BMS-754807

For research use only. Not for use in humans.

目录号:S1124

BMS-754807 Chemical Structure

CAS No. 1001350-96-4

BMS-754807是一种有效的IGF-1R/InsR可逆性抑制剂,在无细胞试验中IC50为1.8 nM/1.7 nM,对Met (c-Met),Aurora A/B,TrkA/B和Ron作用稍弱,对Flt3, Lck,MK2,PKA,PKC等几乎没有抑制活性。Phase 2。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 2211.3 现货
RMB 1480.09 现货
RMB 2214.12 现货
RMB 6299.66 现货
RMB 16953.3 现货
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客户使用Selleck生产的BMS-754807发表文献40篇:

产品安全说明书

IGF-1R抑制剂选择性比较

生物活性

产品描述 BMS-754807是一种有效的IGF-1R/InsR可逆性抑制剂,在无细胞试验中IC50为1.8 nM/1.7 nM,对Met (c-Met),Aurora A/B,TrkA/B和Ron作用稍弱,对Flt3, Lck,MK2,PKA,PKC等几乎没有抑制活性。Phase 2。
特性 胰岛素样生长因子-1R/IR家族激酶的多重抑制剂
靶点
Insulin Receptor [1]
(Cell-free assay)
IGF-1R [1]
(Cell-free assay)
TrkB [1]
(Cell-free assay)
Met [1]
(Cell-free assay)
TrkA [1]
(Cell-free assay)
1.7 nM 1.8 nM 4.1 nM 5.6 nM 7.4 nM
体外研究

BMS-754807 有效抑制人类多种不同组织来源的肿瘤细胞系的生长,包括间充质(尤文氏肉瘤,横纹肌肉瘤,神经母细胞瘤,和脂肪肉瘤),上皮(乳腺,肺,胰腺,结肠,和胃),和造血(多发性骨髓瘤和白血病)组织,IC50值从5 nM 到 365 nM。BMS-754807 抑制 IGF-1R-Sal 细胞和 RH41细胞增殖,IC50分别为7 nM 和5 nM。BMS-754807作用于IGF-1R-Sal, Rh41 和 Geo细胞,抑制IGF-1R磷酸化,IC50分别为13 nM, 6 nM 和 21 nM。BMS-754807作用于 IGF-1R-Sal, Rh41 和Geo细胞,抑制Akt磷酸化,IC50 分别为22 nM, 13 nM 和 16 nM。BMS-754807诱导Rh41细胞凋亡。[1] BMS-754807作用于IGF-Sal 细胞系,抑制IGF-1R (IC50 = 13nM) 和下游靶点Akt (IC50 = 22nM) 和MAPK(IC50 = 13nM) 的磷酸化。[2] 在儿科临床前期试验计划(PPTP)中,BMS-754807作用于23种细胞系,平均EC50值为0.62 µM。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
IGF-Sal NXjvNHY3U2mwYYPlJIF{e2G7 NUfrSY44cW6qaXLpeJMhfGinIIDoc5NxcG:{eXzheIlwdiCxZjDJS2YuOVJiKFnDOVAhRSBzM37NLUBidmRidHjlJIRwf26|dILlZY0hfGG{Z3X0d{BCc3RiKFnDOVAhRSB{Mn7NLUBidmRiTVHQT{ApUUN3MDC9JFE{dk1r MkTyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5N{iwNlQoRjF7N{e4NFI1RC:jPh?=
IGF-Sal NX;mPZlUT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MUjJR|UxRTdibl2= MlfxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5N{iwNlQoRjF7N{e4NFI1RC:jPh?=
CCRF-CEM (ALL) NEG2[nNIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NHTYbFN,PSEQvF2= M3nhcWROW09? NV7XOHRJUUN3ME2xMlI{QSEQvF2= NYTHXGZjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
PC3 NWqyNWt[T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MnfvglUh|ryP MWjEUXNQ MY\JR|UxRTBwOU[1JO69VQ>? NXvCem9GRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
JD NXHUSpg1T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NEi4R2R,PSEQvF2= NVr3[VRwTE2VTx?= NHOx[4RKSzVyPUCuN|kyKM7:TR?= NE\hfW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
DU145 NEjme4RIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M3\rNZ42KM7:TR?= MWrEUXNQ MVrJR|UxRTFwNE[1JO69VQ>? M1njN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
KAG M4XtZWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NE[z[FB,PSEQvF2= Ml;GSG1UVw>? NIjWV4FKSzVyPUGuOlY2KM7:TR?= NH;BN|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
K-562 (CML) NFTXZ|RIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= Mm\kglUh|ryP NH\OR5pFVVOR MnjiTWM2OD1{LkOwNkDPxE1? MnW1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
B6-P210 (Murine ALL) M4TVOGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 M4\2WZ42KM7:TR?= NELVdJZFVVOR NWW0[5J[UUN3ME2xMlI6OyEQvF2= M2frW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
LN CAP-FGC NX76[5pWT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NGfZfol,PSEQvF2= MYXEUXNQ NHfiOXhKSzVyPUGuOFM1KM7:TR?= NYLmXnBxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
VW NGn4bplIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M{S3bZ42KM7:TR?= M1LMbGROW09? NUfTb2d{UUN3ME2wMlAyQSEQvF2= Mn\vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
MV411 (B Myelomonocytic) NYXQ[GVQT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NIOx[Yt,PSEQvF2= NFHSVpFFVVOR Mm\mTWM2OD1yLkOzJO69VQ>? M1HTSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
MDA-PCa-2b NVjsOpNTT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M3zsXp42KM7:TR?= NGXOT|NFVVOR Ml;MTWM2OD1yLkC5PEDPxE1? M1njS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
LG Mlv5S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MoLxglUh|ryP NYq0cXEzTE2VTx?= M2K2PWlEPTB;MD6wN|gh|ryP MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
RS411 (B cell precursor-ALL) NF[1fFJIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MnTTglUh|ryP NUTsepRDTE2VTx?= NFy5[pdKSzVyPUCuNVAzKM7:TR?= NWS0V3hXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
22-r-1 MVnHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MUj+OUDPxE1? NWrnbpo4TE2VTx?= NHu4SWNKSzVyPUCuNVc2KM7:TR?= Ml7wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
5838 MmrES5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NYL0TlRbhjVizszN NH3xNY5FVVOR M{PpcWlEPTB;MD6wN|Qh|ryP Ml62QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
P388 (Murine) Mn7XS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MYH+OUDPxE1? NHnOO4hFVVOR M{XMXWlEPTB;ND6yO{DPxE1? NH3s[VY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
A2780/S NWrTPYtQT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MUj+OUDPxE1? MX7EUXNQ Mn;zTWM2OD1yLkGyNkDPxE1? MlrMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
RDES NWLvOoJHT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NYLSdHpThjVizszN Mo\2SG1UVw>? M1y1S2lEPTB;MD6wNVIh|ryP MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
B6-T315I (Murine B-ALL) NFHB[YtIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= Ml\QglUh|ryP MkniSG1UVw>? NGm2T5FKSzVyPUKuPFMh|ryP M1TKb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
TOV 112D MX3Hdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NGTBR3p,PSEQvF2= NHHqdZBFVVOR MXfJR|UxRTJwMUS2JO69VQ>? MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
TC32 M4T2Zmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NUPFe2RHhjVizszN M1vNZmROW09? NX7Ne5ZPUUN3ME2wMlAxQCEQvF2= NV3SOHFoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
HL60 (acute myelocytic) NWDmfWNpT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NYPmcZhNhjVizszN NFn6bG9FVVOR M1Hzd2lEPTB;MD6xNkDPxE1? M4DNeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
TOV 21G NF7SNo5Iem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M3u1Z542KM7:TR?= MXfEUXNQ MnzZTWM2OD12LkK3PUDPxE1? NVnSXVRSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
TC71 Mm[wS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NHe4Slh,PSEQvF2= NYXrcI9qTE2VTx?= NXe5RY9bUUN3ME2wMlAyPCEQvF2= M4TEWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
HPN-ALL (T-cell) M13GWmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MnTTglUh|ryP NEfMW|NFVVOR NH\kdpdKSzVyPUCuOVIh|ryP MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
A2780R MUTHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NIXDNWN,PSEQvF2= MmLoSG1UVw>? MVjJR|UxRTFwNU[0JO69VQ>? MomwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
Rh1 MnTXS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NHHtcIh,PSEQvF2= NIHEPHpFVVOR MVfJR|UxRTBwMEK3JO69VQ>? MkfWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
Kasumi-1 (acute myeloid) MUTHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MXv+OUDPxE1? NYL6XlZwTE2VTx?= MUXJR|UxRTBwMU[g{txO M3WwO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
sk-ov-3 NV;uWIhyT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MX7+OUDPxE1? M3\ZWGROW09? NGm2bHlKSzVyPUWuNUDPxE1? NW\hXG5VRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
ME MXPHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NFvQR|R,PSEQvF2= NVi5TYU3TE2VTx?= MljVTWM2OD1yLkCxOUDPxE1? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
L1210 (Murine lymphocytic) NYDLRY05T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MXj+OUDPxE1? Mo\KSG1UVw>? MkPETWM2OD1{LkO5JO69VQ>? NVy3Ro0xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
sw-626 MmizS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NEL1TJh,PSEQvF2= M1fTN2ROW09? NG\rOI9KSzVyPUKuN|A3KM7:TR?= MnrnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
CTR M13KZWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NGLk[JR,PSEQvF2= MWfEUXNQ NX7sWY5YUUN3ME2wMlI2OyEQvF2= NYHRTnNGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
ML2 (Myelomonocytic) MX7Hdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MYD+OUDPxE1? M2\1ZmROW09? NEXxTGNKSzVyPUCuNFkh|ryP NF;aWFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
ovcar-3 MUnHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MVv+OUDPxE1? MkjSSG1UVw>? MknWTWM2OD13IN88US=> M1TUXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
Rh36 NU\MdpN5T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NUPHb2E6hjVizszN MX\EUXNQ Mlv4TWM2OD1zLkSzNkDPxE1? MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
MOLM-13 (acute myeloid) NVzKcmxST3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M33LSZ42KM7:TR?= NX7zPVhuTE2VTx?= M{DMd2lEPTB;MD60NkDPxE1? M373WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
ovcar-4 NHXEc3FIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NHTFelR,PSEQvF2= NEDic5hFVVOR NGnSTVdKSzVyPUGg{txO MmH5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
Rh41 M3jz[2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NVfkSHI{hjVizszN MXvEUXNQ M4jWTWlEPTB;MD6wNFUh|ryP NH3vTm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
Mutz 2 (acute myeloid) MYTHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NVjZNJFVhjVizszN NWLHellnTE2VTx?= NVrNXFF5UUN3ME2xMlE2KM7:TR?= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
ovcar-5 MmX5S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NX\pNJZrhjVizszN NHPJR2ZFVVOR Mk[2TWM2OD1yLkC1JO69VQ>? MkLsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
RD1 NUe4ZoU3T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= Ml;rglUh|ryP M3;tZmROW09? M{nWSmlEPTB;MD6wOlgh|ryP M3\X[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
OCI-AML 2 (acute myeloid) MVfHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NUSwVnJrhjVizszN MmfXSG1UVw>? M3rOUWlEPTB;Mz6zN{DPxE1? M1rmVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
786-O NEDqS2RIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M3fHb542KM7:TR?= MnL3SG1UVw>? NWCyTFNIUUN3ME2xMlY1PyEQvF2= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
A673 MkTXS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NYDHbGh7hjVizszN MV;EUXNQ NH3CRZFKSzVyPUCuOFA5KM7:TR?= MlTUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
TALL-1 (T-cell) NH\id5hIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MUP+OUDPxE1? NYr5V|JwTE2VTx?= MYjJR|UxRTFwMkig{txO M2\KU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
151-B NXr3T3dtT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M{nzdZ42KM7:TR?= MUXEUXNQ MkTJTWM2OD1{Lk[3JO69VQ>? NFrwVm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
PFSK-1 NVfGZ3pYT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NWrLeZp6hjVizszN MmjOSG1UVw>? NV\mTWdDUUN3ME2wMlE{OiEQvF2= MnXWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
THP-1 NYHhXXIyT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NYPj[op5hjVizszN NYjneXJXTE2VTx?= M2XDPWlEPTB;Nj61PEDPxE1? NUSwSWxzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
HEK293 NE\rUnlIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MnfOglUh|ryP MmfrSG1UVw>? MoPVTWM2OD1yLkmxOUDPxE1? NFnV[2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
DAOY M2\QS2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NHPN[HB,PSEQvF2= MV\EUXNQ MWTJR|UxRTFwOUe5JO69VQ>? NELMTlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
SET2 M2LxbWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MX3+OUDPxE1? NHjTTplFVVOR M3mxWmlEPTB;MD6yPVgh|ryP NXLIeJVuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
HTB-46 NUHrPINWT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MXL+OUDPxE1? MYHEUXNQ M1XyWmlEPTB;NT6yOUDPxE1? MoDwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
SK-NAS MW\Hdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MnixglUh|ryP MWnEUXNQ MnzBTWM2OD1yLkS5O{DPxE1? NX2wOph{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
CTLL2 MlvPS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MXr+OUDPxE1? M3r5NGROW09? MVTJR|UxRjFwMECg{txO MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
HTB-47 MXXHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? M2nxN542KM7:TR?= M3ryR2ROW09? M4DtSmlEPTB;Mj6wOVYh|ryP MlnDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
LAN-1 NITyUZRIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MX7+OUDPxE1? M17JU2ROW09? NUf6fpRrUUN3ME2wMlA1KM7:TR?= MlP2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
ST486 NEfDV2tIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M3zDWJ42KM7:TR?= NEjQNHVFVVOR NXfWfGN2UUN3ME2xMlE6KM7:TR?= NFTVWVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
HS766T MYXHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MlTLglUh|ryP MXTEUXNQ MXTJR|UxRTJwMECxJO69VQ>? M32wN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
IMR-32 NED5RWpIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NWHrW4tXhjVizszN Mk[1SG1UVw>? Mlj6TWM2OD1yLkK2NUDPxE1? M2rlXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
Daudi (Burkitt's) Mk\rS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? M1K1R542KM7:TR?= NEjiNmtFVVOR MYXJR|UxRTJwNkO3JO69VQ>? NWS0Z4hvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
Aspc-1 NU[5RVRYT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MUf+OUDPxE1? NFHQfXJFVVOR NWTvXWRsUUN3ME2wMlM4QSEQvF2= Mm\IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
SK-NSH MUXHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NE\xW4V,PSEQvF2= MYjEUXNQ MmTkTWM2OD1yLkGzPUDPxE1? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
MEC-1 (Chronic B cell) NUDBOllZT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M3jkVZ42KM7:TR?= MVvEUXNQ MXvJR|UxRTJwNkO3JO69VQ>? NGi3cW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
Capan-2 M{P3W2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 M2LhcZ42KM7:TR?= NVHkRpNpTE2VTx?= MV7JR|UxRTFwN{e0JO69VQ>? Ml7DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
SHSY5Y NHnPN|VIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MoLzglUh|ryP M{j5[WROW09? NFPH[ldKSzVyPUCuNVA3KM7:TR?= NHvoUG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
U937 (Histioocytic) NVnIU5hkT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NVW0cHg{hjVizszN M3zrTWROW09? MXjJR|UxRjVwMECg{txO NXnVS41qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
Bxpc-1 NHGyXmxIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MYn+OUDPxE1? NEPlVGhFVVOR NVzZPVZHUUN3ME2xMlkzPCEQvF2= NH;LOmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
Bxpc-3 MYjHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MVv+OUDPxE1? MXjEUXNQ NWfLeWF7UUN3ME61MlAxKM7:TR?= MoLEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
HTB-92 MnjvS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NFnkN2l,PSEQvF2= NYexc|FnTE2VTx?= NGHZZ4tKSzVyPUGuNFIh|ryP NE\QWYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
OCI-LY10 (B-cell) M2Pvemdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 M174fp42KM7:TR?= MULEUXNQ NFfNWpNKSzVyPUCuOFUh|ryP MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
PANC-1 NF22O5pIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= Ml:3glUh|ryP M17TZWROW09? M3PM[GlEPTB-NT6wNEDPxE1? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
To184.T NELhUGdIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M1P6bZ42KM7:TR?= M1jwdmROW09? NHLJbmhKSzVyPUCuOFY6KM7:TR?= NXvCVWh2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
OCI-LY19 (B-cell) M2PQZmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 Mk\iglUh|ryP NUfPOIZRTE2VTx?= MX\JR|UxRTBwNDFOwG0> MkTpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
PANC-1 BM MWXHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MkHzglUh|ryP MVTEUXNQ M{LwS2lEPTB-NT6wNEDPxE1? MoTRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
SA-4 MoHaS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NFrSXYJ,PSEQvF2= NULxV5U1TE2VTx?= NUW5[3ptUUN3ME2xMlMxOSEQvF2= M1LFW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
RPMI 8226 NInVNZBIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MV;+OUDPxE1? NWG4RmtFTE2VTx?= MXrJR|UxRTFwMkmzJO69VQ>? MoXEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
HPAF-II NYfrZ3F7T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MYH+OUDPxE1? M4L1XmROW09? M4XNW2lEPTB;MD62OFQh|ryP M3zhZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
SHP-77 NVXF[WJoT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NUHEUo5whjVizszN M{TBSWROW09? M3vDT2lEPTB;MT64PFgh|ryP MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
U266 B1 NIfTRWRIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NI\mTZh,PSEQvF2= NUjUW5hjTE2VTx?= M{P1W2lEPTB;MT62Olkh|ryP M4e2[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
Hs700t MUXHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NYf3OJc{hjVizszN MlrZSG1UVw>? MWrJR|UxRTBwMkOxJO69VQ>? M4i4bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
NCI-446 M1HBOGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NGC2UGF,PSEQvF2= MnTNSG1UVw>? M4rtTWlEPTB;MT6xOVQh|ryP M4LZU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
H929 MmnKS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NWfpblB{hjVizszN MnKzSG1UVw>? NF3idJFKSzVyPUCuNFE1KM7:TR?= M{nrTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
PL45 MmOwS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NFv5Vmp,PSEQvF2= MoHwSG1UVw>? M3HHfGlEPTB;Mj6yOVUh|ryP NIPn[209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
NCI-H383 NIjIeGlIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NWDZTWt3hjVizszN NVHXR3FtTE2VTx?= MlHhTWM2OD53LkCwJO69VQ>? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
JJN3 M{jkNGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NV\aTYpohjVizszN MorpSG1UVw>? NIjOSVVKSzVyPUKuOFM{KM7:TR?= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
SU.86.86 M1PsZWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NFv6eHF,PSEQvF2= Mme2SG1UVw>? M4HMT2lEPTB;Mj62O|Ih|ryP NUT1SpoxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
H1299 NXXVRYMyT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M4HuVZ42KM7:TR?= NUXsPGlFTE2VTx?= M{LWb2lEPTB-NT6wNEDPxE1? MlTzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
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647-V MnT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJcohq[mm2aX;uJI9nKGi3bXHuJFY1Py2YIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTC0NU45QDN{IN88UU4> MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O|U1PDhxJ{7TRW5ITVJ:L3G+
PF-382 MkjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\oUGc{UW6qaXLpeIlwdiCxZjDoeY1idiCSRj2zPFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDR{LkCyOFIh|ryPLh?= MlO5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVc2PDR6Lze+V2FPT0WUPD;hQi=>
IST-SL1 M17hUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHe3TopKdmirYnn0bY9vKG:oIHj1cYFvKEmVVD3TUFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDR{LkOyOFch|ryPLh?= M4LVc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4PTR2OD:nQnNCVkeHUkyvZV4>
MKN7 NVLOfmx3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJcohq[mm2aX;uJI9nKGi3bXHuJG1MVjdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IESyMlQ6PzdizszNMi=> Mmq1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVc2PDR6Lze+V2FPT0WUPD;hQi=>
CP50-MEL-B MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJcohq[mm2aX;uJI9nKGi3bXHuJGNRPTBvTVXMMWIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDR{Lk[5NFEh|ryPLh?= NUTNe|E{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd3NES4M{c,W0GQR1XSQE9iRg>?
K052 M1jQ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT1eYdKdmirYnn0bY9vKG:oIHj1cYFvKEtyNUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ{NjB4OUig{txONg>? NGDoRos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzV2NEivK|5USU6JRWK8M4E,
23132-87 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrvTm9MUW6qaXLpeIlwdiCxZjDoeY1idiB{M{GzNk05PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iNEOuOVI5PiEQvF2u Mlm1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVc2PDR6Lze+V2FPT0WUPD;hQi=>
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Mewo NFmwSoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJcohq[mm2aX;uJI9nKGi3bXHuJG1mf29iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IES1MlU5PzhizszNMi=> NI\hWXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzV2NEivK|5USU6JRWK8M4E,
RMG-I NUDVZm1CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULKe|BMUW6qaXLpeIlwdiCxZjDoeY1idiCUTVetTUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDVwN{O3NkDPxE1w NFO1cHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzV2NEivK|5USU6JRWK8M4E,
BE-13 MmS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnsd5ZnUW6qaXLpeIlwdiCxZjDoeY1idiCERT2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDVwOUO5NkDPxE1w NXvI[4UxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd3NES4M{c,W0GQR1XSQE9iRg>?
SW684 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJcohq[mm2aX;uJI9nKGi3bXHuJHNYPjh2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTC0O{41QTZ7IN88UU4> NXzn[Y01RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd3NES4M{c,W0GQR1XSQE9iRg>?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-IGFIRRβ/InsRβ / IGFIRβ / p-AKT / AKT / p-ERK / ERK ; 

PubMed: 26136493     


(C) T4105 cells were treated with OSI-906 or BMS-754807 at indicated concentrations for 24 hours, lysed, and subjected to immunoblotting.

26136493
Growth inhibition assay
Cell viability; 

PubMed: 30754629     


Response of SK-CO-1 to various drugs and drug combinations.

30754629
体内研究 BMS-754807(12.5mg/kg,口服)作用于携带 IGF-1R-Sal肿瘤的裸鼠,抑制肿瘤和血清中IGF-1R磷酸化。BMS-754807作用于一组选定的上皮(IGF-1R-Sal, GEO, 和Colo205),造血(JJN3)和间质(RD1和Rh41)移植瘤模型,抑制肿瘤生长,肿瘤生长抑制率从53%至115%不等。[1] BMS-754807 (6.25 mg/kg) 作用于转基因的IGF-Sal肿瘤小鼠模型,完全抑制肿瘤生长,且抑制pIGF-1R 和 pAKT。BMS-754807与小鼠血浆和人类血浆的蛋白结合率分别为98.5% 和95.9%。BMS-754807 (25 mg/kg)作用于携带KT-5 (Wilms), KT-14 (rhabdoid), Rh28 (rhabdomyosarcoma), 和 OS-1移植瘤的小鼠模型,显著抑制肿瘤。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
- 合并

激酶抑制实验:

在体外激酶实验中使用重组人类 IGF-1受体酶测定BMS-754807,在生化实验中使用合成肽KKSRGDYMTMQIG 作为磷酸受体底物测定BMS-754807。在Ubottom 384孔板中使用 30 μL实验缓冲液 (100 mM Hepes pH 7.4, 10 mM MgCl2, 0.015% Brij35 and 4 mM DTT)来进行酶活测定。通过结合ATP,1.5 μM 荧光标记肽底物, 酶和BMS-754807而开始反应,反应持续60分钟。加入EDTA终止反应。通过电泳分离荧光底物和磷酸化产物,然后在Caliper LabChip 3000上分析反应混合物。通过对剂量反应曲线进行非线性回归分析而获得IC50值。
细胞实验:[1]
- 合并
  • Cell lines: IGF-1R-Sal, RH41 和 Geo 细胞系
  • Concentrations: 365 nM
  • Incubation Time: 72 小时
  • Method: 细胞按最佳密度培养在RPMI + GLUTAMAX培养基中,培养基中含有有10% 热灭活的胎牛血清(FBS),10mMHepes,青霉素和链霉素。BMS-754807处理细胞72小时后,通过测定3H-胸甘渗透到DNA中的程度而测评细胞增殖。结果表示为IC50。
    (Only for Reference)
动物实验:[1]
- 合并
  • Animal Models: 携带IGF-1R-Sal, GEO, Colo205, JJN3, RD1 或 Rh41 肿瘤的裸鼠
  • Dosages: 150 mg/kg
  • Administration: 口服
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 92 mg/mL (199.35 mM)
Water Insoluble
Ethanol '''92 mg/mL
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 461.49
化学式

C23H24FN9O

CAS号 1001350-96-4
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01525823 Completed Drug: BMS-754807 (IGR-IR/IR Inhibitor)|Drug: Metformin Healthy Volunteers Bristol-Myers Squibb February 2012 Phase 1
NCT00908024 Terminated Drug: BMS-754807|Drug: cetuximab (Erbitux®) Colorectal Cancer|Head and Neck Cancer|Neoplasm Metastasis Bristol-Myers Squibb October 2009 Phase 1|Phase 2
NCT00898716 Completed Drug: BMS-754807 Neoplasms Bristol-Myers Squibb September 2009 Phase 1
NCT00788333 Completed Drug: BMS-754807|Drug: trastuzumab (Herceptin®) Breast Cancer Bristol-Myers Squibb July 2009 Phase 1|Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

IGF-1R Signaling Pathway Map

IGF-1R Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID