KU-55933 (ATM Kinase Inhibitor)

For research use only. Not for use in humans.

目录号：S1092

KU-55933 (ATM Kinase Inhibitor) Chemical Structure

CAS No. 587871-26-9

KU-55933 (ATM Kinase Inhibitor)是一种有效的，特异性ATM抑制剂，在无细胞试验中IC50/K_i为12.9 nM/2.2 nM，与DNA-PK， PI3K/PI4K， ATR和mTOR相比，对ATM具有高度选择性。KU‑55933 (ATM Kinase Inhibitor)可抑制 autophagy‑initiating kinase ULK1 的激活从而导致自噬的显著减少。

规格

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库存

购买数量

10mM (1mL in DMSO)	RMB 917.23	现货
5mg	RMB 571.66	现货
10mg	RMB 975.88	现货
50mg	RMB 3032.31	现货
200mg	RMB 7755.93	现货
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客户使用Selleck生产的KU-55933 (ATM Kinase Inhibitor)发表文献250篇：

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PubMed: ( click the link to review the publication )

Proteomes, 2014, 2(3):451-467

PubMed: 28250390 ( click the link to review the publication )

PLoS One, 2014, 9(6):e98891

PubMed: 24902048 ( click the link to review the publication )

Nucleic Acids Res, 2013, 41(22):10157-69

PubMed: 24021630 ( click the link to review the publication )

Sci Signal, 2013, 6(259):ra5

PubMed: 23354688 ( click the link to review the publication )

FEBS Lett, 2013, 587(21):3437-43

PubMed: 24021642 ( click the link to review the publication )

PLoS One, 2013, 9(1):e84899

PubMed: 24454762 ( click the link to review the publication )

PLoS One, 2013, 8(11):e80313

PubMed: 24282534 ( click the link to review the publication )

J Gen Virol, 2013, 94(Pt 12):2664-2669

PubMed: 24045107 ( click the link to review the publication )
Cell Cycle, 2013, 12(7):1105-18

PubMed: 23462183 ( click the link to review the publication )

Autophagy, 2012, 8(2):236-51

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J Immunol, 2012, 188(5):2266-75

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产品安全说明书

ATM/ATR抑制剂选择性比较

生物活性

产品描述

靶点

ATM ^[1]
(Cell-free assay)

12.9 nM

体外研究

KU-55933是有效的特定ATM抑制剂，IC50为13 nM，K_i值为2.2 nM。KU-55933也抑制DNA-PK和PI3K，IC50分别为2.5和16.6 μM。KU-55933也抑制mTOR活性，IC50为9.3 μM。KU-55933有效作用于ATM依赖的磷酸化作用。KU-55933抑制ATM依赖的磷酸化作用，存在剂量依赖性，IC50为300 nM。小于30 μM时，KU-58050不能抑制p53的ATM-依赖性磷酸化作用（位点为第15位丝氨酸）。在UV-诱导的H2AX（位点为第139位丝氨酸）, NBS1（位点为第343为丝氨酸）, CHK1（位点为第345位丝氨酸）,及SMC1（位点为第966位丝氨酸）中，加入KU-55933没有明显作用效果。紫外处理时，KU-55933切除由电离辐射诱导的ATM磷酸化底物。KU-55933使HeLa细胞对电离辐射敏感。在癌细胞中，KU-55933抑制生长因子诱导的Akt的磷酸化作用。KU-55933抑制癌细胞增殖。KU-55933抑制ATM，通过阻断下游TAp63α的激活，提高存活力。^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
DU-145	NInwdFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NX7sVGR[UUN3ME2zMlI4OzV{IN88US=>	NEPjT5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
HuO-3N1	Mlj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2fXWmlEPTB;ND6xO\|E1OiEQvF2=	MmTkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
LAMA-84	NYPIfZBLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGriUJNKSzVyPUSuOVg1PjVizszN	Mm\GQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
CAL-72	NXvVUVZiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1K5bmlEPTB;NT60PFA5PCEQvF2=	NHXCSpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
LoVo	NXu0OYlZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{fKR2lEPTB;Nj65N\|I{QSEQvF2=	NVm1NWQ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HH	Mnv3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{j3Z2lEPTB;OD6yO\|Y4OSEQvF2=	NH3kU2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
SK-MEL-3	NULMdmtuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHizPI1KSzVyPUiuNlg2PzVizszN	NWe1R2M4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
KM12	MlfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2fMd2lEPTB;OT6yNVE1OiEQvF2=	NWPWe5dDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
NCI-H1437	MnjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NE\ueodKSzVyPUmuPFA6PyEQvF2=	NFnMSoU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
NCI-H1838	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NULNPIJNUUN3ME2xNU4yQDZ3IN88US=>	M3TobVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
J-RT3-T3-5	NFXNSZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVfYTFNmUUN3ME2xNU4zPDF5IN88US=>	Mn\IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
GOTO	M2Ozdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{TRd2lEPTB;MUGuOlk6PiEQvF2=	MnvuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
LB2241-RCC	M3OyRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkfBTWM2OD1zMT63NVg3KM7:TR?=	M4P2fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
ES7	NE\OU2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlLpTWM2OD1zMT63PFgh\|ryP	M4nDbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
KP-N-YS	MoOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoqzTWM2OD1zMj62N\|U1KM7:TR?=	M1SzclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
CAL-12T	NHvObHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnThTWM2OD1zMz62NVch\|ryP	Mnf6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
COLO-684	M3fKdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MV;JR\|UxRTF2LkG1Olkh\|ryP	Ml75QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
DOK	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWPJR\|UxRTF3LkOzNlkh\|ryP	MlXrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
Hs-578-T	MofJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoP4TWM2OD1zNT60NVgzKM7:TR?=	MlnYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
D-423MG	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnHUTWM2OD1zNT61NlM3KM7:TR?=	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
DBTRG-05MG	NXz6SlhJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NX\zcmZvUUN3ME2xOU43OTFzIN88US=>	NV\Mfo1kRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
VM-CUB-1	NYniR3pjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWfIPZl2UUN3ME2xOU46QDR7IN88US=>	NHXHWoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
KG-1	M{HkUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmjkTWM2OD1zNj6wPVk3KM7:TR?=	NXvSW\|VCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
8305C	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUnJR\|UxRTF4LkG4PFkh\|ryP	MkPQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
HuH-7	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mn\mTWM2OD1zNj6yOlc1KM7:TR?=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
LXF-289	NWTGfXVjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWDIe\|JpUUN3ME2xOk4zPzR5IN88US=>	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NCI-H1793	Ml;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXjjbYFMUUN3ME2xOk41PzF{IN88US=>	Mmi3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
ChaGo-K-1	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFT4WINKSzVyPUG2MlY2PjhizszN	NX7IR\|c5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
GCIY	NWS0T\|BJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYLJR\|UxRTF4Lke5NFUh\|ryP	M1jLclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
SK-MEL-28	MoDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWLtfGlLUUN3ME2xO{4xPDd3IN88US=>	NWC4b3FMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
NCI-SNU-1	NUnFdJMxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXvJR\|UxRTF5LkGyOlkh\|ryP	Mni1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
CTB-1	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUXJR\|UxRTF5LkKyOVkh\|ryP	MkXSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
NCI-H82	NWi0eodST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWrJR\|UxRTF5LkS1O\|Mh\|ryP	M{DKb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
HCC2998	NYG3OWRtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYW0VmhqUUN3ME2xO{43PzN\|IN88US=>	NGr5eJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
NCI-H2030	NFTie29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1faZ2lEPTB;MUiuNVk6PyEQvF2=	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
HuP-T3	NWKwbmppT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXXJR\|UxRTF6LkW4PFgh\|ryP	NGPsc5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
697	NWrNSIdnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlPzTWM2OD1zOT6wNlAyKM7:TR?=	MnXUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
MLMA	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{nGemlEPTB;MUmuNFU2PyEQvF2=	M3LGRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
HCC70	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYHoOXk{UUN3ME2xPU41QDlizszN	M2DOTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
A704	NWPJN2ZGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmfSTWM2OD1zOT64N\|A2KM7:TR?=	NUXIT41[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
D-283MED	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmrWTWM2OD1{MD61N\|M6KM7:TR?=	M2O0flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
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TE-11	Mo\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFPI[nlKSzVyPUO2MlUzPDNizszN	M{XUcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
SK-NEP-1	NX\zWmxOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NH7kWXRKSzVyPUO3MlY4PDRizszN	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
DB	NH;XcY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXjJR\|UxRTN5LkmxPFUh\|ryP	NIPPWnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
IA-LM	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFfZO\|JKSzVyPUO4MlAzOzlizszN	M3q5bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
COLO-829	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWjJR\|UxRTN6LkSxOVkh\|ryP	MnXKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
TGBC11TKB	NIjBUHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3TCdWlEPTB;M{muNVQxQCEQvF2=	NWC3VYZ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
CAL-51	M1zkRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWrJR\|UxRTRyLkC2NVIh\|ryP	MmDEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
NCI-H2228	M3fp[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHXWVo1KSzVyPUSwMlM3PjJizszN	NFKyW5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
C32	M{fkdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHLaRlJKSzVyPUSwMlQxOjRizszN	MnHwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
KU-19-19	NGrO[WVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M16xbGlEPTB;NECuO\|Y5OyEQvF2=	MoHOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
KNS-62	Mkn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUnJR\|UxRTRyLkizPFEh\|ryP	NWLLbHFvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
FADU	Mnz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1TWemlEPTB;NEGuNlUxOiEQvF2=	NYf6e5NWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
CAL-33	M1TLU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MV3JR\|UxRTR{Lk[3OFkh\|ryP	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
CHP-134	MlS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXfoWGM3UUN3ME20Nk45PDl4IN88US=>	MnnuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
HDLM-2	NYHyeWN1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYno[nVDUUN3ME20Nk46ODh2IN88US=>	NUjFTlR5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
NBsusSR	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1rHS2lEPTB;NEOuNFczPSEQvF2=	NWi4WlBSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
SW954	M2S5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1vRbWlEPTB;NEOuNVA2OyEQvF2=	NXzodmZHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HCC1806	NGTLXHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIXIZ3FKSzVyPUSzMlQyOSEQvF2=	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
VMRC-RCZ	MkLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1Pm[GlEPTB;NEOuOFU5PiEQvF2=	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
A549	MmL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1Hi[GlEPTB;NEOuPVMyKM7:TR?=	M2XG[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
NKM-1	NF\FSHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWnzeWtEUUN3ME20N{46PTV6IN88US=>	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
DMS-273	NVvqRm1tT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHzwWnFKSzVyPUS0Mlc2PjdizszN	NI[2[WE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
TYK-nu	NYXL[GJMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFT0dIZKSzVyPUS1MlEzOzRizszN	NUnwW4xTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
KALS-1	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnrUTWM2OD12NT6xOFYh\|ryP	NGTuemU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
A101D	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1X2WmlEPTB;NEWuOFQ2PiEQvF2=	M2fyfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
G-361	M4TKRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkSzTWM2OD12Nj6yNVM5KM7:TR?=	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
KARPAS-299	NWHW[JRHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NX:yU4F4UUN3ME20Ok4{PTF4IN88US=>	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
RS4-11	M1Tjemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYLJR\|UxRTR4LkW0NkDPxE1?	NGnGOHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
HT-1376	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFHL[mRKSzVyPUS2Mlc1OjZizszN	NY\veWQ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
SK-N-AS	MlmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NH\HbIJKSzVyPUS2Mlc5OjJizszN	NEezXo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
MG-63	NHi5TIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWXJR\|UxRTR4LkmwN\|Yh\|ryP	MnLMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
EPLC-272H	NYL5WGY3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGHYRmxKSzVyPUS2Mlk2ODNizszN	MknvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
BALL-1	Mn;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NV\hSJhqUUN3ME20O{45OzJizszN	NV7JRmpRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
LCLC-97TM1	NHHifY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUjJR\|UxRTR6LkKwNkDPxE1?	NVrZXnVIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HO-1-N-1	NIXTPZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{DCWWlEPTB;NEiuPVY4PiEQvF2=	MkfFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
MFE-280	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmL5TWM2OD12OT60OlE4KM7:TR?=	MnnZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
NCI-H526	Mm\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF3SU3FKSzVyPUS5MlgyPjNizszN	NWLQV2U1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
D-566MG	MmrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFzpXmxKSzVyPUS5MlkxQTZizszN	NIG4[Hc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
BB30-HNC	M3;oTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M160emlEPTB;NEmuPVQ6QCEQvF2=	NFTDOHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
SK-N-DZ	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnnJTWM2OD13MD6wOFgyKM7:TR?=	NEHVdlE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
HepG2	NY\UPXhyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHSzbJkyOMLizszN	Mn;6NlQhcA>?		M2P5doJtd2OtczDTR{1KUUl\|LXnu[JVk\WRiUzDwbIF{\SCjcoLld5Q>	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTV{N{GyN{c,OjV3MkexNlM9N2F-
HepG2	NXPBc\|RkTnWwY4Tpc44hSXO\|YYm=	M{Lwb\|ExyqEQvF2=	Mor1NlQhcA>?		MlvSd5VxeHKnc4Pld{B1cGVicHjvd5Bpd3K7bHH0bY9veyCxZjDBWG0hd25iU3XyNVk5OSxiQ3jrNUBwdiCVZYKzOFUtKEOqa{Kgc44hXGi{NkisJIFv\CCFZHuyJI9vKFS7ckG1JIlv\HWlZXSgZpkhW0NvSVnJNy=>	MnWxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MkexNlMoRjJ3NUK3NVI{RC:jPh?=
KATO III	NFLse4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWTp[ItVOi53L{WvO{42KM7:TR?=		NETWUZdFVVOR	MlTR[Y5p[W6lZYOgeIhmKHSxeHnjbZR6KG:oIH;sZZBiemmk	M3nuVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OESxO\|E5Lz5{NEi0NVcyQDxxYU6=
hTCEpi	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4PBNFExKM7:TR?=		M322cGROW09?	NWrr[FM1eHKndnXueJMhfGinIHP5eI9x[XSqaXOg[YZn\WO2IH;mJGhUXi1z	MoDHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|N{C4N\|UoRjJ2M{ewPFM2RC:jPh?=
MCF10A	MoCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3XEWVExKM7:TR?=	MVGyOEBp	M4rUVGROW09?	MWnwc5RmdnSrYYTld{B1cGViY4n0c5RwgGmlaYT5JI9nKEeD	NFPCepk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEG1NFU6PSd-MkSxOVA2QTV:L3G+
HL-60	MV7GeY5kfGmxbjDBd5NigQ>?	MkjtNVAh\|ryP	MUOwMlUhcA>?	MnTXSG1UVw>?	M3rlVJJm\HWlZYOgdIhwe3Cqb4L5cIF1cW:wIH;mJGNpczMEoB?=	NWrPW297RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5N\|Q1OTFpPkKzPVM1PDFzPD;hQi=>
MCF-7	NUjDUI9xT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3rjXlEuOTByzszN	NY\JSZVNOjRiaB?=	M4HrVGZDWw>?	NUnyPYdwcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbh?=	NUeyUopJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxPFU{PDdpPkKzNVg2OzR5PD;hQi=>
HeLa	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2XhTFEuOTByzszN	NGHE[lAzPCCq	M2rTc2ZDWw>?	NV:4eGtFcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbh?=	M3TWRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MUi1N\|Q4Lz5{M{G4OVM1PzxxYU6=
SH-SY5Y	MlnsSpVv[3Srb36gRZN{[Xl?	NUfzRVA1OTEEoN88UeKh	NXLMTZE1OjRiaB?=		NIHVc2hqdmirYnn0d{BkdGmxcYXpco9tNWmwZIXj[YQheGixc4Doc5J6dGG2aX;uJI9nKHB3Mx?=	NV;Ne5hqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2NlczQTRpPkKyOlI4Ojl2PD;hQi=>
IMR-32	NVjOTWwzTnWwY4Tpc44hSXO\|YYm=	NE\tNFYyOMLizszNxsA>	MmL0NlQhcA>?		MUDpcohq[mm2czDjcIlweXWrbn;sMYlv\HWlZXSgdIhwe3Cqb4L5cIF1cW:wIH;mJJA2Ow>?	NUjaOVd7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2NlczQTRpPkKyOlI4Ojl2PD;hQi=>
A549	M1rDPGZ2dmO2aX;uJGF{e2G7	MkTDNVDDqM7:TdMg	M2D0VFEhcA>?		NVz4OVB6e3WycILld5NmeyCQYX7vMWNwNWmwZIXj[YQheDV\|IHHjZ5VufWyjdHnvci=>	NX;LTXpLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1OVk{OjFpPkKyOVU6OzJzPD;hQi=>
T47D	NGTLNoxHfW6ldHnvckBCe3OjeR?=	M3L2Z\|IxyqCvTR?=	NF;ocHAzPCCq	MonVSG1UVw>?	Mm\NdJJmfmWwdIOgTXIucW6mdXPl[EBl\We{YXTheIlwdiCxZjDJ{tpD\|rF?	NF;RUYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUG0OFgxPSd-MkGxOFQ5ODV:L3G+
A29 MEF	M4r1eWZ2dmO2aX;uJGF{e2G7	NXHOOZNOOTEEoN88UeKh	NXrIXW4zOWh?		NEj5UnljdG:la4RCpJRp\SCyaH;zdIhwenmuYYTpc44hd2ZiQXv0JIF1KFOnckS3N:Kh	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB3M{e4NUc,OjByNUO3PFE9N2F-
MDA-MB-453	NGjBU25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mni2OU01OCEQvF2=	NWjFU\|k5PzJiaB?=		MYLJR\|UxKG:oIEGwJO69VQ>?	M1PRfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMEWzO\|gyLz5{MEC1N\|c5OTxxYU6=
PC-3	M1u2Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV:1MVQxKM7:TR?=	NXXxSYhjPzJiaB?=		MmfKTWM2OCCxZjCxNEDPxE1?	NU\BOFd[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOVM4QDFpPkKwNFU{PzhzPD;hQi=>
U2OS	NIn5b4RHfW6ldHnvckBie3OjeR?=				MnX2TY5pcWKrdHnvckBw\iCDVF2gbY4hcHWvYX6gWVJQWyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJA2OyCyaH;zdIhwenmuYYTpc44h[XRiU3XyNVUhemW\|aXT1[UwhUUN3MDC9JFAvOjVizszNMi=>	NGi0PXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[zNlk3PSd-Mk[2N\|I6PjV:L3G+
MCF7	MlfXSpVv[3Srb36gZZN{[Xl?		M1PSR\|EhcHJ?		NVjSTGlNUW6qaXLpeIlwdiCxZjDBWG0hc2mwYYPlJIlvKGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgNUBpeiCkeTDpcY12dm:obIXvdoV{[2WwY3WgZZN{[XluIFnDOVAhRSByLkOg{txONg>?	NXjsS21pRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2N\|I6PjVpPkK2OlMzQTZ3PD;hQi=>
BJ	MVTGeY5kfGmxbjDhd5NigQ>?	NW\vS2hyOTBidV2=	MmC1NVAh\GG7cx?=		NXvhPZRNW3WycILld5Nqd25ib3[gd4Vv\XOlZX7j[UBqdiCqdX3hckBDUiClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDj[YxtKG63bXLldkBifCBzMDD1UUBi\nSncjCxNEBl[Xm\|IHL5JJNmdmW\|Y3XuZ4UhemW4ZYLzZYwh[XO\|YYm=	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd4N{C4OUc,OTZ5NkewPFU9N2F-
BJ	MXTGeY5kfGmxbjDhd5NigQ>?	MnLTNVAhfU1?	M3q4NlExKGSjeYO=		NWX0bINqUW6qaXLpeIlwdiCxZjDheIF5cWFidHXsZY5ocWWldHHzbYEudXW2YYTl[EBqdiCqdX3hckBDUiClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDj[YxtKG63bXLldkBifCBzMDD1UUBi\nSncjCxNEBl[Xm\|IHL5JJNmdmW\|Y3XuZ4UhemW4ZYLzZYwh[XO\|YYm=	NWW0R\|VjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[3OlcxQDVpPkG2O\|Y4ODh3PD;hQi=>
MCF7	MWHGeY5kfGmxbjDhd5NigQ>?	M4HibVExKHWP	MUmxNEBucW6\|		M4LWc3NmdnOrdHn6ZZRqd25ib3[gbY5nemG{ZXStbY5lfWOnZDDEUmEh\GGvYXflJIlvKGi3bXHuJG1ETjdiY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINwdG:weTDmc5Ju[XSrb36gZZQhOTBidV2gdJJmfHKnYYTl[EBnd3JiMUCgcYlveyCob3zsc5dm\CCkeTDpdpJi\GmjdHnvckBnd3JiNDDodpMhdWWjc4Xy[YQh[W[2ZYKgNVAh\GG7czDifUBkenm\|dHHsJJZqd2yndDDzeIFqdmmwZzDhcoFtgXOrcx?=	M12wUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkOyPVY2Lz5{Nk[zNlk3PTxxYU6=
SK-N-MC	NVnHfIJVeUiWUzDhd5NigQ>?				MVrxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?=	MoCzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-AKT(Ser473) / p-AKT(Thr308); PubMed: 22739265 Chin J Cancer Cells were serum-starved for 6 h and treated with KU-55933 (10 µmol/L) for 1 h before treatment with insulin (100 nmol/L) for 45 min. Cells were lysed, and cell lysates were subjected to SDS-PAGE and Western blotting for the detection of phospho-Akt at Se䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖 PARP / Cleaved PARP / Caspase-3 / Cleaved caspase-3 ; PubMed: 22739265 Chin J Cancer ATM inhibition by KU-55933 induces apoptosis in differentiated but not undifferentiated SH-SY5Y cells. Cells were starved for 6 h in serum-free medium. KU-55933 (10 µmol/L) was added 1 h before insulin (100 nmol/L) treatment. After 3 h of insulin stimulat䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤 ATM-S1981 / ATM / p-p53(S15) / p53 ; PubMed: 20639198 J Biol Chem Antioxidant and ATM inhibitors blocked phosphorylation of ATM-S1981, Akt-S473, and p53-S15 as stimulated by H2O2 exposure. Cells were treated with 100 μm H2O2 for 30 min in the absence or presence of KU-55933. Whole cell lysates were subjected to Western 䲧疝Ỵ疞㧀疜膉痘 瘿뾠ՂᾰƌՂĀ 㺣痖 p21 / p27 / p53 ; PubMed: 20177072 J Biol Chem HMGE cells were incubated for the indicated times with 1 μm KU-55933 or DMSO. Total protein extracts were analyzed by Western blotting for p21WAF1/CIP1, p27KIP1, p53, or β-actin.	22739265 20639198 20177072
Immunofluorescence	p-S824 KAP1 / ZEBRA ; PubMed: 28249048 PLoS Pathog HH514-16 cells were treated with NaB (upper panel) or NaB plus KU-55933 (1μM; middle panel) or NaB plus Torin1 (0.5μM; lower panel) for 24 hours and stained with anti-phospho KAP1 (S824) plus anti-ZEBRA antibodies and visualized at 1000X magnification.	28249048

体内研究

KU-55933抑制ATM依赖的STAT3激活，通过上调DR5表达增强TRAIL调节的凋亡,抑制STAT3 和NF-κB都和下调cFLIP有关，伴随着凋亡水平上升。ATM抑制剂KU-55933 影响TRAIL调节的凋亡的效果比JAK2抑制剂AG490或STAT3β过量表达都高。^[3]

激酶实验： ^[1]	- 合并纯化的酶实验: 通过免疫沉淀反应从HeLa核蛋白萃取中获得用于体外研究的ATM，在反应buffer中，把兔多克隆抗血清加到ATM羧基端第400个氨基酸处，buffer包含25 mM HEPES (pH为7.4), 2 mM MgCl₂, 250 mM KCl, 500 μM EDTA, 100 μM Na₃VO₄, 10% v/v 甘油, 及0.1% v/v Igepal。和蛋白A凝胶温育1小时，然后进行离心作用，从核蛋白中分离ATM抗体复合物。在96孔板中，包含ATM的凝胶珠和1 μg 底物GST-p53N66 (p53的氮端第66位氨基酸与GST融合)在ATM实验buffer中37^oC下温育，buffer包括25 mM HEPES (pH 为7.4), 75 mM NaCl, 3 mM MgCl₂, 2 mM MnCl₂, 50 μM Na₃VO₄, 500 μM DTT, 及5% v/v甘油。震荡10分钟后，加入ATP，最终浓度为50 μM，在37^oC反应持续1小时。按250×g转速4^oC下离心10分钟，除去ATM凝胶珠，上清液转移到96孔板上，在室温下温育1.5小时。然后用PBS冲洗，烘干，加入p-p53(Ser15)抗体用于ELISA分析。使用增强的化学发光溶液产生信号和化学发光。
细胞实验： ^[1]	- 合并 Cell lines: U2OS细胞 Concentrations: 10 μM Incubation Time: 2小时 Method: U2OS细胞经过电离辐射(3, 5, 或15 Gy) 或者UV处理(5或50 J/m2)，通过p-p53（Ser15）和p53 的Western blot分析而测定ATM反应。在不同时间点获得细胞萃取物，SDS-PAGE分离蛋白，加入p-p53(Ser15)抗体，ATM增多。加入p53抗体观察到p53随着时间变化趋于稳定。为了测定KU-55933的IC50值，使用p-p53(Ser15)抗体检测KU-55933抑制ATM的效果。KU-55933加到细胞中，预温育1小时，然后进行电离辐射。在体外，使用扫描密度测定法测定IC50值。 (Only for Reference)
动物实验： ^[3]	- 合并 Animal Models: 携带LU1205细胞的BALB/c nu/nu鼠 Dosages: 10 μM Administration: -- (Only for Reference)

参考文献

溶解度 (25°C)

体外	DMSO	33 mg/mL (83.44 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 5%DMSO+40%PEG300+5%Tween80+50%ddH2O	3.95 mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download KU-55933 (ATM Kinase Inhibitor) SDF

分子量	395.49
化学式	C₂₁H₁₇NO₃S₂
CAS号	587871-26-9
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

ATM/ATR Signaling Pathway Map

ATM/ATR Inhibitors with Unique Features

用于临床的ATM/ATR抑制剂

BEZ235 (NVP-BEZ235, Dactolisib) : Phase II for Advanced Endometrial Carcinoma.
最新的ATM/ATR抑制剂

VE-822 ^New : ATR inhibitor with IC50 of 19 nM.

研究领域

产品类型

定制您的化合物库

KU-55933 (ATM Kinase Inhibitor)

客户使用Selleck生产的KU-55933 (ATM Kinase Inhibitor)发表文献250篇：

产品安全说明书

ATM/ATR抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download KU-55933 (ATM Kinase Inhibitor) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

技术支持

ATM/ATR Signaling Pathway Map

ATM/ATR Inhibitors with Unique Features

相关ATM/ATR产品