KU-55933 (ATM Kinase Inhibitor)

For research use only. Not for use in humans.

目录号:S1092

KU-55933 (ATM Kinase Inhibitor) Chemical Structure

CAS No. 587871-26-9

KU-55933 (ATM Kinase Inhibitor)是一种有效的,特异性ATM抑制剂,在无细胞试验中IC50/Ki为12.9 nM/2.2 nM,与DNA-PK, PI3K/PI4K, ATR和mTOR相比,对ATM具有高度选择性。KU‑55933 (ATM Kinase Inhibitor)可抑制 autophagy‑initiating kinase ULK1 的激活从而导致自噬的显著减少。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 917.23 现货
RMB 571.66 现货
RMB 975.88 现货
RMB 3032.31 现货
RMB 7755.93 现货
有超大折扣
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客户使用Selleck生产的KU-55933 (ATM Kinase Inhibitor)发表文献276篇:

产品安全说明书

ATM/ATR抑制剂选择性比较

生物活性

产品描述 KU-55933 (ATM Kinase Inhibitor)是一种有效的,特异性ATM抑制剂,在无细胞试验中IC50/Ki为12.9 nM/2.2 nM,与DNA-PK, PI3K/PI4K, ATR和mTOR相比,对ATM具有高度选择性。KU‑55933 (ATM Kinase Inhibitor)可抑制 autophagy‑initiating kinase ULK1 的激活从而导致自噬的显著减少。
靶点
ATM [1]
(Cell-free assay)
12.9 nM
体外研究

KU-55933是有效的特定ATM抑制剂,IC50为13 nM,Ki值为2.2 nM。KU-55933也抑制DNA-PK和PI3K,IC50分别为2.5和16.6 μM。KU-55933也抑制mTOR活性,IC50为9.3 μM。KU-55933有效作用于ATM依赖的磷酸化作用。KU-55933抑制ATM依赖的磷酸化作用,存在剂量依赖性,IC50为300 nM。小于30 μM时,KU-58050不能抑制p53的ATM-依赖性磷酸化作用(位点为第15位丝氨酸)。在UV-诱导的H2AX(位点为第139位丝氨酸), NBS1(位点为第343为丝氨酸), CHK1(位点为第345位丝氨酸),及SMC1(位点为第966位丝氨酸)中,加入KU-55933没有明显作用效果。紫外处理时,KU-55933切除由电离辐射诱导的ATM磷酸化底物。KU-55933使HeLa细胞对电离辐射敏感。在癌细胞中,KU-55933抑制生长因子诱导的Akt的磷酸化作用。KU-55933抑制癌细胞增殖。KU-55933抑制ATM,通过阻断下游TAp63α的激活,提高存活力。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
DU-145 NY\0e4diT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUP6dnVUUUN3ME2zMlI4OzV{IN88US=> NYjGNXB3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HuO-3N1 NEOwW|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTRwMUexOFIh|ryP M{HxXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
LAMA-84 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITrbllKSzVyPUSuOVg1PjVizszN MnHsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
CAL-72 NWLXb4VrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfiWFlKSzVyPUWuOFgxQDRizszN MnLWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
LoVo M4X2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn6yTWM2OD14LkmzNlM6KM7:TR?= NHnhTng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
HH NHnxfWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;CTWM2OD16LkK3OlcyKM7:TR?= NW\Jc|ZlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
SK-MEL-3 NY\NWGJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nROWlEPTB;OD6yPFU4PSEQvF2= MkXJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
KM12 NIG5V4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHj1UpFKSzVyPUmuNlEyPDJizszN MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NCI-H1437 NF7LNG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrjRYg{UUN3ME25MlgxQTdizszN MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NCI-H1838 NGCzRXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnv0TWM2OD1zMT6xPFY2KM7:TR?= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
J-RT3-T3-5 NX25RXNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvQTWM2OD1zMT6yOFE4KM7:TR?= M3XjWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
GOTO NUHEdVVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jofmlEPTB;MUGuOlk6PiEQvF2= M330XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
LB2241-RCC NYXCZ294T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmO4TWM2OD1zMT63NVg3KM7:TR?= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
ES7 M3P5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3u2bWlEPTB;MUGuO|g5KM7:TR?= M1XtRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
KP-N-YS MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fPZWlEPTB;MUKuOlM2PCEQvF2= NXj2U3FLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
CAL-12T M2rZTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rXcWlEPTB;MUOuOlE4KM7:TR?= M3vFU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
COLO-684 M2XBeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vxNGlEPTB;MUSuNVU3QSEQvF2= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
DOK NUL5N4ZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTF3LkOzNlkh|ryP NFfndFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
Hs-578-T M3PHVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3hdJJKSzVyPUG1MlQyQDJizszN Ml7iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
D-423MG MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LmVGlEPTB;MUWuOVI{PiEQvF2= NYrNRY9KRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
DBTRG-05MG M{LwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTF3Lk[xNVEh|ryP M2TTWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
VM-CUB-1 NH;Qb4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjxenZKSzVyPUG1Mlk5PDlizszN NYDMN|lXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
KG-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHZOIhKSzVyPUG2MlA6QTZizszN NHzXTJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
8305C MlTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHHTWM2OD1zNj6xPFg6KM7:TR?= NUniNJY3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HuH-7 NYS4VlM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vsSGlEPTB;MU[uNlY4PCEQvF2= NVHRe5JuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
LXF-289 M4XI[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTUWXJKSzVyPUG2MlI4PDdizszN M{HyfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
NCI-H1793 MoHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHtTWM2OD1zNj60O|EzKM7:TR?= MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
ChaGo-K-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nnVGlEPTB;MU[uOlU3QCEQvF2= NF\YVYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
GCIY NXXOO|UyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1P2fmlEPTB;MU[uO|kxPSEQvF2= NH7vXG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
SK-MEL-28 M{H0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTF5LkC0O|Uh|ryP MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NCI-SNU-1 NHrCSFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnFVYRlUUN3ME2xO{4yOjZ7IN88US=> NXG5cFFtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
CTB-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4K0W2lEPTB;MUeuNlI2QSEQvF2= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NCI-H82 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzPbo1KSzVyPUG3MlQ2PzNizszN NYjMcnA5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HCC2998 NFi0V3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ex[mlEPTB;MUeuOlc{OyEQvF2= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NCI-H2030 NXLXXItIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;Uc25LUUN3ME2xPE4yQTl5IN88US=> MnLOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
HuP-T3 NWWwbHh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFWyc4xKSzVyPUG4MlU5QDhizszN MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
697 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTF7LkCyNFEh|ryP MkHIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
MLMA M1fkb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUWxbZVVUUN3ME2xPU4xPTV5IN88US=> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
HCC70 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTF7LkS4PUDPxE1? MlTpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
A704 NFz3dJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\lXWlEPTB;MUmuPFMxPSEQvF2= NH\ZO4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
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KALS-1 MoPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTR3LkG0OkDPxE1? NYrzeYJ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
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EPLC-272H M323VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTR4Lkm1NFMh|ryP MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
BALL-1 NXm2bHNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTDTWM2OD12Nz64N|Ih|ryP M3TqRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
LCLC-97TM1 NIfRSHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTkfWZ5UUN3ME20PE4zODJizszN Ml7HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
HO-1-N-1 NHTGSo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVmyU5hwUUN3ME20PE46Pjd4IN88US=> M1j1UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
MFE-280 NInLUHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvLU5FyUUN3ME20PU41PjF5IN88US=> M3nTTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
NCI-H526 M2PkeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTR7LkixOlMh|ryP M2WyVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
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BB30-HNC Mn72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXyPHlKSzVyPUS5Mlk1QThizszN MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
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HepG2  NIG4dYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnWS3NLOTEEoN88US=> NFXkOHEzPCCq NXPnVIN2[myxY3vzJHNENUmLSUOtbY5lfWOnZDDTJJBp[XOnIHHydoV{fA>? NHLKUlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUWyO|EzOyd-MkW1NlcyOjN:L3G+
HepG2  NVzPZW5JTnWwY4Tpc44hSXO|YYm= NGPrfIgyOMLizszN NGK0NZQzPCCq MoG5d5VxeHKnc4Pld{B1cGVicHjvd5Bpd3K7bHH0bY9veyCxZjDBWG0hd25iU3XyNVk5OSxiQ3jrNUBwdiCVZYKzOFUtKEOqa{Kgc44hXGi{NkisJIFv\CCFZHuyJI9vKFS7ckG1JIlv\HWlZXSgZpkhW0NvSVnJNy=> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTV{N{GyN{c,OjV3MkexNlM9N2F-
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HL-60  MoLsSpVv[3Srb36gRZN{[Xl? NI\uNmgyOCEQvF2= M3vLe|AvPSCq M2\MeGROW09? NGWySm5z\WS3Y3XzJJBpd3OyaH;yfYxifGmxbjDv[kBEcGt{wrC= MnWyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7M{S0NVEoRjJ|OUO0OFEyRC:jPh?=
MCF-7 MlK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnOzNU0yODEQvF2= MlXaNlQhcA>? NHO2bnVHSlN? M3nQcolvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25? NYeyT5B3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxPFU{PDdpPkKzNVg2OzR5PD;hQi=>
HeLa  NXj0W3N4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHr6cmcyNTFyMN88US=> MljoNlQhcA>? Mn;WSmJU NV\u[IVycW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbh?= M3;yXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MUi1N|Q4Lz5{M{G4OVM1PzxxYU6=
SH-SY5Y NGn5bplHfW6ldHnvckBCe3OjeR?= NWC1WXVkOTEEoN88UeKh MoP0NlQhcA>? MYnpcohq[mm2czDjcIlweXWrbn;sMYlv\HWlZXSgdIhwe3Cqb4L5cIF1cW:wIH;mJJA2Ow>? M4XmdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NkK3Nlk1Lz5{Mk[yO|I6PDxxYU6=
IMR-32 MkTpSpVv[3Srb36gRZN{[Xl? NF;sZ2YyOMLizszNxsA> NGWzdXIzPCCq MljTbY5pcWKrdIOgZ4xqd3G3aX7vcE1qdmS3Y3XkJJBpd3OyaH;yfYxifGmxbjDv[kBxPTN? MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZ{N{K5OEc,OjJ4MkeyPVQ9N2F-
A549 NIjSRWRHfW6ldHnvckBCe3OjeR?= NGrlZXkyOMLizszNxsA> MnL5NUBp NFPxT2l{fXCycnXzd4V{KE6jbn:tR48ucW6mdXPl[EBxPTNiYXPjeY12dGG2aX;u MoHwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3NUmzNlEoRjJ{NUW5N|IyRC:jPh?=
T47D  NHK0WoNHfW6ldHnvckBCe3OjeR?= NFi5NlEzOMLibV2= MnLLNlQhcA>? MWfEUXNQ MmO2dJJmfmWwdIOgTXIucW6mdXPl[EBl\We{YXTheIlwdiCxZjDJ{tpD|rF? NGnZN3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUG0OFgxPSd-MkGxOFQ5ODV:L3G+
A29 MEF NVOwNIRLTnWwY4Tpc44hSXO|YYm= MWKxNOKh|ryPwrC= M1G5VlFp MWricI9kc3QEoITo[UBxcG:|cHjvdplt[XSrb36gc4YhSWu2IHH0JHNmejR5M9Mg MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB3M{e4NUc,OjByNUO3PFE9N2F-
MDA-MB-453  MoXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3OTmZHPS12MDFOwG0> MnTIO|IhcA>? NIHkVIZKSzVyIH;mJFExKM7:TR?= NVnUc2FuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOVM4QDFpPkKwNFU{PzhzPD;hQi=>
PC-3 NGTQ[nFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTUTHNrPS12MDFOwG0> NVnNXG9jPzJiaB?= NGXLZmJKSzVyIH;mJFExKM7:TR?= NX;NT4lmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOVM4QDFpPkKwNFU{PzhzPD;hQi=>
U2OS NX;xOndjTnWwY4Tpc44h[XO|YYm= MUnJcohq[mm2aX;uJI9nKEGWTTDpckBpfW2jbjDVNm9UKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gdFU{KHCqb4PwbI9zgWyjdHnvckBifCCVZYKxOUBz\XOrZIXlMEBKSzVyIE2gNE4zPSEQvF2u MmTPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4M{K5OlUoRjJ4NkOyPVY2RC:jPh?=
MCF7 Mo\YSpVv[3Srb36gZZN{[Xl? NV;KUppyOSCqch?= MUDJcohq[mm2aX;uJI9nKEGWTTDrbY5ie2ViaX6gbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiBzIHjyJIJ6KGmvbYXuc4ZtfW:{ZYPj[Y5k\SCjc4PhfUwhUUN3MDC9JFAvOyEQvF2u NXXRdlRSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2N|I6PjVpPkK2OlMzQTZ3PD;hQi=>
BJ MXjGeY5kfGmxbjDhd5NigQ>? NVvBNlR7OTBidV2= NHvXRncyOCCmYYnz M3rlU3N2eHC{ZYPzbY9vKG:oIIPlcoV{[2WwY3WgbY4hcHWvYX6gRmoh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iY3XscEBvfW2kZYKgZZQhOTBidV2gZYZ1\XJiMUCg[IF6eyCkeTDz[Y5me2OnbnPlJJJmfmW{c3HsJIF{e2G7 NELQUpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNke2O|A5PSd-MU[3OlcxQDV:L3G+
BJ NUnLfll[TnWwY4Tpc44h[XO|YYm= NXHGb3dGOTBidV2= MWSxNEBl[Xm| MXfJcohq[mm2aX;uJI9nKGG2YYjpZUB1\Wyjbnfp[YN1[XOrYT3teZRifGWmIHnuJIh2dWGwIFLKJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGOnbHygcpVu[mW{IHH0JFExKHWPIHHmeIVzKDFyIHThfZMh[nlic3Xu[ZNk\W6lZTDy[ZZmenOjbDDhd5NigQ>? MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd4N{C4OUc,OTZ5NkewPFU9N2F-
MCF7 MYXGeY5kfGmxbjDhd5NigQ>? NGHxc2oyOCC3TR?= M4fJ[VExKG2rboO= M4fYWHNmdnOrdHn6ZZRqd25ib3[gbY5nemG{ZXStbY5lfWOnZDDEUmEh\GGvYXflJIlvKGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINwdG:weTDmc5Ju[XSrb36gZZQhOTBidV2gdJJmfHKnYYTl[EBnd3JiMUCgcYlveyCob3zsc5dm\CCkeTDpdpJi\GmjdHnvckBnd3JiNDDodpMhdWWjc4Xy[YQh[W[2ZYKgNVAh\GG7czDifUBkenm|dHHsJJZqd2yndDDzeIFqdmmwZzDhcoFtgXOrcx?= NIHSXWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[zNlk3PSd-Mk[2N|I6PjV:L3G+
SK-N-MC NUnOc4IzeUiWUzDhd5NigQ>? NEDCVW1yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1OSyClZXzsdy=> NIK3[o09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT(Ser473) / p-AKT(Thr308); 

PubMed: 22739265     


Cells were serum-starved for 6 h and treated with KU-55933 (10 µmol/L) for 1 h before treatment with insulin (100 nmol/L) for 45 min. Cells were lysed, and cell lysates were subjected to SDS-PAGE and Western blotting for the detection of phospho-Akt at Se䲧疝Ỵ疞㧀疜膉痘瘿�෋ᾰƌ෋à㺣痖

PARP / Cleaved PARP / Caspase-3 / Cleaved caspase-3 ; 

PubMed: 22739265     


ATM inhibition by KU-55933 induces apoptosis in differentiated but not undifferentiated SH-SY5Y cells. Cells were starved for 6 h in serum-free medium. KU-55933 (10 µmol/L) was added 1 h before insulin (100 nmol/L) treatment. After 3 h of insulin stimulat䲧疝Ỵ疞㧀疜膉痘瘿�෋ᾰƌ෋à㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤

ATM-S1981 / ATM / p-p53(S15) / p53 ; 

PubMed: 20639198     


Antioxidant and ATM inhibitors blocked phosphorylation of ATM-S1981, Akt-S473, and p53-S15 as stimulated by H2O2 exposure. Cells were treated with 100 μm H2O2 for 30 min in the absence or presence of KU-55933. Whole cell lysates were subjected to Western 䲧疝Ỵ疞㧀疜膉痘瘿뾠ՂᾰƌՂĀ㺣痖

p21 / p27 / p53 ; 

PubMed: 20177072     


HMGE cells were incubated for the indicated times with 1 μm KU-55933 or DMSO. Total protein extracts were analyzed by Western blotting for p21WAF1/CIP1, p27KIP1, p53, or β-actin.

22739265 20639198 20177072
Immunofluorescence
p-S824 KAP1 / ZEBRA ; 

PubMed: 28249048     


HH514-16 cells were treated with NaB (upper panel) or NaB plus KU-55933 (1μM; middle panel) or NaB plus Torin1 (0.5μM; lower panel) for 24 hours and stained with anti-phospho KAP1 (S824) plus anti-ZEBRA antibodies and visualized at 1000X magnification.

28249048
体内研究 KU-55933抑制ATM依赖的STAT3激活,通过上调DR5表达增强TRAIL调节的凋亡,抑制STAT3 和NF-κB都和下调cFLIP有关,伴随着凋亡水平上升。ATM抑制剂KU-55933 影响TRAIL调节的凋亡的效果比JAK2抑制剂AG490或STAT3β过量表达都高。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

纯化的酶实验:

通过免疫沉淀反应从HeLa核蛋白萃取中获得用于体外研究的ATM,在反应buffer中,把兔多克隆抗血清加到ATM羧基端第400个氨基酸处,buffer包含25 mM HEPES (pH为7.4), 2 mM MgCl2, 250 mM KCl, 500 μM EDTA, 100 μM Na3VO4, 10% v/v 甘油, 及0.1% v/v Igepal。和蛋白A凝胶温育1小时,然后进行离心作用,从核蛋白中分离ATM抗体复合物。在96孔板中,包含ATM的凝胶珠和1 μg 底物GST-p53N66 (p53的氮端第66位氨基酸与GST融合)在ATM实验buffer中37oC下温育,buffer包括25 mM HEPES (pH 为7.4), 75 mM NaCl, 3 mM MgCl2, 2 mM MnCl2, 50 μM Na3VO4, 500 μM DTT, 及5% v/v甘油。震荡10分钟后,加入ATP,最终浓度为50 μM,在37oC反应持续1小时。按250×g转速4oC下离心10分钟,除去ATM凝胶珠,上清液转移到96孔板上,在室温下温育1.5小时。然后用PBS冲洗,烘干,加入p-p53(Ser15)抗体用于ELISA分析。使用增强的化学发光溶液产生信号和化学发光。
细胞实验:

[1]

- 合并
  • Cell lines: U2OS细胞
  • Concentrations: 10 μM
  • Incubation Time: 2小时
  • Method:

    U2OS细胞经过电离辐射(3, 5, 或15 Gy) 或者UV处理(5或50 J/m2),通过p-p53(Ser15)和p53 的Western blot分析而测定ATM反应。在不同时间点获得细胞萃取物,SDS-PAGE分离蛋白,加入p-p53(Ser15)抗体,ATM增多。加入p53抗体观察到p53随着时间变化趋于稳定。为了测定KU-55933的IC50值,使用p-p53(Ser15)抗体检测KU-55933抑制ATM的效果。KU-55933加到细胞中,预温育1小时,然后进行电离辐射。在体外,使用扫描密度测定法测定IC50值。


    (Only for Reference)
动物实验:

[3]

- 合并
  • Animal Models: 携带LU1205细胞的BALB/c nu/nu鼠
  • Dosages: 10 μM
  • Administration: --
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 33 mg/mL (83.44 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5%DMSO+40%PEG300+5%Tween80+50%ddH2O
3.95 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 395.49
化学式

C21H17NO3S2

CAS号 587871-26-9
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

ATM/ATR Signaling Pathway Map

ATM/ATR Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID