CHIR-99021 (CT99021) HCl

For research use only. Not for use in humans.

目录号：S2924

CHIR-99021 (CT99021) HCl Chemical Structure

CAS No. 1797989-42-4

CHIR-99021 (CT99021) HCl是CHIR-99021的盐酸盐, 是GSK-3α/β抑制剂，IC50为10 nM/6.7 nM。其对GSK-3的选择性比对Cdc2和ERK2高500倍以上。CHIR-99021 是一种有效的药理性的 Wnt/beta-catenin 信号通路的激活剂。CHIR-99021 可显著地拯救光诱导的 autophagy，并可增强 GR，RORα和自噬相关蛋白等表达。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 2780.99	现货
2mg	RMB 733.53	现货
5mg	RMB 1373.92	现货
25mg	RMB 4650.09	现货
100mg	RMB 8330.15	现货
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客户使用Selleck生产的CHIR-99021 (CT99021) HCl发表文献320篇：

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产品安全说明书

GSK-3抑制剂选择性比较

生物活性

产品描述

靶点

GSK-3β ^[1] (Cell-free assay)	GSK-3α ^[1] (Cell-free assay)
6.7 nM	10 nM

体外研究

CHIR-99021作用于GSK-3比作用于其最接近的同系物CDC2和ERK2，及其他蛋白激酶选择性高500倍。此外，CHIR-99021只与一组22种药理相关的受体微弱结合，且对一组23种非激酶的酶几乎没有抑制活性。CHIR-99021作用于表达胰岛素受体的CHO-IR细胞，诱导糖原合成酶(GS)激活，EC50为0.763 μM。^[1]CHIR-99021(3 μM)作用于3T3-L1前脂肪细胞，除了模拟胰岛素的作用，抑制GSK-3，使胞内游离β-catenin增加1.9倍，模仿经典Wnt信号通路。在分化的前3天，CHIR-99021处理，抑制脂肪细胞分化，IC50为0.3 μM，通过抑制CCAAT/增强子结合蛋白α（C/EBPα）和过氧化物酶体增殖物激活受体γ（PPARγ）的诱导作用。^[2] 不像LiCl和AR-A014418，CHIR-99021处理，即使在高浓度，不会降低INS-1E细胞活力。相反，CHIR-99021增加INS-1E细胞增殖，这种作用具有剂量依赖性，且显著抑制高糖和高棕榈酸诱导的INS-E细胞死亡，这种作用具有浓度依赖性。CHIR-99021浓度低至1 μM，处理离体大鼠胰岛，促进β细胞复制，5 μM CHIR-99021处理，使细胞复制增长2-3倍。^[3]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
NCI-H1581	M16xRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVLvb\|J1UUN3ME25NFAvOjNzIN88US=>	NEPGeGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
NCI-H1155	M3u5VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Moi3TWM2OD16MUiuNFU6KM7:TR?=	NGrBNFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
BC-3	NF\rbldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYrJR\|UxRThyNT6yNFMh\|ryP	NYfSNHVQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
KARPAS-422	NF71VVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYnJR\|UxRTd6OT6zNVUh\|ryP	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
DEL	MnT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkTVTWM2OD15MECuPFM5KM7:TR?=	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
KM-H2	NIPxXFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWXtZW1FUUN3ME22PVkvODV7IN88US=>	NEThR5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
U-87-MG	NVvkXmZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX7zcGRsUUN3ME22PVQvPTh3IN88US=>	M3zjeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-SNU-1	M4fDcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoHWTWM2OD14OUCuNVczKM7:TR?=	M1W1SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-SNU-16	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlHUTWM2OD14OECuOFYzKM7:TR?=	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
TUR	NHnObGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFWzdZNKSzVyPU[3NU4{OjJizszN	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
IM-9	M4HXTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUPJR\|UxRTZ3MT61OFEh\|ryP	MmG5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
L-363	M3HQNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn3vTWM2OD14NEiuNFY1KM7:TR?=	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
NCI-H226	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFnuZ2pKSzVyPU[yPE4{PTNizszN	NGizSFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
HT	M4n3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHrpflRKSzVyPU[yNk44QDVizszN	M{jRU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
KARPAS-45	NV3PdWxyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXzn[mRuUUN3ME22NVgvOjJzIN88US=>	NEOxb4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
ML-2	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnPLTWM2OD14ME[uOVc6KM7:TR?=	NHTLNmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
LP-1	MorwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml\hTWM2OD14MEOuOVg4KM7:TR?=	NIfsVHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
L-428	NHjBTXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3fsTmlEPTB;NkCwMlY4OSEQvF2=	MoT1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
K052	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHv5WZpKSzVyPUW3PU4zOTNizszN	MnP6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
CAL-148	NH7hO3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnnoTWM2OD13NkWuNFg6KM7:TR?=	NV;rdXpMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
UACC-812	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV;sZ3NzUUN3ME21OVkvOzlzIN88US=>	Mln5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
EW-11	M{jMTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlrjTWM2OD13NUKuN\|k6KM7:TR?=	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
COLO-320-HSR	Ml7YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoXxTWM2OD13NUGuN\|Uh\|ryP	Mn3xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
NCI-H889	NX7U[nprT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4W1V2lEPTB;NUS3MlI{KM7:TR?=	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
EVSA-T	NHXvOHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVjGSlQyUUN3ME21OFMvPjh2IN88US=>	NFvjRlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
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HSC-4	M{LlZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXvJR\|UxRTV\|OT6yPVMh\|ryP	NGOwbnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
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NCI-H522	MnTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYfv[JVuUUN3ME2xPFEvODV7IN88US=>	NV;P[mJmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
SF126	MmfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGn4cINKSzVyPUG3PU41OzJizszN	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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COLO-741	NIq0OJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkLqTWM2OD1zN{euOVYyKM7:TR?=	NYL3Z5VURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
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LNCaP-Clone-FGC	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1L4XmlEPTB;MUe1Mlg3OSEQvF2=	NV7HbXR3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
SW756	MlLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWL1NWZOUUN3ME2xO\|QvQDZ\|IN88US=>	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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SW620	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYT2WWdPUUN3ME2xO\|EvPTN3IN88US=>	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
HUTU-80	NHvnNZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXnrc5c6UUN3ME2xO\|EvODN{IN88US=>	NInKRYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
Daoy	MnjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF7ybJhKSzVyPUG2PU45QTFizszN	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
KYSE-150	MkDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHTQd5pKSzVyPUG2PU43OzZizszN	M2nr[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
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JVM-2	NVPS[Hc5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4nlcWlEPTB;MU[3MlQ2OSEQvF2=	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
OVCAR-5	MljUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoLPTWM2OD1zNkiuN\|A6KM7:TR?=	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
KINGS-1	M3zIOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGXqZnJKSzVyPUG2O{4{PTRizszN	Mli3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
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NCI-H2087	M3jK[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{TWXWlEPTB;MUK0MlI5OyEQvF2=	M3vmNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
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HAL-01	M{T0XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWnvUFFbUUN3ME2xNlIvPDl7IN88US=>	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
KYSE-140	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVLmdnpiUUN3ME2xNlIvOTRzIN88US=>	M4O4cFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
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OVCAR-3	M2LsXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnfYTWM2OD1zMUmuPVE2KM7:TR?=	NU\3PZZ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
KNS-81-FD	MkHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MU\JR\|UxRTFzOT60NVch\|ryP	NIK4NHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
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RKO	MnvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{H4WGlEPTB;MUG3Mlg6QCEQvF2=	M2TxcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
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OVCAR-8	NWHxWY43T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGTzZnFKSzVyPUGxO{43PjhizszN	MkfUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
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Calu-6	NH;3cHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MU\JR\|UxRTFzNj63PVgh\|ryP	Mn;iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
DMS-273	M1fwSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHzV[XBKSzVyPUGxOU43OTdizszN	NWrUZ\|F{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
786-0	M4jhXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEDlUZJKSzVyPUGxN{41PTNizszN	MoWxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
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NEC8	NGXTb3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmXHTWM2OD1zMUKuOlI1KM7:TR?=	M{PlRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
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U031	NFH0d\|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUnW[G5vUUN3ME2xNVIvODZ3IN88US=>	MlzLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
WSU-NHL	M{L5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXXJR\|UxRTFzMj6wNUDPxE1?	NHzIOIs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
HCT-15	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml[zTWM2OD1zMUCuOlYyKM7:TR?=	M{fTXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
A253	Mor0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmnXTWM2OD1zMUCuOFc6KM7:TR?=	NYHBN3J6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
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FTC-133	NHLsV\|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV;JR\|UxRTFyOD60PFgh\|ryP	MnPOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
HOP-92	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkPuTWM2OD1zMEiuOFc2KM7:TR?=	M4\4bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-H23	NFfKVZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWH5RXlsUUN3ME2xNFgvOzV5IN88US=>	NVvJfoQ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
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