VE-821

For research use only. Not for use in humans.

目录号：S8007

CAS No. 1232410-49-9

VE-821是一种有效的，选择性的，ATP竞争性ATR抑制剂，在无细胞试验中K_i/IC50为13 nM/26 nM，抑制H2AX磷酸化，对PIKKs ATM， DNA-PK， mTOR和PI3Kγ具有很低的抑制活性。

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10mM (1mL in DMSO)	RMB 1550.64	现货
10mg	RMB 1205.85	现货
50mg	RMB 3846.28	现货
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客户使用Selleck生产的VE-821发表文献164篇：

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Nature, 2019, 10.1038/s41586-019-1607-3

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Cancer Cell, 2019, 35(5):752-766

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Nature, 2018, 555(7696):387-391

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Nat Genet, 2017, 49(4):537-549

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Nature, 2016, 539(7627):54-58

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Nature, 2015, 518(7538):254-7

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Mol Cell, 2021, S1097-2765(20)30951-5

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Cell Rep, 2021, 34(11):108870

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Cells, 2021, 10(3)532

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Cell Death Differ, 2021, 10.1038/s41418-020-00733-4

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EMBO J, 2021, e106336

PubMed: 33595114 ( click the link to review the publication )

BMC Biol, 2021, 19(1):35

PubMed: 33607997 ( click the link to review the publication )

Adv Sci (Weinh), 2020, 7(20):2000157

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Nat Commun, 2020, 11(1):4828

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Nat Commun, 2020, 26;11(1):2641

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Nat Commun, 2020, 8;11(1):2876

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Sci Adv, 2020, 6(24):eaaz7808

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EMBO J, 2020, 1;39(7):e102668

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Cell Rep, 2020, 32(9):108096

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Cell Rep, 2020, 32(9):108080

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J Hematol Oncol, 2020, 1;13(1):40

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mBio, 2020, 11(1)

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Cancers (Basel), 2020, 30;12(5):E1118

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PLoS Pathog, 2020, 16(6):e1008514

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Arch Toxicol, 2020, 10.1007/s00204-020-02712-7

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Mol Oncol, 2020, 26

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Mol Cancer Res, 2020, 10.1158/1541-7786.MCR-19-0507

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Cell Cycle, 2020, 1-17

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Int J Biochem Cell Biol, 2020, 121:105705

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Med Oncol, 2020, 10;37(5):47

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PLoS One, 2020, 15(1):e0223463

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Diagnostics (Basel), 2020, 10(2)

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J Biol Chem, 2020, jbc.RA120.13726

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Sci Rep, 2020, 10(1):2200

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Am J Physiol Gastrointest Liver Physiol, 2020, 10.1152/ajpgi.00329.2019

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Hum Gene Ther, 2020, 31(5-6):385-395

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Cancers (Basel), 2020, 12(6):1490

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Nat Commun, 2020, 11(1):3951

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Int J Radiat Oncol Biol Phys, 2020, 10.1016/j.ijrobp.2020.01.030

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NAR Cancer, 2020, 2(2):zcaa006

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Nat Commun, 2020, 11(1):123

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Mol Cell, 2019, 10.1016/j.molcel.2019.10.008

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Mol Cell, 2019, 73(4):670-683.e12

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Nat Commun, 2019, 10(1):2910

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Nucleic Acids Res, 2019, 10.1093/nar/gkz518

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Genes Dev, 2019, 33(19-20):1397-1415

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Cancer Res, 2019, 79(1):99-113

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J Cell Biol, 2019, 218(7):2113-2123

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Cell Rep, 2019, 29(3):551-559

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Cell Rep, 2019, 27(6):1794-1808

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PLoS Pathog, 2019, 15(2):e1007442

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Br J Cancer, 2019, 121(7):600-610

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Cancer Discov, 2019, 9(9):1306-1323

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Mol Cancer Ther, 2019, 18(8):1439-1450

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Mol Cancer Ther, 2019, 10.1158/1535-7163.MCT-19-0474

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Mol Oncol, 2019, 13(2):290-306

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Neoplasia, 2019, 21(12):1143-1150

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Hum Mol Genet, 2019, 28(5):842-857

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Oncogenesis, 2019, 8(7):38

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Biochim Biophys Acta Mol Cell Res, 2019, 1866(5):882-895

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J Cell Physiol, 2019, 234(11):21294-21306

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J Virol, 2019, 93(14)

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J Virol, 2019, 93(9)

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Toxicol Sci, 2019, 10.1093/toxsci/kfz178

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J Biol Chem, 2019, 294(8):2827-2838

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Mol Cell Biol, 2019, 39(8)e00488-18

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BMC Genomics, 2019, 20(1):579

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Chem Res Toxicol, 2019, 32(6):1123-1133

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Open Biol, 2019, 9(9):190156

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PLoS One, 2019, 14(11):e0221288

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Photochem Photobiol, 2019, 10.1111/php.13164

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Anticancer Res, 2019, 39(7):3553-3563

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Sci Adv, 2019, 5(5):eaav3235

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Haematologica, 2019, 10.3324/haematol.2018.215210

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Nucleic Acids Res, 2019, 47(21):10977-10993

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Nucleic Acids Res, 2019, 47(16):8838-8859

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Mutat Res, 2019, 816-818:111678

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Mol Cell, 2018, 69(5):879-892.e5

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Nat Commun, 2018, 9(1):5351

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Nat Commun, 2018, 9(1):764

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Nat Commun, 2018, 9(1):3923

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Nucleic Acids Res, 2018, 46(10):5029-5049

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Nucleic Acids Res, 2018, 46(19):10119-10131

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Nucleic Acids Res, 2018, 46(19):10132-10144

PubMed: 30184135 ( click the link to review the publication )

Cancer Res, 2018, 78(18):5363-5374

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Cell Rep, 2018, 25(12):3273-3282.e6

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Cell Rep, 2018, 24(10):2629-2642

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Int J Cancer, 2018,

PubMed: 29363109 ( click the link to review the publication )

mBio, 2018, 9(2)e02393-17

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FASEB J, 2018, 32(4):1818-1829

PubMed: 29162700 ( click the link to review the publication )

FASEB J, 2018, 32(7):3502-3517

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Mol Cancer Ther, 2018, 17(12):2551-2563

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J Virol, 2018, 92(6)

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Toxicol Appl Pharmacol, 2018, 355:238-246

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Cell Cycle, 2018, 17(5):595-604

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Cell Biol Int, 2018, 42(7):781-793

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Nucleic Acids Res, 2018, 46(7):3468-3486

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Nucleic Acids Res, 2018, 46(16):8311-8325

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Oncotarget, 2018, 9(17): 13474–13487

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J Biol Chem, 2018, 293(49):19025-19037

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Blood, 2017, 129(21):2882-2895

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Nat Commun, 2017, 8(1):1921

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EMBO J, 2017, 2;36(9):1261-1278

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Dev Cell, 2017, 40(4):405-420.e2

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Genes Dev, 2017, 31(3):318-332

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Cancer Res, 2017, 77(17):4567-4578

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J Cell Biol, 2017, 216(3):623-639

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EMBO Rep, 2017, 18(5):781-796

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Cell Rep, 2017, 18(8):1970-1981

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PLoS Pathog, 2017, 13(3):e1006266

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Oncogenesis, 2017, 6(6):e349

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Sci Rep, 2017, 7(1):16115

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J Biol Chem, 2017, 292(30):12424-12435

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BMC Cancer, 2017, 17(1):338

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Exp Dermatol, 2017, 26(7):577-584

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Oncotarget, 2017, 8(4):6461-6474

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Oncotarget, 2017, 8(14):23492-23506

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DNA Repair (Amst), 2017, 54:30-39

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Nat Commun, 2016, 10.1038/ncomms10660

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EMBO J, 2016, 35(23):2584-2601

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J Cell Biol, 2016, 212(4):399-408

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Blood Cancer J, 2016, 6(9):e465

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Elife, 2016, 10.7554/eLife.15129

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PLoS Pathog, 2016, 12(2):e1005424

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Hum Mol Genet, 2016, 25(8):1574-87

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Cell Discov, 2016, 2:16016

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Cell Discov, 2016, 2:16047

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Mol Cancer Res, 2016, 14(5):437-47

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Front Oncol, 2016, 6:186

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J Cell Sci, 2016, 129(16):3167-77

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Sci Rep, 2016, 6:19567

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Proteomics, 2016, 16(3):402-16

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Mol Biol Cell, 2016, 10.1091/mbc.E16-01-0032

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Cell Cycle, 2016, 15(4):546-58

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PLoS One, 2016, 11(12):e0167454

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Nucleic Acids Res, 2016, 44(11):5204-17

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Nucleic Acids Res, 2016, 44(8):3695-712

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Oncotarget, 2016, 7(35):56826-56841

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Oncotarget, 2016, 7(31):49800-49818

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Genes Dev, 2015, 29(18):1969-79

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Cell Rep, 2015, 13(8):1623-32

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Oncogene, 2015, 34(25):3336-48

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Gynecol Oncol, 2015, 136(3):554-61

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J Biol Chem, 2015, 290(19):12184-94

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J Biol Chem, 2015, 10.1074/jbc.M115.658419

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Cancer Biol Ther, 2015, 16(11):1585-92

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Int J Radiat Biol, 2015, 10.3109/09553002.2015.1029595

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Mutat Res, 2015, 771:36-44

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Oncotarget, 2015, 6(25):21074-84

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Oncotarget, 2015, 6(15):13072-87

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Elife, 2014, 3:e02443

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Oncogene, 2014, 10.1038/onc.2014.268

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Br J Pharmacol, 2014, 10.1111/bph.13046

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PLoS Genet, 2014, 10(11):e1004753

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Toxicol Sci, 2014, 10.1093/toxsci/kfu207

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J Biol Chem, 2014, 289(35):24314-24

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Mol Cell Biol, 2014, 34(21):3939-54

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Cell Cycle, 2014, 13(18):2901-12

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Radiat Res, 2014, 181(6):650-8

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Oncotarget, 2014, 5(21):10546-57

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产品安全说明书

ATM/ATR抑制剂选择性比较

生物活性

产品描述

靶点

ATR ^[1]
(Cell-free assay)

13 nM(Ki)

体外研究

VE-821作用于ATR，具有优异的选择性，作用于相关的PIKKs ATM, DNA-PK, mTOR 和PI3K，具有最低的交叉反应性，K_i分别为16 μM, 2.2 μM, >1 μM和 3.9 μM。VE-821单独使用，可使大部分癌细胞群体死亡，但作用于正常细胞，只可逆地限制细胞周期进程，产生最低的死亡或长期的有害影响。VE-821与Cisplatin联合处理，具有最显著的协同作用。^[1]VE-821抑制H2AX细胞生长，IC50为800 nM。^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
U2OS	MorLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MYnJR\|Ux973gMD64JO69VQ>?	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTV7M{G4OEc,OjV3OUOxPFQ9N2F-
SAOS2	M3z5dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M3jwT2lEPTExv[6wMlgh\|ryP	Mlf2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3OUOxPFQoRjJ3NUmzNVg1RC:jPh?=
CAL72	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NFjTVZJKSzVy784eNE45KM7:TR?=	MmnjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3OUOxPFQoRjJ3NUmzNVg1RC:jPh?=
NOS1	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MmTmTWM2OO,;nkCuPEDPxE1?	M33nRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUmzNVg1Lz5{NUW5N\|E5PDxxYU6=
HUO9	MkLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M3u0XGlEPTExv[6wMlgh\|ryP	M2jtZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUmzNVg1Lz5{NUW5N\|E5PDxxYU6=
MG63	NFnaeHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NVXMOIRxUUN3MP-9olkh\|ryP	M4n6elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUmzNVg1Lz5{NUW5N\|E5PDxxYU6=
SJSA1	NFTaUGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M4HMNmlEPTExv[65JO69VQ>?	NW\tcI5[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1PVMyQDRpPkK1OVk{OTh2PD;hQi=>
MDA-MB-231	NYPsOIpXS3m2b4TvfIlkcXS7IFHzd4F6	NF7YeWIyNzNxMUCg{txO	M{nETFEhcA>?	NXHESld5eG:2ZX70bYF1\XNidHjlJIN6fG:2b4jpZ4l1gSCxZjDic5RpKGOjbYD0c5Rp\WOrbjDhcoQhVE2SLUSwNC=>	MmHNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{Nkm0O\|koRjJ3Mk[5OFc6RC:jPh?=
HT-29	MULDfZRwfG:6aXPpeJkhSXO\|YYm=	NIHzWYcyNzNxMUCg{txO	MVqxJIg>	M1n0cJBwfGWwdHnheIV{KHSqZTDjfZRwfG:6aXPpeJkhd2ZiYn;0bEBk[W2ydH;0bIVkcW5iYX7kJGxOWC12MEC=	NIr6e2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK2PVQ4QSd-MkWyOlk1Pzl:L3G+
HCT-116 p53+/+	M2X1PGN6fG:2b4jpZ4l1gSCDc4PhfS=>	NFn0fnkyNzNxMUCg{txO	NES0VG4yKGh?	MX\wc5RmdnSrYYTld{B1cGViY4n0c5RwgGmlaYT5JI9nKGKxdHigZ4FueHSxdHjlZ4lvKGGwZDDMUXAuPDBy	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ4OUS3PUc,OjV{Nkm0O\|k9N2F-
HCT-116 p53-/-	MYrDfZRwfG:6aXPpeJkhSXO\|YYm=	MkO3NU8{NzFyIN88US=>	M{\vPVEhcA>?	M{TCR5BwfGWwdHnheIV{KHSqZTDjfZRwfG:6aXPpeJkhd2ZiYn;0bEBk[W2ydH;0bIVkcW5iYX7kJGxOWC12MEC=	NUDYXnViRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyOlk1PzlpPkK1NlY6PDd7PD;hQi=>
TF-1	MorwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{\wT\|AvODFz4pETPEDPxE1?	Mn;RPVYhcA>?	M3KzWYVvcGGwY3XzJJRp\SCjboTpdJJwdGmoZYLheIl3\SCnZn\lZ5R{KG:oIF3LNVc4PQ>?	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF5OUG1Nkc,OjRzN{mxOVI9N2F-
HEL	NHTLZllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoPXNE4xOTIkgKO4JO69VQ>?	NWm0OYlXQTZiaB?=	NWWwN\|lU\W6qYX7j[ZMhfGinIHHueIlxem:uaX\ldoF1cX[nIHXm[oVkfHNib3[gUWsyPzd3	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF5OUG1Nkc,OjRzN{mxOVI9N2F-
THP-1	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGTVbY0xNjBzMfMAl\|gh\|ryP	NHHrU2c6PiCq	MUflcohidmOnczD0bIUh[W62aYDyc4xq\mW{YYTpeoUh\W[oZXP0d{Bw\iCPS{G3O\|U>	M3joZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUe5NVUzLz5{NEG3PVE2OjxxYU6=
HL-60	M13OcGZ2dmO2aX;uJGF{e2G7	NXTvOHVPOTBibV2=	NIrhcWUxNjViaB?=	MVfy[YR2[2W\|IIDoc5NxcG:{eXzheIlwdiCxZjDDbIsyKGG2IIPldolv\SB\|NEW=	M4rmfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OUO0OFEyLz5{M{mzOFQyOTxxYU6=
OVCAR-8	MUPGeY5kfGmxbjDBd5NigQ>?	M3e3XVEhyrWPwrC=	NE\oXGQzPCCq	MVPhZpJw\2G2ZYOgZ4hmdW:2aHXyZZB6NWmwZIXj[YQh[2WubDDjfYNt\SCjcoLld5Q>	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV2OEK2PUc,OjN3NEiyOlk9N2F-
PANC-1	NWPXfpFbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2Pj[\|AvOTFvOTFOwG0>	M{n0PVEhcA>?	NIfnPVZqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNSCmZYDlcoRmdnRibXHucoVz	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh{NUOzNUc,OjJ6MkWzN\|E9N2F-
MiaPaCa	NIDYc5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlnNNE4yOS17IN88US=>	Mlm1NUBp	NGDuOFJqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNSCmZYDlcoRmdnRibXHucoVz	M4fxUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEK1N\|MyLz5{MkiyOVM{OTxxYU6=
PSN-1	M3Lzemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXOwMlEyNTlizszN	NEPjU3UyKGh?	M{XEeolvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBqdiCjIHTvd4UuKGSncHXu[IVvfCCvYX7u[ZI>	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh{NUOzNUc,OjJ6MkWzN\|E9N2F-
K562	MYrBdI9xfG:\|aYOgZZN{[Xl?	M1niVlExKHWP	MXy0PEBpenN?	NE\sVVlKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m\|IHnuJIh2dWGwIFu1OlIh[2WubIOgZZN{\XO\|ZXSgZZMh\2GvbXHINmFZNzV\|QmCxJIxmfmWuczDheEAyOCC3TTDh[pRmeiB2ODDodpMh[nliRFHQTUB{fGGrbnnu[{Bj[XOnZDDpcY12dm:obIXvdoV{[2WwY3WgcYlkem:\|Y3;wfUBqdiCycnXz[Y5k\SCxZjCyOUB1dyB{NUCgdG0hMC1rLXzvcYFqfmm2aXPpckBC	NFX1V\|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{G3O\|gzPid-MkexO\|c5OjZ:L3G+
SJ-GBM2	NX;Tc3ByeUiWUzDhd5NigQ>?			NIjnZ5VyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1qtS2JOOiClZXzsdy=>	NX\ubHYxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
SK-N-MC	NEPaUXZyUFSVIHHzd4F6			M2K3bpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSz3OMW1EKGOnbHzz	M3n6OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
MDCK	NVHMO5lHS3m2b4TvfIlkcXS7IHHzd4F6	NX\yNJhbPTByIH7N	NEL6UXgyKGi{	MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBOTEONIHPlcIx{KGW6cILld5NqdmdiY3HyZo9vcWNiYX7ofYRz[XOnIEmgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGG2IEWwNEBvVSCycnX0doVifGWmIH\vdkAyKGi{IH\vcIxwf2WmIHL5JFIhT3liaYLyZYRq[XSrb36geY5l\XJibn;ycY95cWNiY3;u[Il1cW:wIHL5JGFt[W2jcjDicJVmKGG\|c3H5	NED3NFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{iyN\|g4QSd-Mke4NlM5Pzl:L3G+
MDCK	NVLjeIh4S3m2b4TvfIlkcXS7IHHzd4F6	MWi1NFAhdk1?	Mn7JNUBpeg>?	NIT0TWxEgXSxdH;4bYNqfHliYXfhbY5{fCCPRFPLJINmdGy\|IHX4dJJme3OrbnegZ4Fz[m:waXOgZY5pgWS{YYPlJFkh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHH0JFUxOCCwTTDwdoV1emWjdHXkJIZweiBzIHjyJIZwdGyxd3XkJIJ6KDRiR4mgbZJz[WSrYYTpc44hfW6mZYKgZY5wgGmlIHPvcoRqfGmxbjDifUBCdGGvYYKgZox2\SCjc4PhfS=>	NFXXfXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{iyN\|g4QSd-Mke4NlM5Pzl:L3G+
MDCK	NF6zeYxEgXSxdH;4bYNqfHliYYPzZZk>	MnzuOVAxKG6P	NIr6T3Y4OiCqcoO=	NEHnUWFEgXSxdH;4bYNqfHliYXfhbY5{fCCPRFPLJINmdGy\|IHX4dJJme3OrbnegZ4Fz[m:waXOgZY5pgWS{YYPlJFkh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHH0JFUxOCCwTTDwdoV1emWjdHXkJIZweiB5MjDodpMh\m:ubH;3[YQh[nliN{KgbJJ{KGmwY4XiZZRqd25idX7k[ZIhdm:{bX;4bYMh[2:wZHn0bY9vKGK7IFHsZY1ieiCkbIXlJIF{e2G7	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzh{M{i3PUc,Ojd6MkO4O\|k9N2F-
MDCK	NGfkfZdEgXSxdH;4bYNqfHliYYPzZZk>	NEjCelc2ODBibl2=	MXm3NkBpenN?	NXvKW4VJS3m2b4TvfIlkcXS7IHHnZYlve3RiTVTDT{Bk\WyuczDlfJBz\XO\|aX7nJINiemKxbnnjJIFvcHmmcnHz[UA6KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDheEA2ODBibl2gZYZ1\XJiN{KgbJJ{KHWwZHXyJIFvd3irYzDjc45lcXSrb36gZpkhSWyjbXHyJIJtfWViYYPzZZk>	NHzJUZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{iyN\|g4QSd-Mke4NlM5Pzl:L3G+

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	E-cadherin / Vimentin / ZEB1 ; PubMed: 29157079 Cell Cycle Four kinds of cancer cells were treated with 5 μM VE-821 for 24 h and 48 h. The expression of E-cadherin, Vimentin and ZEB1 was performed by Western Blotting. Actin was used as loading control. Vimentin; PubMed: 29157079 Cell Cycle (D) MGC-803 cells were stained with antibodies to Vimentin (green) and nuclei was stained with DAPI. Images were captured by fluorescence microscopy at × 40 magnification. p-AKT / AKT / p-ERK / ERK ; PubMed: 29157079 Cell Cycle HCT-116 and NCI-N87 cells were added to 5 μM VE-821 for 24 h and 48 h. The total and phosphorylation expression of AKT and ERK was performed by Western Blotting.	29157079
Growth inhibition assay	Cell viability; PubMed: 29157079 Cell Cycle Indicated concentrations of VE-821 (0, 1, 5 and 10 μM) were added to four kinds of cancer cells (PANC-1, MGC-803, HCT-116 and NCI-N87) for 48 h. Cell viability was performed by MTT assay. Results from three independent experiments are shown.	29157079

激酶实验： ^[2]	- 合并激酶抑制实验: 使用放射性磷酸渗透实验测定化合物抑制ATR，ATM或DNAPK激酶活性的能力。制备包含适当缓冲液，激酶和靶点肽的储存液。向其中加入不同浓度溶于DMSO的可发生反应的化合物，DMSO终浓度为7％。加入适当的[γ-³³P]ATP溶液开始反应，在25°C下温育。经过所需的反应时间过程后，加入磷酸和ATP（终浓度分别为100 mM 和 0.66μM）终止实验。在磷酸纤维素膜上收集肽，使用200 μL 100 mM磷酸洗涤6次，然后加入100 μL闪烁混合液，在1450 Microbeta液体闪烁计数器上进行闪烁计数。使用GraphPad Prism软件进行剂量-反应数据分析。
细胞实验： ^[2]	- 合并 Cell lines: H2AX细胞 Concentrations: -- Incubation Time: 96小时 Method: 细胞接种在96孔板中，粘附过夜。第二天，加入指定浓度的化合物，终体积为200μL，细胞再温育96小时。然后加入MTS试剂(40μL)，1小时后，使用SpectraMax Plus 384酶标仪在490 nm处测量吸光度。使用Macsynergy软件评估协同作用和拮抗作用。 (Only for Reference)

参考文献

溶解度 (25°C)

体外	DMSO	74 mg/mL (200.86 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 30% PEG400+0.5% Tween80+5% propylene glycol	30 mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download VE-821 SDF

分子量	368.41
化学式	C₁₈H₁₆N₄O₃S
CAS号	1232410-49-9
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

ATM/ATR Signaling Pathway Map

ATM/ATR Inhibitors with Unique Features

泛ATM/ATR抑制剂

CGK 733 : Dual ATM/ATR inhibitor, IC50=~200 nM.
活性最高的ATM/ATR抑制剂

AZ20 ^New : ATR, IC50=5 nM.
用于临床的ATM/ATR抑制剂

BEZ235 (NVP-BEZ235, Dactolisib) : Phase II for Advanced Endometrial Carcinoma.
最新的ATM/ATR抑制剂

VE-822 ^New : ATR inhibitor with IC50 of 19 nM.

研究领域

产品类型

定制您的化合物库

VE-821

客户使用Selleck生产的VE-821发表文献164篇：

产品安全说明书

ATM/ATR抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download VE-821 SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

技术支持

ATM/ATR Signaling Pathway Map

ATM/ATR Inhibitors with Unique Features

相关ATM/ATR产品