KU-55933 (ATM Kinase Inhibitor)

For research use only. Not for use in humans.

目录号:S1092

KU-55933 (ATM Kinase Inhibitor) Chemical Structure

CAS No. 587871-26-9

KU-55933 (ATM Kinase Inhibitor)是一种有效的,特异性ATM抑制剂,在无细胞试验中IC50/Ki为12.9 nM/2.2 nM,与DNA-PK, PI3K/PI4K, ATR和mTOR相比,对ATM具有高度选择性。KU‑55933 (ATM Kinase Inhibitor)可抑制 autophagy‑initiating kinase ULK1 的激活从而导致自噬的显著减少。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 917.23 现货
RMB 571.66 现货
RMB 975.88 现货
RMB 3032.31 现货
RMB 7755.93 现货
有超大折扣

今日订购,明日送达,全国免运费!

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的KU-55933 (ATM Kinase Inhibitor)发表文献237篇:

产品安全说明书

ATM/ATR抑制剂选择性比较

生物活性

产品描述 KU-55933 (ATM Kinase Inhibitor)是一种有效的,特异性ATM抑制剂,在无细胞试验中IC50/Ki为12.9 nM/2.2 nM,与DNA-PK, PI3K/PI4K, ATR和mTOR相比,对ATM具有高度选择性。KU‑55933 (ATM Kinase Inhibitor)可抑制 autophagy‑initiating kinase ULK1 的激活从而导致自噬的显著减少。
靶点
ATM [1]
(Cell-free assay)
12.9 nM
体外研究

KU-55933是有效的特定ATM抑制剂,IC50为13 nM,Ki值为2.2 nM。KU-55933也抑制DNA-PK和PI3K,IC50分别为2.5和16.6 μM。KU-55933也抑制mTOR活性,IC50为9.3 μM。KU-55933有效作用于ATM依赖的磷酸化作用。KU-55933抑制ATM依赖的磷酸化作用,存在剂量依赖性,IC50为300 nM。小于30 μM时,KU-58050不能抑制p53的ATM-依赖性磷酸化作用(位点为第15位丝氨酸)。在UV-诱导的H2AX(位点为第139位丝氨酸), NBS1(位点为第343为丝氨酸), CHK1(位点为第345位丝氨酸),及SMC1(位点为第966位丝氨酸)中,加入KU-55933没有明显作用效果。紫外处理时,KU-55933切除由电离辐射诱导的ATM磷酸化底物。KU-55933使HeLa细胞对电离辐射敏感。在癌细胞中,KU-55933抑制生长因子诱导的Akt的磷酸化作用。KU-55933抑制癌细胞增殖。KU-55933抑制ATM,通过阻断下游TAp63α的激活,提高存活力。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
DU-145 NXHx[oxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1mzc2lEPTB;Mz6yO|M2OiEQvF2= NE\6XHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
HuO-3N1 NEO0cm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTRwMUexOFIh|ryP MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
LAMA-84 NVjrOZZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTRwNUi0OlUh|ryP MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
CAL-72 M{HFXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\NeJY4UUN3ME21MlQ5ODh2IN88US=> NUP0c4RuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
LoVo Moe3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTZwOUOyN|kh|ryP MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
HH M3rrb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnz1TWM2OD16LkK3OlcyKM7:TR?= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
SK-MEL-3 NXHZdmFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRThwMki1O|Uh|ryP M1LIOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
KM12 NGjzPIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPrVXl3UUN3ME25MlIyOTR{IN88US=> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NCI-H1437 NYnpZoRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUX5cWdpUUN3ME25MlgxQTdizszN M1KyRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
NCI-H1838 NGToSZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXBO2tbUUN3ME2xNU4yQDZ3IN88US=> MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
J-RT3-T3-5 NEPPdFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moj3TWM2OD1zMT6yOFE4KM7:TR?= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
GOTO MlXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTFzLk[5PVYh|ryP M4XTS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
LB2241-RCC NYX4RlFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGr6N3VKSzVyPUGxMlcyQDZizszN NEPDWZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
ES7 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;2TWM2OD1zMT63PFgh|ryP MonHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
KP-N-YS NGfqVWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zHOGlEPTB;MUKuOlM2PCEQvF2= M4np[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
CAL-12T NWj4dGZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jyPGlEPTB;MUOuOlE4KM7:TR?= NUPKfWtNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
COLO-684 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17kZ2lEPTB;MUSuNVU3QSEQvF2= MmfjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
DOK Mkf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HtT2lEPTB;MUWuN|MzQSEQvF2= NVrlPIR6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
Hs-578-T NUDCVFZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHH1eVRKSzVyPUG1MlQyQDJizszN MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
D-423MG NYXlSJZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDBTWM2OD1zNT61NlM3KM7:TR?= NVnRbmdXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
DBTRG-05MG M{W3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPhS|lKSzVyPUG1MlYyOTFizszN MnPhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
VM-CUB-1 NUTvbHpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2W0bGlEPTB;MUWuPVg1QSEQvF2= NYLJ[G9bRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
KG-1 NVqyfopuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3nTWM2OD1zNj6wPVk3KM7:TR?= NGfzU5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
8305C MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTF4LkG4PFkh|ryP NVnPeZV5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HuH-7 M1vhV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrIe3NKSzVyPUG2MlI3PzRizszN NYPWXIQ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
LXF-289 M3;lR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnTUY5lUUN3ME2xOk4zPzR5IN88US=> MnvwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
NCI-H1793 M3;hbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTF4LkS3NVIh|ryP MoW1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
ChaGo-K-1 NH[yT5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEKyTo1KSzVyPUG2MlY2PjhizszN NIHX[I49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
GCIY MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTF4Lke5NFUh|ryP NWrIboVRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
SK-MEL-28 NFfnWHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFi4S|FKSzVyPUG3MlA1PzVizszN MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NCI-SNU-1 NWG2XIRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mke5TWM2OD1zNz6xNlY6KM7:TR?= NXX3b3Y6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
CTB-1 M3;SdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzuXnY1UUN3ME2xO{4zOjV7IN88US=> NWjwXGZsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
NCI-H82 NX\oR5RMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTF5LkS1O|Mh|ryP NHzsTpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
HCC2998 MlnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTF5Lk[3N|Mh|ryP M2nIR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
NCI-H2030 MnWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTF6LkG5PVch|ryP NFH1c|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
HuP-T3 M1PFXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTF6LkW4PFgh|ryP MmDEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
697 M4n0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDab5hqUUN3ME2xPU4xOjBzIN88US=> NGjSbHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
MLMA MoTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTTTWM2OD1zOT6wOVU4KM7:TR?= NEHlc3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
HCC70 NIPnT3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;ndIJKSzVyPUG5MlQ5QSEQvF2= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
A704 NFj0T5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHGTWM2OD1zOT64N|A2KM7:TR?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
D-283MED MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfNTWM2OD1{MD61N|M6KM7:TR?= M1vtNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
U031 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTjdpFbUUN3ME2yNU4yPDh7IN88US=> MoewQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
HSC-3 NI\qVW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\NTWM2OD1{MT6xPFM2KM7:TR?= NVnrNZZzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
JVM-3 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTJ{LkWwOkDPxE1? MkDZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
Mewo M2HUcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M133cmlEPTB;MkKuOVA4OyEQvF2= NVXISG06RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
YH-13 NUXGfIdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjkUJFJUUN3ME2yNk42OTJ|IN88US=> Ml\3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
LB1047-RCC MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzMeGVKSzVyPUKyMlU5PzlizszN M3zZVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
HCC2157 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4qzdmlEPTB;MkKuPFA2PCEQvF2= MlPlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
SNU-449 NWTZdlU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLlb3hKSzVyPUKyMlg4PDhizszN NI\2R409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
Ramos-2G6-4C10 M4DZO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HwcWlEPTB;MkKuPVYh|ryP NFuyUG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
CHL-1 M3;RUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTJ|LkeyPVIh|ryP M2LaNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
SK-MEL-30 M3LKeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XJeWlEPTB;MkSuOFY3OiEQvF2= NVW5SWdTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
PANC-08-13 MnfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoP4TWM2OD1{NT6wPVM5KM7:TR?= NVLJcVJlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
QIMR-WIL M1\2bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTJ3LkG4OVgh|ryP NX3BNnRORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
BFTC-905 MnX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvyPGJiUUN3ME2yOU42QTR2IN88US=> NGn5TJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
GI-1 NWTKWphqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\jcotKSzVyPUK1MlcxPTVizszN NUSx[VRORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
MDA-MB-415 NUm4UFdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWCzZlBlUUN3ME2yOk42ODN|IN88US=> MlG4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
GT3TKB MkX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTJ4LkWzOFIh|ryP M3TZVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
DEL M4jtbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzIdW9KSzVyPUK2Mlg{PTZizszN M4TmTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
KOSC-2 NX\GdY4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHjTWM2OD1{Nj65NFc2KM7:TR?= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
RVH-421 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\XPWlEPTB;MkeuNlkzOSEQvF2= M1ywWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
EW-13 NXTlblhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYmzfJVmUUN3ME2yO{41OzB6IN88US=> NWe5[nlkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
639-V NFzteHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrPVW5KSzVyPUK3MlUyOTlizszN NUjkTJBTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
A2780 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;CTWM2OD1{Nz62OFEh|ryP NInhfZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
SW982 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTJ5LkmwOVIh|ryP M3zndVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
SW1710 M1T4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NImweGZKSzVyPUK4MlA6QDFizszN NWPlXWRbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HCC1569 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\idlJKSzVyPUK4MlQ5QTdizszN NGnqUJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
MV-4-11 NWHifWlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHH5RYtKSzVyPUK4MlU4OzVizszN NHLRUZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
BHT-101 MmTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTJ6Lk[1O|Ih|ryP NEfNcHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
Ca9-22 NYrCNm5lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPOcGNKSzVyPUK4MlcyPCEQvF2= NH[4N2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
HAL-01 NYO5T2M6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXztPG9YUUN3ME2yPE44PjF3IN88US=> MkG0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
D-263MG NHPScJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXe2Zo12UUN3ME2yPU4{PDRizszN NGrNflE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
NEC8 NIjiPGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTuTWM2OD1{OT61OVQ5KM7:TR?= NH\GSJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
EKVX MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPQZVJKSzVyPUOxMlU5PDdizszN NY\hdmU3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
EM-2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTNzLk[zNFQh|ryP MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
MFM-223 NFXlbFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3jOHFEUUN3ME2zNU45ODl6IN88US=> NYryR4NuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
SK-PN-DW NU[3R3A3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NID5TXFKSzVyPUOyMlE1ODZizszN NG[wWpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
HuO9 NUfQXFRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTN{LkWyPFIh|ryP NEntVmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
MHH-PREB-1 M1n5TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnGV2xzUUN3ME2zNk43OjN2IN88US=> MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
OVCAR-4 MlfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTN{LkizOlMh|ryP MluyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
NCI-H1648 NGLjZoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFruZnpKSzVyPUOyMlg3PTFizszN Moi1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
MKN1 NYG3dXN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljFTWM2OD1|ND6xNVAyKM7:TR?= M3vNNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
KYSE-450 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTOWHFKSzVyPUO0MlY1PDRizszN MnHuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
ES8 NXjYdollT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPSTWM2OD1|ND64PVc2KM7:TR?= MmjuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
MS-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHoVZhoUUN3ME2zOE46PTV2IN88US=> NHTh[G49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
HOP-92 NXfyeVN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrMTWM2OD1|NT65Nlc4KM7:TR?= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
SKG-IIIa NWPvVFRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;zTGlEPTB;M{[uNlU3OSEQvF2= M1HoRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
TE-11 Mn\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTN4LkWyOFMh|ryP M4fvN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
SK-NEP-1 M3\TZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVr3W2QzUUN3ME2zO{43PzR2IN88US=> MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
DB MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1v0fGlEPTB;M{euPVE5PSEQvF2= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
IA-LM NHOyR5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTN6LkCyN|kh|ryP NHfKVFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
COLO-829 NF[1U4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XIbWlEPTB;M{iuOFE2QSEQvF2= MnfpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
TGBC11TKB NYHLTIZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTN7LkG0NFgh|ryP MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
CAL-51 NVLpdop6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrMZ5FvUUN3ME20NE4xPjF{IN88US=> MkTNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
NCI-H2228 M{nhR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3p[FdGUUN3ME20NE4{PjZ{IN88US=> NWLycG17RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
C32 MlGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\TNnB4UUN3ME20NE41ODJ2IN88US=> NV:ycVRkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
KU-19-19 NGLYXmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTRyLke2PFMh|ryP MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
KNS-62 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\BRWlEPTB;NECuPFM5OSEQvF2= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
FADU NWjZXplqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTRzLkK1NFIh|ryP NEDXeWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
CAL-33 MkDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7GTY5KUUN3ME20Nk43PzR7IN88US=> M1PTcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
CHP-134 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTR{Lki0PVYh|ryP MkTwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
HDLM-2 MoHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljiTWM2OD12Mj65NFg1KM7:TR?= NXnzbZlVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
NBsusSR NHnnRo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTR|LkC3NlUh|ryP MkHHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
SW954 MlXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLjUGZwUUN3ME20N{4yODV|IN88US=> NFzzTG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
HCC1806 M16wVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYntPHlQUUN3ME20N{41OTFizszN MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
VMRC-RCZ M2PNWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDKTWM2OD12Mz60OVg3KM7:TR?= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
A549 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTR|LkmzNUDPxE1? Mn\EQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
NKM-1 MkHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTR|Lkm1OVgh|ryP NEDQOHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
DMS-273 Mnj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;1XHRGUUN3ME20OE44PTZ5IN88US=> NFvs[Vg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
TYK-nu NFTPO|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfHdVVKSzVyPUS1MlEzOzRizszN MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
KALS-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\x[nBKSzVyPUS1MlE1PiEQvF2= M4jGU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
A101D M{fMPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXNTWM2OD12NT60OFU3KM7:TR?= NGrSSZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
G-361 NFu4NWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1G3NmlEPTB;NE[uNlE{QCEQvF2= M3fLe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
KARPAS-299 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlq5TWM2OD12Nj6zOVE3KM7:TR?= MmrWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
RS4-11 NYPlfnJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILMcGRKSzVyPUS2MlU1OiEQvF2= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
HT-1376 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYmyTopMUUN3ME20Ok44PDJ4IN88US=> M3rQOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
SK-N-AS MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LnWmlEPTB;NE[uO|gzOiEQvF2= NIHCcoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
MG-63 NWLTcmpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTR4LkmwN|Yh|ryP NVPWdXFwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
EPLC-272H M2PhZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jCVGlEPTB;NE[uPVUxOyEQvF2= M1vwXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
BALL-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDqTWM2OD12Nz64N|Ih|ryP NGTOR4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
LCLC-97TM1 M3PyR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTR6LkKwNkDPxE1? NVLTZYZoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HO-1-N-1 MnTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHuVIptUUN3ME20PE46Pjd4IN88US=> MlTMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
MFE-280 NFj2O|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\JfWhKSzVyPUS5MlQ3OTdizszN MoPRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
NCI-H526 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTR7LkixOlMh|ryP NYfveJl[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
D-566MG NY\5Uo1WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{OwNmlEPTB;NEmuPVA6PiEQvF2= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
BB30-HNC MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnnd44yUUN3ME20PU46PDl6IN88US=> NYLuN4VmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
SK-N-DZ NVW5ZmZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzGfWlUUUN3ME21NE4xPDhzIN88US=> NGDZSXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
HepG2  M1T5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWOxNOKh|ryP MV2yOEBp NYjiWWV{[myxY3vzJHNENUmLSUOtbY5lfWOnZDDTJJBp[XOnIHHydoV{fA>? NYfS[oU{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1NlcyOjNpPkK1OVI4OTJ|PD;hQi=>
HepG2  MV\GeY5kfGmxbjDBd5NigQ>? NH7F[2YyOMLizszN NY\VUZdYOjRiaB?= M3;rVpN2eHC{ZYPz[ZMhfGinIIDoc5NxcG:{eXzheIlwdnNib3[gRXROKG:wIGPldlE6QDFuIFPob|Ehd25iU3XyN|Q2NCCFaHuyJI9vKFSqck[4MEBidmRiQ3TrNkBwdiCWeYKxOUBqdmS3Y3XkJIJ6KFOFLVnJTVM> NISwOnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUWyO|EzOyd-MkW1NlcyOjN:L3G+
KATO III  NW\TSHJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPNe4czNjVxNT:3MlUh|ryP NF;1T4VFVVOR MV3lcohidmOnczD0bIUhfG:6aXPpeJkhd2Zib3zhdIFzcWJ? NVTiXFFURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4OFE4OThpPkK0PFQyPzF6PD;hQi=>
hTCEpi M36zT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX:2SFBLOTBizszN NVPaTlRzTE2VTx?= MUTwdoV3\W62czD0bIUh[3m2b4DheIhq[yCnZn\lZ5Qhd2ZiSGPWMVE> MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN5MEizOUc,OjR|N{C4N|U9N2F-
MCF10A MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\NSphlOTBizszN M4DYdVI1KGh? Moe1SG1UVw>? M1TVcJBwfGWwdHnheIV{KHSqZTDjfZRwfG:6aXPpeJkhd2ZiR1G= M1jF[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUWwOVk2Lz5{NEG1NFU6PTxxYU6=
HL-60  MUXGeY5kfGmxbjDBd5NigQ>? NF\lU|kyOCEQvF2= NHjicXExNjViaB?= MXrEUXNQ NELqS45z\WS3Y3XzJJBpd3OyaH;yfYxifGmxbjDv[kBEcGt{wrC= M4e2SVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUO0OFEyLz5{M{mzOFQyOTxxYU6=
MCF-7 MmPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXmx[olKOS1zMEFOwG0> MVOyOEBp M2rFb2ZDWw>? MXPpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9v M1rHOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MUi1N|Q4Lz5{M{G4OVM1PzxxYU6=
HeLa  NY\1Vm1NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUixMVExOM7:TR?= MXWyOEBp Mn;ESmJU NFzSeXFqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:w NH\QVmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G4OVM1Pyd-MkOxPFU{PDd:L3G+
SH-SY5Y MVXGeY5kfGmxbjDBd5NigQ>? M1[1[lExyqEQvF5CpC=> Mn\ENlQhcA>? MXjpcohq[mm2czDjcIlweXWrbn;sMYlv\HWlZXSgdIhwe3Cqb4L5cIF1cW:wIH;mJJA2Ow>? M4L1UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NkK3Nlk1Lz5{Mk[yO|I6PDxxYU6=
IMR-32 NXnKcWpSTnWwY4Tpc44hSXO|YYm= NXzncm01OTEEoN88UeKh MXmyOEBp NH7MUnFqdmirYnn0d{BkdGmxcYXpco9tNWmwZIXj[YQheGixc4Doc5J6dGG2aX;uJI9nKHB3Mx?= NV34NJdyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2NlczQTRpPkKyOlI4Ojl2PD;hQi=>
A549 NXvnWVdqTnWwY4Tpc44hSXO|YYm= MXOxNOKh|ryPwrC= MoP2NUBp NVXHeXFVe3WycILld5NmeyCQYX7vMWNwNWmwZIXj[YQheDV|IHHjZ5VufWyjdHnvci=> MlXDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3NUmzNlEoRjJ{NUW5N|IyRC:jPh?=
T47D  MlLUSpVv[3Srb36gRZN{[Xl? NX:yNoNlOjEEoH3N NH7peJQzPCCq MVfEUXNQ M2mxXZBz\X[nboTzJGlTNWmwZIXj[YQh\GWpcnHkZZRqd25ib3[gTe67Ss7z M2rpbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUS0PFA2Lz5{MUG0OFgxPTxxYU6=
A29 MEF MmiySpVv[3Srb36gRZN{[Xl? NXvrV4g3OTEEoN88UeKh NYXK[|lWOWh? NXuxXHZE[myxY3vzxsB1cGVicHjvd5Bpd3K7bHH0bY9vKG:oIFHreEBifCCVZYK0O|PDqA>? NXXVTmJTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOVM4QDFpPkKwNFU{PzhzPD;hQi=>
MDA-MB-453  MkPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTQOU01OCEQvF2= NF73fHY4OiCq MWXJR|UxKG:oIEGwJO69VQ>? NGGycII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEC1N|c5OSd-MkCwOVM4QDF:L3G+
PC-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TrdlUuPDBizszN MmDvO|IhcA>? MV;JR|UxKG:oIEGwJO69VQ>? NGq3b3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEC1N|c5OSd-MkCwOVM4QDF:L3G+
U2OS NWDGZZJHTnWwY4Tpc44h[XO|YYm= MnL0TY5pcWKrdHnvckBw\iCDVF2gbY4hcHWvYX6gWVJQWyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJA2OyCyaH;zdIhwenmuYYTpc44h[XRiU3XyNVUhemW|aXT1[UwhUUN3MDC9JFAvOjVizszNMi=> NWr4UldyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2N|I6PjVpPkK2OlMzQTZ3PD;hQi=>
MCF7 MVnGeY5kfGmxbjDhd5NigQ>? NGC0O3AyKGi{ Mon1TY5pcWKrdHnvckBw\iCDVF2gb4lv[XOnIHnuJIh2dWGwIF3DSlch[2WubIOgZYZ1\XJiMTDodkBjgSCrbX31co9ndHWxcnXzZ4Vv[2ViYYPzZZktKEmFNUCgQUAxNjNizszNMi=> NFfNZWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[zNlk3PSd-Mk[2N|I6PjV:L3G+
BJ MUTGeY5kfGmxbjDhd5NigQ>? NYnJO5FxOTBidV2= NEexTYMyOCCmYYnz MU\TeZBxemW|c3nvckBw\iC|ZX7ld4NmdmOnIHnuJIh2dWGwIFLKJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGOnbHygcpVu[mW{IHH0JFExKHWPIHHmeIVzKDFyIHThfZMh[nlic3Xu[ZNk\W6lZTDy[ZZmenOjbDDhd5NigQ>? M{XjSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4N{[3NFg2Lz5zNke2O|A5PTxxYU6=
BJ MmXHSpVv[3Srb36gZZN{[Xl? NFXnfooyOCC3TR?= M4f6eFExKGSjeYO= NHzFc5NKdmirYnn0bY9vKG:oIHH0ZZhq[SC2ZXzhcodq\WO2YYPpZU1ufXSjdHXkJIlvKGi3bXHuJGJLKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHPlcIwhdnWvYnXyJIF1KDFyIIXNJIFnfGW{IEGwJIRigXNiYomgd4Vv\XOlZX7j[UBz\X[ncoPhcEBie3OjeR?= M1z5bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4N{[3NFg2Lz5zNke2O|A5PTxxYU6=
MCF7 MoTpSpVv[3Srb36gZZN{[Xl? NVXwR|M3OTBidV2= NH6yeZgyOCCvaX7z NHHJOFdU\W6|aYTpfoF1cW:wIH;mJIlv\nKjcnXkMYlv\HWlZXSgSG5CKGSjbXHn[UBqdiCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBkd2yxbomg[o9zdWG2aX;uJIF1KDFyIIXNJJBz\XS{ZXH0[YQh\m:{IEGwJI1qdnNiZn;scI94\WRiYomgbZJz[WSrYYTpc44h\m:{IESgbJJ{KG2nYYP1doVlKGGodHXyJFExKGSjeYOgZpkh[3K7c4ThcEB3cW:uZYSgd5RicW6rbnegZY5idHm|aYO= NEfqbYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[zNlk3PSd-Mk[2N|I6PjV:L3G+
SK-N-MC MnHpdWhVWyCjc4PhfS=> NX\UZ3ZzeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGPLMW4uVUNiY3XscJM> NGX2WXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT(Ser473) / p-AKT(Thr308); 

PubMed: 22739265     


Cells were serum-starved for 6 h and treated with KU-55933 (10 µmol/L) for 1 h before treatment with insulin (100 nmol/L) for 45 min. Cells were lysed, and cell lysates were subjected to SDS-PAGE and Western blotting for the detection of phospho-Akt at Se䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖

PARP / Cleaved PARP / Caspase-3 / Cleaved caspase-3 ; 

PubMed: 22739265     


ATM inhibition by KU-55933 induces apoptosis in differentiated but not undifferentiated SH-SY5Y cells. Cells were starved for 6 h in serum-free medium. KU-55933 (10 µmol/L) was added 1 h before insulin (100 nmol/L) treatment. After 3 h of insulin stimulat䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤

ATM-S1981 / ATM / p-p53(S15) / p53 ; 

PubMed: 20639198     


Antioxidant and ATM inhibitors blocked phosphorylation of ATM-S1981, Akt-S473, and p53-S15 as stimulated by H2O2 exposure. Cells were treated with 100 μm H2O2 for 30 min in the absence or presence of KU-55933. Whole cell lysates were subjected to Western 䲧疝Ỵ疞㧀疜膉痘 瘿뾠ՂᾰƌՂĀ 㺣痖

p21 / p27 / p53 ; 

PubMed: 20177072     


HMGE cells were incubated for the indicated times with 1 μm KU-55933 or DMSO. Total protein extracts were analyzed by Western blotting for p21WAF1/CIP1, p27KIP1, p53, or β-actin.

22739265 20639198 20177072
Immunofluorescence
p-S824 KAP1 / ZEBRA ; 

PubMed: 28249048     


HH514-16 cells were treated with NaB (upper panel) or NaB plus KU-55933 (1μM; middle panel) or NaB plus Torin1 (0.5μM; lower panel) for 24 hours and stained with anti-phospho KAP1 (S824) plus anti-ZEBRA antibodies and visualized at 1000X magnification.

28249048
体内研究 KU-55933抑制ATM依赖的STAT3激活,通过上调DR5表达增强TRAIL调节的凋亡,抑制STAT3 和NF-κB都和下调cFLIP有关,伴随着凋亡水平上升。ATM抑制剂KU-55933 影响TRAIL调节的凋亡的效果比JAK2抑制剂AG490或STAT3β过量表达都高。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

纯化的酶实验:

通过免疫沉淀反应从HeLa核蛋白萃取中获得用于体外研究的ATM,在反应buffer中,把兔多克隆抗血清加到ATM羧基端第400个氨基酸处,buffer包含25 mM HEPES (pH为7.4), 2 mM MgCl2, 250 mM KCl, 500 μM EDTA, 100 μM Na3VO4, 10% v/v 甘油, 及0.1% v/v Igepal。和蛋白A凝胶温育1小时,然后进行离心作用,从核蛋白中分离ATM抗体复合物。在96孔板中,包含ATM的凝胶珠和1 μg 底物GST-p53N66 (p53的氮端第66位氨基酸与GST融合)在ATM实验buffer中37oC下温育,buffer包括25 mM HEPES (pH 为7.4), 75 mM NaCl, 3 mM MgCl2, 2 mM MnCl2, 50 μM Na3VO4, 500 μM DTT, 及5% v/v甘油。震荡10分钟后,加入ATP,最终浓度为50 μM,在37oC反应持续1小时。按250×g转速4oC下离心10分钟,除去ATM凝胶珠,上清液转移到96孔板上,在室温下温育1.5小时。然后用PBS冲洗,烘干,加入p-p53(Ser15)抗体用于ELISA分析。使用增强的化学发光溶液产生信号和化学发光。
细胞实验:

[1]

- 合并
  • Cell lines: U2OS细胞
  • Concentrations: 10 μM
  • Incubation Time: 2小时
  • Method:

    U2OS细胞经过电离辐射(3, 5, 或15 Gy) 或者UV处理(5或50 J/m2),通过p-p53(Ser15)和p53 的Western blot分析而测定ATM反应。在不同时间点获得细胞萃取物,SDS-PAGE分离蛋白,加入p-p53(Ser15)抗体,ATM增多。加入p53抗体观察到p53随着时间变化趋于稳定。为了测定KU-55933的IC50值,使用p-p53(Ser15)抗体检测KU-55933抑制ATM的效果。KU-55933加到细胞中,预温育1小时,然后进行电离辐射。在体外,使用扫描密度测定法测定IC50值。


    (Only for Reference)
动物实验:

[3]

- 合并
  • Animal Models: 携带LU1205细胞的BALB/c nu/nu鼠
  • Dosages: 10 μM
  • Administration: --
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 33 mg/mL (83.44 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5%DMSO+40%PEG300+5%Tween80+50%ddH2O
3.95 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 395.49
化学式

C21H17NO3S2

CAS号 587871-26-9
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

ATM/ATR Signaling Pathway Map

ATM/ATR Inhibitors with Unique Features

相关ATM/ATR产品

Tags: 购买KU-55933 (ATM Kinase Inhibitor) | KU-55933 (ATM Kinase Inhibitor)供应商 | 采购KU-55933 (ATM Kinase Inhibitor) | KU-55933 (ATM Kinase Inhibitor)价格 | KU-55933 (ATM Kinase Inhibitor)生产 | 订购KU-55933 (ATM Kinase Inhibitor) | KU-55933 (ATM Kinase Inhibitor)代理商
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID