PPAR

信号通路图

研究领域

抑制剂选择性比较

特异性亚型抑制剂

PPAR产品

目录号 产品描述 文献引用 实验数据
S2871

T0070907

T0070907是一种有效的,选择性PPARγ抑制剂,无细胞试验中IC50为1 nM,比作用于PPARα和PPARδ选择性高800倍以上。

S2798New

GW6471

GW6471是一种PPARα的抑制剂,它的IC50是0.24 μM 。

S7767

AZ6102

AZ6102是有效的TNKS1/2抑制剂,选择性比作用于其他PARP家族的激酶高100倍,其在DLD-1细胞中抑制Wnt信号通路(IC50为5 nM)。

S7484

FH535

FH535是一种Wnt/β-catenin信号传导抑制剂,同时也是PPARγPPARδ的双重拮抗剂。

S5824

Cinnamyl alcohol

Cinnamyl alcohol是一种存在于肉桂中的天然产物。

S5113

Propyl gallate

Propyl gallate is an antioxidant used in foods especially animal fats and vegetable oils, also in a wide variety of cosmetics and beauty care products.

S4527

Fenofibric acid

Fenofibric acid是一种降脂剂,降低低密度脂蛋白胆固醇和甘油三脂。

S8029

WY-14643 (Pirinixic Acid)

WY-14643 (Pirinixic Acid)是一种有效的过氧化物酶体增殖子和PPARα激活剂,EC50为1.5 μM。

S1729

Gemfibrozil

Gemfibrozil 是一种降低血脂水平的化合物。

S1849

Daidzein

Daidzein属于异黄酮类。

S9189

Oroxin A

Oroxin A, an active component isolated from the herb Oroxylum indicum (L.) Kurz, activates PPARγ and inhibits α-glucosidase, exerting antioxidant activity.

S5121

Phytol

Phytol, a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.

S3875

Alpinetin

Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities.

S5851

4'-Methoxychalcone

4'-Methoxychalcone存在于柑橘属植物中,是一种查耳酮衍生物,具有多种药理活性,如抗肿瘤和消炎活性。

S4708

Palmitoylethanolamide

Palmitoylethanolamide(PEA)是一种内源性的脂肪酸酰胺,能在体外选择性激活PPAR-α,EC50为3.1±0.4 μM。

S9177

Gypenoside XLIX

Gypenoside XLIX, a naturally occurring gynosaponin, is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator.

S2915

GW9662

GW9662是一种选择性PPAR拮抗剂,作用于PPARγ,无细胞试验中IC50为3.3 nM,在细胞中作用于PPARγ比作用于PPARα和PPARδ的功能选择性强10到600倍。

S8025

GSK3787

GSK3787是一种选择性的,不可逆PPARδ拮抗剂,pIC50为6.6,对hPPARα和hPPARγ没有亲和力。

S5817

GSK0660

GSK0660是有效的PPARβ/δ拮抗剂,pIC50为6.8。在浓度高达近于10 μM时,对PPARα和PPARγ没有活性。

S2505

Rosiglitazone maleate

Rosiglitazone maleate 是一种噻唑烷二酮类抗高血糖药,是PPARγ的高亲和、选择性的激动剂,IC50为42 nM。Rosiglitazone maleate 也能调节 TRP channels并诱导自噬。Rosiglitazone 可预防铁死亡。

S2556

Rosiglitazone

Rosiglitazone 是有效的降糖药,也是有效的噻唑烷二酮类胰岛素增敏剂,在大鼠,3T3-L1和人体脂肪细胞中IC50分别为12,4和9 nM。Rosiglitazone是PPAR-gamma的配体,对PPAR-alpha没有结合力。Rosiglitazone 可调控 TRP channels 并诱导自噬。Rosiglitazone可阻止铁死亡。

S2590

Pioglitazone

Pioglitazone 是一种选择性过氧化物酶体增殖物激活受体γ (PPARγ) 激动剂, 用于治疗糖尿病。是全长hPPARα的弱激活剂,对全长hPPARδ没有作用。

S8020

GW0742

GW0742是一种有效的,选择性PPARβ/δ激动剂,IC50为1 nM,比作用于hPPARα和hPPARγ选择性高1000倍。

S2665

Ciprofibrate

Ciprofibrate是一种过氧化物酶体增殖物激活受体激动剂。

S4159

Bezafibrate

Bezafibrate 是第一个临床测试的双重pan-peroxisome proliferator-activated receptors (PPAR)(过氧化物酶体增殖物激活受体)联合激动剂。

S4207

Clofibric Acid

Clofibric acid 是PPARα激动剂,是一种降血脂剂。

S1794

Fenofibrate

Fenofibrate 是一种Fibrate类化合物,是纤维酸衍生物。

S2075

Rosiglitazone HCl

Rosiglitazone HCl是一种降血糖药物,通过在脂肪细胞中与PPAR受体结合而刺激胰岛素分泌。

S9199

Pseudoginsenoside F11

Pseudoginsenoside F11, a natural product found in American ginseng but not in Asian ginseng, is a novel partial PPARγ agonist.

S8770

Lanifibranor(IVA-337)

Lanifibranor (IVA-337)是一种泛PPAR激动剂,对hPPARα、hPPARδ 和 hPPARγ的EC50值分别为1537 nM、866 nM和206 nM。

S3846

Eupatilin

Eupatilin, a major flavonoid from Artemisia plants, possesses various beneficial biological effects including anti-inflammation, anti-tumor, anti-cancer, anti-allergy, and anti-oxidation activity.

S3786

Glabridin

Glabridin, one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.

S8432

Troglitazone (CS-045)

Troglitazone是PPAR的有效激动剂,PPAR是配体激活的转录因,可参与调解细胞分化和生长。

S3878

Bavachinin

Bavachinina ia a novel natural pan-PPAR agonist from the fruit of the traditional Chinese glucose-lowering herb malaytea scurfpea. It shows stronger activities with PPAR-γ than with PPAR-α and PPAR-β/δ (EC50 = 0.74 μmol/l, 4.00 μmol/l and 8.07 μmol/l in 293T cells, respectively).

S5812

Choline Fenofibrate

Choline fenofibrate是一种非诺贝特酸的胆碱盐,非诺贝特酸是一种合成的苯氧异丁酸衍生物,具有抗高血脂活性,是PPARα激动剂。

S3720

Elafibranor

Elafibranor是PPAR-alphaPPAR-δ的激动剂,改善胰岛素敏感度、有益于葡萄糖稳态、脂质代谢并减少炎症。

S9480

Raspberry Ketone

Raspberry ketone是一种天然存在的酚类化合物,是红莓中的主要芳香化合物。

S5615

Cardarine (GW501516)

GW501516 is a synthetic PPARδ-specific agonist that displays high affinity for PPARδ (Ki=1.1 nM) with > 1000 fold selectivity over PPARα and PPARγ.

S3834

Astaxanthin

Astaxanthin, a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability.

S3868

Harmine

Harmine is an alkaloid of the β-carboline family that regulates PPARγ expression through inhibition of the Wnt signaling pathway. It also selectively binds to MAO-A and reversibly inhibits monoamine oxidase A (MAO-A) but not the variant MAO-B.

目录号 产品描述 文献引用 实验数据
S2871

T0070907

T0070907是一种有效的,选择性PPARγ抑制剂,无细胞试验中IC50为1 nM,比作用于PPARα和PPARδ选择性高800倍以上。

S2798New

GW6471

GW6471是一种PPARα的抑制剂,它的IC50是0.24 μM 。

S7767

AZ6102

AZ6102是有效的TNKS1/2抑制剂,选择性比作用于其他PARP家族的激酶高100倍,其在DLD-1细胞中抑制Wnt信号通路(IC50为5 nM)。

S7484

FH535

FH535是一种Wnt/β-catenin信号传导抑制剂,同时也是PPARγPPARδ的双重拮抗剂。

S5824

Cinnamyl alcohol

Cinnamyl alcohol是一种存在于肉桂中的天然产物。

S5113

Propyl gallate

Propyl gallate is an antioxidant used in foods especially animal fats and vegetable oils, also in a wide variety of cosmetics and beauty care products.

S4527

Fenofibric acid

Fenofibric acid是一种降脂剂,降低低密度脂蛋白胆固醇和甘油三脂。

目录号 产品描述 文献引用 实验数据
S8029

WY-14643 (Pirinixic Acid)

WY-14643 (Pirinixic Acid)是一种有效的过氧化物酶体增殖子和PPARα激活剂,EC50为1.5 μM。

S1729

Gemfibrozil

Gemfibrozil 是一种降低血脂水平的化合物。

S1849

Daidzein

Daidzein属于异黄酮类。

S9189

Oroxin A

Oroxin A, an active component isolated from the herb Oroxylum indicum (L.) Kurz, activates PPARγ and inhibits α-glucosidase, exerting antioxidant activity.

S5121

Phytol

Phytol, a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.

S3875

Alpinetin

Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities.

S5851

4'-Methoxychalcone

4'-Methoxychalcone存在于柑橘属植物中,是一种查耳酮衍生物,具有多种药理活性,如抗肿瘤和消炎活性。

S4708

Palmitoylethanolamide

Palmitoylethanolamide(PEA)是一种内源性的脂肪酸酰胺,能在体外选择性激活PPAR-α,EC50为3.1±0.4 μM。

S9177

Gypenoside XLIX

Gypenoside XLIX, a naturally occurring gynosaponin, is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator.

目录号 产品描述 文献引用 实验数据
S2915

GW9662

GW9662是一种选择性PPAR拮抗剂,作用于PPARγ,无细胞试验中IC50为3.3 nM,在细胞中作用于PPARγ比作用于PPARα和PPARδ的功能选择性强10到600倍。

S8025

GSK3787

GSK3787是一种选择性的,不可逆PPARδ拮抗剂,pIC50为6.6,对hPPARα和hPPARγ没有亲和力。

S5817

GSK0660

GSK0660是有效的PPARβ/δ拮抗剂,pIC50为6.8。在浓度高达近于10 μM时,对PPARα和PPARγ没有活性。

目录号 产品描述 文献引用 实验数据
S2505

Rosiglitazone maleate

Rosiglitazone maleate 是一种噻唑烷二酮类抗高血糖药,是PPARγ的高亲和、选择性的激动剂,IC50为42 nM。Rosiglitazone maleate 也能调节 TRP channels并诱导自噬。Rosiglitazone 可预防铁死亡。

S2556

Rosiglitazone

Rosiglitazone 是有效的降糖药,也是有效的噻唑烷二酮类胰岛素增敏剂,在大鼠,3T3-L1和人体脂肪细胞中IC50分别为12,4和9 nM。Rosiglitazone是PPAR-gamma的配体,对PPAR-alpha没有结合力。Rosiglitazone 可调控 TRP channels 并诱导自噬。Rosiglitazone可阻止铁死亡。

S2590

Pioglitazone

Pioglitazone 是一种选择性过氧化物酶体增殖物激活受体γ (PPARγ) 激动剂, 用于治疗糖尿病。是全长hPPARα的弱激活剂,对全长hPPARδ没有作用。

S8020

GW0742

GW0742是一种有效的,选择性PPARβ/δ激动剂,IC50为1 nM,比作用于hPPARα和hPPARγ选择性高1000倍。

S2665

Ciprofibrate

Ciprofibrate是一种过氧化物酶体增殖物激活受体激动剂。

S4159

Bezafibrate

Bezafibrate 是第一个临床测试的双重pan-peroxisome proliferator-activated receptors (PPAR)(过氧化物酶体增殖物激活受体)联合激动剂。

S4207

Clofibric Acid

Clofibric acid 是PPARα激动剂,是一种降血脂剂。

S1794

Fenofibrate

Fenofibrate 是一种Fibrate类化合物,是纤维酸衍生物。

S2075

Rosiglitazone HCl

Rosiglitazone HCl是一种降血糖药物,通过在脂肪细胞中与PPAR受体结合而刺激胰岛素分泌。

S9199

Pseudoginsenoside F11

Pseudoginsenoside F11, a natural product found in American ginseng but not in Asian ginseng, is a novel partial PPARγ agonist.

S8770

Lanifibranor(IVA-337)

Lanifibranor (IVA-337)是一种泛PPAR激动剂,对hPPARα、hPPARδ 和 hPPARγ的EC50值分别为1537 nM、866 nM和206 nM。

S3846

Eupatilin

Eupatilin, a major flavonoid from Artemisia plants, possesses various beneficial biological effects including anti-inflammation, anti-tumor, anti-cancer, anti-allergy, and anti-oxidation activity.

S3786

Glabridin

Glabridin, one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.

S8432

Troglitazone (CS-045)

Troglitazone是PPAR的有效激动剂,PPAR是配体激活的转录因,可参与调解细胞分化和生长。

S3878

Bavachinin

Bavachinina ia a novel natural pan-PPAR agonist from the fruit of the traditional Chinese glucose-lowering herb malaytea scurfpea. It shows stronger activities with PPAR-γ than with PPAR-α and PPAR-β/δ (EC50 = 0.74 μmol/l, 4.00 μmol/l and 8.07 μmol/l in 293T cells, respectively).

S5812

Choline Fenofibrate

Choline fenofibrate是一种非诺贝特酸的胆碱盐,非诺贝特酸是一种合成的苯氧异丁酸衍生物,具有抗高血脂活性,是PPARα激动剂。

S3720

Elafibranor

Elafibranor是PPAR-alphaPPAR-δ的激动剂,改善胰岛素敏感度、有益于葡萄糖稳态、脂质代谢并减少炎症。

S9480

Raspberry Ketone

Raspberry ketone是一种天然存在的酚类化合物,是红莓中的主要芳香化合物。

S5615

Cardarine (GW501516)

GW501516 is a synthetic PPARδ-specific agonist that displays high affinity for PPARδ (Ki=1.1 nM) with > 1000 fold selectivity over PPARα and PPARγ.

目录号 产品描述 文献引用 实验数据
S3834

Astaxanthin

Astaxanthin, a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability.

S3868

Harmine

Harmine is an alkaloid of the β-carboline family that regulates PPARγ expression through inhibition of the Wnt signaling pathway. It also selectively binds to MAO-A and reversibly inhibits monoamine oxidase A (MAO-A) but not the variant MAO-B.