Vinorelbine ditartrate (KW-2307)

目录号:S4269 别名: Nor-5'-anhydrovinblastine ditartrate 中文名称:酒石酸长春瑞滨

仅限科研使用

Vinorelbine Tartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate)是半合成的长春花生物碱,通过与tubulin相互作用抑制有丝分裂。Vinorelbine Tartrate 可通过诱导有丝分裂的凋亡、自噬和炎症来显示抗肿瘤的活性。

Vinorelbine ditartrate (KW-2307) Chemical Structure

CAS: 125317-39-7

规格 价格 库存 购买数量
RMB 957.75 现货
RMB 3234.77 现货
大包装 有超大折扣

今日订购,明日送达 全国免运费 分装免费 分装成小规格产品(单支最小为1mg)
如1支10mg产品可分装为10支1mg产品

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Vinorelbine ditartrate (KW-2307)发表文献25篇:

产品安全说明书

Microtubule Associated抑制剂选择性比较

相关Microtubule Associated产品

生物活性

产品描述 Vinorelbine Tartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate)是半合成的长春花生物碱,通过与tubulin相互作用抑制有丝分裂。Vinorelbine Tartrate 可通过诱导有丝分裂的凋亡、自噬和炎症来显示抗肿瘤的活性。
特性 A semi-synthetic vinca alkaloid as an anti-mitotic chemotherapy drug.
靶点
Tubulin [1]
(Cell-free assay)
体外研究

Vinorelbine通过诱导微管蛋白聚合成螺旋和类晶体抑制微管组装。[1] Vinorelbine表现出对一系列肿瘤细胞,包括人类黑色素瘤,非小细胞肺癌,乳腺癌等强有力的抗恶性肿瘤增生活性。[2][3][4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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Assay
Methods Test Index PMID
Western blot Cyclin A / Cyclin B1 / p-Histone H3 / CDK1 / PCNA 19017359
Immunofluorescence RPS6 / G3BP1 / TIAR G3BP1 / eIF3b / eIF4G 27083003
Growth inhibition assay Cell number 19017359
体内研究 在体内,Vinorelbine也表现出对一系列皮下植入的人类肿瘤异种移植的抗肿瘤活性。[5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

动物实验:[5]
  • Animal Models: 膀胱(BXF1299),胰腺(PAXF546),肾脏(RXF944LX),结肠癌(DLD-1,HT-29,TC37),中枢神经系统(SF-295),小细胞肺癌(NCI-H69)和前列腺(PC-3)异种移植物。
  • Dosages: ~10 毫克/千克
  • Administration: i.p.

溶解度(25°C)

体外

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 1079.11
化学式

C45H54N4O8.2C4H6O6

CAS号 125317-39-7
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04896320 Recruiting Drug: Tucatinib Breast Cancer Stage IV Providence Health & Services|Seagen Inc. December 15 2021 Phase 1|Phase 2
NCT04299113 Recruiting Drug: Vinorelbine|Drug: Mocetinostat Rhabdomyosarcoma Jonsson Comprehensive Cancer Center|Mirati Therapeutics Inc.|Phase One Foundation May 14 2020 Phase 1
NCT03891173 Terminated Drug: L-DOS47|Drug: Cisplatin|Drug: Vinorelbine Lung Adenocarcinoma Helix BioPharma Corporation|KCR S.A. February 19 2019 Phase 2
NCT02925000 Completed Drug: TLC178 Cancer Taiwan Liposome Company June 19 2017 Phase 1|Phase 2
NCT02658084 Terminated Drug: Vinorelbine|Drug: Trastuzumab Emtansine Breast Cancer|Metastatic Breast Cancer University of Miami|Genentech Inc. April 12 2017 Phase 1|Phase 2
NCT02768415 Unknown status Drug: Apatinib|Drug: Oral Vinorelbine Breast Cancer Chinese Academy of Medical Sciences June 2016 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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