Dasatinib Monohydrate

For research use only. Not for use in humans.

目录号:S7782 别名: BMS-354825 Monohydrate 中文名称:达沙替尼一水合物

Dasatinib Monohydrate Chemical Structure

CAS No. 863127-77-9

Dasatinib Monohydrate (BMS-354825)是一种新型有效的多靶点抑制剂,作用于靶点AblSrc 和 c-Kit,IC50分别为 <1 nM,0.8 nM 和 79 nM。

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客户使用Selleck生产的Dasatinib Monohydrate发表文献211篇:

产品安全说明书

Src抑制剂选择性比较

生物活性

产品描述 Dasatinib Monohydrate (BMS-354825)是一种新型有效的多靶点抑制剂,作用于靶点AblSrc 和 c-Kit,IC50分别为 <1 nM,0.8 nM 和 79 nM。
靶点
Abl [1]
(Cell-free assay)
Src [1]
(Cell-free assay)
c-Kit (D816V) [2]
(Cell-free assay)
c-Kit (wt) [2]
(Cell-free assay)
0.6 nM 0.8 nM 37 nM 79 nM
体外研究

Dasatinib比imatinib更有效地抑制表达野生型Bcr-Abl 和Bcr-Abl突变体的Ba/F3细胞的增殖,T315I突变体除外。相对于imatinib,Dasatinib具有双对数(∼325倍)增加的效能。Dasatinib有效抑制野生型Abl激酶和除T315I外小范围的所有突变体。Dasatinib直接靶向作用于所有突变型Abl激酶域,并以浓度依赖的方式抑制自身磷酸化和底物磷酸化。与imatinib相比,Dasatinib对表达野生型Bcr-Abl的细胞表现出325倍的效能。[1] TgE骨髓细胞集落百分数在未处理的孔中为100%,在Dasatinib处理的孔中降低为4.12%。在Dasatinib存在下,WT和TgE骨髓细胞形成的集落百分比在统计学上具有显著差异。LMP2A的表达能够促进B淋巴细胞存活和增殖,这能够被以Lyn 和/或c-Abl激酶为靶点的Dasatinib抑制。[3] Dasatinib治疗抑制一部分甲状腺癌细胞中Src信号,减少生长,并诱导细胞周期阻滞和细胞凋亡。以逐渐增加剂量的纳摩尔级浓度的Dasatinib (0.019 μM到1.25 μM)治疗3天,抑制大约50%的C643,TPC1,BCPAP,和SW1736细胞系生长,而抑制K1细胞系的生长需要更高浓度。10 nM 或50 nM Dasatinib治疗导致BCPAP ,SW1736和 K1细胞中G1期细胞增加9-22%,而S期细胞相应减少7-18%。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
K562 cell M12zNnBzd2yrZnXyZZRqd25iYYPzZZk> NEjGZmM4OiCq NHjpZWJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZYZ1\XJiN{KgbJJ{NCCLQ{WwQVAvODBzIN88US=> M1n1WlE2PjF3NUGy
WiDr cell NE[xOGlRem:uaX\ldoF1cW:wIHHzd4F6 NGDkU|U4OiCq M1TLS2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iV3nEdkBk\WyuczDh[pRmeiB5MjDodpMtKEmFNUC9NE4xPTJizszN MWSxOVYyPTVzMh?=
PC3 cell NGnsTFRRem:uaX\ldoF1cW:wIHHzd4F6 Mk\pO|IhcA>? NVXYWoIzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiN{KgbJJ{NCCLQ{WwQVAvODB7NDFOwG0> NXfqN5J1OTV4MUW1NVI>
MDA-MB-231 cell M4XaPXBzd2yrZnXyZZRqd25iYYPzZZk> M2Li[VczKGh? NXHicYhJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDd{IHjyd{whUUN3ME2wMlAyOiEQvF2= MmjGNVU3OTV3MUK=
M07ep210 cell NVTjb41{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1vhZVQ5KGh? MmPkS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUVA4\XB{MUCgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFt|SG30bJlucWSrbnWgeZB1[WunIHHzd4F6NCCLQ{WwQVAvODdibl2= NVHETGV6OTd7NU[wPFA>
K562 cell MlnJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV:0PEBp MXrHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDbN2hefGi7bXnkbY5mKHWydHHr[UBie3OjeTygTWM2OD1yLkCwNUDPxE1? Mn;lNVc6PTZyOEC=
M07e cell MnjxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3[wblQ5KGh? NWTm[YZQT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVTB5ZTDj[YxteyCjZoTldkA1QCCqcoOgZpkhYzOKXYTofY1q\GmwZTD1dJRic2ViYYPzZZktKEmFNUC9NE4xODF{IN88US=> NWTINnBWOTd7NU[wPFA>
K562 cell NUPYSFVsS3m2b4TvfIlkcXS7IHHzd4F6 MmL1O|IhcA>? M1zhd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHdUXC16IILlZYdmdnRiYnHz[YQhVVSWIHHzd4F6NCCLQ{WwQVEzNjh|IN88US=> MYWyNlIyPzh5Nx?=
U937 cell NYqxV|JCS3m2b4TvfIlkcXS7IHHzd4F6 NW[3OpRCPzJiaB?= MoDZR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVk{PyClZXzsd{Bi\nSncjC3NkBpenNiYomgW3NVNThicnXh[4VvfCCkYYPl[EBOXFRiYYPzZZktKEmFNUC9NVMvPjNizszN MYWyNlIyPzh5Nx?=
K562 cell NIXB[5pRem:uaX\ldoF1cW:wIHHzd4F6 NUX0Smc4PzJiaB?= MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFnDOVA:OC55IH7N MlXKNlM2OjFyMkC=
MDA-MB-435S cell MV3Qdo9tcW[ncnH0bY9vKGG|c3H5 MmGxO|IhcA>? NFfmdmRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi12M{XTJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Oy57IN88US=> NHzjV2szOzV{MUCyNC=>
NCI-H460 cell MV3Qdo9tcW[ncnH0bY9vKGG|c3H5 Ml;FO|IhcA>? M2nscmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg1PjBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME24Mlk6KM7:TR?= NUXnOVFZOjN3MkGwNlA>
NCI-H23 cell NEnrPFJRem:uaX\ldoF1cW:wIHHzd4F6 M1KwPFczKGh? M4nqN2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWgzOyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUKuNlch|ryP M{XrclI{PTJzMEKw
A549 cell Mkf5VJJwdGmoZYLheIlwdiCjc4PhfS=> NYrCeVRbPzJiaB?= MnPvRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OTJwNk[g{txO MWWyN|UzOTB{MB?=
T47D cell MVTQdo9tcW[ncnH0bY9vKGG|c3H5 NY\me3dQPzJiaB?= M1zvWGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iVES3SEBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTBwOTFOwG0> M4rZT|I{PTJzMEKw
HCT116 cell NEf5bJdRem:uaX\ldoF1cW:wIHHzd4F6 M1PCV|czKGh? MmPhRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{LkOg{txO NX;k[nY6OjN3MkGwNlA>
MCF7 cells MmrqVJJwdGmoZYLheIlwdiCjc4PhfS=> MU[3NkBp MnjJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Oi53NzFOwG0> M{LOZlI{PTJzMEKw
RXF 393NL cell NFHRbINEgXSxdH;4bYNqfHliYYPzZZk> MVu0JIRigXN? M4DrWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHJZTiB|OUPOUEBk\WyuczDh[pRmeiB2IHThfZMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\yxiSVO1NF0zOS55IH7N M13aVlI{OjV|MEe0
PRXF DU145 cell M3zwSGN6fG:2b4jpZ4l1gSCjc4PhfS=> NF\oXXM1KGSjeYO= MlX4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVHJZTiCGVUG0OUBk\WyuczDh[pRmeiB2IHThfZMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\yxiSVO1NF0xNjB4MkOg{txO Moe3NlMzPTNyN{S=
LXFA 983L cell MnPzR5l1d3SxeHnjbZR6KGG|c3H5 M17Q[FQh\GG7cx?= MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMXGZCKDl6M1ygZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcoctKEmFNUC9OVYvPSCwTR?= NVi2WIJNOjN{NUOwO|Q>
GXF251L cell MmjCR5l1d3SxeHnjbZR6KGG|c3H5 M{XIOlQh\GG7cx?= NWWyTGFxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hT1iIMkWxUEBk\WyuczDh[pRmeiB2IHThfZMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\yxiSVO1NF0zNjJ3IN88US=> Mnz2NlMzPTNyN{S=
CXF 1103L cell NVTlN5RKS3m2b4TvfIlkcXS7IHHzd4F6 M3jadlQh\GG7cx?= M{PlcWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNZTiBzMUCzUEBk\WyuczDh[pRmeiB2IHThfZMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\yxiSVO1NF01NjN4IN88US=> NVnZb|V{OjN{NUOwO|Q>
PAXF 1657L cell MYLDfZRwfG:6aXPpeJkh[XO|YYm= MkT0OEBl[Xm| NE\GepZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSViIIEG2OVdNKGOnbHzzJIFnfGW{IESg[IF6eyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLDDJR|UxRTBwMUKxJO69VQ>? NUXCblE1OjN{NUOwO|Q>
NCI-H1648 cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIX1ZoZKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVY1QCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMEKwNVEh|ryP M4jVU3NCVkeHUh?=
NCI-H1838 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWSxdY1NUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE5OzhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkOwO|M{KM7:TR?= Ml;2V2FPT0WU
NCI-H2126 cell NVPHNIhFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXzpflhsUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIyOjZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lki3OVUzKM7:TR?= MXfTRW5ITVJ?
NCI-H2141 cell NGDncJpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVHJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkG0NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI1Njd5NUSg{txO M1XJPXNCVkeHUh?=
NCI-H2107 cell NIfyd5hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MU\Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkGwO{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ{NjR6NEeg{txO MVjTRW5ITVJ?
NCI-H747 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2XaTWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi3OFch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB6M{[yJO69VQ>? MXLTRW5ITVJ?
NCI-H720 cell NELSU5pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWrJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KN{KwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlAvOjd|MzFOwG0> MoHHV2FPT0WU
NKM-1 cell MlnoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXjJcohq[mm2aX;uJI9nKGi3bXHuJG5MVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1zLkOwPFU6KM7:TR?= M{\I[3NCVkeHUh?=
NMC-G1 cell M1v3VGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkHqTY5pcWKrdHnvckBw\iCqdX3hckBPVUNvR{GgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNVE3ODZizszN M16xbXNCVkeHUh?=
NTERA-S-cl-D1 cell MnX2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4fCemlvcGmkaYTpc44hd2ZiaIXtZY4hVlSHUlGtV{1kdC2GMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xNlI5OyEQvF2= Mnn5V2FPT0WU
OCI-AML2 cell NVLwU|R3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWPJcohq[mm2aX;uJI9nKGi3bXHuJG9EUS2DTVyyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME21Mlg3OTV2IN88US=> NVvNWG5nW0GQR1XS
OCUB-M cell M4XZOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml7HTY5pcWKrdHnvckBw\iCqdX3hckBQS1WELV2gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGuNFQ1OTJizszN M1nlNnNCVkeHUh?=
OPM-2 cell NHzGVJFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYjJcohq[mm2aX;uJI9nKGi3bXHuJG9RVS1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD12LkK3Olg2KM7:TR?= NXfoV3B3W0GQR1XS
OS-RC-2 cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXrSRXNYUW6qaXLpeIlwdiCxZjDoeY1idiCRUz3SR{0zKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjB{MEOg{txO MV7TRW5ITVJ?
ONS-76 cell MmLES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2fjT2lvcGmkaYTpc44hd2ZiaIXtZY4hV06VLUe2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlQzQTVzIN88US=> M4LJNHNCVkeHUh?=
OVCAR-4 cell NIiySItIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2fPXWlvcGmkaYTpc44hd2ZiaIXtZY4hV1[FQWKtOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4{PzR|MzFOwG0> NF;J[2ZUSU6JRWK=
NCI-H446 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4X3[WlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi0OFYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvPjJ5NjFOwG0> Mo\KV2FPT0WU
NCI-H510A cell M4nadmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYOxZXR2UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFUyOEFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTF7LkO5O|Mh|ryP NIHMb5hUSU6JRWK=
PF-382 cell NWe3VFQyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUXVcGR1UW6qaXLpeIlwdiCxZjDoeY1idiCSRj2zPFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvOTd4N{ig{txO MkjSV2FPT0WU
NCI-H64 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3XEOmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi2OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NlkvPjJ3MzFOwG0> MofSV2FPT0WU
PSN1 cell NY[4WHh[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3[0emlvcGmkaYTpc44hd2ZiaIXtZY4hWFOQMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wOFQ4PCEQvF2= NGnLT|ZUSU6JRWK=
QIMR-WIL cell M{Lz[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVjVU5dIUW6qaXLpeIlwdiCxZjDoeY1idiCTSV3SMXdKVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC55ME[yPUDPxE1? M1Py[XNCVkeHUh?=
RL95-2 cell M1HIbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYPJcohq[mm2aX;uJI9nKGi3bXHuJHJNQTVvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xNFM5KM7:TR?= Mn;BV2FPT0WU
RCC10RGB cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3XhWGlvcGmkaYTpc44hd2ZiaIXtZY4hWkOFMUDSS2Ih[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvPDlzMTFOwG0> MX\TRW5ITVJ?
RKO cell M4fQNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXrIOIlpUW6qaXLpeIlwdiCxZjDoeY1idiCUS1:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuOVI6PjZizszN NHi5RVNUSU6JRWK=
NCI-SNU-16 cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH;jelFKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3TUnUuOTZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRThwNU[xNlgh|ryP M1fSenNCVkeHUh?=
RPMI-6666 cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NILOPHRKdmirYnn0bY9vKG:oIHj1cYFvKFKSTVmtOlY3PiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:Py5{N{C2O{DPxE1? M1mx[nNCVkeHUh?=
NEC8 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUXJcohq[mm2aX;uJI9nKGi3bXHuJG5GSzhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTR2LkOzOkDPxE1? NUHXXHhmW0GQR1XS
RS4-11 cell NYXufFI2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXTJcohq[mm2aX;uJI9nKGi3bXHuJHJUPC1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;Nz62OVc5PyEQvF2= NUTiXm0zW0GQR1XS
RXF393 cell M2K0XGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmjnTY5pcWKrdHnvckBw\iCqdX3hckBTYEZ|OUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFI{PTdizszN MUTTRW5ITVJ?
Raji cell NUXQVXYxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4j6emlvcGmkaYTpc44hd2ZiaIXtZY4hWmGsaTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MUOuO|Q6PyEQvF2= MmjuV2FPT0WU
NOS-1 cell MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYHJcohq[mm2aX;uJI9nKGi3bXHuJG5QWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCwOlEzQSEQvF2= Mnu1V2FPT0WU
SBC-1 cell M1TvU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NI\kflVKdmirYnn0bY9vKG:oIHj1cYFvKFOEQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2xMlU4QTh2IN88US=> MWfTRW5ITVJ?
SF126 cell NEnTcGJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEjIR5RKdmirYnn0bY9vKG:oIHj1cYFvKFOIMUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlM2PDFizszN NGnVXoRUSU6JRWK=
SF539 cell NIHXZ21Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4m5bWlvcGmkaYTpc44hd2ZiaIXtZY4hW0Z3M{mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGzMlg2PTdizszN Mm\DV2FPT0WU
SH-4 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1jOS2lvcGmkaYTpc44hd2ZiaIXtZY4hW0hvNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xPFQyOyEQvF2= NX\vV4ozW0GQR1XS
OMC-1 cell NUG0Xo9ET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4HUU2lvcGmkaYTpc44hd2ZiaIXtZY4hV02FLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUK3MlE1OjJizszN MULTRW5ITVJ?
SIG-M5 cell M3\uXmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUSxcGE6UW6qaXLpeIlwdiCxZjDoeY1idiCVSVetUVUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVkvODJ2OUOg{txO M4njfnNCVkeHUh?=
SJSA-1 cell NHK4WXVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVu1NJV7UW6qaXLpeIlwdiCxZjDoeY1idiCVSmPBMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVgvPzJ6MEWg{txO M{nx[XNCVkeHUh?=
SK-LMS-1 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYK4doQ5UW6qaXLpeIlwdiCxZjDoeY1idiCVSz3MUXMuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:Oy5zMUi4OkDPxE1? MWrTRW5ITVJ?
SK-NEP-1 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3;MZmlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTlXQMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVgvQDlzNUWg{txO NFm1Xm5USU6JRWK=
SKM-1 cell M3TTUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH\UW5pKdmirYnn0bY9vKG:oIHj1cYFvKFONTT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME25MlAyPzN2IN88US=> MoDWV2FPT0WU
SK-PN-DW cell MmHvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH31d|JKdmirYnn0bY9vKG:oIHj1cYFvKFONLWDOMWRYKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0{Pi5zOUSzJO69VQ>? NXrSc2d{W0GQR1XS
SK-UT-1 cell MlLtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVPnV3g6UW6qaXLpeIlwdiCxZjDoeY1idiCVSz3VWE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0zNjF4NkmzJO69VQ>? NXHRcWFnW0GQR1XS
SNB75 cell MmjrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{PiXWlvcGmkaYTpc44hd2ZiaIXtZY4hW06EN{WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFQ1OzVizszN NIL3[odUSU6JRWK=
REH cell NF3CcWRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGHuOGJKdmirYnn0bY9vKG:oIHj1cYFvKFKHSDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MkCuOlM2PyEQvF2= MV;TRW5ITVJ?
SNU-C2B cell NVW2SnJ1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF7r[2tKdmirYnn0bY9vKG:oIHj1cYFvKFOQVT3DNmIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVEvOzB3OEmg{txO MnTGV2FPT0WU
RPMI-8866 cell NGm4U2FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUDZcFZlUW6qaXLpeIlwdiCxZjDoeY1idiCUUF3JMVg5PjZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTF5LkS0OVUh|ryP M4CxfHNCVkeHUh?=
SW872 cell NFzycGlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIfY[nJKdmirYnn0bY9vKG:oIHj1cYFvKFOZOEeyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlA1OTZzIN88US=> MlnnV2FPT0WU
SW962 cell M3\MdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1PlZWlvcGmkaYTpc44hd2ZiaIXtZY4hW1d7NkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNVEzQTJizszN NFXwXmhUSU6JRWK=
SF268 cell M4LzcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVP0[GN5UW6qaXLpeIlwdiCxZjDoeY1idiCVRkK2PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4yPzRyNDFOwG0> MV\TRW5ITVJ?
TE-1 cell NUD3d2plT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4n5fGlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xNFU1KM7:TR?= MmjBV2FPT0WU
8-MG-BA cell M1T0Tmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH3t[oRKdmirYnn0bY9vKG:oIHj1cYFvKDhvTVetRmEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvOTV2NUig{txO NFHuXnFUSU6JRWK=
A101D cell M1\T[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmX0TY5pcWKrdHnvckBw\iCqdX3hckBCOTBzRDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MT6wN|A1OyEQvF2= NEnUcphUSU6JRWK=
A253 cell M4rWSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWTTUFRNUW6qaXLpeIlwdiCxZjDoeY1idiCDMkWzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2zMlc{OjR4IN88US=> NY\hXoJSW0GQR1XS
A3-KAW cell NUjPfoNpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NE\JNmhKdmirYnn0bY9vKG:oIHj1cYFvKEF|LVvBW{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE46QDR3MjFOwG0> NHrjbGhUSU6JRWK=
A4-Fuk cell MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH63bGFKdmirYnn0bY9vKG:oIHj1cYFvKEF2LV\1b{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9N|gvOTByOTFOwG0> M1\FRXNCVkeHUh?=
A388 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUnJcohq[mm2aX;uJI9nKGi3bXHuJGE{QDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMEWwPVUh|ryP NUX4ZYE4W0GQR1XS
ACN cell MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnO3TY5pcWKrdHnvckBw\iCqdX3hckBCS05iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTFwOEKyOVIh|ryP NYjRbIg5W0GQR1XS
A704 cell MnXWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn\PTY5pcWKrdHnvckBw\iCqdX3hckBCPzB2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCxOFkyKM7:TR?= NGj1cplUSU6JRWK=
ALL-PO cell NX[wNIp3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIHGXYxKdmirYnn0bY9vKG:oIHj1cYFvKEGOTD3QU{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NVAvPzl|ODFOwG0> M1XMTXNCVkeHUh?=
ARH-77 cell M{DEd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml74TY5pcWKrdHnvckBw\iCqdX3hckBCWkhvN{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUOuOFY6OTVizszN MWHTRW5ITVJ?
SR cell MnXES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NITsbllKdmirYnn0bY9vKG:oIHj1cYFvKFOUIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD12LkS5PVU1KM7:TR?= MX3TRW5ITVJ?
BB65-RCC cell MoOxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWW4O|J5UW6qaXLpeIlwdiCxZjDoeY1idiCEQk[1MXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5yOEKyO{DPxE1? NVvy[VlOW0GQR1XS
BB49-HNC cell NWj0[nZZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWLJcohq[mm2aX;uJI9nKGi3bXHuJGJDPDlvSF7DJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlM5PTl7IN88US=> NFnhRVBUSU6JRWK=
BC-1 cell NX;3Wm5bT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYrJcohq[mm2aX;uJI9nKGi3bXHuJGJENTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTJ6Lk[1NUDPxE1? M2\sPHNCVkeHUh?=
BC-3 cell NIT1VmRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF3mUVlKdmirYnn0bY9vKG:oIHj1cYFvKEKFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGyMlEyOzhizszN MYXTRW5ITVJ?
BL-41 cell MmHhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEjTbGpKdmirYnn0bY9vKG:oIHj1cYFvKEKOLUSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlI6OTJ|IN88US=> M4nLcXNCVkeHUh?=
BL-70 cell NGroNXNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlTWTY5pcWKrdHnvckBw\iCqdX3hckBDVC15MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wNFAxODB6MkG4JO69VQ>? NWHie28zW0GQR1XS
SW684 cell NX7MPFBHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWjJcohq[mm2aX;uJI9nKGi3bXHuJHNYPjh2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkO0PVgh|ryP NUHhZlNwW0GQR1XS
BOKU cell MojTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXnJcohq[mm2aX;uJI9nKGi3bXHuJGJQU1ViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwNEmxN|Mh|ryP NXvu[VluW0GQR1XS
SW954 cell NUTIXWpsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M133emlvcGmkaYTpc44hd2ZiaIXtZY4hW1d7NUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFI6OjdizszN M3vuZ3NCVkeHUh?=
C2BBe1 cell MnXOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVnJcohq[mm2aX;uJI9nKGi3bXHuJGMzSkKnMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wPFMxQCEQvF2= NUG0S2NDW0GQR1XS
BV-173 cell MlmyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mm\OTY5pcWKrdHnvckBw\iCqdX3hckBDXi1zN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFAxODByMUC5JO69VQ>? Mk[xV2FPT0WU
Becker cell Ml3IS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2iyUmlvcGmkaYTpc44hd2ZiaIXtZY4hSmWla3XyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlA{ODB|IN88US=> NG\qPIpUSU6JRWK=
SW982 cell MlvGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXzFWnRLUW6qaXLpeIlwdiCxZjDoeY1idiCVV{m4NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xOTFzNTFOwG0> MnfsV2FPT0WU
697 cell M3fHNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYrVS|BlUW6qaXLpeIlwdiCxZjDoeY1idiB4OUegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNVk6QDdizszN MUXTRW5ITVJ?
TE-15 cell MmXyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmraTY5pcWKrdHnvckBw\iCqdX3hckBVTS1zNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wNFU5QTFizszN NHXDVmdUSU6JRWK=
TE-11 cell NY\tdJhHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnO1TY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wO|g2QCEQvF2= NI[0PYdUSU6JRWK=
TE-5 cell NXjJVYlvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXTJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTFwN{mxN|kh|ryP MVfTRW5ITVJ?
TE-6 cell M4WzTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYPsfXdSUW6qaXLpeIlwdiCxZjDoeY1idiCWRT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2xMlIyOjJ4IN88US=> Ml3sV2FPT0WU
TE-9 cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUDJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwOEe1N|Ih|ryP MnjWV2FPT0WU
TGBC24TKB cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUXJcohq[mm2aX;uJI9nKGi3bXHuJHRISkN{NGTLRkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xPDd4MTFOwG0> M4TGO3NCVkeHUh?=
TGW cell M{D6dmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NED4R2FKdmirYnn0bY9vKG:oIHj1cYFvKFSJVzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MUGuNlgzQCEQvF2= NYLHepZuW0GQR1XS
TK10 cell MmrCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MojHTY5pcWKrdHnvckBw\iCqdX3hckBVUzFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCxNVc1KM7:TR?= MnfIV2FPT0WU
TGBC1TKB cell NYnWOJo5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2O0OWlvcGmkaYTpc44hd2ZiaIXtZY4hXEeEQ{HUT2Ih[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODZzNkSg{txO NXfid5UzW0GQR1XS
A498 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mmf6TY5pcWKrdHnvckBw\iCqdX3hckBCPDl6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkC3Nlg1KM7:TR?= Mnz0V2FPT0WU
UACC-257 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUfJcohq[mm2aX;uJI9nKGi3bXHuJHVCS0NvMkW3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2xNk46OTl6IN88US=> MoHpV2FPT0WU
U-87-MG cell NFrL[4ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYL2c3VkUW6qaXLpeIlwdiCxZjDoeY1idiCXLUi3MW1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0{OC55Nk[g{txO NYKwRYt2W0GQR1XS
BB30-HNC cell Mn\VS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXTsdnl3UW6qaXLpeIlwdiCxZjDoeY1idiCEQkOwMWhPSyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5yNUSzO{DPxE1? M{nueHNCVkeHUh?=
no-10 cell MnjCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYTRemxQUW6qaXLpeIlwdiCxZjDoeY1idiCwbz2xNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4{OTl|MTFOwG0> NEPodoFUSU6JRWK=
CAS-1 cell NU\kNJpwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3uxc2lvcGmkaYTpc44hd2ZiaIXtZY4hS0GVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGuOFA6QTJizszN NVXPbW9bW0GQR1XS
CGTH-W-1 cell M4TTd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWD3fFdrUW6qaXLpeIlwdiCxZjDoeY1idiCFR2TIMXcuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5yM{W0PEDPxE1? NID0ZXBUSU6JRWK=
TE-10 cell NFnGPFdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NG\xU|RKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUGwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlA3OzV5IN88US=> NEjM[pZUSU6JRWK=
COLO-684 cell NGnsdmRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlnwTY5pcWKrdHnvckBw\iCqdX3hckBEV0yRLU[4OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9OFYvOjJ3ODFOwG0> MoPsV2FPT0WU
TE-12 cell MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NE[0ZWNKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlAyQDZzIN88US=> NIDVfGFUSU6JRWK=
COR-L279 cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXmzVIdsUW6qaXLpeIlwdiCxZjDoeY1idiCFT2KtUFI4QSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:PDBwMki1NkDPxE1? M2\idXNCVkeHUh?=
TE-8 cell NV[1bVJKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX7Jcohq[mm2aX;uJI9nKGi3bXHuJHRGNThiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMEG1O|Yh|ryP MoTyV2FPT0WU
CP66-MEL cell NYLWdVdsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml3GTY5pcWKrdHnvckBw\iCqdX3hckBEWDZ4LV3FUEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4yQTV|MTFOwG0> Mlf4V2FPT0WU
CTV-1 cell NIDZSYdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml;ZTY5pcWKrdHnvckBw\iCqdX3hckBEXFZvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wNFAxPDB|NjFOwG0> M2XxSHNCVkeHUh?=
VA-ES-BJ cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NY[5NYRbUW6qaXLpeIlwdiCxZjDoeY1idiCYQT3FV{1DUiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5yM{mwNkDPxE1? MWHTRW5ITVJ?
D-263MG cell NIX0V41Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1Lo[2lvcGmkaYTpc44hd2ZiaIXtZY4hTC1{NkPNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4{PjJ{NDFOwG0> NVnPeHBSW0GQR1XS
D-336MG cell NGPadZZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NG\vd|lKdmirYnn0bY9vKG:oIHj1cYFvKERvM{O2UWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODB4Mkm4JO69VQ>? M3u1bnNCVkeHUh?=
D-502MG cell M4rEUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXK3dpNiUW6qaXLpeIlwdiCxZjDoeY1idiCGLUWwNm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0yNjJ|M{e2JO69VQ>? MUfTRW5ITVJ?
DJM-1 cell MmnHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml7UTY5pcWKrdHnvckBw\iCqdX3hckBFUk1vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;Nj60PFU2QCEQvF2= NX7aVplvW0GQR1XS
no-11 cell NGf5O5RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnPUTY5pcWKrdHnvckBw\iCqdX3hckBvdy1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD61NFIzQCEQvF2= NYD5NJM6W0GQR1XS
DMS-153 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFK5PJdKdmirYnn0bY9vKG:oIHj1cYFvKESPUz2xOVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVE1NjByMkig{txO MVjTRW5ITVJ?
DSH1 cell MlrOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MU\Jcohq[mm2aX;uJI9nKGi3bXHuJGRUUDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMkSwNFEh|ryP NWOyZ5JLW0GQR1XS
DU-4475 cell NFu2VoFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXvJcohq[mm2aX;uJI9nKGi3bXHuJGRWNTR2N{WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUiuNlE3PTJizszN MVvTRW5ITVJ?
EB-3 cell NF7OT41Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NW\kUoNkUW6qaXLpeIlwdiCxZjDoeY1idiCHQj2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2zOE4{OTF6IN88US=> M33zNnNCVkeHUh?=
EHEB cell NIDFRWlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF3UN2NKdmirYnn0bY9vKG:oIHj1cYFvKEWKRVKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGwMlA3PTZizszN NI[4TmdUSU6JRWK=
COLO-829 cell NGjvO5FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUXyXHBIUW6qaXLpeIlwdiCxZjDoeY1idiCFT1zPMVgzQSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5zMkKxN{DPxE1? NEW5dXFUSU6JRWK=
CP67-MEL cell M4i5Xmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYPJcohq[mm2aX;uJI9nKGi3bXHuJGNRPjdvTVXMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlIxPDh6IN88US=> NYm2fnBnW0GQR1XS
ES8 cell MmG3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NELhV|hKdmirYnn0bY9vKG:oIHj1cYFvKEWVODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;M{KuNVI2OiEQvF2= Mn7LV2FPT0WU
EVSA-T cell Mom4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUfVXnczUW6qaXLpeIlwdiCxZjDoeY1idiCHVmPBMXQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVkvOjd5OUOg{txO M4DEXnNCVkeHUh?=
ES4 cell MnXUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4jSW2lvcGmkaYTpc44hd2ZiaIXtZY4hTVN2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1zLkC1NVQ2KM7:TR?= NHLE[FRUSU6JRWK=
ETK-1 cell NF3WTXhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYPFbHh1UW6qaXLpeIlwdiCxZjDoeY1idiCHVFutNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xOjh|MjFOwG0> MknRV2FPT0WU
ES6 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M361WGlvcGmkaYTpc44hd2ZiaIXtZY4hTVN4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCzNVk{KM7:TR?= NHPPV2ZUSU6JRWK=
EW-24 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUHoWolXUW6qaXLpeIlwdiCxZjDoeY1idiCHVz2yOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE44QDF4NTFOwG0> Mn7JV2FPT0WU
EoL-1-cell cell NE\LZ3hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXPJcohq[mm2aX;uJI9nKGi3bXHuJGVwVC1zLXPlcIwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODByMEGzNFkh|ryP MmSzV2FPT0WU
Calu-6 cell NXzE[|FCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXvGR3c5UW6qaXLpeIlwdiCxZjDoeY1idiCFYXz1MVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVMvODV5NEGg{txO M4riVHNCVkeHUh?=
GAK cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIn6W5JKdmirYnn0bY9vKG:oIHj1cYFvKEeDSzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;M{GuNlY5PiEQvF2= NHy2d2NUSU6JRWK=
D-247MG cell Mn7iS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlrxTY5pcWKrdHnvckBw\iCqdX3hckBFNTJ2N13HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME22MlEzPTF7IN88US=> NIPz[o5USU6JRWK=
GB-1 cell M2nTZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEXZN|lKdmirYnn0bY9vKG:oIHj1cYFvKEeELUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFIyPTdizszN NXnMRWw6W0GQR1XS
GI-ME-N cell MlHpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1zVN2lvcGmkaYTpc44hd2ZiaIXtZY4hT0lvTVWtUkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xPjFzODFOwG0> MljMV2FPT0WU
GCIY cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWPJcohq[mm2aX;uJI9nKGi3bXHuJGdEUVliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMEm2OVYh|ryP NHXze5hUSU6JRWK=
GT3TKB cell Mn:3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmjQTY5pcWKrdHnvckBw\iCqdX3hckBIXDOWS1KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUmuN|U2PDZizszN NXOyRpBrW0GQR1XS
HC-1 cell M2LPVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWTIXXpFUW6qaXLpeIlwdiCxZjDoeY1idiCKQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2yOE42PTVzIN88US=> MoO2V2FPT0WU
HAL-01 cell M1LIZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3XYdGlvcGmkaYTpc44hd2ZiaIXtZY4hUEGOLUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2xPU44PTR|IN88US=> MliwV2FPT0WU
HCC1187 cell M3PTemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmXJTY5pcWKrdHnvckBw\iCqdX3hckBJS0NzMUi3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2zOU45ODV{IN88US=> M2LKZXNCVkeHUh?=
DEL cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXXJcohq[mm2aX;uJI9nKGi3bXHuJGRGVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:PDFwOUC4OkDPxE1? NGrpTpBUSU6JRWK=
HCC1599 cell NF[2cFdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MW\Jcohq[mm2aX;uJI9nKGi3bXHuJGhESzF3OUmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUOyMlM{OjVizszN NUPpRllZW0GQR1XS
DOHH-2 cell NFvEWpdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWPJcohq[mm2aX;uJI9nKGi3bXHuJGRQUEhvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wNVcyQSEQvF2= Mlf5V2FPT0WU
HCC2157 cell NInqb|FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mo\CTY5pcWKrdHnvckBw\iCqdX3hckBJS0N{MUW3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2zO{46QTR4IN88US=> NGjDcHVUSU6JRWK=
HCE-4 cell NVr0bYV{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{G0SGlvcGmkaYTpc44hd2ZiaIXtZY4hUEOHLUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNlY1OzlizszN MWjTRW5ITVJ?
HCE-T cell MoXkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVLrW4JmUW6qaXLpeIlwdiCxZjDoeY1idiCKQ1WtWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NU42PjdzNDFOwG0> M2LqfXNCVkeHUh?=
HEL cell NETMWXVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVfWbotnUW6qaXLpeIlwdiCxZjDoeY1idiCKRVygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGwMlQ4PzZizszN NFyw[2ZUSU6JRWK=
EM-2 cell NVLic2ltT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWPJcohq[mm2aX;uJI9nKGi3bXHuJGVONTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMECwNFAyODd6IN88US=> NFjGcVFUSU6JRWK=
HT-144 cell NHXPR2lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn;xTY5pcWKrdHnvckBw\iCqdX3hckBJXC1zNESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuOVM3ODlizszN M{nEeHNCVkeHUh?=
EW-16 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYHy[HYzUW6qaXLpeIlwdiCxZjDoeY1idiCHVz2xOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE44PjF5ODFOwG0> MXXTRW5ITVJ?
IA-LM cell M2jz[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmHOTY5pcWKrdHnvckBw\iCqdX3hckBKSS2OTTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MUKuOFQ1PSEQvF2= M4\4dHNCVkeHUh?=
IST-MEL1 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVPJcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2PRVyxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlE{PDVizszN MYjTRW5ITVJ?
IST-MES1 cell MnH4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M37HZWlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLV3FV|Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODh3NUKg{txO NH:2PFZUSU6JRWK=
GI-1 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NU\kc29YUW6qaXLpeIlwdiCxZjDoeY1idiCJST2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2xMlM3OjJizszN M3LPUnNCVkeHUh?=
IST-SL2 cell NYHweZZCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoLtTY5pcWKrdHnvckBw\iCqdX3hckBKW1RvU1yyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlUxOzB{IN88US=> NWXDOlVwW0GQR1XS
JVM-2 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXHodWh5UW6qaXLpeIlwdiCxZjDoeY1idiCMVl2tNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9Nk4{PjJ6NDFOwG0> MoLyV2FPT0WU
JVM-3 cell M17Oe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVf1T451UW6qaXLpeIlwdiCxZjDoeY1idiCMVl2tN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9N|cvOjN|ODFOwG0> M3zlfHNCVkeHUh?=
KALS-1 cell MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWK2fXliUW6qaXLpeIlwdiCxZjDoeY1idiCNQVzTMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODl2OTFOwG0> NGC0[XBUSU6JRWK=
KARPAS-422 cell M{\E[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH;OS|NKdmirYnn0bY9vKG:oIHj1cYFvKEuDUmDBV{01OjJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwM{O5PVch|ryP MoTUV2FPT0WU
JiyoyeP-2003 cell NHPu[3BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3z6UGlvcGmkaYTpc44hd2ZiaIXtZY4hUmm7b4nlVE0zODB|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1zLkezOFY3KM7:TR?= MorkV2FPT0WU
KARPAS-45 cell MmnhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{\WV2lvcGmkaYTpc44hd2ZiaIXtZY4hU0GUUFHTMVQ2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF04NjVzNkexJO69VQ>? MWPTRW5ITVJ?
KGN cell NVHkeXlsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3fZfGlvcGmkaYTpc44hd2ZiaIXtZY4hU0eQIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCxPVQzKM7:TR?= M3;wOHNCVkeHUh?=
KLE cell MnfWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mk[3TY5pcWKrdHnvckBw\iCqdX3hckBMVEViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMUGzNVch|ryP NWXBTXU4W0GQR1XS
KNS-42 cell M1jDcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmDGTY5pcWKrdHnvckBw\iCqdX3hckBMVlNvNEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUGuNlQ1OTJizszN NFHrVFNUSU6JRWK=
KNS-81-FD cell NIPrZndIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGT2N3VKdmirYnn0bY9vKG:oIHj1cYFvKEuQUz24NU1HTCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OjNwMUS2JO69VQ>? Mn;EV2FPT0WU
KP-N-YS cell NF;0OXFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWjBeFdMUW6qaXLpeIlwdiCxZjDoeY1idiCNUD3OMXlUKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0yOi57MkizJO69VQ>? NYn1fFI4W0GQR1XS
HOP-62 cell MnfBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHj2OmVKdmirYnn0bY9vKG:oIHj1cYFvKEiRUD22NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xOTh|NDFOwG0> NImxPHVUSU6JRWK=
KURAMOCHI cell NFvlWndIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV7Jcohq[mm2aX;uJI9nKGi3bXHuJGtWWkGPT1PITUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xOzR6NzFOwG0> Mmr2V2FPT0WU
HUTU-80 cell M131e2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYjJcohq[mm2aX;uJI9nKGi3bXHuJGhWXFVvOECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuN|E1OiEQvF2= NE\6b3JUSU6JRWK=
LAMA-84 cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NETwWGFKdmirYnn0bY9vKG:oIHj1cYFvKEyDTVGtPFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODByMECzNlA4KM7:TR?= MUjTRW5ITVJ?
LB1047-RCC cell M2rxTGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkXDTY5pcWKrdHnvckBw\iCqdX3hckBNSjFyNEetVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjByOUi4O{DPxE1? Mo\SV2FPT0WU
LB2518-MEL cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NI\TdHFKdmirYnn0bY9vKG:oIHj1cYFvKEyEMkWxPE1OTUxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMUSxOlIh|ryP MVzTRW5ITVJ?
LB373-MEL-D cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX7Jcohq[mm2aX;uJI9nKGi3bXHuJGxDOzd|LV3FUE1FKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjh{NUC4JO69VQ>? M3PsUXNCVkeHUh?=
LB771-HNC cell M3jrdWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFLzTFdKdmirYnn0bY9vKG:oIHj1cYFvKEyEN{exMWhPSyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:Oi53N{W1NUDPxE1? MXHTRW5ITVJ?
LB996-RCC cell NFXP[WxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXnJcohq[mm2aX;uJI9nKGi3bXHuJGxDQTl4LWLDR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xODl7MUKg{txO MlzjV2FPT0WU
LC-2-ad cell Mn;RS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGCzZYZKdmirYnn0bY9vKG:oIHj1cYFvKEyFLUKtZYQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODJ3OE[g{txO NFnMPVhUSU6JRWK=
J-RT3-T3-5 cell M1zsWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnXuTY5pcWKrdHnvckBw\iCqdX3hckBLNVKWMz3UN{02KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF05Njl4NUK5JO69VQ>? MYDTRW5ITVJ?
LP-1 cell M1y2emdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFPFSoVKdmirYnn0bY9vKG:oIHj1cYFvKEySLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUeuOVQ4QDJizszN Mlm2V2FPT0WU
K-562 cell NUDt[21JT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoXzTY5pcWKrdHnvckBw\iCqdX3hckBMNTV4MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wNFAxODB{NkW2JO69VQ>? NIrXcGtUSU6JRWK=
LS-123 cell Mn3uS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MorPTY5pcWKrdHnvckBw\iCqdX3hckBNWy1zMkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNVQxPjRizszN MofRV2FPT0WU
K5 cell MlmyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MojUTY5pcWKrdHnvckBw\iCqdX3hckBMPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LlnDOVA:OC5zNkS4PUDPxE1? M4r6N3NCVkeHUh?=
LS-411N cell NWi2U|F6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4LEVmlvcGmkaYTpc44hd2ZiaIXtZY4hVFNvNEGxUkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9OFgvPDd2ODFOwG0> MX;TRW5ITVJ?
KG-1 cell MlW1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWLIT5UxUW6qaXLpeIlwdiCxZjDoeY1idiCNRz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME20MlYxQDR3IN88US=> M1O5RXNCVkeHUh?=
KINGS-1 cell M3X1XWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXXJcohq[mm2aX;uJI9nKGi3bXHuJGtKVkeVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNVY3PjZizszN NGS0dGxUSU6JRWK=
LXF-289 cell MkLtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF31fJBKdmirYnn0bY9vKG:oIHj1cYFvKEy[Rj2yPFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvODN7NU[g{txO MnGxV2FPT0WU
MC116 cell MoixS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MorQTY5pcWKrdHnvckBw\iCqdX3hckBOSzFzNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xNVQyKM7:TR?= NFH4XolUSU6JRWK=
KS-1 cell M2jsZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmT0TY5pcWKrdHnvckBw\iCqdX3hckBMWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1yLkCyO|Mh|ryP NUf4NpVlW0GQR1XS
KU812 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnruTY5pcWKrdHnvckBw\iCqdX3hckBMXThzMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6xNVg5OyEQvF2= NXj3Wlg5W0GQR1XS
MEG-01 cell NWKwUFNCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{i3PGlvcGmkaYTpc44hd2ZiaIXtZY4hVUWJLUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlAxODByOUiwOUDPxE1? MUXTRW5ITVJ?
MFH-ino cell NYjCe25kT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3vUVGlvcGmkaYTpc44hd2ZiaIXtZY4hVU[KLXnuc{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xPDd{NDFOwG0> MmDVV2FPT0WU
L-540 cell MkfpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoO1TY5pcWKrdHnvckBw\iCqdX3hckBNNTV2MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MUWuNFY4OSEQvF2= M3W2e3NCVkeHUh?=
MHH-NB-11 cell NWWxTGRPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXnJcohq[mm2aX;uJI9nKGi3bXHuJG1JUC2QQj2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9OFMvODhzODFOwG0> M1TRUnNCVkeHUh?=
MMAC-SF cell MnjqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4C5[WlvcGmkaYTpc44hd2ZiaIXtZY4hVU2DQz3TSkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9PE44QTNyNzFOwG0> NUDFZ3Y5W0GQR1XS
LB2241-RCC cell M4PBS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NI\RXYlKdmirYnn0bY9vKG:oIHj1cYFvKEyEMkK0NU1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTlwMEKwNVIh|ryP M3PhRnNCVkeHUh?=
LB831-BLC cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVzJcohq[mm2aX;uJI9nKGi3bXHuJGxDQDNzLVLMR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9NE4xPDZyOTFOwG0> NIX2cXNUSU6JRWK=
MOLT-16 cell NVf3TldJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFfQXI1KdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVI6NjZ{OUKg{txO MkPzV2FPT0WU
LC-1F cell MoL4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWPJcohq[mm2aX;uJI9nKGi3bXHuJGxENTGIIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1{Nz6zNlQ2KM7:TR?= M3;EfXNCVkeHUh?=
MOLT-4 cell Mn\QS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4jmVGlvcGmkaYTpc44hd2ZiaIXtZY4hVU:OVD20JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2yOk43PzV|IN88US=> NGjZPY1USU6JRWK=
MZ1-PC cell M3XJbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVzJcohq[mm2aX;uJI9nKGi3bXHuJG1bOS2SQzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MD6wN|EyQSEQvF2= MnLTV2FPT0WU
MONO-MAC-6 cell NH;uXFRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHKxfpBKdmirYnn0bY9vKG:oIHj1cYFvKE2RTl:tUWFENTZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRThwMkewOlYh|ryP M{njcHNCVkeHUh?=
MZ2-MEL cell Mom5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml:5TY5pcWKrdHnvckBw\iCqdX3hckBOYjJvTVXMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlI5PTN5IN88US=> NUfvfFVlW0GQR1XS
MPP-89 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mm[0TY5pcWKrdHnvckBw\iCqdX3hckBOWFBvOEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuNFQxPDlizszN NVnqeFNYW0GQR1XS
MZ7-mel cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHjhV4JKdmirYnn0bY9vKG:oIHj1cYFvKE2cNz3t[Ywh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVAvPDd7MUGg{txO NGjafmtUSU6JRWK=
LOXIMVI cell M3LRZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVLJcohq[mm2aX;uJI9nKGi3bXHuJGxQYEmPVlmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUCuN|E2ODNizszN M2LEN3NCVkeHUh?=
NALM-6 cell MknhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M131eWlvcGmkaYTpc44hd2ZiaIXtZY4hVkGOTT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlE6Ojl3IN88US=> NHrE[FRUSU6JRWK=
NB13 cell NUXRT4RiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkjvTY5pcWKrdHnvckBw\iCqdX3hckBPSjF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmuTWM2OD1zOT60PFc4KM7:TR?= MWfTRW5ITVJ?
NB5 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEHlOWxKdmirYnn0bY9vKG:oIHj1cYFvKE6ENTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MT6zPVgzPyEQvF2= MYHTRW5ITVJ?
NB17 cell M1jkPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYTJcohq[mm2aX;uJI9nKGi3bXHuJG5DOTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTNwNkO4OFch|ryP MULTRW5ITVJ?
NCCIT cell NEHROXpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXW2cJFWUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1PJWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NkmFNUC9Nk45PjZzNjFOwG0> M4\BdHNCVkeHUh?=
NB69 cell NVP5N281T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVrJcohq[mm2aX;uJI9nKGi3bXHuJG5DPjliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMUS0N|Yh|ryP M33pNHNCVkeHUh?=
NCI-H1304 cell NXv3e3EyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmW0TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEGzNFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS6LQ{WwQVI5NjF4Mkig{txO M1rrWnNCVkeHUh?=
NCI-H1395 cell M1XjRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1fIVWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixN|k2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF01Oi5yMU[zJO69VQ>? MVLTRW5ITVJ?
MHH-PREB-1 cell MlXuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmDrTY5pcWKrdHnvckBw\iCqdX3hckBOUEhvUGLFRk0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwSVO1NF0xNjd2NE[5JO69VQ>? NXP0emdTW0GQR1XS
MLMA cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWDvRYpJUW6qaXLpeIlwdiCxZjDoeY1idiCPTF3BJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvUUN3ME2wMlE1ODN{IN88US=> M3vMNXNCVkeHUh?=
MN-60 cell NUGxXpRZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmHRTY5pcWKrdHnvckBw\iCqdX3hckBOVi14MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MmlEPTB;MUWuNVk4QSEQvF2= NEHJe45USU6JRWK=
MV-4-11 cell M{DpV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWDJcohq[mm2aX;uJI9nKGi3bXHuJG1XNTRvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUSuN|Y1PTRizszN NXy3WYh{W0GQR1XS
NB6 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXzYN|FJUW6qaXLpeIlwdiCxZjDoeY1idiCQQk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU5KSzVyPUmuPVIzPTlizszN MXjTRW5ITVJ?
NCI-H1355 cell NF\We|JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVfIcWU3UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE{PTViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeT7JR|UxRTBwMUGwNlgh|ryP M2S0[HNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
phospho-c-Abl(Tyr245) / phospho-c-Src(Tyr416) ; 

PubMed: 23049975     


Protein levels of phosphorylated c-Abl (Tyr245), c-Abl, phosphorylated c-Src (Tyr416), c-Src, and GAPDH in NSC-34 cells overexpressing human wild-type or mutant SOD1s treated with various concentrations of dasatinib were measured by western blot. Cells were cultured in serum-free culture medium with doxycycline (Dox, 2 µg/ml), and western blot was performed at 24 h after dasatinib addition.

p27 / p21; 

PubMed: 20145167     


Dasatnib induced cell cycle arrest. Dasatinib induced growth arrest, shown as a cell cycle distribution graph in the lower panel, correlated with increased p27 and p21 levels. Western blotting for levels of p27 and p21 was performed on protein lysates of THP-1 cells treated for 48 hours with indicated doses of dasatinib or DMSO. Detection of actin served as control for comparable protein loading.

cleaved caspase 3 ; 

PubMed: 20145167     


Dasatinib induced apoptosis. Dasatinib causes apoptosis in Mo7e-KitD816H cells as detected by cleavage of caspase 3. Whole cell lysates were prepared after 24 hour treatment with dasatinib. Caspase 3 and cleaved capase 3 were analyzed by western blotting. Actin serves as loading control.

p-FAK/p-STAT3; 

PubMed: 23721490     


The effect of dasatinib in cell signalling. Western blot analysis with phosphorylated Src, FAK, Stat3, Akt and MAPK in HCC cell lines after 24 hours treatment of dasatinib. The cell lines were arranged according to their IC50 to dasatinib. The top three were most sensitive, the bottom 3 were least sensitive.

23049975 20145167 23721490
Growth inhibition assay
Cell viability; 

PubMed: 23721490     


9 HCC cell lines were exposed to the dedicated concentrations of dasatinib for 72 hours, and IC50 was tested by MTS. Results represent the mean (± SD) of three experiments.

23721490
Immunofluorescence
SRC / Met; 

PubMed: 26517812     


Immunocytochemistry of SRC and Met localization. Cellular localization of SRC and Met following treatment for 48 h with dasatinib, crizotinib or combination in A. LN-18 and B. U373 cells. Scale bar denotes 10 μm. Nuclei were visualized by DAPI while SRC and Met were labeled with a fluorescein and Texas-red conjugated secondary antibodies, respectively.

α-tubulin; 

PubMed: 26517812     


Combination of dasatinib and crizotinib impedes the formation of the α-tubulin-labeled mitotic spindle. LN-18 cells were treated with dasatinib 0.2 μM, crizotinib 4 μM or their combination for 48 h. Mitotic spindle were visualized using α-tubulin antibody conjugated to a fluorescein-labeled secondary antibody. Nuclei were stained by DAPI. The scale bar denotes 10 μm.

F-actin / Actinin-4 / Paxillin; 

PubMed: 31053734     


Conditionally immortalized differentiated podocytes treated for one-hour with 2 µM kinase inhibitor were stained for F-actin (phalloidin), α-actinin-4, paxillin, and nuclei (Hoechst 33342) to assess cytoskeletal and focal adhesion architecture (scale bars = 50 µm). Podocytes treated with dasatinib showed a marked decrease in cell-to-cell contacts, cell size and number of focal adhesions.

26517812 31053734
ELISA
TNF-α; 

PubMed: 17684099     


U937 cells were differentiated with vitamin D3, pretreated with the indicated concentrations of drugs for 1 h and stimulated with LPS for 6 h. TNF-α secretion was measured by ELISA. The graph shows the mean of two experiments done in duplicate.

E-selectin; 

PubMed: 31110200     


HAoECs were treated with DMSO, a dual FAK/Pyk2 inhibitor (PF-271, 2.5 μM), a Src inhibitor (Dasatinib, 1 μM), or a FAK inhibitor (PF-228, 10 μM) for 1 h prior to TNF-α (10 ng/ml, 6 h) stimulation. Expression levels of E-selectin was determined using ELISA (n = 3, ±SEM).

VCAM-1; 

PubMed: 31110200     


HAoECs were treated with DMSO, a dual FAK/Pyk2 inhibitor (PF-271, 2.5 μM), a Src inhibitor (Dasatinib, 1 μM), or a FAK inhibitor (PF-228, 10 μM) for 1 h prior to TNF-α (10 ng/ml, 6 h) stimulation. Expression levels of VCAM-1 was determined using ELISA (n = 3, ±SEM).

17684099 31110200
体内研究 Dasatinib逆转LMP2A/MYC双重转基因小鼠体内的脾肿大。在TgE 小鼠体内,Dasatinib特异性防止LMP2A表达的骨髓B细胞形成集落,并减少脾脏大小。与对照组相比,Dasatinib治疗的Tg6/λ-MYC小鼠中,脾脏肿块显著减小。Dasatinib抑制LMP2A/MYC双重转基因小鼠体内的淋巴结肿大。从LMP2A/MYC双重转基因小鼠移植肿瘤细胞的Rag1KO小鼠体内,Dasatinib逆转脾肿大。Dasatinib治疗抑制表达LMP2A的B淋巴肿瘤细胞中Lyn磷酸化。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

激酶自磷酸化测定:

激酶试验使用野生型和突变型谷胱甘肽S转移酶(GST)-Abl融合蛋白(c-Abl 氨基酸220-498)进行。GST-Abl在使用前从谷胱甘肽-琼脂糖珠中释放;ATP浓度为5 μM。在用于激酶磷酸化和体外多肽底物磷酸化试验之前,GST-Abl激酶域融合蛋白立即用LAR酪氨酸磷酸酶处理。在30℃下培养1小时后,LAR磷酸酶通过加入钒酸钠(1 mM)灭活。比较未处理的GST-Abl激酶和去磷酸化的GST-Abl激酶,免疫印记分析按照常规进行,使用磷酸酪氨酸特异性抗体4G10以确定酪氨酸残基完全去磷酸化(>95%),使用c-Abl抗体CST 2862确定GST-Abl激酶等量加入。对于突变型T315I,Dasatinib浓度范围扩展到1,000 nM。这些同样的抑制剂浓度用于体外多肽底物磷酸化试验。测试三个抑制剂在相同浓度范围内对GST-Src 激酶和GST-Lyn激酶的抑制作用。
细胞实验:

[1]

- 合并
  • Cell lines: Ba/F3 细胞系
  • Concentrations: ~32 nM
  • Incubation Time: 72小时
  • Method: Ba/F3细胞系以一式三份接种,并与逐渐增加浓度的Dasatinib培养72小时。使用基于甲烷硫代磺酸盐的活性试验测量增殖。IC50和IC90值以重复四次的三个独立实验平均值确定。抑制剂浓度范围为0 nM到32 nM (Dasatinib)。对于突变型T315I,Dasatinib浓度范围扩展到200 nM。
    (Only for Reference)
动物实验:

[3]

- 合并
  • Animal Models: EμLMP2A (TgE和Tg6菌株),MYC (λ-MYC),和LMP2A/λ-MYC 双重转基因小鼠(Tg6/λ-MYC)
  • Dosages: 30 mg/kg
  • Administration: 腹腔注射给药
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 21 mg/mL warmed (41.5 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+dd H2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 506.02
化学式

C22H28ClN7O3S

CAS号 863127-77-9
储存条件 粉状
溶于溶剂
别名 BMS-354825 Monohydrate

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04933526 Not yet recruiting Drug: Flumatinib|Drug: Dasatinib Chronic Myeloid Leukemia in Chronic Phase Shenzhen Second People''s Hospital July 1 2021 Phase 4
NCT04925648 Not yet recruiting Drug: Dasatinib|Drug: Darolutamide Metastatic Prostate Cancer St Vincent''s Hospital Sydney July 1 2021 Phase 2
NCT04063124 Recruiting Drug: Dasatinib + Quercetin Alzheimer Disease The University of Texas Health Science Center at San Antonio|Mayo Clinic February 14 2020 Phase 1|Phase 2
NCT04155411 Recruiting Drug: Dasatinib Dasatinib|BCR-ABL|Chronic Myeloid Leukemia Shenzhen Second People''s Hospital December 1 2019 Phase 4

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    What’s the difference between S1021 and S7782?

  • 回答:

    Usually, hydrate will be more stable and dissolve better than free base. But this compound (S1021) dissolves better in DMSO than hydrate one (S7782).

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID