KU-55933 (ATM Kinase Inhibitor)

For research use only. Not for use in humans.

目录号:S1092

KU-55933 (ATM Kinase Inhibitor) Chemical Structure

CAS No. 587871-26-9

KU-55933 (ATM Kinase Inhibitor)是一种有效的,特异性ATM抑制剂,在无细胞试验中IC50/Ki为12.9 nM/2.2 nM,与DNA-PK, PI3K/PI4K, ATR和mTOR相比,对ATM具有高度选择性。KU‑55933 (ATM Kinase Inhibitor)可抑制 autophagy‑initiating kinase ULK1 的激活从而导致自噬的显著减少。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 917.23 现货
RMB 571.66 现货
RMB 975.88 现货
RMB 3032.31 现货
RMB 7755.93 现货
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客户使用Selleck生产的KU-55933 (ATM Kinase Inhibitor)发表文献222篇:

产品安全说明书

ATM/ATR抑制剂选择性比较

生物活性

产品描述 KU-55933 (ATM Kinase Inhibitor)是一种有效的,特异性ATM抑制剂,在无细胞试验中IC50/Ki为12.9 nM/2.2 nM,与DNA-PK, PI3K/PI4K, ATR和mTOR相比,对ATM具有高度选择性。KU‑55933 (ATM Kinase Inhibitor)可抑制 autophagy‑initiating kinase ULK1 的激活从而导致自噬的显著减少。
靶点
ATM [1]
(Cell-free assay)
12.9 nM
体外研究

KU-55933是有效的特定ATM抑制剂,IC50为13 nM,Ki值为2.2 nM。KU-55933也抑制DNA-PK和PI3K,IC50分别为2.5和16.6 μM。KU-55933也抑制mTOR活性,IC50为9.3 μM。KU-55933有效作用于ATM依赖的磷酸化作用。KU-55933抑制ATM依赖的磷酸化作用,存在剂量依赖性,IC50为300 nM。小于30 μM时,KU-58050不能抑制p53的ATM-依赖性磷酸化作用(位点为第15位丝氨酸)。在UV-诱导的H2AX(位点为第139位丝氨酸), NBS1(位点为第343为丝氨酸), CHK1(位点为第345位丝氨酸),及SMC1(位点为第966位丝氨酸)中,加入KU-55933没有明显作用效果。紫外处理时,KU-55933切除由电离辐射诱导的ATM磷酸化底物。KU-55933使HeLa细胞对电离辐射敏感。在癌细胞中,KU-55933抑制生长因子诱导的Akt的磷酸化作用。KU-55933抑制癌细胞增殖。KU-55933抑制ATM,通过阻断下游TAp63α的激活,提高存活力。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
DU-145 NETvOIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LncGlEPTB;Mz6yO|M2OiEQvF2= NHXMRWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
HuO-3N1 M{TL[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVm4epNqUUN3ME20MlE4OTR{IN88US=> M2PCTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
LAMA-84 M1;HUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInxV5JKSzVyPUSuOVg1PjVizszN NXu3SmFVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
CAL-72 M1jjeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jOZWlEPTB;NT60PFA5PCEQvF2= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
LoVo NYHpPGtsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPRTWM2OD14LkmzNlM6KM7:TR?= M{\ncVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
HH MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRThwMke2O|Eh|ryP M{TlPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
SK-MEL-3 NEHRbXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjzfnZKSzVyPUiuNlg2PzVizszN MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
KM12 NVPKNnpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjnfHVKSzVyPUmuNlEyPDJizszN M4nBcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
NCI-H1437 M1izXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnVe2tKSzVyPUmuPFA6PyEQvF2= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NCI-H1838 MnnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXsTWM2OD1zMT6xPFY2KM7:TR?= MlfPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
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GOTO M{nlUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLOVpJmUUN3ME2xNU43QTl4IN88US=> NI\WSFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
LB2241-RCC NITzZVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2OzTGlEPTB;MUGuO|E5PiEQvF2= MlS0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
ES7 NV3QSZFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTFzLke4PEDPxE1? NGTUZ5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
KP-N-YS NF7xV3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfabmpNUUN3ME2xNk43OzV2IN88US=> M2HwXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
CAL-12T MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTF|Lk[xO{DPxE1? MlvsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
COLO-684 MmnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXES4RKSzVyPUG0MlE2PjlizszN M{Hpc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
DOK MnrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfOT3FKSzVyPUG1MlM{OjlizszN MmXyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
Hs-578-T NF6ySXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTF3LkSxPFIh|ryP M1e0b|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
D-423MG MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[zd2xHUUN3ME2xOU42OjN4IN88US=> MoDTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
DBTRG-05MG MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFGxdFJKSzVyPUG1MlYyOTFizszN MnPwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
VM-CUB-1 NX;Id41rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYX5bIpNUUN3ME2xOU46QDR7IN88US=> NYDJWGpMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
KG-1 M3noZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnmTWM2OD1zNj6wPVk3KM7:TR?= NIjnU3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
8305C MkLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\BUHl{UUN3ME2xOk4yQDh7IN88US=> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
HuH-7 NGPReppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmC4TWM2OD1zNj6yOlc1KM7:TR?= M1XMW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
LXF-289 MlT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorvTWM2OD1zNj6yO|Q4KM7:TR?= NE\kdHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
NCI-H1793 M{fFUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2KzTGlEPTB;MU[uOFcyOiEQvF2= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
ChaGo-K-1 NHLwdm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTF4Lk[1Olgh|ryP M1;KdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
GCIY M3\TXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUW2bI5SUUN3ME2xOk44QTB3IN88US=> M13uR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
SK-MEL-28 Mm\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmj3TWM2OD1zNz6wOFc2KM7:TR?= M{\PNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
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CTB-1 MkTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTF5LkKyOVkh|ryP MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NCI-H82 NV;HPGtHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnNT2ZyUUN3ME2xO{41PTd|IN88US=> MlvOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
HCC2998 NYftV29kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFWzOJVKSzVyPUG3MlY4OzNizszN NXm3fVF6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
NCI-H2030 NEWxfnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHH6fZZKSzVyPUG4MlE6QTdizszN M4DLcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
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CAL-33 NH:2VpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nUfmlEPTB;NEKuOlc1QSEQvF2= NGjpfZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
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HDLM-2 NYT4NWpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LNTGlEPTB;NEKuPVA5PCEQvF2= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
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DMS-273 NFHKeWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn74TWM2OD12ND63OVY4KM7:TR?= NWPndpJURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
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KALS-1 M3zXPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTR3LkG0OkDPxE1? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
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KARPAS-299 NFrDZoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTR4LkO1NVYh|ryP NGniSoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
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EPLC-272H Mn3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHqzTmZKSzVyPUS2Mlk2ODNizszN NIfhdJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
BALL-1 M3;wc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTR5LkizNkDPxE1? NF7Xd5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK|5USU6JRWK8M4E,
LCLC-97TM1 M3XDPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrYUXlMUUN3ME20PE4zODJizszN M2Pae|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
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HepG2  NGizRYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXOS2pEOTEEoN88US=> MlLsNlQhcA>? MmTsZoxw[2u|IGPDMWlKUTNvaX7keYNm\CCVIIDoZZNmKGG{cnXzeC=> NIDSZ3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUWyO|EzOyd-MkW1NlcyOjN:L3G+
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HeLa  NIDqelJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XYR|EuOTByzszN NHzrN4wzPCCq NX30eYZbTkKV NETJc2pqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:w MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF6NUO0O{c,OjNzOEWzOFc9N2F-
SH-SY5Y MlfhSpVv[3Srb36gRZN{[Xl? M2jnelExyqEQvF5CpC=> MV:yOEBp NUDMUGRtcW6qaXLpeJMh[2yrb4H1bY5wdC2rbnT1Z4VlKHCqb4PwbI9zgWyjdHnvckBw\iCyNUO= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZ{N{K5OEc,OjJ4MkeyPVQ9N2F-
IMR-32 MnXkSpVv[3Srb36gRZN{[Xl? MlewNVDDqM7:TdMg MVeyOEBp NU\KTJdFcW6qaXLpeJMh[2yrb4H1bY5wdC2rbnT1Z4VlKHCqb4PwbI9zgWyjdHnvckBw\iCyNUO= MkDFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ4MkeyPVQoRjJ{NkK3Nlk1RC:jPh?=
A549 M36yeGZ2dmO2aX;uJGF{e2G7 NHX6d4QyOMLizszNxsA> NUjOdHo{OSCq MmXId5VxeHKnc4Pld{BP[W6xLVPvMYlv\HWlZXSgdFU{KGGlY4XteYxifGmxbh?= NHrKU2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW1PVMzOSd-MkK1OVk{OjF:L3G+
T47D  MWDGeY5kfGmxbjDBd5NigQ>? M33PV|IxyqCvTR?= MnPINlQhcA>? M{To[2ROW09? M4X0PZBz\X[nboTzJGlTNWmwZIXj[YQh\GWpcnHkZZRqd25ib3[gTe67Ss7z M1PaRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUS0PFA2Lz5{MUG0OFgxPTxxYU6=
A29 MEF MXzGeY5kfGmxbjDBd5NigQ>? MlTDNVDDqM7:TdMg M4jxeFFp M4HPfYJtd2Otc9MgeIhmKHCqb4PwbI9zgWyjdHnvckBw\iCDa4SgZZQhW2W{NEezxsA> MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB3M{e4NUc,OjByNUO3PFE9N2F-
MDA-MB-453  M1zmS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rYW|UuPDBizszN MVG3NkBp MkjwTWM2OCCxZjCxNEDPxE1? NXu5OpA4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOVM4QDFpPkKwNFU{PzhzPD;hQi=>
PC-3 M3K4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUe1MVQxKM7:TR?= M{S3NFczKGh? M3[5N2lEPTBib3[gNVAh|ryP M3r4dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMEWzO|gyLz5{MEC1N|c5OTxxYU6=
U2OS MXnGeY5kfGmxbjDhd5NigQ>? NFHCZY1KdmirYnn0bY9vKG:oIFHUUUBqdiCqdX3hckBWOk:VIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YheDV|IIDoc5NxcG:{eXzheIlwdiCjdDDT[ZIyPSC{ZYPp[JVmNCCLQ{WwJF0hOC5{NTFOwG0v NIXndHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[zNlk3PSd-Mk[2N|I6PjV:L3G+
MCF7 NF[0OGRHfW6ldHnvckBie3OjeR?= MYGxJIhz MWXJcohq[mm2aX;uJI9nKEGWTTDrbY5ie2ViaX6gbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiBzIHjyJIJ6KGmvbYXuc4ZtfW:{ZYPj[Y5k\SCjc4PhfUwhUUN3MDC9JFAvOyEQvF2u M2foSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkOyPVY2Lz5{Nk[zNlk3PTxxYU6=
BJ NEj4blNHfW6ldHnvckBie3OjeR?= Mkm3NVAhfU1? NXLMZ2luOTBiZHH5dy=> NV62XWVTW3WycILld5Nqd25ib3[gd4Vv\XOlZX7j[UBqdiCqdX3hckBDUiClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDj[YxtKG63bXLldkBifCBzMDD1UUBi\nSncjCxNEBl[Xm|IHL5JJNmdmW|Y3XuZ4UhemW4ZYLzZYwh[XO|YYm= NFzWemc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNke2O|A5PSd-MU[3OlcxQDV:L3G+
BJ M3u0b2Z2dmO2aX;uJIF{e2G7 NEDXeIMyOCC3TR?= MnfSNVAh\GG7cx?= NUjReIE2UW6qaXLpeIlwdiCxZjDheIF5cWFidHXsZY5ocWWldHHzbYEudXW2YYTl[EBqdiCqdX3hckBDUiClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDj[YxtKG63bXLldkBifCBzMDD1UUBi\nSncjCxNEBl[Xm|IHL5JJNmdmW|Y3XuZ4UhemW4ZYLzZYwh[XO|YYm= M4fj[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4N{[3NFg2Lz5zNke2O|A5PTxxYU6=
MCF7 MlHXSpVv[3Srb36gZZN{[Xl? MUCxNEB2VQ>? NX;1dY5QOTBibXnudy=> NF\4[HdU\W6|aYTpfoF1cW:wIH;mJIlv\nKjcnXkMYlv\HWlZXSgSG5CKGSjbXHn[UBqdiCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBkd2yxbomg[o9zdWG2aX;uJIF1KDFyIIXNJJBz\XS{ZXH0[YQh\m:{IEGwJI1qdnNiZn;scI94\WRiYomgbZJz[WSrYYTpc44h\m:{IESgbJJ{KG2nYYP1doVlKGGodHXyJFExKGSjeYOgZpkh[3K7c4ThcEB3cW:uZYSgd5RicW6rbnegZY5idHm|aYO= MmD0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4M{K5OlUoRjJ4NkOyPVY2RC:jPh?=
SK-N-MC M2nPTpFJXFNiYYPzZZk> MoC4dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tUWMh[2WubIO= NV3nTotSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT(Ser473) / p-AKT(Thr308); 

PubMed: 22739265     


Cells were serum-starved for 6 h and treated with KU-55933 (10 µmol/L) for 1 h before treatment with insulin (100 nmol/L) for 45 min. Cells were lysed, and cell lysates were subjected to SDS-PAGE and Western blotting for the detection of phospho-Akt at Se䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖

PARP / Cleaved PARP / Caspase-3 / Cleaved caspase-3 ; 

PubMed: 22739265     


ATM inhibition by KU-55933 induces apoptosis in differentiated but not undifferentiated SH-SY5Y cells. Cells were starved for 6 h in serum-free medium. KU-55933 (10 µmol/L) was added 1 h before insulin (100 nmol/L) treatment. After 3 h of insulin stimulat䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤

ATM-S1981 / ATM / p-p53(S15) / p53 ; 

PubMed: 20639198     


Antioxidant and ATM inhibitors blocked phosphorylation of ATM-S1981, Akt-S473, and p53-S15 as stimulated by H2O2 exposure. Cells were treated with 100 μm H2O2 for 30 min in the absence or presence of KU-55933. Whole cell lysates were subjected to Western 䲧疝Ỵ疞㧀疜膉痘 瘿뾠ՂᾰƌՂĀ 㺣痖

p21 / p27 / p53 ; 

PubMed: 20177072     


HMGE cells were incubated for the indicated times with 1 μm KU-55933 or DMSO. Total protein extracts were analyzed by Western blotting for p21WAF1/CIP1, p27KIP1, p53, or β-actin.

22739265 20639198 20177072
Immunofluorescence
p-S824 KAP1 / ZEBRA ; 

PubMed: 28249048     


HH514-16 cells were treated with NaB (upper panel) or NaB plus KU-55933 (1μM; middle panel) or NaB plus Torin1 (0.5μM; lower panel) for 24 hours and stained with anti-phospho KAP1 (S824) plus anti-ZEBRA antibodies and visualized at 1000X magnification.

28249048
体内研究 KU-55933抑制ATM依赖的STAT3激活,通过上调DR5表达增强TRAIL调节的凋亡,抑制STAT3 和NF-κB都和下调cFLIP有关,伴随着凋亡水平上升。ATM抑制剂KU-55933 影响TRAIL调节的凋亡的效果比JAK2抑制剂AG490或STAT3β过量表达都高。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

纯化的酶实验:

通过免疫沉淀反应从HeLa核蛋白萃取中获得用于体外研究的ATM,在反应buffer中,把兔多克隆抗血清加到ATM羧基端第400个氨基酸处,buffer包含25 mM HEPES (pH为7.4), 2 mM MgCl2, 250 mM KCl, 500 μM EDTA, 100 μM Na3VO4, 10% v/v 甘油, 及0.1% v/v Igepal。和蛋白A凝胶温育1小时,然后进行离心作用,从核蛋白中分离ATM抗体复合物。在96孔板中,包含ATM的凝胶珠和1 μg 底物GST-p53N66 (p53的氮端第66位氨基酸与GST融合)在ATM实验buffer中37oC下温育,buffer包括25 mM HEPES (pH 为7.4), 75 mM NaCl, 3 mM MgCl2, 2 mM MnCl2, 50 μM Na3VO4, 500 μM DTT, 及5% v/v甘油。震荡10分钟后,加入ATP,最终浓度为50 μM,在37oC反应持续1小时。按250×g转速4oC下离心10分钟,除去ATM凝胶珠,上清液转移到96孔板上,在室温下温育1.5小时。然后用PBS冲洗,烘干,加入p-p53(Ser15)抗体用于ELISA分析。使用增强的化学发光溶液产生信号和化学发光。
细胞实验:

[1]

- 合并
  • Cell lines: U2OS细胞
  • Concentrations: 10 μM
  • Incubation Time: 2小时
  • Method:

    U2OS细胞经过电离辐射(3, 5, 或15 Gy) 或者UV处理(5或50 J/m2),通过p-p53(Ser15)和p53 的Western blot分析而测定ATM反应。在不同时间点获得细胞萃取物,SDS-PAGE分离蛋白,加入p-p53(Ser15)抗体,ATM增多。加入p53抗体观察到p53随着时间变化趋于稳定。为了测定KU-55933的IC50值,使用p-p53(Ser15)抗体检测KU-55933抑制ATM的效果。KU-55933加到细胞中,预温育1小时,然后进行电离辐射。在体外,使用扫描密度测定法测定IC50值。


    (Only for Reference)
动物实验:

[3]

- 合并
  • Animal Models: 携带LU1205细胞的BALB/c nu/nu鼠
  • Dosages: 10 μM
  • Administration: --
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 33 mg/mL (83.44 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5%DMSO+40%PEG300+5%Tween80+50%ddH2O
3.95 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 395.49
化学式

C21H17NO3S2

CAS号 587871-26-9
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

ATM/ATR Signaling Pathway Map

ATM/ATR Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID