N2F-
K562r NUWzVFJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTFywrFOwG0> MnL6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7M{m0NVgoRjJ2OUO5OFE5RC:jPh?=
K562 MornS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\USWM2OD1yLkC5JO69VQ>? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjZ5OESxOEc,OTZ4N{i0NVQ9N2F-
MCF-7 Mn3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYD4dHU{OTBizszN MWW0PEBp NIjwWpBjdG:la4OgZ4VtdCCycn;sbYZmemG2aX;uJIlv[3KnYYPlJIlv\HWlZXSgZpkhSkp|Wh?= M376dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mke0NFM1Lz5{NUK3OFA{PDxxYU6=
K-562  Mn3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TBfGlEPTB;MTFOwG0> M3;2blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MkO5OlYzLz5{NUKzPVY3OjxxYU6=
K562  NVHTR5JkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYCzXVFqUUN3ME2wMlXDqM7:TR?= M17L[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUO5OFE5Lz5{NEmzPVQyQDxxYU6=
PC3  M{m3[mFxd3C2b4Ppd{BCe3OjeR?= NXvBdYR[OjEkgJpOwG0> NFXEcY41QC95MjDo M4TBNolv[3KnYYPld{Bk\WyuIIP1dpZqfmGu MnnmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5OE[2OVYoRjJ3N{i2OlU3RC:jPh?=
PC3  MV7D[YxtKF[rYXLpcIl1gSCDc4PhfS=> M2HOZ|Ix6oDLzszN MVm2MVczKGh? NVTWW5hKcW6lcnXhd4V{KGOnbHygeoli[mmuaYT5 NXTuOmdWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PFY3PTZpPkK1O|g3PjV4PD;hQi=>
DU145 NXj0OndQSXCxcITvd4l{KEG|c3H5 MWSyNQKBkc7:TR?= NG\i[|Y1QC95MjDo MVzpcoR2[2W|IHPlcIwh\GWjdHigZpkh[XCxcITvd4l{ Ml\HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5OE[2OVYoRjJ3N{i2OlU3RC:jPh?=
DU145 NGHNbldE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MWGyNQKBkc7:TR?= Ml:yOk04OiCq NV\vN2hl\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5 M{PBW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{i2OlU3Lz5{NUe4OlY2PjxxYU6=
Hep G2 MkS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTNzIN88US=> Ml3YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6NkOyN|IoRjJ3OE[zNlMzRC:jPh?=
T47D  NUDEbWg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWL5NlR5UUN3ME21NEDPxE1? M3K2S|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OE[zNlMzLz5{NUi2N|I{OjxxYU6=
EOL-1 M1;uOGN6fG:2b4jpZ4l1gSCjc4PhfS=> MVe3NkBpenN? NFe5U3NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBGV0xvMTDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCwMlAxODJizszNMi=> MnjxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
EOL-1 M3qwW2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 M3vhNVczKGi{cx?= MoDPRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCHT1ytNUBk\WyuczDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1utPEBie3OjeTygS2k2OCB;IECuNFAyKM7:TT6= MnjQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NESxOFkoRjJ7NUS0NVQ6RC:jPh?=
GISTT1 MkO1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M2fLRVczKGi{cx?= M3;ZeWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1nTWHQyKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG|c3H5MEBIUTVyIE2gNE4xODNizszNMi=> MmmwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
Sf9 NXjGWWd1TnWwY4Tpc44h[XO|YYm= NXj0[Fd4SmmwZHnu[{Bi\m[rbnn0fUB1dyCqdX3hckBi[3SrdnWgd4l1\SCxZjDOMZRmem2rbnHsJIhmgGGqaYP0bYRqdmVvdHHn[4VlKEGETEKg[ZhxemW|c3XkJIlvKFS{aXPoc5BtfXOrYTDubUBqdm[nY4Tl[EBU\jliY3XscJMh[nliaYPveIhmem2jbDD0bZRz[XSrb36gZ4Ftd3KrbXX0dolkKGG|c3H5MEBM\CB;IECuNFA3KM7:TT6= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTRzN{O0N{c,OjF2MUezOFM9N2F-
K562 MVHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NITKZZBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHntZZRqdmmkLYLld4l{fGGwdDDLOVYzKGOnbHzzMEBKSzVyIE2gNE4xODZyNTFOwG0v MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN5NkW4O{c,OjF|N{[1PFc9N2F-
GISTT1 MV3BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mom1O|IhcHK| M{\wXGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgZ2tKXCCmZYDlcoRmdnRiaIXtZY4hT0mVVGSxJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD6wNFgh|ryPLh?= NIWyOWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O|cxPSd-MkewO|c4ODV:L3G+
GISTT1 MmfQRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NEjsSGI4OiCqcoO= MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeLU2TUNUBk\WyuczDt[YF{fXKnZDDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1u4JIF{e2G7LDDHTVUxKD1iMD6wNFgh|ryPLh?= M3;nO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GISTT1 MYLGeY5kfGmxbjDhd5NigQ>? M1PRN|czKGi{cx?= NF;iNFJKdmirYnn0bY9vKG:oIFvJWEBqdiCqdX3hckBIUVOWVEGgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFEh|ryPLh?= MmGzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5N{OxOVMoRjJ|N{ezNVU{RC:jPh?=
BAF3 M4mweGZ2dmO2aX;uJIF{e2G7 MW[3NkBpenN? MknPTY5pcWKrdHnvckBw\iCWRVyt[pV{\WRiUFTHSnJidHCqYTCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W|ZTDCRWY{KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG|c3H5MEBIUTVyIE2gNE4xOTB5IN88UU4> M3:zXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
TF1 MUXDfZRwfG:6aXPpeJkh[XO|YYm= M1jLc2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHRHOSClZXzsd{BmgHC{ZYPzbY5oKGNvS1nUJI12fGG2aX;uJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5MEBKSzVyIE2gNE4xOTNizszNMi=> NGjy[og9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNVIxOSd-MkKyNlEzODF:L3G+
GIST882 NUn6VIY{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NW\sVmM3PzJiaILz NUDkSHlISW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBkU0mWIHTldIVv\GWwdDDoeY1idiCJSWPUPFgzKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkh[2WubITpeIVzNWeubz;DR2s5KGG|c3H5MEBIUTVyIE2gNE4xOTRizszNMi=> MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
GIST882 MlvhRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NXHnVXNpPzJiaILz NGXjVpRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfJV3Q5QDJiY3XscJMhdWWjc4Xy[YQh[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMQCCjc4PhfUwhT0l3MDC9JFAvODF2IN88UU4> M33L[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
BA/F3 M4r1[2Z2dmO2aX;uJIF{e2G7 NEfvV|E4OiCqcoO= MkHwTY5pcWKrdHnvckBw\iCNaYSg[ZhwdiBzMTDk[YxmfGmxbjCoOVU4KHSxIEW1PEBz\XOrZIXld{khdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkCxO{DPxE1w MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BA/F3 NEXjeYZHfW6ldHnvckBie3OjeR?= M1HXOFczKGi{cx?= MlHjTY5pcWKrdHnvckBw\iCWRVyt[pV{\WRiUFTHSnJj\XSjIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUy16IHHzd4F6NCCJSUWwJF0hOC5yMUmg{txONg>? MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2NEG0PUc,Ojl3NESxOFk9N2F-
BAF3 Mmf4SpVv[3Srb36gZZN{[Xl? NGf5NHE4OiCqcoO= MWDJcohq[mm2aX;uJI9nKFSnbD3meZNm\CCSRFfGVk1j\XSjIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJGJCTjNiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25ibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONODDhd5NigSxiR1m1NEA:KDBwMEG5JO69VS5? NXj5Z5VCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
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MEG01 NGX0eXJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MVu3NkBpenN? NEDtfXJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3FS|AyKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT|gh[XO|YYmsJGdKPTBiPTCwMlA4PCEQvF2u NVPq[|M5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
Ba/F3 MVvGeY5kfGmxbjDhd5NigQ>? M3fsWFQ5KGi{cx?= MlvnTY5pcWKrdHnvckBw\iCEQ2KtRWJNOSCJMkWwTEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hdW:3c3WgRoEwTjNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBDS1JvQVLMNU1u\WSrYYTl[EBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOFghcHK|IHL5JGJzcXSnTHnnbJQhdHWlaX\ldoF{\SCjc4PhfUwhT0l3MDC9JFAvODd5MTFOwG0v NUPu[VdbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxN|c6QDFpPkOwNVM4QThzPD;hQi=>
BA/F3 MVnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NGfBPJI2KHSxIEGwJJVO NXXrXWFVPDhiaILz MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy|IHX4dJJme3OrbnegWIVtNVOKMz3TTFIuU0RiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYYSgOUB1dyBzMDD1UUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4xQDhizszNMi=> Mn[5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2MUW4OlMoRjF4NEG1PFY{RC:jPh?=
BA/F3 NH\OPWpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NV;G[GJjPDhiaILz NI\tPYtIem:5dHigbY5pcWKrdHnvckBw\iCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIIfpcIQufHmyZTDCZ5IuSWKuIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkC4PUDPxE1w MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV4MkKxO{c,OjZ3NkKyNVc9N2F-
K562 NH3TTG5HfW6ldHnvckBie3OjeR?= Mm[zN|AhdWmwcx?= M3vKS2lvcGmkaYTpc44hd2Zia3nuc4Jm[WRiYnnu[Ilv\yC2bzDESHIyKGmwIHj1cYFvKEt3NkKgZ4VtdHNiaX7jeYJifGWmIH\vdkA{OCCvaX7zJIJ6KGmWUlHRJJJm[WenboStZoF{\WRibXHzd{B{eGWldILvcYV1emmlIH3leIhw\CxiSVO1NEA:KDBwMEmg{txONg>? MmLhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OECyOlEoRjJ6MkiwNlYyRC:jPh?=
Ba/F3 M2Xv[2Z2dmO2aX;uJIF{e2G7 NXLNWXdyPDhiaILz MYnJcohq[mm2aX;uJI9nKHerbHSgeJlx\SCEQ2KtRWJNOSBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEYT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB2ODDodpMh[nliQoLpeIVNcWeqdDDseYNq\mW{YYPlJIF{e2G7LDDHTVUxKD1iMD6wPVA2KM7:TT6= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF|N{m4NUc,OzBzM{e5PFE9N2F-
BA/F3 M3PwNmN6fG:2b4jpZ4l1gSCjc4PhfS=> MnzYOFghcHK| M3;ZfGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z|IHPlcIx{KHS{YX7z[oVkfGWmIIfpeIghf2muZDD0fZBmKEKlcj3BZowh[W[2ZYKgOFghcHK|IHL5JHhVXCCjc4PhfUwhUUN3MDC9JFAvODl{IN88UU4> NIfQV3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNFgxPid-MkO2NFA5ODZ:L3G+
GIST882 NHXueW5HfW6ldHnvckBie3OjeR?= M3fLe2lvcGmkaYTpc44hd2ZiaIXtZY4hU0mWIHH1eI9xcG:|cHjvdplt[XSrb36gbY4hcHWvYX6gS2lUXDh6MjDj[YxteyCkeTDFUGlUSSxiSVO1NEA:KDBwMEm3JO69VS5? Mm\iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N|goRjJyOEG3OVM5RC:jPh?=
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insect M2\RV2Z2dmO2aX;uJIF{e2G7 NWXvS5d4OzBibXnudy=> MljQTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCC5aXzkJJR6eGViQVLMNUBmgHC{ZYPz[YQhcW5iaX7z[YN1KGOnbHzzJIFnfGW{IEOwJI1qdnNiYomgSnJGXCCjc4PhfUwhUUN3MDC9JFAvODl6MjFOwG0v NWe4S3IyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN|AyPzB|PD;hQi=>
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primary leukemia cells NHTVe4dEgXSxdH;4bYNqfHliYYPzZZk> M3e3V|czKGi{cx?= NFHpOppEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBxemmvYYL5JIxmfWunbXnhJINmdGy|IHnzc4xifGWmIH\yc40h[WO3dHWgcZlmdG:rZDDs[ZVs\W2rYTDwZZRq\W62IHX4dJJme3Orbnege4lt\CC2eYDlJGZNXDNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGy3Y3nm[ZJie2ViYYPzZZktKEmFNUCgQUAxNjFizszNMi=> MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ{MUKwNUc,OjJ{MkGyNFE9N2F-
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K562 Mnn5R5l1d3SxeHnjbZR6KGG|c3H5 M2Kyc|I1KGi{cx?= M3v3T2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOSEQvF2u NXrQcnd6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2N|I6OzVpPkKyOlMzQTN3PD;hQi=>
BA/F3 M{jPZ2Z2dmO2aX;uJIF{e2G7 MnXSO|IhcHK| Mom1TY5pcWKrdHnvckBw\iCWRVyt[pV{\WRiUFTHSnJj\XSjIDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmEwTjNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFNiYYPzZZktKEeLNUCgQUAxNjFyMjFOwG0v NWrkPJVnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BAF3 MlrJSpVv[3Srb36gZZN{[Xl? MkGzO|IhcHK| MVfJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClLVvJWEBNPTd4UDDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0t6IHHzd4F6NCCJSUWwJF0hOC5zMEKg{txONg>? NXjmW2QzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GIST882 NHTxWWJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NY\ITYxlSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHTXNVQDh{IHPlcIx{NCCLQ{WwJF0hOC5zMEig{txONg>? MnvaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N|goRjJyOEG3OVM5RC:jPh?=
GIST882 Mny1SpVv[3Srb36gZZN{[Xl? NEXp[JJKdmirYnn0bY9vKG:oIFvJWEBMPjR{RTDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gbJVu[W5iR1nTWFg5OiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KEGWUD3k[ZBt\XSrb36gZZN{[XluIFnDOVAhRSByLkGwPEDPxE1w M2K3NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkGxO|cyLz5{M{[xNVc4OTxxYU6=
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KU812 NXO4b5RKSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MVG3NkBpenN? NF7mVlFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFvVPFEzKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG|c3H5MEBIUTVyIE2gNE4yOSEQvF2u Ml7JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
BA/F3 NEDjVYFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NHW1NJU4OiCqcoO= MonuRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCEQT;GN{Bk\WyuczDlfJBz\XO|aX7nJGJkei2DYnygTFM6PlBibYX0ZY51KGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDBwMUGg{txONg>? NHGweJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C4PFY1PCd-MkOwPFg3PDR:L3G+
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insect cells M3\YeGZ2dmO2aX;uJIF{e2G7 M3f0bFMxKG2rboO= MV\Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEGETEGgUVM2OVRibYX0ZY51KGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMh[W[2ZYKgN|AhdWmwczDifUBHWkWWIHHzd4F6NCCLQ{WwJF0hOC5zMUSzJO69VS5? NE\QSWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
insect cells MnfaSpVv[3Srb36gZZN{[Xl? MYSzNEBucW6| M1:ydWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiQVLMNUBSOjV{SDDteZRidnRiZYjwdoV{e2WmIHnuJIlve2WldDDj[YxteyCjZoTldkA{OCCvaX7zJIJ6KE[URWSgZZN{[XluIFnDOVAhRSByLkGxOUDPxE1w NISxbnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
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Calu-6 M2D6bGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 Mm\RTY5pcWKrdHnvckBw\iCqdX3hckBE[Wy3LU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFM{NjF6NUWg{txONg>? NVvtNZZFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
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YT NESwV3ZIem:5dHigTY5pcWKrdHnvckBie3OjeR?= M4PJe2lvcGmkaYTpc44hd2ZiaIXtZY4hYVRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEO4MlUzODlizszNMi=> Mk\BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
TE-6 M2HpXGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 MVrJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IESxMlI4QTdizszNMi=> MmXpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
HT-144 NXnJdIh[T3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= MnH6TY5pcWKrdHnvckBw\iCqdX3hckBJXC1zNESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQyNjV2OE[g{txONg>? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
EW-13 MVzHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? NHPocnNKdmirYnn0bY9vKG:oIHj1cYFvKEWZLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1Oi5{N{mxJO69VS5? Mm\vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
KALS-1 M4fGVGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 NVfxTY9ZUW6qaXLpeIlwdiCxZjDoeY1idiCNQVzTMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDR|LkGzNlgh|ryPLh?= NFT1R2U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
MOLT-16 NF\LO4VIem:5dHigTY5pcWKrdHnvckBie3OjeR?= MW\Jcohq[mm2aX;uJI9nKGi3bXHuJG1QVFRvMU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ2NjB5NUKg{txONg>? MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
D-336MG MYfHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? M1iyOmlvcGmkaYTpc44hd2ZiaIXtZY4hTC1|M{\NS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDVwOUW5PUDPxE1w M3;Nc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
TE-11 NY[3eVZsT3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= Mn76TY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gOFYvPjV|IN88UU4> MknQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
EB2 MV\Hdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? NWrDdnFHUW6qaXLpeIlwdiCxZjDoeY1idiCHQkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ3NjZ7OTFOwG0v NVy3OXBLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
SK-N-DZ MW\Hdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? NXPYSHhZUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3OMWRbKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB2OD6wPVYyKM7:TT6= Mlj3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
SW684 M2jBWWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 NXrNeldLUW6qaXLpeIlwdiCxZjDoeY1idiCVV{[4OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDhwMk[5OUDPxE1w M3HPOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
EW-18 MlfkS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? MljITY5pcWKrdHnvckBw\iCqdX3hckBGXy1zODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gOFgvPDN7NTFOwG0v MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-STAT3 / STAT3 / p-STAT5 / STAT5; 

PubMed: 18981115     


For phospho-STAT3 and Phospho-STAT5 detection, cells were then activated for 6 hrs with anti-CD3 and anti-CD28 Ab. Equivalent amounts of protein from cell lysates were separated by SDS-PAGE and western blot analysis was then performed using anti-phospho S䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖

p-ZAP70 / ZAP70 / p-LAT / LAT; 

PubMed: 18981115     


For the analysis of imatinib interference with early TCR signaling events, cells were activated for 5 min with anti-CD3 and anti-CD28 Abs and blots were probed with anti-phospho ZAP70, anti-ZAP70, anti-phospho LAT or anti-LAT antibodies. Untreated, non-ac䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 

18981115
Immunofluorescence
RelB; 

PubMed: 20371728     


Nuclear proteins were extracted from the untreated and treated cells and nuclear levels of RelA and RelB were confirmed by immunocytochemistry 

Cortactin / F-actin; 

PubMed: 20937825     


NIH3T3-SrcY527F cells were treated with DMSO or with 10 μm STI571 for 16 h, fixed and co-stained for cortactin (red, left panels) and F-actin (green, middle panels). Merged fields (right panels) demonstrate co-localization between cortactin and F-actin at䲧疝Ỵ疞㧀疜

20371728 20937825
Growth inhibition assay
Cell viability ; 

PubMed: 28435223     


(C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. 䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺

28435223
体内研究 Imatinib抑制从新鲜的人小细胞肺癌外科样品来源的SCLC6,SCLC61和SCLC108异种移植肿瘤,抑制率分别是80%,40%和78%,且对SCLC74生长长无显著抑制。[5] 在高脂肪喂养的ApoE(-/-)小鼠中,通过管饲法给药10 mg/kg,20 mg/kg和40 mg/kg Imatinib,和对照组相比高脂诱导的脂质染色区域减少了30%,27%和35%,并且颈动脉脂质积聚得到抑制。[6]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
- 合并

PDGF受体激酶活性 :

PDGF受体是由BALB / c3T3细胞提取物免疫共沉淀所得,通过兔抗PDGF受体冰上处理2小时所得。蛋白A-琼脂糖珠被用于收集抗原-抗体复合物。免疫沉淀物用TNET(50 mM Tris,pH 7.5,140 mM氯化钠,5mM的EDTA,1%的Triton X-100)洗涤两次,用TNE(50 mM Tris,pH 7.5,140 mM EDTA)洗涤一次,并用激酶缓冲液(20 mM的Tris,pH 7.5, 10 mM氯化镁)洗涤一次。用PDGF(50 ng/mL)在4℃下刺激10分钟后,不同浓度的药物加入到反应混合物中。PDGF受体激酶活性是通过温浴10 μCi [33P]-ATP和l μM ATP 10分钟来确定。免疫复合物经SDS-PAGE上的7.5%凝胶上分离。
细胞实验:[3]
- 合并
  • Cell lines: BON-1 和 NCI-H727细胞
  • Concentrations: 约100 μM
  • Incubation Time: 48小时
  • Method: BON-1细胞和NCI-H727细胞接种到平底96孔板中三个复孔,并在含10%胎牛血清的DMEM或RPMI1640完全培养基中贴壁过夜,然后更换为血清培养基(阴性对照)或含不同浓度梯度Imatinib的无血清培养基。48小时(对照培养物没有达到汇合)后,代谢活性细胞的数量是由3-(4,5-二甲基吡啶-2-基)-2,5-二苯基溴化测定,由帕卡德光谱酶标仪测定540nm处吸光度。生长抑制通过以下公式计算:抑制率=(1 − a / b) × 100%,其中a和b分别是治疗组和对照组的吸光度值。
    (Only for Reference)
动物实验:[5]
- 合并
  • Animal Models: SCLC6, SCLC61, SCLC 74 and SCLC108 小细胞肺癌注入瑞士小鼠 (nu/nu, 雌性)。
  • Dosages: 70或100 mg/kg
  • Administration: 腹腔注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 118 mg/mL (200.09 mM)
Water 118 mg/mL (200.09 mM)
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 589.71
化学式

C29H31N7O.CH4SO3

CAS号 220127-57-1
储存条件 粉状
溶于溶剂
别名 Gleevec, Glivec, CGP-57148B

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02687425 Unknown status Drug: Pioglitazone|Drug: imatinib mesylate Leukemia Myelogenous Chronic BCR-ABL Positive Meng Li|Tongji Hospital February 2016 Phase 2
NCT02303899 Completed Drug: Gemcitabine|Drug: Imatinib mesylate Mesothelioma Malignant Istituto Clinico Humanitas November 2014 Phase 2
NCT01898377 Terminated Drug: Imatinib mesylate Mycophenolate mofetil Chronic Graft-versus-host Disease Seoul National University Hospital August 2013 Phase 2
NCT02891395 Completed Drug: Imatinib Mesylate and Nilotinib Graft Versus Host Disease University Hospital Lille|Novartis December 24 2012 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID