SB202190 (FHPI)

For research use only. Not for use in humans.

目录号:S1077

SB202190 (FHPI) Chemical Structure

CAS No. 152121-30-7

SB202190 (FHPI)是一种有效的p38 MAPK抑制剂,靶向作用于p38α/β,无细胞试验中IC50为50 nM/100 nM,有时用于代替SB 203580研究其在体内对SAPK2a/p38的潜在作用。SB202190 可通过诱导自噬和血红素氧化酶1来抑制内皮细胞的凋亡。SB202190可显著抑制Erastin依赖的铁死亡ferroptosis

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1091.41 现货
RMB 1189.49 现货
RMB 3017.14 现货
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客户使用Selleck生产的SB202190 (FHPI)发表文献99篇:

产品安全说明书

p38 MAPK抑制剂选择性比较

生物活性

产品描述 SB202190 (FHPI)是一种有效的p38 MAPK抑制剂,靶向作用于p38α/β,无细胞试验中IC50为50 nM/100 nM,有时用于代替SB 203580研究其在体内对SAPK2a/p38的潜在作用。SB202190 可通过诱导自噬和血红素氧化酶1来抑制内皮细胞的凋亡。SB202190可显著抑制Erastin依赖的铁死亡ferroptosis
特性 SB 202190 与SB 203580极为相似。
靶点
Ferroptosis [11]
()
p38α [1]
(Cell-free assay)
p38β [1]
(Cell-free assay)
50 nM 100 nM
体外研究

SB 202190显著抑制内源本底和和抗Fas抗体诱导的MAPKAPK 2活性,且抑制效果呈剂量依赖性。SB 202190本身就足以诱导Jurkat细胞和Hela细胞的死亡:通过激活CPP 32样半胱氨酸蛋白酶,可阻断Bcl - 2的表达。p38β可减轻而p38α可加剧由SB 202190诱导的细胞凋亡[2]。在HaCaT细胞中SB 202190强烈抑制由紫外线诱导的cox - 2蛋白表达和 mRNA水平[3]。用SB 202190处理肾小管上皮细胞(正常大鼠k肝脏-52E),可将由白蛋白引发的炎症(单核细胞趋化蛋白-1,MCP - 1)或肿瘤生长因子β-1(TGFβ-1)引发的原纤维化(原骨胶原I a1,procollagen-i alpha1)相关基因降低50%[4]。SB 202190处理A549细胞,可诱导JNK磷酸化(该磷酸化效应呈时间和剂量依赖性)、转录因子ATF - 2磷酸化,并增加AP – 1与DNA的结合[6]。SB 202190处理促进THP-1和MV4-11细胞的生长。SB 202190可提高c-Raf 和ERK(细胞外信号调节激酶)磷酸化,暗示由SB 202190诱导的白血病细胞增殖过程有Ras-Raf-MEK-mitogen激活的MAPK通路的参与[7]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HCT-116 MVnGeY5kfGmxbjDBd5NigQ>? NH7TdnAzPSEQvF2= NYnpcGs3OzBibXnu NUTQSmRvTE2VT9Mg NGmye2tifHSnboXheIV{KHSqZTDtVm5CKGGwZDDwdo91\WmwIHX4dJJme3Orb36gc4YhcEKGLUKgbY4hemW|cH;ud4l3\SC2bzDERS=> MlLBNlYzOjN{NUG=
MDA-MB-231 MV3GeY5kfGmxbjDBd5NigQ>? MUiyJO69VQ>? MnLBNlQhcA>? Ml75cIV{e2WwZYOgR2NNOiCrbnT1Z5Rqd25iYomgWG5H|rF? MoDiNlYyODB6NEi=
rBMSCs M2jiVWZ2dmO2aX;uJGF{e2G7 NFvSbpkyOCEQvF2= NVWyXHd[Oi53IHi= NXvyeJN1\GWycnXzd4V{KHSqZTDwbI9{eGixconsZZRqd25ib3[gSXJMKGGwZDDwN|g> NV3D[WFQOjZyNUOyOlY>
MG63 MW\GeY5kfGmxbjDBd5NigQ>? MnuyNVAwOjBxM{Cg{txO NUnhWZlwOjRiaB?= MXzzbYdvcW[rY3HueIx6KGSnY4LlZZNmeyC2aHWgcIV3\Wxib3[gdIhwe3Cqb4L5cIF1\WRicEO4JIlv\HWlZXSgZpkhS2SFbEKgbY4h[SClb37j[Y51emG2aX;uJE1l\XCnbnTlcpQhdWGwbnXy M1Sx[VI2QTl6M{Gy
MG63 NXfGdmM{SXCxcITvd4l{KEG|c3H5 NYHTNohxOTBxMkCvN|Ah|ryP MlfONlQhcA>? NEnjOIR{cWewaX\pZ4FvfGy7IHTlZ5Jm[XOnZDD0bIUh[XCxcITvd4l{KHKjdHWgc4YhVUd4MzDpcoR2[2WmIHL5JGNlS2x{ NYXXOnJWOjV7OUizNVI>
HTSMCs MX\GeY5kfGmxbjDBd5NigQ>? NFLkN3ExNjFxMT:xNEDPxE1? NEnJcXAyKGh? NUDodGpxcW6qaXLpeIVlKEORUl2tNk1qdmS3Y3XkJGhQNTFicILveIVqdiCuZY\lcJMh[W6mIH3SUmEh\XiycnXzd4lwdg>? NHTMZpgzPTl{MUS2OC=>
MIA PaCa-2 MVHGeY5kfGmxbjDBd5NigQ>? M1q5clIxyqEQvF2= MUCyOEBp MYDy[YR2[2WmIHzhZ5RifGViYXPjeY12dGG2aX;uJIlvKGOxbXLpcoF1cW:wIIfpeIgh[m:2aDCyMWRIKGGwZDDEMYFtdG:|ZdMg NVPIW5FLOjV6OEi0PFk>
MIA PaCa-2 M{TLVGZ2dmO2aX;uJGF{e2G7 MUOyNOKh|ryP MVSyOEBp NETIeJpz\XO3bITzJIlvKGFibX;k[ZN1KGmwaHnibZRqd25ib3[gTGlHNTIQsTDwdo91\WmwIHHjZ5VufWyjdHnvci=> NYDDWIM2OjV6OEi0PFk>
BxPC-3 NEPreW5HfW6ldHnvckBCe3OjeR?= MX6yNOKh|ryP NYK4W3A4OjRiaB?= NIPv[YJz\XO3bITzJIlvKGFibX;k[ZN1KGmwaHnibZRqd25ib3[gTGlHNTIQsTDwdo91\WmwIHHjZ5VufWyjdHnvci=> M1TNT|I2QDh6NEi5
AsPC-1 Mn3kSpVv[3Srb36gRZN{[Xl? NUTNXndEOjEEoN88US=> NFjlU3gzPCCq NXThOHc6emW|dXz0d{BqdiCjIH3v[IV{fCCrbnjpZol1cW:wIH;mJGhKTi1zzsGgdJJwfGWrbjDhZ4N2dXWuYYTpc44> MW[yOVg5QDR6OR?=
MIA PaCa-2 NVrkN5V4TnWwY4Tpc44hSXO|YYm= M3ryfFIxyqEQvF2= NH3pXWkzPCCq MWXlcohidmOnczDjcIVifmGpZTDv[kBRSVKSIIfo[Y4h[2:vYnnu[YQhf2m2aDDncJVkd3OnIHHuZYxw\3N? NFrHfpkzPTh6OES4PS=>
MIA PaCa-2 NU\TTZVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPjNIszOMLizszN MVqyJIg> NG\te4x{\W6|aYTpfoV{KGOnbHygcIlv\XNidH:geJJm[XSvZX70JJdqfGhiMj3ES{BidmRiRD3hcIxwe2V? MYGyOVg5QDR6OR?=
BxPC-3 M2juT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vvRVIxyqEQvF2= NG\6T2YzKGh? M2\mcJNmdnOrdHn6[ZMh[2WubDDsbY5meyC2bzD0doVifG2nboSge4l1cCB{LVTHJIFv\CCGLXHscI9{\Q>? MoXmNlU5QDh2OEm=
AsPC-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWCyNOKh|ryP MV[yJIg> MYHz[Y5{cXSrenXzJINmdGxibHnu[ZMhfG9idILlZZRu\W62IIfpeIghOi2GRzDhcoQhTC2jbHzvd4U> M2PWbVI2QDh6NEi5
HEY MknUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[xNlDDqM7:TR?= NFPnXXUzKGh? NVvwe41pe2Wwc3n0bZpmeyClZXzsJIxqdmW|IITvJJRz\WG2bXXueEB4cXSqIEKtSGch[W6mIFStZYxtd3On MkGyNlU5QDh2OEm=
OVCAR-3 NHPnSYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPo[HR5OjEEoN88US=> M1;JZVIhcA>? Mnrqd4Vve2m2aYrld{Bk\WyuIHzpcoV{KHSxIITy[YF1dWWwdDD3bZRpKDJvRFegZY5lKERvYXzsc5Nm NUfD[ldrOjV6OEi0PFk>
SK-OV-3 NVHQVmh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYKyNOKh|ryP MYWyJIg> NVP1UVVQe2Wwc3n0bZpmeyClZXzsJIxqdmW|IITvJJRz\WG2bXXueEB4cXSqIEKtSGch[W6mIFStZYxtd3On MUWyOVg5QDR6OR?=
MH7A  MkPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX60cHlDOjRiaB?= MXjy[Ylv\m:{Y3XzJJRp\SCrbnjpZol1d3K7IHXm[oVkfHNib3[gXGFP NFvuPZozPTh4Mkm2Oi=>
MH7A  MkmxRZBweHSxc3nzJGF{e2G7 NF;rNmkzPSEQvF2= M3PNeVI1KGh? NIm1d4Rz\X[ncoPld{Bk\WyuIHP5Z4xmKGG{cnXzeEBqdmS3Y3XkJIJ6KFiDTjDhcoQh[2G3c3XkJIFxd3C2b4Ppd{Bw\iClZXzsd{B3cWFiYXP0bZZifGmxbjDv[kBLVkt? NE[3[4IzPTh4Mkm2Oi=>
SCC25 MmnaSpVv[3Srb36gRZN{[Xl? M{f4NVIxKM7:TR?= NUXiZ|JIOjRiaB?= M2LocIlv[3KnYYPld{BifXSxcHjh[5khdGW4ZXy= NYfKZZN4OjV6M{S0NFA>
HaCaT  NHnwOXpHfW6ldHnvckBCe3OjeR?= MX61JOK2VQ>? MmqyNlQhcA>? NYC3UWVwcW6qaXLpeJMhUU[QLd8zMYlv\HWlZXSgR2NNOjJicILv[JVkfGmxbjDs[ZZmdHN? MYGyOVg{PDN3Mx?=
HaCaT  MknQSpVv[3Srb36gRZN{[Xl? M1;UbFUhyrWP NYLZV|BVOjRiaB?= MVvpcohq[mm2czDJSm4u|rFvaX7keYNm\CCFQ1yyNkBxem:mdXP0bY9vKGyndnXsdy=> M1vkcFI2QDN2M{Wz
HPAEpiCs  NGfVW3pHfW6ldHnvckBCe3OjeR?= MmDSNU8{NzFyIN88US=> M1i0elEhcA>? MWjy[YR2[2W|IGOxVE1qdmS3Y3XkJGlESU1vMTDwdo91\WmwIHHu[EBuWk6DIHX4dJJme3Orb36gZY5lKHC{b33veIVzKGGldHn2bZR6 MViyOVc{PDlyMB?=
HPAEpiCs MkfmSpVv[3Srb36gRZN{[Xl? Ml[0NU8{NzFyIN88US=> NVyx[5B1OSCq M1Pr[4lvcGmkaYTzJHMyWC2|dHnteYxifGWmIFHreEBxcG:|cHjvdplt[XSrb36gJOKh MlzUNlU4OzR7MEC=
HPAEpiCs NFPqPYNHfW6ldHnvckBCe3OjeR?= NUP4XXlpOS9|L{GwJO69VQ>? M2HiblEhcA>? MXXpcohq[mm2czDTNXAhfGmvZT3k[ZBmdmSnboTsfUB{fGmvdXzheIVlKGNvSoXuJJBpd3OyaH;yfYxifGmxbh?= NF\B[FgzPTd|NEmwNC=>
K562 NXL5THNCTnWwY4Tpc44hSXO|YYm= MUixNOKh|ryP NIjWNG0yyqCq MV;EUXNQ NHjDfWdqdmirYnn0d{ByfWmwYXPybY5mNWmwZIXj[YQheDN6IF3BVGsheGixc4Doc5J6dGG2aX;u MWOyOVY5PDB2Mx?=
PANC-1 NVzGTZE2TnWwY4Tpc44hSXO|YYm= NGPkfIwyOCEQvF2= NXrHeohwOSCq MVnlcohidmOnczD0bIUh[XW2b4DoZYdq[yCnZn\lZ5TDqA>? MnTxNlU3OzJ{MkK=
BxPC-3 MWfGeY5kfGmxbjDBd5NigQ>? NWHITZRYOTBizszN NY\ZO3VWOSCq NYT5TFZC\W6qYX7j[ZMhfGinIHH1eI9xcGGpaXOg[YZn\WO2wrC= MW[yOVY{OjJ{Mh?=
K562  MkK5SpVv[3Srb36gRZN{[Xl? MlO3NE4zPS1zIN88US=> MlXQNlQhcA>? Ml3nd5VxeHKnc4Pld{Bz\XO4ZYLheJJwdC2rbnT1Z4VlKEh{QWigdIhwe3Cqb4L5cIF1cW:w MYWyOVYyQTN7Mh?=
THP-1 Mnf0SpVv[3Srb36gRZN{[Xl? NULWTIFKPSEEtV2= M2PaPVIhcA>? MWDzbYdvcW[rY3HueIx6KGG2dHXueYF1\XNic3XjdoV1cW:wIH;mJGlNNTIQsTDpcoR2[2WmIHL5JFI4V0iFaH;sJJBtfXNiRmPMMVHDqA>? NXXKT|lLOjV3OUi2OlE>
WB NI\6fpdHfW6ldHnvckBCe3OjeR?= M3XxTFIx6oDLzszNxsA> NVzQTJU{OzEkgJntbY4> M1\OUYRm[3KnYYPld{B1cGViTGDTMUBweiCOVFGtbY5lfWOnZDDJUE03KGGwZDDUUmYu|rIEoIDyc4R2[3Srb36= MmDXNlU2OzB4OEK=
RAW 264.7 NVfEbGsxTnWwY4Tpc44hSXO|YYm= NI\WfYEyOMLizszN NFr5e5M{OOLCiX3pci=> MnTJbY5lfWOnczDjbIFz[WO2ZYLpd5Rq[yC4YXP1c4xifGmxbjDv[kBQS3QEoB?= NF\yTYgzPTR4MUO5PS=>
RAW 264.7 NYn3XZJDTnWwY4Tpc44hSXO|YYm= MmH3NVDDqM7:TR?= NXP0[ZhYOzEkgJntbY4> NI\lTYVifHSnboXheIV{KHSqZTDl[oZm[3S|IH;mJG9RTyCxbjDvd5Rmd2OuYYP0JJJmfHKjY4Tpc44> NUnIXWdIOjV2NkGzPVk>
HaCaT  NV7TOI5wTnWwY4Tpc44hSXO|YYm= Ml\wOFDDqM7:TR?= MnH2N{0zPCCq NFL1dGlFVVOR M2i1SpJm\HWlZYOgeIhmKGGlY4XteYxifGmxbjDv[kBbVy1z NYfHVGg4OjV2M{W0PFU>
H9c2 NWfPO3BMTnWwY4Tpc44hSXO|YYm= MmDPOVDDqM7:TdMg Mn\qNVIhcA>? NIC5RpRz\WS3Y3XzJGxFUCC{ZXzlZZNmKGGwZDDNUXAhdG:|cx?= MkL6NlUzPDV6MUi=
HSCs MnTjRZBweHSxc3nzJGF{e2G7 MonFNlUh|ryP NHewelQzPMLiaB?= MVjzbYdvcW[rY3HueIx6KGG2dHXueYF1\XNiVFetbY5lfWOnZDDhZ5RqfmG2ZXSgTHNEeyCjcH;weI9{cXN? NV\rZ3FVOjR7NkG5OVA>
THP-1 NV23eFBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofDO|IhcA>? MnywSG1UVw>? MUPJR|UxRTRwN988US=> M{PMTFI1QDF3MEi3
MDDCs NH3me2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;GUVczKGh? NUXNWVhETE2VTx?= MmPVTWM2ODJwN988US=> NUfDOo13OjR6MUWwPFc>
MDDCs MUfGeY5kfGmxbjDBd5NigQ>? MWGwMVE2KM7:TR?= MYm0PEBp NWWwR|BHTE2VTx?= M1nJNZN2eHC{ZYPz[ZMhUU[QLd8xJIFv\CCLUD2xNEBxem:mdXP0bY9vyqB? M4HUO|I1QDF3MEi3
MDDCs NFPl[5hHfW6ldHnvckBCe3OjeR?= M2rESFAuOTVizszN M4PYXFQ5KGh? M{ewfGROW09? NFT1bYJqdmirYnn0d{BOUVBvMXGsJG1KWC1zYjDhcoQhWkGQVFXTJJBzd2S3Y4Tpc44> NVnMfFVMOjR6MUWwPFc>
MDDCs MVnGeY5kfGmxbjDBd5NigQ>? NGWwTpQyOCEQvF2= NGf5eGI{NjViaB?= M13iWmROW09? MW\icI9kc3NiRVLPWkBIWCxiYoX0JI5wfCCYU2[gS{Bu\WSrYYTl[EBmdnS{eTDpcpRwKGi3bXHuJG1FTEO| Mk\iNlQ5OTVyOEe=
macrophages MoO4SpVv[3Srb36gRZN{[Xl? NFGwXVgy6oDLzszN Mn[xOE426oDLaB?= M2DLdINwdXCuZYTlcJkhcW6qaXLpeJMhVVRvSVnJMYlv\HWlZXSgZYN1cX[jdHnvckBw\iCQRj5OvmI> M37MRVI1QDB6NkOz
PDL  M2PXUGZ2dmO2aX;uJGF{e2G7 M4r2XVIxyqEQvF5CpC=> NX7tUJhFOzBibXnu NEjxSlNFVVOR M3m0W5Nq\26rZnnjZY51dHliaX7obYJqfHNidHjlJJRmdnOrbHWg[o9z[2VvbXXkbYF1\WRiQl3QMVIh\XiycnXzd4lwdg>? NGTHZ5ozPDV4MUC4NS=>
AGS MYrGeY5kfGmxbjDBd5NigQ>? Mkj6OUDPxE1? M1voUFMxKG2rbh?= NH\jdI1{fXCycnXzd4V{yqBzLXnu[JVk\WRiY3HzdIF{\S16IHHu[EBk[XOyYYPlMVMh[WO2aY\heIlwdg>? M3n2clI1PTR5OEe4
H520 MlK3SpVv[3Srb36gRZN{[Xl? NYPpXpNmOTEEoNM1US=> MX:xJIg> NILLRnlFVVOR MYjk[YNz\WG|ZYOgeIhmKHCnbXX0doV5\WRvaX7keYNm\CCPU1iyJI1TVkFiYX7kJJBzd3SnaX6gcIV3\Wy| MoTwNlQ2OzB2N{W=
H1703 NGjOdmlHfW6ldHnvckBCe3OjeR?= NXfW[Go2OTEEoNM1US=> NGXz[G8yKGh? MorUSG1UVw>? NVft[lRZ\GWlcnXhd4V{KHSqZTDw[Y1mfHKneHXkMYlv\HWlZXSgUXNJOiCvUl7BJIFv\CCycn;0[YlvKGyndnXsdy=> M2DpelI1PTNyNEe1
H520 NHnGbGtHfW6ldHnvckBCe3OjeR?= NEi2cJEyOMLiwsXN NI\pd2oyOiCq NG\WdWxFVVOR NWTnfZo6cW6qaXLpeJMheGWvZYTy[Zhm\C2nbHnjbZRm\CCPU1iyJJBzd3SnaX6gd5Ri[mmuaYT5 NVPCW2VtOjR3M{C0O|U>
H1703 MWLGeY5kfGmxbjDBd5NigQ>? NY\ZbnZFOTEEoNM1US=> M1P3OlEzKGh? Mnr3SG1UVw>? NE[2ZnJqdmirYnn0d{Bx\W2ndILlfIVlNWWuaXPpeIVlKE2VSEKgdJJwfGWrbjDzeIFjcWyrdIm= NIT6cnEzPDV|MES3OS=>
H520 NGHKfmFHfW6ldHnvckBCe3OjeR?= MojKNVDDqML3TR?= NGPxXoY3KGh? M4DFTmROW09? NXnlZY1ke2mpbnnmbYNidnSueTDpcoNz\WG|ZYOgeIhmKGyndnXsd{Bw\iC3YnnxeYl1cW5vY3;ubpVo[XSnZDDNV2gzKGmwIIDlcYV1emW6ZXSteJJm[XSnZNMgZ4VtdCCuaX7l NWjxc4U3OjR3M{C0O|U>
H1703 M3v4UWZ2dmO2aX;uJGF{e2G7 MXqxNOKhyrWP Ml;JOkBp M4HOeWROW09? MUTzbYdvcW[rY3HueIx6KGmwY4LlZZNmeyC2aHWgcIV3\Wy|IH;mJJVjcXG3aYTpck1kd26sdXfheIVlKE2VSEKgbY4heGWvZYTy[Zhm\C22cnXheIVlyqClZXzsJIxqdmV? NH\iWVYzPDV|MES3OS=>
MC3T3-E1 NVXzTXhSTnWwY4Tpc44hSXO|YYm= NFnqXpQxNjNxMz:zNEDPxE1? NVfnPHpYOSCq M1zFN4F1fGWwdXH0[ZMhXE6ILd8xMYlv\HWlZXSgUW1RNTliZYjwdoV{e2mxbjDpckBiKGOxbnPlcpRz[XSrb36t[IVx\W6mZX70JI1idm6nctMg MX:yOFUxOjZ7Nh?=
MC3T3-E1 MWjGeY5kfGmxbjDBd5NigQ>? MXmzNEDPxE1? MkjiNUBp MVfheJRmdnWjdHXzJHRPTi4QsT3zeIlufWyjdHXkJJA{QCCPQWDLJJBpd3OyaH;yfYxifGmxbh?= MmqzNlQ2ODJ4OU[=
HUVECs  MmnESpVv[3Srb36gRZN{[Xl? MmnLNVDDqML3TR?= MlrXNUBp NUS0WZc1cW6qaXLpeJMhXE6ILd8xMYlv\HWlZXSgR3hEVDFicILv[JVkfGmxbh?= M{PKNVI1PDh5OU[0
AGS  NUTibWp3TnWwY4Tpc44hSXO|YYm= NVuze2NkOTEEoNM1US=> NHnyb2U{OMLibXnu MV\pcohq[mm2czDJUE0y|rJvaX7keYNm\CCjY4TpeoF1cW:wIH;mJJA{QA>? M2jxOVI1PDd7Nkix
MKN-45 NUjIeXJnTnWwY4Tpc44hSXO|YYm= Ml;rNVDDqML3TR?= NUfXZYx6OzEEoH3pci=> MWPpcohq[mm2czDJUE0y|rJvaX7keYNm\CCjY4TpeoF1cW:wIH;mJJA{QA>? NIfvWoozPDR5OU[4NS=>
AGS  MWnGeY5kfGmxbjDBd5NigQ>? M2PpVFExyqEEtV2= NXPzU4prOzEEoH3pci=> MoHWZZR1\W63YYTld{BKVC1zzsKtbY5lfWOnZDDHRUBk\WyuIH3p[5JifGmxbjDhcoQhcW64YYPpc44> MnHRNlQ1Pzl4OEG=
MKN-45 NYfiZXpmTnWwY4Tpc44hSXO|YYm= NXvpVJJDOTEEoNM1US=> NIjoUnU{OMLibXnu NX;GRYlH[XS2ZX71ZZRmeyCLTD2x{tIucW6mdXPl[EBISSClZXzsJI1q\3KjdHnvckBidmRiaX72ZZNqd25? NETvWGMzPDR5OU[4NS=>
AGS  M2e5N2Z2dmO2aX;uJGF{e2G7 Mn;WNVDDqML3TR?= NYXF[m83OzEEoH3pci=> MlXSd4lodmmoaXPhcpRtgSCmZXPy[YF{\XNiSXytNe6zNWmwZIXj[YQhVU2SMjDhcoQhVU2SOTDtVm5CKGW6cILld5Nqd25? NVqwUY9yOjR2N{m2PFE>
MKN-45 M1zjdmZ2dmO2aX;uJGF{e2G7 MUKxNOKhyrWP NHvXdYY{OMLibXnu NVjKTVhke2mpbnnmbYNidnSueTDk[YNz\WG|ZYOgTYwuOc7{LXnu[JVk\WRiTV3QNkBidmRiTV3QPUBuWk6DIHX4dJJme3Orb36= NH3oPWYzPDR5OU[4NS=>
DCs MleySpVv[3Srb36gRZN{[Xl? MknoNlDDqM7:TR?= NFPueYgyyqCq MkPV[IVkemWjc3XzJGlNNTF{IIDyc4R2[3Srb36= MVOyOFQ{PDZ|Nh?=
HUVEC  NYjhTFMxTnWwY4Tpc44hSXO|YYm= MmH1NlAh|ryvwrC= Mn;QOUBp NE[wTGJFVVOR MXvy[YR2[2W|IHP5eI9scW6nIHX4dJJme3Orb36gcIV3\Wy|IHnuJIEh[2:wY3XueJJifGmxbj3k[ZBmdmSnboSgcYFvdmW{ NGLFSJEzPDF6OUC2Ni=>
A 549 MXHGeY5kfGmxbjDBd5NigQ>? MUm1NEDPxE1? NHT0bGoyKGh? MW\k[YNz\WG|ZYOgeIhmKGyndnXsJI9nKEmOLUlCpC=> Mn:zNlQyPzl4OEi=
H520  M1T3fGZ2dmO2aX;uJGF{e2G7 MVG1M|ExKM7:TR?= NFL6Oo0yKGh? NV7jNlZ6TE2VTx?= MWTk[YNz\WG|ZYOgUXNJOiCycn;0[YlvKGG|IIflcIwh[XNibWLORUBt\X[nbIOgbY4h\2WoaYTpcoljNWW6cH;z[YQh[2WubB?= NFrSVVMzPDF|OEmwNy=>
H1703  Mnu2SpVv[3Srb36gRZN{[Xl? MnHhOU8yOCEQvF2= NInVS24yKGh? M1H3SWROW09? M{HKOYRm[3KnYYPld{BOW0h{IIDyc5RmcW5iYYOge4VtdCCjczDtVm5CKGyndnXsd{BqdiCpZX\peIlvcWJvZYjwc5Nm\CClZXzs NUfHTGxQOjRzM{i5NFM>
H520  MX;GeY5kfGmxbjDBd5NigQ>? MWWxNOKhyrWP NULsNHExOTJiaB?= NW\wXnU6TE2VTx?= NGTJeWtl\WO{ZXHz[ZMhVVOKMjDtVm5CKGGwZDDwdo91\WmwIIP0ZYJqdGm2eTDpckBo\W[rdHnubYIufHKnYYTl[EBPW0OOQzDj[Yxtew>? MljCNlQyOzh7MEO=
H1703  NX3OcJlJTnWwY4Tpc44hSXO|YYm= NXXI[o96OTEEoNM1US=> MWOxNkBp NUfncVJZTE2VTx?= M1X6fYRm[3KnYYPld{BOW0h{IH3SUmEh[W6mIIDyc5RmcW5ic4ThZoltcXS7IHnuJIdm\mm2aX7pZk11emWjdHXkJG5US0yFIHPlcIx{ M3u2fFI1OTN6OUCz
MCF-7  M{nObmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHiRZo6OTEEoN88US=> MU[yOOKhcA>? NIPQS|BqdmirYnn0d{B1cGViQ2KxNFgucW6mdXPl[EBk\WyuIHTlZZRp MljKNlQyOjh6NUO=
HPAEpiCs NYG3WY5xTnWwY4Tpc44hSXO|YYm= NYPwWFZpOC5zL{GvNVAh|ryP NYroUFMzOSCq MnTZbY5pcWKrdIOgWG5HNc7zLXnu[JVk\WRiY2DMRVLDqHC{b4TlbY4h[W6mIH3SUmEh\XiycnXzd4lwdg>? NX;4[5NnOjRyNkmxOVg>
podocytes MlvsSpVv[3Srb36gRZN{[Xl? MWqxNOKh|ryP MYixJIg> Mm\rbY5pcWKrdIOgWGdH|rJzLXnu[JVk\WRiYXP0bZZifGmxbjDv[kBxOziPQWDLJIFv\CCHcnuxM|LDqA>? NI\sNVYzPDB|NkKxNi=>
MCF-7 MnjhSpVv[3Srb36gRZN{[Xl? M{nm[FExyqEQvF2= MlvINUBp NXzqfZR{TE2VTx?= MUDy[YR2[2W|IITo[UBYSS2rbnT1Z4VlKHCqb4PwbI9zgWyjdHXkJJA{QCCPQWDL MoLhNlQxOTlyOUC=
MCF-7 MUjGeY5kfGmxbjDBd5NigQ>? MXyxNOKh|ryP NIj6eGozPCCq MX\EUXNQ MXXpcoNz\WG|ZYOgeIhmKFeDLXnu[JVk\WRiYYDvdJRwe2m| MYKyOFAyQTB7MB?=
HAPI MUXGeY5kfGmxbjDBd5NigQ>? MWixNE8zOC92MNMg{txO MUixJIg> NVmxcHc4cW6qaXLpeJMhXEOGRD3pcoR2[2WmIICzPE9LVktiTVHQT{BxcG:|cHjvdplt[XSrb36= NIPZVmQzOzl4OUGyNC=>
HAPI MUXGeY5kfGmxbjDBd5NigQ>? MlTjNlDDqM7:TdMg NIWyUXkyKGh? MmHwSG1UVw>? NYjLcWhT[XS2ZX71ZZRmeyCWQ1TEMYlv\HWlZXSgZYN1cX[jdHnvckBw\iCrTl;TJIFv\CCycn;keYN1cW:w NXjKRVBKOjN7NkmxNlA>
HepG2 MYrGeY5kfGmxbjDBd5NigQ>? MV[zOVAhdk1? NHHXUnIzPCCq Mm\pbY5pcWKrdIOgeIhmKGSnZ4XlcIlvNWmwZIXj[YQh[WO2aY\heIlwdiCxZjDwN|hOSVCN MVOyN|k{OzF7OB?=
AGS  NHeyS5JHfW6ldHnvckBCe3OjeR?= NE\OW4EyOMLizszN NH7z[FY{OCCvaX6= MoPlbY5pcWKrdIOgZ4F{eGG|ZT2zJIFkfGm4YYTpc44h[W6mIHnubIljcXSrb36gc4YhTVKN M3PHW|I{QDVyOUm0
HepG2 NWPBS5g5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonKNE02OCEQvF2= NEHDcng1QCCq MkG4bY5pcWKrdIOgeIhmKHC{b3zp[oVz[XSrb36gbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK= M37CZ|I{QDB5NUC4
BEL7404 NYHLO3l7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7Jb4trOC13MDFOwG0> M3vrdFQ5KGh? NYL5UlczcW6qaXLpeJMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZI> NFPhblIzOzhyN{WwPC=>
HL7702 NEjFUpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLre2JJOC13MDFOwG0> MUC0PEBp MmXjbY5pcWKrdIOgeIhmKHC{b3zp[oVz[XSrb36gbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK= MUOyN|gxPzVyOB?=
HepG2 Mm\DSpVv[3Srb36gRZN{[Xl? M4PFdVAuPTBizszN M4j0elI1KGh? M4Lk[olvcGmkaYTzJJRp\SCyaH;zdIhwenmuYYTpc44hd2ZicEO4JIRwf26|dILlZY0heHKxdHXpcpMhVUGSS1HQT|ItKEGWRkKsJG1UUzFiYX7kJGhUWDJ5IHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ MlvoNlM5ODd3MEi=
BEAS-2B NHjCVo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PsdlExKM7:TR?= Mm[0N|AhdWmw Mn\pdoV3\XK|ZYOgeIhmKGSnY4LlZZNmKG:oIHPlcIwhfmmjYnnsbZR6KGmwZIXj[YQh[nliSFPJ M3XZSFI{Pzh2MEO0
BEAS-2B MnzSR5l1d3SxeHn0fUBCe3OjeR?= NGSw[JEyOCEQvF2= MlHqN|AhdWmw NHvGUXBqdmirYnn0[YQhfGinIHnuZ5Jm[XOnIHnuJGxFUCCjbnSgTWwuQCCneIDy[ZN{cW:w MofvNlM4QDRyM{S=
BEAS-2B M{j6WWZ2dmO2aX;uJGF{e2G7 NUfZOYdrOTBizszN M1T2TVMxKG2rbh?= NXrHc41Q\GWlcnXhd4V{KHSqZTDs[ZZmdHNib3[gZ4F{eGG|ZT2zMEBD[WRiYX7kJIZiew>? Ml\TNlM4QDRyM{S=
H9c2  MUHGeY5kfGmxbjDBd5NigQ>? M2DJOFAvODFxMD6xM|Eh|ryP MYOxJIg> MVrheJRmdnWjdHXzJHRPTi4QsT3pcoR2[2WmIF3NVE06KGW6cILld5Nqd25uIH3SUmEhdGW4ZXzzMEBidmRicILvcY91\XJiYXP0bZZqfHl? NUXoepNWOjN5N{SyOVI>
H9c2  MnHMSpVv[3Srb36gRZN{[Xl? NFr6XlYyKM7:TR?= NFr3XGQyKGh? NFzJOWZz\WS3Y3XzJHRPTi4QsTDkbZJm[3SueTDzeIlufWyjdHXkJJA{QCCPQWDLJJBpd3OyaH;yfYxifGmxbh?= MYOyN|c4PDJ3Mh?=
U937 MmnqSpVv[3Srb36gRZN{[Xl? NVHGNnZFOTEEoN88UeKh M3PZN|EhcA>? MUnhZpJw\2G2ZYOgeIhmKGOjZn\lbY5mKGWoZnXjeEBwdiCPS2CtNUBidmRiUGCyRYPPuSCvUl7BJJRz[W6|Y4LpdJRqd26jbDDs[ZZmdHN? MnHlNlM4ODd|OEe=
U937 NWTZRnBUTnWwY4Tpc44hSXO|YYm= M{njdFExyqEQvF5CpC=> MknQNUBp MX7hZpJw\2G2ZYOgZ4Fn\mWrbnWtbY5lfWOnZDDNT3AuOSCmb4fuMZJm\3WuYYTpc44h[W6mIGDQNmFk|rFidYCtdoVofWyjdHnvci=> MYOyN|cxPzN6Nx?=
U937 MkHMSpVv[3Srb36gRZN{[Xl? NYPMe4YyOTEEoN88UeKh NIDOcGwyKGh? MkXTd5VxeHKnc4Pld{BkNUq3bjDhcoQhS1KHQjDwbI9{eGixconsZZRqd25iaX6gZ4Fn\mWrbnWteJJm[XSnZDDj[Yxte8Li Mkn3NlM4ODd|OEe=
A549 NEDD[IZHfW6ldHnvckBCe3OjeR?= NXLBXpZCOC5|L{OvN|Ah|ryP NFv5bmIyKGh? Mmjsd4lodmmoaXPhcpRtgSCjdITlcpVifGW|IFHUVO6{Wy2vZXTpZZRm\CCFT2itNkBxem:2ZXnuJIFv\CCvUl7BJIV5eHKnc4Ppc44h[W6mIIDyc41wfGW{IHHjeIl3cXS7wrC= MVeyN|Y5ODZ5NB?=
A549 NHLhR|RHfW6ldHnvckBCe3OjeR?= NXLaeFhzOTEEoN88UeKh NEDlNVExNTNyIH3pci=> MmXPbY5pcWKrdIOgRXRR|rOVIHnu[JVk\WRicESyM5A1PCCPQWDLJIFv\CCyM{igUWFRUyCyaH;zdIhwenmuYYTpc44> NUTmflZPOjN4OEC2O|Q>
A549 NXnTV|k{TnWwY4Tpc44hSXO|YYm= NXfhc4Q6OTEEoN88UeKh NHrLcVUyKGh? NHzIXnRqdmirYnn0d{BCXFEQs2OgbY5lfWOnZDDOSk3PwkJicE[1JJN2[nWwaYSgdIhwe3Cqb4L5cIF1cW:wIHHu[EBPTi4QulKgdJJwdW:2ZYKgZYN1cX[rdIm= M{XaN|I{PjhyNke0
A549 NETTfFFHfW6ldHnvckBCe3OjeR?= M1jPcVExyqEQvF5CpC=> NFvnUGIyKGh? NHuwZ5pz\WS3Y3XzJGFVWM7|Uz3zeIlufWyjdHXkJINRVEF{IIDoc5NxcG:{eXzheIlwdsLi NGfI[28zOzZ6ME[3OC=>
A549 MX;GeY5kfGmxbjDBd5NigQ>? MVGxNOKh|ryPwrC= NX3QWFdFOSCq Mn\odoVlfWOnczDBWHDPu1NvZX7oZY5k\WRiZX76fY1ifGmlIHHjeIl3cXS7IH;mJINRVEF{wrC= NVT3SG1pOjN4OEC2O|Q>
PC12 M{O3[2Z2dmO2aX;uJGF{e2G7 NXTnSpo{OTBxMkCvOFAh|ryP M2L1cVHDqGh? NVrzSZB3cW6qaXLpeJMhUk6NIHHu[EBxOzh? NF\zTGEzOzV6NEO1Oy=>
HK-2 NVLwe4VtSXCxcITvd4l{KEG|c3H5 M3zLRlIxyqEQvF2= NVvQeYdJOjRiaB?= Ml\SbY5pcWKrdIOgSXJMKGGwZDDwN|hOSVCN Mn;pNlM2PDNzNUG=
H9c2 NUjESVdNTnWwY4Tpc44hSXO|YYm= Mn;iNeKh|ryP NX[wdZlNOSCq M1T3b5Jm\HWlZYOgWG5HNc7zLXnu[JVk\WRiTV3QMVkhdVKQQTDs[ZZmdHNiYX7kJJBzd22xdHXyJIFkfGm4aYT5 MlHFNlM{PTN4OUm=
H9c2 M2fqXWZ2dmO2aX;uJGF{e2G7 MnWzNeKh|ryP MXSxJIg> NYfGNZF1emWmdXPld{BVVkZvzsGt[Y5p[W6lZXSgRXAuOSCycn;tc5RmeiCjY4Tpeol1gQ>? NX;JcllPOjN|NUO2PVk>
H1650  MYjGeY5kfGmxbjDBd5NigQ>? NELaOXoyOMLizszNxsA> MUmxJIg> MkWxSG1UVw>? M1H4doRm[3KnYYPld{Bjd3SqIIDyc5RmcW5iYX7kJI1TVkFibHX2[Yx{KG:oIFXSR2MyKGmwIIDhZ4xqfGG6ZXyt[Zhxd3OnZNMgZ4VtdHN? M4jL[|I{OjJ6Nkm2
H1703 M3;5eWZ2dmO2aX;uJGF{e2G7 NE\VPWsyOMLizszNxsA> NVH3ell[OSCq NVfDdZZ4TE2VTx?= Mn2z[IVkemWjc3XzJIJwfGhicILveIVqdiCjbnSgcXJPSSCuZY\lcJMhd2ZiRWLDR|EhcW5icHHjcIl1[XinbD3lfJBwe2WmwrDj[Yxtew>? MnvqNlMzOjh4OU[=
H1650  M{PVemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYOxNOKh|ryPwrC= NY\M[4sxOSCq M2LHNGROW09? NUfCZ|ky\W6qYX7j[ZMheGGlbHn0ZZhmdC2rbnT1Z4VlKGO7dH;0c5hq[2m2eR?= M4LqVFI{OjJ6Nkm2
H1703 NU\4NpM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXCWGNPOTEEoN88UeKh M2PtVlEhcA>? NVHxfG15TE2VTx?= MW\lcohidmOnczDwZYNtcXSjeHXsMYlv\HWlZXSgZ5l1d3SxeHnjbZR6 MmnZNlMzOjh4OU[=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
mTOR / p-S6K / S6K / p-S6 / p-AKT / p-MK2; 

PubMed: 26844273     


CRC cells were treated with 10 μM SB202190 for 2 h and analyzed for mTOR signaling and on-target inhibition of p38 by immunoblot. 

pJNK1 / pJNK2 / JNK1 / JNK2 ; 

PubMed: 18222647     


A549 cells were treated with DMSO control or with 10 µM of SB202190 for 0.5, 1, 2, 3, 4, or 6 hours, and pJNK and unphosphorylated JNK were detected as described. 

26844273 18222647
Immunofluorescence
p-p38 / MMP9; 

PubMed: 24479681     


Immunocytochemical staining and confocal microscopy confirmed that IL-1β increased activation of p38 (red), and MMP2 and MMP9 (green) expression in MKN-45 GA cells; these effects were blocked by p38 siRNA or the p38 inhibitor SB202190.

24479681
Growth inhibition assay
Cell viability ; 

PubMed: 26844273     


Top panel: CRC cells were treated with various concentrations of SB202190 for 48 h. Lower panel: CRC cells were treated with SB202190 at 10 μM for different times. Cell growth was measured by SRB assay (means ± s.d. in triplet, n = 3 in triplet).

26844273
体内研究

SB 202190通过抑制p38减弱了由人脊髓灰质炎IgG(PV-IgG)在被动转移小鼠模型中诱发的水泡形成[5]。在脓毒症内毒素模型中,与对照组相比,经SB 202190处理可显著提高存活率[8]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

体外酶活检测:

p38α 和 p38β 溶解在25mM的Tris - HCl缓冲液中,PH 7.5,含0.1mM EGTA,髓鞘碱性蛋白(0.33毫克/毫升)作为底物。人工操作条件用50μL [γ-33P]ATP于30 °C孵育10分钟;Biomek 2000自动化工作站用25μL [γ-33P]ATP在96孔板室温孵育40分钟。ATP和乙酸镁浓度分别为0.1mM和10mM。所有检测都用MgATP起始。人工检测将孵育液滴到磷酸纤维素纸上,浸泡在50mM磷酸中。用5μL磷酸终止反应,后将孵育液点滴在P30过滤垫上。滤膜在50mM磷酸中漂洗四次以去除ATP,在用丙酮(人工孵育)或甲醇(工作站孵育)处理后,干燥并用放射性计量。
细胞实验:

[2]

- 合并
  • Cell lines: Jurkat, 和 HeLa细胞
  • Concentrations: 溶解于DMSO, 终浓度~50 μM
  • Incubation Time: 24 小时
  • Method:

    细胞血清饥饿后,用不同浓度SB 202190处理24小时。用台盼蓝或PI染色后经流式细胞仪分析,以检测细胞活力。凋亡细胞核用H33258染色。


    (Only for Reference)
动物实验:

[5]

- 合并
  • Animal Models: C57BL/6J 小鼠皮内注射无菌的对照IgG或人脊髓灰质炎IgG做对比。
  • Dosages: 12.5 μg
  • Administration: 皮内注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 66 mg/mL (199.19 mM)
Ethanol 12 mg/mL (36.21 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5%DMSO+40%PEG300+5%Tween80+50%H2O
8 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 331.34
化学式

C20H14N3OF

CAS号 152121-30-7
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID