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KU-55933 (ATM Kinase Inhibitor)

目录号：S1092

仅限科研使用

KU-55933 (ATM Kinase Inhibitor)是一种有效的，特异性ATM抑制剂，在无细胞试验中IC50/K_i为12.9 nM/2.2 nM，与DNA-PK， PI3K/PI4K， ATR和mTOR相比，对ATM具有高度选择性。KU‑55933 (ATM Kinase Inhibitor)可抑制 autophagy‑initiating kinase ULK1 的激活从而导致自噬的显著减少。

KU-55933 (ATM Kinase Inhibitor) Chemical Structure

CAS: 587871-26-9

规格	价格	库存
10mM (1mL in DMSO)	RMB 917.23	现货
5mg	RMB 571.66	现货
10mg	RMB 975.88	现货
50mg	RMB 3032.31	现货
大包装	有超大折扣

今日订购，明日送达全国免运费分装免费分装成小规格产品（单支最小为1mg）如1支10mg产品可分装为10支1mg产品全国免费电话：400-668-6834 \| Email：info@selleck.cn

客户使用Selleck生产的KU-55933 (ATM Kinase Inhibitor)发表文献285篇：

产品安全说明书

ATM/ATR抑制剂选择性比较

生物活性

产品描述

靶点

ATM ^[1]
(Cell-free assay)

12.9 nM

体外研究

KU-55933是有效的特定ATM抑制剂，IC50为13 nM，K_i值为2.2 nM。KU-55933也抑制DNA-PK和PI3K，IC50分别为2.5和16.6 μM。KU-55933也抑制mTOR活性，IC50为9.3 μM。KU-55933有效作用于ATM依赖的磷酸化作用。KU-55933抑制ATM依赖的磷酸化作用，存在剂量依赖性，IC50为300 nM。小于30 μM时，KU-58050不能抑制p53的ATM-依赖性磷酸化作用（位点为第15位丝氨酸）。在UV-诱导的H2AX（位点为第139位丝氨酸）, NBS1（位点为第343为丝氨酸）, CHK1（位点为第345位丝氨酸）,及SMC1（位点为第966位丝氨酸）中，加入KU-55933没有明显作用效果。紫外处理时，KU-55933切除由电离辐射诱导的ATM磷酸化底物。KU-55933使HeLa细胞对电离辐射敏感。在癌细胞中，KU-55933抑制生长因子诱导的Akt的磷酸化作用。KU-55933抑制癌细胞增殖。KU-55933抑制ATM，通过阻断下游TAp63α的激活，提高存活力。^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

DU-145	M2TPdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGnwOoxKSzVyPUOuNlc{PTJizszN	NYPj[mw5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HuO-3N1	NHfDOG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEX1WnRKSzVyPUSuNVcyPDJizszN	Ml3pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
LAMA-84	Ml7IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3vrPWlEPTB;ND61PFQ3PSEQvF2=	NEThSnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
CAL-72	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXXFVnhZUUN3ME21MlQ5ODh2IN88US=>	MmPoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
LoVo	NXnwU5E2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnnlTWM2OD14LkmzNlM6KM7:TR?=	MnXTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
HH	NIHVTXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYLJR\|UxRThwMke2O\|Eh\|ryP	MlryQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
SK-MEL-3	M3HO[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUPYN2hOUUN3ME24MlI5PTd3IN88US=>	M2jnW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
KM12	M2XEcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVfBcFE2UUN3ME25MlIyOTR{IN88US=>	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NCI-H1437	NUjZe3BoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M37LUGlEPTB;OT64NFk4KM7:TR?=	Mne0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
NCI-H1838	NF7yZ4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkDGTWM2OD1zMT6xPFY2KM7:TR?=	NHzIepo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
J-RT3-T3-5	NWfJTVE{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFHoOmVKSzVyPUGxMlI1OTdizszN	MkD3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
GOTO	NGPlPVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVHJR\|UxRTFzLk[5PVYh\|ryP	MlnrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
LB2241-RCC	NF\CSI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NH3ERoVKSzVyPUGxMlcyQDZizszN	NF;ERoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
ES7	Mn\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2n2W2lEPTB;MUGuO\|g5KM7:TR?=	NE\Udpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
KP-N-YS	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWrkVVliUUN3ME2xNk43OzV2IN88US=>	NFfFUpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
CAL-12T	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEXEOIxKSzVyPUGzMlYyPyEQvF2=	NVrNVIFJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
COLO-684	M2L4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnfTTWM2OD1zND6xOVY6KM7:TR?=	MkjvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
DOK	MkjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmnHTWM2OD1zNT6zN\|I6KM7:TR?=	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
Hs-578-T	MkDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4D2cmlEPTB;MUWuOFE5OiEQvF2=	NVPZSGNjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
D-423MG	NHPsWndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MoPoTWM2OD1zNT61NlM3KM7:TR?=	NWXHXWQ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
DBTRG-05MG	M1jVbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Moe4TWM2OD1zNT62NVEyKM7:TR?=	NF6y[Hc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
VM-CUB-1	NWP3NIl2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnHnTWM2OD1zNT65PFQ6KM7:TR?=	M2n5dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
KG-1	MkfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXPRS4E2UUN3ME2xOk4xQTl4IN88US=>	M{O2clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
8305C	NVrUXpA3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIP5[nBKSzVyPUG2MlE5QDlizszN	MmrzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
HuH-7	NGDqelVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{fBPGlEPTB;MU[uNlY4PCEQvF2=	NWTJdG5NRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
LXF-289	NHX3XGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1y1TGlEPTB;MU[uNlc1PyEQvF2=	NVexZYQ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
NCI-H1793	MoLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3LkN2lEPTB;MU[uOFcyOiEQvF2=	MlzIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
ChaGo-K-1	M2P4Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4fBc2lEPTB;MU[uOlU3QCEQvF2=	NUH0[mdrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
GCIY	NWPQeVJVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHzneFFKSzVyPUG2Mlc6ODVizszN	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
SK-MEL-28	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3K5fWlEPTB;MUeuNFQ4PSEQvF2=	NXnRdJh2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
NCI-SNU-1	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NELmcIhKSzVyPUG3MlEzPjlizszN	NHfm[Wk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
CTB-1	NWDoTlhOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MorZTWM2OD1zNz6yNlU6KM7:TR?=	M1TjNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
NCI-H82	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUHJR\|UxRTF5LkS1O\|Mh\|ryP	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
HCC2998	M{LodGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHzwe45KSzVyPUG3MlY4OzNizszN	M3\GV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
NCI-H2030	NWDsfYpHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NITDUoNKSzVyPUG4MlE6QTdizszN	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
HuP-T3	NH7NOotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlX0TWM2OD1zOD61PFg5KM7:TR?=	NX3WZ29ZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
697	NWjmO3k1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYLTNVBKUUN3ME2xPU4xOjBzIN88US=>	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
MLMA	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWf4OZNCUUN3ME2xPU4xPTV5IN88US=>	NYXDeWVlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HCC70	NG\meGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Moq4TWM2OD1zOT60PFkh\|ryP	NGrFOpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
A704	M4LxR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYnJR\|UxRTF7LkizNFUh\|ryP	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
D-283MED	NUPEc5JPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYHJR\|UxRTJyLkWzN\|kh\|ryP	NXnoTpdORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
U031	NVm4VZdQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYfJR\|UxRTJzLkG0PFkh\|ryP	M2WwZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
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RVH-421	M4PGeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVP2PWtsUUN3ME2yO{4zQTJzIN88US=>	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
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A2780	NIHFdZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXniVXZiUUN3ME2yO{43PDFizszN	MojGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
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BHT-101	M2XMfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkTrTWM2OD1{OD62OVczKM7:TR?=	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
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HAL-01	M37mdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUjPeWZOUUN3ME2yPE44PjF3IN88US=>	NFfiU3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
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MHH-PREB-1	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUnJR\|UxRTN{Lk[yN\|Qh\|ryP	NXfCb3ZiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
OVCAR-4	NVL2U45HT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkDuTWM2OD1\|Mj64N\|Y{KM7:TR?=	NVXm[FBlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
NCI-H1648	Mn\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYDaNYxpUUN3ME2zNk45PjVzIN88US=>	Mk\xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
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HOP-92	M4ezcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{e4eWlEPTB;M{WuPVI4PyEQvF2=	NX3zPXN4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
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COLO-829	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3P3ZWlEPTB;M{iuOFE2QSEQvF2=	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
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CAL-51	Mo[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnLVTWM2OD12MD6wOlEzKM7:TR?=	MmfhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
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KU-19-19	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHHlWVZKSzVyPUSwMlc3QDNizszN	NIHKOW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
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CAL-33	NULKdWoyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVHJR\|UxRTR{Lk[3OFkh\|ryP	NIPsWoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
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HDLM-2	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2HrZWlEPTB;NEKuPVA5PCEQvF2=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NBsusSR	NHTVSnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXT5RmFzUUN3ME20N{4xPzJ3IN88US=>	MmTTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
SW954	MmTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXzEd2hZUUN3ME20N{4yODV\|IN88US=>	M2HodlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
HCC1806	NGS2XVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUHMSm1[UUN3ME20N{41OTFizszN	MofxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
VMRC-RCZ	MoP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWjJR\|UxRTR\|LkS1PFYh\|ryP	Mk\4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
A549	NYKycYx6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4TIPWlEPTB;NEOuPVMyKM7:TR?=	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NKM-1	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWfP[mR[UUN3ME20N{46PTV6IN88US=>	MlLXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
DMS-273	NIGy[opIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYjJR\|UxRTR2Lke1Olch\|ryP	Mn;HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
TYK-nu	NVW4PG4xT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUXJR\|UxRTR3LkGyN\|Qh\|ryP	Mm\qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
KALS-1	NVPZflBJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVvJR\|UxRTR3LkG0OkDPxE1?	NUHLTJcxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
A101D	NFHOWm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3zy[mlEPTB;NEWuOFQ2PiEQvF2=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
G-361	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnjPTWM2OD12Nj6yNVM5KM7:TR?=	NXi4NotLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
KARPAS-299	NH7FVXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYn5R\|I4UUN3ME20Ok4{PTF4IN88US=>	MlX4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
RS4-11	NEXWRmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NV3MXG8{UUN3ME20Ok42PDJizszN	NVTaVXdwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HT-1376	NIf3Z5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{PkZmlEPTB;NE[uO\|QzPiEQvF2=	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
SK-N-AS	M3PEbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MY\JR\|UxRTR4Lke4NlIh\|ryP	NFPSOYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
MG-63	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV;JR\|UxRTR4LkmwN\|Yh\|ryP	NYjCVnU6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
EPLC-272H	NGC1PWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFz5bIpKSzVyPUS2Mlk2ODNizszN	NGHoO489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
BALL-1	NF3DS3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXjJR\|UxRTR5LkizNkDPxE1?	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
LCLC-97TM1	NV3Lc2N2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1Tje2lEPTB;NEiuNlAzKM7:TR?=	MofKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
HO-1-N-1	NUnIZ2ZlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1TxOWlEPTB;NEiuPVY4PiEQvF2=	MkDDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
MFE-280	NITsVGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWO5eIl2UUN3ME20PU41PjF5IN88US=>	NWfvZWpWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
NCI-H526	MnHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mmi4TWM2OD12OT64NVY{KM7:TR?=	NVr5NXp2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
D-566MG	MkHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEe0U5NKSzVyPUS5MlkxQTZizszN	M4XWbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
BB30-HNC	NV;X[YFJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVrrPWg6UUN3ME20PU46PDl6IN88US=>	NX\KXndSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
SK-N-DZ	NILzTYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3:xPGlEPTB;NUCuNFQ5OSEQvF2=	NGP5SZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
HepG2	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnPHNVDDqM7:TR?=	MoDCNlQhcA>?		NX63fnBT[myxY3vzJHNENUmLSUOtbY5lfWOnZDDTJJBp[XOnIHHydoV{fA>?	M4HJRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUK3NVI{Lz5{NUWyO\|EzOzxxYU6=
HepG2	MV3GeY5kfGmxbjDBd5NigQ>?	NH;nc\|UyOMLizszN	MXGyOEBp		Mnrpd5VxeHKnc4Pld{B1cGVicHjvd5Bpd3K7bHH0bY9veyCxZjDBWG0hd25iU3XyNVk5OSxiQ3jrNUBwdiCVZYKzOFUtKEOqa{Kgc44hXGi{NkisJIFv\CCFZHuyJI9vKFS7ckG1JIlv\HWlZXSgZpkhW0NvSVnJNy=>	M4C4N\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUK3NVI{Lz5{NUWyO\|EzOzxxYU6=
KATO III	NIe4PVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NU\6[G06Oi53L{WvO{42KM7:TR?=		M1HlZWROW09?	NFLIO5hmdmijbnPld{B1cGVidH;4bYNqfHlib3[gc4xieGG{aXK=	NHjzcIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi0NVcyQCd-MkS4OFE4OTh:L3G+
hTCEpi	Ml7US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV3GdZZPOTBizszN		MWnEUXNQ	MoP2dJJmfmWwdIOgeIhmKGO7dH;wZZRpcWNiZX\m[YN1KG:oIFjTWk0y	MojpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|N{C4N\|UoRjJ2M{ewPFM2RC:jPh?=
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MDA-MB-453	NVvoUXllT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVO1MVQxKM7:TR?=	NEC5VXU4OiCq		M{DmOWlEPTBib3[gNVAh\|ryP	NXjr[IlzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOVM4QDFpPkKwNFU{PzhzPD;hQi=>
PC-3	NX34UGdvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF\ON242NTRyIN88US=>	NGe3RVk4OiCq		M4qyWWlEPTBib3[gNVAh\|ryP	M2DLZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMEWzO\|gyLz5{MEC1N\|c5OTxxYU6=
U2OS	NEjkdFRHfW6ldHnvckBie3OjeR?=				MYLJcohq[mm2aX;uJI9nKEGWTTDpckBpfW2jbjDVNm9UKGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gdFU{KHCqb4PwbI9zgWyjdHnvckBifCCVZYKxOUBz\XOrZIXlMEBKSzVyIE2gNE4zPSEQvF2u	M{\mRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkOyPVY2Lz5{Nk[zNlk3PTxxYU6=
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Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID

Western blot	p-AKT(Ser473) / p-AKT(Thr308) PARP / Cleaved PARP / Caspase-3 / Cleaved caspase-3 ATM-S1981 / ATM / p-p53(S15) / p53 p21 / p27 / p53	22739265 20639198 20177072
Immunofluorescence	p-S824 KAP1 / ZEBRA	28249048

体内研究

KU-55933抑制ATM依赖的STAT3激活，通过上调DR5表达增强TRAIL调节的凋亡,抑制STAT3 和NF-κB都和下调cFLIP有关，伴随着凋亡水平上升。ATM抑制剂KU-55933 影响TRAIL调节的凋亡的效果比JAK2抑制剂AG490或STAT3β过量表达都高。^[3]

激酶实验： ^[1]	纯化的酶实验: 通过免疫沉淀反应从HeLa核蛋白萃取中获得用于体外研究的ATM，在反应buffer中，把兔多克隆抗血清加到ATM羧基端第400个氨基酸处，buffer包含25 mM HEPES (pH为7.4), 2 mM MgCl₂, 250 mM KCl, 500 μM EDTA, 100 μM Na₃VO₄, 10% v/v 甘油, 及0.1% v/v Igepal。和蛋白A凝胶温育1小时，然后进行离心作用，从核蛋白中分离ATM抗体复合物。在96孔板中，包含ATM的凝胶珠和1 μg 底物GST-p53N66 (p53的氮端第66位氨基酸与GST融合)在ATM实验buffer中37^oC下温育，buffer包括25 mM HEPES (pH 为7.4), 75 mM NaCl, 3 mM MgCl₂, 2 mM MnCl₂, 50 μM Na₃VO₄, 500 μM DTT, 及5% v/v甘油。震荡10分钟后，加入ATP，最终浓度为50 μM，在37^oC反应持续1小时。按250×g转速4^oC下离心10分钟，除去ATM凝胶珠，上清液转移到96孔板上，在室温下温育1.5小时。然后用PBS冲洗，烘干，加入p-p53(Ser15)抗体用于ELISA分析。使用增强的化学发光溶液产生信号和化学发光。
细胞实验： ^[1]	Cell lines: U2OS细胞 Concentrations: 10 μM Incubation Time: 2小时 Method: U2OS细胞经过电离辐射(3, 5, 或15 Gy) 或者UV处理(5或50 J/m2)，通过p-p53（Ser15）和p53 的Western blot分析而测定ATM反应。在不同时间点获得细胞萃取物，SDS-PAGE分离蛋白，加入p-p53(Ser15)抗体，ATM增多。加入p53抗体观察到p53随着时间变化趋于稳定。为了测定KU-55933的IC50值，使用p-p53(Ser15)抗体检测KU-55933抑制ATM的效果。KU-55933加到细胞中，预温育1小时，然后进行电离辐射。在体外，使用扫描密度测定法测定IC50值。
动物实验： ^[3]	Animal Models: 携带LU1205细胞的BALB/c nu/nu鼠 Dosages: 10 μM Administration: --

参考文献	[1] Hickson I, et al. Cancer Res. 2004, 64(24), 9152-9159. [2] Soleimani R, et al. Aging. 2011, 3(8), 782-793. [3] Ivanov VN, et al. Cancer Res. 2009, 69(8), 3510-3519.

溶解度（25°C）

体外


体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 5%DMSO+40%PEG300+5%Tween80+50%ddH2O 点击购买： PEG300 Tween 80	3.95 mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量	395.49
化学式	C₂₁H₁₇NO₃S₂
CAS号	587871-26-9
储存条件	3年	-20°C	粉状
储存条件	2年	-80°C	溶于溶剂

Download KU-55933 (ATM Kinase Inhibitor) SDF

动物体内配方计算器（澄清溶液）

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 μL 动物数量只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO + % + % Tween 80 + % ddH2O

%DMSO+ %

计算结果：

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH₂O，混匀澄清。

体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。

注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×

稀释计算器分子量计算器

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