KU-55933 (ATM Kinase Inhibitor)

目录号:S1092

仅限科研使用

KU-55933 (ATM Kinase Inhibitor)是一种有效的,特异性ATM抑制剂,在无细胞试验中IC50/Ki为12.9 nM/2.2 nM,与DNA-PK, PI3K/PI4K, ATR和mTOR相比,对ATM具有高度选择性。KU‑55933 (ATM Kinase Inhibitor)可抑制 autophagy‑initiating kinase ULK1 的激活从而导致自噬的显著减少。

KU-55933 (ATM Kinase Inhibitor) Chemical Structure

CAS: 587871-26-9

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 917.23 现货
RMB 571.66 现货
RMB 975.88 现货
RMB 3032.31 现货
大包装 有超大折扣

今日订购,明日送达 全国免运费 分装免费 分装成小规格产品(单支最小为1mg)
如1支10mg产品可分装为10支1mg产品

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的KU-55933 (ATM Kinase Inhibitor)发表文献285篇:

产品安全说明书

ATM/ATR抑制剂选择性比较

相关ATM/ATR产品

生物活性

产品描述 KU-55933 (ATM Kinase Inhibitor)是一种有效的,特异性ATM抑制剂,在无细胞试验中IC50/Ki为12.9 nM/2.2 nM,与DNA-PK, PI3K/PI4K, ATR和mTOR相比,对ATM具有高度选择性。KU‑55933 (ATM Kinase Inhibitor)可抑制 autophagy‑initiating kinase ULK1 的激活从而导致自噬的显著减少。
靶点
ATM [1]
(Cell-free assay)
12.9 nM
体外研究

KU-55933是有效的特定ATM抑制剂,IC50为13 nM,Ki值为2.2 nM。KU-55933也抑制DNA-PK和PI3K,IC50分别为2.5和16.6 μM。KU-55933也抑制mTOR活性,IC50为9.3 μM。KU-55933有效作用于ATM依赖的磷酸化作用。KU-55933抑制ATM依赖的磷酸化作用,存在剂量依赖性,IC50为300 nM。小于30 μM时,KU-58050不能抑制p53的ATM-依赖性磷酸化作用(位点为第15位丝氨酸)。在UV-诱导的H2AX(位点为第139位丝氨酸), NBS1(位点为第343为丝氨酸), CHK1(位点为第345位丝氨酸),及SMC1(位点为第966位丝氨酸)中,加入KU-55933没有明显作用效果。紫外处理时,KU-55933切除由电离辐射诱导的ATM磷酸化底物。KU-55933使HeLa细胞对电离辐射敏感。在癌细胞中,KU-55933抑制生长因子诱导的Akt的磷酸化作用。KU-55933抑制癌细胞增殖。KU-55933抑制ATM,通过阻断下游TAp63α的激活,提高存活力。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
DU-145 M2TPdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnwOoxKSzVyPUOuNlc{PTJizszN NYPj[mw5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HuO-3N1 NHfDOG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEX1WnRKSzVyPUSuNVcyPDJizszN Ml3pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
LAMA-84 Ml7IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vrPWlEPTB;ND61PFQ3PSEQvF2= NEThSnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
CAL-72 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXFVnhZUUN3ME21MlQ5ODh2IN88US=> MmPoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
LoVo NXnwU5E2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnlTWM2OD14LkmzNlM6KM7:TR?= MnXTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
HH NIHVTXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRThwMke2O|Eh|ryP MlryQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
SK-MEL-3 M3HO[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPYN2hOUUN3ME24MlI5PTd3IN88US=> M2jnW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
KM12 M2XEcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfBcFE2UUN3ME25MlIyOTR{IN88US=> MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NCI-H1437 NUjZe3BoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37LUGlEPTB;OT64NFk4KM7:TR?= Mne0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
NCI-H1838 NF7yZ4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDGTWM2OD1zMT6xPFY2KM7:TR?= NHzIepo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
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GOTO NGPlPVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTFzLk[5PVYh|ryP MlnrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
LB2241-RCC NF\CSI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3ERoVKSzVyPUGxMlcyQDZizszN NF;ERoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
ES7 Mn\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2n2W2lEPTB;MUGuO|g5KM7:TR?= NE\Udpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
KP-N-YS MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrkVVliUUN3ME2xNk43OzV2IN88US=> NFfFUpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
CAL-12T MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXEOIxKSzVyPUGzMlYyPyEQvF2= NVrNVIFJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
COLO-684 M2L4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfTTWM2OD1zND6xOVY6KM7:TR?= MkjvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
DOK MkjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnHTWM2OD1zNT6zN|I6KM7:TR?= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
Hs-578-T MkDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4D2cmlEPTB;MUWuOFE5OiEQvF2= NVPZSGNjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
D-423MG NHPsWndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPoTWM2OD1zNT61NlM3KM7:TR?= NWXHXWQ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
DBTRG-05MG M1jVbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moe4TWM2OD1zNT62NVEyKM7:TR?= NF6y[Hc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
VM-CUB-1 NWP3NIl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHnTWM2OD1zNT65PFQ6KM7:TR?= M2n5dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
KG-1 MkfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPRS4E2UUN3ME2xOk4xQTl4IN88US=> M{O2clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
8305C NVrUXpA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIP5[nBKSzVyPUG2MlE5QDlizszN MmrzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
HuH-7 NGDqelVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fBPGlEPTB;MU[uNlY4PCEQvF2= NWTJdG5NRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
LXF-289 NHX3XGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1y1TGlEPTB;MU[uNlc1PyEQvF2= NVexZYQ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
NCI-H1793 MoLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LkN2lEPTB;MU[uOFcyOiEQvF2= MlzIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
ChaGo-K-1 M2P4Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fBc2lEPTB;MU[uOlU3QCEQvF2= NUH0[mdrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
GCIY NWPQeVJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzneFFKSzVyPUG2Mlc6ODVizszN MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
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NCI-SNU-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELmcIhKSzVyPUG3MlEzPjlizszN NHfm[Wk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
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NCI-H82 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTF5LkS1O|Mh|ryP MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
HCC2998 M{LodGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzwe45KSzVyPUG3MlY4OzNizszN M3\GV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
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HuP-T3 NH7NOotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlX0TWM2OD1zOD61PFg5KM7:TR?= NX3WZ29ZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
697 NWjmO3k1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLTNVBKUUN3ME2xPU4xOjBzIN88US=> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
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HCC70 NG\meGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moq4TWM2OD1zOT60PFkh|ryP NGrFOpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
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DB MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;FVpdKSzVyPUO3MlkyQDVizszN MlfOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
IA-LM NVjs[GI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1uyWWlEPTB;M{iuNFI{QSEQvF2= M2TORVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
COLO-829 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3P3ZWlEPTB;M{iuOFE2QSEQvF2= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
TGBC11TKB M1y5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzsTWM2OD1|OT6xOFA5KM7:TR?= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
CAL-51 Mo[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLVTWM2OD12MD6wOlEzKM7:TR?= MmfhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
NCI-H2228 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1j1d2lEPTB;NECuN|Y3OiEQvF2= Ml;0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
C32 M4npW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF6yO3RKSzVyPUSwMlQxOjRizszN MoDFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
KU-19-19 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHlWVZKSzVyPUSwMlc3QDNizszN NIHKOW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
KNS-62 NYjSSnFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrLXXdDUUN3ME20NE45OzhzIN88US=> MojBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
FADU MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTGcWlKSzVyPUSxMlI2ODJizszN MoiyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
CAL-33 NULKdWoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTR{Lk[3OFkh|ryP NIPsWoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
CHP-134 NVjKbmxMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vTW2lEPTB;NEKuPFQ6PiEQvF2= M13LVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
HDLM-2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HrZWlEPTB;NEKuPVA5PCEQvF2= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NBsusSR NHTVSnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXT5RmFzUUN3ME20N{4xPzJ3IN88US=> MmTTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
SW954 MmTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzEd2hZUUN3ME20N{4yODV|IN88US=> M2HodlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
HCC1806 NGS2XVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHMSm1[UUN3ME20N{41OTFizszN MofxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
VMRC-RCZ MoP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTR|LkS1PFYh|ryP Mk\4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
A549 NYKycYx6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TIPWlEPTB;NEOuPVMyKM7:TR?= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NKM-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfP[mR[UUN3ME20N{46PTV6IN88US=> MlLXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
DMS-273 NIGy[opIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTR2Lke1Olch|ryP Mn;HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
TYK-nu NVW4PG4xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTR3LkGyN|Qh|ryP Mm\qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
KALS-1 NVPZflBJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTR3LkG0OkDPxE1? NUHLTJcxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
A101D NFHOWm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zy[mlEPTB;NEWuOFQ2PiEQvF2= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
G-361 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjPTWM2OD12Nj6yNVM5KM7:TR?= NXi4NotLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
KARPAS-299 NH7FVXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYn5R|I4UUN3ME20Ok4{PTF4IN88US=> MlX4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
RS4-11 NEXWRmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3MXG8{UUN3ME20Ok42PDJizszN NVTaVXdwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HT-1376 NIf3Z5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PkZmlEPTB;NE[uO|QzPiEQvF2= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
SK-N-AS M3PEbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTR4Lke4NlIh|ryP NFPSOYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
MG-63 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTR4LkmwN|Yh|ryP NYjCVnU6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
EPLC-272H NGC1PWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFz5bIpKSzVyPUS2Mlk2ODNizszN NGHoO489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
BALL-1 NF3DS3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTR5LkizNkDPxE1? MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
LCLC-97TM1 NV3Lc2N2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Tje2lEPTB;NEiuNlAzKM7:TR?= MofKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
HO-1-N-1 NUnIZ2ZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TxOWlEPTB;NEiuPVY4PiEQvF2= MkDDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
MFE-280 NITsVGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWO5eIl2UUN3ME20PU41PjF5IN88US=> NWfvZWpWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
NCI-H526 MnHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmi4TWM2OD12OT64NVY{KM7:TR?= NVr5NXp2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
D-566MG MkHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEe0U5NKSzVyPUS5MlkxQTZizszN M4XWbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
BB30-HNC NV;X[YFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrrPWg6UUN3ME20PU46PDl6IN88US=> NX\KXndSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
SK-N-DZ NILzTYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3:xPGlEPTB;NUCuNFQ5OSEQvF2= NGP5SZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
HepG2  MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPHNVDDqM7:TR?= MoDCNlQhcA>? NX63fnBT[myxY3vzJHNENUmLSUOtbY5lfWOnZDDTJJBp[XOnIHHydoV{fA>? M4HJRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUK3NVI{Lz5{NUWyO|EzOzxxYU6=
HepG2  MV3GeY5kfGmxbjDBd5NigQ>? NH;nc|UyOMLizszN MXGyOEBp Mnrpd5VxeHKnc4Pld{B1cGVicHjvd5Bpd3K7bHH0bY9veyCxZjDBWG0hd25iU3XyNVk5OSxiQ3jrNUBwdiCVZYKzOFUtKEOqa{Kgc44hXGi{NkisJIFv\CCFZHuyJI9vKFS7ckG1JIlv\HWlZXSgZpkhW0NvSVnJNy=> M4C4N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUK3NVI{Lz5{NUWyO|EzOzxxYU6=
KATO III  NIe4PVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\6[G06Oi53L{WvO{42KM7:TR?= M1HlZWROW09? NFLIO5hmdmijbnPld{B1cGVidH;4bYNqfHlib3[gc4xieGG{aXK= NHjzcIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi0NVcyQCd-MkS4OFE4OTh:L3G+
hTCEpi Ml7US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3GdZZPOTBizszN MWnEUXNQ MoP2dJJmfmWwdIOgeIhmKGO7dH;wZZRpcWNiZX\m[YN1KG:oIFjTWk0y MojpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|N{C4N|UoRjJ2M{ewPFM2RC:jPh?=
MCF10A NW\1T|d3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYGxNEDPxE1? MYeyOEBp NHrmdWRFVVOR MnzDdI91\W62aXH0[ZMhfGinIHP5eI91d3irY3n0fUBw\iCJQR?= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF3MEW5OUc,OjRzNUC1PVU9N2F-
HL-60  M4rZeGZ2dmO2aX;uJGF{e2G7 M{jBOFExKM7:TR?= NWfKSVhoOC53IHi= NW[zVYxyTE2VTx?= NX;lT5g5emWmdXPld{BxcG:|cHjvdplt[XSrb36gc4YhS2itMtMg MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl|NESxNUc,OjN7M{S0NVE9N2F-
MCF-7 MnrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHKNU0yODEQvF2= NWHYfnFpOjRiaB?= MV;GRnM> MXrpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9v NUjFOHBnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxPFU{PDdpPkKzNVg2OzR5PD;hQi=>
HeLa  NVrvU3Y3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrOe4QyNTFyMN88US=> NVHHbo5IOjRiaB?= NUDJfWg6TkKV NGTFfFJqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:w NF3JSmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G4OVM1Pyd-MkOxPFU{PDd:L3G+
SH-SY5Y M1mxWmZ2dmO2aX;uJGF{e2G7 NEDWdlcyOMLizszNxsA> NV7MTop1OjRiaB?= NXW2SHlmcW6qaXLpeJMh[2yrb4H1bY5wdC2rbnT1Z4VlKHCqb4PwbI9zgWyjdHnvckBw\iCyNUO= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZ{N{K5OEc,OjJ4MkeyPVQ9N2F-
IMR-32 NHnie3pHfW6ldHnvckBCe3OjeR?= NVL1PHAzOTEEoN88UeKh MVKyOEBp MUfpcohq[mm2czDjcIlweXWrbn;sMYlv\HWlZXSgdIhwe3Cqb4L5cIF1cW:wIH;mJJA2Ow>? MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZ{N{K5OEc,OjJ4MkeyPVQ9N2F-
A549 MVXGeY5kfGmxbjDBd5NigQ>? NHHKbowyOMLizszNxsA> NHPy[nkyKGh? Ml7Bd5VxeHKnc4Pld{BP[W6xLVPvMYlv\HWlZXSgdFU{KGGlY4XteYxifGmxbh?= MnrPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3NUmzNlEoRjJ{NUW5N|IyRC:jPh?=
T47D  NW[1R3ZpTnWwY4Tpc44hSXO|YYm= NYnadm5qOjEEoH3N M4fSeFI1KGh? MYHEUXNQ NXzqcI9seHKndnXueJMhUVJvaX7keYNm\CCmZXfyZYRifGmxbjDv[kBK|rqEzsG= Ml3WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzNES4NFUoRjJzMUS0PFA2RC:jPh?=
A29 MEF NGG3fFVHfW6ldHnvckBCe3OjeR?= M1HHO|ExyqEQvF5CpC=> NWTQUGRPOWh? MnXUZoxw[2u|wrD0bIUheGixc4Doc5J6dGG2aX;uJI9nKEGtdDDheEBU\XJ2N{RCpC=> M2nnSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMEWzO|gyLz5{MEC1N|c5OTxxYU6=
MDA-MB-453  NVvoUXllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVO1MVQxKM7:TR?= NEC5VXU4OiCq M{DmOWlEPTBib3[gNVAh|ryP NXjr[IlzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOVM4QDFpPkKwNFU{PzhzPD;hQi=>
PC-3 NX34UGdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\ON242NTRyIN88US=> NGe3RVk4OiCq M4qyWWlEPTBib3[gNVAh|ryP M2DLZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMEWzO|gyLz5{MEC1N|c5OTxxYU6=
U2OS NEjkdFRHfW6ldHnvckBie3OjeR?= MYLJcohq[mm2aX;uJI9nKEGWTTDpckBpfW2jbjDVNm9UKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gdFU{KHCqb4PwbI9zgWyjdHnvckBifCCVZYKxOUBz\XOrZIXlMEBKSzVyIE2gNE4zPSEQvF2u M{\mRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkOyPVY2Lz5{Nk[zNlk3PTxxYU6=
MCF7 M{fSfGZ2dmO2aX;uJIF{e2G7 NWTIUGkzOSCqch?= NYLYdJliUW6qaXLpeIlwdiCxZjDBWG0hc2mwYYPlJIlvKGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgNUBpeiCkeTDpcY12dm:obIXvdoV{[2WwY3WgZZN{[XluIFnDOVAhRSByLkOg{txONg>? M4TGVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkOyPVY2Lz5{Nk[zNlk3PTxxYU6=
BJ M2TVOGZ2dmO2aX;uJIF{e2G7 NVy3UHc{OTBidV2= MYqxNEBl[Xm| MXPTeZBxemW|c3nvckBw\iC|ZX7ld4NmdmOnIHnuJIh2dWGwIFLKJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGOnbHygcpVu[mW{IHH0JFExKHWPIHHmeIVzKDFyIHThfZMh[nlic3Xu[ZNk\W6lZTDy[ZZmenOjbDDhd5NigQ>? MnvwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ5NkewPFUoRjF4N{[3NFg2RC:jPh?=
BJ MnjKSpVv[3Srb36gZZN{[Xl? M4\r[|ExKHWP M4X6cFExKGSjeYO= MnHHTY5pcWKrdHnvckBw\iCjdHH4bYEhfGWuYX7nbYVkfGG|aXGtcZV1[XSnZDDpckBpfW2jbjDCTkBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiClZXzsJI52dWKncjDheEAyOCC3TTDh[pRmeiBzMDDkZZl{KGK7IIPlcoV{[2WwY3WgdoV3\XK|YXygZZN{[Xl? NH:2Vo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNke2O|A5PSd-MU[3OlcxQDV:L3G+
MCF7 MlTHSpVv[3Srb36gZZN{[Xl? MVyxNEB2VQ>? MlPxNVAhdWmwcx?= MnTpV4Vve2m2aYrheIlwdiCxZjDpcoZz[XKnZD3pcoR2[2WmIFTORUBl[W2jZ3WgbY4hcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ49td267IH\vdo1ifGmxbjDheEAyOCC3TTDwdoV1emWjdHXkJIZweiBzMDDtbY5{KG[xbHzve4VlKGK7IHnydoFlcWG2aX;uJIZweiB2IHjyd{Bu\WG|dYLl[EBi\nSncjCxNEBl[Xm|IHL5JINzgXO2YXygeolwdGW2IIP0ZYlvcW6pIHHuZYx6e2m| M4jNZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkOyPVY2Lz5{Nk[zNlk3PTxxYU6=
SK-N-MC NXnSZ5Z3eUiWUzDhd5NigQ>? M3;CbpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSz3OMW1EKGOnbHzz MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
Assay
Methods Test Index PMID
Western blot p-AKT(Ser473) / p-AKT(Thr308) PARP / Cleaved PARP / Caspase-3 / Cleaved caspase-3 ATM-S1981 / ATM / p-p53(S15) / p53 p21 / p27 / p53 22739265 20639198 20177072
Immunofluorescence p-S824 KAP1 / ZEBRA 28249048
体内研究 KU-55933抑制ATM依赖的STAT3激活,通过上调DR5表达增强TRAIL调节的凋亡,抑制STAT3 和NF-κB都和下调cFLIP有关,伴随着凋亡水平上升。ATM抑制剂KU-55933 影响TRAIL调节的凋亡的效果比JAK2抑制剂AG490或STAT3β过量表达都高。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

  • 纯化的酶实验:

    通过免疫沉淀反应从HeLa核蛋白萃取中获得用于体外研究的ATM,在反应buffer中,把兔多克隆抗血清加到ATM羧基端第400个氨基酸处,buffer包含25 mM HEPES (pH为7.4), 2 mM MgCl2, 250 mM KCl, 500 μM EDTA, 100 μM Na3VO4, 10% v/v 甘油, 及0.1% v/v Igepal。和蛋白A凝胶温育1小时,然后进行离心作用,从核蛋白中分离ATM抗体复合物。在96孔板中,包含ATM的凝胶珠和1 μg 底物GST-p53N66 (p53的氮端第66位氨基酸与GST融合)在ATM实验buffer中37oC下温育,buffer包括25 mM HEPES (pH 为7.4), 75 mM NaCl, 3 mM MgCl2, 2 mM MnCl2, 50 μM Na3VO4, 500 μM DTT, 及5% v/v甘油。震荡10分钟后,加入ATP,最终浓度为50 μM,在37oC反应持续1小时。按250×g转速4oC下离心10分钟,除去ATM凝胶珠,上清液转移到96孔板上,在室温下温育1.5小时。然后用PBS冲洗,烘干,加入p-p53(Ser15)抗体用于ELISA分析。使用增强的化学发光溶液产生信号和化学发光。

细胞实验:

[1]

  • Cell lines: U2OS细胞
  • Concentrations: 10 μM
  • Incubation Time: 2小时
  • Method:

    U2OS细胞经过电离辐射(3, 5, 或15 Gy) 或者UV处理(5或50 J/m2),通过p-p53(Ser15)和p53 的Western blot分析而测定ATM反应。在不同时间点获得细胞萃取物,SDS-PAGE分离蛋白,加入p-p53(Ser15)抗体,ATM增多。加入p53抗体观察到p53随着时间变化趋于稳定。为了测定KU-55933的IC50值,使用p-p53(Ser15)抗体检测KU-55933抑制ATM的效果。KU-55933加到细胞中,预温育1小时,然后进行电离辐射。在体外,使用扫描密度测定法测定IC50值。

动物实验:

[3]

  • Animal Models: 携带LU1205细胞的BALB/c nu/nu鼠
  • Dosages: 10 μM
  • Administration: --

溶解度(25°C)

体外

体内

从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5%DMSO+40%PEG300+5%Tween80+50%ddH2O

3.95 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 395.49
化学式

C21H17NO3S2

CAS号 587871-26-9
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

技术支持

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操作手册

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