KU-55933 (ATM Kinase Inhibitor)

For research use only. Not for use in humans.

目录号：S1092

KU-55933 (ATM Kinase Inhibitor) Chemical Structure

CAS No. 587871-26-9

KU-55933 (ATM Kinase Inhibitor)是一种有效的，特异性ATM抑制剂，在无细胞试验中IC50/K_i为12.9 nM/2.2 nM，与DNA-PK， PI3K/PI4K， ATR和mTOR相比，对ATM具有高度选择性。KU‑55933 (ATM Kinase Inhibitor)可抑制 autophagy‑initiating kinase ULK1 的激活从而导致自噬的显著减少。

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10mM (1mL in DMSO)	RMB 917.23	现货
5mg	RMB 571.66	现货
10mg	RMB 975.88	现货
50mg	RMB 3032.31	现货
200mg	RMB 7755.93	现货
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客户使用Selleck生产的KU-55933 (ATM Kinase Inhibitor)发表文献276篇：

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产品安全说明书

ATM/ATR抑制剂选择性比较

生物活性

产品描述

靶点

ATM ^[1]
(Cell-free assay)

12.9 nM

体外研究

KU-55933是有效的特定ATM抑制剂，IC50为13 nM，K_i值为2.2 nM。KU-55933也抑制DNA-PK和PI3K，IC50分别为2.5和16.6 μM。KU-55933也抑制mTOR活性，IC50为9.3 μM。KU-55933有效作用于ATM依赖的磷酸化作用。KU-55933抑制ATM依赖的磷酸化作用，存在剂量依赖性，IC50为300 nM。小于30 μM时，KU-58050不能抑制p53的ATM-依赖性磷酸化作用（位点为第15位丝氨酸）。在UV-诱导的H2AX（位点为第139位丝氨酸）, NBS1（位点为第343为丝氨酸）, CHK1（位点为第345位丝氨酸）,及SMC1（位点为第966位丝氨酸）中，加入KU-55933没有明显作用效果。紫外处理时，KU-55933切除由电离辐射诱导的ATM磷酸化底物。KU-55933使HeLa细胞对电离辐射敏感。在癌细胞中，KU-55933抑制生长因子诱导的Akt的磷酸化作用。KU-55933抑制癌细胞增殖。KU-55933抑制ATM，通过阻断下游TAp63α的激活，提高存活力。^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
DU-145	NY\0e4diT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUP6dnVUUUN3ME2zMlI4OzV{IN88US=>	NYjGNXB3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HuO-3N1	NEOwW\|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVXJR\|UxRTRwMUexOFIh\|ryP	M{HxXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
LAMA-84	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NITrbllKSzVyPUSuOVg1PjVizszN	MnHsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
CAL-72	NWLXb4VrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFfiWFlKSzVyPUWuOFgxQDRizszN	MnLWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
LoVo	M4X2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn6yTWM2OD14LkmzNlM6KM7:TR?=	NHnhTng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
HH	NHnxfWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Ml;CTWM2OD16LkK3OlcyKM7:TR?=	NW\Jc\|ZlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
SK-MEL-3	NY\NWGJXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1nROWlEPTB;OD6yPFU4PSEQvF2=	MkXJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
KM12	NIG5V4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHj1UpFKSzVyPUmuNlEyPDJizszN	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NCI-H1437	NF7LNG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVrjRYg{UUN3ME25MlgxQTdizszN	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NCI-H1838	NGCzRXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mnv0TWM2OD1zMT6xPFY2KM7:TR?=	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
J-RT3-T3-5	NX25RXNTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlvQTWM2OD1zMT6yOFE4KM7:TR?=	M3XjWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
GOTO	NUHEdVVJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3jofmlEPTB;MUGuOlk6PiEQvF2=	M330XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
LB2241-RCC	NYXCZ294T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmO4TWM2OD1zMT63NVg3KM7:TR?=	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
ES7	M3P5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3u2bWlEPTB;MUGuO\|g5KM7:TR?=	M1XtRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
KP-N-YS	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3fPZWlEPTB;MUKuOlM2PCEQvF2=	NXj2U3FLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
CAL-12T	M2rZTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1rXcWlEPTB;MUOuOlE4KM7:TR?=	M3vFU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
COLO-684	M2XBeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3vxNGlEPTB;MUSuNVU3QSEQvF2=	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
DOK	NUL5N4ZvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYLJR\|UxRTF3LkOzNlkh\|ryP	NFfndFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
Hs-578-T	M3PHVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NF3hdJJKSzVyPUG1MlQyQDJizszN	Ml7iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
D-423MG	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{LmVGlEPTB;MUWuOVI{PiEQvF2=	NYrNRY9KRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
DBTRG-05MG	M{LwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWjJR\|UxRTF3Lk[xNVEh\|ryP	M2TTWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
VM-CUB-1	NH;Qb4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIjxenZKSzVyPUG1Mlk5PDlizszN	NYDMN\|lXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
KG-1	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHHZOIhKSzVyPUG2MlA6QTZizszN	NHzXTJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
8305C	MlTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnHHTWM2OD1zNj6xPFg6KM7:TR?=	NUniNJY3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HuH-7	NYS4VlM6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1vsSGlEPTB;MU[uNlY4PCEQvF2=	NVHRe5JuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
LXF-289	M4XI[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHTUWXJKSzVyPUG2MlI4PDdizszN	M{HyfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
NCI-H1793	MoHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnHtTWM2OD1zNj60O\|EzKM7:TR?=	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
ChaGo-K-1	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1nnVGlEPTB;MU[uOlU3QCEQvF2=	NF\YVYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
GCIY	NXXOO\|UyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1P2fmlEPTB;MU[uO\|kxPSEQvF2=	NH7vXG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
SK-MEL-28	M{H0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXjJR\|UxRTF5LkC0O\|Uh\|ryP	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NCI-SNU-1	NHrCSFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVnFVYRlUUN3ME2xO{4yOjZ7IN88US=>	NXG5cFFtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
CTB-1	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4K0W2lEPTB;MUeuNlI2QSEQvF2=	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NCI-H82	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHzPbo1KSzVyPUG3MlQ2PzNizszN	NYjMcnA5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HCC2998	NFi0V3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3ex[mlEPTB;MUeuOlc{OyEQvF2=	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NCI-H2030	NXLXXItIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NV;Uc25LUUN3ME2xPE4yQTl5IN88US=>	MnLOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
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HepG2	NIG4dYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVnWS3NLOTEEoN88US=>	NFXkOHEzPCCq		NXPnVIN2[myxY3vzJHNENUmLSUOtbY5lfWOnZDDTJJBp[XOnIHHydoV{fA>?	NHLKUlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUWyO\|EzOyd-MkW1NlcyOjN:L3G+
HepG2	NVzPZW5JTnWwY4Tpc44hSXO\|YYm=	NGPrfIgyOMLizszN	NGK0NZQzPCCq		MoG5d5VxeHKnc4Pld{B1cGVicHjvd5Bpd3K7bHH0bY9veyCxZjDBWG0hd25iU3XyNVk5OSxiQ3jrNUBwdiCVZYKzOFUtKEOqa{Kgc44hXGi{NkisJIFv\CCFZHuyJI9vKFS7ckG1JIlv\HWlZXSgZpkhW0NvSVnJNy=>	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTV{N{GyN{c,OjV3MkexNlM9N2F-
KATO III	MmTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkP6Nk42NzVxNz61JO69VQ>?		MVHEUXNQ	Mne0[Y5p[W6lZYOgeIhmKHSxeHnjbZR6KG:oIH;sZZBiemmk	NX7aclJqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4OFE4OThpPkK0PFQyPzF6PD;hQi=>
hTCEpi	M1LsRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1LkR\|ExKM7:TR?=		MVnEUXNQ	M4DNV5Bz\X[nboTzJJRp\SCleYTvdIF1cGmlIHXm[oVkfCCxZjDIV3YuOQ>?	NXuzNnFLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzO\|A5OzVpPkK0N\|cxQDN3PD;hQi=>
MCF10A	M4Pqemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYj6O2t[OTBizszN	NXvKZnJoOjRiaB?=	MUXEUXNQ	NGn5b2hxd3SnboTpZZRmeyC2aHWgZ5l1d3SxeHnjbZR6KG:oIFfB	M1TGZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUWwOVk2Lz5{NEG1NFU6PTxxYU6=
HL-60	MoLsSpVv[3Srb36gRZN{[Xl?	NI\uNmgyOCEQvF2=	M3vLe\|AvPSCq	M2\MeGROW09?	NGWySm5z\WS3Y3XzJJBpd3OyaH;yfYxifGmxbjDv[kBEcGt{wrC=	MnWyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7M{S0NVEoRjJ\|OUO0OFEyRC:jPh?=
MCF-7	MlK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnOzNU0yODEQvF2=	MlXaNlQhcA>?	NHO2bnVHSlN?	M3nQcolvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25?	NYeyT5B3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxPFU{PDdpPkKzNVg2OzR5PD;hQi=>
HeLa	NXj0W3N4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHr6cmcyNTFyMN88US=>	MljoNlQhcA>?	Mn;WSmJU	NV\u[IVycW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbh?=	M3;yXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MUi1N\|Q4Lz5{M{G4OVM1PzxxYU6=
SH-SY5Y	NGn5bplHfW6ldHnvckBCe3OjeR?=	NWC1WXVkOTEEoN88UeKh	MoP0NlQhcA>?		MYnpcohq[mm2czDjcIlweXWrbn;sMYlv\HWlZXSgdIhwe3Cqb4L5cIF1cW:wIH;mJJA2Ow>?	M4XmdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NkK3Nlk1Lz5{Mk[yO\|I6PDxxYU6=
IMR-32	MkTpSpVv[3Srb36gRZN{[Xl?	NF;sZ2YyOMLizszNxsA>	NGWzdXIzPCCq		MljTbY5pcWKrdIOgZ4xqd3G3aX7vcE1qdmS3Y3XkJJBpd3OyaH;yfYxifGmxbjDv[kBxPTN?	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZ{N{K5OEc,OjJ4MkeyPVQ9N2F-
A549	NIjSRWRHfW6ldHnvckBCe3OjeR?=	NGrlZXkyOMLizszNxsA>	MnL5NUBp		NFPxT2l{fXCycnXzd4V{KE6jbn:tR48ucW6mdXPl[EBxPTNiYXPjeY12dGG2aX;u	MoHwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3NUmzNlEoRjJ{NUW5N\|IyRC:jPh?=
T47D	NHK0WoNHfW6ldHnvckBCe3OjeR?=	NFi5NlEzOMLibV2=	MnLLNlQhcA>?	MWfEUXNQ	MmO2dJJmfmWwdIOgTXIucW6mdXPl[EBl\We{YXTheIlwdiCxZjDJ{tpD\|rF?	NGnZN3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUG0OFgxPSd-MkGxOFQ5ODV:L3G+
A29 MEF	NVOwNIRLTnWwY4Tpc44hSXO\|YYm=	MWKxNOKh\|ryPwrC=	M1G5VlFp		MWricI9kc3QEoITo[UBxcG:\|cHjvdplt[XSrb36gc4YhSWu2IHH0JHNmejR5M9Mg	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB3M{e4NUc,OjByNUO3PFE9N2F-
MDA-MB-453	MoXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV3OTmZHPS12MDFOwG0>	MnTIO\|IhcA>?		NIHkVIZKSzVyIH;mJFExKM7:TR?=	NVnUc2FuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOVM4QDFpPkKwNFU{PzhzPD;hQi=>
PC-3	NGTQ[nFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXTUTHNrPS12MDFOwG0>	NVnNXG9jPzJiaB?=		NGXLZmJKSzVyIH;mJFExKM7:TR?=	NX;NT4lmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOVM4QDFpPkKwNFU{PzhzPD;hQi=>
U2OS	NX;xOndjTnWwY4Tpc44h[XO\|YYm=				MUnJcohq[mm2aX;uJI9nKEGWTTDpckBpfW2jbjDVNm9UKGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gdFU{KHCqb4PwbI9zgWyjdHnvckBifCCVZYKxOUBz\XOrZIXlMEBKSzVyIE2gNE4zPSEQvF2u	MmTPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4M{K5OlUoRjJ4NkOyPVY2RC:jPh?=
MCF7	Mo\YSpVv[3Srb36gZZN{[Xl?		NV;KUppyOSCqch?=		MUDJcohq[mm2aX;uJI9nKEGWTTDrbY5ie2ViaX6gbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiBzIHjyJIJ6KGmvbYXuc4ZtfW:{ZYPj[Y5k\SCjc4PhfUwhUUN3MDC9JFAvOyEQvF2u	NXXRdlRSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2N\|I6PjVpPkK2OlMzQTZ3PD;hQi=>
BJ	MXjGeY5kfGmxbjDhd5NigQ>?	NVvBNlR7OTBidV2=	NHvXRncyOCCmYYnz		M3rlU3N2eHC{ZYPzbY9vKG:oIIPlcoV{[2WwY3WgbY4hcHWvYX6gRmoh[2WubIOgZZN{\XO\|ZXSgZZMhcW6lcnXhd4UhcW5iY3XscEBvfW2kZYKgZZQhOTBidV2gZYZ1\XJiMUCg[IF6eyCkeTDz[Y5me2OnbnPlJJJmfmW{c3HsJIF{e2G7	NELQUpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNke2O\|A5PSd-MU[3OlcxQDV:L3G+
BJ	NUnLfll[TnWwY4Tpc44h[XO\|YYm=	NXHGb3dGOTBidV2=	MWSxNEBl[Xm\|		MXfJcohq[mm2aX;uJI9nKGG2YYjpZUB1\Wyjbnfp[YN1[XOrYT3teZRifGWmIHnuJIh2dWGwIFLKJINmdGy\|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGOnbHygcpVu[mW{IHH0JFExKHWPIHHmeIVzKDFyIHThfZMh[nlic3Xu[ZNk\W6lZTDy[ZZmenOjbDDhd5NigQ>?	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd4N{C4OUc,OTZ5NkewPFU9N2F-
MCF7	MYXGeY5kfGmxbjDhd5NigQ>?	NGHxc2oyOCC3TR?=	M4fJ[VExKG2rboO=		M4fYWHNmdnOrdHn6ZZRqd25ib3[gbY5nemG{ZXStbY5lfWOnZDDEUmEh\GGvYXflJIlvKGi3bXHuJG1ETjdiY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINwdG:weTDmc5Ju[XSrb36gZZQhOTBidV2gdJJmfHKnYYTl[EBnd3JiMUCgcYlveyCob3zsc5dm\CCkeTDpdpJi\GmjdHnvckBnd3JiNDDodpMhdWWjc4Xy[YQh[W[2ZYKgNVAh\GG7czDifUBkenm\|dHHsJJZqd2yndDDzeIFqdmmwZzDhcoFtgXOrcx?=	NIHSXWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[zNlk3PSd-Mk[2N\|I6PjV:L3G+
SK-N-MC	NUnOc4IzeUiWUzDhd5NigQ>?				NEDCVW1yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1OSyClZXzsdy=>	NIK3[o09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-AKT(Ser473) / p-AKT(Thr308); PubMed: 22739265 Chin J Cancer Cells were serum-starved for 6 h and treated with KU-55933 (10 µmol/L) for 1 h before treatment with insulin (100 nmol/L) for 45 min. Cells were lysed, and cell lysates were subjected to SDS-PAGE and Western blotting for the detection of phospho-Akt at Se䲧疝Ỵ疞㧀疜膉痘瘿�෋ᾰƌ෋à㺣痖 PARP / Cleaved PARP / Caspase-3 / Cleaved caspase-3 ; PubMed: 22739265 Chin J Cancer ATM inhibition by KU-55933 induces apoptosis in differentiated but not undifferentiated SH-SY5Y cells. Cells were starved for 6 h in serum-free medium. KU-55933 (10 µmol/L) was added 1 h before insulin (100 nmol/L) treatment. After 3 h of insulin stimulat䲧疝Ỵ疞㧀疜膉痘瘿�෋ᾰƌ෋à㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤 ATM-S1981 / ATM / p-p53(S15) / p53 ; PubMed: 20639198 J Biol Chem Antioxidant and ATM inhibitors blocked phosphorylation of ATM-S1981, Akt-S473, and p53-S15 as stimulated by H2O2 exposure. Cells were treated with 100 μm H2O2 for 30 min in the absence or presence of KU-55933. Whole cell lysates were subjected to Western 䲧疝Ỵ疞㧀疜膉痘瘿뾠ՂᾰƌՂĀ㺣痖 p21 / p27 / p53 ; PubMed: 20177072 J Biol Chem HMGE cells were incubated for the indicated times with 1 μm KU-55933 or DMSO. Total protein extracts were analyzed by Western blotting for p21WAF1/CIP1, p27KIP1, p53, or β-actin.	22739265 20639198 20177072
Immunofluorescence	p-S824 KAP1 / ZEBRA ; PubMed: 28249048 PLoS Pathog HH514-16 cells were treated with NaB (upper panel) or NaB plus KU-55933 (1μM; middle panel) or NaB plus Torin1 (0.5μM; lower panel) for 24 hours and stained with anti-phospho KAP1 (S824) plus anti-ZEBRA antibodies and visualized at 1000X magnification.	28249048

体内研究

KU-55933抑制ATM依赖的STAT3激活，通过上调DR5表达增强TRAIL调节的凋亡,抑制STAT3 和NF-κB都和下调cFLIP有关，伴随着凋亡水平上升。ATM抑制剂KU-55933 影响TRAIL调节的凋亡的效果比JAK2抑制剂AG490或STAT3β过量表达都高。^[3]

激酶实验： ^[1]	- 合并纯化的酶实验: 通过免疫沉淀反应从HeLa核蛋白萃取中获得用于体外研究的ATM，在反应buffer中，把兔多克隆抗血清加到ATM羧基端第400个氨基酸处，buffer包含25 mM HEPES (pH为7.4), 2 mM MgCl₂, 250 mM KCl, 500 μM EDTA, 100 μM Na₃VO₄, 10% v/v 甘油, 及0.1% v/v Igepal。和蛋白A凝胶温育1小时，然后进行离心作用，从核蛋白中分离ATM抗体复合物。在96孔板中，包含ATM的凝胶珠和1 μg 底物GST-p53N66 (p53的氮端第66位氨基酸与GST融合)在ATM实验buffer中37^oC下温育，buffer包括25 mM HEPES (pH 为7.4), 75 mM NaCl, 3 mM MgCl₂, 2 mM MnCl₂, 50 μM Na₃VO₄, 500 μM DTT, 及5% v/v甘油。震荡10分钟后，加入ATP，最终浓度为50 μM，在37^oC反应持续1小时。按250×g转速4^oC下离心10分钟，除去ATM凝胶珠，上清液转移到96孔板上，在室温下温育1.5小时。然后用PBS冲洗，烘干，加入p-p53(Ser15)抗体用于ELISA分析。使用增强的化学发光溶液产生信号和化学发光。
细胞实验： ^[1]	- 合并 Cell lines: U2OS细胞 Concentrations: 10 μM Incubation Time: 2小时 Method: U2OS细胞经过电离辐射(3, 5, 或15 Gy) 或者UV处理(5或50 J/m2)，通过p-p53（Ser15）和p53 的Western blot分析而测定ATM反应。在不同时间点获得细胞萃取物，SDS-PAGE分离蛋白，加入p-p53(Ser15)抗体，ATM增多。加入p53抗体观察到p53随着时间变化趋于稳定。为了测定KU-55933的IC50值，使用p-p53(Ser15)抗体检测KU-55933抑制ATM的效果。KU-55933加到细胞中，预温育1小时，然后进行电离辐射。在体外，使用扫描密度测定法测定IC50值。 (Only for Reference)
动物实验： ^[3]	- 合并 Animal Models: 携带LU1205细胞的BALB/c nu/nu鼠 Dosages: 10 μM Administration: -- (Only for Reference)

参考文献

溶解度 (25°C)

体外	DMSO	33 mg/mL (83.44 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 5%DMSO+40%PEG300+5%Tween80+50%ddH2O	3.95 mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download KU-55933 (ATM Kinase Inhibitor) SDF

分子量	395.49
化学式	C₂₁H₁₇NO₃S₂
CAS号	587871-26-9
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

技术支持

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操作手册

如果有其他问题，请给我们留言。

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用于临床的ATM/ATR抑制剂

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最新的ATM/ATR抑制剂

VE-822 ^New : ATR inhibitor with IC50 of 19 nM.

研究领域

产品类型

定制您的化合物库

KU-55933 (ATM Kinase Inhibitor)

客户使用Selleck生产的KU-55933 (ATM Kinase Inhibitor)发表文献276篇：

产品安全说明书

ATM/ATR抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download KU-55933 (ATM Kinase Inhibitor) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

技术支持

ATM/ATR Signaling Pathway Map

ATM/ATR Inhibitors with Unique Features

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