CHIR-99021 (CT99021) HCl

For research use only. Not for use in humans.

目录号：S2924

CHIR-99021 (CT99021) HCl Chemical Structure

CAS No. 1797989-42-4

CHIR-99021 (CT99021) HCl是CHIR-99021的盐酸盐, 是GSK-3α/β抑制剂，IC50为10 nM/6.7 nM。其对GSK-3的选择性比对Cdc2和ERK2高500倍以上。CHIR-99021 是一种有效的药理性的 Wnt/beta-catenin 信号通路的激活剂。CHIR-99021 可显著地拯救光诱导的 autophagy，并可增强 GR，RORα和自噬相关蛋白等表达。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 2780.99	现货
5mg	RMB 1373.92	现货
25mg	RMB 4650.09	现货
100mg	RMB 8330.15	现货
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客户使用Selleck生产的CHIR-99021 (CT99021) HCl发表文献374篇：

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产品安全说明书

GSK-3抑制剂选择性比较

生物活性

产品描述

靶点

GSK-3β ^[1] (Cell-free assay)	GSK-3α ^[1] (Cell-free assay)
6.7 nM	10 nM

体外研究

CHIR-99021作用于GSK-3比作用于其最接近的同系物CDC2和ERK2，及其他蛋白激酶选择性高500倍。此外，CHIR-99021只与一组22种药理相关的受体微弱结合，且对一组23种非激酶的酶几乎没有抑制活性。CHIR-99021作用于表达胰岛素受体的CHO-IR细胞，诱导糖原合成酶(GS)激活，EC50为0.763 μM。^[1]CHIR-99021(3 μM)作用于3T3-L1前脂肪细胞，除了模拟胰岛素的作用，抑制GSK-3，使胞内游离β-catenin增加1.9倍，模仿经典Wnt信号通路。在分化的前3天，CHIR-99021处理，抑制脂肪细胞分化，IC50为0.3 μM，通过抑制CCAAT/增强子结合蛋白α（C/EBPα）和过氧化物酶体增殖物激活受体γ（PPARγ）的诱导作用。^[2] 不像LiCl和AR-A014418，CHIR-99021处理，即使在高浓度，不会降低INS-1E细胞活力。相反，CHIR-99021增加INS-1E细胞增殖，这种作用具有剂量依赖性，且显著抑制高糖和高棕榈酸诱导的INS-E细胞死亡，这种作用具有浓度依赖性。CHIR-99021浓度低至1 μM，处理离体大鼠胰岛，促进β细胞复制，5 μM CHIR-99021处理，使细胞复制增长2-3倍。^[3]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
NCI-H1581	NUSwO2R3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWXJR\|UxRTlyMD6yN\|Eh\|ryP	MojZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
NCI-H1155	NVLQV\|BVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4XsdGlEPTB;OEG4MlA2QSEQvF2=	MlHmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
BC-3	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF24NHhKSzVyPUiwOU4zODNizszN	M1;PO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
KARPAS-422	NIGxPFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYHDTIVCUUN3ME23PFkvOzF3IN88US=>	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
DEL	NFnYVmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mmj5TWM2OD15MECuPFM5KM7:TR?=	M{HqNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
KM-H2	NIrGVYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH7pWIxKSzVyPU[5PU4xPTlizszN	MoHBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
U-87-MG	NHfWb4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYLqfHhzUUN3ME22PVQvPTh3IN88US=>	M3fzPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-SNU-1	NGfzfYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUjESm15UUN3ME22PVAvOTd{IN88US=>	M3XwTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-SNU-16	M3vwNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M17sW2lEPTB;NkiwMlQ3OiEQvF2=	NED0dlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
TUR	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEW4SWJKSzVyPU[3NU4{OjJizszN	NWTzSoJbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
IM-9	M1XqTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWDqOmt[UUN3ME22OVEvPTRzIN88US=>	M{X3fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
L-363	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2W0OWlEPTB;NkS4MlA3PCEQvF2=	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
NCI-H226	NWrUPZYzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1HtUGlEPTB;NkK4MlM2OyEQvF2=	NXvaeogyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
HT	NIPqR5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M17ER2lEPTB;NkKyMlc5PSEQvF2=	NHq0cnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
KARPAS-45	NF7EdmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWLFUIY6UUN3ME22NVgvOjJzIN88US=>	M4rVelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
ML-2	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWTRR3VJUUN3ME22NFYvPTd7IN88US=>	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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NCI-H510A	Ml3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYHycYt3UUN3ME21NlQvPjl4IN88US=>	NWfhToQzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
NCI-H1436	M{\nXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUjJR\|UxRTV{Mz6wOlQh\|ryP	MmW1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
HL-60	M1vq[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2LQR2lEPTB;NUKyMlkzPCEQvF2=	M1nlOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
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NCI-H1694	Ml3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX\nW4V3UUN3ME21NVIvPDN7IN88US=>	M{TnTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
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RPMI-8402	NXK0TJJGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml;LTWM2OD13MUCuNFIyKM7:TR?=	MnHwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
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CA46	MnW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWrJR\|UxRTVyND60NFch\|ryP	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
EC-GI-10	M{DpfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2\ad2lEPTB;NUCyMlE3QSEQvF2=	NHm1d2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
CPC-N	M4TVNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnPjTWM2OD13MEKuNFY{KM7:TR?=	Ml\CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
RPMI-6666	Mn31S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFjrelNKSzVyPUS5NU4{QThizszN	NHTuTGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
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HDLM-2	Ml\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmP3TWM2OD12OECuPFY6KM7:TR?=	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
NCI-H446	Ml;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV;6TYgzUUN3ME20O\|cvODhizszN	Mke4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
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COR-L279	NVHVdJU6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYfJR\|UxRTR4ND64OFch\|ryP	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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TE-441-T	NUT6dIh[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWnBW5BVUUN3ME20OVcvOTh4IN88US=>	NHXYfFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
KMS-12-PE	NU\NUWNuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkDiTWM2OD12NU[uPFIzKM7:TR?=	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
SCLC-21H	M1\COWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml[zTWM2OD12NUWuOlk6KM7:TR?=	MlSyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
TALL-1	NHu4U2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVvJR\|UxRTR3NT6yPVch\|ryP	NFTlR2U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
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MS-1	NHvEfWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYnXfWJGUUN3ME20OVQvOzh3IN88US=>	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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DMS-79	MlHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2TVXmlEPTB;NES5MlY5KM7:TR?=	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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OCI-AML2	NHHrOI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGrCbmlKSzVyPUG0NU42ODdizszN	NX3oPVFURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
Detroit562	NUfTU417T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnPCTWM2OD1zNEGuOFY3KM7:TR?=	NFPQd\|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
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OAW-42	NVHiXmozT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUjJR\|UxRTF\|Nz64OVYh\|ryP	M3v4cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
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NCI-H1437	M2XRXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX7MZ2I3UUN3ME2xN\|QvPTlizszN	NX22OWZ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
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CP50-MEL-B	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlzVTWM2OD1zM{SuNkDPxE1?	M1LXVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
BB30-HNC	M2G5bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV\JR\|UxRTF\|ND6xNVYh\|ryP	MmnGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
Capan-2	NFv4NI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV\JR\|UxRTF\|Mz65O\|Uh\|ryP	MlfFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
CTB-1	M3HhVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYrOblhqUUN3ME2xN\|IvQDl5IN88US=>	NW\NV3k5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
HT-1080	NXmyVmdwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHu5Xo9KSzVyPUGzNk4zODRizszN	M3;YVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
MFH-ino	NFfYSZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3TwUWlEPTB;MUOxMlEyPCEQvF2=	NWG4NXFDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
VMRC-RCZ	NYCzeZgyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV7hWnNqUUN3ME2xN\|AvOzd3IN88US=>	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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HEC-1	MlzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4DWbmlEPTB;MUK5MlE6QCEQvF2=	NH;GbXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
EB-3	NIPy[ZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3XlVWlEPTB;MUK3MlAyOyEQvF2=	M{P5ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
UMC-11	NGj6NI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVrJR\|UxRTF{Nj6wN\|gh\|ryP	NIi3RmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
NCI-H2087	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlzsTWM2OD1zMkSuNlg{KM7:TR?=	NHvVO3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
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OPM-2	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF7sXVVKSzVyPUGyN{4yPzZizszN	NFjIbHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
HT-29	NF64WGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUXJR\|UxRTF{Mj63O\|gh\|ryP	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
HAL-01	M2nObWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{G3[mlEPTB;MUKyMlQ6QSEQvF2=	NVjhRpg6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
KYSE-140	M1v4cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXXESXhDUUN3ME2xNlIvOTRzIN88US=>	NWDjbI5DRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
HuP-T4	NV7JTmtWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2fYdmlEPTB;MUKxMlU2KM7:TR?=	M1L3cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-N87	MkC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NET2fZhKSzVyPUGyNU4xPDRizszN	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
OVCAR-3	NFK3TZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUPxXY1rUUN3ME2xNVkvQTF3IN88US=>	M3Tl[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
KNS-81-FD	NVLGWFdTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUmxOFI1UUN3ME2xNVkvPDF5IN88US=>	NHmzVXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
SUP-T1	M4LvTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mkj5TWM2OD1zMUiuPVU3KM7:TR?=	MmjrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
SKG-IIIa	M3zFUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWLJR\|UxRTFzOD6xNVYh\|ryP	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
RKO	MljvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGfGWmpKSzVyPUGxO{45QThizszN	M4rIOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
ATN-1	NI\KPWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWDJR\|UxRTFzNz64Nlgh\|ryP	MnXKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
OVCAR-8	NGTZOlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWjJR\|UxRTFzNz62Olgh\|ryP	NXvRO205RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
HCC1599	NF\xem9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYfJR\|UxRTFzNz6xOVYh\|ryP	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
Calu-6	MlzXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWfJR\|UxRTFzNj63PVgh\|ryP	M4K0fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
DMS-273	NIPXOJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NULRTW1uUUN3ME2xNVUvPjF5IN88US=>	NFfIOG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
786-0	NXjzS5c3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmHVTWM2OD1zMUOuOFU{KM7:TR?=	MmnwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
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