SB202190 (FHPI)

For research use only. Not for use in humans.

目录号:S1077

SB202190 (FHPI) Chemical Structure

CAS No. 152121-30-7

SB202190 (FHPI)是一种有效的p38 MAPK抑制剂,靶向作用于p38α/β,无细胞试验中IC50为50 nM/100 nM,有时用于代替SB 203580研究其在体内对SAPK2a/p38的潜在作用。SB202190 可通过诱导自噬和血红素氧化酶1来抑制内皮细胞的凋亡。SB202190可显著抑制Erastin依赖的铁死亡ferroptosis

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1091.41 现货
RMB 1189.49 现货
RMB 3017.14 现货
有超大折扣

今日订购,明日送达,全国免运费!

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的SB202190 (FHPI)发表文献122篇:

产品安全说明书

p38 MAPK抑制剂选择性比较

生物活性

产品描述 SB202190 (FHPI)是一种有效的p38 MAPK抑制剂,靶向作用于p38α/β,无细胞试验中IC50为50 nM/100 nM,有时用于代替SB 203580研究其在体内对SAPK2a/p38的潜在作用。SB202190 可通过诱导自噬和血红素氧化酶1来抑制内皮细胞的凋亡。SB202190可显著抑制Erastin依赖的铁死亡ferroptosis
特性 SB 202190 与SB 203580极为相似。
靶点
Ferroptosis [11]
()
p38α [1]
(Cell-free assay)
p38β [1]
(Cell-free assay)
50 nM 100 nM
体外研究

SB 202190显著抑制内源本底和和抗Fas抗体诱导的MAPKAPK 2活性,且抑制效果呈剂量依赖性。SB 202190本身就足以诱导Jurkat细胞和Hela细胞的死亡:通过激活CPP 32样半胱氨酸蛋白酶,可阻断Bcl - 2的表达。p38β可减轻而p38α可加剧由SB 202190诱导的细胞凋亡[2]。在HaCaT细胞中SB 202190强烈抑制由紫外线诱导的cox - 2蛋白表达和 mRNA水平[3]。用SB 202190处理肾小管上皮细胞(正常大鼠k肝脏-52E),可将由白蛋白引发的炎症(单核细胞趋化蛋白-1,MCP - 1)或肿瘤生长因子β-1(TGFβ-1)引发的原纤维化(原骨胶原I a1,procollagen-i alpha1)相关基因降低50%[4]。SB 202190处理A549细胞,可诱导JNK磷酸化(该磷酸化效应呈时间和剂量依赖性)、转录因子ATF - 2磷酸化,并增加AP – 1与DNA的结合[6]。SB 202190处理促进THP-1和MV4-11细胞的生长。SB 202190可提高c-Raf 和ERK(细胞外信号调节激酶)磷酸化,暗示由SB 202190诱导的白血病细胞增殖过程有Ras-Raf-MEK-mitogen激活的MAPK通路的参与[7]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HCT-116 MXTGeY5kfGmxbjDBd5NigQ>? M{HtNFI2KM7:TR?= M4LmfVMxKG2rbh?= NWPHTJczTE2VT9Mg M3Xw[IF1fGWwdXH0[ZMhfGinIH3SUmEh[W6mIIDyc5RmcW5iZYjwdoV{e2mxbjDv[kBpSkRvMjDpckBz\XOyb37zbZZmKHSxIFTB NH7UO3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkKyN|I2OSd-Mk[yNlMzPTF:L3G+
MDA-MB-231 MUDGeY5kfGmxbjDBd5NigQ>? NXHNW3FQOiEQvF2= NILjfGozPCCq MUDs[ZN{\W6nczDDR2wzKGmwZIXjeIlwdiCkeTDUUmbPuQ>? MknPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzMEC4OFgoRjJ4MUCwPFQ5RC:jPh?=
rBMSCs MVnGeY5kfGmxbjDBd5NigQ>? MUOxNEDPxE1? Mn3FNk42KGh? Mnnj[IVxemW|c3XzJJRp\SCyaH;zdIhwenmuYYTpc44hd2ZiRWLLJIFv\CCyM{i= Mn;VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyNUOyOlYoRjJ4MEWzNlY3RC:jPh?=
MG63 MXrGeY5kfGmxbjDBd5NigQ>? NWPDOIx2OTBxMkCvN|Ah|ryP NWjpRlBsOjRiaB?= NGH6SWt{cWewaX\pZ4FvfGy7IHTlZ5Jm[XOnczD0bIUhdGW4ZXygc4YheGixc4Doc5J6dGG2ZXSgdFM5KGmwZIXj[YQh[nliQ3TDcFIhcW5iYTDjc45k\W62cnH0bY9vKC2mZYDlcoRmdnRibXHucoVz Mni1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7OUizNVIoRjJ3OUm4N|EzRC:jPh?=
MG63 NXnBRVgxSXCxcITvd4l{KEG|c3H5 MXSxNE8zOC9|MDFOwG0> MXKyOEBp M3L3ZZNq\26rZnnjZY51dHliZHXjdoVie2WmIITo[UBieG:ydH;zbZMhemG2ZTDv[kBOTzZ|IHnu[JVk\WRiYomgR4REdDJ? M3nVcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUm4N|EzLz5{NUm5PFMyOjxxYU6=
HTSMCs MVrGeY5kfGmxbjDBd5NigQ>? M1jaOlAvOS9zL{GwJO69VQ>? MXqxJIg> MXHpcohq[mm2ZXSgR29TVS1{LXnu[JVk\WRiSF:tNUBxem:2ZXnuJIxmfmWuczDhcoQhdVKQQTDlfJBz\XO|aX;u MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl{MUS2OEc,OjV7MkG0OlQ9N2F-
MIA PaCa-2 NGHtdWxHfW6ldHnvckBCe3OjeR?= NX7qOYxJOjEEoN88US=> NXfBXIM6OjRiaB?= NHHXXnFz\WS3Y3XkJIxi[3SjdHWgZYNkfW23bHH0bY9vKGmwIHPvcYJqdmG2aX;uJJdqfGhiYn;0bEAzNUSJIHHu[EBFNWGubH;z[eKh MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh6OES4PUc,OjV6OEi0PFk9N2F-
MIA PaCa-2 M2nhWWZ2dmO2aX;uJGF{e2G7 M1z3W|IxyqEQvF2= M{CxN|I1KGh? NWnkeVJZemW|dXz0d{BqdiCjIH3v[IV{fCCrbnjpZol1cW:wIH;mJGhKTi1zzsGgdJJwfGWrbjDhZ4N2dXWuYYTpc44> NVjSfFBDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4PFg1QDlpPkK1PFg5PDh7PD;hQi=>
BxPC-3 M2WwPWZ2dmO2aX;uJGF{e2G7 NX;1N3d6OjEEoN88US=> NVXQV2U{OjRiaB?= NFrGbZpz\XO3bITzJIlvKGFibX;k[ZN1KGmwaHnibZRqd25ib3[gTGlHNTIQsTDwdo91\WmwIHHjZ5VufWyjdHnvci=> NWHNTGNGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4PFg1QDlpPkK1PFg5PDh7PD;hQi=>
AsPC-1 M2D4W2Z2dmO2aX;uJGF{e2G7 NFrhcoozOMLizszN MVmyOEBp MWXy[ZN2dHS|IHnuJIEhdW:mZYP0JIlvcGmkaYTpc44hd2ZiSFnGMVHPuSCycn;0[YlvKGGlY4XteYxifGmxbh?= NH7WTWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi4PFQ5QSd-MkW4PFg1QDl:L3G+
MIA PaCa-2 MknYSpVv[3Srb36gRZN{[Xl? NUDyelY2OjEEoN88US=> MYOyOEBp NHHnZWFmdmijbnPld{BkdGWjdnHn[UBw\iCSQWLQJJdp\W5iY3;tZolv\WRid3n0bEBodHWlb4PlJIFv[WyxZ4O= MmLSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6OEi0PFkoRjJ3OEi4OFg6RC:jPh?=
MIA PaCa-2 M4jMZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2ru[|IxyqEQvF2= MWqyJIg> NHjSbVR{\W6|aYTpfoV{KGOnbHygcIlv\XNidH:geJJm[XSvZX70JJdqfGhiMj3ES{BidmRiRD3hcIxwe2V? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh6OES4PUc,OjV6OEi0PFk9N2F-
BxPC-3 MniwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLKNlDDqM7:TR?= MWSyJIg> MlTEd4Vve2m2aYrld{Bk\WyuIHzpcoV{KHSxIITy[YF1dWWwdDD3bZRpKDJvRFegZY5lKERvYXzsc5Nm Mn7zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6OEi0PFkoRjJ3OEi4OFg6RC:jPh?=
AsPC-1 NFmwc4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFH1[FMzOMLizszN NGLlOG4zKGh? NVS2XWRze2Wwc3n0bZpmeyClZXzsJIxqdmW|IITvJJRz\WG2bXXueEB4cXSqIEKtSGch[W6mIFStZYxtd3On NIr2fJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi4PFQ5QSd-MkW4PFg1QDl:L3G+
HEY MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnntNlDDqM7:TR?= M{mxNVIhcA>? M3\we5NmdnOrdHn6[ZMh[2WubDDsbY5meyC2bzD0doVifG2nboSge4l1cCB{LVTHJIFv\CCGLXHscI9{\Q>? NWLXU3hRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4PFg1QDlpPkK1PFg5PDh7PD;hQi=>
OVCAR-3 NYLoOXRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfxSmUzOMLizszN MYKyJIg> NF;0Xph{\W6|aYTpfoV{KGOnbHygcIlv\XNidH:geJJm[XSvZX70JJdqfGhiMj3ES{BidmRiRD3hcIxwe2V? NWXLfnlyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4PFg1QDlpPkK1PFg5PDh7PD;hQi=>
SK-OV-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPZNlDDqM7:TR?= NGPE[owzKGh? M{HaR5NmdnOrdHn6[ZMh[2WubDDsbY5meyC2bzD0doVifG2nboSge4l1cCB{LVTHJIFv\CCGLXHscI9{\Q>? NXjNSI9NRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4PFg1QDlpPkK1PFg5PDh7PD;hQi=>
MH7A  NWDRc5c4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLUNlQhcA>? NY\aWYgzemWrbn\vdoNmeyC2aHWgbY5pcWKrdH;yfUBm\m[nY4TzJI9nKFiDTh?= MoO3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6NkK5OlYoRjJ3OE[yPVY3RC:jPh?=
MH7A  MoTyRZBweHSxc3nzJGF{e2G7 Ml;oNlUh|ryP NVHRcHN3OjRiaB?= MUHy[ZZmenOnczDj[YxtKGO7Y3zlJIFzemW|dDDpcoR2[2WmIHL5JHhCViCjbnSgZ4F2e2WmIHHwc5B1d3OrczDv[kBk\WyuczD2bYEh[WO2aY\heIlwdiCxZjDKUms> Ml\NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6NkK5OlYoRjJ3OE[yPVY3RC:jPh?=
SCC25 NFLuWnlHfW6ldHnvckBCe3OjeR?= Ml3BNlAh|ryP M1\PbFI1KGh? M4HEO4lv[3KnYYPld{BifXSxcHjh[5khdGW4ZXy= M4nEWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEO0OFAxLz5{NUizOFQxODxxYU6=
HaCaT  M{LaW2Z2dmO2aX;uJGF{e2G7 NVvLfJFXPSEEtV2= NU\mb3pwOjRiaB?= NG\RRmtqdmirYnn0d{BKTk5vzsOtbY5lfWOnZDDDR2wzOiCycn;keYN1cW:wIHzleoVtew>? MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh|NEO1N{c,OjV6M{SzOVM9N2F-
HaCaT  NES4fIZHfW6ldHnvckBCe3OjeR?= NXvnOpFJPSEEtV2= NH3pVIgzPCCq MUHpcohq[mm2czDJSm4u|rFvaX7keYNm\CCFQ1yyNkBxem:mdXP0bY9vKGyndnXsdy=> M1r3WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEO0N|U{Lz5{NUizOFM2OzxxYU6=
HPAEpiCs  M{HHVGZ2dmO2aX;uJGF{e2G7 MWmxM|MwOTBizszN M3vaVlEhcA>? NFLkZ2Zz\WS3Y3XzJHMyWC2rbnT1Z4VlKEmFQV2tNUBxem:2ZXnuJIFv\CCvUl7BJIV5eHKnc4Ppc44h[W6mIIDyc41wfGW{IHHjeIl3cXS7 NFnKT3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUezOFkxOCd-MkW3N|Q6ODB:L3G+
HPAEpiCs Mki3SpVv[3Srb36gRZN{[Xl? NVfjbYNDOS9|L{GwJO69VQ>? NUL5[VZJOSCq MmTMbY5pcWKrdIOgV|FRNXO2aX31cIF1\WRiQXv0JJBpd3OyaH;yfYxifGmxbjCgxsA> NXrweZN5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3N|Q6ODBpPkK1O|M1QTByPD;hQi=>
HPAEpiCs NX[y[lN2TnWwY4Tpc44hSXO|YYm= NEPqfpUyNzNxMUCg{txO M2HJXVEhcA>? NH7i[JZqdmirYnn0d{BUOVBidHnt[U1l\XCnbnTlcpRtgSC|dHnteYxifGWmIHOtTpVvKHCqb4PwbI9zgWyjdHnvci=> MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd|NEmwNEc,OjV5M{S5NFA9N2F-
K562 NFzxSoRHfW6ldHnvckBCe3OjeR?= MXKxNOKh|ryP NI[wc4YyyqCq M17W[GROW09? Mlu1bY5pcWKrdIOgdZVqdmGlcnnu[U1qdmS3Y3XkJJA{QCCPQWDLJJBpd3OyaH;yfYxifGmxbh?= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6NEC0N{c,OjV4OESwOFM9N2F-
PANC-1 M{L0ZmZ2dmO2aX;uJGF{e2G7 NXj3RoNrOTBizszN NVfWRnYyOSCq M3fSfIVvcGGwY3XzJJRp\SCjdYTvdIhi\2mlIHXm[oVkfMLi MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ|MkKyNkc,OjV4M{KyNlI9N2F-
BxPC-3 MXzGeY5kfGmxbjDBd5NigQ>? MorHNVAh|ryP NEfjd2cyKGh? Moex[Y5p[W6lZYOgeIhmKGG3dH;wbIFocWNiZX\m[YN1yqB? NFfieWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[zNlIzOid-MkW2N|IzOjJ:L3G+
K562  NIixfVFHfW6ldHnvckBCe3OjeR?= MVOwMlI2NTFizszN NW\QXYF3OjRiaB?= NHjiWGJ{fXCycnXzd4V{KHKnc4\ldoF1em:uLXnu[JVk\WRiSELBXEBxcG:|cHjvdplt[XSrb36= MmrwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4MUmzPVIoRjJ3NkG5N|kzRC:jPh?=
THP-1 NGrhXVZHfW6ldHnvckBCe3OjeR?= M3rzVVUhyrWP MmXlNkBp MWPzbYdvcW[rY3HueIx6KGG2dHXueYF1\XNic3XjdoV1cW:wIH;mJGlNNTIQsTDpcoR2[2WmIHL5JFI4V0iFaH;sJJBtfXNiRmPMMVHDqA>? M2DmflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUm4OlYyLz5{NUW5PFY3OTxxYU6=
WB Mlu2SpVv[3Srb36gRZN{[Xl? M{H4SVIx6oDLzszNxsA> MXGzNQKBkW2rbh?= M4GzcYRm[3KnYYPld{B1cGViTGDTMUBweiCOVFGtbY5lfWOnZDDJUE03KGGwZDDUUmYu|rIEoIDyc4R2[3Srb36= NWTzdm15RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1N|A3QDJpPkK1OVMxPjh{PD;hQi=>
RAW 264.7 NVm5VpF7TnWwY4Tpc44hSXO|YYm= M{nQelExyqEQvF2= MUizNQKBkW2rbh?= NYnlV4VCcW6mdXPld{BkcGG{YXP0[ZJqe3SrYzD2ZYN2d2yjdHnvckBw\iCRQ4RCpC=> NWHCbnRzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0OlE{QTlpPkK1OFYyOzl7PD;hQi=>
RAW 264.7 NYfFWG41TnWwY4Tpc44hSXO|YYm= MmnqNVDDqM7:TR?= NYnFdoZSOzEkgJntbY4> NXjFe4hn[XS2ZX71ZZRmeyC2aHWg[YZn\WO2czDv[kBQWEdib36gc5N1\W:lbHHzeEBz\XS{YXP0bY9v NIrsOHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS2NVM6QSd-MkW0OlE{QTl:L3G+
HaCaT  NYHCeplwTnWwY4Tpc44hSXO|YYm= NYLTU4hmPDEEoN88US=> MmDVN{0zPCCq MlK4SG1UVw>? MoT6doVlfWOnczD0bIUh[WOldX31cIF1cW:wIH;mJHpQNTF? NXfyTI9sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0N|U1QDVpPkK1OFM2PDh3PD;hQi=>
H9c2 NGDTSopHfW6ldHnvckBCe3OjeR?= MWm1NOKh|ryPwrC= M2nKV|EzKGh? M13FbpJm\HWlZYOgUGRJKHKnbHXhd4Uh[W6mIF3NVEBtd3O| NHi5WJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK0OVgyQCd-MkWyOFU5OTh:L3G+
HSCs NHfmS2tCeG:ydH;zbZMhSXO|YYm= M3HnOVI2KM7:TR?= M17IUlI1yqCq MVTzbYdvcW[rY3HueIx6KGG2dHXueYF1\XNiVFetbY5lfWOnZDDhZ5RqfmG2ZXSgTHNEeyCjcH;weI9{cXN? M{TQVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OU[xPVUxLz5{NEm2NVk2ODxxYU6=
THP-1 Mk\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWe3NkBp NWnKXW16TE2VTx?= M3LtSmlEPTB;ND63{txO M{jneVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEG1NFg4Lz5{NEixOVA5PzxxYU6=
MDDCs MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DI[|czKGh? NYT0VnV5TE2VTx?= NV3vTnNsUUN3MEKuO:69VQ>? NYnpSJpLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4NVUxQDdpPkK0PFE2ODh5PD;hQi=>
MDDCs MkGzSpVv[3Srb36gRZN{[Xl? NHrVWnAxNTF3IN88US=> NEjQXFQ1QCCq M{LzTGROW09? M{LQS5N2eHC{ZYPz[ZMhUU[QLd8xJIFv\CCLUD2xNEBxem:mdXP0bY9vyqB? NU\YelR6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4NVUxQDdpPkK0PFE2ODh5PD;hQi=>
MDDCs MlHYSpVv[3Srb36gRZN{[Xl? MWWwMVE2KM7:TR?= NVPZeVlqPDhiaB?= NY\pPFc1TE2VTx?= MlnabY5pcWKrdIOgUWlRNTGjLDDNTXAuOWJiYX7kJHJCVlSHUzDwdo9lfWO2aX;u MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDhzNUC4O{c,OjR6MUWwPFc9N2F-
MDDCs M{K2NWZ2dmO2aX;uJGF{e2G7 NGDoOIcyOCEQvF2= NW\Qdo1YOy53IHi= NILo[2VFVVOR MUjicI9kc3NiRVLPWkBIWCxiYoX0JI5wfCCYU2[gS{Bu\WSrYYTl[EBmdnS{eTDpcpRwKGi3bXHuJG1FTEO| Mn7aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6MUWwPFcoRjJ2OEG1NFg4RC:jPh?=
macrophages MUXGeY5kfGmxbjDBd5NigQ>? MU[x5qCK|ryP MW[0MlXjiImq M{nSR4NwdXCuZYTlcJkhcW6qaXLpeJMhVVRvSVnJMYlv\HWlZXSgZYN1cX[jdHnvckBw\iCQRj5OvmI> MlXXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6MEi2N|MoRjJ2OEC4OlM{RC:jPh?=
PDL  M3foUGZ2dmO2aX;uJGF{e2G7 NY\tdZhoOjEEoN88UeKh M3LWT|MxKG2rbh?= MmL2SG1UVw>? Mkj1d4lodmmoaXPhcpRtgSCrbnjpZol1eyC2aHWgeIVve2muZTDmc5Jk\S2vZXTpZZRm\CCETWCtNkBmgHC{ZYPzbY9v MoHjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3NkGwPFEoRjJ2NU[xNFgyRC:jPh?=
AGS MlHISpVv[3Srb36gRZN{[Xl? Ml3KOUDPxE1? NGfyOY4{OCCvaX6= NYLPUZVje3WycILld5Nme8LiMT3pcoR2[2WmIHPhd5Bie2VvODDhcoQh[2G|cHHz[U0{KGGldHn2ZZRqd25? MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV2N{i3PEc,OjR3NEe4O|g9N2F-
H520 MorFSpVv[3Srb36gRZN{[Xl? NUPteYtqOTEEoNM1US=> NXPzU5RjOSCq MYjEUXNQ MWjk[YNz\WG|ZYOgeIhmKHCnbXX0doV5\WRvaX7keYNm\CCPU1iyJI1TVkFiYX7kJJBzd3SnaX6gcIV3\Wy| NGPyU4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWzNFQ4PSd-MkS1N|A1PzV:L3G+
H1703 NX7VW|VVTnWwY4Tpc44hSXO|YYm= NH;1PVcyOMLiwsXN MmPYNUBp MX3EUXNQ MYfk[YNz\WG|ZYOgeIhmKHCnbXX0doV5\WRvaX7keYNm\CCPU1iyJI1TVkFiYX7kJJBzd3SnaX6gcIV3\Wy| NGXSSVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWzNFQ4PSd-MkS1N|A1PzV:L3G+
H520 NHvCe4ZHfW6ldHnvckBCe3OjeR?= MlT1NVDDqML3TR?= MojJNVIhcA>? M4rnTmROW09? NULiSYhvcW6qaXLpeJMheGWvZYTy[Zhm\C2nbHnjbZRm\CCPU1iyJJBzd3SnaX6gd5Ri[mmuaYT5 NIrNcJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWzNFQ4PSd-MkS1N|A1PzV:L3G+
H1703 NX7CW49tTnWwY4Tpc44hSXO|YYm= M130N|ExyqEEtV2= M3f3VFEzKGh? NEnhXoJFVVOR M1;rVYlvcGmkaYTzJJBmdWW2cnX4[YQu\WyrY3n0[YQhVVOKMjDwdo91\WmwIIP0ZYJqdGm2eR?= MoT1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3M{C0O|UoRjJ2NUOwOFc2RC:jPh?=
H520 NUP5S4hDTnWwY4Tpc44hSXO|YYm= NYTIfm9nOTEEoNM1US=> MYC2JIg> MVjEUXNQ NGC0dpZ{cWewaX\pZ4FvfGy7IHnuZ5Jm[XOnczD0bIUhdGW4ZXzzJI9nKHWkaYH1bZRqdi2lb37qeYdifGWmIF3TTFIhcW5icHXt[ZRz\XinZD30doVifGWmwrDj[YxtKGyrbnW= NYH2OI5ZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1N|A1PzVpPkK0OVMxPDd3PD;hQi=>
H1703 NEC1S5RHfW6ldHnvckBCe3OjeR?= NGrTUJYyOMLiwsXN NYHnNYU3PiCq MUjEUXNQ Mlzrd4lodmmoaXPhcpRtgSCrbnPy[YF{\XNidHjlJIxmfmWuczDv[kB2[mmzdXn0bY4u[2:waoXnZZRm\CCPU1iyJIlvKHCnbXX0doV5\WRvdILlZZRm\MLiY3XscEBtcW6n M162S|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUOwOFc2Lz5{NEWzNFQ4PTxxYU6=
MC3T3-E1 NEPhU2ZHfW6ldHnvckBCe3OjeR?= M1XqVlAvOy9|L{OwJO69VQ>? MoXiNUBp NW\yRW1E[XS2ZX71ZZRmeyCWTl[t{tEucW6mdXPl[EBOVVBvOTDlfJBz\XO|aX;uJIlvKGFiY3;uZ4VvfHKjdHnvck1l\XCnbnTlcpQhdWGwbnXyxsA> MlzrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MEK2PVYoRjJ2NUCyOlk3RC:jPh?=
MC3T3-E1 MnfnSpVv[3Srb36gRZN{[Xl? M3\yWVMxKM7:TR?= MVOxJIg> MlX3ZZR1\W63YYTld{BVVkZvzsGtd5RqdXWuYYTl[EBxOzhiTVHQT{BxcG:|cHjvdplt[XSrb36= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDVyMk[5Okc,OjR3MEK2PVY9N2F-
HUVECs  MWLGeY5kfGmxbjDBd5NigQ>? M3ztU|ExyqEEtV2= NEXZWmwyKGh? NF7TeJZqdmirYnn0d{BVVkZvzsGtbY5lfWOnZDDDXGNNOSCycn;keYN1cW:w M172eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEi3PVY1Lz5{NES4O|k3PDxxYU6=
AGS  Ml\NSpVv[3Srb36gRZN{[Xl? Mn\BNVDDqML3TR?= M4e4UlMxyqCvaX6= MV7pcohq[mm2czDJUE0y|rJvaX7keYNm\CCjY4TpeoF1cW:wIH;mJJA{QA>? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR5OU[4NUc,OjR2N{m2PFE9N2F-
MKN-45 M3jVbGZ2dmO2aX;uJGF{e2G7 MXexNOKhyrWP M4HuRVMxyqCvaX6= M1;U[IlvcGmkaYTzJGlNNTIQsj3pcoR2[2WmIHHjeIl3[XSrb36gc4YheDN6 MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR5OU[4NUc,OjR2N{m2PFE9N2F-
AGS  M37CZmZ2dmO2aX;uJGF{e2G7 NF\aR5cyOMLiwsXN NHTwdW4{OMLibXnu NHrBPIxifHSnboXheIV{KEmOLUJOtk1qdmS3Y3XkJGdCKGOnbHygcYloemG2aX;uJIFv\CCrbo\hd4lwdg>? NXrSc3RHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0O|k3QDFpPkK0OFc6PjhzPD;hQi=>
MKN-45 NX3HRndDTnWwY4Tpc44hSXO|YYm= NITkVIwyOMLiwsXN NHXw[Wk{OMLibXnu M131dIF1fGWwdXH0[ZMhUUxvMd8yMYlv\HWlZXSgS2Eh[2WubDDtbYdz[XSrb36gZY5lKGmwdnHzbY9v NV7hOYFqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0O|k3QDFpPkK0OFc6PjhzPD;hQi=>
AGS  M4Xt[WZ2dmO2aX;uJGF{e2G7 MUOxNOKhyrWP M3e3b|MxyqCvaX6= NHzLblN{cWewaX\pZ4FvfGy7IHTlZ5Jm[XOnczDJcE0y|rJvaX7keYNm\CCPTWCyJIFv\CCPTWC5JI1TVkFiZYjwdoV{e2mxbh?= MlrsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2N{m2PFEoRjJ2NEe5OlgyRC:jPh?=
MKN-45 MV7GeY5kfGmxbjDBd5NigQ>? NWLCVW12OTEEoNM1US=> M4TFNlMxyqCvaX6= NFriXld{cWewaX\pZ4FvfGy7IHTlZ5Jm[XOnczDJcE0y|rJvaX7keYNm\CCPTWCyJIFv\CCPTWC5JI1TVkFiZYjwdoV{e2mxbh?= M{\6UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEe5OlgyLz5{NES3PVY5OTxxYU6=
DCs M2C1O2Z2dmO2aX;uJGF{e2G7 NUjs[XpFOjEEoN88US=> MmDJNeKhcA>? NYi1NIlF\GWlcnXhd4V{KEmOLUGyJJBzd2S3Y4Tpc44> MnK3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2M{S2N|YoRjJ2NEO0OlM3RC:jPh?=
HUVEC  MXnGeY5kfGmxbjDBd5NigQ>? MX[yNEDPxG4EoB?= NEXzbI42KGh? MkHHSG1UVw>? M3[3bZJm\HWlZYOgZ5l1d2urbnWg[ZhxemW|c3nvckBt\X[nbIOgbY4h[SClb37j[Y51emG2aX;uMYRmeGWwZHXueEBu[W6wZYK= NF\uWZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEG4PVA3Oid-MkSxPFkxPjJ:L3G+
A 549 MoW4SpVv[3Srb36gRZN{[Xl? Mo\BOVAh|ryP MXuxJIg> NHTYWZdl\WO{ZXHz[ZMhfGinIHzleoVtKG:oIFnMMVjDqA>? M2PTNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUe5Olg5Lz5{NEG3PVY5QDxxYU6=
H520  MoHBSpVv[3Srb36gRZN{[Xl? NU[1c5N1PS9zMDFOwG0> MWSxJIg> NVrOV|ZUTE2VTx?= M4LjVoRm[3KnYYPld{BOW0h{IIDyc5RmcW5iYYOge4VtdCCjczDtVm5CKGyndnXsd{BqdiCpZX\peIlvcWJvZYjwc5Nm\CClZXzs M3mxPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUO4PVA{Lz5{NEGzPFkxOzxxYU6=
H1703  M3K4RmZ2dmO2aX;uJGF{e2G7 MmnqOU8yOCEQvF2= NHrVZ28yKGh? NV\ZXpZnTE2VTx?= NW\T[VE5\GWlcnXhd4V{KE2VSEKgdJJwfGWrbjDhd{B4\WyuIHHzJI1TVkFibHX2[Yx{KGmwIHfl[ol1cW6rYj3lfJBwe2WmIHPlcIw> NYr0eVNnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxN|g6ODNpPkK0NVM5QTB|PD;hQi=>
H520  NWjt[GdpTnWwY4Tpc44hSXO|YYm= NGLJcZoyOMLiwsXN M{fwTVEzKGh? NHTRVVRFVVOR M4C2UoRm[3KnYYPld{BOW0h{IH3SUmEh[W6mIIDyc5RmcW5ic4ThZoltcXS7IHnuJIdm\mm2aX7pZk11emWjdHXkJG5US0yFIHPlcIx{ MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF|OEmwN{c,OjRzM{i5NFM9N2F-
H1703  MkHFSpVv[3Srb36gRZN{[Xl? MWWxNOKhyrWP MlmzNVIhcA>? NVXDd5pvTE2VTx?= M3WwSoRm[3KnYYPld{BOW0h{IH3SUmEh[W6mIIDyc5RmcW5ic4ThZoltcXS7IHnuJIdm\mm2aX7pZk11emWjdHXkJG5US0yFIHPlcIx{ M1q2dFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUO4PVA{Lz5{NEGzPFkxOzxxYU6=
MCF-7  MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUixNOKh|ryP MlPaNlTDqGh? NWPxW2F6cW6qaXLpeJMhfGinIFPSNVA5NWmwZIXj[YQh[2WubDDk[YF1cA>? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF{OEi1N{c,OjRzMki4OVM9N2F-
HPAEpiCs NEHGUnpHfW6ldHnvckBCe3OjeR?= NXnTVVlROC5zL{GvNVAh|ryP MomyNUBp NF7SenZqdmirYnn0d{BVVkZvzsGtbY5lfWOnZDDjVGxCOsLicILveIVqdiCjbnSgcXJPSSCneIDy[ZN{cW:w MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB4OUG1PEc,OjRyNkmxOVg9N2F-
podocytes MX\GeY5kfGmxbjDBd5NigQ>? NXjiN2NsOTEEoN88US=> MkPINUBp NVvmbGZMcW6qaXLpeJMhXEeIzsKxMYlv\HWlZXSgZYN1cX[jdHnvckBw\iCyM{jNRXBMKGGwZDDFdosyNzMEoB?= MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB|NkKxNkc,OjRyM{[yNVI9N2F-
MCF-7 MonmSpVv[3Srb36gRZN{[Xl? MWGxNOKh|ryP MnrDNUBp Mn:zSG1UVw>? M4nGWpJm\HWlZYOgeIhmKFeDLXnu[JVk\WRicHjvd5Bpd3K7bHH0[YQheDN6IF3BVGs> M2XONVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEG5NFkxLz5{NECxPVA6ODxxYU6=
MCF-7 M{G2PGZ2dmO2aX;uJGF{e2G7 M1m1elExyqEQvF2= M2nkclI1KGh? MWnEUXNQ NYXYRppucW6lcnXhd4V{KHSqZTDXRU1qdmS3Y3XkJIFxd3C2b4Ppdy=> MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDBzOUC5NEc,OjRyMUmwPVA9N2F-
HAPI M1\0VWZ2dmO2aX;uJGF{e2G7 NHz5[5AyOC9{MD:0NOKh|ryP NYWxSZk6OSCq MXzpcohq[mm2czDUR2RFNWmwZIXj[YQheDN6L1rOT{BOSVCNIIDoc5NxcG:{eXzheIlwdg>? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4OUGyNEc,OjN7NkmxNlA9N2F-
HAPI M4TXOWZ2dmO2aX;uJGF{e2G7 MVeyNOKh|ryPwrC= M4nYW|EhcA>? NXzHXG5ZTE2VTx?= MofrZZR1\W63YYTld{BVS0SGLXnu[JVk\WRiYXP0bZZifGmxbjDv[kBqVk:VIHHu[EBxem:mdXP0bY9v NGrjNnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2PVEzOCd-MkO5OlkyOjB:L3G+
HepG2 NFLxUm1HfW6ldHnvckBCe3OjeR?= NEK2Zlg{PTBibl2= Mn;vNlQhcA>? NUPWNWQ{cW6qaXLpeJMhfGinIHTl[5VmdGmwLXnu[JVk\WRiYXP0bZZifGmxbjDv[kBxOziPQWDL NFfIPZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mzN|E6QCd-MkO5N|MyQTh:L3G+
AGS  NF:xSlFHfW6ldHnvckBCe3OjeR?= M4\uUlExyqEQvF2= NILmRnc{OCCvaX6= MUHpcohq[mm2czDjZZNx[XOnLUOgZYN1cX[jdHnvckBidmRiaX7obYJqfGmxbjDv[kBGWkt? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh3MEm5OEc,OjN6NUC5PVQ9N2F-
HepG2 M1G1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUf0V5VkOC13MDFOwG0> NFy5eVM1QCCq Mlf5bY5pcWKrdIOgeIhmKHC{b3zp[oVz[XSrb36gbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhyN{WwPEc,OjN6MEe1NFg9N2F-
BEL7404 Mo\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MViwMVUxKM7:TR?= NVzMRVh{PDhiaB?= NV7MOnl6cW6qaXLpeJMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZI> NYDzdoE6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NFc2ODhpPkKzPFA4PTB6PD;hQi=>
HL7702 MojUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWSwMVUxKM7:TR?= MXe0PEBp MW\pcohq[mm2czD0bIUheHKxbHnm[ZJifGmxbjDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= NG\JZYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iwO|UxQCd-MkO4NFc2ODh:L3G+
HepG2 NHn3d41HfW6ldHnvckBCe3OjeR?= NGfR[IkxNTVyIN88US=> M3rX[FI1KGh? MVvpcohq[mm2czD0bIUheGixc4Doc5J6dGG2aX;uJI9nKHB|ODDkc5dve3S{ZXHtJJBzd3SnaX7zJG1CWEuDUFuyMEBCXEZ{LDDNV2syKGGwZDDIV3AzPyCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? M{TtdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEC3OVA5Lz5{M{iwO|UxQDxxYU6=
BEAS-2B M3m3WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\Dd5BEOTBizszN Mn7sN|AhdWmw M3HPT5JmfmW{c3XzJJRp\SCmZXPy[YF{\SCxZjDj[YxtKH[rYXLpcIl1gSCrbnT1Z4VlKGK7IFjDTS=> NG\Q[nI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e4OFA{PCd-MkO3PFQxOzR:L3G+
BEAS-2B MYLDfZRwfG:6aYT5JGF{e2G7 MXixNEDPxE1? M3i5elMxKG2rbh?= MVfpcohq[mm2ZXSgeIhmKGmwY4LlZZNmKGmwIFzETEBidmRiSVytPEBmgHC{ZYPzbY9v MkjsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5OESwN|QoRjJ|N{i0NFM1RC:jPh?=
BEAS-2B MlzLSpVv[3Srb36gRZN{[Xl? MVGxNEDPxE1? NHeyN44{OCCvaX6= NHHDc|Fl\WO{ZXHz[ZMhfGinIHzleoVteyCxZjDjZZNx[XOnLUOsJGJi\CCjbnSg[oF{ MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd6NECzOEc,OjN5OESwN|Q9N2F-
H9c2  MmS4SpVv[3Srb36gRZN{[Xl? NYXtZXE5OC5yMT:wMlEwOSEQvF2= NUC5eY9HOSCq MW\heJRmdnWjdHXzJHRPTi4QsT3pcoR2[2WmIF3NVE06KGW6cILld5Nqd25uIH3SUmEhdGW4ZXzzMEBidmRicILvcY91\XJiYXP0bZZqfHl? Mn75QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5N{SyOVIoRjJ|N{e0NlUzRC:jPh?=
H9c2  M{PyR2Z2dmO2aX;uJGF{e2G7 MknENUDPxE1? MYixJIg> MVvy[YR2[2W|IGTOSk3PuSCmaYLlZ5RtgSC|dHnteYxifGWmIICzPEBOSVCNIIDoc5NxcG:{eXzheIlwdg>? NUPBcHZCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3O|QzPTJpPkKzO|c1OjV{PD;hQi=>
U937 NIjvSIJHfW6ldHnvckBCe3OjeR?= NVj5dmtXOTEEoN88UeKh M{n0e|EhcA>? NWX4OppP[WK{b3fheIV{KHSqZTDjZYZn\WmwZTDl[oZm[3Rib36gUWtRNTFiYX7kJHBROkGlzsGgcXJPSSC2cnHud4NzcXC2aX;uZYwhdGW4ZXzz NFfCWYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ewO|M5Pyd-MkO3NFc{QDd:L3G+
U937 MYLGeY5kfGmxbjDBd5NigQ>? NHP3d2cyOMLizszNxsA> NVXDfWhxOSCq NUH2VG1b[WK{b3fheIV{KGOjZn\lbY5mNWmwZIXj[YQhVUuSLUGg[I94di2{ZXf1cIF1cW:wIHHu[EBRWDKDY98xJJVxNXKnZ4XsZZRqd25? NUPYSoJYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3NFc{QDdpPkKzO|A4Ozh5PD;hQi=>
U937 Mn24SpVv[3Srb36gRZN{[Xl? M3zzfVExyqEQvF5CpC=> NH\Q[4wyKGh? Mlzhd5VxeHKnc4Pld{BkNUq3bjDhcoQhS1KHQjDwbI9{eGixconsZZRqd25iaX6gZ4Fn\mWrbnWteJJm[XSnZDDj[Yxte8Li MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzdyN{O4O{c,OjN5MEezPFc9N2F-
A549 MYDGeY5kfGmxbjDBd5NigQ>? MU[wMlMwOy9|MDFOwG0> NEjreVEyKGh? MYPzbYdvcW[rY3HueIx6KGG2dHXueYF1\XNiQWTQ{tNUNW2nZHnheIVlKEORWD2yJJBzd3SnaX6gZY5lKG2UTlGg[ZhxemW|c3nvckBidmRicILvcY91\XJiYXP0bZZqfHoEoB?= NEfBU|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[4NFY4PCd-MkO2PFA3PzR:L3G+
A549 MVrGeY5kfGmxbjDBd5NigQ>? M3\FdFExyqEQvF5CpC=> M2D3[VAuOzBibXnu M1TRRolvcGmkaYTzJGFVWM7|UzDpcoR2[2WmIIC0Nk9xPDRiTVHQT{BidmRicEO4JG1CWEticHjvd5Bpd3K7bHH0bY9v NFvzVHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[4NFY4PCd-MkO2PFA3PzR:L3G+
A549 NH3Re4NHfW6ldHnvckBCe3OjeR?= MUixNOKh|ryPwrC= MV2xJIg> NEK0N2FqdmirYnn0d{BCXFEQs2OgbY5lfWOnZDDOSk3PwkJicE[1JJN2[nWwaYSgdIhwe3Cqb4L5cIF1cW:wIHHu[EBPTi4QulKgdJJwdW:2ZYKgZYN1cX[rdIm= NXTPW4NWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2PFA3PzRpPkKzOlgxPjd2PD;hQi=>
A549 M1z1b2Z2dmO2aX;uJGF{e2G7 NIrIO3YyOMLizszNxsA> MYOxJIg> Mni5doVlfWOnczDBWHDPu1Nvc4TpcZVt[XSnZDDjVGxCOiCyaH;zdIhwenmuYYTpc47DqA>? M13GblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkiwOlc1Lz5{M{[4NFY4PDxxYU6=
A549 NGHXc4VHfW6ldHnvckBCe3OjeR?= MVqxNOKh|ryPwrC= NEjDN2UyKGh? NYqwWIpFemWmdXPld{BCXFEQs2Ot[Y5p[W6lZXSg[Y57gW2jdHnjJIFkfGm4aYT5JI9nKGOSTFGyxsA> Mn;WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4OEC2O|QoRjJ|NkiwOlc1RC:jPh?=
PC12 M2HROGZ2dmO2aX;uJGF{e2G7 NUfYcFRkOTBxMkCvOFAh|ryP M2DWZVHDqGh? M13hPIlvcGmkaYTzJGpPUyCjbnSgdFM5 MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV6NEO1O{c,OjN3OESzOVc9N2F-
HK-2 M3PqVmFxd3C2b4Ppd{BCe3OjeR?= Mn75NlDDqM7:TR?= NHuwSIkzPCCq M2jQbIlvcGmkaYTzJGVTUyCjbnSgdFM5VUGSSx?= M3fmUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUSzNVUyLz5{M{W0N|E2OTxxYU6=
H9c2 MoThSpVv[3Srb36gRZN{[Xl? NV:2c4lIOcLizszN MXOxJIg> NYfK[ZY4emWmdXPld{BVVkZvzsGtbY5lfWOnZDDNUXAuQSCvUl7BJIxmfmWuczDhcoQheHKxbX;0[ZIh[WO2aY\peJk> M4G3fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{WzOlk6Lz5{M{O1N|Y6QTxxYU6=
H9c2 M1HCe2Z2dmO2aX;uJGF{e2G7 MlrxNeKh|ryP NWWwfGV4OSCq MnHWdoVlfWOnczDUUmYu|rFvZX7oZY5k\WRiQWCtNUBxem:vb4TldkBi[3Srdnn0fS=> NYLrRoVJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzOVM3QTlpPkKzN|U{Pjl7PD;hQi=>
H1650  NVvjUJc4TnWwY4Tpc44hSXO|YYm= NVzDNVd1OTEEoN88UeKh NWPWOXJMOSCq M4T6WmROW09? NHLzfZll\WO{ZXHz[ZMh[m:2aDDwdo91\WmwIHHu[EBuWk6DIHzleoVteyCxZjDFVmNEOSCrbjDwZYNtcXSjeHXsMYV5eG:|ZXVCpINmdGy| NYfQVIplRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyNlg3QTZpPkKzNlI5Pjl4PD;hQi=>
H1703 MYjGeY5kfGmxbjDBd5NigQ>? M4HBblExyqEQvF5CpC=> M3r5bFEhcA>? MWLEUXNQ Mnjr[IVkemWjc3XzJIJwfGhicILveIVqdiCjbnSgcXJPSSCuZY\lcJMhd2ZiRWLDR|EhcW5icHHjcIl1[XinbD3lfJBwe2WmwrDj[Yxtew>? NX7PflY2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyNlg3QTZpPkKzNlI5Pjl4PD;hQi=>
H1650  NWXRSJpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVq5fm1KOTEEoN88UeKh MlK3NUBp NGHSTmZFVVOR MmXL[Y5p[W6lZYOgdIFkdGm2YYjlcE1qdmS3Y3XkJIN6fG:2b4jpZ4l1gQ>? NGTPdmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{KyPFY6Pid-MkOyNlg3QTZ:L3G+
H1703 M2fKUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV:xNOKh|ryPwrC= M{TNV|EhcA>? M4nOZWROW09? Mmrk[Y5p[W6lZYOgdIFkdGm2YYjlcE1qdmS3Y3XkJIN6fG:2b4jpZ4l1gQ>? M1vjdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MkK4Olk3Lz5{M{KyPFY6PjxxYU6=
medulloblastoma cells MVLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKG2nZIXscI9jdGG|dH;tZUBk\WyuczDoZZJjd3KrbnegbIV1\XKxeonnc5V{KHC2Y3ixJIdmdmViYomgUXRVKGG|c3H5MEBGSzVyIE2gN{4xODZizszNMi=> M1;iRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG3OlMyLz5zN{SxO|Y{OTxxYU6=
neural precursor cells NYXUelF1SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NYqxcoVCSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDu[ZVz[WxicILlZ5Vze2:{IHPlcIx{KGK7IF3UWEBie3OjeTygSWM2OCB;IEiuNFY{KM7:TT6= NInYd489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SxO|Y{OSd-MUe0NVc3OzF:L3G+
RAW264.7 NVPkPGhWSW62aXnu[oxidW2jdH;yfUBie3OjeR?= Mke5NVAhdWmwcx?= NY[zO5VKSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJG5QKHC{b3T1Z5Rqd25iaX7jeYJifGWmIH\vdkAyOCCvaX7zJJBzcW:{IITvJGxRWy2laHHscIVv\2VibXXhd5Vz\WRiYX\0[ZIhOThiaILzJIJ6KEe{aXXzd{Bu\XSqb3SsJGlEPTBiPTCxOkDPxE1w MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh|MUe5PEc,OjJ6M{G3PVg9N2F-
BL21(DE3) MYHGeY5kfGmxbjDhd5NigQ>? NFexfI03OCCvaX7z M{DTSmlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgbJVu[W5iTj30[ZJucW6jbDDIbZM3NXSjZ3fl[EBDWkR2IHX4dJJme3OnZDDpckBGe2OqZYLpZ4hq[SClb3zpJGJNOjFqRFWzLUBk\WyuczD1d4lv\yCkaX;0bY56dGG2ZXSgbIl{fG:wZTDIOEBx\XC2aXTlJIF{KHO3YoP0doF1\SCjZoTldkA3OCCvaX7zJIJ6KEGucHjhV4Nz\WWwIHHzd4F6NCCLQ{WwJF0hOy52IN88UU4> NIH5N4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG5OVczOyd-MkixPVU4OjN:L3G+
RAW264.7 MoXhSpVv[3Srb36gZZN{[Xl? MXjQdo91\WO2aX;uJIFo[Wmwc4SgRoFkcWyudYOgZY51cHKjY3nzJJBzd3SnY4TpeoUh[W62aXflckBidmRibHX0bIFtKHSxeHnuMYRqeGi2aHXybYEhfG:6aX6gZ4hqdWW{aXOgdJJwfGWrbjDt[YRq[XSnZDDjfZRwfG:6aXPpeJkhcW5ibX;1d4UhWkGZMk[0Mlch[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdIm= MnXyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2OEW1NFQoRjF5NEi1OVA1RC:jPh?=
A673 NWDyWoFbeUiWUzDhd5NigQ>? NEG1fYJyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiQU[3N{Bk\Wyucx?= Mnr0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
DAOY NUfRZoNxeUiWUzDhd5NigQ>? MU\xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhTEGRWTDj[Yxtew>? NVrkdmpjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
RD NGiwc4VyUFSVIHHzd4F6 NIjUbGhyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiUlSgZ4VtdHN? MmLhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
NB1643 MYrxTHRUKGG|c3H5 NHXLV|lyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTlKxOlQ{KGOnbHzz NGfIXnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
BT-12 M2rWU5FJXFNiYYPzZZk> M{XFU5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGJVNTF{IHPlcIx{ M161b|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
LAN-5 M4jvZZFJXFNiYYPzZZk> M{PUNpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGxCVi13IHPlcIx{ MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
Rh41 MoTUdWhVWyCjc4PhfS=> M1vrcpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCUaESxJINmdGy| M4LwdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
NB-EBc1 NG\tNHRyUFSVIHHzd4F6 Ml3jdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgUmIuTUKlMTDj[Yxtew>? MofqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SK-N-SH NH3rfo1yUFSVIHHzd4F6 NGjFOHZyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBUUy2QLWPIJINmdGy| MknTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
A673 M4fzXpFJXFNiYYPzZZk> NH3jRYRyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBCPjd|IHPlcIx{MQ>? MoK3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
BT-37 M4K0bJFJXFNiYYPzZZk> M{\3WJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGJVNTN5IHPlcIx{ NGjkW2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
MG 63 (6-TG R) MXnxTHRUKGG|c3H5 MnvadWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgUWchPjNiKE[tWGchWiliY3XscJM> Mmj2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
Rh30 MYDxTHRUKGG|c3H5 MoDrdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgVog{OCClZXzsdy=> Mn;VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
OHS-50 NYfoW2w3eUiWUzDhd5NigQ>? MWLxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDPTHMuPTBiY3XscJM> M17VeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Rh41 NUHhXoFWeUiWUzDhd5NigQ>? NGjYVGdyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBTcDRzIHPlcIx{ MoXpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SK-N-MC NV6zOZNNeUiWUzDhd5NigQ>? MXHxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?= NYrMVGdzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
NB1643 M2nSfJFJXFNiYYPzZZk> NVXoXlU3eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhVkJzNkSzJINmdGy| MkTiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SK-N-MC MYjxTHRUKGG|c3H5 Mnj4dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgV2suVi2PQzDj[Yxtew>? NV;QO|NqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
SJ-GBM2 NWDk[mpMeUiWUzDhd5NigQ>? MlLTdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgV2ouT0KPMjDj[Yxtew>? MonwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
TC32 MUjxTHRUKGG|c3H5 NXTufHpweUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhXEN|MjDj[Yxtew>? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
Rh18 M171RpFJXFNiYYPzZZk> Mk[xdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgVogyQCClZXzsdy=> NVe4NoJrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
mTOR / p-S6K / S6K / p-S6 / p-AKT / p-MK2; 

PubMed: 26844273     


CRC cells were treated with 10 μM SB202190 for 2 h and analyzed for mTOR signaling and on-target inhibition of p38 by immunoblot. 

pJNK1 / pJNK2 / JNK1 / JNK2 ; 

PubMed: 18222647     


A549 cells were treated with DMSO control or with 10 µM of SB202190 for 0.5, 1, 2, 3, 4, or 6 hours, and pJNK and unphosphorylated JNK were detected as described. 

26844273 18222647
Immunofluorescence
p-p38 / MMP9; 

PubMed: 24479681     


Immunocytochemical staining and confocal microscopy confirmed that IL-1β increased activation of p38 (red), and MMP2 and MMP9 (green) expression in MKN-45 GA cells; these effects were blocked by p38 siRNA or the p38 inhibitor SB202190.

24479681
Growth inhibition assay
Cell viability ; 

PubMed: 26844273     


Top panel: CRC cells were treated with various concentrations of SB202190 for 48 h. Lower panel: CRC cells were treated with SB202190 at 10 μM for different times. Cell growth was measured by SRB assay (means ± s.d. in triplet, n = 3 in triplet).

26844273
体内研究

SB 202190通过抑制p38减弱了由人脊髓灰质炎IgG(PV-IgG)在被动转移小鼠模型中诱发的水泡形成[5]。在脓毒症内毒素模型中,与对照组相比,经SB 202190处理可显著提高存活率[8]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

体外酶活检测:

p38α 和 p38β 溶解在25mM的Tris - HCl缓冲液中,PH 7.5,含0.1mM EGTA,髓鞘碱性蛋白(0.33毫克/毫升)作为底物。人工操作条件用50μL [γ-33P]ATP于30 °C孵育10分钟;Biomek 2000自动化工作站用25μL [γ-33P]ATP在96孔板室温孵育40分钟。ATP和乙酸镁浓度分别为0.1mM和10mM。所有检测都用MgATP起始。人工检测将孵育液滴到磷酸纤维素纸上,浸泡在50mM磷酸中。用5μL磷酸终止反应,后将孵育液点滴在P30过滤垫上。滤膜在50mM磷酸中漂洗四次以去除ATP,在用丙酮(人工孵育)或甲醇(工作站孵育)处理后,干燥并用放射性计量。
细胞实验:

[2]

- 合并
  • Cell lines: Jurkat, 和 HeLa细胞
  • Concentrations: 溶解于DMSO, 终浓度~50 μM
  • Incubation Time: 24 小时
  • Method:

    细胞血清饥饿后,用不同浓度SB 202190处理24小时。用台盼蓝或PI染色后经流式细胞仪分析,以检测细胞活力。凋亡细胞核用H33258染色。


    (Only for Reference)
动物实验:

[5]

- 合并
  • Animal Models: C57BL/6J 小鼠皮内注射无菌的对照IgG或人脊髓灰质炎IgG做对比。
  • Dosages: 12.5 μg
  • Administration: 皮内注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 66 mg/mL (199.19 mM)
Ethanol 12 mg/mL (36.21 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5%DMSO+40%PEG300+5%Tween80+50%H2O
8 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 331.34
化学式

C20H14N3OF

CAS号 152121-30-7
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

p38 MAPK Signaling Pathway Map

p38 MAPK Inhibitors with Unique Features

相关p38 MAPK产品

Tags: 购买SB202190 (FHPI) | SB202190 (FHPI)供应商 | 采购SB202190 (FHPI) | SB202190 (FHPI)价格 | SB202190 (FHPI)生产 | 订购SB202190 (FHPI) | SB202190 (FHPI)代理商
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID