Carfilzomib (PR-171)
中文名称：卡非佐米
Carfilzomib (PR-171) 是一种不可逆proteasome抑制剂，在ANBL-6细胞中IC50为<5 nM，在体外优先抑制β5亚基的ChT-L活性，对PGPH和T-L活性很弱或没有作用。Carfilzomib 可激活自噬并诱导细胞凋亡。
Carfilzomib (PR-171) Chemical Structure
CAS: 868540-17-4
相关Proteasome产品
客户使用Selleck的Carfilzomib (PR-171)发表文献190篇：
产品质控
批次：
纯度：
99.75%
99.75
Proteasome抑制剂选择性比较
细胞实验数据示例
| 细胞系 | 实验类型 | 给药浓度 | 孵育时间 | 活性描述 | 文献信息 |
|---|---|---|---|---|---|
| MM.1S | NXO5V2RFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= | NVLDbFdFOC1zMECgcm0> | MXW0PEBp | NXnkPIFGUUN3MNMgQeKhOTBibl2= | MkKyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|MUK1OFMoRjJ3M{GyOVQ{RC:jPh?= |
| NCI-H929 | NFn1cGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= | NUfpUVJNOC1zMECgcm0> | MWm0PEBp | NIe4T2RKSzVyIE5CpFE1KG6P | NYrsXnRZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNVI2PDNpPkK1N|EzPTR|PD;hQi=> |
| SUDHL16 | MlHlRZBweHSxc3nzJGF{e3OjeR?= | MWSyMlXjiJN|LkWgcm0> | MmDjOFghcA>? | NE\VXplmdmijbnPld{B1cGViY3XscEBl\WG2aDDjc{11emWjdH3lcpQhf2m2aDDBR3kyOjF3 | M2HaVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MkO5PVM2Lz5{NUKzPVk{PTxxYU6= |
| SUDHL14 | MorURZBweHSxc3nzJGF{e3OjeR?= | NYXxdYllOi534pETN{42KG6P | M{Pnb|Q5KGh? | Mn\J[Y5p[W6lZYOgeIhmKGOnbHyg[IVifGhiY3:teJJm[XSvZX70JJdqfGhiQVPZNVIyPQ>? | NELBXJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKzPVk{PSd-MkWyN|k6OzV:L3G+ |
| U2932 | M3TBVWFxd3C2b4Ppd{BCe3O|YYm= | MlLmNk426oDVMz61JI5O | NYLMPIRpPDhiaB?= | M3naWYVvcGGwY3XzJJRp\SClZXzsJIRm[XSqIHPvMZRz\WG2bXXueEB4cXSqIFHDXVEzOTV? | NF;tOI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKzPVk{PSd-MkWyN|k6OzV:L3G+ |
| P-UMSCC-1 | MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? | NVjvNZc4UUN3ME2xNU4zKG6P | MoXuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MUWwN|koRjJ2OUG1NFM6RC:jPh?= | ||
| R-UMSCC-1 | M1\Gdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 | NUfEVnhHUUN3ME2yNlk1KG6P | NInOSJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmxOVA{QSd-MkS5NVUxOzl:L3G+ | ||
| P-Cal33 | NGD0ZZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= | M{LvXmlEPTB;MUeuN{BvVQ>? | MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlzNUCzPUc,OjR7MUWwN|k9N2F- | ||
| R-Cal33 | NEHTT|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= | MlrPTWM2OD1zMUGyJI5O | Mk\IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MUWwN|koRjJ2OUG1NFM6RC:jPh?= | ||
| Jurkat | MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? | MYmxMVEydk1? | M3n3fFQ5KGh? | NEPndmVqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHPvMZRz\WG2bXXueEB4cXSqII\vdolvd3O2YYS= | MmPoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6MEGxNlgoRjJ2OECxNVI5RC:jPh?= |
| Jurkat | NWTCOZRMSXCxcITvd4l{KEG|c4PhfS=> | NVvmZZZRQCCwTR?= | MlnXNlQwPDhiaB?= | M4PwSolv\HWlZYOgZZBweHSxc3nzMEBk[XOyYYPlJIFkfGm4YYTpc44tKGGwZDDQRXJRKGOuZXH2ZYdmKGOxLYTy[YF1dWWwdDD3bZRpKH[xcnnuc5N1[XR? | MnO0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6MEGxNlgoRjJ2OECxNVI5RC:jPh?= |
| UMSCC-22A | NEPa[opCeG:ydH;zbZMhSXO|c3H5 | MnS2NlAxKG6P | MnLONlQhcA>? | NFPmXohqdmS3Y3WgeIhmKGOnbHygZZBweHSxc3nzJINwNXS{ZXH0cYVvfCC5aYToJG9PYCByOUGy | NUixfFZ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5Nlk5ODNpPkKyPVI6QDB|PD;hQi=> |
| UMSCC-22B | NYH1fVFTSXCxcITvd4l{KEG|c4PhfS=> | NXfqUWJCOjByIH7N | NFjaVlkzPCCq | M4fqdIlv\HWlZTD0bIUh[2WubDDhdI9xfG:|aYOgZ48ufHKnYYTt[Y51KHerdHigU25ZKDB7MUK= | MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl{OUiwN{c,OjJ7Mkm4NFM9N2F- |
| 1483 | MlSyRZBweHSxc3nzJGF{e3OjeR?= | NXfVXmc{OjByIH7N | M1yycVI1KGh? | NXvFWpQ5cW6mdXPlJJRp\SClZXzsJIFxd3C2b4Ppd{Bkdy22cnXheI1mdnRid3n0bEBQVlhiMEmxNi=> | NFrJcoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmyPVgxOyd-MkK5Nlk5ODN:L3G+ |
| UMSCC-1 | M2LCSWFxd3C2b4Ppd{BCe3O|YYm= | NFW2dI4zODBibl2= | MlO0NlQhcA>? | MU\pcoR2[2VidHjlJINmdGxiYYDvdJRwe2m|IHPvMZRz\WG2bXXueEB4cXSqIF;OXEAxQTF{ | MnjLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7Mkm4NFMoRjJ{OUK5PFA{RC:jPh?= |
| UMSCC-22A | MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? | M3vpemlEPTB;M{iuO{DDuSBzLkCgcm0> | MnvLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7Mkm4NFMoRjJ{OUK5PFA{RC:jPh?= | ||
| UMSCC-22B | NIjwTINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= | NY\1RpZ5UUN3ME2zNE44KMLzIEmuN{BvVQ>? | M1HjflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUK5PFA{Lz5{MkmyPVgxOzxxYU6= | ||
| 1483 | MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? | MVXJR|UxRTVyLkWgxtEhOTFwOTDuUS=> | NXrwW2p{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5Nlk5ODNpPkKyPVI6QDB|PD;hQi=> | ||
| UMSCC-1 | MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? | MVfJR|UxRTN2Lk[gxtEhOi54IH7N | NIrWcoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmyPVgxOyd-MkK5Nlk5ODN:L3G+ | ||
| Cal33 | NVrSZXM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= | Mn3XTWM2OD12OT6zJOKyKDhwOTDuUS=> | NH7GNoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmyPVgxOyd-MkK5Nlk5ODN:L3G+ | ||
| PCI-15A | Mn3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? | MXLJR|UxRTdyLkSgxtEhOjJwNjDuUS=> | MlGzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7Mkm4NFMoRjJ{OUK5PFA{RC:jPh?= | ||
| PCI-15B | NEXrfppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= | NXXYT3pOUUN3ME2zPU42KMLzIEGxMlAhdk1? | M4e1W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUK5PFA{Lz5{MkmyPVgxOzxxYU6= | ||
| OSC-19 | MljJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? | MYnJR|UxRTF6LkOgxtEhPC5{IH7N | MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl{OUiwN{c,OjJ7Mkm4NFM9N2F- | ||
| SUDHL16 | MXHBdI9xfG:|aYOgRZN{e2G7 | NGL6[XAzNjBvND6wJI5O | MUi0PEBp | MmHubY5lfWOnczDj[YxtKGSnYYToJINwNXS{ZXH0cYVvfCC5aYToJI9j[XSxY3zhfC=> | M4HjelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEGxPFk6Lz5{MkSxNVg6QTxxYU6= |
| SUDHL16 | MXrGeY5kfGmxbjDBd5NigQ>? | M1G2UFIvPSCwTR?= | MmrPNlQhcA>? | NYP0dHBD[WO2aY\heIV{KEqQSzygbY5i[3SrdnH0[ZMhSUuWLDD1dE1z\We3bHH0[ZMhVm:6YTygZY5lKGmwZIXj[ZMh|rOKMlGuXEBkdy22cnXheI1mdnRid3n0bEBw[mG2b3PsZZg> | MnfBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2MUG4PVkoRjJ{NEGxPFk6RC:jPh?= |
| Granta | MnvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? | MYiwMVQhdk1? | NXjnRXRLPDhiaB?= | NELON45qdmS3Y3WgZ4VtdCCmZXH0bEBkdy22cnXheI1mdnRid3n0bEBJSUSFSYO= | NIS3NFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUe1NFIzPCd-MkG3OVAzOjR:L3G+ |
| SUDHL16 | M3\Md2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 | Mme4NU01KG6P | NF;pbnk{PiCq | M{O0dolv\HWlZTDj[YxtKGSnYYToJINwNXS{ZXH0cYVvfCC5aYToJGhCTEOLcx?= | MmjmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB{M{O5O|MoRjJyMkOzPVc{RC:jPh?= |
| MOLT4 | MVXGeY5kfGmxbjDhd5NigQ>? | NITvSWUyKGi{ | NIf0N2xKdmirYnn0bY9vKG:oIHPofY1wfHK7cIPpck1tcWunIHHjeIl3cXS7IH;mJFIxWyCycn;0[YF{d22nIHnuJIh2dWGwIF3PUHQ1KGOnbHzzJIFnfGW{IEGgbJIh[nliQ3XscHRqfGW{LVfsc{BtfW2rbnXzZ4VvfCCjc4PhfUwhUUN3MDC9JFAvODB3MTFOwG0v | MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN2OES3N{c,OTl|NEi0O|M9N2F- | |
| MESSA | MYfDfZRwfG:6aXPpeJkh[XO|YYm= | MlnpO|IhcHK| | MlniR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWVUW0FiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTldk1IdG9ibIXtbY5me2OnboSgZZN{[XluIFnDOVAhRSByLkCxPEDPxE1w | MlH3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|NEi0O|MoRjF7M{S4OFc{RC:jPh?= | |
| MESSA | NVTjcm83S3m2b4TvfIlkcXS7IHHzd4F6 | NUjUeo5LPzJiaILz | MlrUR5l1d3SxeHnjbZR6KGGpYXnud5QhdXWudHnkdpVoKHKnc3nzeIFv[2VidILhcpNxd3K2ZYKg[ZhxemW|c3nu[{Bld3ixcoXibYNqdiC{ZYPpd5RidnRiaIXtZY4hVUWVU1GgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gcJVucW6nc3PlcpQh[XO|YYmsJGlEPTBiPTCwMlQyOyEQvF2u | M{f6XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{S4OFc{Lz5zOUO0PFQ4OzxxYU6= | |
| RPMI8226 | MVTDfZRwfG:6aXPpeJkh[XO|YYm= | NEDLRnU4OiCqcoO= | MnTCR5l1d3SxeHnjJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUmDNTVgzOjZiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VWyCjc4PhfUwhUUN3MDC9JFAvODF|MUmg{txONg>? | NX\JNVlTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3Olc5OThpPkK0O|Y4QDF6PD;hQi=> | |
| NCI-H929 | M{PIdWN6fG:2b4jpZ4l1gSCjc4PhfS=> | MnTqO|IhcHK| | MWPDfZRwfG:6aXOgZYN1cX[rdImgZYdicW6|dDDoeY1idiCQQ1mtTFkzQSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRUKGG|c3H5MEBKSzVyIE2gNE4xOjF|MjFOwG0v | MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd4N{ixPEc,OjR5Nke4NVg9N2F- | |
| CCRF-CEM | MVLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? | NGqzWJI4OiCqcoO= | NHuw[2RCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPDVmYuS0WPIHPlcIx{KGGodHXyJFczKGi{czDifUBwgHmudXPp[oVzcW5ibIXtbY5me2OnbnPlJIF{e2G7LDDJR|UxKD1iMD6wNFYyKM7:TT6= | MmLXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{M{GxOlIoRjJ4MkOxNVYzRC:jPh?= | |
| RPMI8266 | MVzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? | NX2xcZVIPzJiaILz | NHj4UYlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGLQUWk5OjZ4IHPlcIx{KGGodHXyJFczKGi{czDifUBwgHmudXPp[oVzcW5ibIXtbY5me2OnbnPlJIF{e2G7LDDJR|UxKD1iMD6wNVM6KM7:TT6= | M1PRR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkOxNVYzLz5{NkKzNVE3OjxxYU6= | |
| HCT116 | MnyzRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? | NX;rdJJWPzJiaILz | MkP5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IH;4fYx2[2moZYLpckBtfW2rbnXzZ4Vv[2ViYYPzZZktKEmFNUCgQUAxNjBzOUOg{txONg>? | M125b|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkOxNVYzLz5{NkKzNVE3OjxxYU6= | |
| A431 | NHj3XZlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= | MU[3NkBpenN? | MoTORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNEOxJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCxeInseYNq\mW{aX6gcJVucW6nc3PlcoNmKGG|c3H5MEBKSzVyIE2gNE4xOjN6IN88UU4> | Mn7iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{M{GxOlIoRjJ4MkOxNVYzRC:jPh?= | |
| TOV21G | MYLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? | NIjpSFc4OiCqcoO= | M{DHPWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iVF;WNlFIKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDvfJltfWOrZnXybY4hdHWvaX7ld4NmdmOnIHHzd4F6NCCLQ{WwJF0hOC5yMkO4JO69VS5? | NYnHV2xNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yN|EyPjJpPkK2NlMyOTZ{PD;hQi=> | |
| RKO | MVjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? | NXX5eFhZPzJiaILz | NH7lPVBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGLLU{Bk\WyuczDh[pRmeiB5MjDodpMh[nlib4j5cJVkcW[ncnnuJIx2dWmwZYPj[Y5k\SCjc4PhfUwhUUN3MDC9JFAvODJ5MTFOwG0v | MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ|MUG2Nkc,OjZ{M{GxOlI9N2F- | |
| MM1S | NXvHSYc1SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= | M4Lub|czKGi{cx?= | NH7sS45CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3NNXMh[2WubIOgcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OCB;IECuNFAyPSEQvF2u | NI\mNm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e2OVQxQCd-Mke3OlU1ODh:L3G+ | |
| RPMI8226 | MYjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? | NYD2XXF4PzJiaILz | M3q5PWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUmDNTVgzOjZiY3XscJMhdWWjc4Xy[YQh[W[2ZYKgO|IhcHK|IHL5JG1VWyCjc4PhfUwhUUN3MDC9JFAvODF|MjFOwG0v | MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd4NUSwPEc,Ojd5NkW0NFg9N2F- | |
| LCL | M1f4ZmN6fG:2b4jpZ4l1gSCjc4PhfS=> | NIXINZE1QCCqcoO= | MkjLR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUGNNKGOnbHzzJIhiemKxcnnu[{B4cWymIIT5dIUheDV|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgO2FCTC2|dHHpcolv\yCkYYPl[EBHSUOVIHHuZYx6e2m|LDDMSFUxKD1iMD6wN{DPxE1w | MnTHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7OUS3N|QoRjJ5OUm0O|M1RC:jPh?= | |
| RD-ES | NVzneWRnS3m2b4TvfIlkcXS7IHHzd4F6 | M2nmPVQ5KGi{cx?= | NWXNTpB2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWkRvRWOgZ4VtdHNiaHHyZo9zcW6pIIC1N{BufXSjboSgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUA4SUGGLYP0ZYlvcW6pIHLhd4VlKE[DQ2OgZY5idHm|aYOsJGxFPTBiPTCwMlA1OyEQvF2u | M2DubFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUm0O|M1Lz5{N{m5OFc{PDxxYU6= | |
| U266 | NITj[ZVEgXSxdH;4bYNqfHliYYPzZZk> | M1LvUlQ5KGi{cx?= | MV3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVNlY3KGOnbHzzJIhiemKxcnnu[{BufXSjboSgdFU{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliN1HBSE1{fGGrbnnu[{Bj[XOnZDDGRWNUKGGwYXz5d4l{NCCOREWwJF0hOC5yNjFOwG0v | M4f0d|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUm0O|M1Lz5{N{m5OFc{PDxxYU6= | |
| WE68 | NWDrUWFUS3m2b4TvfIlkcXS7IHHzd4F6 | NFmyRm41QCCqcoO= | NHjCNo5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBYTTZ6IHPlcIx{KGijcnLvdolv\yC5aXzkJJR6eGVicEWzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhP0GDRD3zeIFqdmmwZzDiZZNm\CCIQVPTJIFv[Wy7c3nzMEBNTDVyIE2gNE4xQCEQvF2u | MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl7NEezOEc,Ojd7OUS3N|Q9N2F- | |
| IMR90 | MmfSR5l1d3SxeHnjbZR6KGG|c3H5 | NXXBdIJlPDhiaILz | NXuySllwS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUU2UOUCgZ4VtdHNiaHHyZo9zcW6pIIfpcIQhfHmyZTDwOVMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSB5QVHEMZN1[WmwaX7nJIJie2WmIF\BR3Mh[W6jbInzbZMtKEyGNUCgQUAxNjF|IN88UU4> | MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl7NEezOEc,Ojd7OUS3N|Q9N2F- | |
| MCF10A | NVrE[Y06S3m2b4TvfIlkcXS7IHHzd4F6 | MmrlOFghcHK| | Ml7RR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHOTCDIHPlcIx{KGijcnLvdolv\yC5aXzkJJR6eGVicEWzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhP0GDRD3zeIFqdmmwZzDiZZNm\CCIQVPTJIFv[Wy7c3nzMEBNTDVyIE2gNE4{OiEQvF2u | MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl7NEezOEc,Ojd7OUS3N|Q9N2F- | |
| SKOV3 | M1zaTWN6fG:2b4jpZ4l1gSCjc4PhfS=> | M33IeVQ5KGi{cx?= | NEDFVZhEgXSxdH;4bYNqfHliYXfhbY5{fCCyNUOg[IVncWOrZX70JIh2dWGwIGPLU3Y{KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhP0GDRD3zeIFqdmmwZzDiZZNm\CCIQVPTJIFv[Wy7c3nzMEBNTDVyIE2gNE4{OiEQvF2u | NHHaSlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m5OFc{PCd-Mke5PVQ4OzR:L3G+ | |
| MDA-MB-468 | NWCxdlQ4S3m2b4TvfIlkcXS7IHHzd4F6 | NXO2NHl1PDhiaILz | NYD5U5hbS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ3QCClZXzsd{Bp[XKkb4LpcochdXW2YX70JJA2OyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IEfBRWQue3SjaX7pcoch[mG|ZXSgSmFEWyCjbnHsfZNqeyxiTFS1NEA:KDBwM{Og{txONg>? | MmLvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7OUS3N|QoRjJ5OUm0O|M1RC:jPh?= | |
| HNDF | MkW0R5l1d3SxeHnjbZR6KGG|c3H5 | MkD6OFghcHK| | NEL6[GREgXSxdH;4bYNqfHliYXfhbY5{fCCKTlTGJINmdGy|IHjhdoJwemmwZzD3bYxlKHS7cHWgdFU{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliN1HBSE1{fGGrbnnu[{Bj[XOnZDDGRWNUKGGwYXz5d4l{NCCOREWwJF0hOC5|NTFOwG0v | MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl7NEezOEc,Ojd7OUS3N|Q9N2F- | |
| KGN | M1vQWmN6fG:2b4jpZ4l1gSCjc4PhfS=> | MnnoOFghcHK| | MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLS24h[2WubIOgbIFz[m:{aX7nJJdqdGRidInw[UBxPTNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTC3RWFFNXO2YXnubY5oKGKjc3XkJGZCS1NiYX7hcJl{cXNuIFzEOVAhRSByLkS1JO69VS5? | MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl7NEezOEc,Ojd7OUS3N|Q9N2F- | |
| MCF7 | M4Prc2N6fG:2b4jpZ4l1gSCjc4PhfS=> | NXnhVVMzPDhiaILz | NXjRSpdlS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCqYYLic5Jqdmdid3ns[EB1gXCnIIC1N{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KDeDQVStd5RicW6rbnegZoF{\WRiRlHDV{BidmGueYPpd{whVER3MDC9JFQvPSEQvF2u | MkPhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7OUS3N|QoRjJ5OUm0O|M1RC:jPh?= | |
| MCF7 | M2HzO2Z2dmO2aX;uJIF{e2G7 | MVuzOUBvVQ>? | NUjrN|ZPPCCqcoO= | NFP4SW1KdmirYnn0bY9vKG:oIEK2V{Bxem:2ZXHzc41mKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKG:oIHjp[4ghdW:uZXP1cIFzKHenaXfoeEBxd2y7dXLpdZVqfGmwLXPvcop2\2G2ZXSgdJJwfGWrboOgZZQhOzVibl2gZYZ1\XJiNDDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz | MlrSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7OUS3N|QoRjJ5OUm0O|M1RC:jPh?= |
| MDA-MB-468 | M1m5c2Z2dmO2aX;uJIF{e2G7 | MYizOUBvVQ>? | NF35cGQ1KGi{cx?= | MWXJcohq[mm2aX;uJI9nKDJ4UzDwdo91\WG|b33lJIlvKGi3bXHuJG1FSS2PQj20Olgh[2WubIOgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIH;mJIhq\2hibX;s[YN2dGG{IIflbYdpfCCyb3z5eYJqeXWrdHnuMYNwdmq3Z3H0[YQheHKxdHXpcpMh[XRiM{Wgcm0h[W[2ZYKgOEBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ | MkW5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7OUS3N|QoRjJ5OUm0O|M1RC:jPh?= |
| MM1S | NYPFeIVSS3m2b4TvfIlkcXS7IHHzd4F6 | NGr5N4c4OiCqcoO= | NIWxc2xEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOVTGVIHPlcIx{KG2nYYP1doVlKGGodHXyJFczKGi{czDifUBOXFNiYYPzZZktKEmFNUCgQUAxNjByMUWg{txONg>? | MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB{N{WzNUc,OjhyMke1N|E9N2F- | |
| RPMI8226 | MkTlR5l1d3SxeHnjbZR6KGG|c3H5 | MUS3NkBpenN? | NX;vVo9VS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWlCPSUiyNlYh[2WubIOgcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OCB;IECuNFE{OiEQvF2u | NGX0[Jc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OECyO|U{OSd-MkiwNlc2OzF:L3G+ | |
| TC32 | Mn75dWhVWyCjc4PhfS=> | NXXtRYlzeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGTDN|Ih[2WubIO= | M2Ljb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6= | ||
| U-2 OS | M{O3UpFJXFNiYYPzZZk> | NIHZ[pNyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiVT2yJG9UKGOnbHzz | NXjPcmlERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=> | ||
| A673 | NVjYZXR2eUiWUzDhd5NigQ>? | M3nydJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCDNkezJINmdGy| | NY\McIlvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=> | ||
| DAOY | M3HWepFJXFNiYYPzZZk> | NGrWPGtyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiRFHPXUBk\Wyucx?= | MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F- | ||
| Saos-2 | MnPRdWhVWyCjc4PhfS=> | M17DW5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVYX;zMVIh[2WubIO= | NHHkN|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+ | ||
| BT-37 | MX;xTHRUKGG|c3H5 | NEDTXFZyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiQmStN|ch[2WubIO= | M4nidlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6= | ||
| RD | NVnoSWVFeUiWUzDhd5NigQ>? | M{DUPJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCURDDj[Yxtew>? | Ml;FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?= | ||
| SK-N-SH | NHuwUppyUFSVIHHzd4F6 | MYPxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3TTEBk\Wyucx?= | Mn7QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?= | ||
| BT-12 | MmTtdWhVWyCjc4PhfS=> | MkXLdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKEKWLUGyJINmdGy| | MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F- | ||
| MG 63 (6-TG R) | M3jFZpFJXFNiYYPzZZk> | MorOdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKE2JIE[zJEg3NVSJIGKpJINmdGy| | NX\FToZDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=> | ||
| NB1643 | M3zOdJFJXFNiYYPzZZk> | NUj2S4h3eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IF7CNVY1OyClZXzsdy=> | NU\vWYt7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=> | ||
| OHS-50 | MUPxTHRUKGG|c3H5 | MXXxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhV0iVLUWwJINmdGy| | MnX1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?= | ||
| BT-12 | NULxV215eUiWUzDhd5NigQ>? | MV7xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDCWE0yOiClZXzsdy=> | MkTqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?= | ||
| LAN-5 | NGH5eIRyUFSVIHHzd4F6 | M3fQO5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGxCVi13IHPlcIx{ | NWDrbZZyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=> | ||
| fibroblast cells | NXr5OWhreUiWUzDhd5NigQ>? | MWXxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5Ih[2:wdILvcEBJcCC5aXzkJJR6eGViZnnido9jdGG|dDDj[Yxtew>? | NVrVNFdURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=> | ||
| NB-EBc1 | NY\xdYxbeUiWUzDhd5NigQ>? | M2TwWpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJG5DNUWEY{GgZ4VtdHN? | MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F- | ||
| SK-N-SH | MUjxTHRUKGG|c3H5 | M4T6eJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHNMNU5vU1igZ4VtdHN? | NGDy[4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+ | ||
| Rh41 | MV7xTHRUKGG|c3H5 | M3vic5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCUaESxJINmdGy| | NVXpV|BwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=> | ||
| A673 | NY[5U28yeUiWUzDhd5NigQ>? | MlS5dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgRVY4OyClZXzsd{k> | NELxR4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+ | ||
| Rh30 | NGe5UXNyUFSVIHHzd4F6 | MUnxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhWmh|MDDj[Yxtew>? | NH7GVIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+ | ||
| BT-37 | MoTZdWhVWyCjc4PhfS=> | NWTYcWo1eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhSlRvM{egZ4VtdHN? | M1;EelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6= | ||
| MG 63 (6-TG R) | MoLrdWhVWyCjc4PhfS=> | NYqzOI5LeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhVUdiNkOgLFYuXEdiUjmgZ4VtdHN? | MlLjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?= | ||
| Rh30 | NEHX[m9yUFSVIHHzd4F6 | MoHRdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgVog{OCClZXzsdy=> | M{LVWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6= | ||
| fibroblast cells | MljzdWhVWyCjc4PhfS=> | NUDSeVVKeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5Ih[2:wdILvcEBJcCC5aXzkJJR6eGViZnnido9jdGG|dDDj[Yxtew>? | MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F- | ||
| OHS-50 | M{XodZFJXFNiYYPzZZk> | MoPEdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgU2hUNTVyIHPlcIx{ | NGHoSHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+ | ||
| SK-N-SH | MnftdWhVWyCjc4PhfS=> | NYL3UIVEeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiT4L0bI9od26jbDCzSEB3cWGkaXzpeJkhe2O{ZXXuJIZweiCVSz3OMXNJKGOnbHzz | MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F- | ||
| Daoy | NFX3TolyUFSVIHHzd4F6 | MYrxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBQenSqb3fvcoFtKDOGII\pZYJqdGm2eTDzZ5Jm\W5iZn;yJGRid3liY3XscJM> | NY\RcFh3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=> | ||
| TC32 | NVryOZRIeUiWUzDhd5NigQ>? | NXXJc4FpeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiT4L0bI9od26jbDCzSEBk[XOyYYPlJJNkemWnbjDmc5IhXEN|MjDj[Yxtew>? | NFHlRYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+ | ||
| TC32 | MkXqdWhVWyCjc4PhfS=> | Mn;YdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohV3K2aH;nc45idCB|RDD2bYFjcWyrdImgd4Nz\WWwIH\vdkBVSzN{IHPlcIx{ | NFj6Ro09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+ | ||
| MG 63 (6-TG R) | NHS4T5FyUFSVIHHzd4F6 | MXHxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBQenSqb3fvcoFtKDOGII\pZYJqdGm2eTDzZ5Jm\W5iZn;yJG1IKDZ|IDi2MXRIKFJrIHPlcIx{ | NHzZVoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+ | ||
| SJ-GBM2 | NWTRNW9EeUiWUzDhd5NigQ>? | MV7xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0pvR1LNNkBk\Wyucx?= | NED6Upo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+ | ||
| SK-N-MC | NVn5R|lxeUiWUzDhd5NigQ>? | Mn3PdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tUWMh[2WubIO= | NH7lSJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+ | ||
| NB-EBc1 | M{T4Z5FJXFNiYYPzZZk> | MoXGdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKE6ELVXCZ|Eh[2WubIO= | MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F- | ||
| LAN-5 | MWDxTHRUKGG|c3H5 | NWPHVmROeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IFzBUk02KGOnbHzz | M1Oxe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6= | ||
| Rh18 | MnyzdWhVWyCjc4PhfS=> | MYLxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhWmhzODDj[Yxtew>? | NXzjc2VYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=> | ||
| SK-N-MC | NXrITXVleUiWUzDhd5NigQ>? | NWfkPZZseUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhW0tvTj3NR{Bk\Wyucx?= | NFG4[po9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+ | ||
| SJ-GBM2 | MXTxTHRUKGG|c3H5 | MX7xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDTTk1ISk1{IHPlcIx{ | MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F- | ||
| TC32 | NF32ZoJyUFSVIHHzd4F6 | MoT6dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgWGM{OiClZXzsdy=> | MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F- | ||
| Rh18 | MUfxTHRUKGG|c3H5 | NWPZ[Jo{eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhWmhzODDj[Yxtew>? | NY\IeHg4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=> | ||
| Saos-2 | NU\0XGhweUiWUzDhd5NigQ>? | NG[wVHNyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBU[W:|LUKgZ4VtdHN? | NHT5RYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+ | ||
| SJ-GBM2 | NIO5N|RyUFSVIHHzd4F6 | NHe2cFRyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCRcoToc4dwdmGuIEPEJJZq[WKrbHn0fUB{[3KnZX6g[o9zKFOMLVfCUVIh[2WubIO= | NF24TWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+ | ||
| RD | NUHWfWxOeUiWUzDhd5NigQ>? | NFHO[|dyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCRcoToc4dwdmGuIEPEJJZq[WKrbHn0fUB{[3KnZX6g[o9zKFKGIHPlcIx{ | NYfPR2U3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=> | ||
| ANBL-6 | NUizW3FoTnWwY4Tpc44h[XO|YYm= | NHv4T3BKdmirYnn0bY9vKG:oIEKwV{Bxem:2ZXHzc41mKGGldHn2bZR6KGmwIHj1cYFvKEGQQlytOkBk\WyuczygTWM2OCB;IECuNFEh|ryPLh?= | NF\BZnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[1NlE1Oyd-Mkm2OVIyPDN:L3G+ | ||
| MCF7 | M3PMW2N6fG:2b4jpZ4l1gSCjc4PhfS=> | MojlOFghcHK| | M332WmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODB2MTFOwG0v | MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF4NUO0OEc,OzBzNkWzOFQ9N2F- | |
| MDA-MB-231 | NUPHPVhqS3m2b4TvfIlkcXS7IHHzd4F6 | NHrtRWY1QCCqcoO= | MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkCwOFQh|ryPLh?= | M4rvVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMU[1N|Q1Lz5|MEG2OVM1PDxxYU6= | |
| RPMI8226 | MX7DfZRwfG:6aXPpeJkh[XO|YYm= | MnLHOFghcHK| | Ml60R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVnBOUTh{Mk[gZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMEC2O{DPxE1w | NGDnclk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEG2OVM1PCd-M{CxOlU{PDR:L3G+ | |
| 点击查看更多细胞系数据 | |||||
生物活性
| 产品描述 | Carfilzomib (PR-171) 是一种不可逆proteasome抑制剂，在ANBL-6细胞中IC50为<5 nM，在体外优先抑制β5亚基的ChT-L活性，对PGPH和T-L活性很弱或没有作用。Carfilzomib 可激活自噬并诱导细胞凋亡。 | ||
|---|---|---|---|
| 靶点 |
|
| 体外研究(In Vitro) | ||||
| 体外研究活性 | Carfilzomib抑制多种细胞系和源自患者的肿瘤细胞的增殖，包括多发性骨髓瘤。Carfilzomib诱导内在和外在的凋亡信号传导途径并激活c-Jun N-末端激酶(JNK)。与bortezomib相比，Carfilzomib协同地塞米松(Dex)表现增强的抗MM活性，并克服了bortezomib等药物的抗性。 Carfilzomib有选择地抑制β5亚基的CHT- L活性，在10 nM剂量时抑制超过80％的活性。低剂量Carfilzomib短期处理导致优先结合特异性的β5组成20S蛋白酶体和β5i免疫蛋白酶体亚基。在Carfilzomib刺激的ANBL -6细胞中检测caspase活性，结果显示caspase- 8和caspase -9和caspase-3活性在8小时后大幅增加，和对照8小时后的细胞相比分别增加了3.2 ， 3.9和6.9倍。在carfilzomib处理过的细胞中，线粒体膜的完整性减少到41%(Q1 + Q2)，而在对照细胞中这一比例为75％。[1] 在另一项研究中，Carfilzomib也表现出对血液和实体肿瘤的临床前有效性。[2] Carfilzomib直接一直破骨形成和骨吸收。[3] |
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|---|---|---|---|---|
| 激酶实验 | 酶联免疫吸附试验分析carfilzomib亚基 | |||
| ANBL -6细胞（2 ×106/孔）接种于96孔板中并用Carfilzomib（0.001至10μM）处理 1小时。然后将细胞裂解（20mM的Tris-HCl， 0.5 mM EDTA），并裂解物上清转移到聚合酶链反应（PCR）平板上。使用起始浓度为6 μg/μL处理ANBL - 6细胞得到的裂解物做标准曲线。活性位点探针[生物素-(CH2)4-Leu-Leu-Leu-环氧酮; 20 μM]加入并于室温温育1小时。在细胞裂解液中添加1％十二烷基硫酸钠（SDS）和加热至100℃变性 ，随后在96孔的多屏DV板中每孔和20μL链霉亲和琼脂糖高性能珠混合并孵育1小时。这些珠粒用酶联免疫吸附试验(ELISA)缓冲液（PBS，1％牛血清白蛋白和0.1 ％吐温-20）洗涤细胞，并温育过夜，在4℃在板振荡器上与抗体的蛋白酶体亚基反应。所用抗体包括鼠单克隆抗- β1 ，抗-β2 ，抗β1i和抗β5i ，山羊多克隆抗β2i ，和兔多克隆抗- β5 （针对KLH- CWIRVSSDNVADLHDKYS肽亲和纯化的抗血清）。珠粒洗涤后用以辣根过氧化物酶标记的二羊抗兔，羊抗鼠或兔antigoat抗体温育2小时。洗涤后，将珠粒用SuperSignal ELISA picochemiluminescence底物反应，而后进行荧光检测。荧光信号通过与标准曲线比较转换为μg/mL，表示为抑制相对于对照的％。使用以下nonsigmoidal剂量 - 反应方程生成拟合曲线：Y = Bottom + (Top-Bottom)/(1 + 10̂((LogEC50 − X) × HillSlope))，其中X是浓度的对数， Y是抑制％，EC 50是表示50％的效果的剂量。 | ||||
| 细胞实验 | 细胞系 | WST-1, ANBL-6细胞 | ||
| 浓度 | 100 nM | |||
| 孵育时间 | 1小时 | |||
| 方法 | WST-1被用于确定蛋白酶体抑制剂Carfilzomib对细胞增殖的影响。增殖的抑制作用是与对照细胞比较所得。线性样条函数是用来使用XLfit4软件进行计算半数抑制浓度（IC50）。抗性程度(DOR)的计算公式是IC50（抗性细胞）/ IC50（敏感细胞）。 ANBL-6细胞用100nM carfilzomib短暂处理，洗涤并悬浮于含有5μg/mL JC-1PBS中，它显示出在线粒体电位依赖性积聚。用FACScan分析线粒体膜电位依赖性颜色转变（从525到590 nM），数据用CellQuest软件分析。 |
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| 实验图片 | 检测方法 | 检测指标 | 实验图片 | PMID |
| Western blot | pERK / ERK / pSTAT5 / STAT5 / pPI3K / PI3K caspase-9 / caspase-8 c-PARP / PARP / caspase-3 Bcl-2 / Bcl-Xl / Mcl-1 / Bik / Bim / Bax / Bak Atg5 / Atg12 / Beclin-1 / LC3-II Noxa / Bik / Puma / Mcl-1 EGFR / HER2 / ER alpha / p-Akt(Ser473) / Akt / p-ERK / ERK / p53 BDP1 / HER2(Tyr1248) / HER2(Tyr1221/Tyr1222) / PARP1 / caspase-7 / p53 Mut HLA class I |
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24590311 | |
| Growth inhibition assay | Cell viability |
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27655642 | |
| 体内研究(In Vivo) | ||
| 体内研究活性 |
Carfilzomib适度降低了体内异种移植物模型中肿瘤的生长。在持续或短暂处理下， Carfilzomib有效地降低多发性骨髓瘤细胞活力。 Carfilzomib增加骨小梁体积，减少骨吸收，并提高非肿瘤小鼠的骨形成。[3] |
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|---|---|---|
| 动物实验 | Animal Models | Beige-nude-XID小鼠 |
| Dosages | 2.0 mg/kg | |
| Administration | 静脉注射 | |
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT05552976 | Recruiting | Relapsed or Refractory Multiple Myeloma | Bristol-Myers Squibb | November 15 2022 | Phase 3 |
| NCT05041933 | Recruiting | Hematological Diseases | University Hospital Limoges | September 15 2021 | -- |
| NCT04811508 | Completed | Relapsed Multiple Myeloma | Centre Hospitalier le Mans | August 4 2020 | -- |
化学信息&溶解度
| 分子量 | 719.91 | 分子式 | C40H57N5O7 |
| CAS号 | 868540-17-4 | SDF | Download Carfilzomib (PR-171) SDF |
| Smiles | CC(C)CC(C(=O)C1(CO1)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CCC3=CC=CC=C3)NC(=O)CN4CCOCC4 | ||
| 储存条件(自收到货起) | |||
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体外溶解度 |
DMSO : 100 mg/mL ( 138.9 mM； DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Ethanol : 50 mg/mL Water : Insoluble |
摩尔浓度计算器 |
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体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
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点击购买：
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实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
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常见问题及建议解决方法
问题 1:
How should I prepare solution of Carfilzomib for ongoing in vivo study?
回答：
This compound can be dissolved in 2% DMSO/30% PEG 300/dd H2O at 10 mg/ml as a suspension, and can be dissolved in 2% DMSO/ castor oil at 10 mg/ml as a clear solution.
Proteasome相关信号通路图
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