SB202190 (FHPI)

For research use only. Not for use in humans.

目录号:S1077

SB202190 (FHPI) Chemical Structure

CAS No. 152121-30-7

SB202190 (FHPI)是一种有效的p38 MAPK抑制剂,靶向作用于p38α/β,无细胞试验中IC50为50 nM/100 nM,有时用于代替SB 203580研究其在体内对SAPK2a/p38的潜在作用。SB202190 可通过诱导自噬和血红素氧化酶1来抑制内皮细胞的凋亡。SB202190可显著抑制Erastin依赖的铁死亡ferroptosis

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1091.41 现货
RMB 1189.49 现货
RMB 3017.14 现货
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客户使用Selleck生产的SB202190 (FHPI)发表文献118篇:

产品安全说明书

p38 MAPK抑制剂选择性比较

生物活性

产品描述 SB202190 (FHPI)是一种有效的p38 MAPK抑制剂,靶向作用于p38α/β,无细胞试验中IC50为50 nM/100 nM,有时用于代替SB 203580研究其在体内对SAPK2a/p38的潜在作用。SB202190 可通过诱导自噬和血红素氧化酶1来抑制内皮细胞的凋亡。SB202190可显著抑制Erastin依赖的铁死亡ferroptosis
特性 SB 202190 与SB 203580极为相似。
靶点
Ferroptosis [11]
()
p38α [1]
(Cell-free assay)
p38β [1]
(Cell-free assay)
50 nM 100 nM
体外研究

SB 202190显著抑制内源本底和和抗Fas抗体诱导的MAPKAPK 2活性,且抑制效果呈剂量依赖性。SB 202190本身就足以诱导Jurkat细胞和Hela细胞的死亡:通过激活CPP 32样半胱氨酸蛋白酶,可阻断Bcl - 2的表达。p38β可减轻而p38α可加剧由SB 202190诱导的细胞凋亡[2]。在HaCaT细胞中SB 202190强烈抑制由紫外线诱导的cox - 2蛋白表达和 mRNA水平[3]。用SB 202190处理肾小管上皮细胞(正常大鼠k肝脏-52E),可将由白蛋白引发的炎症(单核细胞趋化蛋白-1,MCP - 1)或肿瘤生长因子β-1(TGFβ-1)引发的原纤维化(原骨胶原I a1,procollagen-i alpha1)相关基因降低50%[4]。SB 202190处理A549细胞,可诱导JNK磷酸化(该磷酸化效应呈时间和剂量依赖性)、转录因子ATF - 2磷酸化,并增加AP – 1与DNA的结合[6]。SB 202190处理促进THP-1和MV4-11细胞的生长。SB 202190可提高c-Raf 和ERK(细胞外信号调节激酶)磷酸化,暗示由SB 202190诱导的白血病细胞增殖过程有Ras-Raf-MEK-mitogen激活的MAPK通路的参与[7]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HCT-116 NEO5NoRHfW6ldHnvckBCe3OjeR?= MVWyOUDPxE1? NYTRfmpoOzBibXnu NHG2V4hFVVORwrC= MWXheJRmdnWjdHXzJJRp\SCvUl7BJIFv\CCycn;0[YlvKGW6cILld5Nqd25ib3[gbGJFNTJiaX6gdoV{eG:wc3n2[UB1dyCGQR?= NUXJ[IRKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yNlMzPTFpPkK2NlI{OjVzPD;hQi=>
MDA-MB-231 MUXGeY5kfGmxbjDBd5NigQ>? MViyJO69VQ>? NV6ye3FiOjRiaB?= MWns[ZN{\W6nczDDR2wzKGmwZIXjeIlwdiCkeTDUUmbPuQ>? MmHTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzMEC4OFgoRjJ4MUCwPFQ5RC:jPh?=
rBMSCs M17od2Z2dmO2aX;uJGF{e2G7 MlnCNVAh|ryP M4HWVFIvPSCq Mlf5[IVxemW|c3XzJJRp\SCyaH;zdIhwenmuYYTpc44hd2ZiRWLLJIFv\CCyM{i= NFflenM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC1N|I3Pid-Mk[wOVMzPjZ:L3G+
MG63 NEfXOZZHfW6ldHnvckBCe3OjeR?= M3jONlExNzJyL{OwJO69VQ>? M1;S[VI1KGh? NYrjfnZGe2mpbnnmbYNidnSueTDk[YNz\WG|ZYOgeIhmKGyndnXsJI9nKHCqb4PwbI9zgWyjdHXkJJA{QCCrbnT1Z4VlKGK7IFPkR4wzKGmwIHGgZ49v[2WwdILheIlwdiBvZHXw[Y5l\W62IH3hco5meg>? M{nFWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUm4N|EzLz5{NUm5PFMyOjxxYU6=
MG63 NXvhb2t3SXCxcITvd4l{KEG|c3H5 NFXGbWoyOC9{MD:zNEDPxE1? NUPZSFBtOjRiaB?= MX\zbYdvcW[rY3HueIx6KGSnY4LlZZNm\CC2aHWgZZBweHSxc3nzJJJifGVib3[gUWc3OyCrbnT1Z4VlKGK7IFPkR4wz Mk\tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7OUizNVIoRjJ3OUm4N|EzRC:jPh?=
HTSMCs MkDXSpVv[3Srb36gRZN{[Xl? NUDRbYdmOC5zL{GvNVAh|ryP NI\ZOpEyKGh? MkDZbY5pcWKrdHXkJGNQWk1vMj3pcoR2[2WmIFjPMVEheHKxdHXpckBt\X[nbIOgZY5lKG2UTlGg[ZhxemW|c3nvci=> NG\ZUIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUmyNVQ3PCd-MkW5NlE1PjR:L3G+
MIA PaCa-2 NF;yemVHfW6ldHnvckBCe3OjeR?= MVKyNOKh|ryP MnztNlQhcA>? M1T0OpJm\HWlZXSgcIFkfGG2ZTDhZ4N2dXWuYYTpc44hcW5iY3;tZolv[XSrb36ge4l1cCCkb4ToJFIuTEdiYX7kJGQu[Wyub4PlxsA> NYW1WXFERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4PFg1QDlpPkK1PFg5PDh7PD;hQi=>
MIA PaCa-2 MYnGeY5kfGmxbjDBd5NigQ>? MUKyNOKh|ryP MUmyOEBp NHj0UmZz\XO3bITzJIlvKGFibX;k[ZN1KGmwaHnibZRqd25ib3[gTGlHNTIQsTDwdo91\WmwIHHjZ5VufWyjdHnvci=> NX;TR|lKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4PFg1QDlpPkK1PFg5PDh7PD;hQi=>
BxPC-3 Mm\ZSpVv[3Srb36gRZN{[Xl? NGrNNFkzOMLizszN NXLRNFJkOjRiaB?= MnP3doV{fWy2czDpckBiKG2xZHXzeEBqdmirYnn0bY9vKG:oIFjJSk0y|rFicILveIVqdiCjY3P1cZVt[XSrb36= NXvDUphCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4PFg1QDlpPkK1PFg5PDh7PD;hQi=>
AsPC-1 M1HTfWZ2dmO2aX;uJGF{e2G7 NInqcYMzOMLizszN MoXTNlQhcA>? NHHhXGhz\XO3bITzJIlvKGFibX;k[ZN1KGmwaHnibZRqd25ib3[gTGlHNTIQsTDwdo91\WmwIHHjZ5VufWyjdHnvci=> NHjXTms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi4PFQ5QSd-MkW4PFg1QDl:L3G+
MIA PaCa-2 Mln1SpVv[3Srb36gRZN{[Xl? NF;RRo4zOMLizszN M1fTSFI1KGh? NFrIS2NmdmijbnPld{BkdGWjdnHn[UBw\iCSQWLQJJdp\W5iY3;tZolv\WRid3n0bEBodHWlb4PlJIFv[WyxZ4O= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh6OES4PUc,OjV6OEi0PFk9N2F-
MIA PaCa-2 Mn;IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITHc3czOMLizszN MYWyJIg> M3[0UJNmdnOrdHn6[ZMh[2WubDDsbY5meyC2bzD0doVifG2nboSge4l1cCB{LVTHJIFv\CCGLXHscI9{\Q>? NGTGOGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi4PFQ5QSd-MkW4PFg1QDl:L3G+
BxPC-3 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXTPIUzOMLizszN NVu3V4dOOiCq MUjz[Y5{cXSrenXzJINmdGxibHnu[ZMhfG9idILlZZRu\W62IIfpeIghOi2GRzDhcoQhTC2jbHzvd4U> MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh6OES4PUc,OjV6OEi0PFk9N2F-
AsPC-1 NYHVNXZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvnNlDDqM7:TR?= MluxNkBp NWHsT3FEe2Wwc3n0bZpmeyClZXzsJIxqdmW|IITvJJRz\WG2bXXueEB4cXSqIEKtSGch[W6mIFStZYxtd3On NHXnSm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi4PFQ5QSd-MkW4PFg1QDl:L3G+
HEY M2\xW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rnbVIxyqEQvF2= MkTFNkBp M3nHRZNmdnOrdHn6[ZMh[2WubDDsbY5meyC2bzD0doVifG2nboSge4l1cCB{LVTHJIFv\CCGLXHscI9{\Q>? NXL2Z|NCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4PFg1QDlpPkK1PFg5PDh7PD;hQi=>
OVCAR-3 NXTSVIozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LD[|IxyqEQvF2= M2mwTVIhcA>? NUftRYo2e2Wwc3n0bZpmeyClZXzsJIxqdmW|IITvJJRz\WG2bXXueEB4cXSqIEKtSGch[W6mIFStZYxtd3On MoW4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6OEi0PFkoRjJ3OEi4OFg6RC:jPh?=
SK-OV-3 M3W5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TBN|IxyqEQvF2= NUjCfXBVOiCq NYnKO2Zbe2Wwc3n0bZpmeyClZXzsJIxqdmW|IITvJJRz\WG2bXXueEB4cXSqIEKtSGch[W6mIFStZYxtd3On MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh6OES4PUc,OjV6OEi0PFk9N2F-
MH7A  MnHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY[yOEBp M4S1bZJmcW6ob4Lj[ZMhfGinIHnubIljcXSxcomg[YZn\WO2czDv[kBZSU5? M2\yeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OE[yPVY3Lz5{NUi2Nlk3PjxxYU6=
MH7A  MVfBdI9xfG:|aYOgRZN{[Xl? MXOyOUDPxE1? NH7KV3gzPCCq MoLydoV3\XK|ZYOgZ4VtdCCleXPs[UBienKnc4SgbY5lfWOnZDDifUBZSU5iYX7kJINifXOnZDDhdI9xfG:|aYOgc4Yh[2WubIOgeoliKGGldHn2ZZRqd25ib3[gTm5M NXnzXZpQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4OlI6PjZpPkK1PFYzQTZ4PD;hQi=>
SCC25 Mn3xSpVv[3Srb36gRZN{[Xl? NH72VowzOCEQvF2= M2njZVI1KGh? NE\rd3hqdmO{ZXHz[ZMh[XW2b4DoZYd6KGyndnXs NVTybG5{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4N|Q1ODBpPkK1PFM1PDByPD;hQi=>
HaCaT  MoTGSpVv[3Srb36gRZN{[Xl? MlXvOUDDvU1? NVG1NYt{OjRiaB?= NYX3T|RQcW6qaXLpeJMhUU[QLd8zMYlv\HWlZXSgR2NNOjJicILv[JVkfGmxbjDs[ZZmdHN? NGXqRms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUizOFM2Oyd-MkW4N|Q{PTN:L3G+
HaCaT  MUnGeY5kfGmxbjDBd5NigQ>? M1;idlUhyrWP Ml\0NlQhcA>? NX76cHJScW6qaXLpeJMhUU[QLd8xMYlv\HWlZXSgR2NNOjJicILv[JVkfGmxbjDs[ZZmdHN? NHjL[2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUizOFM2Oyd-MkW4N|Q{PTN:L3G+
HPAEpiCs  MlHvSpVv[3Srb36gRZN{[Xl? NIWwZWoyNzNxMUCg{txO M3uzW|EhcA>? NYPKdIVxemWmdXPld{BUOVBvaX7keYNm\CCLQ1HNMVEheHKxdHXpckBidmRibWLORUBmgHC{ZYPzbY9vKGGwZDDwdo9ud3SncjDhZ5Rqfmm2eR?= MnXMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5M{S5NFAoRjJ3N{O0PVAxRC:jPh?=
HPAEpiCs MVXGeY5kfGmxbjDBd5NigQ>? NYXMXYdJOS9|L{GwJO69VQ>? NEjtOnEyKGh? MofrbY5pcWKrdIOgV|FRNXO2aX31cIF1\WRiQXv0JJBpd3OyaH;yfYxifGmxbjCgxsA> M3:zR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{O0PVAxLz5{NUezOFkxODxxYU6=
HPAEpiCs MUnGeY5kfGmxbjDBd5NigQ>? MnzjNU8{NzFyIN88US=> NHnuTG0yKGh? MXTpcohq[mm2czDTNXAhfGmvZT3k[ZBmdmSnboTsfUB{fGmvdXzheIVlKGNvSoXuJJBpd3OyaH;yfYxifGmxbh?= NVfDS2NWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3N|Q6ODBpPkK1O|M1QTByPD;hQi=>
K562 MlHmSpVv[3Srb36gRZN{[Xl? MnT5NVDDqM7:TR?= Mmr4NeKhcA>? MV3EUXNQ NELsT3hqdmirYnn0d{ByfWmwYXPybY5mNWmwZIXj[YQheDN6IF3BVGsheGixc4Doc5J6dGG2aX;u M2jCVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nki0NFQ{Lz5{NU[4OFA1OzxxYU6=
PANC-1 NF3aVmxHfW6ldHnvckBCe3OjeR?= MVmxNEDPxE1? MY[xJIg> NVH6fnBt\W6qYX7j[ZMhfGinIHH1eI9xcGGpaXOg[YZn\WO2wrC= M1m4PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkOyNlIzLz5{NU[zNlIzOjxxYU6=
BxPC-3 NYjT[2xTTnWwY4Tpc44hSXO|YYm= MX[xNEDPxE1? M{CwRVEhcA>? M2LxO4VvcGGwY3XzJJRp\SCjdYTvdIhi\2mlIHXm[oVkfMLi NF74fXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[zNlIzOid-MkW2N|IzOjJ:L3G+
K562  NXO1fGhNTnWwY4Tpc44hSXO|YYm= Mnj4NE4zPS1zIN88US=> MXGyOEBp NILxR|V{fXCycnXzd4V{KHKnc4\ldoF1em:uLXnu[JVk\WRiSELBXEBxcG:|cHjvdplt[XSrb36= MoexQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4MUmzPVIoRjJ3NkG5N|kzRC:jPh?=
THP-1 MYXGeY5kfGmxbjDBd5NigQ>? NFLwcVk2KML3TR?= Mn3hNkBp M376PJNq\26rZnnjZY51dHliYYT0[Y52[XSnczDz[YNz\XSrb36gc4YhUUxvMd8xJIlv\HWlZXSgZpkhOjeRSFPoc4wheGy3czDGV2wuOcLi NU\iVoJERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1PVg3PjFpPkK1OVk5PjZzPD;hQi=>
WB MnLtSpVv[3Srb36gRZN{[Xl? Mof5NlDjiIoQvF5CpC=> MU[zNQKBkW2rbh?= M3nGVoRm[3KnYYPld{B1cGViTGDTMUBweiCOVFGtbY5lfWOnZDDJUE03KGGwZDDUUmYu|rIEoIDyc4R2[3Srb36= NG\4R4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUWzNFY5Oid-MkW1N|A3QDJ:L3G+
RAW 264.7 NWPQd3JRTnWwY4Tpc44hSXO|YYm= NH;rOYIyOMLizszN MXGzNQKBkW2rbh?= NHnQemVqdmS3Y3XzJINp[XKjY4Tldol{fGmlII\hZ5VwdGG2aX;uJI9nKE:Fc9Mg MmeyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2NkGzPVkoRjJ3NE[xN|k6RC:jPh?=
RAW 264.7 NF7WbmJHfW6ldHnvckBCe3OjeR?= NXX0OJozOTEEoN88US=> M1vn[VMx6oDLbXnu M1PIfYF1fGWwdXH0[ZMhfGinIHXm[oVkfHNib3[gU3BIKG:wIH;zeIVw[2yjc4SgdoV1emGldHnvci=> M1PpSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NE[xN|k6Lz5{NUS2NVM6QTxxYU6=
HaCaT  Mli1SpVv[3Srb36gRZN{[Xl? MWO0NOKh|ryP NEDKV5k{NTJ2IHi= M3jDVWROW09? MYPy[YR2[2W|IITo[UBi[2O3bYXsZZRqd25ib3[gXm8uOQ>? NH\a[449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUSzOVQ5PSd-MkW0N|U1QDV:L3G+
H9c2 NEXyW|lHfW6ldHnvckBCe3OjeR?= M3HjeFUxyqEQvF5CpC=> MoflNVIhcA>? NHnZS3Fz\WS3Y3XzJGxFUCC{ZXzlZZNmKGGwZDDNUXAhdG:|cx?= NYfLOGNlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyOFU5OThpPkK1NlQ2QDF6PD;hQi=>
HSCs NVLVN2JSSXCxcITvd4l{KEG|c3H5 NEe2N5ozPSEQvF2= NVLqZYZuOjUEoHi= NGrZTIx{cWewaX\pZ4FvfGy7IHH0eIVvfWG2ZYOgWGcucW6mdXPl[EBi[3SrdnH0[YQhUFOFczDhdI9xfG:|aYO= NIjHWmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm2NVk2OCd-MkS5OlE6PTB:L3G+
THP-1 MmLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrTO|IhcA>? M3rj[2ROW09? MoPkTWM2OD12LkhOwG0> M4r1c|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEG1NFg4Lz5{NEixOVA5PzxxYU6=
MDDCs MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfyZopRPzJiaB?= Mn[1SG1UVw>? MmHUTWM2ODJwN988US=> NYfTW5ZKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4NVUxQDdpPkK0PFE2ODh5PD;hQi=>
MDDCs NYjCdWdLTnWwY4Tpc44hSXO|YYm= NGrHO3kxNTF3IN88US=> NEjzenQ1QCCq MoP2SG1UVw>? NEm1e3J{fXCycnXzd4V{KEmITj5OtUBidmRiSWCtNVAheHKxZIXjeIlwdsLi NV3LNWhXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4NVUxQDdpPkK0PFE2ODh5PD;hQi=>
MDDCs MX7GeY5kfGmxbjDBd5NigQ>? NVPkZnpnOC1zNTFOwG0> M3[4SlQ5KGh? MlzaSG1UVw>? MXPpcohq[mm2czDNTXAuOWFuIF3JVE0y[iCjbnSgVmFPXEWVIIDyc4R2[3Srb36= MknkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6MUWwPFcoRjJ2OEG1NFg4RC:jPh?=
MDDCs NHrSXJhHfW6ldHnvckBCe3OjeR?= NGruRWsyOCEQvF2= NUjNXlJCOy53IHi= NIjJToVFVVOR MW\icI9kc3NiRVLPWkBIWCxiYoX0JI5wfCCYU2[gS{Bu\WSrYYTl[EBmdnS{eTDpcpRwKGi3bXHuJG1FTEO| MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDhzNUC4O{c,OjR6MUWwPFc9N2F-
macrophages NEPmWXJHfW6ldHnvckBCe3OjeR?= M1n6UFHjiIoQvF2= MYO0MlXjiImq M1rrXoNwdXCuZYTlcJkhcW6qaXLpeJMhVVRvSVnJMYlv\HWlZXSgZYN1cX[jdHnvckBw\iCQRj5OvmI> NHnzN3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEiwPFY{Oyd-MkS4NFg3OzN:L3G+
PDL  MmL3SpVv[3Srb36gRZN{[Xl? M{m3VlIxyqEQvF5CpC=> MnXqN|AhdWmw Mm\tSG1UVw>? MnX3d4lodmmoaXPhcpRtgSCrbnjpZol1eyC2aHWgeIVve2muZTDmc5Jk\S2vZXTpZZRm\CCETWCtNkBmgHC{ZYPzbY9v M1XsR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NU[xNFgyLz5{NEW2NVA5OTxxYU6=
AGS MYjGeY5kfGmxbjDBd5NigQ>? NX6zc4x[PSEQvF2= MkfIN|AhdWmw MVrzeZBxemW|c3XzxsAyNWmwZIXj[YQh[2G|cHHz[U05KGGwZDDjZZNx[XOnLUOgZYN1cX[jdHnvci=> M3ntcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUS3PFc5Lz5{NEW0O|g4QDxxYU6=
H520 MVjGeY5kfGmxbjDBd5NigQ>? M1fIUFExyqEEtV2= M2\o[lEhcA>? NX7xSVZkTE2VTx?= M{HSW4Rm[3KnYYPld{B1cGVicHXt[ZRz\XinZD3pcoR2[2WmIF3TTFIhdVKQQTDhcoQheHKxdHXpckBt\X[nbIO= MlXKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3M{C0O|UoRjJ2NUOwOFc2RC:jPh?=
H1703 MXzGeY5kfGmxbjDBd5NigQ>? NHfyNG4yOMLiwsXN NFraTW8yKGh? NG\qeGVFVVOR NVXCd4JC\GWlcnXhd4V{KHSqZTDw[Y1mfHKneHXkMYlv\HWlZXSgUXNJOiCvUl7BJIFv\CCycn;0[YlvKGyndnXsdy=> M2H3TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUOwOFc2Lz5{NEWzNFQ4PTxxYU6=
H520 NVTPOVQ2TnWwY4Tpc44hSXO|YYm= MVSxNOKhyrWP MWmxNkBp Mmm2SG1UVw>? NH;LendqdmirYnn0d{Bx\W2ndILlfIVlNWWuaXPpeIVlKE2VSEKgdJJwfGWrbjDzeIFjcWyrdIm= Mnz4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3M{C0O|UoRjJ2NUOwOFc2RC:jPh?=
H1703 NV36PHpsTnWwY4Tpc44hSXO|YYm= NHXlT|gyOMLiwsXN MlvONVIhcA>? NWTYNY5lTE2VTx?= MmLKbY5pcWKrdIOgdIVu\XS{ZYjl[E1mdGmlaYTl[EBOW0h{IIDyc5RmcW5ic4ThZoltcXS7 M3L4TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUOwOFc2Lz5{NEWzNFQ4PTxxYU6=
H520 NFXOd2ZHfW6ldHnvckBCe3OjeR?= M3fieVExyqEEtV2= MYC2JIg> NEn2cHBFVVOR Mn3wd4lodmmoaXPhcpRtgSCrbnPy[YF{\XNidHjlJIxmfmWuczDv[kB2[mmzdXn0bY4u[2:waoXnZZRm\CCPU1iyJIlvKHCnbXX0doV5\WRvdILlZZRm\MLiY3XscEBtcW6n MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV|MES3OUc,OjR3M{C0O|U9N2F-
H1703 Mn73SpVv[3Srb36gRZN{[Xl? MljDNVDDqML3TR?= NH3Q[FY3KGh? MWLEUXNQ Mn\Zd4lodmmoaXPhcpRtgSCrbnPy[YF{\XNidHjlJIxmfmWuczDv[kB2[mmzdXn0bY4u[2:waoXnZZRm\CCPU1iyJIlvKHCnbXX0doV5\WRvdILlZZRm\MLiY3XscEBtcW6n NUPzU4tMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1N|A1PzVpPkK0OVMxPDd3PD;hQi=>
MC3T3-E1 M1XNcWZ2dmO2aX;uJGF{e2G7 NInJbZoxNjNxMz:zNEDPxE1? MoLmNUBp MkS4ZZR1\W63YYTld{BVVkZvzsGtbY5lfWOnZDDNUXAuQSCneIDy[ZN{cW:wIHnuJIEh[2:wY3XueJJifGmxbj3k[ZBmdmSnboSgcYFvdmW{wrC= NYrncW1zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NFI3QTZpPkK0OVAzPjl4PD;hQi=>
MC3T3-E1 NHnHNGRHfW6ldHnvckBCe3OjeR?= M4PqeVMxKM7:TR?= MUixJIg> M1rXbYF1fGWwdXH0[ZMhXE6ILd8xMZN1cW23bHH0[YQheDN6IF3BVGsheGixc4Doc5J6dGG2aX;u M{W4clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUCyOlk3Lz5{NEWwNlY6PjxxYU6=
HUVECs  NGO2cVNHfW6ldHnvckBCe3OjeR?= NW\Pc3BvOTEEoNM1US=> MlTRNUBp NED1cW5qdmirYnn0d{BVVkZvzsGtbY5lfWOnZDDDXGNNOSCycn;keYN1cW:w NUC1c5MyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0PFc6PjRpPkK0OFg4QTZ2PD;hQi=>
AGS  NE\MRoFHfW6ldHnvckBCe3OjeR?= NYLO[plsOTEEoNM1US=> NVi5VGpvOzEEoH3pci=> M{\ZcYlvcGmkaYTzJGlNNTIQsj3pcoR2[2WmIHHjeIl3[XSrb36gc4YheDN6 MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR5OU[4NUc,OjR2N{m2PFE9N2F-
MKN-45 NVmwVWtPTnWwY4Tpc44hSXO|YYm= NWjremxFOTEEoNM1US=> MoHTN|DDqG2rbh?= NVKxUlBlcW6qaXLpeJMhUUxvMd8yMYlv\HWlZXSgZYN1cX[jdHnvckBw\iCyM{i= M4LYOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEe5OlgyLz5{NES3PVY5OTxxYU6=
AGS  MkHUSpVv[3Srb36gRZN{[Xl? NYCzeVhQOTEEoNM1US=> M1n5TVMxyqCvaX6= MkfwZZR1\W63YYTld{BKVC1zzsKtbY5lfWOnZDDHRUBk\WyuIH3p[5JifGmxbjDhcoQhcW64YYPpc44> MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR5OU[4NUc,OjR2N{m2PFE9N2F-
MKN-45 M2j6b2Z2dmO2aX;uJGF{e2G7 M1jr[lExyqEEtV2= MVezNOKhdWmw NUTLe3dn[XS2ZX71ZZRmeyCLTD2x{tIucW6mdXPl[EBISSClZXzsJI1q\3KjdHnvckBidmRiaX72ZZNqd25? M3rweVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEe5OlgyLz5{NES3PVY5OTxxYU6=
AGS  NU\1e5hHTnWwY4Tpc44hSXO|YYm= NGfTd4cyOMLiwsXN M3v3WFMxyqCvaX6= MoXrd4lodmmoaXPhcpRtgSCmZXPy[YF{\XNiSXytNe6zNWmwZIXj[YQhVU2SMjDhcoQhVU2SOTDtVm5CKGW6cILld5Nqd25? NXrjcGxNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0O|k3QDFpPkK0OFc6PjhzPD;hQi=>
MKN-45 NXq5OYw5TnWwY4Tpc44hSXO|YYm= MnLENVDDqML3TR?= MVuzNOKhdWmw MYTzbYdvcW[rY3HueIx6KGSnY4LlZZNmeyCLbD2x{tIucW6mdXPl[EBOVVB{IHHu[EBOVVB7IH3SUmEh\XiycnXzd4lwdg>? MlvMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2N{m2PFEoRjJ2NEe5OlgyRC:jPh?=
DCs MXnGeY5kfGmxbjDBd5NigQ>? Mmq5NlDDqM7:TR?= M{GyR|HDqGh? MYTk[YNz\WG|ZYOgTWwuOTJicILv[JVkfGmxbh?= NUPYN|dCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0N|Q3OzZpPkK0OFM1PjN4PD;hQi=>
HUVEC  NITJPXFHfW6ldHnvckBCe3OjeR?= M4H0[VIxKM7:bdMg M37SWVUhcA>? M3LQemROW09? NELqPWVz\WS3Y3XzJIN6fG:taX7lJIV5eHKnc4Ppc44hdGW4ZXzzJIlvKGFiY3;uZ4VvfHKjdHnvck1l\XCnbnTlcpQhdWGwbnXy M{C3SVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUi5NFYzLz5{NEG4PVA3OjxxYU6=
A 549 Ml7kSpVv[3Srb36gRZN{[Xl? M3u4RVUxKM7:TR?= NWflRY5QOSCq MnKw[IVkemWjc3XzJJRp\SCuZY\lcEBw\iCLTD24xsA> NH3OfGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEG3PVY5QCd-MkSxO|k3QDh:L3G+
H520  Ml[ySpVv[3Srb36gRZN{[Xl? M2O0RVUwOTBizszN MnSwNUBp MW\EUXNQ MVfk[YNz\WG|ZYOgUXNJOiCycn;0[YlvKGG|IIflcIwh[XNibWLORUBt\X[nbIOgbY4h\2WoaYTpcoljNWW6cH;z[YQh[2WubB?= MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF|OEmwN{c,OjRzM{i5NFM9N2F-
H1703  MXvGeY5kfGmxbjDBd5NigQ>? MX[1M|ExKM7:TR?= M2TaUlEhcA>? M37KVmROW09? MnLF[IVkemWjc3XzJG1UUDJicILveIVqdiCjczD3[YxtKGG|IH3SUmEhdGW4ZXzzJIlvKGenZnn0bY5q[i2neIDvd4VlKGOnbHy= NXz2NGJlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxN|g6ODNpPkK0NVM5QTB|PD;hQi=>
H520  NFTvNppHfW6ldHnvckBCe3OjeR?= MlSwNVDDqML3TR?= M2fhSFEzKGh? M4TifmROW09? NH\2UVRl\WO{ZXHz[ZMhVVOKMjDtVm5CKGGwZDDwdo91\WmwIIP0ZYJqdGm2eTDpckBo\W[rdHnubYIufHKnYYTl[EBPW0OOQzDj[Yxtew>? MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF|OEmwN{c,OjRzM{i5NFM9N2F-
H1703  NXPkflVjTnWwY4Tpc44hSXO|YYm= M{DOXVExyqEEtV2= NU[wfW85OTJiaB?= Ml[xSG1UVw>? NIDGWZRl\WO{ZXHz[ZMhVVOKMjDtVm5CKGGwZDDwdo91\WmwIIP0ZYJqdGm2eTDpckBo\W[rdHnubYIufHKnYYTl[EBPW0OOQzDj[Yxtew>? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF|OEmwN{c,OjRzM{i5NFM9N2F-
MCF-7  Mn\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDxb2EyOMLizszN MUCyOOKhcA>? MlXlbY5pcWKrdIOgeIhmKEOUMUC4MYlv\HWlZXSgZ4VtdCCmZXH0bC=> MnPDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzMki4OVMoRjJ2MUK4PFU{RC:jPh?=
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HAPI M{TjVGZ2dmO2aX;uJGF{e2G7 NVnNZ3JQOTBxMkCvOFDDqM7:TR?= Mn;tNUBp M1HWS4lvcGmkaYTzJHRETERvaX7keYNm\CCyM{ivTm5MKE2DUFugdIhwe3Cqb4L5cIF1cW:w NUHuVXJqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlkyOjBpPkKzPVY6OTJyPD;hQi=>
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HepG2 MoP1SpVv[3Srb36gRZN{[Xl? NViwSm53OzVyIH7N MoSwNlQhcA>? MWfpcohq[mm2czD0bIUh\GWpdXXsbY4ucW6mdXPl[EBi[3SrdnH0bY9vKG:oIICzPG1CWEt? NUfyb5VoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5N|MyQThpPkKzPVM{OTl6PD;hQi=>
AGS  M{Ha[GZ2dmO2aX;uJGF{e2G7 M3L6TlExyqEQvF2= M2fQPFMxKG2rbh?= MYHpcohq[mm2czDjZZNx[XOnLUOgZYN1cX[jdHnvckBidmRiaX7obYJqfGmxbjDv[kBGWkt? MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh3MEm5OEc,OjN6NUC5PVQ9N2F-
HepG2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTCNE02OCEQvF2= Mn\QOFghcA>? M3fKRYlvcGmkaYTzJJRp\SCycn;sbYZmemG2aX;uJIlvKGFiZH;z[UBl\XCnbnTlcpQhdWGwbnXy NISwUW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iwO|UxQCd-MkO4NFc2ODh:L3G+
BEL7404 NX2xZnZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml75NE02OCEQvF2= Mmm5OFghcA>? M1LOOolvcGmkaYTzJJRp\SCycn;sbYZmemG2aX;uJIlvKGFiZH;z[UBl\XCnbnTlcpQhdWGwbnXy NGHvSI89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iwO|UxQCd-MkO4NFc2ODh:L3G+
HL7702 NF[wXHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;k[VAxNTVyIN88US=> NH3SWFU1QCCq MUjpcohq[mm2czD0bIUheHKxbHnm[ZJifGmxbjDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhyN{WwPEc,OjN6MEe1NFg9N2F-
HepG2 NYXvOG5YTnWwY4Tpc44hSXO|YYm= NFHjcpExNTVyIN88US=> M1fzPFI1KGh? M13pcolvcGmkaYTzJJRp\SCyaH;zdIhwenmuYYTpc44hd2ZicEO4JIRwf26|dILlZY0heHKxdHXpcpMhVUGSS1HQT|ItKEGWRkKsJG1UUzFiYX7kJGhUWDJ5IHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ NVTCNWtJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NFc2ODhpPkKzPFA4PTB6PD;hQi=>
BEAS-2B MknuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjPU2Z{OTBizszN MkfSN|AhdWmw NF3Oeplz\X[ncoPld{B1cGViZHXjdoVie2Vib3[gZ4VtdCC4aXHibYxqfHliaX7keYNm\CCkeTDIR2k> NGX4XlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e4OFA{PCd-MkO3PFQxOzR:L3G+
BEAS-2B MonOR5l1d3SxeHn0fUBCe3OjeR?= MX6xNEDPxE1? NIW3UIg{OCCvaX6= M{LjfYlvcGmkaYTl[EB1cGViaX7jdoVie2ViaX6gUGRJKGGwZDDJUE05KGW6cILld5Nqd25? MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd6NECzOEc,OjN5OESwN|Q9N2F-
BEAS-2B M4X3SGZ2dmO2aX;uJGF{e2G7 MnHhNVAh|ryP NYLmO2QzOzBibXnu NW\tU3R6\GWlcnXhd4V{KHSqZTDs[ZZmdHNib3[gZ4F{eGG|ZT2zMEBD[WRiYX7kJIZiew>? NUPxZ3pnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3PFQxOzRpPkKzO|g1ODN2PD;hQi=>
H9c2  NE\BbIlHfW6ldHnvckBCe3OjeR?= MoPQNE4xOS9yLkGvNUDPxE1? NE[5VnAyKGh? M2n3eoF1fGWwdXH0[ZMhXE6ILd8xMYlv\HWlZXSgUW1RNTliZYjwdoV{e2mxbjygcXJPSSCuZY\lcJMtKGGwZDDwdo9ud3SncjDhZ5Rqfmm2eR?= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd5NEK1Nkc,OjN5N{SyOVI9N2F-
H9c2  Ml3NSpVv[3Srb36gRZN{[Xl? NHLLPWgyKM7:TR?= M1v0blEhcA>? Mn;hdoVlfWOnczDUUmYu|rFiZHny[YN1dHlic4TpcZVt[XSnZDDwN|ghVUGSSzDwbI9{eGixconsZZRqd25? Mlr6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5N{SyOVIoRjJ|N{e0NlUzRC:jPh?=
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U937 NIDiXpNHfW6ldHnvckBCe3OjeR?= MX:xNOKh|ryPwrC= NUjRbG1ZOSCq M1vqRZN2eHC{ZYPz[ZMh[y2MdX6gZY5lKEOURVKgdIhwe3Cqb4L5cIF1cW:wIHnuJINi\m[naX7lMZRz\WG2ZXSgZ4VtdHQEoB?= NIO1U2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ewO|M5Pyd-MkO3NFc{QDd:L3G+
A549 MXXGeY5kfGmxbjDBd5NigQ>? NHr4S5cxNjNxMz:zNEDPxE1? MkP6NUBp MlvRd4lodmmoaXPhcpRtgSCjdITlcpVifGW|IFHUVO6{Wy2vZXTpZZRm\CCFT2itNkBxem:2ZXnuJIFv\CCvUl7BJIV5eHKnc4Ppc44h[W6mIIDyc41wfGW{IHHjeIl3cXS7wrC= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ6ME[3OEc,OjN4OEC2O|Q9N2F-
A549 MlPOSpVv[3Srb36gRZN{[Xl? NH;GUIYyOMLizszNxsA> MknINE0{OCCvaX6= NFvrS5JqdmirYnn0d{BCXFEQs2OgbY5lfWOnZDDwOFIweDR2IF3BVGsh[W6mIICzPEBOSVCNIIDoc5NxcG:{eXzheIlwdg>? MmD5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4OEC2O|QoRjJ|NkiwOlc1RC:jPh?=
A549 MULGeY5kfGmxbjDBd5NigQ>? NVXmTGg1OTEEoN88UeKh M3qzSVEhcA>? MY\pcohq[mm2czDBWHDPu1NiaX7keYNm\CCQRj5OvmIheDZ3IIP1ZpVvcXRicHjvd5Bpd3K7bHH0bY9vKGGwZDDOSk3PwkJicILvcY91\XJiYXP0bZZqfHl? NHHYclQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[4NFY4PCd-MkO2PFA3PzR:L3G+
A549 M2PzR2Z2dmO2aX;uJGF{e2G7 NYDENVBVOTEEoN88UeKh MmD4NUBp NEXBeHFz\WS3Y3XzJGFVWM7|Uz3zeIlufWyjdHXkJINRVEF{IIDoc5NxcG:{eXzheIlwdsLi NVLw[Wp7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2PFA3PzRpPkKzOlgxPjd2PD;hQi=>
A549 MnLUSpVv[3Srb36gRZN{[Xl? M1;uVlExyqEQvF5CpC=> M{jyclEhcA>? M2\KTJJm\HWlZYOgRXRR|rOVLXXubIFv[2WmIHXufplu[XSrYzDhZ5Rqfmm2eTDv[kBkWEyDMtMg NGrXfFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[4NFY4PCd-MkO2PFA3PzR:L3G+
PC12 NFrLSGpHfW6ldHnvckBCe3OjeR?= M4HEblExNzJyL{SwJO69VQ>? NEPuWmgyyqCq MnL6bY5pcWKrdIOgTm5MKGGwZDDwN|g> M3;BfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NUi0N|U4Lz5{M{W4OFM2PzxxYU6=
HK-2 NU\SfWtRSXCxcITvd4l{KEG|c3H5 MnTBNlDDqM7:TR?= M2jIO|I1KGh? NHmycpJqdmirYnn0d{BGWktiYX7kJJA{QE2DUFu= NEDWdYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W0N|E2OSd-MkO1OFMyPTF:L3G+
H9c2 M4HVZ2Z2dmO2aX;uJGF{e2G7 MUixxsDPxE1? MoniNUBp NFjxb29z\WS3Y3XzJHRPTi4QsT3pcoR2[2WmIF3NVE06KG2UTlGgcIV3\Wy|IHHu[EBxem:vb4TldkBi[3Srdnn0fS=> M2m4ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{WzOlk6Lz5{M{O1N|Y6QTxxYU6=
H9c2 M{fq[2Z2dmO2aX;uJGF{e2G7 Mn;ZNeKh|ryP NVPzbmxQOSCq MVPy[YR2[2W|IGTOSk3PuS2nbnjhcoNm\CCDUD2xJJBzd22xdHXyJIFkfGm4aYT5 MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN3M{[5PUc,OjN|NUO2PVk9N2F-
H1650  M4XR[GZ2dmO2aX;uJGF{e2G7 M3XkVVExyqEQvF5CpC=> M2Xnc|EhcA>? NV21NVhQTE2VTx?= Mljs[IVkemWjc3XzJIJwfGhicILveIVqdiCjbnSgcXJPSSCuZY\lcJMhd2ZiRWLDR|EhcW5icHHjcIl1[XinbD3lfJBwe2WmwrDj[Yxtew>? MlS4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{Mki2PVYoRjJ|MkK4Olk3RC:jPh?=
H1703 MVzGeY5kfGmxbjDBd5NigQ>? MXexNOKh|ryPwrC= M1TL[VEhcA>? Mmr3SG1UVw>? MkfY[IVkemWjc3XzJIJwfGhicILveIVqdiCjbnSgcXJPSSCuZY\lcJMhd2ZiRWLDR|EhcW5icHHjcIl1[XinbD3lfJBwe2WmwrDj[Yxtew>? NYe1NlN2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyNlg3QTZpPkKzNlI5Pjl4PD;hQi=>
H1650  MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXP6WXp3OTEEoN88UeKh MWqxJIg> M37jUGROW09? NWPMfGFQ\W6qYX7j[ZMheGGlbHn0ZZhmdC2rbnT1Z4VlKGO7dH;0c5hq[2m2eR?= NUnyTW45RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyNlg3QTZpPkKzNlI5Pjl4PD;hQi=>
H1703 Mn63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVWxNOKh|ryPwrC= MVKxJIg> NFLNeldFVVOR NVX0OZJu\W6qYX7j[ZMheGGlbHn0ZZhmdC2rbnT1Z4VlKGO7dH;0c5hq[2m2eR?= NICyVVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{KyPFY6Pid-MkOyNlg3QTZ:L3G+
medulloblastoma cells NEOwcpJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXjPZ2lpSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDt[YR2dGyxYnzhd5RwdWFiY3XscJMhcGG{Yn;ybY5oKGindHXyc5p6\2:3czDweINpOSCpZX7lJIJ6KE2WVDDhd5NigSxiRVO1NEA:KDNwMEC2JO69VS5? M3PmTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG3OlMyLz5zN{SxO|Y{OTxxYU6=
neural precursor cells MmXtRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MknwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCwZYXyZYwheHKnY4Xyd49zKGOnbHzzJIJ6KE2WVDDhd5NigSxiRVO1NEA:KDhwME[zJO69VS5? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzN{[zNUc,OTd2MUe2N|E9N2F-
RAW264.7 NX:5XXRnSW62aXnu[oxidW2jdH;yfUBie3OjeR?= MnWyNVAhdWmwcx?= NInCUYdCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgUm8heHKxZIXjeIlwdiCrbnP1ZoF1\WRiZn;yJFExKG2rboOgdJJqd3JidH:gUHBUNWOqYXzs[Y5o\SCvZXHzeZJm\CCjZoTldkAyQCCqcoOgZpkhT3KrZYPzJI1mfGixZDygTWM2OCB;IEG2JO69VS5? MonDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6M{G3PVgoRjJ{OEOxO|k5RC:jPh?=
BL21(DE3) M3zCeGZ2dmO2aX;uJIF{e2G7 NIjGNpU3OCCvaX7z Ml72TY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCQLYTldo1qdmGuIFjpd|YufGGpZ3XkJGJTTDRiZYjwdoV{e2WmIHnuJGV{[2incnnjbIliKGOxbHmgRmwzOSiGRUOpJINmdGy|IIXzbY5oKGKrb4Tpcplt[XSnZDDobZN1d26nIFi0JJBmeHSrZHWgZZMhe3Wkc4TyZZRmKGGodHXyJFYxKG2rboOgZpkhSWyyaHHTZ5Jm\W5iYYPzZZktKEmFNUCgQUA{NjRizszNMi=> MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF7NUeyN{c,OjhzOUW3NlM9N2F-
RAW264.7 M3r3eGZ2dmO2aX;uJIF{e2G7 NWe4O5EzWHKxdHXjeIlwdiCjZ3HpcpN1KEKjY3nscJV{KGGwdHjyZYNqeyCycn;0[YN1cX[nIHHueIlo\W5iYX7kJIxmfGijbDD0c5hqdi2maYDoeIhmemmjIITvfIlvKGOqaX3ldolkKHC{b4TlbY4hdWWmaXH0[YQh[3m2b4TvfIlkcXS7IHnuJI1wfXOnIGLBW|I3PC55IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6 NXHFUHFKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PFU2ODRpPkG3OFg2PTB2PD;hQi=>
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... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
mTOR / p-S6K / S6K / p-S6 / p-AKT / p-MK2; 

PubMed: 26844273     


CRC cells were treated with 10 μM SB202190 for 2 h and analyzed for mTOR signaling and on-target inhibition of p38 by immunoblot. 

pJNK1 / pJNK2 / JNK1 / JNK2 ; 

PubMed: 18222647     


A549 cells were treated with DMSO control or with 10 µM of SB202190 for 0.5, 1, 2, 3, 4, or 6 hours, and pJNK and unphosphorylated JNK were detected as described. 

26844273 18222647
Immunofluorescence
p-p38 / MMP9; 

PubMed: 24479681     


Immunocytochemical staining and confocal microscopy confirmed that IL-1β increased activation of p38 (red), and MMP2 and MMP9 (green) expression in MKN-45 GA cells; these effects were blocked by p38 siRNA or the p38 inhibitor SB202190.

24479681
Growth inhibition assay
Cell viability ; 

PubMed: 26844273     


Top panel: CRC cells were treated with various concentrations of SB202190 for 48 h. Lower panel: CRC cells were treated with SB202190 at 10 μM for different times. Cell growth was measured by SRB assay (means ± s.d. in triplet, n = 3 in triplet).

26844273
体内研究

SB 202190通过抑制p38减弱了由人脊髓灰质炎IgG(PV-IgG)在被动转移小鼠模型中诱发的水泡形成[5]。在脓毒症内毒素模型中,与对照组相比,经SB 202190处理可显著提高存活率[8]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

体外酶活检测:

p38α 和 p38β 溶解在25mM的Tris - HCl缓冲液中,PH 7.5,含0.1mM EGTA,髓鞘碱性蛋白(0.33毫克/毫升)作为底物。人工操作条件用50μL [γ-33P]ATP于30 °C孵育10分钟;Biomek 2000自动化工作站用25μL [γ-33P]ATP在96孔板室温孵育40分钟。ATP和乙酸镁浓度分别为0.1mM和10mM。所有检测都用MgATP起始。人工检测将孵育液滴到磷酸纤维素纸上,浸泡在50mM磷酸中。用5μL磷酸终止反应,后将孵育液点滴在P30过滤垫上。滤膜在50mM磷酸中漂洗四次以去除ATP,在用丙酮(人工孵育)或甲醇(工作站孵育)处理后,干燥并用放射性计量。
细胞实验:

[2]

- 合并
  • Cell lines: Jurkat, 和 HeLa细胞
  • Concentrations: 溶解于DMSO, 终浓度~50 μM
  • Incubation Time: 24 小时
  • Method:

    细胞血清饥饿后,用不同浓度SB 202190处理24小时。用台盼蓝或PI染色后经流式细胞仪分析,以检测细胞活力。凋亡细胞核用H33258染色。


    (Only for Reference)
动物实验:

[5]

- 合并
  • Animal Models: C57BL/6J 小鼠皮内注射无菌的对照IgG或人脊髓灰质炎IgG做对比。
  • Dosages: 12.5 μg
  • Administration: 皮内注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 66 mg/mL (199.19 mM)
Ethanol 12 mg/mL (36.21 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5%DMSO+40%PEG300+5%Tween80+50%H2O
8 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 331.34
化学式

C20H14N3OF

CAS号 152121-30-7
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

p38 MAPK Signaling Pathway Map

p38 MAPK Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID