KU-55933 (ATM Kinase Inhibitor)

For research use only. Not for use in humans.

目录号：S1092

KU-55933 (ATM Kinase Inhibitor) Chemical Structure

CAS No. 587871-26-9

KU-55933 (ATM Kinase Inhibitor)是一种有效的，特异性ATM抑制剂，在无细胞试验中IC50/K_i为12.9 nM/2.2 nM，与DNA-PK， PI3K/PI4K， ATR和mTOR相比，对ATM具有高度选择性。KU‑55933 (ATM Kinase Inhibitor)可抑制 autophagy‑initiating kinase ULK1 的激活从而导致自噬的显著减少。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 917.23	现货
5mg	RMB 571.66	现货
10mg	RMB 975.88	现货
50mg	RMB 3032.31	现货
200mg	RMB 7755.93	现货
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客户使用Selleck生产的KU-55933 (ATM Kinase Inhibitor)发表文献262篇：

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产品安全说明书

ATM/ATR抑制剂选择性比较

生物活性

产品描述

靶点

ATM ^[1]
(Cell-free assay)

12.9 nM

体外研究

KU-55933是有效的特定ATM抑制剂，IC50为13 nM，K_i值为2.2 nM。KU-55933也抑制DNA-PK和PI3K，IC50分别为2.5和16.6 μM。KU-55933也抑制mTOR活性，IC50为9.3 μM。KU-55933有效作用于ATM依赖的磷酸化作用。KU-55933抑制ATM依赖的磷酸化作用，存在剂量依赖性，IC50为300 nM。小于30 μM时，KU-58050不能抑制p53的ATM-依赖性磷酸化作用（位点为第15位丝氨酸）。在UV-诱导的H2AX（位点为第139位丝氨酸）, NBS1（位点为第343为丝氨酸）, CHK1（位点为第345位丝氨酸）,及SMC1（位点为第966位丝氨酸）中，加入KU-55933没有明显作用效果。紫外处理时，KU-55933切除由电离辐射诱导的ATM磷酸化底物。KU-55933使HeLa细胞对电离辐射敏感。在癌细胞中，KU-55933抑制生长因子诱导的Akt的磷酸化作用。KU-55933抑制癌细胞增殖。KU-55933抑制ATM，通过阻断下游TAp63α的激活，提高存活力。^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
DU-145	MkTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVG2N21GUUN3ME2zMlI4OzV{IN88US=>	MmrhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
HuO-3N1	M2Lze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkPzTWM2OD12LkG3NVQzKM7:TR?=	NUfzcYx4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
LAMA-84	M3PY[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MX\JR\|UxRTRwNUi0OlUh\|ryP	Moe3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
CAL-72	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYPwVYRLUUN3ME21MlQ5ODh2IN88US=>	NF\QRWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
LoVo	NVXyeoN2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFjmTFNKSzVyPU[uPVMzOzlizszN	NWLPbZVERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HH	NFLPemhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVe2dnZyUUN3ME24MlI4PjdzIN88US=>	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
SK-MEL-3	MnroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Ml2yTWM2OD16LkK4OVc2KM7:TR?=	M2ey[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
KM12	M2[2SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NF3he29KSzVyPUmuNlEyPDJizszN	NV7pPGpMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
NCI-H1437	M4TwXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2nqc2lEPTB;OT64NFk4KM7:TR?=	MlTnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
NCI-H1838	M4niZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3vYUWlEPTB;MUGuNVg3PSEQvF2=	NYi4eFF6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
J-RT3-T3-5	NXvTSGZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn7QTWM2OD1zMT6yOFE4KM7:TR?=	M{[0O\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
GOTO	NEfMdWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mn3ETWM2OD1zMT62PVk3KM7:TR?=	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
LB2241-RCC	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEi0RW9KSzVyPUGxMlcyQDZizszN	NFjXV5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
ES7	NI\5RZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUfJR\|UxRTFzLke4PEDPxE1?	NWCw[Hp5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
KP-N-YS	M{L3emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MULJR\|UxRTF{Lk[zOVQh\|ryP	NHf1dYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
CAL-12T	Mo\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHL4OoxKSzVyPUGzMlYyPyEQvF2=	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
COLO-684	MmiyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXLJR\|UxRTF2LkG1Olkh\|ryP	NHLwZ2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
DOK	NYq0OoJlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkDqTWM2OD1zNT6zN\|I6KM7:TR?=	M2O4SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
Hs-578-T	MlXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYPJR\|UxRTF3LkSxPFIh\|ryP	NFKzdlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
D-423MG	Mm\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXzTXXE{UUN3ME2xOU42OjN4IN88US=>	Mnn5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
DBTRG-05MG	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmfZTWM2OD1zNT62NVEyKM7:TR?=	NGX0c3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
VM-CUB-1	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MX\JR\|UxRTF3Lkm4OFkh\|ryP	NH64R5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
KG-1	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NX;zOnRiUUN3ME2xOk4xQTl4IN88US=>	NILubFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
8305C	NULnRlA5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXzMT4U3UUN3ME2xOk4yQDh7IN88US=>	NYnqNJlpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HuH-7	M1mzO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3jDTGlEPTB;MU[uNlY4PCEQvF2=	NHvEfZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
LXF-289	MmX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NETMeGNKSzVyPUG2MlI4PDdizszN	NVHMeYx{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
NCI-H1793	M4XlZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NH3jO3lKSzVyPUG2MlQ4OTJizszN	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
ChaGo-K-1	M3rBeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnHnTWM2OD1zNj62OVY5KM7:TR?=	NWnU[HVFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
GCIY	NUH5ToVvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXrJR\|UxRTF4Lke5NFUh\|ryP	NVHQfIJXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
SK-MEL-28	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGPnTnZKSzVyPUG3MlA1PzVizszN	M{fFd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
NCI-SNU-1	NH[z[Y9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYTJR\|UxRTF5LkGyOlkh\|ryP	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
CTB-1	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVjWcFg3UUN3ME2xO{4zOjV7IN88US=>	MmHUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
NCI-H82	M3LmT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWi3TZJ[UUN3ME2xO{41PTd\|IN88US=>	NI\kOpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
HCC2998	M4rHXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NV[2ZZBOUUN3ME2xO{43PzN\|IN88US=>	NHH4XGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
NCI-H2030	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWS4RZBSUUN3ME2xPE4yQTl5IN88US=>	M3nnelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
HuP-T3	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYS5d4tHUUN3ME2xPE42QDh6IN88US=>	NVfTOVB4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
697	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MX7JR\|UxRTF7LkCyNFEh\|ryP	M13GSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
MLMA	MmTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUfIT2h6UUN3ME2xPU4xPTV5IN88US=>	NU\XT45nRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
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EPLC-272H	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NF3aZ3FKSzVyPUS2Mlk2ODNizszN	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
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BB30-HNC	NVLFZXBZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoX1TWM2OD12OT65OFk5KM7:TR?=	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
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HepG2	MmrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoTCNVDDqM7:TR?=	NXn3fo5QOjRiaB?=		NH\KfHljdG:la4OgV2MuUUmLMz3pcoR2[2WmIGOgdIhie2ViYYLy[ZN1	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTV{N{GyN{c,OjV3MkexNlM9N2F-
HepG2	MYfGeY5kfGmxbjDBd5NigQ>?	NVHnWllGOTEEoN88US=>	M2f1Z\|I1KGh?		Mmj0d5VxeHKnc4Pld{B1cGVicHjvd5Bpd3K7bHH0bY9veyCxZjDBWG0hd25iU3XyNVk5OSxiQ3jrNUBwdiCVZYKzOFUtKEOqa{Kgc44hXGi{NkisJIFv\CCFZHuyJI9vKFS7ckG1JIlv\HWlZXSgZpkhW0NvSVnJNy=>	NYPLV2U2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1NlcyOjNpPkK1OVI4OTJ\|PD;hQi=>
KATO III	MkPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4DhN\|IvPS93L{euOUDPxE1?		MljUSG1UVw>?	NEC1VWdmdmijbnPld{B1cGVidH;4bYNqfHlib3[gc4xieGG{aXK=	NX7WNHhMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4OFE4OThpPkK0PFQyPzF6PD;hQi=>
hTCEpi	NVfIUW5YT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVOxNEDPxE1?		M3PjUmROW09?	NFLmT4VxemW4ZX70d{B1cGViY4n0c5BifGirYzDl[oZm[3Rib3[gTHNXNTF?	NV;Ve5diRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzO\|A5OzVpPkK0N\|cxQDN3PD;hQi=>
MCF10A	NGPyNIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4rDclExKM7:TR?=	NXK0SVRZOjRiaB?=	MWfEUXNQ	MnvjdI91\W62aXH0[ZMhfGinIHP5eI91d3irY3n0fUBw\iCJQR?=	MnPQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzNUC1PVUoRjJ2MUWwOVk2RC:jPh?=
HL-60	NX;qc4hDTnWwY4Tpc44hSXO\|YYm=	M1rQSVExKM7:TR?=	NXLNXoZsOC53IHi=	MmDMSG1UVw>?	MV;y[YR2[2W\|IIDoc5NxcG:{eXzheIlwdiCxZjDDbIszyqB?	Mm\rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7M{S0NVEoRjJ\|OUO0OFEyRC:jPh?=
MCF-7	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3XGclEuOTByzszN	MnzXNlQhcA>?	NIW2bZhHSlN?	MoG1bY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdg>?	NU\H[oR7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxPFU{PDdpPkKzNVg2OzR5PD;hQi=>
HeLa	M{LzS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWWxMVExOM7:TR?=	NWjGUVk2OjRiaB?=	Mom1SmJU	M{Lqc4lvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25?	MnS0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzOEWzOFcoRjJ\|MUi1N\|Q4RC:jPh?=
SH-SY5Y	MojiSpVv[3Srb36gRZN{[Xl?	MVmxNOKh\|ryPwrC=	MkXENlQhcA>?		NE\mfXhqdmirYnn0d{BkdGmxcYXpco9tNWmwZIXj[YQheGixc4Doc5J6dGG2aX;uJI9nKHB3Mx?=	NETsZ3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[yO\|I6PCd-MkK2NlczQTR:L3G+
IMR-32	MlH2SpVv[3Srb36gRZN{[Xl?	NGLHXpgyOMLizszNxsA>	MmToNlQhcA>?		MXfpcohq[mm2czDjcIlweXWrbn;sMYlv\HWlZXSgdIhwe3Cqb4L5cIF1cW:wIH;mJJA2Ow>?	NIfYfYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[yO\|I6PCd-MkK2NlczQTR:L3G+
A549	NWTMVIRxTnWwY4Tpc44hSXO\|YYm=	NGDMd2YyOMLizszNxsA>	M3rtVFEhcA>?		MVPzeZBxemW\|c3XzJG5idm9vQ3:tbY5lfWOnZDDwOVMh[WOldX31cIF1cW:w	Ml\pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3NUmzNlEoRjJ{NUW5N\|IyRC:jPh?=
T47D	MlTnSpVv[3Srb36gRZN{[Xl?	MUmyNOKhdU1?	Ml7BNlQhcA>?	MlrkSG1UVw>?	MlHydJJmfmWwdIOgTXIucW6mdXPl[EBl\We{YXTheIlwdiCxZjDJ{tpD\|rF?	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF2NEiwOUc,OjFzNES4NFU9N2F-
A29 MEF	M4\mVGZ2dmO2aX;uJGF{e2G7	MWexNOKh\|ryPwrC=	MojmNYg>		NVvNPGpI[myxY3vzxsB1cGVicHjvd5Bpd3K7bHH0bY9vKG:oIFHreEBifCCVZYK0O\|PDqA>?	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB3M{e4NUc,OjByNUO3PFE9N2F-
MDA-MB-453	Mli1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4H2Z\|UuPDBizszN	MYS3NkBp		NWX6THF1UUN3MDDv[kAyOCEQvF2=	NFWx[2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEC1N\|c5OSd-MkCwOVM4QDF:L3G+
PC-3	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn;0OU01OCEQvF2=	NYXBSXB7PzJiaB?=		M3T5U2lEPTBib3[gNVAh\|ryP	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB3M{e4NUc,OjByNUO3PFE9N2F-
U2OS	MojoSpVv[3Srb36gZZN{[Xl?				NIfyR2ZKdmirYnn0bY9vKG:oIFHUUUBqdiCqdX3hckBWOk:VIHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YheDV\|IIDoc5NxcG:{eXzheIlwdiCjdDDT[ZIyPSC{ZYPp[JVmNCCLQ{WwJF0hOC5{NTFOwG0v	M2ToVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkOyPVY2Lz5{Nk[zNlk3PTxxYU6=
MCF7	M{C3WGZ2dmO2aX;uJIF{e2G7		MWmxJIhz		M2rPRmlvcGmkaYTpc44hd2ZiQWTNJItqdmG\|ZTDpckBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEGgbJIh[nliaX3teY5w\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwJF0hOC5\|IN88UU4>	NULsTnY6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2N\|I6PjVpPkK2OlMzQTZ3PD;hQi=>
BJ	MkLaSpVv[3Srb36gZZN{[Xl?	NU\1TWlzOTBidV2=	NVnPeGlUOTBiZHH5dy=>		MUnTeZBxemW\|c3nvckBw\iC\|ZX7ld4NmdmOnIHnuJIh2dWGwIFLKJINmdGy\|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGOnbHygcpVu[mW{IHH0JFExKHWPIHHmeIVzKDFyIHThfZMh[nlic3Xu[ZNk\W6lZTDy[ZZmenOjbDDhd5NigQ>?	NVf0fnExRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[3OlcxQDVpPkG2O\|Y4ODh3PD;hQi=>
BJ	MmD6SpVv[3Srb36gZZN{[Xl?	NXn3VG17OTBidV2=	Mme5NVAh\GG7cx?=		MnzqTY5pcWKrdHnvckBw\iCjdHH4bYEhfGWuYX7nbYVkfGG\|aXGtcZV1[XSnZDDpckBpfW2jbjDCTkBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiClZXzsJI52dWKncjDheEAyOCC3TTDh[pRmeiBzMDDkZZl{KGK7IIPlcoV{[2WwY3WgdoV3\XK\|YXygZZN{[Xl?	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd4N{C4OUc,OTZ5NkewPFU9N2F-
MCF7	NHvQSFNHfW6ldHnvckBie3OjeR?=	NUDMRoIzOTBidV2=	Mny1NVAhdWmwcx?=		MmfrV4Vve2m2aYrheIlwdiCxZjDpcoZz[XKnZD3pcoR2[2WmIFTORUBl[W2jZ3WgbY4hcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ49td267IH\vdo1ifGmxbjDheEAyOCC3TTDwdoV1emWjdHXkJIZweiBzMDDtbY5{KG[xbHzve4VlKGK7IHnydoFlcWG2aX;uJIZweiB2IHjyd{Bu\WG\|dYLl[EBi\nSncjCxNEBl[Xm\|IHL5JINzgXO2YXygeolwdGW2IIP0ZYlvcW6pIHHuZYx6e2m\|	NFHvSIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[zNlk3PSd-Mk[2N\|I6PjV:L3G+
SK-N-MC	M1X6XpFJXFNiYYPzZZk>				MULxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?=	NGHHc4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-AKT(Ser473) / p-AKT(Thr308); PubMed: 22739265 Chin J Cancer Cells were serum-starved for 6 h and treated with KU-55933 (10 µmol/L) for 1 h before treatment with insulin (100 nmol/L) for 45 min. Cells were lysed, and cell lysates were subjected to SDS-PAGE and Western blotting for the detection of phospho-Akt at Se䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖 PARP / Cleaved PARP / Caspase-3 / Cleaved caspase-3 ; PubMed: 22739265 Chin J Cancer ATM inhibition by KU-55933 induces apoptosis in differentiated but not undifferentiated SH-SY5Y cells. Cells were starved for 6 h in serum-free medium. KU-55933 (10 µmol/L) was added 1 h before insulin (100 nmol/L) treatment. After 3 h of insulin stimulat䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤 ATM-S1981 / ATM / p-p53(S15) / p53 ; PubMed: 20639198 J Biol Chem Antioxidant and ATM inhibitors blocked phosphorylation of ATM-S1981, Akt-S473, and p53-S15 as stimulated by H2O2 exposure. Cells were treated with 100 μm H2O2 for 30 min in the absence or presence of KU-55933. Whole cell lysates were subjected to Western 䲧疝Ỵ疞㧀疜膉痘 瘿뾠ՂᾰƌՂĀ 㺣痖 p21 / p27 / p53 ; PubMed: 20177072 J Biol Chem HMGE cells were incubated for the indicated times with 1 μm KU-55933 or DMSO. Total protein extracts were analyzed by Western blotting for p21WAF1/CIP1, p27KIP1, p53, or β-actin.	22739265 20639198 20177072
Immunofluorescence	p-S824 KAP1 / ZEBRA ; PubMed: 28249048 PLoS Pathog HH514-16 cells were treated with NaB (upper panel) or NaB plus KU-55933 (1μM; middle panel) or NaB plus Torin1 (0.5μM; lower panel) for 24 hours and stained with anti-phospho KAP1 (S824) plus anti-ZEBRA antibodies and visualized at 1000X magnification.	28249048

体内研究

KU-55933抑制ATM依赖的STAT3激活，通过上调DR5表达增强TRAIL调节的凋亡,抑制STAT3 和NF-κB都和下调cFLIP有关，伴随着凋亡水平上升。ATM抑制剂KU-55933 影响TRAIL调节的凋亡的效果比JAK2抑制剂AG490或STAT3β过量表达都高。^[3]

激酶实验： ^[1]	- 合并纯化的酶实验: 通过免疫沉淀反应从HeLa核蛋白萃取中获得用于体外研究的ATM，在反应buffer中，把兔多克隆抗血清加到ATM羧基端第400个氨基酸处，buffer包含25 mM HEPES (pH为7.4), 2 mM MgCl₂, 250 mM KCl, 500 μM EDTA, 100 μM Na₃VO₄, 10% v/v 甘油, 及0.1% v/v Igepal。和蛋白A凝胶温育1小时，然后进行离心作用，从核蛋白中分离ATM抗体复合物。在96孔板中，包含ATM的凝胶珠和1 μg 底物GST-p53N66 (p53的氮端第66位氨基酸与GST融合)在ATM实验buffer中37^oC下温育，buffer包括25 mM HEPES (pH 为7.4), 75 mM NaCl, 3 mM MgCl₂, 2 mM MnCl₂, 50 μM Na₃VO₄, 500 μM DTT, 及5% v/v甘油。震荡10分钟后，加入ATP，最终浓度为50 μM，在37^oC反应持续1小时。按250×g转速4^oC下离心10分钟，除去ATM凝胶珠，上清液转移到96孔板上，在室温下温育1.5小时。然后用PBS冲洗，烘干，加入p-p53(Ser15)抗体用于ELISA分析。使用增强的化学发光溶液产生信号和化学发光。
细胞实验： ^[1]	- 合并 Cell lines: U2OS细胞 Concentrations: 10 μM Incubation Time: 2小时 Method: U2OS细胞经过电离辐射(3, 5, 或15 Gy) 或者UV处理(5或50 J/m2)，通过p-p53（Ser15）和p53 的Western blot分析而测定ATM反应。在不同时间点获得细胞萃取物，SDS-PAGE分离蛋白，加入p-p53(Ser15)抗体，ATM增多。加入p53抗体观察到p53随着时间变化趋于稳定。为了测定KU-55933的IC50值，使用p-p53(Ser15)抗体检测KU-55933抑制ATM的效果。KU-55933加到细胞中，预温育1小时，然后进行电离辐射。在体外，使用扫描密度测定法测定IC50值。 (Only for Reference)
动物实验： ^[3]	- 合并 Animal Models: 携带LU1205细胞的BALB/c nu/nu鼠 Dosages: 10 μM Administration: -- (Only for Reference)

参考文献

溶解度 (25°C)

体外	DMSO	33 mg/mL (83.44 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 5%DMSO+40%PEG300+5%Tween80+50%ddH2O	3.95 mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download KU-55933 (ATM Kinase Inhibitor) SDF

分子量	395.49
化学式	C₂₁H₁₇NO₃S₂
CAS号	587871-26-9
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

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ATM/ATR Signaling Pathway Map

ATM/ATR Inhibitors with Unique Features

用于临床的ATM/ATR抑制剂

BEZ235 (NVP-BEZ235, Dactolisib) : Phase II for Advanced Endometrial Carcinoma.
最新的ATM/ATR抑制剂

VE-822 ^New : ATR inhibitor with IC50 of 19 nM.

研究领域

产品类型

定制您的化合物库

KU-55933 (ATM Kinase Inhibitor)

客户使用Selleck生产的KU-55933 (ATM Kinase Inhibitor)发表文献262篇：

产品安全说明书

ATM/ATR抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download KU-55933 (ATM Kinase Inhibitor) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

技术支持

ATM/ATR Signaling Pathway Map

ATM/ATR Inhibitors with Unique Features

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