Imatinib (STI571) Mesylate

For research use only. Not for use in humans.

目录号:S1026 别名: Gleevec, Glivec, CGP-57148B 中文名称:甲磺酸伊马替尼

Imatinib (STI571) Mesylate Chemical Structure

CAS No. 220127-57-1

Imatinib Mesylate (STI571, CGP-57148B)是一种口服生物有效的Imatinib甲磺酸盐,是一种多靶点抑制剂,作用于v-Ablc-KitPDGFR,在无细胞和细胞试验中,IC50分别为0.6 μM,0.1 μM 和0.1 μM。Imatinib Mesylate (STI571) 可诱导自噬。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1567.38 现货
RMB 780.01 现货
RMB 1603.82 现货
有超大折扣

今日订购,明日送达,全国免运费!

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Imatinib (STI571) Mesylate发表文献198篇:

产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

产品描述 Imatinib Mesylate (STI571, CGP-57148B)是一种口服生物有效的Imatinib甲磺酸盐,是一种多靶点抑制剂,作用于v-Ablc-KitPDGFR,在无细胞和细胞试验中,IC50分别为0.6 μM,0.1 μM 和0.1 μM。Imatinib Mesylate (STI571) 可诱导自噬。
靶点
PDGFR [1]
(Cell-free assay)
c-Kit [2]
(M-07e cells)
v-Abl [1]
(Cell-free assay)
100 nM 100 nM 600 nM
体外研究

抑制酪氨酸和丝氨酸/苏氨酸蛋白激酶的体外测定法显示Imatinib有效抑制V-Abl酪氨酸激酶和PDGFR,IC50分别为0.6 μM和0.1 μM。[1] Imatinib抑制SLF-依赖性激活的野生型的c-kit激酶活性,IC 50约为0.1 μM,这类似抑制PDGFR所需的浓度。[2] Imatinib表现出对人支气管类癌细胞系NCI-H727和人胰腺类癌细胞系BON-1的抑制作用,IC50分别为32.4 μM和32.8 μM。 [3] 最近的一项研究显示,Imatinib通过下调hERG1 K(+)通道发挥在慢性粒细胞白血病的抗白血病作用,hERG1 K(+)通道在白血病细胞中高表达并表现有利于白血病出现。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GIST882 NWf2VFZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLtPVYhcA>? NYrXVYUyUUN3ME2xMlch|ryP NWDWe5RuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFAzOTJpPkK0PVAxOjF{PD;hQi=>
K562 NYjvNplZS3m2b4TvfIlkcXS7IFHzd4F6 NWLpN3JbOjRiaB?= NInqN5RKSzVyPUCuNlEh|ryP MkTtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMECyNFcoRjJ{MECwNlA4RC:jPh?=
MCF-7 Mkf4R5l1d3SxeHnjbZR6KEG|c3H5 NWq0VmpiOjRiaB?= Mkn6TWM2OD1yLkizJO69VQ>? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjByMEKwO{c,OjJyMECyNFc9N2F-
MDA-MB-23 NG\kSmFEgXSxdH;4bYNqfHliQYPzZZk> M4W2clI1KGh? M3q0PGlEPTB;MT64JO69VQ>? NIPGVII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkCwNFIxPyd-MkKwNFAzODd:L3G+
K562r NUPxPIRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;rflBKSzVyPUGwxsDPxE1? M{XuUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUO5OFE5Lz5{NEmzPVQyQDxxYU6=
K562 NVLpdGVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M320emVEPTB;MD6wPUDPxE1? NXrxTGJVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[2O|g1OTRpPkG2Olc5PDF2PD;hQi=>
MCF-7 NYn2e2VET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnDV3IyOCEQvF2= M2XNd|Q5KGh? NIXKbFFjdG:la4OgZ4VtdCCycn;sbYZmemG2aX;uJIlv[3KnYYPlJIlv\HWlZXSgZpkhSkp|Wh?= Mk\LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{N{SwN|QoRjJ3Mke0NFM1RC:jPh?=
K-562  NWm0SldYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\3TWM2OD1zIN88US=> MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ|OU[2Nkc,OjV{M{m2OlI9N2F-
K562  MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrzWXREUUN3ME2wMlXDqM7:TR?= NFq5WnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmzPVQyQCd-MkS5N|k1OTh:L3G+
PC3  M{jFVWFxd3C2b4Ppd{BCe3OjeR?= NF7NXWozOOLCid88US=> MnLNOFgwPzJiaB?= MljKbY5kemWjc3XzJINmdGxic4Xyeol3[Wx? MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd6Nk[1Okc,OjV5OE[2OVY9N2F-
PC3  NVTQU29tS2WubDDWbYFjcWyrdImgRZN{[Xl? M1L5WFIx6oDLzszN M{TqcFYuPzJiaB?= MofmbY5kemWjc3XzJINmdGxidnnhZoltcXS7 NULkWJdxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PFY3PTZpPkK1O|g3PjV4PD;hQi=>
DU145 MnPORZBweHSxc3nzJGF{e2G7 Mn72NlDjiIoQvF2= MVm0PE84OiCq M4Pa[olv\HWlZYOgZ4VtdCCmZXH0bEBjgSCjcH;weI9{cXN? NXnxUJdPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PFY3PTZpPkK1O|g3PjV4PD;hQi=>
DU145 MXnD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MUiyNQKBkc7:TR?= MWO2MVczKGh? M2Xz[4Rm[3KnYYPld{Bk\WyuII\pZYJqdGm2eR?= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd6Nk[1Okc,OjV5OE[2OVY9N2F-
Hep G2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;sRnU{UUN3ME2zNUDPxE1? NFOzWZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi2N|I{Oid-MkW4OlMzOzJ:L3G+
T47D  MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfxTWM2OD13MDFOwG0> Mn20QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6NkOyN|IoRjJ3OE[zNlMzRC:jPh?=
EOL-1 NF[2UmVEgXSxdH;4bYNqfHliYYPzZZk> MV[3NkBpenN? NHi3XlVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBGV0xvMTDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCwMlAxODJizszNMi=> NWjxeHBoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
EOL-1 M4jOV2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mk\aO|IhcHK| MW\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEWRTD2xJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFSz24JIF{e2G7LDDHTVUxKD1iMD6wNFEh|ryPLh?= MnHyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NESxOFkoRjJ7NUS0NVQ6RC:jPh?=
GISTT1 NXPDWFBNSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NUP3eoZ[PzJiaILz NV;wWWVVSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHTXNVXDFiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdCC2aYTldk1odG9iYYPzZZktKEeLNUCgQUAxNjByMzFOwG0v MmDMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
Sf9 MlnISpVv[3Srb36gZZN{[Xl? MnPXRolv\GmwZzDh[oZqdmm2eTD0c{BpfW2jbjDhZ5RqfmVic3n0[UBw\iCQLYTldo1qdmGuIHjlfIFpcXO2aXTpcoUufGGpZ3XkJGFDVDJiZYjwdoV{e2WmIHnuJHRzcWOqb4DseZNq[SCwaTDpcoZm[3SnZDDT[lkh[2WubIOgZpkhcXOxdHjldo1idCC2aYTyZZRqd25iY3Hsc5JqdWW2cnnjJIF{e2G7LDDL[EA:KDBwMEC2JO69VS5? NHm5XoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUSxO|M1Oyd-MkG0NVc{PDN:L3G+
K562 NEnlV2JCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Mnz5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCrbXH0bY5q[i2{ZYPpd5RidnRiS{W2NkBk\WyuczygTWM2OCB;IECuNFA3ODVizszNMi=> MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN5NkW4O{c,OjF|N{[1PFc9N2F-
GISTT1 NIT3T2dCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MWO3NkBpenN? NHz0ZllCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JINMUVRiZHXw[Y5l\W62IHj1cYFvKEeLU2TUNUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JINmdGy2aYTldk1odG9xQ1PLPEBie3OjeTygS2k2OCB;IECuNFA5KM7:TT6= M4LBTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O|A2Lz5{N{C3O|cxPTxxYU6=
GISTT1 MYrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NUTUV|kyPzJiaILz MkPrRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCJSWPUWFEh[2WubIOgcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLPEBie3OjeTygS2k2OCB;IECuNFA5KM7:TT6= Mn\hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
GISTT1 M2CxRmZ2dmO2aX;uJIF{e2G7 NXnESWdpPzJiaILz Ml7oTY5pcWKrdHnvckBw\iCNSWSgbY4hcHWvYX6gS2lUXFRzIHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCVUlKgZZN{[XluIFfJOVAhRSByLkCxJO69VS5? NV25dJUyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3O|MyPTNpPkKzO|c{OTV|PD;hQi=>
BAF3 M3j4XGZ2dmO2aX;uJIF{e2G7 NHG5dIw4OiCqcoO= NUnWfGN{UW6qaXLpeIlwdiCxZjDUSWwu\nW|ZXSgVGRITlKjbIDoZUApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCvb4Xz[UBDSUZ|IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JINmdGxidHn0[ZIu\2yxIHHzd4F6NCCJSUWwJF0hOC5yMUC3JO69VS5? MnLEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
TF1 MlXlR5l1d3SxeHnjbZR6KGG|c3H5 Mnq3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWGYyKGOnbHzzJIV5eHKnc4Ppcoch[y2NSWSgcZV1[XSrb36gZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImsJGlEPTBiPTCwMlAyOyEQvF2u NFm0b2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNVIxOSd-MkKyNlEzODF:L3G+
GIST882 NIDseIpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NEDGUFM4OiCqcoO= M1HyZWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgZ2tKXCCmZYDlcoRmdnRiaIXtZY4hT0mVVEi4NkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JINmdGy2aYTldk1odG9xQ1PLPEBie3OjeTygS2k2OCB;IECuNFE1KM7:TT6= MlXLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O|A2RC:jPh?=
GIST882 MkLiRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NHvPWFY4OiCqcoO= M3S3NmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1nTWFg5OiClZXzsd{Bu\WG|dYLl[EBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2s5KGG|c3H5MEBIUTVyIE2gNE4xOTRizszNMi=> MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
BA/F3 MnTZSpVv[3Srb36gZZN{[Xl? NIPudlk4OiCqcoO= NXT4R2Z[UW6qaXLpeIlwdiCxZjDLbZQh\XixbjCxNUBl\WyndHnvckApPTV5IITvJFU2QCC{ZYPp[JVmeylibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGdKPTBiPTCwMlAyPyEQvF2u M{PlZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5|MEKwOFQ1OTxxYU6=
BA/F3 NH;DZWlHfW6ldHnvckBie3OjeR?= NGnFWWo4OiCqcoO= M{flNGlvcGmkaYTpc44hd2ZiVFXMMYZ2e2WmIGDES2ZT[mW2YTCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W|ZTDCRU9HOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0tvODDhd5NigSxiR1m1NEA:KDBwMEG5JO69VS5? MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2NEG0PUc,Ojl3NESxOFk9N2F-
BAF3 M3PQUGZ2dmO2aX;uJIF{e2G7 NIHNNlk4OiCqcoO= MkfoTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiUFTHSnIu[mW2YTCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBDSUZ|IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFS{igZZN{[XluIFfJOVAhRSByLkCxPUDPxE1w MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GIST882 NHrWdmxCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M4PsT|czKGi{cx?= MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeLU2S4PFIh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3ncI8h[XO|YYmsJGdKPTBiPTCwMlAzKM7:TT6= Mmj3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
BAF3 NYHZcnJETnWwY4Tpc44h[XO|YYm= MnrmO|IhcHK| NIXnNXlKdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDjT2lVKEN4N{TTJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W|ZTDCRWY{KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG|c3H5MEBIUTVyIE2gNE4xOjR7IN88UU4> NYLLZ41zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1OFE3QTVpPkK4OVQyPjl3PD;hQi=>
BA/F3 MXvBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NFTrOFk1QCCqcoO= NE\xeGpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KEKlcj3hZowhdmWpYYTpeoUh[2WubIOg[ZhxemW|c3nu[{BV\WxvUFTHSnJj\XSjIHvpcoF{\SCjc4Pld5Nm\CCjczDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjB{NzFOwG0v NI\RZlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkSxOVg3Oyd-MU[0NVU5PjN:L3G+
HL60 NI\3S2dCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NYW0dYxEPzJiaILz NFSySWFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjMOlAh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKHO3co\peoFtKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjB|IN88UU4> NX\kemxqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[4OVAxODRpPkK2PFUxODB2PD;hQi=>
BAF3 NFK0OFZHfW6ldHnvckBie3OjeR?= NGGwXIs4OiCqcoO= Mn[zTY5pcWKrdHnvckBw\iCqdX3hckB4cWymIIT5dIUhSkOULVHCUEBmgHC{ZYPz[YQhcW5ibX;1d4UhSkGIMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCHQ{WwJF0hOC5yM{Sg{txONg>? M2TzdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEGwPFExLz5{N{CxNFgyODxxYU6=
BA/F3 NFPVTnVHfW6ldHnvckBie3OjeR?= MUW3NkBpenN? NG\oZYdKdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDQSGdHWmGucHjhJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKG2xdYPlJGJCN0Z|IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFSz24JIF{e2G7LDDHTVUxKD1iMD6wN|Qh|ryPLh?= M2\TfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUS0NVQ6Lz5{OUW0OFE1QTxxYU6=
BAF3 MnjkSpVv[3Srb36gZZN{[Xl? MXi3NkBpenN? NYHI[FdTUW6qaXLpeIlwdiCxZjDU[Ywu\nW|ZXSgVGRITlJvYXzwbIEhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBu\WG|dYLl[EBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2s5KGG|c3H5MEBIUTVyIE2gNE4xOzRizszNMi=> NXLGOZBWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
BAF3 MnW1SpVv[3Srb36gZZN{[Xl? NYLKXYdwPzJiaILz MorvTY5pcWKrdHnvckBw\iCWRVyt[pV{\WRiY1vJWEBXPTV7RDDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzsJJRqfGW{LXfsc{Bie3OjeTygS2k2OCB;IECuNFM3KM7:TT6= M2Xa[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
BA/F3 MUjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mn;6RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDQSGdHWmKndHGgeJJidnOoZXP0[YQhdW:3c3WgRmEwTjNiY3XscJMtKEmFNUCgQUAxNjB|OTFOwG0v Mkf2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N|goRjJyOEG3OVM5RC:jPh?=
BAF3 NVyxVnd7TnWwY4Tpc44h[XO|YYm= MmfOO|IhcHK| MWjJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClS1nUJHY2PTmGIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvM2NEUzhiYYPzZZktKEeLNUCgQUAxNjB|OTFOwG0v M4LYPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O|A2Lz5{N{C3O|cxPTxxYU6=
BAF3 NHz3WolHfW6ldHnvckBie3OjeR?= NX\UVpBMPzJiaILz M1zNXWlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHOtT2lVKFZ3NUnEJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBDSUZ|IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFS{igZZN{[XluIFfJOVAhRSByLkCzPUDPxE1w MlfaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
MDCK2 MVvGeY5kfGmxbjDhd5NigQ>? NV:w[XVjPSCvaX7z MonYTY5pcWKrdHnvckBw\iCqdX3hckBOSVSHMT3t[YRq[XSnZDDbNVReNW2ndH\vdo1qdiC3cIThb4Uh\XiycnXzd4VlKGmwIIDvcIFzcXqnZDDNSGNMOiClZXzsd{Bi\nSncjC1JI1qdnNiYomgcIlyfWmmIIPjbY51cWyuYYTpc44h[2:3boTpcoch[W6jbInzbZMtKEmFNUCgQUAxNjB2IN88UU4> NIfnfnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K0NVAzQSd-MkOyOFExOjl:L3G+
GISTT1 NXXUWVJ5S3m2b4TvfIlkcXS7IHHzd4F6 M2TlV|czKGi{cx?= NHrFeZVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBIUVOWVEGgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzT2yxIHHzd4F6NCCJSUWwJF0hOC5yNDFOwG0v MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl7MUS2OUc,Ojh7OUG0OlU9N2F-
HEK293 NHHrO29HfW6ldHnvckBie3OjeR?= NYjoZlJwUW6qaXLpeIlwdiCxZjDheZRweGixc4Doc5J6dGG2aX;uJI9nKESGUkGg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDifUBGVEmVQTygTWM2OCB;IECuNFQ{KM7:TT6= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzN{WzPEc,OjB6MUe1N|g9N2F-
K562 M{jmOmZ2dmO2aX;uJIF{e2G7 NHTYUlI{OCCvaX7z NH;LV3VKdmirYnn0bY9vKG:oIHvpco9j\WGmIHLpcoRqdmdidH:gUnFQOiCrbjDoeY1idiCNNU[yJINmdGy|IHnuZ5Vj[XSnZDDmc5IhOzBibXnud{BjgSCrVGLBVUBz\WGpZX70MYJie2WmIH3hd5Mhe3CnY4Tyc41mfHKrYzDt[ZRpd2RuIFnDOVAhRSByLkC0N{DPxE1w Ml\pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OECyOlEoRjJ6MkiwNlYyRC:jPh?=
MEG01 MlXuRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NHXWU4c4OiCqcoO= NVLVSJNwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSWcxOSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtKHSrdHXyMYdtdyCjc4PhfUwhT0l3MDC9JFAvODR3IN88UU4> NFjMTmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
BAF3 M1ruVWZ2dmO2aX;uJIF{e2G7 NXe1XXljPzJiaILz M{[zVGlvcGmkaYTpc44hd2ZiVFXMMYZ2e2WmIHPLTXQhVDV5NmCgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3ncI8h[XO|YYmsJGdKPTBiPTCwMlA1PTFizszNMi=> NUjKOZM4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1OFE3QTVpPkK4OVQyPjl3PD;hQi=>
MO7e NGjMbWFHfW6ldHnvckBie3OjeR?= MVjJcohq[mm2aX;uJI9nKFOFRj3pcoR2[2WmIIDoc5NxcG:{eXzheIlwdiCxZjDjMWtqfCCrbjDNU|dmKGOnbHzzJIJ6KFSULV\SSXQh[XO|YYmsJGlEPTBiPTCwMlA1PiEQvF2u M{LUflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NES3N|c6Lz5zOES0O|M4QTxxYU6=
BA/F3 M4DoUWZ2dmO2aX;uJIF{e2G7 NUGwOlcxPzJiaILz NGryeZFKdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDQSGdHWmGucHjhJEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkC0OkDPxE1w NVSwWJFiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
K562 MmnHR5l1d3SxeHnjbZR6KGG|c3H5 MVm3NkBpenN? NIf3V4REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IECuNFQ6KM7:TT6= NUDrO2ZwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
HEK293 MWTGeY5kfGmxbjDhd5NigQ>? NEPQVXMyNjVibXnudy=> NXW1ZoRsUW6qaXLpeIlwdiCxZjDoeY1idiCPQWTFNU1u\WSrYYTl[EBcOTSfLX3leIZwem2rbjD1dJRic2ViZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjZoTldkAyNjVibXnud{BjgSC|Y3nueIltdGG2aX;uJINwfW62aX7nJIFv[Wy7c3nzMEBKSzVyIE2gNE4xPSEQvF2u NIHnUHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K0NVAzQSd-MkOyOFExOjl:L3G+
BA/F3 NWHIPYZSSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MkPYOUB1dyBzMDD1US=> MX[0PEBpenN? M1P1S2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW|c3nu[{BV\WxvU1iyMWtFKGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGG2IEWgeI8hOTBidV2gZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNFU2KM7:TT6= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjRzNUi2N{c,OTZ2MUW4OlM9N2F-
HT-29 NFX0TVhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M2f6TFk3KGi{cx?= MYHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiWLUK5JINmdGy|IHHmeIVzKDl4IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSByLkC2JO69VS5? NXTpV|NrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0Olk2PDdpPkG5OFY6PTR5PD;hQi=>
K562 MWHDfZRwfG:6aXPpeJkh[XO|YYm= NXvCc5ZnS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImsJGlEPTBiPTCwMlA3KM7:TT6= M3rGcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4Mk[0OVA{Lz5{NkK2OFUxOzxxYU6=
HT-29 M3\jTmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NWfFc2ZCQTZiaILz MV3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiWLUK5JINmdGy|IHHmeIVzKDl4IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSByLkC2JO69VS5? NX7wZmJFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm3NlQ3PTNpPkK5O|I1PjV|PD;hQi=>
JURL-MK1 MULBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MkLVOFghcHK| M17sPWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSmXSUE1OUzFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JGNmdGxvVHn0[ZIuT2yxIHz1cYlv\XOlZX70JINmdGxidnnhZoltcXS7IHHzd4F6NCCJSUWwJF0hOC5yNjFOwG0v M1fqWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEGxNVU6Lz5{N{CxNVE2QTxxYU6=
BA/F3 NYnHRo9OTnWwY4Tpc44h[XO|YYm= M2TzPFczKGi{cx?= NXHPR4V6UW6qaXLpeIlwdiCxZjDLbZQhXjV4MFSgcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmEwTjNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFNiYYPzZZktKEeLNUCgQUAxNjB5IN88UU4> MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
A31 NXXYPXhsTnWwY4Tpc44h[XO|YYm= NGTYXYtKdmirYnn0bY9vKG:oIGDES2ZT[mW2YTDheZRweGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJGE{OSClZXzsd{BjgSCHTFnTRUwhUUN3MDC9JFAvODd{IN88UU4> MoD6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N|goRjJyOEG3OVM5RC:jPh?=
A31 MkTnSpVv[3Srb36gZZN{[Xl? MnviTY5pcWKrdHnvckBw\iCqdX3hckBRTEeIUnHsdIhiKGG3dH;wbI9{eGixconsZZRqd25iaX6gbJVu[W5iQUOxJINmdGy|IHL5JGVNUVODLDDJR|UxKD1iMD6wO|Ih|ryPLh?= NWHUT|R[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
MEG01 Mk\nRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M1\nclczKGi{cx?= MnvoRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCEQ2KtRWJNKGSncHXu[IVvfCCPRVewNUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JINmdGy2aYTldk1odG9xQ1PLPEBie3OjeTygS2k2OCB;IECuNFc1KM7:TT6= M2i4UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O|A2Lz5{N{C3O|cxPTxxYU6=
MEG01 NHTiWW5CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NGPS[Zo4OiCqcoO= MUjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2HR{CxJINmdGy|IH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFS{igZZN{[XluIFfJOVAhRSByLkC3OEDPxE1w MlzPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
Ba/F3 MWTGeY5kfGmxbjDhd5NigQ>? Mm\vOFghcHK| NWXtWnpFUW6qaXLpeIlwdiCxZjDCR3IuSUKOMTDHNlUxUCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSmFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCEQ2KtRWJNOS2vZXTpZZRm\CClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPDhiaILzJIJ6KEK{aYTlUIlocHRibIXjbYZmemG|ZTDhd5NigSxiR1m1NEA:KDBwMEe3NUDPxE1w MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF|N{m4NUc,OzBzM{e5PFE9N2F-
BA/F3 MoHpRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Mn;YOUB1dyBzMDD1US=> MnjOOFghcHK| MlK2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCEQT;GN{Bk\WyuczDlfJBz\XO|aX7nJHRmdC2VSEOtV2gzNUuGIHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHH0JFUhfG9iMUCgeW0h[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODh6IN88UU4> Mkm2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2MUW4OlMoRjF4NEG1PFY{RC:jPh?=
BA/F3 MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoTmOFghcHK| MmrvS5Jwf3SqIHnubIljcXSrb36gc4YhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yC5aXzkMZR6eGViQnPyMWFjdCCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yOEmg{txONg>? NVi1VHlDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1OlIzOTdpPkK2OVYzOjF5PD;hQi=>
K562 M{LLfGZ2dmO2aX;uJIF{e2G7 MonxN|AhdWmwcx?= NIn6XmtKdmirYnn0bY9vKG:oIHvpco9j\WGmIHLpcoRqdmdidH:gSGRTOSCrbjDoeY1idiCNNU[yJINmdGy|IHnuZ5Vj[XSnZDDmc5IhOzBibXnud{BjgSCrVGLBVUBz\WGpZX70MYJie2WmIH3hd5Mhe3CnY4Tyc41mfHKrYzDt[ZRpd2RuIFnDOVAhRSByLkC5JO69VS5? MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ6MEK2NUc,Ojh{OECyOlE9N2F-
Ba/F3 M1;UO2Z2dmO2aX;uJIF{e2G7 MmXyOFghcHK| NUfieJlCUW6qaXLpeIlwdiCxZjD3bYxlKHS7cHWgRmNTNUGETEGgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hdW:3c3WgRoEwTjNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOFghcHK|IHL5JGJzcXSnTHnnbJQhdHWlaX\ldoF{\SCjc4PhfUwhT0l3MDC9JFAvODlyNTFOwG0v Mor0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzM{e5PFEoRjNyMUO3PVgyRC:jPh?=
BA/F3 NWfTb2x3S3m2b4TvfIlkcXS7IHHzd4F6 NGHsdog1QCCqcoO= NYTVZVlsS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNidILhcpNn\WO2ZXSge4l1cCC5aXzkJJR6eGViQnPyMWFjdCCjZoTldkA1QCCqcoOgZpkhYFSWIHHzd4F6NCCLQ{WwJF0hOC5yOUKg{txONg>? MonQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MEC4NFYoRjJ|NkCwPFA3RC:jPh?=
GIST882 MXTGeY5kfGmxbjDhd5NigQ>? NFuyboFKdmirYnn0bY9vKG:oIHj1cYFvKEuLVDDheZRweGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJGdKW1R6OEKgZ4VtdHNiYomgSWxKW0FuIFnDOVAhRSByLkC5O{DPxE1w NHnrcWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO|U{QCd-MkC4NVc2Ozh:L3G+
GIST882 NWS0[ZN6TnWwY4Tpc44h[XO|YYm= NXzhXpBCUW6qaXLpeIlwdiCxZjDLTXQhUzZ2MlWgcZV1[W62IHH1eI9xcG:|cHjvdplt[XSrb36gLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hcHWvYX6gS2lUXDh6MjDj[YxteyCkeTDFUGlUSSxiSVO1NEA:KDBwMEm3JO69VS5? M{TsblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkGxO|cyLz5{M{[xNVc4OTxxYU6=
insect M1;OTWZ2dmO2aX;uJIF{e2G7 MnPQN|AhdWmwcx?= MXzJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KHerbHSgeJlx\SCDQlyxJIV5eHKnc4Pl[EBqdiCrboPlZ5Qh[2WubIOgZYZ1\XJiM{CgcYlveyCkeTDGVmVVKGG|c3H5MEBKSzVyIE2gNE4xQTh{IN88UU4> NWrke4FiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN|AyPzB|PD;hQi=>
K562 MoTPR5l1d3SxeHnjbZR6KGG|c3H5 MX:3NkBpenN? NUWxcJg6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCwMlEh|ryPLh?= NUjFR25PRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
primary leukemia cells NHy3enVEgXSxdH;4bYNqfHliYYPzZZk> NVTXe2N3PzJiaILz M2HhOGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJBzcW2jcomgcIV2c2WvaXGgZ4VtdHNiaYPvcIF1\WRiZoLvcUBi[3W2ZTDtfYVtd2mmIHzleYtmdWmjIIDheIlmdnRiZYjwdoV{e2mwZzD3bYxlKHS7cHWgSmxVOyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhdHWlaX\ldoF{\SCjc4PhfUwhUUN3MDC9JFAvOSEQvF2u NXv2[oRlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNlEzODFpPkKyNlIyOjBzPD;hQi=>
BV173 MXPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mo\JOFghcHK| MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKYMUezJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCFZXzsMXRqfGW{LVfsc{BtfW2rbnXzZ4VvfCClZXzsJJZq[WKrbHn0fUBie3OjeTygS2k2OCB;IECuNUDPxE1w Mn;rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUGxOVkoRjJ5MEGxNVU6RC:jPh?=
BAF3 NXXJN2N6TnWwY4Tpc44h[XO|YYm= NEPIbmo4OiCqcoO= MW\Jcohq[mm2aX;uJI9nKFSnbD3meZNm\CClS1nUJGw2PjeSIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvM2NEUzhiYYPzZZktKEeLNUCgQUAxNjFizszNMi=> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
K562 M1zpVGN6fG:2b4jpZ4l1gSCjc4PhfS=> MWSyOEBpenN? NWTYc2wzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5zIN88UU4> NIrNPWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[zNlk{PSd-MkK2N|I6OzV:L3G+
BA/F3 NWXNRXlZTnWwY4Tpc44h[XO|YYm= M2fEVFczKGi{cx?= MWnJcohq[mm2aX;uJI9nKFSHTD3meZNm\CCSRFfGVoJmfGFiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W|ZTDCRU9HOyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxiZ4Lve5RpKGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JG1VWyCjc4PhfUwhT0l3MDC9JFAvOTB{IN88UU4> MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BAF3 Mk\nSpVv[3Srb36gZZN{[Xl? M4rxRVczKGi{cx?= Mn;yTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiYz3LTXQhVDV5NmCgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJGJCTjNiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25ibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONODDhd5NigSxiR1m1NEA:KDBwMUCyJO69VS5? NYLO[JRHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GIST882 MoSxRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeLU2S4PFIh[2WubIOsJGlEPTBiPTCwMlExQCEQvF2u MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzN{WzPEc,OjB6MUe1N|g9N2F-
GIST882 NXHPTZJ1TnWwY4Tpc44h[XO|YYm= NFnFT2lKdmirYnn0bY9vKG:oIFvJWEBMPjR{RTDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gbJVu[W5iR1nTWFg5OiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KEGWUD3k[ZBt\XSrb36gZZN{[XluIFnDOVAhRSByLkGwPEDPxE1w NED5XJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xNVc4OSd-MkO2NVE4PzF:L3G+
K562 M2HJ[2N6fG:2b4jpZ4l1gSCjc4PhfS=> M1nkSGN6fG:2b4jpZ{Bm\m[nY4SgbY4hUzV4MjDj[YxteyxiSVO1NEA:KDBwMUGg{txONg>? M4XV[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OUWxNVE{Lz5zMkm1NVEyOzxxYU6=
KU812 MX7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MnO1O|IhcHK| Ml7iRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNVUixNkBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzsJJRqfGW{LXfsc{Bie3OjeTygS2k2OCB;IECuNVEh|ryPLh?= MmO4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
BA/F3 MkLvRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M3fabFczKGi{cx?= MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy|IHX4dJJme3OrbnegRoNzNUGkbDDIN|k3WCCvdYThcpQh[W[2ZYKgO|IhcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOC5zMTFOwG0v Mny4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ|MEi4OlQ1RC:jPh?=
BAF3 NUXzcmtwTnWwY4Tpc44h[XO|YYm= NF[4SFc4OiCqcoO= M1HRVWlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIFPTSlFTKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIFLBSlMh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44hdWWjc4Xy[YQh[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMQCCjc4PhfUwhT0l3MDC9JFAvOTFizszNMi=> NUDwPXZxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
32D MkHGRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M3XKVlQ5KGi{cx?= M{Tq[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViM{LEJINmdGy|IITyZY5{\mWldHXkJJdqfGhicEKxNEBk\WyuczDlfJBz\XO|aX7nJGJkei2jYnygZZN{\XO|ZXSgZZMheHKxbHnm[ZJifGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD6xNVIh|ryPLh?= MnzDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2MUW4OlMoRjF4NEG1PFY{RC:jPh?=
insect cells MYLGeY5kfGmxbjDhd5NigQ>? M4jIV|MxKG2rboO= Mnr3TY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCDQlyxJG0{PTGWIH31eIFvfCCneIDy[ZN{\WRiaX6gbY5{\WO2IHPlcIx{KGGodHXyJFMxKG2rboOgZpkhTlKHVDDhd5NigSxiSVO1NEA:KDBwMUG0N{DPxE1w NFTSU3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
insect cells M2TU[mZ2dmO2aX;uJIF{e2G7 NWfXVmtFOzBibXnudy=> M1qz[WlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiQVLMNUBSOjV{SDDteZRidnRiZYjwdoV{e2WmIHnuJIlve2WldDDj[YxteyCjZoTldkA{OCCvaX7zJIJ6KE[URWSgZZN{[XluIFnDOVAhRSByLkGxOUDPxE1w NELj[pE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
K562 NYLOdpVSSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NXPxPYFJPzJiaILz NEmyfXRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGJEWi2DQlyg[IVx\W6mZX70JIh2dWGwIFu1OlIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT|gh[XO|YYmsJGdKPTBiPTCwMlEzKM7:TT6= MnrGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O|A2RC:jPh?=
BA/F3 M{fpNGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mn7CO|IhcHK| NV;NdVgxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhVTJ2NG[gcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IECuNVI6KM7:TT6= NFHlSWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C4PFY1PCd-MkOwPFg3PDR:L3G+
K562 MlTuRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MVq3NkBpenN? NWXWTXl4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG|c3H5MEBIUTVyIE2gNE4yPCEQvF2u NIK2d4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
HEK293 Ml\1SpVv[3Srb36gZZN{[Xl? NGmyUGJKdmirYnn0bY9vKG:oIHH1eI9xcG:|cHjvdplt[XSrb36gc4YhTESUMjDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IHL5JGVNUVODLDDJR|UxKD1iMD6xOFEh|ryPLh?= NITXNno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO|U{QCd-MkC4NVc2Ozh:L3G+
K562 NHrkZ3JCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MVy3NkBpenN? MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkh[2WubDD0bZRmei2pbH:gZZN{[XluIFfJOVAhRSByLkG0O{DPxE1w NVG3cYtkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1OFE3QTVpPkK4OVQyPjl3PD;hQi=>
BAF3 NFfEcVJHfW6ldHnvckBie3OjeR?= MlrKO|IhcHK| M3S2OmlvcGmkaYTpc44hd2ZiVFXMMYZ2e2WmIHPLTXQhSTh{OWCgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3ncI8h[XO|YYmsJGdKPTBiPTCwMlE1QDJizszNMi=> NHrkN2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
Ba/F3 NVzad4xvTnWwY4Tpc44h[XO|YYm= M3HGVlQ5KGi{cx?= NESxWnJKdmirYnn0bY9vKG:oIFLDVk1CSkxzIFWzOVVIKG23dHHueEApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCvb4Xz[UBD[S:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEKFUj3BRmwyNW2nZHnheIVlKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkA1QCCqcoOgZpkhSnKrdHXMbYdpfCCudXPp[oVz[XOnIHHzd4F6NCCJSUWwJF0hOC5zNEmg{txONg>? M4LTO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUO3PVgyLz5|MEGzO|k5OTxxYU6=
KU812 NV3yVnNqSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M{TyNlczKGi{cx?= MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEuXOEGyJINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFSz24JIF{e2G7LDDHTVUxKD1iMD6xOkDPxE1w NVvSU5VQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3PFk2PTNpPkK2O|g6PTV|PD;hQi=>
KU812 M3LjVmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NG\5WWI4OiCqcoO= NUHJ[2FXSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBDS1JvQVLMJIRmeGWwZHXueEBpfW2jbjDLWVgyOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFAvOTZizszNMi=> MmjiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O|A2RC:jPh?=
A10 MYjGeY5kfGmxbjDhd5NigQ>? MkLOOlghcHK| NEnjUZBKdmirYnn0bY9vKG:oIGDES2ZTNWKndHGg[JJqfmWwIIDyc4xq\mW{YYTpc44hd2ZicnH0JGEyOCClZXzsd{Bi\nSncjC2PEBpenNiaX6gdJJme2WwY3Wgc4YhemG2IILlZ49u[mmwYX70JHBFT0ZvQlKgZpkh[2WubDD0bZRmei2pbH:gcJVucW6nc3PlcoNmKGG|c3H5MEBKSzVyIE2gNE4yPjJizszNMi=> NUnae5JmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1NFI4ODBpPkK3OVAzPzByPD;hQi=>
KU812 NYjVcopESW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NVvqbVU4PzJiaILz NGXkcY1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFvVPFEzKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT|gh[XO|YYmsJGdKPTBiPTCwMlE3OyEQvF2u NXHEWIp4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
K562 MX\DfZRwfG:6aXPpeJkh[XO|YYm= M2TRbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMtKEmFNUCgQUAxNjF5IN88UU4> MoXGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MEC4NFYoRjJ|NkCwPFA3RC:jPh?=
K562 M4HD[WFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NHrwZphCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOsJGdKPTBiPTCwMlE4KM7:TT6= NXnkZ3o6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N|k3PzRpPkKyOFM6Pjd2PD;hQi=>
insect cells NEDiWlRHfW6ldHnvckBie3OjeR?= MUizNEBucW6| M4PCcWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiQVLMNUBJOzl4UDDteZRidnRiZYjwdoV{e2WmIHnuJIlve2WldDDj[YxteyCjZoTldkA{OCCvaX7zJIJ6KE[URWSgZZN{[XluIFnDOVAhRSByLkG3N|kh|ryPLh?= M{HCSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{CxO|A{Lz5{M{OwNVcxOzxxYU6=
K562 NWXncnNLS3m2b4TvfIlkcXS7IHHzd4F6 NYnRSXRxS3m2b4TvfIlkcXS7IHHnZYlve3RiS{W2NkBk\WyuczDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjF6IN88UU4> Mo\ZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3N{KwPFgoRjF5NUeyNFg5RC:jPh?=
K562 Mn:zRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NWq4dHl{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBMPTZ{IHPlcIx{NCCLQ{WwJF0hOC5zOEKg{txONg>? NX3OXmlMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[zN|I1PDBpPkG2N|MzPDRyPD;hQi=>
32D MVzDfZRwfG:6aXPpeJkh[XO|YYm= NWq4[3Z5S3m2b4TvfIlkKGGldHn2bZR6KGGpYXnud5QhdW:3c3WgN|JFKGOnbHzzJJRz[W6|ZnXjeIVlKHerdHigdFIyOCCEY4KtZYJtNCCLQ{WwJF0hOC5zOTFOwG0v MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjRzNUi2N{c,OTZ2MUW4OlM9N2F-
BA/F3 NEXNbHhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXvrO4lQPDhiaILz NHLOd4NCdnSrcILvcIln\XKjdHnvckBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LXHicEBie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4yQSEQvF2u NW\KfW1lRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NVU5PjNpPkG2OFE2QDZ|PD;hQi=>
BA/F3 M1nw[GFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NHrvW|I1QCCqcoO= M3S4VmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOgeJJidnOoZXP0[YQhf2m2aDDwNlExKEKlcj3hZowh[XO|ZYPz[YQh[XNicILvcIln\XKjdHnvckBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4yQSEQvF2u M4DCUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
BA/F3 NEH0W4FHfW6ldHnvckBie3OjeR?= M4rmT|czKGi{cx?= M37aZ2lvcGmkaYTpc44hd2ZiS3n0JIV5d25iOTDBXVUxOiC2bzC1NFMhcW6|ZYL0bY9vKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMD6xPVIh|ryPLh?= MoD0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
32D M3Pjd2Z2dmO2aX;uJIF{e2G7 NFP6Z4tKdmirYnn0bY9vKG:oIHj1cYFvKEKFUj3BRmwyKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIH3veZNmKDN{RDDj[YxteyxiSVO1NEA:KDBwMUm0JO69VS5? M4\oW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkGxO|cyLz5{M{[xNVc4OTxxYU6=
K562 MU\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NH3jTGc1QCCqcoO= M1PiSGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB2ODDodpMh[nliQ3XscE1VcXSncj3HcI8hdHWvaX7ld4NmdnRiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGdKPTBiPTCwMlIh|ryPLh?= NYHLdWZ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVEyPTlpPkK3NFEyOTV7PD;hQi=>
Ba/F3 NVj1WXFsTnWwY4Tpc44h[XO|YYm= NWP5SHhGPDhiaILz NXTqWXM6UW6qaXLpeIlwdiCxZjDCR3IuSUKOMTDFOFU6UyCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSmFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCEQ2KtRWJNOS2vZXTpZZRm\CClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPDhiaILzJIJ6KEK{aYTlUIlocHRibIXjbYZmemG|ZTDhd5NigSxiR1m1NEA:KDBwMkCxJO69VS5? M1LzVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUO3PVgyLz5|MEGzO|k5OTxxYU6=
BA/F3 NWe4UJprTnWwY4Tpc44h[XO|YYm= NU\5dHNpPzJiaILz NFW3eoJKdmirYnn0bY9vKG:oIFvpeEBmgG:wIEGxJIRmdGW2aX;uJEg2PTdidH:gOVU5KHKnc3nkeYV{MSCjbnSgSFgzOEFibYX0ZY51KGGwZDDEPFIxSSCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OCB;IECuNlE3KM7:TT6= NXTORlNqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
Sf9 MUPGeY5kfGmxbjDhd5NigQ>? M1HCcGlvcGmkaYTpc44hd2ZiaIXtZY4hVHmwIHvpcoF{\SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzMEBKSzVyIE2gNE4zOiEQvF2u MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN5Nk[4NEc,OTd|N{[2PFA9N2F-
K562 Mnz0RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Mn;TOFghcHK| Ml;tRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGy|IHHmeIVzKDR6IHjyd{BjgSC2conwZY4h[my3ZTDkfYUh\XilbIXzbY9vKGG|c3H5MEBKSzVyIE2gNE4zOiEQvF2u M3fiWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkK5PFU6Lz5{Nk[yPVg2QTxxYU6=
Ba/F MUfGeY5kfGmxbjDhd5NigQ>? M1K5d2lvcGmkaYTpc44hd2ZiYYX0c5Bpd3OyaH;yfYxifGmxbjDv[kBDS1JvQVLMNUBmgHC{ZYPz[YQhcW5iQnGvSkBk\WyuczygTWM2OCB;IECuNlIyKM7:TT6= NXrod|A1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
BA/F3 MVLGeY5kfGmxbjDhd5NigQ>? NUHoW5ZNUW6qaXLpeIlwdiCxZjDoeY1idiCEQ2KtRWJNOSCjdYTvdIhwe3Cqb4L5cIF1cW:wIHX4dJJme3OnZDDpckBud3W|ZTDCRU9HOyClZXzsd{BjgSCHTFnTRUwhUUN3MDC9JFAvOjJzIN88UU4> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzMUe3NUc,OjN4MUG3O|E9N2F-
BA/F3 M{npUGZ2dmO2aX;uJIF{e2G7 Mnu3O|IhcHK| NHvZTFZKdmirYnn0bY9vKG:oIFvpeEBmgG:wIEGxJIRmdGW2aX;uJEg2PTdidH:gOVU5KHKnc3nkeYV{MSCjbnSgUlgzOktibYX0ZY51KGGwZDDZPFI{TCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OCB;IECuNlI{KM7:TT6= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
SF9 NVvEZYhwTnWwY4Tpc44h[XO|YYm= MXOxJIhz NWnhVFAyUW6qaXLpeIlwdiCxZjDDMZRmem2rbnHsJGhqey22YXfn[YQhcHWvYX6gRWJNOSCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhcW6oZXP0[YQhW0Z7IHPlcIx{KHW|aX7nJHR6eiByMjDw[ZB1cWSnIHHzJJN2[nO2cnH0[UBu\WG|dYLl[EBi\nSncjCxJIhzKGK7IF\SSXQh[mG|ZXSgXkdNgXSnIHHzd4F6NCCLQ{WwJF0hOC5{MkOg{txONg>? MnT6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
NCI-H1703 M3jEdGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NVzDeHhWPzJiaILz NEfzOlRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JOTdyMzDj[YxteyCjZoTldkA4OiCqcoOgbY4heHKnc3XuZ4Uhd2ZiUFTHSk1CSSCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG|c3H5MEBIUTVyIE2gNE4zOyEQvF2u M{HWcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUS0NVQ6Lz5{OUW0OFE1QTxxYU6=
CHO NEf6ZllHfW6ldHnvckBie3OjeR?= MoHLTY5pcWKrdHnvckBw\iC5aXzkJJR6eGViUHzheIVt\XRvZHXybZZm\CCpcn;3eIgh\mGldH;yJJJm[2WydH;yJIJmfGFicHjvd5Bpd3K7bHH0bY9vKGmwIFPIU{Bk\WyuczygTWM2OCB;IECuNlQh|ryPLh?= MmDsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJzNk[5OVAoRjF{MU[2PVUxRC:jPh?=
MEG01 Mn;4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M1\3c|czKGi{cx?= Mn;rRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRVewNUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1utPEBie3OjeTygS2k2OCB;IECuNlQh|ryPLh?= M3PqOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{i5OVU{Lz5{Nke4PVU2OzxxYU6=
BA/F3 NXPSe5dPS3m2b4TvfIlkcXS7IHHzd4F6 MXe3NkBpenN? MmDxR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yCEQ2KtRWJNKE1|NUHUJI12fGGwdDDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUCgQUAxNjJ2IN88UU4> M2\kWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{CxO|A{Lz5{M{OwNVcxOzxxYU6=
K562 M4LOZWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mn;IRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGy|LDDJR|UxKD1iMD6yOFQh|ryPLh?= MnPnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N|goRjJyOEG3OVM5RC:jPh?=
Ba/F3 NICzU|VHfW6ldHnvckBie3OjeR?= NHzzNYw1QCCqcoO= MmjSTY5pcWKrdHnvckBw\iCEQ2KtRWJNOSCIM{W5WkBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hdW:3c3WgRoEwTjNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBDS1JvQVLMNU1u\WSrYYTl[EBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOFghcHK|IHL5JGJzcXSnTHnnbJQhdHWlaX\ldoF{\SCjc4PhfUwhT0l3MDC9JFAvOjR7IN88UU4> MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF|N{m4NUc,OzBzM{e5PFE9N2F-
K562 MUnGeY5kfGmxbjDhd5NigQ>? NXHUb4kyOzBibXnudy=> NYnEZYVjUW6qaXLpeIlwdiCxZjDrbY5w[mWjZDDibY5lcW6pIITvJGFDVCCrbjDoeY1idiCNNU[yJINmdGy|IHnuZ5Vj[XSnZDDmc5IhOzBibXnud{BjgSCrVGLBVUBz\WGpZX70MYJie2WmIH3hd5Mhe3CnY4Tyc41mfHKrYzDt[ZRpd2RuIFnDOVAhRSByLkK1JO69VS5? MljrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OECyOlEoRjJ6MkiwNlYyRC:jPh?=
M07e M4nkS2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MkjwOFghcHK| NHm0ZmRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF2wO4UhSmO{LXHicEBv\WejdHn2[UBk\WyuczDlfJBz\XO|aX7nJJN1\W1iY3XscEBn[WO2b4KgZZN{\XO|ZXSgZZMheHKxbHnm[ZJifGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD6yOVch|ryPLh?= NYW0doIyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NVU5PjNpPkG2OFE2QDZ|PD;hQi=>
CHO MoXTSpVv[3Srb36gZZN{[Xl? M37RU2lvcGmkaYTpc44hd2ZiY3jpcYVzcWNiUFTHSkBz\WOncITvdkB4cXSqIHOtb4l1KGO7dH;wcIF{dWmlIHTvcYFqdiCyaH;zdIhwenmuYYTpc44hcW5iQ1jPJINmdGy|LDDJR|UxKD1iMD6yOkDPxE1w M1XVSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{MU[2PVUxLz5zMkG2Olk2ODxxYU6=
EM2 NFXJfGlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MnToOFghcHK| M1rMbmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRV2yJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCFZXzsMXRqfGW{LVfsc{BtfW2rbnXzZ4VvfCClZXzsJJZq[WKrbHn0fUBie3OjeTygS2k2OCB;IECuNlYh|ryPLh?= NEK5Xpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxNVE2QSd-MkewNVEyPTl:L3G+
K562 NHrJO2VCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Mk\rO|IhcHK| MYrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONODDhd5NigSxiR1m1NEA:KDBwMk[3JO69VS5? MmX5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
BAF3 MX\GeY5kfGmxbjDhd5NigQ>? Mo\DO|IhcHK| NHzRWodKdmirYnn0bY9vKG:oIHj1cYFvKEKFUj;BRmwheDJzMDDmeZNqd25icILveIVqdiCneIDy[ZN{\WRiaX6gRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0t6IHHzd4F6NCCJSUWwJF0hOC5{NzFOwG0v MlXKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
K562 NFfP[VZHfW6ldHnvckBie3OjeR?= NWiwNoc2OzBibXnudy=> M1Tpe2lvcGmkaYTpc44hd2Zia3nuc4Jm[WRiYnnu[Ilv\yC2bzDBVmchcW5iaIXtZY4hUzV4MjDj[YxteyCrbnP1ZoF1\WRiZn;yJFMxKG2rboOgZpkhcVSUQWGgdoVi\2WwdD3iZZNm\CCvYYPzJJNx\WO2cn;t[ZRzcWNibXX0bI9lNCCLQ{WwJF0hOC5{N{Kg{txONg>? MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ6MEK2NUc,Ojh{OECyOlE9N2F-
KBM5 NWjoUFNsS3m2b4TvfIlkcXS7IHHzd4F6 MVi3NkBpenN? Mo\xR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2JOPSClZXzsd{Bp[XKkb4Lpcochf2muZDD0fZBmKEKlcj3BZowh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOjhizszNMi=> MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2OU[2OUc,OjBzNEm2OlU9N2F-
K562 MlTsRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MnjHO|IhcHK| NX3NW3JWSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKEKlcj3BZowh[W[2ZYKgO|IhcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOC5{ODFOwG0v Mn;jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzOUWxN|YoRjJ4MUm1NVM3RC:jPh?=
HEK293 M3:3[WZ2dmO2aX;uJIF{e2G7 NHS0SIxKdmirYnn0bY9vKG:oIHH1eI9xcG:|cHjvdplt[XSrb36gc4YhS1OIMWKg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDifUBGVEmVQTygTWM2OCB;IECuNlkyKM7:TT6= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzN{WzPEc,OjB6MUe1N|g9N2F-
Sf9 NXXGXYpqTnWwY4Tpc44h[XO|YYm= MWHJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IFHicEBscW6jc3WgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hW2Z7IHPlcIx{KHW|aX7nJGdITUGLWVHBVGZMUyCjczDzeYJ{fHKjdHWgbY4heHKnc3XuZ4Uhd2ZiW3fhcY1iOzOSXVHUVEwhUUN3MDC9JFAvOyEQvF2u M1HaXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkixPVg3Lz5{NE[4NVk5PjxxYU6=
K562 NWfIXpB{S3m2b4TvfIlkcXS7IHHzd4F6 MnT1O|IhcHK| MmfmR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT|U3OiClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IGjUWEBie3OjeTygTWM2OCB;IECuN|Eh|ryPLh?= NEna[Ho9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{KxOFUyOid-MkeyNVQ2OTJ:L3G+
BA/F3 MUDGeY5kfGmxbjDhd5NigQ>? NYPW[lBlPzJiaILz MWPJcohq[mm2aX;uJI9nKEurdDDlfI9vKDFzIHTlcIV1cW:wIDi1OVchfG9iNUW4JJJme2mmdXXzLUBidmRiQUiyPXAhdXW2YX70JIFv\CC\OEKzSEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwM{GyJO69VS5? M1XtUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5|MEKwOFQ1OTxxYU6=
ALL3 NWLUUpY3S3m2b4TvfIlkcXS7IHHzd4F6 NUTDVI5iS3m2b4TvfIlkcXS7IHHnZYlve3RiUHjpcIFl\WyyaHnhJINpem:vb4PvcYUheG:|aYTpeoUhcHWvYX6gRWxNOyClZXzsd{BjgSCDbHHtZZIhSmy3ZTDmcJVwemW|Y3XueEBie3OjeTygTWM2OCB;IECuN|M{KM7:TT6= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTh6OUW0NEc,OTl6OEm1OFA9N2F-
KU812 NY\u[JpmSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NXPIWVF1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLWVgyOiClZXzsd{whUUN3MDC9JFAvOzN5IN88UU4> NWnGdHRLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzO|Y2QDdpPkKxN|c3PTh5PD;hQi=>
BA/F3 NFnHcIxCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MkTyOFghcHK| MWjBcpRqeHKxbHnm[ZJifGmxbjDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy|IHX4dJJme3OrbnegRoNzNWGkbDDBN|M4ViCvdYThcpQh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOzN7IN88UU4> NY\sdIpPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NVU5PjNpPkG2OFE2QDZ|PD;hQi=>
CML NUfYUGRuSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NIrFb4hCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPNUEBk\WyuczygTWM2OCB;IECuN|Uh|ryPLh?= MlPxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{MUmwNVYoRjF7MkG5NFE3RC:jPh?=
HEK293 NFvOdXdHfW6ldHnvckBie3OjeR?= NHX0[FkyNjVibXnudy=> MUXJcohq[mm2aX;uJI9nKGi3bXHuJG1CXEV{Sz3t[YRq[XSnZDDBV3AsKHWydHHr[UBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJJVxKHSxIEWwNEB2VSCjZoTldkAyNjVibXnud{BjgSCobIXvdoV{[2WwY3WgZZN{[XluIFnDOVAhRSByLkO1JO69VS5? M{LBOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MkSxNFI6Lz5{M{K0NVAzQTxxYU6=
HEK293 NY\sPYk1TnWwY4Tpc44h[XO|YYm= MW[xMlUhdWmwcx?= MV7Jcohq[mm2aX;uJI9nKGi3bXHuJG1CXEVzLX3l[IlifGWmIFHTVEshfXC2YXvlJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZYZ1\XJiMT61JI1qdnNiYomg[ox2d3Knc3PlcoNmKGG|c3H5MEBKSzVyIE2gNE4{PSEQvF2u Ml;OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{NEGwNlkoRjJ|MkSxNFI6RC:jPh?=
M-NFS-60 M3nIcWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MljCRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCPLV7GV{03OCClZXzsd{whUUN3MDC9JFAvOzV6IN88UU4> NEnWTGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO|U{QCd-MkC4NVc2Ozh:L3G+
insect cells MYXGeY5kfGmxbjDhd5NigQ>? Mn6zN|AhdWmwcx?= MlvMTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCDQlyxJGczPTCHIH31eIFvfCCneIDy[ZN{\WRiaX6gbY5{\WO2IHPlcIx{KGGodHXyJFMxKG2rboOgZpkhTlKHVDDhd5NigSxiSVO1NEA:KDBwM{W5PUDPxE1w M{HmbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{CxO|A{Lz5{M{OwNVcxOzxxYU6=
BA/F3 NEDLVnRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MnfpO|IhcHK| NGLVZnNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LVHicEBGOzV3RzDteZRidnRiYX\0[ZIhPzJiaILzJIJ6KEOFSz24JIF{e2G7LDDJR|UxKD1iMD6zOlIh|ryPLh?= M4X6XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
BA/F3 MkfsSpVv[3Srb36gZZN{[Xl? M4nlU|czKGi{cx?= MoiwTY5pcWKrdHnvckBw\iCWRVyt[pV{\WRiYz3LTXQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO|YYmsJGdKPTBiPTCwMlM4KM7:TT6= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2NEG0PUc,Ojl3NESxOFk9N2F-
BAF3 NXfvToNnTnWwY4Tpc44h[XO|YYm= NFuyNnVKdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDjMWtKXCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDCRWY{KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKG2nYYP1doVlKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUzhiYYPzZZktKEeLNUCgQUAxNjN5IN88UU4> M2[1VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
K562 M1TreWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NFvjVnBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOsJGlEPTBiPTCwMlM5KM7:TT6= MnrnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|N{[1PFcoRjJzM{e2OVg4RC:jPh?=
K562 MmDBRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NIXNSpc4OiCqcoO= NH\6R2VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKHO3co\peoFtKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjN6IN88UU4> NHrKUlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nki1NFAxPCd-Mk[4OVAxODR:L3G+
BA/F3 M4XOdGZ2dmO2aX;uJIF{e2G7 MXq3NkBpenN? NFrUS4FKdmirYnn0bY9vKG:oIFLDVk9CSkxicEKxNEApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1utPEBie3OjeTygS2k2OCB;IECuN|gh|ryPLh?= NYfsTWo5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3PFk2PTNpPkK2O|g6PTV|PD;hQi=>
BAF3 MonBSpVv[3Srb36gZZN{[Xl? NUnhc5p{PzJiaILz NGS3WVdKdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDjT2lVKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkh[2WubDD0bZRmei2pbH:gZZN{[XluIFfJOVAhRSByLkO4NVkh|ryPLh?= MoHiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
K562 NWLsUHNYS3m2b4TvfIlkcXS7IHHzd4F6 M3K0N|Q5KHSxIEeyJIhzew>? NVvFcGVIS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSkOULVHCUEBxd3OrdHn2[UBMPTZ{IHPlcIx{KGGodHXyJFQ5KHSxIEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlM5PDRizszNMi=> Mn7zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5OEm0NlkoRjJ{N{i5OFI6RC:jPh?=
K562 MVvDfZRwfG:6aXPpeJkh[XO|YYm= NEHCTFk4OiCqcoO= NXLEfohnS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCJSUWwJF0hOC5|OTFOwG0v M4DtelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUOyN|E{Lz5{MkmzNlMyOzxxYU6=
BA/F3 MYrGeY5kfGmxbjDhd5NigQ>? MV:3NkBpenN? NHzlSXRKdmirYnn0bY9vKG:oIFvpeEBmgG:wIEGxJIRmdGW2aX;uJEg2PTdidH:gOVU5KHKnc3nkeYV{MSCjbnSgWlY2PEFibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGdKPTBiPTCwMlM6OiEQvF2u MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BA/F3 NHzuRpVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MkiyOUB1dyBzMDD1US=> M1T5OFQ5KGi{cx?= NUPuNGlNSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKE6STT3hZowh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[XRiNTD0c{AyOCC3TTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD6zPVMh|ryPLh?= MmPJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2MUW4OlMoRjF4NEG1PFY{RC:jPh?=
K562 NVHINI16TnWwY4Tpc44h[XO|YYm= NF[4VoNKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhcHWvYX6gT|U3OiClZXzsd{Boem:5dHigeZNqdmdiTWTUJIF{e2G7LDDJR|UxKD1iMD60JO69VS5? MmruQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR3NUK3OlAoRjF2NUWyO|YxRC:jPh?=
BAF3 NWjnZWdbTnWwY4Tpc44h[XO|YYm= NXzMco04PzJiaILz NGDjNndKdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDjT2lVKCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFAvPCEQvF2u NXfC[XlqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|c4ODVpPkK3NFc4PzB3PD;hQi=>
BA/F3 M{jZWWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M2nYVlczKGi{cx?= M1SxVGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW|c3nu[{BD[3JvQXLsJG0{PTGWIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSByLkSyOEDPxE1w NXzSbWpqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
KCL22 M{npUmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MWi0PEBpenN? NWnIUlh6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLR2wzOiClZXzsd{Bi\nSncjC0PEBpenNiYomgR4VtdC2WaYTldk1IdG9ibIXtbY5me2OnboSgZ4VtdCC4aXHibYxqfHliYYPzZZktKEeLNUCgQUAxNjR|IN88UU4> M4LNelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEGxNVU6Lz5{N{CxNVE2QTxxYU6=
Ba/F3 MX7GeY5kfGmxbjDhd5NigQ>? MoXSOFghcHK| NULaRpd1UW6qaXLpeIlwdiCxZjDCR3IuSUKOMTDRNlUzUCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSmFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCEQ2KtRWJNOS2vZXTpZZRm\CClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPDhiaILzJIJ6KEK{aYTlUIlocHRibIXjbYZmemG|ZTDhd5NigSxiR1m1NEA:KDBwNEW1JO69VS5? M4TTZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUO3PVgyLz5|MEGzO|k5OTxxYU6=
Sf9 NFnhOoZHfW6ldHnvckBie3OjeR?= M4XzdGlvcGmkaYTpc44hd2ZiaIXtZY4hSWKuIHvpcoF{\SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzMEBKSzVyIE2gNE41PyEQvF2u M{PkOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{e2OlgxLz5zN{O3OlY5ODxxYU6=
K562 MlHzR5l1d3SxeHnjbZR6KGG|c3H5 M1j0dVQ5KGi{cx?= MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjR5IN88UU4> NG[ydnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ezOVgzPid-MkO3N|U5OjZ:L3G+
K562 NGSx[HlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M4XxUVQ5KGi{cx?= NHO3cHRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuOFch|ryPLh?= MnuxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5N{i3OlYoRjJ3N{e4O|Y3RC:jPh?=
K562 NX;1d4xNTnWwY4Tpc44h[XO|YYm= MmizTY5pcWKrdHnvckBw\iCEQ2KtRWJNOSCjdYTvdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIFu1OlIh[2WubIOsJGlEPTBiPTCwMlQ4OyEQvF2u NVXzU49WRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
insect cells M3PzNWZ2dmO2aX;uJIF{e2G7 NUHTN4ZNOzBibXnudy=> NGHwbGFKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFHCUFEhTTJ3NVugcZV1[W62IHX4dJJme3OnZDDpckBqdnOnY4SgZ4VtdHNiYX\0[ZIhOzBibXnud{BjgSCIUlXUJIF{e2G7LDDJR|UxKD1iMD60PFU5KM7:TT6= Ml7GQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MEG3NFMoRjJ|M{CxO|A{RC:jPh?=
Sf9 M{LRSWZ2dmO2aX;uJIF{e2G7 NHPodnRDcW6maX7nJIFn\mmwaYT5JJRwKGi3bXHuJJJmdW:2ZTDzbZRmKG:oIF6teIVzdWmwYXygbIV5[Wirc4Tp[Ilv\S22YXfn[YQhSUKOMjDlfJBz\XO|ZXSgbY4hXHKrY3jvdIx2e2mjIH7pJIlv\mWldHXkJHNnQSClZXzsd{BjgSCrc3;0bIVzdWGuIITpeJJifGmxbjDjZYxwemmvZYTybYMh[XO|YYmsJGtlKD1iMD61JO69VS5? M4jHOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEG3N|Q{Lz5{MUSxO|M1OzxxYU6=
primary leukemia cells NVn3[nNDS3m2b4TvfIlkcXS7IHHzd4F6 NUD6Zm9OPzJiaILz NUn5fnV3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4heHKrbXHyfUBt\XWtZX3pZUBk\WyuczDpd49t[XSnZDDmdo9uKGGldYTlJI16\WyxaXSgcIV2c2WvaXGgdIF1cWWwdDDlfJBz\XO|aX7nJGZNXDNvREizOXkhdXW2YYTpc44h[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JIx2[2moZYLhd4Uh[XO|YYmsJGlEPTBiPTCwMlUh|ryPLh?= Mlq1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MkGyNFEoRjJ{MkKxNlAyRC:jPh?=
BA/F3 MofDSpVv[3Srb36gZZN{[Xl? MV63NkBpenN? M{HjO2lvcGmkaYTpc44hd2ZiVFXMMWxEUyBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3MDC9JFAvPSEQvF2u NWfQT4FURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3PFk2PTNpPkK2O|g6PTV|PD;hQi=>
K562 MnjiRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M3fmeWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczygTWM2OCB;IECuOUDPxE1w M3fSU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{WyOFg{Lz5{M{O1NlQ5OzxxYU6=
K562 NELK[YZEgXSxdH;4bYNqfHliYYPzZZk> M3fEbFczKGi{cx?= NGCyOHBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFczKGi{czDifUBk[WylZXnuMWFOKGG|c3H5MEBKSzVyIE2gNE42KM7:TT6= M33Id|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUixOVMzLz5{M{m4NVU{OjxxYU6=
K562 NHHYd2FEgXSxdH;4bYNqfHliYYPzZZk> NGnRXog4OiCqcoO= MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyC3c3nu[{BE[WylZXnuJGFOKGK7IH\seY9z\XOlZX7j[UBie3OjeTygTWM2OCB;IECuOUDPxE1w NG\PfZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe1O|YxOyd-MkW3OVc3ODN:L3G+
K562 Mo\aR5l1d3SxeHnjbZR6KGG|c3H5 MWHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzMEBKSzVyIE2gNE42KM7:TT6= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF6OU[3OEc,OjdzOEm2O|Q9N2F-
BA/F3 M4PZbWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUi0fXZ4PzJiaILz M3;lemN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z|IHPlcIx{KGW6cILld5Nqdmdid3ns[EB1gXCnIFLDVk1CSkxiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPDT{05KGG|c3H5MEBKSzVyIE2gNE42KM7:TT6= M3L4clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{CxO|A{Lz5{M{OwNVcxOzxxYU6=
K562 M4Kxc2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 M2HYRVQ5KGi{cx?= MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwNTFOwG0v MmTFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7M{KwO|EoRjJ|OUOyNFcyRC:jPh?=
Sf9 MVfGeY5kfGmxbjDhd5NigQ>? MXnUVH9VWkGQU2DPVnRGWjpiaX7obYJqfGmxbjDv[kBCXFCjc3WgZYN1cX[rdImgbY4hSkOUUD3lfJBz\XO|aX7nJHNnQSClZXzsd{whUUN3MDC9JFAvPSEQvF2u M2\Vb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MUW1PFQyLz5zNUG1OVg1OTxxYU6=
K562 MWTDfZRwfG:6aXPpeJkh[XO|YYm= Mkm3O|IhcHK| MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlUyKM7:TT6= M2TNSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OEG0PFkxLz5{NkixOFg6ODxxYU6=
K562 NWLBW4I1S3m2b4TvfIlkcXS7IHHzd4F6 M{HzNVQ5KGi{cx?= M1j0ZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvPTNizszNMi=> NGDzXnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkewO|g1Pid-Mk[3NFc5PDZ:L3G+
K562 Ml3KRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NWHSPHI4PDhiaILz NUXNb5k6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlU{KM7:TT6= NH:5UXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEWyOVg{QCd-Mki1NlU5Ozh:L3G+
BA/F3 NXW3PHFHTnWwY4Tpc44h[XO|YYm= NW\F[Gp1PzJiaILz M1vvR2lvcGmkaYTpc44hd2ZiS3n0JIV5d25iMUGg[IVt\XSrb36gLFU2PyC2bzC1OVghemW|aXT1[ZMqKGGwZDDEPFE3UCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OCB;IECuOVM2KM7:TT6= M1HzVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5|MEKwOFQ1OTxxYU6=
BA/F3 MkXlSpVv[3Srb36gZZN{[Xl? M4HPflczKGi{cx?= NHXEbFNKdmirYnn0bY9vKG:oIGDES2ZT[WyyaHGgWlU3OURxREi0NnYhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkW2O{DPxE1w MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
K562 MmTOR5l1d3SxeHnjbZR6KGG|c3H5 NGDrfmk1QCCqcoO= MY\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlU5KM7:TT6= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ7NUO4NEc,OjF{OUWzPFA9N2F-
BA/F3 NXzrT|NTS3m2b4TvfIlkcXS7IHHzd4F6 Mmn5O|IhcHK| NF\hcVREgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiRUO1PXYhdXW2YX70JIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDBwNUmg{txONg>? MnnMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MEG3NFMoRjJ|M{CxO|A{RC:jPh?=
BA/F3 NX3S[|Z7TnWwY4Tpc44h[XO|YYm= NWP0epB1PzJiaILz M2D3PWlvcGmkaYTpc44hd2ZiQlPSM2FDVCCyMkGwMW0{PTGWIH31eIFvfCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3MDC9JFAvPjJ3IN88UU4> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
BAF3 MkTSSpVv[3Srb36gZZN{[Xl? NYjYWpRPPzJiaILz Mn3oTY5pcWKrdHnvckBw\iCEQ2KvRWJNKHB{MUCg[pV{cW:wIIDyc5RmcW5iTUO1OnQhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLPEBie3OjeTygS2k2OCB;IECuOlI2KM7:TT6= NUj4b4JHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
BA/F3 MlTTSpVv[3Srb36gZZN{[Xl? M{W1SVczKGi{cx?= MYLJcohq[mm2aX;uJI9nKEKFUj;BRmwheDJzMD3RNlUzUCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO|YYmsJGdKPTBiPTCwMlY2QSEQvF2u MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
BA/F3 M1\pfWZ2dmO2aX;uJIF{e2G7 MVG3NkBpenN? M33LN2lvcGmkaYTpc44hd2ZiS3n0JIV5d25iMUGg[IVt\XSrb36gLFU2PyC2bzC1OVghemW|aXT1[ZMqKGGwZDDZPFI{TCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OCB;IECuOlY6KM7:TT6= NX;uTmdCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BA/F3 NE\3V3ZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MYXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFLDVk1CSkxzIITyZY5{\mWldHXkJI1wfXOnIFLBM2Y{KGOnbHzzMEBKSzVyIE2gNE43PzhizszNMi=> NWnjV5o3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
BA/F3 MXrGeY5kfGmxbjDhd5NigQ>? Ml7JTY5pcWKrdHnvckBw\iCqdX3hckBDS1JvQVLMNUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCkeTDBWHAu\GWybHX0bY9vKGG|c3H5MEBKSzVyIE2gNE43PzhizszNMi=> Ml7qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUG3O|EoRjJ|NkGxO|cyRC:jPh?=
K562 NGr5XYtCeG:ydH;zbZMh[XO|YYm= MUS0PEBpenN? MlH6TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCNNU[yJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCjbn7lfIlvXiCjbnSgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZzDiZZNm\CCobH;3JIN6fG:vZYTyfUwhSUN3MDC9JFAvPjhizszNMi=> MmPVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4Mkm4OVkoRjJ4NkK5PFU6RC:jPh?=
BA/F3 M1LxVmZ2dmO2aX;uJIF{e2G7 MoPwO|IhcHK| MVjJcohq[mm2aX;uJI9nKEurdDDWOVYxTC:YNkW0RUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwN{CxJO69VS5? M1i4T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5|MEKwOFQ1OTxxYU6=
K562 NH;hTmtEgXSxdH;4bYNqfHliYYPzZZk> M2nCRlczKGi{cx?= NF3SWWdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBndHWxcnXzZ4Vv[2VibXnjdo9xdGG2ZTDy[YFl\XJibXX0bI9lNCCLQ{WwJF0hOC55MzFOwG0v NVi0T|lKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3OFE5PTNpPkK2O|QyQDV|PD;hQi=>
BAF3 M1j5bmZ2dmO2aX;uJIF{e2G7 MUK3NkBpenN? M{f6XGlvcGmkaYTpc44hd2ZiQVLMJIlvKG2xdYPlJGJCTjNiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkezJO69VS5? M37kflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUe0N|M5Lz5{OEm3OFM{QDxxYU6=
insect cells NHzmTFVHfW6ldHnvckBie3OjeR?= NV7pdHYzOzBibXnudy=> NUnURmpqUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDBRmwyKFl{NUPGJI12fGGwdDDlfJBz\XO|ZXSgbY4hcW6|ZXP0JINmdGy|IHHmeIVzKDNyIH3pcpMh[nliRmLFWEBie3OjeTygTWM2OCB;IECuO|Q6PiEQvF2u MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN|MEG3NFM9N2F-
K562 MYLGeY5kfGmxbjDhd5NigQ>? M4D4PFIhcHK| MVTJcohq[mm2aX;uJI9nKEKFUj;BRmwheDJzMDDheZRweGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgNkBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{NCCLQ{WwJF0hOC55NTFOwG0v NYe1Z4RoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxPFg2PzlpPkKwNVg5PTd7PD;hQi=>
BAF3 MmfPSpVv[3Srb36gZZN{[Xl? MkC0O|IhcHK| NHXmcIxKdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDjT2lVKFZ3NUnEM3Y3PTSDIHTveYJt\SCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkGIMzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBk\WyuIITpeIVzNWeubzDhd5NigSxiR1m1NEA:KDBwOECzJO69VS5? NEexepg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
BAF3 NVzEWFJRTnWwY4Tpc44h[XO|YYm= NEL1OFU4OiCqcoO= M2jI[WlvcGmkaYTpc44hd2ZiVFXMMYZ2e2WmIHPLTXQhXjZ3NFGgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3ncI8h[XO|YYmsJGdKPTBiPTCwMlgxOzFizszNMi=> Ml;oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
Ba/F3 MULGeY5kfGmxbjDhd5NigQ>? NX:xOFZpPDhiaILz Mo[yTY5pcWKrdHnvckBw\iCEQ2KtRWJNOSC\MkWzTEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hdW:3c3WgRoEwTjNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBDS1JvQVLMNU1u\WSrYYTl[EBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOFghcHK|IHL5JGJzcXSnTHnnbJQhdHWlaX\ldoF{\SCjc4PhfUwhT0l3MDC9JFAvQDN4IN88UU4> M4T5PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUO3PVgyLz5|MEGzO|k5OTxxYU6=
Ba/F3 MmXnSpVv[3Srb36gZZN{[Xl? NVLMeYdjPDhiaILz MkjxTY5pcWKrdHnvckBw\iCEQ2KtRWJNOSCHMkW1T{BufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hdW:3c3WgRoEwTjNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBDS1JvQVLMNU1u\WSrYYTl[EBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOFghcHK|IHL5JGJzcXSnTHnnbJQhdHWlaX\ldoF{\SCjc4PhfUwhT0l3MDC9JFAvQDN6IN88UU4> NUTxN3dHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxN|c6QDFpPkOwNVM4QThzPD;hQi=>
BAF3 M1u0VGZ2dmO2aX;uJIF{e2G7 MXO3NkBpenN? Mm\qTY5pcWKrdHnvckBw\iCEQ2KvRWJNKHB{MUCg[pV{cW:wIIDyc5RmcW5iRkOxO2khdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLPEBie3OjeTygS2k2OCB;IECuPFUh|ryPLh?= Mne1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
BA/F3 NUjvV4hxTnWwY4Tpc44h[XO|YYm= M2LN[FczKGi{cx?= NX;Hc3FFUW6qaXLpeIlwdiCxZjDCR3IwSUKOIICyNVAuTjNzN1mgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUy16IHHzd4F6NCCJSUWwJF0hOC56NUWg{txONg>? NGDxbpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
Ba/F3 M2r3e2Z2dmO2aX;uJIF{e2G7 MmnKOFghcHK| M2\5T2lvcGmkaYTpc44hd2ZiQlPSMWFDVDFiRUK1OXYhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKG2xdYPlJGJiN0Z|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhSkOULVHCUFEudWWmaXH0[YQh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBDemm2ZVzp[4h1KGy3Y3nm[ZJie2ViYYPzZZktKEeLNUCgQUAxNjh5NDFOwG0v M3PXSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUO3PVgyLz5|MEGzO|k5OTxxYU6=
Sf9 MVPGeY5kfGmxbjDhd5NigQ>? M{DpT3RRZ1SUQV7TVG9TXEWUOjDl[oZtfXhib3[gTI9m[2i|dEOzN|QzKGmwIFLDVnAu\XiycnXzd4lv\yCVZkmgZ4VtdHNuIFnDOVAhRSByLkmg{txONg>? NF2y[Yw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUG1OVg1OSd-MUWxOVU5PDF:L3G+
CHO M4X1cmZ2dmO2aX;uJIF{e2G7 MUXJcohq[mm2aX;uJI9nKGOqaX3ldolkKFCGR1[gdoVk\XC2b4Kge4l1cCCFU1[tNXIh[3m2b4DsZZNucWNiZH;tZYlvKHCqb4PwbI9zgWyjdHnvckBqdiCFSF:gZ4VtdHNuIFnDOVAhRSByLkm2JO69VS5? NYjOeooyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKxOlY6PTBpPkGyNVY3QTVyPD;hQi=>
BA/F3 NXzpVFZPSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MV:3NkBpenN? NWO4PYdVSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhTjN3OW[gcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IECuPVYh|ryPLh?= NXvuXJFyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
BA/F3 NEn3OXNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M{\mc|Q5KGi{cx?= MW\BcpRqeHKxbHnm[ZJifGmxbjDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy|IHX4dJJme3OrbnegRoNzNWGkbDDBN|M1dCCvdYThcpQh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvQTZ{IN88UU4> M{X6SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
K562 M1LkWWN6fG:2b4jpZ4l1gSCjc4PhfS=> NVLIRW5wOjRiaILz MmqzR5l1d3SxeHnjbZR6KGGpYXnud5QhcW2jdHnubYIue2Wwc3n0bZZmKGi3bXHuJGs2PjJiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOjRiaILzJIJ6KFiWVDDhd5NigSxiSVO1NEA:KDFizszNMi=> Mn7oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{NkG0OlgoRjNyMk[xOFY5RC:jPh?=
BA/F3 NH3qcmZEgXSxdH;4bYNqfHliYYPzZZk> NV3xbnFZPzJiaILz M{PMWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z|IHPlcIx{KGW6cILld5NqdmdiQlPSMWFDVCCINEi2V{BufXSjboSgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOSEQvF2u NILtd3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
GIST430 Mkj2R5l1d3SxeHnjbZR6KGG|c3H5 MmnEO|IhcHK| MWLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDHTXNVPDNyIHPlcIx{KGijcnLvdolv\yCNSWSgWlY2PEFibYX0ZY51KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTldmdtdyCjc4PhfUwhT0l3MDC9JFEvOSEQvF2u MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl7MUS2OUc,Ojh7OUG0OlU9N2F-
K562 NHfUXYZEgXSxdH;4bYNqfHliYYPzZZk> M{D3blQ5KGi{cx?= MmnRR5l1d3SxeHnjbZR6KGmwIHTyeYche2Wwc3n0bZZmKGi3bXHuJGs2PjJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgOFghcHK|IHL5JHhVXCCjc4PhfUwhUUN3MDC9JFEvOSEQvF2u NEDFRlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[1OVk5OSd-Mkm2OVU6QDF:L3G+
IR-K562 M3TIWGN6fG:2b4jpZ4l1gSCjc4PhfS=> MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBqdWG2aX7pZkBz\XOrc4ThcpQhcHWvYX6gTXIuUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImsJGlEPTBiPTCxMlEh|ryPLh?= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ4NEWwN{c,OjZ{NkS1NFM9N2F-
K562 MnfDRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NXq3SYxWPDhiaILz NEDQ[2tCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGuNVYh|ryPLh?= MlrqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{M{GwO|koRjJ4MkOxNFc6RC:jPh?=
K562 MXLDfZRwfG:6aXPpeJkh[XO|YYm= NH\yPFQ1QCCqcoO= MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIV5eHKnc4PpcochSmO{LVHicEBie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOS5zNjFOwG0v NGrDfoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS1NVc4Oid-Mk[0OVE4PzJ:L3G+
BA/F3 MWjGeY5kfGmxbjDhd5NigQ>? NETNZ4c4OiCqcoO= NVrLVmlDUW6qaXLpeIlwdiCxZjDLbZQhXjV4MFSvSFgyPkhibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGdKPTBiPTCxMlE6OSEQvF2u MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BAF3 NHrHSo5HfW6ldHnvckBie3OjeR?= M4jsWFczKGi{cx?= M17S[GlvcGmkaYTpc44hd2ZiVFXMMYZ2e2WmIHPLTXQhTDhzNligcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3ncI8h[XO|YYmsJGdKPTBiPTCxMlI1PSEQvF2u NVKwb3VIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1OFE3QTVpPkK4OVQyPjl3PD;hQi=>
FDC-P1 NH\wXYpHfW6ldHnvckBie3OjeR?= MmjJOFghcHK| NWPnWJBmUW6qaXLpeIlwdiCxZjDoeY1idiCITWOg[ZhxemW|c3XkJIlvKGe{b4f0bEBn[WO2b4Kg[IVx\W6mZX70JI1wfXOnIF\ER{1ROSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGZOWy2vZXTpZZRm\CClZXzsJJBzd2yrZnXyZZRqd25iaX6gdJJme2WwY3WgbJVu[W5iQ2PGNUBi\nSncjC0PEBpenNiYomgdoV{[Xq3cnnuJIR6\SC{ZXT1Z5Rqd25iYYPzZZktKEmFNUCgQUAyNjJ5NDFOwG0v NFv0bVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG1OlY5QSd-MkCxOVY3QDl:L3G+
BAF3 NUTCS3g1TnWwY4Tpc44h[XO|YYm= MnvzO|IhcHK| NVvaPYhxUW6qaXLpeIlwdiCxZjDU[Ywu\nW|ZXSgZ2tKXCCQOEKyT{BufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSUZ|IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMT6yPUDPxE1w M3HuU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O|A2Lz5{N{C3O|cxPTxxYU6=
BAF3 MWDGeY5kfGmxbjDhd5NigQ>? NW\KR2NXPzJiaILz M3XweGlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHOtT2lVKE56MkLLJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBDSUZ|IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFS{igZZN{[XluIFfJOVAhRSBzLkK5JO69VS5? NFnjW2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
BA/F3 M33YUWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1:zelczKGi{cx?= M3\WfmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW|c3nu[{BD[3JvQXLsJHkzPTOIIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSBzLkS0OEDPxE1w MoHFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ|MEi4OlQ1RC:jPh?=
BAF3 NUG5WJhnTnWwY4Tpc44h[XO|YYm= MlvLO|IhcHK| MX3Jcohq[mm2aX;uJI9nKFSHTD3meZNm\CClS1nUJG45OjKNIH31eIFvfCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQV[zJINmdGy|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHygeIl1\XJvZ3zvJIF{e2G7LDDHTVUxKD1iMT60OlYh|ryPLh?= NGLIcVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
BA/F3 NIDuZm1HfW6ldHnvckBie3OjeR?= MUS3NkBpenN? NYjVephDUW6qaXLpeIlwdiCxZjDLbZQh\XixbjCxNUBl\WyndHnvckApPTZyIITvJFU4QCC{ZYPp[JVmeylibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGdKPTBiPTCxMlUzOyEQvF2u M1;DSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5|MEKwOFQ1OTxxYU6=
BA/F3 NWf3TmlnS3m2b4TvfIlkcXS7IHHzd4F6 NWO5[VVPPzJiaILz M4my[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z|IHPlcIx{KGW6cILld5NqdmdiQlPSMWFDVCCHM{W1S{BufXSjboSgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOS54IN88UU4> MkixQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MEG3NFMoRjJ|M{CxO|A{RC:jPh?=
BA/F3 NWXvVpRjTnWwY4Tpc44h[XO|YYm= NInvbnk4OiCqcoO= MX;Jcohq[mm2aX;uJI9nKEKFUj;BRmwheDJzMD3IN|Y6WCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO|YYmsJGdKPTBiPTCxMlY6KM7:TT6= NGDON2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
GIST882 NVjCWYt1SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NXrLN5hbQTZiaILz NWH0XWFISW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHTXNVQDh{IHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUAyNjdizszNMi=> MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTR4OUW0O{c,OTl2Nkm1OFc9N2F-
GIST882 NUjiSYpVSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NIHaU5U6PiCqcoO= NFf5NJZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIlu[XSrbnniMZN2e2OncITpZoxmKGi3bXHuJGdKW1R6OEKgZ4VtdHNiaHHyZo9zcW6pIHOtT2lVKEt4NELFJI12fGGwdDDh[pRmeiB7NjDodpMh[nliU2LCJIF{e2G7LDDJR|UxKD1iMT63JO69VS5? NUDCfmhXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm3NlQ3PTNpPkK5O|I1PjV|PD;hQi=>
BAF3 MofOSpVv[3Srb36gZZN{[Xl? NHztUHc4OiCqcoO= MnvHTY5pcWKrdHnvckBw\iCEQ2KvRWJNKHB{MUCg[pV{cW:wIIDyc5RmcW5iSEO2PXAhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLPEBie3OjeTygS2k2OCB;IEGuO|kh|ryPLh?= NIr1RYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
BA/F3 MoLQRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M2rnZ|czKGi{cx?= NVHIS4FmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKHerbHSgeJlx\SCEY4KtRYJtKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDFwOEO0JO69VS5? NW[yXoRyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
BA/F3 NHHCWnlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NGnXcZI4OiCqcoO= M1SwN2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW|c3nu[{BD[3JvQXLsJGczPTCHIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSBzLki2N{DPxE1w MoizQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ|MEi4OlQ1RC:jPh?=
BA/F3 NYnnN5VHTnWwY4Tpc44h[XO|YYm= MkPuO|IhcHK| NX3vZppvUW6qaXLpeIlwdiCxZjDCR3IwSUKOIICyNVAuTTJ3NVugcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUy16IHHzd4F6NCCJSUWwJF0hOS57MzFOwG0v M1TJVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{i5OVU{Lz5{Nke4PVU2OzxxYU6=
BA/F3 MonWSpVv[3Srb36gZZN{[Xl? NF;F[XY4OiCqcoO= NX30emoxUW6qaXLpeIlwdiCxZjDUSWwuW1KFIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUy16IHHzd4F6NCCJSUWwJF0hOi5zIN88UU4> M1fFWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{i5OVU{Lz5{Nke4PVU2OzxxYU6=
NCI-H1703 NWDHfXlMSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MlzJO|IhcHK| NYrmZZV6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDF5MEOgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONLUigZZN{[XluIFfJOVAhRSB{LkGg{txONg>? M1LLVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUS0NVQ6Lz5{OUW0OFE1QTxxYU6=
BAF3 MlfYSpVv[3Srb36gZZN{[Xl? MnLaO|IhcHK| NXr1UXJTUW6qaXLpeIlwdiCxZjDCR3IwSUKOIICyNVAh\nW|aX;uJJBzd3SnaX6gSlMyP0xibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIFLBSlMh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44hdWWjc4Xy[YQh[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMQCCjc4PhfUwhT0l3MDC9JFIvOTZizszNMi=> MkXxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
BA/F3 NYW0fo9PTnWwY4Tpc44h[XO|YYm= MnjKO|IhcHK| M3u4emlvcGmkaYTpc44hd2ZiQlPSM2FDVCCyMkGwMWY{OTeOIH31eIFvfCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3MDC9JFIvOTZ7IN88UU4> NHnQd4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
BA/F3 NFW4UWpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NVjabWpZPzJiaILz Mo\hRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCEQT;GN{Bk\WyuczDlfJBz\XO|aX7nJGJkei2DYnygTFM6PlJibYX0ZY51KGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDJwM{e3JO69VS5? NYeyTHhYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
HGC27 NUH1Z2V1SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MWS5OkBpenN? NHPaRpJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjHR|I4KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCyMlQh|ryPLh?= M1v0fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NE[5OVQ4Lz5zOUS2PVU1PzxxYU6=
HGC27 NEftN5FCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MXu5OkBpenN? NHzlOVVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjHR|I4KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCyMlQh|ryPLh?= M1PPUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7N{K0OlU{Lz5{OUeyOFY2OzxxYU6=
BAF3 NFPIS4dHfW6ldHnvckBie3OjeR?= MWi3NkBpenN? NFLiTI1KdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDjT2lVKFZ4NUTBJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJCTjNiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCCycn;sbYZmemG2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtfGm2ZYKt[4xwN0OFS{igZZN{[XluIFfJOVAhRSB{LkS5JO69VS5? NHTGe5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O|cxPSd-MkewO|c4ODV:L3G+
BAF3 NXvRVpBDTnWwY4Tpc44h[XO|YYm= NIW3RnQ4OiCqcoO= NXfOZ2V{UW6qaXLpeIlwdiCxZjDU[Ywu\nW|ZXSgZ{1MUVRiVk[1OGEhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLPEBie3OjeTygS2k2OCB;IEKuOFkh|ryPLh?= NEjqT|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
BA/F3 MkfDRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Mk\xO|IhcHK| NFnxUWRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LVHicEBHPDh4UzDteZRidnRiYX\0[ZIhPzJiaILzJIJ6KEOFSz24JIF{e2G7LDDJR|UxKD1iMj61OFch|ryPLh?= NX;aTGp7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
BA/F3 NIrOPHhHfW6ldHnvckBie3OjeR?= MX[3NkBpenN? MlLDTY5pcWKrdHnvckBw\iCNaYSg[ZhwdiB7IFHZOVAzKHSxIEWwN{BqdnOncoTpc44h[W6mIFS4NVYhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSB{Lke0PUDPxE1w Mmn6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
HEK293 MnfDSpVv[3Srb36gZZN{[Xl? MnvYNU42KG2rboO= M4[2b2lvcGmkaYTpc44hd2ZiaIXtZY4hVUGWRULLMY1m\GmjdHXkJGFUWCtidYD0ZYtmKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[W[2ZYKgNU42KG2rboOgZpkh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwJF0hOi57IN88UU4> NIDLbYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K0NVAzQSd-MkOyOFExOjl:L3G+
BA/F3 NVuydXJ1SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NFrve4Y4OiCqcoO= NXPaeHBESW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhTTJ3NVugcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IEKuPVUyKM7:TT6= M4OwOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
BA/F3 NWDQTYlWTnWwY4Tpc44h[XO|YYm= MUO3NkBpenN? NFPzPW1KdmirYnn0bY9vKG:oIGTFUE1FTFJzIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUy16IHHzd4F6NCCJSUWwJF0hOyEQvF2u MkfnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm1OVMoRjJ4N{i5OVU{RC:jPh?=
BAF3 NVWzfGlTTnWwY4Tpc44h[XO|YYm= M1zDUVczKGi{cx?= M33yeGlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHPLTXQhXjV3OVSvWlY2PEFiZH;1ZoxmKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT|gh[XO|YYmsJGdKPTBiPTCzJO69VS5? NWjpe4NHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|c4ODVpPkK3NFc4PzB3PD;hQi=>
BAF3 NEf2WZRHfW6ldHnvckBie3OjeR?= MWC3NkBpenN? M1TYbGlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHOtT2lVKFZ3NUnEM3Y3PTSDIHTveYJt\SCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBu\WG|dYLl[EBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2s5KGG|c3H5MEBIUTVyIE2gN{DPxE1w MmnLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
BA/F3 M3j0T2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NFm0NJY4OiCqcoO= NHjhOIJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LVHicEBVOzF3STDteZRidnRiYX\0[ZIhPzJiaILzJIJ6KEOFSz24JIF{e2G7LDDJR|UxKD1iMz6wNFUh|ryPLh?= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB6OE[0OEc,OjNyOEi2OFQ9N2F-
BA/F3 MYnDfZRwfG:6aXPpeJkh[XO|YYm= M3rRVVczKGi{cx?= M4XnOGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z|IHPlcIx{KGW6cILld5NqdmdiQlPSMWFDVCCIM{G3UEBufXSjboSgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOy5|IN88UU4> NUnFdG1zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN|AyPzB|PD;hQi=>
MDCK NIHISZhHfW6ldHnvckBie3OjeR?= NVL5VIRTUW6qaXLpeIlwdiCxZjDCR3JRKGW6cILld5Nm\CCrbjDNSGNMKGOnbHzzJIJ6KHCqZX;wbI9z[mmmZTDBJIF{e2G7LDDJR|UxKD1iMz6zPEDPxE1w MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl|Mkm2NEc,OTl7M{K5OlA9N2F-
K562 NVrofJBoSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MXq3NkBpenN? M3vCcGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMz60N{DPxE1w MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ6NEewPEc,Ojl4OES3NFg9N2F-
BA/F3 NFzpVZBEgXSxdH;4bYNqfHliYYPzZZk> MkHpO|IhcHK| NV\COoRJS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDCR3IuSUKOIGGyOVJJKG23dHHueEBie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSB|Lk[g{txONg>? MlPGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MEG3NFMoRjJ|M{CxO|A{RC:jPh?=
BA/F3 M37zVWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVK3NkBpenN? MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy|IHX4dJJme3OrbnegRoNzNUGkbDDRNlUzUCCvdYThcpQh[W[2ZYKgO|IhcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOy55NkOg{txONg>? M2jId|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
HGC27 MnTBR5l1d3SxeHnjbZR6KGG|c3H5 NIjEUpQ1QCCqcoO= MofaR5l1d3SxeHnjbZR6KGGpYXnud5QhUEeFMkegZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDNwODFOwG0v MnXPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MEC1PFQoRjJ2OUCwOVg1RC:jPh?=
BA/F3 MUDGeY5kfGmxbjDhd5NigQ>? M2CyV|czKGi{cx?= MV;Jcohq[mm2aX;uJI9nKEurdDDlfI9vKDliQWm1NFIhfG9iNUCzJIlve2W{dHnvckBidmRiVk[1OEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDNwOUS3JO69VS5? NGPpd3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
MCF7 MX M4flWGZ2dmO2aX;uJIF{e2G7 M4TrSWlvcGmkaYTpc44hd2ZiQlPSVEBmgHC{ZYPz[YQhcW5iTVPGO{BOYCClZXzsd{BjgSCKb3XjbJN1KDN|M{SyJJN1[WmwaX7nMEBKSzVyIE2gOE4xPyEQvF2u M2DlWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUOyPVYxLz5zOUmzNlk3ODxxYU6=
BA/F3 NIrrNpVHfW6ldHnvckBie3OjeR?= NYK2ZpJGPzJiaILz MUPJcohq[mm2aX;uJI9nKFSHTD3CUGshMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO|YYmsJGdKPTBiPTC0MlEh|ryPLh?= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
K562 M{mye2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mn7qOFghcHK| M1WwcWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgRoNzN0GkbDDwc5NqfGm4ZTDoeY1idiCNNU[yJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgcYV1cG:mLDDJR|UxKD1iND6xNkDPxE1w MnH5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2NkS4PFYoRjJ3NE[0PFg3RC:jPh?=
K562 MXnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M1TsZ|Q5KGi{cx?= MkfvRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2LkGyJO69VS5? M2ficlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4Mkm4OFk2Lz5{NkK5PFQ6PTxxYU6=
HEK293 MlXpSpVv[3Srb36gZZN{[Xl? MnXKN{BucW6| M{C3ZmlvcGmkaYTpc44hd2ZiaIXtZY4hV0OWMj3t[YRq[XSnZDDBV3AsKHWydHHr[UBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJIFnfGW{IEOgcYlveyCkeTDmcJVwemW|Y3XuZ4Uh[XO|YYmsJGlEPTBiPTC0MlIh|ryPLh?= NYTwOpdPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOFExOjlpPkKzNlQyODJ7PD;hQi=>
A549 NYS0OYZYSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NWPuTYtNPDhiaILz M4nyWGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iND61OkDPxE1w NUjJSFZvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1NlU5OzhpPkK4OVI2QDN6PD;hQi=>
K562/G NVzJ[nZNS3m2b4TvfIlkcXS7IHHzd4F6 NHPqbWo4OiCqcoO= MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzN0diY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQvPjVizszNMi=> M1XjRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OEG0PFkxLz5{NkixOFg6ODxxYU6=
BAF3 MWTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M{LuWlczKGi{cx?= NYXrOI1zSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCRWY{KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG|c3H5MEBIUTVyIE2gOE43QDZizszNMi=> NIrKcm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
BA/F3 M1zpb2N6fG:2b4jpZ4l1gSCjc4PhfS=> MnPvOFghcHK| M1frUGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z|IHPlcIx{KHS{YX7z[oVkfGWmIIfpeIghSmO{LVHicEBVOzF3STDteZRidnRiYX\0[ZIhPDhiaILzJIJ6KFiWVDDhd5NigSxiSVO1NEA:KDRwN{mg{txONg>? M1vReFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkCwPFA3Lz5{M{[wNFgxPjxxYU6=
MCF7 NWXKPY8xTnWwY4Tpc44h[XO|YYm= MorXTY5pcWKrdHnvckBw\iCDQlPHNkBqdiCqdX3hckBucXSxeHHueJJwdmVvcnXzbZN1[W62IF3DSlch[2WubIOgZpkhUG:nY3jzeEA{OzN2MjDhd5NigSxiSVO1NEA:KDRwOEm3O|kh|ryPLh?= Mkm2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4N{i0PVUoRjF6Nke4OFk2RC:jPh?=
Sf9 M2rONmZ2dmO2aX;uJIF{e2G7 NU\w[FlnSmmwZHnu[{Bi\m[rbnn0fUB1dyC{ZXPvcYJqdmGwdDDmeYxtKGynbnf0bEBpfW2jbjDOMZRmem2rbnHsJGdUXC22YXfn[YQhW3mtLVvEJEg{PTZidH:gOlM2KHKnc3nkeYV{MSCleYTvdIxie22rYzDkc41icW5iZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKFOoOTDpcpNm[3RiY3XscJMhfXOrbnegdI9tgSCHWTC0PlEh[XNic4Xid5Rz[XSnLDDLbUA:KDVizszNMi=> MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF|Mke1Nkc,OjlzM{K3OVI9N2F-
insect cells MnLMSpVv[3Srb36gZZN{[Xl? NH3SZ5A{OCCvaX7z MXHJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEGETEGgWFMyPUlibYX0ZY51KGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMh[W[2ZYKgN|AhdWmwczDifUBHWkWWIHHzd4F6NCCLQ{WwJF0hPS5zNUWg{txONg>? NV;FR|lORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN|AyPzB|PD;hQi=>
BA/F3 NVntPVc2S3m2b4TvfIlkcXS7IHHzd4F6 MYS3NkBpenN? MmrBR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yCEQ2KtRWJNKEd{NUDFJI12fGGwdDDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUCgQUA2NjJizszNMi=> NGe3cFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
HEL MYLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M2XmPFczKGi{cx?= MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0tvODDhd5NigSxiR1m1NEA:KDVwMzFOwG0v M3vjV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{i5OVU{Lz5{Nke4PVU2OzxxYU6=
K562 M1zpZmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NWDFO|NGPDhiaILz MlX3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB3LkSg{txONg>? MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV5NkCyN{c,OjF3N{[wNlM9N2F-
KBM5 M4jaUmN6fG:2b4jpZ4l1gSCjc4PhfS=> NYLLeGtbPzJiaILz NXezUppyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hU0KPNTDj[YxteyCqYYLic5JqdmdiQnPyMWFjdCCWM{G1TUBufXSjboSgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEWuOEDPxE1w NX3VTG5JRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFk3PjVpPkKwNVQ6PjZ3PD;hQi=>
BA/F3 NET6ZpBEgXSxdH;4bYNqfHliYYPzZZk> MUO3NkBpenN? NVrQPXUzS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDCR3IuSUKOIFWyOVVMKG23dHHueEBie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSB3Lk[g{txONg>? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN|MEG3NFM9N2F-
BAF3 NHHlXHZHfW6ldHnvckBie3OjeR?= NUjSSYw3PzJiaILz M2rufGlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHPLTXQhXDZ5MFmvWlU2QURiZH;1ZoxmKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT|gh[XO|YYmsJGdKPTBiPTC2MlY4KM7:TT6= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
BAF3 M4K4bGZ2dmO2aX;uJIF{e2G7 MmTIO|IhcHK| MXPJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClLVvJWEBVPjdySTDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0t6IHHzd4F6NCCJSUWwJF0hPi54NzFOwG0v NUnSVIl5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
BA/F3 NIPwOJVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3y0OFczKGi{cx?= NWTNfotUSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3MDC9JFYvPyEQvF2u NVvtenNpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3PFk2PTNpPkK2O|g6PTV|PD;hQi=>
GIST48B M4D1RmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NV3jUoJpPzJiaILz M4[x[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1nTWFQ5SiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtKHSrdHXyMYdtdyCjc4PhfUwhT0l3MDC9JFYvQTh4IN88UU4> MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV2MU[5OUc,Ojh3NEG2PVU9N2F-
BaF3 MofDRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NH7idoZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI12emmwZTDCZWY{KGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKE6STT;BUGsh[nliW{PIYZRpgW2rZHnu[UB2eHSja3WgZZN{[XluIFnDOVAhRSB5LkGg{txONg>? NHH5TIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkm3NFQxOCd-MU[5O|A1ODB:L3G+
MCF7 NWnYPGQ{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NVXMeY1MPzJiaILz M3PaSGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNz6xNkDPxE1w MnHGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4OES3NFgoRjJ7Nki0O|A5RC:jPh?=
A2780 MWnGeY5kfGmxbjDhd5NigQ>? MUfJcohq[mm2aX;uJI9nKFBvZ4CgbY4hcHWvYX6gZYRzcWGveXPpck1z\XOrc4ThcpQhSTJ5OECgZ4VtdHNiYomgTI9m[2i|dDCzN|M1OiCjc4PhfUwhUUN3MDC9JFcvOjR2M{[g{txONg>? MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ5OES5OUc,OTh4N{i0PVU9N2F-
A2780/ADR NGDuPXlHfW6ldHnvckBie3OjeR?= NXyxUHE1UW6qaXLpeIlwdiCxZjDQMYdtgWOxcILveIVqdiCneIDy[ZN{\WRiaX6gRVI4QDBxQVTSJINmdGy|IHL5JINidGOnaX6gRW0h[XO|YYmsJGlEPTBiPTC3MlI1PDN4IN88UU4> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzh7MEC5OEc,OTd6OUCwPVQ9N2F-
BA/F3 MYPGeY5kfGmxbjDhd5NigQ>? MVW3NkBpenN? MU\Jcohq[mm2aX;uJI9nKFSHTD3ESHIzKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIH3veZNmKEKDL1[zJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG|c3H5MEBIUTVyIE2gO{44KM7:TT6= NEXWWYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
HEK293 M3XOTWN6fG:2b4jpZ4l1gSCjc4PhfS=> MorKR5l1d3SxeHnjbZR6KGGpYXnud5QhUEWNMkmzJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUwhS0N3MDC9JFgvPCEQvF2u MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ4NEWwN{c,OjZ{NkS1NFM9N2F-
FDC-P1 NH\QRmVHfW6ldHnvckBie3OjeR?= M4fNelQ5KGi{cx?= MXjJcohq[mm2aX;uJI9nKG2xdYPlJGdONUOVRj3zeIlufWyjdHXkJINmdGxicILvcIln\XKjdHnvckBw\iCpcn;3eIgh\mGldH;yJIRmeGWwZHXueEBud3W|ZTDGSGMuWDFiY3XscJMh\XiycnXzd4lv\yCqdX3hckBHVVNiYX\0[ZIhPDhiaILzJIJ6KHKnc3H6eZJqdiCmeXWgdoVlfWO2aX;uJIF{e2G7LDDJR|UxKD1iOD60N|ch|ryPLh?= M2P6c|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUW2Olg6Lz5{MEG1OlY5QTxxYU6=
BA/F3 Mo\RRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M{n2W|czKGi{cx?= NF\SdZdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LVHicEBGOjV3VjDteZRidnRiYX\0[ZIhPzJiaILzJIJ6KEOFSz24JIF{e2G7LDDJR|UxKD1iOD62NVUh|ryPLh?= M1PmW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
A2780 M2q0dGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1SwT|czKGi{cx?= M4\vVmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUK3PFAh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEiuPUDPxE1w NFnsc2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[4OFcxQCd-Mkm2PFQ4ODh:L3G+
BESM MUnBcpRqfHK7cHHuc5NwdWGuIHHzd4F6 M2Pzb|g5KGi{cx?= MXXBcpRqfHK7cHHuc5NwdWGuIHHjeIl3cXS7IHHnZYlve3RiVIL5dIFvd3OxbXGgZ5J2gmliYX3hd5Rq\2:2ZYOgbY5n\WO2ZXSgbY4hSkWVTTDj[YxteyCvZXHzeZJm\CCjZoTldkA5QCCqcoOgdI9{fGmwZnXjeIlwdiCkeTDIWHMh[XO|YYmsJGVEPTBiPTC5JO69VS5? M37FXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNUS3PFE6Lz5{MEW0O|gyQTxxYU6=
BaF3 MlXORY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NX\EUoZsSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBufXKrbnWgRoFHOyClZXzsd{BmgHC{ZYPzbY5oKE6STT;BUGshVDJ3NmSgcZV1[W62IHL5JHs{UF22aIntbYRqdmVidYD0ZYtmKGG|c3H5MEBKSzVyIE2gPU4yKM7:TT6= MkD1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ7N{C0NFAoRjF4OUewOFAxRC:jPh?=
BA/F3 MkHSR5l1d3SxeHnjbZR6KGG|c3H5 NGnkRlY4OiCqcoO= NUjPPXhJS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDCR3IuSUKOIGmyOVNHKG23dHHueEBie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSB7LkKg{txONg>? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN|MEG3NFM9N2F-
BA/F3 M3\NNmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDtc5V{\SCEQT;GN{Bk\WyuczDpckBxemW|ZX7j[UBw\iCrboTldoxmfWurbjCzMEBKSzVyIE2gPU41PTlizszNMi=> NVLiNppnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
BA/F3 NUXBZ5RIS3m2b4TvfIlkcXS7IHHzd4F6 M1P6ZlczKGi{cx?= NXz1ZYxOS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDCR3IuSUKOIF[zNVdXKG23dHHueEBie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSB7LkWg{txONg>? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN|MEG3NFM9N2F-
Ba/F3 MmH0SpVv[3Srb36gZZN{[Xl? NH3UcWY1QCCqcoO= M3zmVmlvcGmkaYTpc44hd2ZiQlPSMWFDVDFiVEOxOWkhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKG2xdYPlJGJiN0Z|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBDemm2ZVzp[4h1KGy3Y3nm[ZJie2ViYYPzZZktKEeLNUCgQUA6NjZ2NTFOwG0v M1PPeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUO3PVgyLz5|MEGzO|k5OTxxYU6=
BA/F3 NEDpdGNHfW6ldHnvckBie3OjeR?= MoHHO|IhcHK| MlnITY5pcWKrdHnvckBw\iCWRVytTGNMKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIH3veZNmKEKDL1[zJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG|c3H5MEBIUTVyIE2gPU44KM7:TT6= NXLhZYdxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3PFk2PTNpPkK2O|g6PTV|PD;hQi=>
BA/F3 Mo\hSpVv[3Srb36gZZN{[Xl? MlLCO|IhcHK| NUm0cYpGUW6qaXLpeIlwdiCxZjDLbZQhTDhzNm[gcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmEwTjNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFNiYYPzZZktKEeLNUCgQUA6Njl|IN88UU4> NX;kO|RrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
HCT116 NVL6U4RlS3m2b4TvfIlkcXS7IHHzd4F6 MYS3NkBpenN? M4XGV2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCxNEDPxE1w NVLvfZR7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
HepG2 NHTRRZBCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M4nnUFI1KHSxIEm2JIhzew>? MV\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDJ2IITvJFk3KGi{czDifUBOXFNiYYPzZZktKEmFNUCgQUAyOCEQvF2u Ml2yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7M{KwO|EoRjJ|OUOyNFcyRC:jPh?=
BA/F3 NHXYbJdEgXSxdH;4bYNqfHliYYPzZZk> MofMO|IhcHK| MkCwR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yCEQ2KtRWJNKEh|OU\SJI12fGGwdDDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUCgQUAyOS5zIN88UU4> Mkf2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MEG3NFMoRjJ|M{CxO|A{RC:jPh?=
MCF7 MlXTRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NIH4do06PiCqcoO= NVTrNYtXSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCxNU4{KM7:TT6= NXvZSpJKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm3NlQ3PTNpPkK5O|I1PjV|PD;hQi=>
MCF7 NYPFTYFwSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MYm5OkBpenN? NWHNOYNVSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCxNU42KM7:TT6= M3HPc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NE[5OVQ4Lz5zOUS2PVU1PzxxYU6=
RKOp21 NW\mbIRoS3m2b4TvfIlkcXS7IHHzd4F6 M{TWVlczKGi{cx?= MlTQR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVmtQeDJzIHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEGyJO69VS5? MoO2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
BA/F3 MWrDfZRwfG:6aXPpeJkh[XO|YYm= MUe3NkBpenN? NIS1[YtEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiTEK0PHYhdXW2YX70JIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDF{LkKg{txONg>? MlflQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MEG3NFMoRjJ|M{CxO|A{RC:jPh?=
BA/F3 M{jE[GN6fG:2b4jpZ4l1gSCjc4PhfS=> NHjpdFA4OiCqcoO= NHKzfmZEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiVEOxOWkhdXW2YX70JIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDF{LkKg{txONg>? NITseJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
BA/F3 MVXDfZRwfG:6aXPpeJkh[XO|YYm= NYXLN2FkPzJiaILz NHvoOXFEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiWUK1N2ghdXW2YX70JIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDF{LkWg{txONg>? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN|MEG3NFM9N2F-
RKOp21 MlPZR5l1d3SxeHnjbZR6KGG|c3H5 NFnxTmM4OiCqcoO= MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDST29xOjFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMUKuOVg6OiEQvF2u MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl|MEG5NFI9N2F-
K562 MlvoRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MWOyOEBpenN? MX;JckB3cXS{bzDhcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGzJO69VS5? M4Hx[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkixPVg3Lz5{NE[4NVk5PjxxYU6=
BA/F3 M3HwSGN6fG:2b4jpZ4l1gSCjc4PhfS=> MnXnO|IhcHK| NX7vdXBwS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPDT{05KGG|c3H5MEBKSzVyIE2gNVMvPSEQvF2u MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN|MEG3NFM9N2F-
U937 MWjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mmq5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDVPVM4KGOnbHzzMEBKSzVyIE2gNVQh|ryPLh?= NYrPRY5bRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[zN|I1PDBpPkG2N|MzPDRyPD;hQi=>
BA/F3 NWTYXJRLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH3IV3U1QCCqcoO= MVfHdo94fGhiaX7obYJqfGmxbjDv[kBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhXDNzNVmgcZV1[W62IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzND61JO69VS5? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV4MkKxO{c,OjZ3NkKyNVc9N2F-
A549 NHXnTHdEgXSxdH;4bYNqfHliYYPzZZk> NELnOYk4OiCqcoO= MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF3LkWg{txONg>? MmDyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
K562 NWTaUFR5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NU\LVnM4PDhiaILz MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHntZZRqdmmkLYLld4l{fGGwdDDoeY1idiCNNU[yJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzNT63JO69VS5? NX3zUIhFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yN|ExPzlpPkK2NlMyODd7PD;hQi=>
MDA-MB-468 NYrNeoUyS3m2b4TvfIlkcXS7IHHzd4F6 MV63NkBpenN? NH\HW4dEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtOFY5KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF3Lki0PFkh|ryPLh?= NUX6boZ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
KG1a NXXhNJR{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NH65T2w4OiCqcoO= NXX0cXZsSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLS|FiKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCC|dYL2bZZidCCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTZwNzFOwG0v MkLKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6NUCwNFQoRjJ4OEWwNFA1RC:jPh?=
MDA-MB-468 Mn\HR5l1d3SxeHnjbZR6KGG|c3H5 MUG3NkBpenN? NEjzRWNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtOFY5KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF5IN88UU4> NGTPO4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
HMC-1.2 M2PvXmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NVHaWXBDSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUWMuOS5{IHPlcIx{KGOjcoL5bY5oKFZ3NkDHMEBFQDF4VjDteZRidnRiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxO{DPxE1w MoTLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyMES0NFkoRjJ3MEC0OFA6RC:jPh?=
BA/F3 NWWxdmE6SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MYq3NkBpenN? M2ftd2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW|c3nu[{BD[3JvQXLsJHkzPTOKIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSBzNz6wPFMh|ryPLh?= M{PTfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
HUVEC MoH2RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NWLUcYNNSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBJXV[HQzDj[YxteyxiR1m1NEA:KDF6LkWg{txONg>? Mo\6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{m2O|QoRjJ{NEO5Olc1RC:jPh?=
BA/F3 Mkn5RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NWDLbYpvPzJiaILz MkfURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCEQT;GN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliQ1PLMVgh[XO|YYmsJGlEPTBiPTCxPE42OiEQvF2u M2rNelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
HeLa MWPDfZRwfG:6aXPpeJkh[XO|YYm= M4DCW|czKGi{cx?= NGG4TnVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEG4MlY2KM7:TT6= NE\KSYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
GIST48 MmfaR5l1d3SxeHnjbZR6KGG|c3H5 M{TiNlMhfG9iNjDkZZl{ M1THNGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGdKW1R2ODDj[YxteyCjc4Pld5Nm\CCjczDl[oZm[3Rib36gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOyC2bzC2JIRigXNiYomgcJVkcW[ncnHz[UBj[XOnZDDseY1qdmW|Y3XuZ4Uh[XO|YYmsJGlEPTBiPTCxPE44KM7:TT6= MorKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl2Nkm1OFcoRjF7NE[5OVQ4RC:jPh?=
Hec1A NXz2U5pHS3m2b4TvfIlkcXS7IHHzd4F6 NHvmUI44OiCqcoO= NXjMPII1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWlMVGgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGGuYX3hdk1jdHWnIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gNVkh|ryPLh?= NIPuOlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
U937 MXXDfZRwfG:6aXPpeJkh[XO|YYm= M{\lbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHU6OzdiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7LDDJR|UxKD1iMUmg{txONg>? NUXreXFPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yOlQ2ODNpPkK2NlY1PTB|PD;hQi=>
HCT116 MmjWRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MXG3NkBpenN? MnO5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG5MlY3KM7:TT6= NXX4[5NIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2PFQ4ODhpPkK5Olg1PzB6PD;hQi=>
GIST48 NX;CT2pKSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MljjPVYhcHK| MmHlRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDpcYF1cW6rYj3y[ZNqe3SjboSgbJVu[W5iR1nTWFQ5KGOnbHzzJIhiemKxcnnu[{BkNUuLVDDWOVYxTC:GOEKwRUBld3WkbHWgcZV1[W62IHHmeIVzKDl4IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSBzOT64JO69VS5? M2PsS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7N{K0OlU{Lz5{OUeyOFY2OzxxYU6=
A549 NX\RbFRVS3m2b4TvfIlkcXS7IHHzd4F6 NH;D[2g4OiCqcoO= NILZTpdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEG5Mlk2OjZizszNMi=> M1PsZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
CAL27 MV;DfZRwfG:6aXPpeJkh[XO|YYm= NF3wTlk4OiCqcoO= NH3PPVNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBESUx{NzDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCxPU46PTJ4IN88UU4> M3jITFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
Hec1A NUXObXE1S3m2b4TvfIlkcXS7IHHzd4F6 MYq3NkBpenN? MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[YMySSClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSBzOT65OVI3KM7:TT6= NVrjcJZYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
32D NWLocZNoS3m2b4TvfIlkcXS7IHHzd4F6 M37RbWN6fG:2b4jpZ{Bi[3Srdnn0fUBi\2GrboP0JI1wfXOnIEOySEBD[3JvYXLsJI5m\2G2aY\lJINmdGy|LDDJR|UxKD1iMkCg{txONg>? M2m3SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
GIST48B MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1npPFczKGi{cx?= MoTpS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gS2lUXDR6QjDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwJF0hOjBizszNMi=> NGfKZZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e3N|E2Oyd-MkO3O|MyPTN:L3G+
BV173 MnvBRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NGPycm0zPCCqcoO= NXnYRopkUW5idnn0do8h[W62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCWlE4OyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjBizszNMi=> NGXGUpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[4NVk5Pid-MkS2PFE6QDZ:L3G+
BAF3 NXmyW29ZTnWwY4Tpc44h[XO|YYm= NIHMNFI4OiCqcoO= Ml7ETY5pcWKrdHnvckBw\iCDQlygWFMyPUlibYX0ZY51KGmwIH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCyNE4xOyEQvF2u M{PlPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUe0N|M5Lz5{OEm3OFM{QDxxYU6=
293T Ml\DR5l1d3SxeHnjbZR6KGG|c3H5 MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjCyPVNVKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vNCCFQ{WwJF0hOjBwNUOg{txONg>? MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjh3MECwOEc,OjZ6NUCwNFQ9N2F-
CAL27 MVzDfZRwfG:6aXPpeJkh[XO|YYm= NXPzW4tHPzJiaILz NXTzelA4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0GOMkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGGuYX3hdk1jdHWnIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gNlIh|ryPLh?= NHHleHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
H460 MknER5l1d3SxeHnjbZR6KGG|c3H5 NXnLcop2PzJiaILz MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIOFYxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDJ2IN88UU4> NUj3XGVYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
PC3 M37ObWN6fG:2b4jpZ4l1gSCjc4PhfS=> NFfh[YM4OiCqcoO= NFHhW4xEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMkSg{txONg>? MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl|MEG5NFI9N2F-
HCT15 NUnSOoxiS3m2b4TvfIlkcXS7IHHzd4F6 M4C5PVczKGi{cx?= MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyPSClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB{NTFOwG0v M3fJb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
THP1 NWnHOZlPS3m2b4TvfIlkcXS7IHHzd4F6 MXrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDUTHAyKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSxiSVO1NEA:KDJ3IN88UU4> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ4NEWwN{c,OjZ{NkS1NFM9N2F-
HeLa M{nsSWN6fG:2b4jpZ4l1gSCjc4PhfS=> NEn6OoU4OiCqcoO= NHjIZZREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEK1MlEyQDlizszNMi=> NHj2WGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
H460 M2\WZmN6fG:2b4jpZ4l1gSCjc4PhfS=> NVT3NHBNPzJiaILz M2LHRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGg1PjBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMkWuNVE5QSEQvF2u NFv4UWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
HCT15 NXm3OItRS3m2b4TvfIlkcXS7IHHzd4F6 NYPBb|FtPzJiaILz NHrLZ3hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzNTDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCyOU4yOTh7IN88UU4> M3jYblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
PC3 M4racWN6fG:2b4jpZ4l1gSCjc4PhfS=> MXe3NkBpenN? NH7TOmpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMkWuNVE5QSEQvF2u MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl|MEG5NFI9N2F-
Saos2 MkfZR5l1d3SxeHnjbZR6KGG|c3H5 MV23NkBpenN? NYfrOlhFS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW2Gxc{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGGuYX3hdk1jdHWnIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gNlUvOTF6OTFOwG0v NEC0bHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
HEK293 M4q2SGZ2dmO2aX;uJIF{e2G7 NWq4boNIOyCvaX7z MnnXTY5pcWKrdHnvckBw\iCqdX3hckBQS1R|LX3l[IlifGWmIFHTVEshfXC2YXvlJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZYZ1\XJiMzDtbY5{KGK7IH\seY9z\XOlZX7j[UBie3OjeTygTWM2OCB;IEK1MlUh|ryPLh?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ2MUCyPUc,OjN{NEGwNlk9N2F-
Saos2 Ml\sR5l1d3SxeHnjbZR6KGG|c3H5 NHjCTmc4OiCqcoO= MoDNR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV4FwezJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMk[g{txONg>? NW\0ZVBORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
MCF7 Mo\kR5l1d3SxeHnjbZR6KGG|c3H5 M2DFTlczKGi{cx?= M134OWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iM{Cg{txONg>? Ml;GQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
A431 MVrDfZRwfG:6aXPpeJkh[XO|YYm= MlO1O|IhcHK| MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDNzIN88UU4> M1nLelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
H69 M3\aNWN6fG:2b4jpZ4l1gSCjc4PhfS=> MX[3NkBpenN? MWrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIOlkh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHHsZY1iei2kbIXlJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOzFwNkKyPEDPxE1w NGfBOlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
MCF7 MnOzR5l1d3SxeHnjbZR6KGG|c3H5 NFXkPVk4OiCqcoO= M1rUPWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iM{GuOlIzQCEQvF2u MljOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
A431 NHP3SGxEgXSxdH;4bYNqfHliYYPzZZk> MVO3NkBpenN? NYPUbZBDS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTR|MTDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCzNU43OjJ6IN88UU4> NIn6Z3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
H69 M4rieGN6fG:2b4jpZ4l1gSCjc4PhfS=> NWLFeVE4PzJiaILz NUXmUnVrS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUDZ7IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEOyJO69VS5? MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl|MEG5NFI9N2F-
BESM NF\kRnNEgXSxdH;4bYNqfHliYYPzZZk> M3;hWFg5KGi{cx?= M2rXXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEKHU12gZ4VtdHNiYX\0[ZIhQDhiaILzJIJ6KEiWUzDhd5NigSxiRVO1NEA:KDN{IN88UU4> NF;Xe4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEW0O|gyQSd-MkC1OFc5OTl:L3G+
HCT116 MWLBcpRq[2GwY3XyJIF{e2G7 MmTwRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{whUUN3MDC9JFM1NjRizszNMi=> M3vQSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{GyOFM1Lz5{NkOxNlQ{PDxxYU6=
CCRF-CEM NXu3SHBOS3m2b4TvfIlkcXS7IHHzd4F6 NHzPZ|Q4OiCqcoO= MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDR3JHNUOHTTDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCzOkDPxE1w NV2wN|VURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
MDA-MB-231 MkHHR5l1d3SxeHnjbZR6KGG|c3H5 MWW3NkBpenN? NE\6PJhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDN5IN88UU4> NHPyeFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
CCRF-CEM/VCR1000 MUXDfZRwfG:6aXPpeJkh[XO|YYm= NFfzSJA4OiCqcoO= NVu0fYNbS3m2b4TvfIlkcXS7IHHnZYlve3RidnnuZ5Jqe3SrbnWtdoV{cXO2YX70JIh2dWGwIFPDVmYuS0WPL2\DVlExODBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iM{eg{txONg>? MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl|MEG5NFI9N2F-
WM266.4 NUfuTVZlS3m2b4TvfIlkcXS7IHHzd4F6 MmrjO|IhcHK| MWLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDXUVI3Pi52IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEO3JO69VS5? NWrJbog1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
U87MG MnvsR5l1d3SxeHnjbZR6KGG|c3H5 M4TSRVczKGi{cx?= NHvSbmpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWQDePRzDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCzPEDPxE1w M1mwR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
SKBR3 MlTvR5l1d3SxeHnjbZR6KGG|c3H5 NXXoZZFZPzJiaILz M1HteWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMSlJ|IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEO5JO69VS5? MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl|MEG5NFI9N2F-
MDA-MB-231 MXrDfZRwfG:6aXPpeJkh[XO|YYm= MojNO|IhcHK| NIXOXZZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDN7LkixNFch|ryPLh?= M4fST|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
SKBR3 NUL4SWpZS3m2b4TvfIlkcXS7IHHzd4F6 NF;LfGs4OiCqcoO= M3v5[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMSlJ|IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEO5MlgyODdizszNMi=> NFjLNJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
AsPC1 MWrDfZRwfG:6aXPpeJkh[XO|YYm= NIDqR3k4OiCqcoO= M3XiV2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGF{WENzIHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEO5MlgyODdizszNMi=> NXXIfoE3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
CCRF-CEM/VCR1000 NInFOWtEgXSxdH;4bYNqfHliYYPzZZk> NWLnfFJKPzJiaILz M2Dob2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KH[rbnPybZN1cW6nLYLld4l{fGGwdDDoeY1idiCFQ2LGMWNGVS:YQ2KxNFAxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDN7LkixNFch|ryPLh?= M4DhZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
CCRF-CEM MYHDfZRwfG:6aXPpeJkh[XO|YYm= MW[3NkBpenN? NWX4OpZlS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0OURj3DSW0h[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHHsZY1iei2kbIXlJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOzlwOEGwO{DPxE1w MoC5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
U87MG NFWxNYxEgXSxdH;4bYNqfHliYYPzZZk> NYjmbmt5PzJiaILz MlriR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVg4VUdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iM{muPFExPyEQvF2u MnXKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
WM266.4 NXTx[FBXS3m2b4TvfIlkcXS7IHHzd4F6 NH3FfGU4OiCqcoO= NWnUfFlRS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hX01{Nk[uOEBk\WyuczDh[pRmeiB5MjDodpMh[nliYXzhcYFzNWKudXWgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA{QS56MUC3JO69VS5? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl|MEG5NFI9N2F-
AsPC1 M3XPfGN6fG:2b4jpZ4l1gSCjc4PhfS=> NUDKWZN3PzJiaILz MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBd3BEOSClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB2NDFOwG0v M{fodFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
CCRF-CEM M4O1PWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NITMeJIzPCCqcoO= MnzBTY4hfmm2cn:gZY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCFQ2LGMWNGVSClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDVizszNMi=> NFzQNWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[4NVk5Pid-MkS2PFE6QDZ:L3G+
A2780 M2HXRWN6fG:2b4jpZ4l1gSCjc4PhfS=> M{K4XlczKGi{cx?= M4jjT2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGEzPzhyIHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IES4JO69VS5? Mlj2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
Vero MlLBRY51cX[rcnHsJIF{e2G7 MXqzJIRigXN? MXHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDE[Y5ofWVidnnyeZMhcW6oZXP0[YQhcW5iYX\ybYNidiCpcnXlckBud26tZYmgWoVzdyClZXzsd{Bi\G2rbnnzeIVz\WRiYnXmc5JmKH[rcnHsJINp[WyuZX7n[UBi\nSncjCzJIRigXNiYomgeolz[WxicHzhdZVmKGG|c3H5 M2jpTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{[wOlc3Lz5zN{O2NFY4PjxxYU6=
Ba/F3 MUTGeY5kfGmxbjDhd5NigQ>? M4\NfVEhfU1? NYXJU3JZOjRiaILz M2TiUGlvcGmkaYTpc44hd2ZiMUStN{0{e2mpbXGgbY4hcHWvYX6gRoEwTjNiY3XscJMh\XiycnXzd4lv\yC5aXzkJJR6eGViQnPyMWFjdCClb37zeJJ2[3RiYYPz[ZN{\WRiYYOgdoVt\WG|ZTDv[kBnfWyuLXzlcod1cCClLVHicEBnem:vIHP5eI9xdGG|bXnjJINwdXCuZYige4l1cCBzND2zMVN{cWevYTDheEAyKHWPIHHmeIVzKDJ2IHjyd{BjgSCrbX31co9xemWlaYDpeIF1cW:wL3ntcZVvd2Kub4SgeIVkcG6rcYXl MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4MkW3Okc,OjF7NkK1O|Y9N2F-
Ba/F3 NWXRO3RCTnWwY4Tpc44h[XO|YYm= MVGxJJVO Mo[0NlQhcHK| MnzQTY5pcWKrdHnvckBw\iBzND2zMVN{cWevYTDpckBpfW2jbjDCZU9HOyClZXzsd{BmgHC{ZYPzbY5oKHerbHSgeJlx\SCEY4KtRYJtKGOxboP0dpVkfCCjc4Pld5Nm\CCjczDueYNt\WG{IHntdI9zfCCxZjDmeYxtNWynbnf0bEBkNUGkbDDheEAyKHWPIHHmeIVzKDJ2IHjyd{BjgSCrbX31co9xemWlaYDpeIF1cW:wL3ntcZVvd2Kub4SgeIVkcG6rcYXl M{iydlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[yOVc3Lz5{MUm2NlU4PjxxYU6=
Neuro2a Mnz4SpVv[3Srb36gZZN{[Xl? NI\wW|cyKHWP NFflR4pKdmirYnn0bY9vKG:oIFTSNlQhcW5iRHjjdlcu\GWoaXPp[Y51KG2xdYPlJG5mfXKxMnGgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hPy2GSFOgcIV3\Wy|IHH0JFEhfU1iYomgUGMuVVNxR1OtUXMh[W6jbInzbZM> MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OU[1O{c,OjZ5OEm2OVc9N2F-
K562 MUDGeY5kfGmxbjDhd5NigQ>? NIXFeIIyODBidV2= M3vrWlghcHK| M4mzTWlvcGmkaYTpc44hd2ZiQlPSMWFDVCC|aXfuZYxqdmdicHH0bJdigSCrbjDoeY1idiCNNU[yJINmdGy|IHHzd4V{e2WmIHHzJJN2eHC{ZYPzbY9vKG:oIGPURXQ2KHCqb4PwbI9zgWyjdHnvckBifCBzMECgeW0h[W[2ZYKgPEBpenNiaX6gdJJme2WwY3Wgc4YhVWWEUzDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN? Mm[4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4Nk[2N|UoRjJ5Nk[2OlM2RC:jPh?=
K562 NWDGepFOTnWwY4Tpc44h[XO|YYm= NH7jUZEyODBidV2= MkG2PEBpenN? NHvJRlVKdmirYnn0bY9vKG:oIFLDVk1CSkxiaX6gd4lodmGuaX7nJJBifGi5YYmgbJVu[W5iS{W2NkBk\WyuczDhd5Nme3OnZDDhd{B{fXCycnXzd4lwdiCxZjDDdotNKHCqb4PwbI9zgWyjdHnvckBifCBzMECgeW0h[W[2ZYKgPEBpenNiaX6gdJJme2WwY3Wgc4YhVWWEUzDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN? M1TtSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Nk[2OlM2Lz5{N{[2OlY{PTxxYU6=
K562 M3\wUGZ2dmO2aX;uJIF{e2G7 MX:xNFAhfU1? MoG2PEBpenN? MknjTY5pcWKrdHnvckBw\iCEQ2KtRWJNKHCqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBMPTZ{IHPlcIx{KGG2IEGwNEB2VSCjZoTldkA5KGi{czDpckBxemW|ZX7j[UBw\iCPZVLTJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= NXrPUlZ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2OlY3OzVpPkK3OlY3PjN3PD;hQi=>
K562 MoLMSpVv[3Srb36gZZN{[Xl? MXyxNEB2VQ>? MXixJIhz MnjHTY5pcWKrdHnvckBw\iC2eYLvd4lv\SCyaH;zdIhwenmuYYTpc44hd2ZicILveIVqdiC5aYToJI1wdGWldXzhdkB4\WmpaISgZoV1f2WnbjC0NEBidmRiNkCgb2RiKGmwIHj1cYFvKEt3NkKgZ4VtdHNiYYSgNVAhfU1iYX\0[ZIhOSCqcjDifUBqdW23bn;icI91KGGwYXz5d4l{ NHnLTlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[4NVk5Pid-MkS2PFE6QDZ:L3G+
K562 M{Xm[GZ2dmO2aX;uJIF{e2G7 MmfwNVAhfU1? M2j3dFEhcHJ? MYPJcohq[mm2aX;uJI9nKEKlcj;BZowhc2mwYYPlJJR6em:|aX7lJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDLOVYzKGOnbHzzJIF1KDFyIIXNJIFnfGW{IEGgbJIh[nliaX3teY5w[myxdDDhcoFtgXOrcx?= NHjmWoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[4NVk5Pid-MkS2PFE6QDZ:L3G+
K562 MXzGeY5kfGmxbjDhd5NigQ>? NEn5cVYyOCC3TR?= NIT6cVUyKGi{ M{P1NmlvcGmkaYTpc44hd2ZiQXLsJItqdmG|ZTD0fZJwe2mwZTDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iS{W2NkBk\WyuczDheEAyOCC3TTDh[pRmeiBzIHjyJIJ6KGmvbYXuc4Jtd3RiYX7hcJl{cXN? NVrudpdQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2PFE6QDZpPkK0OlgyQTh4PD;hQi=>
DAOY MmjtdWhVWyCjc4PhfS=> NFHvUHJyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBFSU:\IHPlcIx{ NEjuNWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
NCI-H1703 MlXhSpVv[3Srb36gZZN{[Xl? M3vQUFEhfU1? MXeyJIhzew>? NYXpXpltUW6qaXLpeIlwdiCxZjDQSGdHNWmwZIXj[YQhWESJRmLhcJBp[SCjdYTvdIhwe3Cqb4L5cIF1cW:wIHH0JHk4PTRicnXzbYR2\SCrbjDoeY1idiCQQ1mtTFE4ODNiY3XscJMh[XRiMTD1UUBi\nSncjCyJIhzeyCrbjDwdoV{\W6lZTDv[kBRTEeILVHBJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= NX3rNFFMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFQyPDlpPkK5OVQ1OTR7PD;hQi=>
NCI-H1703 NYfLbnBSTnWwY4Tpc44h[XO|YYm= NV\0XYdoOSC3TR?= MnK2NkBpenN? NYnkfII4UW6qaXLpeIlwdiCxZjDQSGdHNWmwZIXj[YQhWESJRmLhcJBp[SCjdYTvdIhwe3Cqb4L5cIF1cW:wIHH0JHkyODF6IILld4llfWViaX6gbJVu[W5iTlPJMWgyPzB|IHPlcIx{KGG2IEGgeW0h[W[2ZYKgNkBpenNiaX6gdJJme2WwY3Wgc4YhWESJRj3BRUBjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= MkHFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NESxOFkoRjJ7NUS0NVQ6RC:jPh?=
NCI-H1703 M{PtPGZ2dmO2aX;uJIF{e2G7 MU[xJJVO NVy3c3c4OiCqcoO= MlrFTY5pcWKrdHnvckBw\iCSRFfGMYlv\HWlZXSgVGRITlKjbIDoZUBifXSxcHjvd5Bpd3K7bHH0bY9vKGG2IGm4OFkhemW|aXT1[UBqdiCqdX3hckBPS0lvSEG3NFMh[2WubIOgZZQhOSC3TTDh[pRmeiB{IHjyd{BqdiCycnXz[Y5k\SCxZjDQSGdHNUGDIHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? M13MWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUS0NVQ6Lz5{OUW0OFE1QTxxYU6=
EOL-1 MnmySpVv[3Srb36gZZN{[Xl? MlTvNUB2VQ>? NWLtTodVOiCqcoO= M4\sOWlvcGmkaYTpc44hd2ZiUFTHSnJidHCqYTDpckBpfW2jbjDFU2wuOSClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDTWGFVPSCyaH;zdIhwenmuYYTpc44h[XRiWU[5OEBz\XOrZIXlJIF1KDFidV2gZYZ1\XJiMjDodpMhcW5icILld4Vv[2Vib3[gVGRITi2DQTDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN? NWLLNW9tRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFQyPDlpPkK5OVQ1OTR7PD;hQi=>
EOL-1 MYjGeY5kfGmxbjDhd5NigQ>? MmKzNUB2VQ>? NHnrbFgzKGi{cx?= Ml3KTY5pcWKrdHnvckBw\iCSRFfGVoFteGijIHnuJIh2dWGwIFXPUE0yKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIFXST{BxcG:|cHjvdplt[XSrb36gZZQhXDJyMj;ZNlA1KHKnc3nkeYV{KGG2IEGgeW0h[W[2ZYKgNkBpenNiaX6gdJJme2WwY3Wgc4YhWESJRj3BRUBjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= MljaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NESxOFkoRjJ7NUS0NVQ6RC:jPh?=
K562 NFS2d3NHfW6ldHnvckBie3OjeR?= NWXD[JFqOSC3TR?= Ml\tTY5pcWKrdHnvckBw\iCEQ2KtRWJNKGmwIHntZZRqdmmkLYPlcpNqfGm4ZTDoeY1idiCNNU[yJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKEO{S1ygdIhwe3Cqb4L5cIF1cW:wIHH0JFEhfU1iYomgbY1ufW6xIHLsc5Qh[W6jbInzbZM> MknLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{NkG0OlgoRjNyMk[xOFY5RC:jPh?=
BA/F3 M4nneWFvfGm2dX3vdkBie3OjeR?= MYS1NEBu\y:tZx?= MnrxNVQh\GG7cx?= MUnBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCEQT;GN{Bk\WyuczDlfJBz\XO|aX7nJJdqdGRidInw[UBDS1JvQVLMJIFtdG:pcnHmeIVlKGmwIGPDTWQhdW:3c3WgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD0eY1weiCpcn;3eIgh[XRiNUCgcYcwc2duIIDvJJFlKG[xcjCxOEBl[Xm| MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN|MEG3NFM9N2F-
Ba/F3 M3:3bmZ2dmO2aX;uJIF{e2G7 NGDzWYQyKGi{ NFjlXIZKdmirYnn0bY9vKG:oIFLjdk1C[mxiVEOxOWkhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSmFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKHCqb4PwbI9zgWyjdHXkJHNVSVR3IHzleoVtKGGodHXyJFEhcHJiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ NGr6dWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNFgxPid-MkO2NFA5ODZ:L3G+
Ba/F3 M3nWSGZ2dmO2aX;uJIF{e2G7 MVmxJIhz M3fyWGlvcGmkaYTpc44hd2ZiQnPyMWFjdCCWM{G1TUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBD[S:IMzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4YheGixc4Doc5J6dGG2ZXSgR5JsVCCuZY\lcEBi\nSncjCxJIhzKGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> M3n2VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkCwPFA3Lz5{M{[wNFgxPjxxYU6=
Ba/F3 M3TUfmZ2dmO2aX;uJIF{e2G7 NIG1epQyKGi{ MWLJcohq[mm2aX;uJI9nKEKlcj3BZowhXDNzNVmgcZV1[W62IDj1cotvd3ewIH;ybYdqdilicHjvd5Bpd3K7bHH0bY9vKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLhM2Y{KGOnbHzzJIFnfGW{IEGgbJIh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz Mlf1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MEC4NFYoRjJ|NkCwPFA3RC:jPh?=
K562 MlLNSpVv[3Srb36gZZN{[Xl? M2nUXVYhcHK| NIfKbIVKdmirYnn0bY9vKG:oIFLDVk1CSkxvbXXkbYF1\WRiU2TBWFUheGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgOkBpenNiYomgdIhwe3Cqbz3mcI94KGO7dH;t[ZRzgQ>? NUHYe4NSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOFg2QDRpPkKyNVQ5PTh2PD;hQi=>
K562 Mny5SpVv[3Srb36gZZN{[Xl? MVK0NEB2VQ>? M1fSPFYhcHK| MVHJcohq[mm2aX;uJI9nKEKFUj3BRmwudWWmaXH0[YQhTVKNMTDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iS{W2NkBk\WyuczDheEA1OCC3TTDh[pRmeiB4IHjyd{BjgSCyaH;zdIhwNW[ub4egZ5l1d22ndIL5 Mo\oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNEi1PFQoRjJ{MUS4OVg1RC:jPh?=
K562 NFXyXItHfW6ldHnvckBie3OjeR?= NWDKemplPDBidV2= NH\vTo83KGi{cx?= MXXJcohq[mm2aX;uJI9nKEKFUj3BRmwudWWmaXH0[YQhTVKNMjDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iS{W2NkBk\WyuczDheEA1OCC3TTDh[pRmeiB4IHjyd{BjgSCyaH;zdIhwNW[ub4egZ5l1d22ndIL5 NV3Ub5hnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOFg2QDRpPkKyNVQ5PTh2PD;hQi=>
GISTT1 M3\LcmZ2dmO2aX;uJIF{e2G7 MUKxJJVO M1vVXVIhcHK| NELvc|JKdmirYnn0bY9vKG:oIHOtT2lVKGG3dH;wbI9{eGixconsZZRqd25iYYSgXVcyQSCrbjDoeY1idiCJSWPUWFEh[2WubIOgZZQhOSC3TTDt[YF{fXKnZDDh[pRmeiB{IHjyd{BjgSCrbX31co9jdG:2dHnu[y=> M1raNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GISTT1 NIXt[3lHfW6ldHnvckBie3OjeR?= MUixJJVO NHG3TJkzKGi{cx?= NX3Mb|g4UW6qaXLpeIlwdiCxZjDjMWtKXCCjdYTvdIhwe3Cqb4L5cIF1cW:wIHH0JHk5OjNiaX6gbJVu[W5iR1nTWHQyKGOnbHzzJIF1KDFidV2gcYVie3W{ZXSgZYZ1\XJiMjDodpMh[nliaX3teY5w[myxdITpcoc> NFHyb4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
GISTT1 MYTGeY5kfGmxbjDhd5NigQ>? MmD4NUB2VQ>? NFPFbVQzKGi{cx?= NUjvOpRvUW6qaXLpeIlwdiCxZjDjMWtKXCCjdYTvdIhwe3Cqb4L5cIF1cW:wIHH0JHk4ODNiaX6gbJVu[W5iR1nTWHQyKGOnbHzzJIF1KDFidV2gcYVie3W{ZXSgZYZ1\XJiMjDodpMh[nliaX3teY5w[myxdITpcoc> MoDyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
GIST882 MX\GeY5kfGmxbjDhd5NigQ>? NVPlSndYOSC3TR?= M2PMelIhcHK| M2TjTWlvcGmkaYTpc44hd2ZiYz3LTXQh[XW2b4Doc5NxcG:{eXzheIlwdiCjdDDZPFI{KGmwIHj1cYFvKEeLU2S4PFIh[2WubIOgZZQhOSC3TTDt[YF{fXKnZDDh[pRmeiB{IHjyd{BjgSCrbX31co9jdG:2dHnu[y=> M17KN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GIST882 MmD3SpVv[3Srb36gZZN{[Xl? NHnNe3oyKHWP Ml\WNkBpenN? M4flcmlvcGmkaYTpc44hd2ZiYz3LTXQh[XW2b4Doc5NxcG:{eXzheIlwdiCjdDDZO|A{KGmwIHj1cYFvKEeLU2S4PFIh[2WubIOgZZQhOSC3TTDt[YF{fXKnZDDh[pRmeiB{IHjyd{BjgSCrbX31co9jdG:2dHnu[y=> M4L3SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GIST882 Mn\HSpVv[3Srb36gZZN{[Xl? MlmzNUB2VQ>? M{HYbVIhcHK| NGG4VW5KdmirYnn0bY9vKG:oIHOtT2lVKGG3dH;wbI9{eGixconsZZRqd25iYYSgXVcyQSCrbjDoeY1idiCJSWPUPFgzKGOnbHzzJIF1KDFidV2gcYVie3W{ZXSgZYZ1\XJiMjDodpMh[nliaX3teY5w[myxdITpcoc> M2rUSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GISTT1 MojlSpVv[3Srb36gZZN{[Xl? NEPp[oIyKHWP MWeyJIhzew>? MlS3TY5pcWKrdHnvckBw\iClLVvJWEBu\WSrYYTl[EB{cWewYXzpcocheGG2aIfhfZMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJGFMXCCyaH;zdIhwenmuYYTpc44h[XRiU{S3N{BqdiCqdX3hckBIUVOWVEGgZ4VtdHNiYYSgNUB2VSCvZXHzeZJm\CCjZoTldkAzKGi{czDifUBqdW23bn;icI91fGmwZx?= Mo\pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
GISTT1 MXfGeY5kfGmxbjDhd5NigQ>? MWCxJJVO MmDYNkBpenN? MUnJcohq[mm2aX;uJI9nKGNvS1nUJI1m\GmjdHXkJJNq\26jbHnu[{Bx[XSqd3H5d{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gV5RifDNxNTDwbI9{eGixconsZZRqd25iYYSgXVcxPS:\Nkm0JIlvKGi3bXHuJGdKW1SWMTDj[YxteyCjdDCxJJVOKG2nYYP1doVlKGGodHXyJFIhcHK|IHL5JIludXWwb3Lsc5R1cW6p NVLQVJRCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GISTT1 MorVSpVv[3Srb36gZZN{[Xl? M2HvXVEhfU1? Mn3TNkBpenN? M1;ydWlvcGmkaYTpc44hd2ZiYz3LTXQhdWWmaXH0[YQhe2mpbnHsbY5oKHCjdHj3ZZl{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBGWktzL{KgdIhwe3Cqb4L5cIF1cW:wIHH0JHQzODJxWUKwOEBqdiCqdX3hckBIUVOWVEGgZ4VtdHNiYYSgNUB2VSCvZXHzeZJm\CCjZoTldkAzKGi{czDifUBqdW23bn;icI91fGmwZx?= NUfiPYxURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GISTT1 M3\nSmZ2dmO2aX;uJIF{e2G7 NIHQOnIyKHWP MV:yJIhzew>? M4K2dWlvcGmkaYTpc44hd2ZiYz3LTXQhdWWmaXH0[YQhe2mpbnHsbY5oKHCjdHj3ZZl{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBUPiCyaH;zdIhwenmuYYTpc44h[XRiU{KzOU8zOzZiaX6gbJVu[W5iR1nTWHQyKGOnbHzzJIF1KDFidV2gcYVie3W{ZXSgZYZ1\XJiMjDodpMh[nliaX3teY5w[myxdITpcoc> M3;lNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GIST882 NXHLSYdMTnWwY4Tpc44h[XO|YYm= MlS2NUB2VQ>? NFjJTFczKGi{cx?= MmXwTY5pcWKrdHnvckBw\iClLVvJWEBu\WSrYYTl[EB{cWewYXzpcocheGG2aIfhfZMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJHM3KHCqb4PwbI9zgWyjdHnvckBifCCVMkO1M|I{PiCrbjDoeY1idiCJSWPUPFgzKGOnbHzzJIF1KDFidV2gcYVie3W{ZXSgZYZ1\XJiMjDodpMh[nliaX3teY5w[myxdITpcoc> MmXOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
GIST882 MlfaR4VtdCCleXPs[UBie3OjeR?= NUXBcXB{OSC3TR?= MmDKOFghcHK| MXrD[YxtKGO7Y3zlJIFzemW|dDDpckBpfW2jbjDHTXNVQDh{IHPlcIx{KGG|c3Xzd4VlKGG|IHHjZ5VufWyjdHnvckBifCCJMD;HNUBxcGG|ZTDheEAyKHWPIHHmeIVzKDR6IHjyd{BjgSCycn;wbYRqfW1iaX;kbYRmN1KQYYPlJJN1[WmwaX7nJIJie2WmIH\sc5ch[3m2b33leJJ6 MoSwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
K562 M{C5SGFxd3C2b4Ppd{Bie3OjeR?= MoGxNUB2VQ>? M{\kTGlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iS{W2NkBk\WyuczDhd5Nme3OnZDDhd{BkdGWjdnHn[UBw\iCSQWLQJIF1KDFidV2gZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| NWn4fYxQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
K562 MmD5RZBweHSxc3nzJIF{e2G7 NHqx[JoyKHWP NXnheWdpUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDLOVYzKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHPs[YF3\WRiY3HzdIF{\S1|IHzleoVtKGG2IEGgeW0h[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz MlvOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
K562 NWHDO4g{S2WubDDjfYNt\SCjc4PhfS=> NUXG[YdZOSC3TR?= NH7QT5IzPCCqcoO= NIXpcIFE\WyuIHP5Z4xmKGG{cnXzeEBqdiCqdX3hckBMPTZ{IHPlcIx{KGG|c3Xzd4VlKGG|IHHjZ5VufWyjdHnvckBifCCJMD;HNUBxcGG|ZTDheEAyKHWPIHHmeIVzKDJ2IHjyd{BjgSCycn;wbYRqfW1iaX;kbYRmN1KQYYPlJJN1[WmwaX7nJIJie2WmIH\sc5ch[3m2b33leJJ6 NX\Eb5NqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GISTT1 M3HvVWZ2dmO2aX;uJIF{e2G7 MmDHNUB2VQ>? M{Pv[|IhcHK| M3qwRWlvcGmkaYTpc44hd2ZiYz3LTXQhdWWmaXH0[YQhe2mpbnHsbY5oKHCjdHj3ZZl{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBUPkticHjvd5Bpd3K7bHH0bY9vKGG2IGSzPFkhcW5iaIXtZY4hT0mVVGSxJINmdGy|IHH0JFEhfU1ibXXhd5Vz\WRiYX\0[ZIhOiCqcoOgZpkhcW2vdX7vZoxwfHSrbne= M4XTZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
KU812 M4XLUmFxd3C2b4Ppd{Bie3OjeR?= MVOxJJVO MU\JcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEuXOEGyJINmdGy|IHHzd4V{e2WmIHHzJINt\WG4YXflJI9nKFCDUmCgZZQhOSC3TTDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN? MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GIST882 MYjGeY5kfGmxbjDhd5NigQ>? MU[xJJVO MVyyJIhzew>? NVu3fmloUW6qaXLpeIlwdiCxZjDjMWtKXCCvZXTpZZRm\CC|aXfuZYxqdmdicHH0bJdigXNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKFO2YYSzM|UheGixc4Doc5J6dGG2aX;uJIF1KFl5MEWvXVY6PCCrbjDoeY1idiCJSWPUPFgzKGOnbHzzJIF1KDFidV2gcYVie3W{ZXSgZYZ1\XJiMjDodpMh[nliaX3teY5w[myxdITpcoc> Mn;kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
KU812 MYPBdI9xfG:|aYOgZZN{[Xl? MXGxJJVO MlnpTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCNVUixNkBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiClbHXheoVlKGOjc4Dhd4UuOyCuZY\lcEBifCBzIIXNJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= NIjSeoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
GIST882 NIfQcYdHfW6ldHnvckBie3OjeR?= NV3LdZA4OSC3TR?= MV:yJIhzew>? NET6SmlKdmirYnn0bY9vKG:oIHOtT2lVKG2nZHnheIVlKHOrZ37hcIlv\yCyYYToe4F6eyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hTVKNMT:yJJBpd3OyaH;yfYxifGmxbjDheEBVOjB{L2myNFQhcW5iaIXtZY4hT0mVVEi4NkBk\WyuczDheEAyKHWPIH3lZZN2emWmIHHmeIVzKDJiaILzJIJ6KGmvbYXuc4Jtd3S2aX7n M{nBUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GIST882 NHL5NY1HfW6ldHnvckBie3OjeR?= NVzZ[XYyOSC3TR?= MUSyJIhzew>? NVrlSZJ7UW6qaXLpeIlwdiCxZjDjMWtKXCCvZXTpZZRm\CC|aXfuZYxqdmdicHH0bJdigXNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKFN4SzDwbI9{eGixconsZZRqd25iYYSgWFM5QSCrbjDoeY1idiCJSWPUPFgzKGOnbHzzJIF1KDFidV2gcYVie3W{ZXSgZYZ1\XJiMjDodpMh[nliaX3teY5w[myxdITpcoc> NFXHPIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
KU812 NIW4XlBE\WyuIHP5Z4xmKGG|c3H5 MnuwNUB2VQ>? MmDJNVIhcHK| M{fBT2NmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJGtWQDF{IHPlcIx{KGG|c3Xzd4VlKGG|IHHjZ5VufWyjdHnvckBifCCJMD;HNUBxcGG|ZTDheEAyKHWPIHHmeIVzKDF{IHjyd{BjgSCycn;wbYRqfW1iaX;kbYRmN1KQYYPlJJN1[WmwaX7nJIJie2WmIH\sc5ch[3m2b33leJJ6 MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
MEG01 NEXoe2dCeG:ydH;zbZMh[XO|YYm= MmrENUB2VQ>? Mn:2TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCPRVewNUBk\WyuczDhd5Nme3OnZDDhd{BkdGWjdnHn[UBw\iCSQWLQJIF1KDFidV2gZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GISTT1 NYj3bYJvSXCxcITvd4l{KGG|c3H5 M2\kR|EhfU1? NGTR[JdKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIFfJV3RVOSClZXzsd{Bie3Onc4Pl[EBieyClbHXheoFo\SCxZjDQRXJRKGG2IEGgeW0h[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz M3fSSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GIST882 MnzjRZBweHSxc3nzJIF{e2G7 NFPlNogyKHWP MYfJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEeLU2S4PFIh[2WubIOgZZN{\XO|ZXSgZZMh[2ynYY\h[4Uhd2ZiUFHSVEBifCBzIIXNJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GIST882 M3;5VWFxd3C2b4Ppd{Bie3OjeR?= MWqxJJVO M{\vcmlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iR1nTWFg5OiClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDjcIVifmWmIHPhd5Bie2VvMzDs[ZZmdCCjdDCxJJVOKGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> NHTwZnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
MEG01 NF3RVY5E\WyuIHP5Z4xmKGG|c3H5 M1jBR|EhfU1? M{TLZ|I1KGi{cx?= NYriS2xTS2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hVUWJMEGgZ4VtdHNiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKGG2IFewM2cyKHCqYYPlJIF1KDFidV2gZYZ1\XJiMkSgbJJ{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVxUl7hd4Uhe3SjaX7pcoch[mG|ZXSg[oxwfyCleYTvcYV1enl? NU\aPHJoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GISTT1 MWXD[YxtKGO7Y3zlJIF{e2G7 NE\VXmMyKHWP NWr0emJMOjRiaILz MkXqR4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gS2lUXFRzIHPlcIx{KGG|c3Xzd4VlKGG|IHHjZ5VufWyjdHnvckBifCCJMD;HNUBxcGG|ZTDheEAyKHWPIHHmeIVzKDJ2IHjyd{BjgSCycn;wbYRqfW1iaX;kbYRmN1KQYYPlJJN1[WmwaX7nJIJie2WmIH\sc5ch[3m2b33leJJ6 NHziUJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
MEG01 MmPoRZBweHSxc3nzJIF{e2G7 NUHxPJZ7OSC3TR?= M{LRV2lv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iTVXHNFEh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iY3zlZZZm\CClYYPwZZNmNTNibHX2[Ywh[XRiMTD1UUBjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= NHHqO409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
GISTT1 M{PnW2Fxd3C2b4Ppd{Bie3OjeR?= M{TjRlEhfU1? NX\kVm1mUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDHTXNVXDFiY3XscJMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZ4xm[X[nZDDjZZNx[XOnLUOgcIV3\WxiYYSgNUB2VSCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> NYHCb3c3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GIST882 M3;WcmZ2dmO2aX;uJIF{e2G7 NGK3S4wyKHWP Mn\QNkBpenN? MUHJcohq[mm2aX;uJI9nKGNvS1nUJI1m\GmjdHXkJJNq\26jbHnu[{Bx[XSqd3H5d{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gRWtVKHCqb4PwbI9zgWyjdHnvckBifCCVNEezJIlvKGi3bXHuJGdKW1R6OEKgZ4VtdHNiYYSgNUB2VSCvZXHzeZJm\CCjZoTldkAzKGi{czDifUBqdW23bn;icI91fGmwZx?= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
LAMA-84 NVTLeHd2T3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= NXLm[YRWUW6qaXLpeIlwdiCxZjDoeY1idiCOQV3BMVg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSByLkC3N|A1KM7:TT6= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
EM-2 MUjHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? MorMTY5pcWKrdHnvckBw\iCqdX3hckBGVS1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCwMlA5QDhizszNMi=> M{XOPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
MEG-01 M4WwVWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 MYTJcohq[mm2aX;uJI9nKGi3bXHuJG1GTy1yMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gNE4xQDl{MTFOwG0v MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
BV-173 NUfrb2oyT3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= NGW1fYVKdmirYnn0bY9vKG:oIHj1cYFvKEKYLUG3N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOC5zOEe0JO69VS5? NYO4bFJxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
K-562 Ml\VS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? MUXJcohq[mm2aX;uJI9nKGi3bXHuJGsuPTZ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCwMlIzPDN{IN88UU4> NESwT4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
CGTH-W-1 NFq3TYFIem:5dHigTY5pcWKrdHnvckBie3OjeR?= M1j0cWlvcGmkaYTpc44hd2ZiaIXtZY4hS0eWSD3XMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDBwM{izO|Qh|ryPLh?= NX\GUWxURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
ST486 Ml6zS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? M4T6[WlvcGmkaYTpc44hd2ZiaIXtZY4hW1R2OE[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFAvPjh3NDFOwG0v NHu3N4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
NCI-H1436 NVi4dIFGT3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= MYTJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUSzOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOC57N{iwNUDPxE1w MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
NOS-1 NX6x[lJWT3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= NHzLVZVKdmirYnn0bY9vKG:oIHj1cYFvKE6RUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAyNjZ3M{izJO69VS5? M2D1TVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
A498 NWLp[I5tT3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= MlK2TY5pcWKrdHnvckBw\iCqdX3hckBCPDl6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCyMlU4OjJ|IN88UU4> NFXrPWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
BE-13 NHPTdHJIem:5dHigTY5pcWKrdHnvckBie3OjeR?= MnvqTY5pcWKrdHnvckBw\iCqdX3hckBDTS1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gNk43OjFyNjFOwG0v MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
SUP-T1 NVmxd|lQT3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= M13aVmlvcGmkaYTpc44hd2ZiaIXtZY4hW1WSLWSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA{Njh{OUC3JO69VS5? Ml;yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
NCI-H1770 NUKxPHFUT3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= NGrCNY5KdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVc4OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iNT61O|I3OiEQvF2u Mlv6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
IMR-5 NUjlZphQT3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= M1;z[mlvcGmkaYTpc44hd2ZiaIXtZY4hUU2ULUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFYvOjJzNEeg{txONg>? NEO2W2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
LB2241-RCC M4XWXWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 M3fGTWlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ{MkSxMXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iOD6wO|M5PCEQvF2u M2XqSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
TGBC24TKB NYPXflkxT3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= MVjJcohq[mm2aX;uJI9nKGi3bXHuJHRISkN{NGTLRkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hQC5|NEC1NkDPxE1w M3jEeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
SCC-15 M2K2UWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 MVrJcohq[mm2aX;uJI9nKGi3bXHuJHNESy1zNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gNVAvPzd6ODFOwG0v NHnUTGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
BB49-HNC NFTiZ3VIem:5dHigTY5pcWKrdHnvckBie3OjeR?= NEHKXolKdmirYnn0bY9vKG:oIHj1cYFvKEKENEmtTG5EKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSBzND6zN|M2KM7:TT6= M4rM[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
ES7 NYHsS2tDT3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= MYHJcohq[mm2aX;uJI9nKGi3bXHuJGVUPyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMUSuO|M4QSEQvF2u NVW2UpJpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
LB2518-MEL M3PQVmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 M1K1d2lvcGmkaYTpc44hd2ZiaIXtZY4hVEJ{NUG4MW1GVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMU[uOlA6PCEQvF2u MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
NCI-H510A M{PCRWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 MnjuTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWxNGEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF5LkK0OFIh|ryPLh?= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
TE-441-T MVTHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? NXz3R4xxUW6qaXLpeIlwdiCxZjDoeY1idiCWRT20OFEuXCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMUeuNlg5PiEQvF2u M{K2bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
HH NH3jW3ZIem:5dHigTY5pcWKrdHnvckBie3OjeR?= M3fLU2lvcGmkaYTpc44hd2ZiaIXtZY4hUEhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEG3MlM6QTlizszNMi=> NX;1eXdERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
LC4-1 MXjHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? NHfFempKdmirYnn0bY9vKG:oIHj1cYFvKEyFND2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAyQC5yNkWyJO69VS5? MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
KARPAS-45 MULHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? NX3WVFQ{UW6qaXLpeIlwdiCxZjDoeY1idiCNQWLQRXMuPDViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEG4MlE5PDhizszNMi=> NFjsdGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
LB1047-RCC Mn7VS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? NWXwenFyUW6qaXLpeIlwdiCxZjDoeY1idiCOQkGwOFcuWkOFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCxPE41PDV{IN88UU4> NVixfm45RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
NKM-1 M2PIemdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 M1rTRWlvcGmkaYTpc44hd2ZiaIXtZY4hVkuPLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFE6NjN3NUKg{txONg>? MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
SCLC-21H NInyRm5Iem:5dHigTY5pcWKrdHnvckBie3OjeR?= MW\Jcohq[mm2aX;uJI9nKGi3bXHuJHNEVENvMkHIJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzOC5zMkS2JO69VS5? NV7Oe3N6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
RS4-11 MUDHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? NV2ye5RLUW6qaXLpeIlwdiCxZjDoeY1idiCUU{StNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDJyLkOzNFgh|ryPLh?= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
ALL-PO NFHzcWlIem:5dHigTY5pcWKrdHnvckBie3OjeR?= M4\PSmlvcGmkaYTpc44hd2ZiaIXtZY4hSUyOLWDPJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzOC56MUS5JO69VS5? NWrEc3dTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
GDM-1 M4nkV2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7 NVmzWFJnUW6qaXLpeIlwdiCxZjDoeY1idiCJRF2tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOjJwNUm0OUDPxE1w MnPGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
DMS-79 NHjBfGdIem:5dHigTY5pcWKrdHnvckBie3OjeR?= NY\4Xm5SUW6qaXLpeIlwdiCxZjDoeY1idiCGTWOtO|kh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDJ2LkS5N|Qh|ryPLh?= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
MPP-89 MlLRS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? NIHrNHRKdmirYnn0bY9vKG:oIHj1cYFvKE2SUD24PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOjVwNki3OEDPxE1w MoTSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
NB10 NF3YOZFIem:5dHigTY5pcWKrdHnvckBie3OjeR?= MoLSTY5pcWKrdHnvckBw\iCqdX3hckBPSjFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCyOk41PyEQvF2u MmLmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
LS-513 NITCVWZIem:5dHigTY5pcWKrdHnvckBie3OjeR?= Mn6xTY5pcWKrdHnvckBw\iCqdX3hckBNWy13MUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFI3Njh6NEeg{txONg>? NYrVT21yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
L-540 MULHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? MYfJcohq[mm2aX;uJI9nKGi3bXHuJGwuPTRyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCyOk46OTR|IN88UU4> M{fMcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
ES1 NWnSZlVjT3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= MlflTY5pcWKrdHnvckBw\iCqdX3hckBGWzFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEK3MlUzOSEQvF2u M3XlfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
NTERA-S-cl-D1 M4Xjd2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7 MX\Jcohq[mm2aX;uJI9nKGi3bXHuJG5VTVKDLWOtZ4wuTDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEOwMlUxQTNizszNMi=> M3rmbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
EW-1 M37qcWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 MXTJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEOyMlk1PTRizszNMi=> MnG4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
Calu-6 M2TPc2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7 NXnLWGhvUW6qaXLpeIlwdiCxZjDoeY1idiCFYXz1MVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDN|LkG4OVUh|ryPLh?= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
CTV-1 M1L0ZWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 NFzRXGtKdmirYnn0bY9vKG:oIHj1cYFvKEOWVj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA{Oy57N{i5JO69VS5? NG\Dcok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
YT MXzHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? Ml\zTY5pcWKrdHnvckBw\iCqdX3hckB[XCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iM{iuOVIxQSEQvF2u M33DflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
TE-6 NI[0UpBIem:5dHigTY5pcWKrdHnvckBie3OjeR?= NVzrZVBIUW6qaXLpeIlwdiCxZjDoeY1idiCWRT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1OS5{N{m3JO69VS5? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
HT-144 Mnu0S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? Mlr3TY5pcWKrdHnvckBw\iCqdX3hckBJXC1zNESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQyNjV2OE[g{txONg>? MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
EW-13 MorYS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? MVLJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTC0Nk4zPzlzIN88UU4> M4CxTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
KALS-1 MkHaS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? Mn75TY5pcWKrdHnvckBw\iCqdX3hckBMSUyVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ{NjF|Mkig{txONg>? MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
MOLT-16 NEjG[I5Iem:5dHigTY5pcWKrdHnvckBie3OjeR?= NYjBVYZrUW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVE3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB2NT6wO|UzKM7:TT6= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
D-336MG M1nkOGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 NUnpeG1ZUW6qaXLpeIlwdiCxZjDoeY1idiCGLUOzOm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB2NT65OVk6KM7:TT6= M4S2T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
TE-11 M4jVXmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 M{PrN2lvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ3NjZ3MzFOwG0v MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
EB2 NV7HS4hsT3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= NE\XTY5KdmirYnn0bY9vKG:oIHj1cYFvKEWEMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gOFYvPjl7IN88UU4> NFvUN3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
SK-N-DZ M{\kW2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7 Mo\jTY5pcWKrdHnvckBw\iCqdX3hckBUUy2QLVTaJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1QC5yOU[xJO69VS5? NF;mTIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
SW684 MoXTS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? MXjJcohq[mm2aX;uJI9nKGi3bXHuJHNYPjh2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTC0PE4zPjl3IN88UU4> MnS1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
EW-18 MVvHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? M{TB[2lvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ5NjR|OUWg{txONg>? M1zqUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ZAP70 / ZAP70 / p-LAT / LAT; 

PubMed: 18981115     


For the analysis of imatinib interference with early TCR signaling events, cells were activated for 5 min with anti-CD3 and anti-CD28 Abs and blots were probed with anti-phospho ZAP70, anti-ZAP70, anti-phospho LAT or anti-LAT antibodies. Untreated, non-ac䲧疝Ỵ疞㧀疜膉痘瘿�෋ᾰƌ෋à

p-STAT3 / STAT3 / p-STAT5 / STAT5; 

PubMed: 18981115     


For phospho-STAT3 and Phospho-STAT5 detection, cells were then activated for 6 hrs with anti-CD3 and anti-CD28 Ab. Equivalent amounts of protein from cell lysates were separated by SDS-PAGE and western blot analysis was then performed using anti-phospho S䲧疝Ỵ疞㧀疜膉痘瘿뙠ෆᾰƌෆĀ㺣痖帉痖

18981115
Immunofluorescence
Cortactin / F-actin; 

PubMed: 20937825     


NIH3T3-SrcY527F cells were treated with DMSO or with 10 μm STI571 for 16 h, fixed and co-stained for cortactin (red, left panels) and F-actin (green, middle panels). Merged fields (right panels) demonstrate co-localization between cortactin and F-actin at䲧疝Ỵ疞㧀疜

RelB; 

PubMed: 20371728     


Nuclear proteins were extracted from the untreated and treated cells and nuclear levels of RelA and RelB were confirmed by immunocytochemistry 

20937825 20371728
Growth inhibition assay
Cell viability ; 

PubMed: 28435223     


(C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. 䲧疝Ỵ疞㧀疜膉痘瘿�෋ᾰƌ෋à㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺

28435223
体内研究 Imatinib抑制从新鲜的人小细胞肺癌外科样品来源的SCLC6,SCLC61和SCLC108异种移植肿瘤,抑制率分别是80%,40%和78%,且对SCLC74生长长无显著抑制。[5] 在高脂肪喂养的ApoE(-/-)小鼠中,通过管饲法给药10 mg/kg,20 mg/kg和40 mg/kg Imatinib,和对照组相比高脂诱导的脂质染色区域减少了30%,27%和35%,并且颈动脉脂质积聚得到抑制。[6]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
- 合并

PDGF受体激酶活性 :

PDGF受体是由BALB / c3T3细胞提取物免疫共沉淀所得,通过兔抗PDGF受体冰上处理2小时所得。蛋白A-琼脂糖珠被用于收集抗原-抗体复合物。免疫沉淀物用TNET(50 mM Tris,pH 7.5,140 mM氯化钠,5mM的EDTA,1%的Triton X-100)洗涤两次,用TNE(50 mM Tris,pH 7.5,140 mM EDTA)洗涤一次,并用激酶缓冲液(20 mM的Tris,pH 7.5, 10 mM氯化镁)洗涤一次。用PDGF(50 ng/mL)在4℃下刺激10分钟后,不同浓度的药物加入到反应混合物中。PDGF受体激酶活性是通过温浴10 μCi [33P]-ATP和l μM ATP 10分钟来确定。免疫复合物经SDS-PAGE上的7.5%凝胶上分离。
细胞实验:[3]
- 合并
  • Cell lines: BON-1 和 NCI-H727细胞
  • Concentrations: 约100 μM
  • Incubation Time: 48小时
  • Method: BON-1细胞和NCI-H727细胞接种到平底96孔板中三个复孔,并在含10%胎牛血清的DMEM或RPMI1640完全培养基中贴壁过夜,然后更换为血清培养基(阴性对照)或含不同浓度梯度Imatinib的无血清培养基。48小时(对照培养物没有达到汇合)后,代谢活性细胞的数量是由3-(4,5-二甲基吡啶-2-基)-2,5-二苯基溴化测定,由帕卡德光谱酶标仪测定540nm处吸光度。生长抑制通过以下公式计算:抑制率=(1 − a / b) × 100%,其中a和b分别是治疗组和对照组的吸光度值。
    (Only for Reference)
动物实验:[5]
- 合并
  • Animal Models: SCLC6, SCLC61, SCLC 74 and SCLC108 小细胞肺癌注入瑞士小鼠 (nu/nu, 雌性)。
  • Dosages: 70或100 mg/kg
  • Administration: 腹腔注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 118 mg/mL (200.09 mM)
Water 118 mg/mL (200.09 mM)
Ethanol Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 589.71
化学式

C29H31N7O.CH4SO3

CAS号 220127-57-1
储存条件 粉状
溶于溶剂
别名 Gleevec, Glivec, CGP-57148B

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02687425 Unknown status Drug: Pioglitazone|Drug: imatinib mesylate Leukemia Myelogenous Chronic BCR-ABL Positive Meng Li|Tongji Hospital February 2016 Phase 2
NCT02303899 Completed Drug: Gemcitabine|Drug: Imatinib mesylate Mesothelioma Malignant Istituto Clinico Humanitas November 2014 Phase 2
NCT01898377 Terminated Drug: Imatinib mesylate Mycophenolate mofetil Chronic Graft-versus-host Disease Seoul National University Hospital August 2013 Phase 2
NCT02891395 Completed Drug: Imatinib Mesylate and Nilotinib Graft Versus Host Disease University Hospital Lille|Novartis December 24 2012 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项
免费分装抑制剂

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

相关Bcr-Abl产品

Tags: 购买Imatinib (STI571) Mesylate | Imatinib (STI571) Mesylate供应商 | 采购Imatinib (STI571) Mesylate | Imatinib (STI571) Mesylate价格 | Imatinib (STI571) Mesylate生产 | 订购Imatinib (STI571) Mesylate | Imatinib (STI571) Mesylate代理商
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID