SB202190 (FHPI)

For research use only. Not for use in humans.

目录号:S1077

SB202190 (FHPI) Chemical Structure

CAS No. 152121-30-7

SB202190 (FHPI)是一种有效的p38 MAPK抑制剂,靶向作用于p38α/β,无细胞试验中IC50为50 nM/100 nM,有时用于代替SB 203580研究其在体内对SAPK2a/p38的潜在作用。SB202190 可通过诱导自噬和血红素氧化酶1来抑制内皮细胞的凋亡。SB202190可显著抑制Erastin依赖的铁死亡ferroptosis

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1091.41 现货
RMB 1189.49 现货
RMB 3017.14 现货
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客户使用Selleck生产的SB202190 (FHPI)发表文献110篇:

产品安全说明书

p38 MAPK抑制剂选择性比较

生物活性

产品描述 SB202190 (FHPI)是一种有效的p38 MAPK抑制剂,靶向作用于p38α/β,无细胞试验中IC50为50 nM/100 nM,有时用于代替SB 203580研究其在体内对SAPK2a/p38的潜在作用。SB202190 可通过诱导自噬和血红素氧化酶1来抑制内皮细胞的凋亡。SB202190可显著抑制Erastin依赖的铁死亡ferroptosis
特性 SB 202190 与SB 203580极为相似。
靶点
Ferroptosis [11]
()
p38α [1]
(Cell-free assay)
p38β [1]
(Cell-free assay)
50 nM 100 nM
体外研究

SB 202190显著抑制内源本底和和抗Fas抗体诱导的MAPKAPK 2活性,且抑制效果呈剂量依赖性。SB 202190本身就足以诱导Jurkat细胞和Hela细胞的死亡:通过激活CPP 32样半胱氨酸蛋白酶,可阻断Bcl - 2的表达。p38β可减轻而p38α可加剧由SB 202190诱导的细胞凋亡[2]。在HaCaT细胞中SB 202190强烈抑制由紫外线诱导的cox - 2蛋白表达和 mRNA水平[3]。用SB 202190处理肾小管上皮细胞(正常大鼠k肝脏-52E),可将由白蛋白引发的炎症(单核细胞趋化蛋白-1,MCP - 1)或肿瘤生长因子β-1(TGFβ-1)引发的原纤维化(原骨胶原I a1,procollagen-i alpha1)相关基因降低50%[4]。SB 202190处理A549细胞,可诱导JNK磷酸化(该磷酸化效应呈时间和剂量依赖性)、转录因子ATF - 2磷酸化,并增加AP – 1与DNA的结合[6]。SB 202190处理促进THP-1和MV4-11细胞的生长。SB 202190可提高c-Raf 和ERK(细胞外信号调节激酶)磷酸化,暗示由SB 202190诱导的白血病细胞增殖过程有Ras-Raf-MEK-mitogen激活的MAPK通路的参与[7]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HCT-116 NFTBXmRHfW6ldHnvckBCe3OjeR?= Ml[5NlUh|ryP MYWzNEBucW5? MVrEUXNQyqB? M2DlUYF1fGWwdXH0[ZMhfGinIH3SUmEh[W6mIIDyc5RmcW5iZYjwdoV{e2mxbjDv[kBpSkRvMjDpckBz\XOyb37zbZZmKHSxIFTB MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ{M{K1NUc,OjZ{MkOyOVE9N2F-
MDA-MB-231 MlvRSpVv[3Srb36gRZN{[Xl? NH\Te48zKM7:TR?= NWThWllSOjRiaB?= M2niV4xme3OnbnXzJGNEVDJiaX7keYN1cW:wIHL5JHRPTs7z MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjFyMEi0PEc,OjZzMEC4OFg9N2F-
rBMSCs MV\GeY5kfGmxbjDBd5NigQ>? NXvsc5pLOTBizszN Mo\MNk42KGh? NVzYfJVs\GWycnXzd4V{KHSqZTDwbI9{eGixconsZZRqd25ib3[gSXJMKGGwZDDwN|g> MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB3M{K2Okc,OjZyNUOyOlY9N2F-
MG63 NFvCWG9HfW6ldHnvckBCe3OjeR?= NIPwe2YyOC9{MD:zNEDPxE1? M1TPZ|I1KGh? NIHQPZV{cWewaX\pZ4FvfGy7IHTlZ5Jm[XOnczD0bIUhdGW4ZXygc4YheGixc4Doc5J6dGG2ZXSgdFM5KGmwZIXj[YQh[nliQ3TDcFIhcW5iYTDjc45k\W62cnH0bY9vKC2mZYDlcoRmdnRibXHucoVz NV\yXJB7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5PVg{OTJpPkK1PVk5OzF{PD;hQi=>
MG63 MlnVRZBweHSxc3nzJGF{e2G7 M{HuclExNzJyL{OwJO69VQ>? M1jVRVI1KGh? NGTqUmN{cWewaX\pZ4FvfGy7IHTlZ5Jm[XOnZDD0bIUh[XCxcITvd4l{KHKjdHWgc4YhVUd4MzDpcoR2[2WmIHL5JGNlS2x{ NHnmV3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUm5PFMyOid-MkW5PVg{OTJ:L3G+
HTSMCs MnKxSpVv[3Srb36gRZN{[Xl? MWGwMlEwOS9zMDFOwG0> NEfGZ3AyKGh? MX3pcohq[mm2ZXSgR29TVS1{LXnu[JVk\WRiSF:tNUBxem:2ZXnuJIxmfmWuczDhcoQhdVKQQTDlfJBz\XO|aX;u NWnYfGpMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5NlE1PjRpPkK1PVIyPDZ2PD;hQi=>
MIA PaCa-2 NXn2ZVR7TnWwY4Tpc44hSXO|YYm= NFfqWokzOMLizszN M2LJVlI1KGh? MkPBdoVlfWOnZDDsZYN1[XSnIHHjZ5VufWyjdHnvckBqdiClb33ibY5ifGmxbjD3bZRpKGKxdHigNk1FTyCjbnSgSE1idGyxc3ZCpC=> M{\DNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEi4OFg6Lz5{NUi4PFQ5QTxxYU6=
MIA PaCa-2 NF7xZ3BHfW6ldHnvckBCe3OjeR?= NVPOT|lROjEEoN88US=> M{nqeFI1KGh? MmLodoV{fWy2czDpckBiKG2xZHXzeEBqdmirYnn0bY9vKG:oIFjJSk0y|rFicILveIVqdiCjY3P1cZVt[XSrb36= NEDqW5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi4PFQ5QSd-MkW4PFg1QDl:L3G+
BxPC-3 NWLrbpAxTnWwY4Tpc44hSXO|YYm= MYeyNOKh|ryP MnHCNlQhcA>? NVXSNmFvemW|dXz0d{BqdiCjIH3v[IV{fCCrbnjpZol1cW:wIH;mJGhKTi1zzsGgdJJwfGWrbjDhZ4N2dXWuYYTpc44> M4DHXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEi4OFg6Lz5{NUi4PFQ5QTxxYU6=
AsPC-1 NVXPTmhWTnWwY4Tpc44hSXO|YYm= NIP0[3IzOMLizszN M4r1XVI1KGh? NYjPTJZ7emW|dXz0d{BqdiCjIH3v[IV{fCCrbnjpZol1cW:wIH;mJGhKTi1zzsGgdJJwfGWrbjDhZ4N2dXWuYYTpc44> NYOzcFBPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4PFg1QDlpPkK1PFg5PDh7PD;hQi=>
MIA PaCa-2 M{PJcmZ2dmO2aX;uJGF{e2G7 MVKyNOKh|ryP MnzCNlQhcA>? MYnlcohidmOnczDjcIVifmGpZTDv[kBRSVKSIIfo[Y4h[2:vYnnu[YQhf2m2aDDncJVkd3OnIHHuZYxw\3N? NXr1OGhzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4PFg1QDlpPkK1PFg5PDh7PD;hQi=>
MIA PaCa-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPIVIkzOMLizszN NV\qV2dROiCq Mk\3d4Vve2m2aYrld{Bk\WyuIHzpcoV{KHSxIITy[YF1dWWwdDD3bZRpKDJvRFegZY5lKERvYXzsc5Nm NU\5TIl{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4PFg1QDlpPkK1PFg5PDh7PD;hQi=>
BxPC-3 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjmRlczOMLizszN NFnsflQzKGh? M3jFZ5NmdnOrdHn6[ZMh[2WubDDsbY5meyC2bzD0doVifG2nboSge4l1cCB{LVTHJIFv\CCGLXHscI9{\Q>? NYTTSpN1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4PFg1QDlpPkK1PFg5PDh7PD;hQi=>
AsPC-1 NYG3bmdpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlraNlDDqM7:TR?= MmXINkBp NU\kVpVue2Wwc3n0bZpmeyClZXzsJIxqdmW|IITvJJRz\WG2bXXueEB4cXSqIEKtSGch[W6mIFStZYxtd3On MnPJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6OEi0PFkoRjJ3OEi4OFg6RC:jPh?=
HEY MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXiyNOKh|ryP NWTvfFRzOiCq NWnaXpc2e2Wwc3n0bZpmeyClZXzsJIxqdmW|IITvJJRz\WG2bXXueEB4cXSqIEKtSGch[W6mIFStZYxtd3On NGLPRpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi4PFQ5QSd-MkW4PFg1QDl:L3G+
OVCAR-3 NXHqeYF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILLN|gzOMLizszN M1njSlIhcA>? NW\aXYlbe2Wwc3n0bZpmeyClZXzsJIxqdmW|IITvJJRz\WG2bXXueEB4cXSqIEKtSGch[W6mIFStZYxtd3On NHK5OmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi4PFQ5QSd-MkW4PFg1QDl:L3G+
SK-OV-3 M4j3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jIRlIxyqEQvF2= MomwNkBp NHrjWpJ{\W6|aYTpfoV{KGOnbHygcIlv\XNidH:geJJm[XSvZX70JJdqfGhiMj3ES{BidmRiRD3hcIxwe2V? NHrmSVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi4PFQ5QSd-MkW4PFg1QDl:L3G+
MH7A  M3Sxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVOyOEBp M3q2[pJmcW6ob4Lj[ZMhfGinIHnubIljcXSxcomg[YZn\WO2czDv[kBZSU5? MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh4Mkm2Okc,OjV6NkK5OlY9N2F-
MH7A  NF3p[I5CeG:ydH;zbZMhSXO|YYm= NFT1cGszPSEQvF2= NXf3d2JSOjRiaB?= NVry[ZZjemW4ZYLz[ZMh[2WubDDjfYNt\SCjcoLld5QhcW6mdXPl[EBjgSC[QV6gZY5lKGOjdYPl[EBieG:ydH;zbZMhd2ZiY3XscJMhfmmjIHHjeIl3[XSrb36gc4YhUk6N MoDLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6NkK5OlYoRjJ3OE[yPVY3RC:jPh?=
SCC25 Mmr1SpVv[3Srb36gRZN{[Xl? NWr4UJBpOjBizszN M3zPXlI1KGh? MkjrbY5kemWjc3XzJIF2fG:yaHHnfUBt\X[nbB?= NHm4WG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUizOFQxOCd-MkW4N|Q1ODB:L3G+
HaCaT  NULMNm57TnWwY4Tpc44hSXO|YYm= MkDpOUDDvU1? M{XqN|I1KGh? MULpcohq[mm2czDJSm4u|rNvaX7keYNm\CCFQ1yyNkBxem:mdXP0bY9vKGyndnXsdy=> NVuxPWdxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4N|Q{PTNpPkK1PFM1OzV|PD;hQi=>
HaCaT  M{jHXmZ2dmO2aX;uJGF{e2G7 NV;XenJ[PSEEtV2= NEHNeIYzPCCq M{XoN4lvcGmkaYTzJGlHVi4QsT3pcoR2[2WmIFPDUFIzKHC{b3T1Z5Rqd25ibHX2[Yx{ NV3KboZkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4N|Q{PTNpPkK1PFM1OzV|PD;hQi=>
HPAEpiCs  NGHpPFBHfW6ldHnvckBCe3OjeR?= NXzTe3RlOS9|L{GwJO69VQ>? MmC1NUBp MVLy[YR2[2W|IGOxVE1qdmS3Y3XkJGlESU1vMTDwdo91\WmwIHHu[EBuWk6DIHX4dJJme3Orb36gZY5lKHC{b33veIVzKGGldHn2bZR6 MonEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5M{S5NFAoRjJ3N{O0PVAxRC:jPh?=
HPAEpiCs M1:3WGZ2dmO2aX;uJGF{e2G7 M4DGWVEwOy9zMDFOwG0> MX:xJIg> M4TseIlvcGmkaYTzJHMyWC2|dHnteYxifGWmIFHreEBxcG:|cHjvdplt[XSrb36gJOKh NW\6c|RjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3N|Q6ODBpPkK1O|M1QTByPD;hQi=>
HPAEpiCs MmPXSpVv[3Srb36gRZN{[Xl? Mo[5NU8{NzFyIN88US=> MYKxJIg> NH75eYlqdmirYnn0d{BUOVBidHnt[U1l\XCnbnTlcpRtgSC|dHnteYxifGWmIHOtTpVvKHCqb4PwbI9zgWyjdHnvci=> NXH1dINRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3N|Q6ODBpPkK1O|M1QTByPD;hQi=>
K562 M4m3fmZ2dmO2aX;uJGF{e2G7 MnTjNVDDqM7:TR?= MlT4NeKhcA>? M1jSe2ROW09? Ml3JbY5pcWKrdIOgdZVqdmGlcnnu[U1qdmS3Y3XkJJA{QCCPQWDLJJBpd3OyaH;yfYxifGmxbh?= NUHxPJdIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PFQxPDNpPkK1Olg1ODR|PD;hQi=>
PANC-1 NYjEZ4Z6TnWwY4Tpc44hSXO|YYm= M3TtR|ExKM7:TR?= NY\6d29bOSCq M4XteIVvcGGwY3XzJJRp\SCjdYTvdIhi\2mlIHXm[oVkfMLi NWDZcFZ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2N|IzOjJpPkK1OlMzOjJ{PD;hQi=>
BxPC-3 M{frfGZ2dmO2aX;uJGF{e2G7 M{\IRVExKM7:TR?= NVnqfFdrOSCq Mluz[Y5p[W6lZYOgeIhmKGG3dH;wbIFocWNiZX\m[YN1yqB? NWjOS|VDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2N|IzOjJpPkK1OlMzOjJ{PD;hQi=>
K562  NGL1OIhHfW6ldHnvckBCe3OjeR?= NYqy[WtiOC5{NT2xJO69VQ>? MXuyOEBp NHL6bpp{fXCycnXzd4V{KHKnc4\ldoF1em:uLXnu[JVk\WRiSELBXEBxcG:|cHjvdplt[XSrb36= NUjaRnRZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2NVk{QTJpPkK1OlE6Ozl{PD;hQi=>
THP-1 NUDkO4lyTnWwY4Tpc44hSXO|YYm= NF;vTFM2KML3TR?= NGL2TXgzKGh? NHPIUWd{cWewaX\pZ4FvfGy7IHH0eIVvfWG2ZYOgd4VkemW2aX;uJI9nKEmOLUJOtUBqdmS3Y3XkJIJ6KDJ5T1jDbI9tKHCudYOgSnNNNTIEoB?= NGGzOJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUW5PFY3OSd-MkW1PVg3PjF:L3G+
WB MYDGeY5kfGmxbjDBd5NigQ>? NWDHNo1jOjEkgJpOwG3DqA>? MVWzNQKBkW2rbh?= MnHM[IVkemWjc3XzJJRp\SCOUGOtJI9zKEyWQT3pcoR2[2WmIFnMMVYh[W6mIGTOSk3PucLicILv[JVkfGmxbh?= M3G3bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUOwOlgzLz5{NUWzNFY5OjxxYU6=
RAW 264.7 NF71eIRHfW6ldHnvckBCe3OjeR?= NIXlcXQyOMLizszN NEHLXYM{OOLCiX3pci=> M2T2dolv\HWlZYOgZ4hiemGldHXybZN1cWNidnHjeY9t[XSrb36gc4YhV0O|wrC= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR4MUO5PUc,OjV2NkGzPVk9N2F-
RAW 264.7 M2P0[2Z2dmO2aX;uJGF{e2G7 NFnmT4wyOMLizszN NYfJ[WJXOzEkgJntbY4> NEfwRVlifHSnboXheIV{KHSqZTDl[oZm[3S|IH;mJG9RTyCxbjDvd5Rmd2OuYYP0JJJmfHKjY4Tpc44> NWXoOmNmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0OlE{QTlpPkK1OFYyOzl7PD;hQi=>
HaCaT  NUfVPIdJTnWwY4Tpc44hSXO|YYm= MVq0NOKh|ryP MoHXN{0zPCCq NHHSZVZFVVOR MWHy[YR2[2W|IITo[UBi[2O3bYXsZZRqd25ib3[gXm8uOQ>? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR|NUS4OUc,OjV2M{W0PFU9N2F-
H9c2 MX;GeY5kfGmxbjDBd5NigQ>? NY\kSJFpPTEEoN88UeKh Mlv3NVIhcA>? NU\5RmRremWmdXPld{BNTEhicnXs[YF{\SCjbnSgUW1RKGyxc4O= NHXmUZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK0OVgyQCd-MkWyOFU5OTh:L3G+
HSCs M1nqNmFxd3C2b4Ppd{BCe3OjeR?= Mlq5NlUh|ryP NVHTS5R[OjUEoHi= NVzhOXZYe2mpbnnmbYNidnSueTDheJRmdnWjdHXzJHRINWmwZIXj[YQh[WO2aY\heIVlKEiVQ4OgZZBweHSxc3nz NX\vR4luRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OlE6PTBpPkK0PVYyQTVyPD;hQi=>
THP-1 NHHtcXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPxUZc4OiCq NWjpdGNNTE2VTx?= M4fIdWlEPTB;ND63{txO M2j5NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEG1NFg4Lz5{NEixOVA5PzxxYU6=
MDDCs NF25eYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnH6O|IhcA>? MojmSG1UVw>? MXXJR|UxOi55zszN MknBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6MUWwPFcoRjJ2OEG1NFg4RC:jPh?=
MDDCs NU\zS|RLTnWwY4Tpc44hSXO|YYm= NU\XZ5AzOC1zNTFOwG0> Mmn5OFghcA>? NV6zeWxLTE2VTx?= NH;WWVF{fXCycnXzd4V{KEmITj5OtUBidmRiSWCtNVAheHKxZIXjeIlwdsLi NFTMVpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEixOVA5Pyd-MkS4NVUxQDd:L3G+
MDDCs M1PHPWZ2dmO2aX;uJGF{e2G7 M4nYOFAuOTVizszN Mm\rOFghcA>? M4XI[mROW09? NWHxOnI6cW6qaXLpeJMhVUmSLUHhMEBOUVBvMXKgZY5lKFKDTmTFV{Bxem:mdXP0bY9v NUGzR|lnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4NVUxQDdpPkK0PFE2ODh5PD;hQi=>
MDDCs M{TnUGZ2dmO2aX;uJGF{e2G7 MU[xNEDPxE1? MmS5N{42KGh? MUXEUXNQ MnzEZoxw[2u|IFXCU3YhT1BuIHL1eEBvd3RiVmPWJGchdWWmaXH0[YQh\W62comgbY51dyCqdX3hckBOTESFcx?= MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDhzNUC4O{c,OjR6MUWwPFc9N2F-
macrophages MXXGeY5kfGmxbjDBd5NigQ>? MYOx5qCK|ryP NWHEOIQ5PC534pEJbC=> NHjTOIJkd22ybHX0[Yx6KGmwaHnibZR{KE2WLVnJTU1qdmS3Y3XkJIFkfGm4YYTpc44hd2ZiTl[t{tpD NUnyTZBCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4NFg3OzNpPkK0PFA5PjN|PD;hQi=>
PDL  NEKxeHZHfW6ldHnvckBCe3OjeR?= MWKyNOKh|ryPwrC= NHTqbYo{OCCvaX6= M4XhemROW09? MWLzbYdvcW[rY3HueIx6KGmwaHnibZR{KHSqZTD0[Y5{cWynIH\vdoNmNW2nZHnheIVlKEKPUD2yJIV5eHKnc4Ppc44> MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV4MUC4NUc,OjR3NkGwPFE9N2F-
AGS NUX5SZkxTnWwY4Tpc44hSXO|YYm= NUO5VWpRPSEQvF2= NX65b416OzBibXnu M3\5d5N2eHC{ZYPz[ZPDqDFvaX7keYNm\CClYYPwZZNmNThiYX7kJINie3Cjc3WtN{Bi[3SrdnH0bY9v M4HrVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUS3PFc5Lz5{NEW0O|g4QDxxYU6=
H520 M1jxVWZ2dmO2aX;uJGF{e2G7 NEH1eo4yOMLiwsXN M{[4SVEhcA>? MXLEUXNQ NGD3[nNl\WO{ZXHz[ZMhfGinIIDlcYV1emW6ZXStbY5lfWOnZDDNV2gzKG2UTlGgZY5lKHC{b4TlbY4hdGW4ZXzz NFXsTFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWzNFQ4PSd-MkS1N|A1PzV:L3G+
H1703 MnjKSpVv[3Srb36gRZN{[Xl? NInBZ|AyOMLiwsXN MkPtNUBp NVv2T5h2TE2VTx?= NWXVNGpH\GWlcnXhd4V{KHSqZTDw[Y1mfHKneHXkMYlv\HWlZXSgUXNJOiCvUl7BJIFv\CCycn;0[YlvKGyndnXsdy=> MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV|MES3OUc,OjR3M{C0O|U9N2F-
H520 MXHGeY5kfGmxbjDBd5NigQ>? MYexNOKhyrWP Mlu1NVIhcA>? NH3yZ|ZFVVOR MVTpcohq[mm2czDw[Y1mfHKneHXkMYVtcWOrdHXkJG1UUDJicILveIVqdiC|dHHibYxqfHl? NEnGeVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWzNFQ4PSd-MkS1N|A1PzV:L3G+
H1703 MoX2SpVv[3Srb36gRZN{[Xl? MX:xNOKhyrWP NYL3Onp7OTJiaB?= MWXEUXNQ M2TldIlvcGmkaYTzJJBmdWW2cnX4[YQu\WyrY3n0[YQhVVOKMjDwdo91\WmwIIP0ZYJqdGm2eR?= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV|MES3OUc,OjR3M{C0O|U9N2F-
H520 NHj6UVBHfW6ldHnvckBCe3OjeR?= NVT2d4JiOTEEoNM1US=> NIP3cpc3KGh? NYm2VlNlTE2VTx?= NHzK[Xl{cWewaX\pZ4FvfGy7IHnuZ5Jm[XOnczD0bIUhdGW4ZXzzJI9nKHWkaYH1bZRqdi2lb37qeYdifGWmIF3TTFIhcW5icHXt[ZRz\XinZD30doVifGWmwrDj[YxtKGyrbnW= NWLWc45GRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1N|A1PzVpPkK0OVMxPDd3PD;hQi=>
H1703 NX;4ZXl{TnWwY4Tpc44hSXO|YYm= NV7mUoljOTEEoNM1US=> NYnk[pFnPiCq NWPzWoZYTE2VTx?= NXq5dGw3e2mpbnnmbYNidnSueTDpcoNz\WG|ZYOgeIhmKGyndnXsd{Bw\iC3YnnxeYl1cW5vY3;ubpVo[XSnZDDNV2gzKGmwIIDlcYV1emW6ZXSteJJm[XSnZNMgZ4VtdCCuaX7l M1fyVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUOwOFc2Lz5{NEWzNFQ4PTxxYU6=
MC3T3-E1 M1LDfGZ2dmO2aX;uJGF{e2G7 MVuwMlMwOy9|MDFOwG0> NYTxboROOSCq M{TwWYF1fGWwdXH0[ZMhXE6ILd8xMYlv\HWlZXSgUW1RNTliZYjwdoV{e2mxbjDpckBiKGOxbnPlcpRz[XSrb36t[IVx\W6mZX70JI1idm6nctMg MmH4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MEK2PVYoRjJ2NUCyOlk3RC:jPh?=
MC3T3-E1 NIHMU49HfW6ldHnvckBCe3OjeR?= MUmzNEDPxE1? MkjrNUBp NYjVS4hF[XS2ZX71ZZRmeyCWTl[t{tEue3SrbYXsZZRm\CCyM{igUWFRUyCyaH;zdIhwenmuYYTpc44> MoHKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MEK2PVYoRjJ2NUCyOlk3RC:jPh?=
HUVECs  NYPRcGs5TnWwY4Tpc44hSXO|YYm= NXfVdGtrOTEEoNM1US=> NUG2XYc5OSCq MlqwbY5pcWKrdIOgWG5HNc7zLXnu[JVk\WRiQ2jDUFEheHKxZIXjeIlwdg>? NY[w[VljRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0PFc6PjRpPkK0OFg4QTZ2PD;hQi=>
AGS  NXyyRW15TnWwY4Tpc44hSXO|YYm= NYTBSWZIOTEEoNM1US=> NHnZOpU{OMLibXnu MmfnbY5pcWKrdIOgTWwuOc7{LXnu[JVk\WRiYXP0bZZifGmxbjDv[kBxOzh? Mn\LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2N{m2PFEoRjJ2NEe5OlgyRC:jPh?=
MKN-45 NU\oOZZpTnWwY4Tpc44hSXO|YYm= NHjSeYcyOMLiwsXN NVzJZYQ{OzEEoH3pci=> Mkf6bY5pcWKrdIOgTWwuOc7{LXnu[JVk\WRiYXP0bZZifGmxbjDv[kBxOzh? MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR5OU[4NUc,OjR2N{m2PFE9N2F-
AGS  M1:zb2Z2dmO2aX;uJGF{e2G7 NFPMToMyOMLiwsXN MYWzNOKhdWmw NF3wSIdifHSnboXheIV{KEmOLUJOtk1qdmS3Y3XkJGdCKGOnbHygcYloemG2aX;uJIFv\CCrbo\hd4lwdg>? MnvMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2N{m2PFEoRjJ2NEe5OlgyRC:jPh?=
MKN-45 M4TGcWZ2dmO2aX;uJGF{e2G7 M{HSSVExyqEEtV2= MYezNOKhdWmw MXHheJRmdnWjdHXzJGlNNTIQsj3pcoR2[2WmIFfBJINmdGxibXnndoF1cW:wIHHu[EBqdn[jc3nvci=> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR5OU[4NUc,OjR2N{m2PFE9N2F-
AGS  MVvGeY5kfGmxbjDBd5NigQ>? NWfabI9IOTEEoNM1US=> MkHFN|DDqG2rbh?= NV3SdGpse2mpbnnmbYNidnSueTDk[YNz\WG|ZYOgTYwuOc7{LXnu[JVk\WRiTV3QNkBidmRiTV3QPUBuWk6DIHX4dJJme3Orb36= MorFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2N{m2PFEoRjJ2NEe5OlgyRC:jPh?=
MKN-45 MUHGeY5kfGmxbjDBd5NigQ>? M{nrW|ExyqEEtV2= Mn7QN|DDqG2rbh?= MUHzbYdvcW[rY3HueIx6KGSnY4LlZZNmeyCLbD2x{tIucW6mdXPl[EBOVVB{IHHu[EBOVVB7IH3SUmEh\XiycnXzd4lwdg>? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR5OU[4NUc,OjR2N{m2PFE9N2F-
DCs M{T4bWZ2dmO2aX;uJGF{e2G7 MlGxNlDDqM7:TR?= MV[xxsBp Mnfy[IVkemWjc3XzJGlNNTF{IIDyc4R2[3Srb36= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR|NE[zOkc,OjR2M{S2N|Y9N2F-
HUVEC  M{jOW2Z2dmO2aX;uJGF{e2G7 MlPONlAh|ryvwrC= M1XaOVUhcA>? MXrEUXNQ Ml7GdoVlfWOnczDjfZRwc2mwZTDlfJBz\XO|aX;uJIxmfmWuczDpckBiKGOxbnPlcpRz[XSrb36t[IVx\W6mZX70JI1idm6nch?= NY\LVHlZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxPFkxPjJpPkK0NVg6ODZ{PD;hQi=>
A 549 Ml25SpVv[3Srb36gRZN{[Xl? NXH3dFNEPTBizszN NW\KRlhjOSCq NVm2NHBO\GWlcnXhd4V{KHSqZTDs[ZZmdCCxZjDJUE05yqB? M2nyUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUe5Olg5Lz5{NEG3PVY5QDxxYU6=
H520  MlzvSpVv[3Srb36gRZN{[Xl? NWP3bJN7PS9zMDFOwG0> NF\KU4kyKGh? MmfsSG1UVw>? MmLC[IVkemWjc3XzJG1UUDJicILveIVqdiCjczD3[YxtKGG|IH3SUmEhdGW4ZXzzJIlvKGenZnn0bY5q[i2neIDvd4VlKGOnbHy= NIHCOFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGzPFkxOyd-MkSxN|g6ODN:L3G+
H1703  MUDGeY5kfGmxbjDBd5NigQ>? Mmq2OU8yOCEQvF2= M1TySVEhcA>? NWrCT2NCTE2VTx?= M37JV4Rm[3KnYYPld{BOW0h{IIDyc5RmcW5iYYOge4VtdCCjczDtVm5CKGyndnXsd{BqdiCpZX\peIlvcWJvZYjwc5Nm\CClZXzs MonqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzM{i5NFMoRjJ2MUO4PVA{RC:jPh?=
H520  NWTmbG5HTnWwY4Tpc44hSXO|YYm= MkKyNVDDqML3TR?= NGnLSZYyOiCq NU\Veng2TE2VTx?= M{H0UYRm[3KnYYPld{BOW0h{IH3SUmEh[W6mIIDyc5RmcW5ic4ThZoltcXS7IHnuJIdm\mm2aX7pZk11emWjdHXkJG5US0yFIHPlcIx{ NVW3fYZuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxN|g6ODNpPkK0NVM5QTB|PD;hQi=>
H1703  Ml;FSpVv[3Srb36gRZN{[Xl? MU[xNOKhyrWP NVT3XnFGOTJiaB?= Ml7ISG1UVw>? MYXk[YNz\WG|ZYOgUXNJOiCvUl7BJIFv\CCycn;0[YlvKHO2YXLpcIl1gSCrbjDn[YZqfGmwaXKteJJm[XSnZDDOV2NNSyClZXzsdy=> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF|OEmwN{c,OjRzM{i5NFM9N2F-
MCF-7  MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\CVnkyOMLizszN Ml7lNlTDqGh? NYfwPWRZcW6qaXLpeJMhfGinIFPSNVA5NWmwZIXj[YQh[2WubDDk[YF1cA>? NWLVOVA4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxNlg5PTNpPkK0NVI5QDV|PD;hQi=>
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podocytes NYfHb4pFTnWwY4Tpc44hSXO|YYm= MWexNOKh|ryP MkPMNUBp MknIbY5pcWKrdIOgWGdH|rJzLXnu[JVk\WRiYXP0bZZifGmxbjDv[kBxOziPQWDLJIFv\CCHcnuxM|LDqA>? MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB|NkKxNkc,OjRyM{[yNVI9N2F-
MCF-7 MnrFSpVv[3Srb36gRZN{[Xl? M3PS[|ExyqEQvF2= MnvYNUBp MWXEUXNQ Ml30doVlfWOnczD0bIUhX0FvaX7keYNm\CCyaH;zdIhwenmuYYTl[EBxOzhiTVHQTy=> NH;i[o09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECxPVA6OCd-MkSwNVkxQTB:L3G+
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H1650  NWe2fHZ{TnWwY4Tpc44hSXO|YYm= M2XybFExyqEQvF5CpC=> NW\QWXg5OSCq M2rKV2ROW09? NFK5R21l\WO{ZXHz[ZMh[m:2aDDwdo91\WmwIHHu[EBuWk6DIHzleoVteyCxZjDFVmNEOSCrbjDwZYNtcXSjeHXsMYV5eG:|ZXVCpINmdGy| MnzXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{Mki2PVYoRjJ|MkK4Olk3RC:jPh?=
H1703 MlfFSpVv[3Srb36gRZN{[Xl? NG\GOJUyOMLizszNxsA> MnG2NUBp MXTEUXNQ MYTk[YNz\WG|ZYOgZo91cCCycn;0[YlvKGGwZDDtVm5CKGyndnXsd{Bw\iCHUlPDNUBqdiCyYXPsbZRigGWuLXX4dI9{\WUEoHPlcIx{ NIHo[HQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{KyPFY6Pid-MkOyNlg3QTZ:L3G+
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medulloblastoma cells MlLCRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MnPJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCvZXT1cIxw[myjc4TvcYEh[2WubIOgbIFz[m:{aX7nJIhmfGW{b4r5[492eyCydHPoNUBo\W6nIHL5JG1VXCCjc4PhfUwhTUN3MDC9JFMvODB4IN88UU4> M4DXdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG3OlMyLz5zN{SxO|Y{OTxxYU6=
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RAW264.7 Mn75SpVv[3Srb36gZZN{[Xl? NEXTZYRRem:2ZXP0bY9vKGGpYXnud5QhSmGlaXzseZMh[W62aILhZ4l{KHC{b4TlZ5RqfmViYX70bYdmdiCjbnSgcIV1cGGuIITvfIlvNWSrcHj0bIVzcWFidH;4bY4h[2irbXXybYMheHKxdHXpckBu\WSrYYTl[EBkgXSxdH;4bYNqfHliaX6gcY92e2ViUlHXNlY1NjdiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJk> NInBb2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S4OVUxPCd-MUe0PFU2ODR:L3G+
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SJ-GBM2 NXXJXnp5eUiWUzDhd5NigQ>? M3e4epFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHNLNUeETUKgZ4VtdHN? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
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... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
mTOR / p-S6K / S6K / p-S6 / p-AKT / p-MK2; 

PubMed: 26844273     


CRC cells were treated with 10 μM SB202190 for 2 h and analyzed for mTOR signaling and on-target inhibition of p38 by immunoblot. 

pJNK1 / pJNK2 / JNK1 / JNK2 ; 

PubMed: 18222647     


A549 cells were treated with DMSO control or with 10 µM of SB202190 for 0.5, 1, 2, 3, 4, or 6 hours, and pJNK and unphosphorylated JNK were detected as described. 

26844273 18222647
Immunofluorescence
p-p38 / MMP9; 

PubMed: 24479681     


Immunocytochemical staining and confocal microscopy confirmed that IL-1β increased activation of p38 (red), and MMP2 and MMP9 (green) expression in MKN-45 GA cells; these effects were blocked by p38 siRNA or the p38 inhibitor SB202190.

24479681
Growth inhibition assay
Cell viability ; 

PubMed: 26844273     


Top panel: CRC cells were treated with various concentrations of SB202190 for 48 h. Lower panel: CRC cells were treated with SB202190 at 10 μM for different times. Cell growth was measured by SRB assay (means ± s.d. in triplet, n = 3 in triplet).

26844273
体内研究

SB 202190通过抑制p38减弱了由人脊髓灰质炎IgG(PV-IgG)在被动转移小鼠模型中诱发的水泡形成[5]。在脓毒症内毒素模型中,与对照组相比,经SB 202190处理可显著提高存活率[8]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

体外酶活检测:

p38α 和 p38β 溶解在25mM的Tris - HCl缓冲液中,PH 7.5,含0.1mM EGTA,髓鞘碱性蛋白(0.33毫克/毫升)作为底物。人工操作条件用50μL [γ-33P]ATP于30 °C孵育10分钟;Biomek 2000自动化工作站用25μL [γ-33P]ATP在96孔板室温孵育40分钟。ATP和乙酸镁浓度分别为0.1mM和10mM。所有检测都用MgATP起始。人工检测将孵育液滴到磷酸纤维素纸上,浸泡在50mM磷酸中。用5μL磷酸终止反应,后将孵育液点滴在P30过滤垫上。滤膜在50mM磷酸中漂洗四次以去除ATP,在用丙酮(人工孵育)或甲醇(工作站孵育)处理后,干燥并用放射性计量。
细胞实验:

[2]

- 合并
  • Cell lines: Jurkat, 和 HeLa细胞
  • Concentrations: 溶解于DMSO, 终浓度~50 μM
  • Incubation Time: 24 小时
  • Method:

    细胞血清饥饿后,用不同浓度SB 202190处理24小时。用台盼蓝或PI染色后经流式细胞仪分析,以检测细胞活力。凋亡细胞核用H33258染色。


    (Only for Reference)
动物实验:

[5]

- 合并
  • Animal Models: C57BL/6J 小鼠皮内注射无菌的对照IgG或人脊髓灰质炎IgG做对比。
  • Dosages: 12.5 μg
  • Administration: 皮内注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 66 mg/mL (199.19 mM)
Ethanol 12 mg/mL (36.21 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5%DMSO+40%PEG300+5%Tween80+50%H2O
8 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 331.34
化学式

C20H14N3OF

CAS号 152121-30-7
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

p38 MAPK Signaling Pathway Map

p38 MAPK Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID