BMS-754807

For research use only. Not for use in humans.

目录号:S1124

BMS-754807 Chemical Structure

CAS No. 1001350-96-4

BMS-754807是一种有效的IGF-1R/InsR可逆性抑制剂,在无细胞试验中IC50为1.8 nM/1.7 nM,对Met (c-Met),Aurora A/B,TrkA/B和Ron作用稍弱,对Flt3, Lck,MK2,PKA,PKC等几乎没有抑制活性。Phase 2。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 2211.3 现货
RMB 1480.09 现货
RMB 2214.12 现货
RMB 6299.66 现货
RMB 16953.3 现货
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客户使用Selleck生产的BMS-754807发表文献40篇:

产品安全说明书

IGF-1R抑制剂选择性比较

生物活性

产品描述 BMS-754807是一种有效的IGF-1R/InsR可逆性抑制剂,在无细胞试验中IC50为1.8 nM/1.7 nM,对Met (c-Met),Aurora A/B,TrkA/B和Ron作用稍弱,对Flt3, Lck,MK2,PKA,PKC等几乎没有抑制活性。Phase 2。
特性 胰岛素样生长因子-1R/IR家族激酶的多重抑制剂
靶点
Insulin Receptor [1]
(Cell-free assay)
IGF-1R [1]
(Cell-free assay)
TrkB [1]
(Cell-free assay)
Met [1]
(Cell-free assay)
TrkA [1]
(Cell-free assay)
1.7 nM 1.8 nM 4.1 nM 5.6 nM 7.4 nM
体外研究

BMS-754807 有效抑制人类多种不同组织来源的肿瘤细胞系的生长,包括间充质(尤文氏肉瘤,横纹肌肉瘤,神经母细胞瘤,和脂肪肉瘤),上皮(乳腺,肺,胰腺,结肠,和胃),和造血(多发性骨髓瘤和白血病)组织,IC50值从5 nM 到 365 nM。BMS-754807 抑制 IGF-1R-Sal 细胞和 RH41细胞增殖,IC50分别为7 nM 和5 nM。BMS-754807作用于IGF-1R-Sal, Rh41 和 Geo细胞,抑制IGF-1R磷酸化,IC50分别为13 nM, 6 nM 和 21 nM。BMS-754807作用于 IGF-1R-Sal, Rh41 和Geo细胞,抑制Akt磷酸化,IC50 分别为22 nM, 13 nM 和 16 nM。BMS-754807诱导Rh41细胞凋亡。[1] BMS-754807作用于IGF-Sal 细胞系,抑制IGF-1R (IC50 = 13nM) 和下游靶点Akt (IC50 = 22nM) 和MAPK(IC50 = 13nM) 的磷酸化。[2] 在儿科临床前期试验计划(PPTP)中,BMS-754807作用于23种细胞系,平均EC50值为0.62 µM。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
IGF-Sal NFfpXXlMcW6jc3WgZZN{[Xl? NIHpc3ZqdmirYnn0d{B1cGVicHjvd5Bpd3K7bHH0bY9vKG:oIFnHSk0yWiBqSVO1NEA:KDF|bl2pJIFv\CC2aHWg[I94dnO2cnXhcUB1[XKpZYTzJGFsfCBqSVO1NEA:KDJ{bl2pJIFv\CCPQWDLJEhKSzVyIE2gNVNvVSl? MmTHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5N{iwNlQoRjF7N{e4NFI1RC:jPh?=
IGF-Sal NHfHeI1Iem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M2XTd2lEPTB;NzDuUS=> MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd5OECyOEc,OTl5N{iwNlQ9N2F-
CCRF-CEM (ALL) NHnRfWRIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M1zuZp42KM7:TR?= M4rhOWROW09? NIrXeXZKSzVyPUGuNlM6KM7:TR?= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
PC3 M4i0d2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 M1XkR542KM7:TR?= NIqxfIRFVVOR NWHNRpZIUUN3ME2wMlk3PSEQvF2= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
JD NWHXfYR{T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M1fadp42KM7:TR?= M3zQOGROW09? M4fOXmlEPTB;MD6zPVEh|ryP MoDJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
DU145 MonmS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MUj+OUDPxE1? MnTWSG1UVw>? NFX0SXRKSzVyPUGuOFY2KM7:TR?= NIXxXmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
KAG NX7EUWIxT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MUf+OUDPxE1? MY\EUXNQ NEHsNopKSzVyPUGuOlY2KM7:TR?= NVjMUm1oRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
K-562 (CML) NH\pVYRIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= Mn7HglUh|ryP MVPEUXNQ NXO4Z3FGUUN3ME2yMlMxOiEQvF2= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
B6-P210 (Murine ALL) MoDJS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MorXglUh|ryP NIDZd|ZFVVOR M3;UO2lEPTB;MT6yPVMh|ryP MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
LN CAP-FGC MWjHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NFLqb5B,PSEQvF2= MnnaSG1UVw>? Mn7yTWM2OD1zLkSzOEDPxE1? M1nEOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
VW Mlz1S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? M3zJb542KM7:TR?= NEjHRnBFVVOR NUiyeGhJUUN3ME2wMlAyQSEQvF2= NGjreII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
MV411 (B Myelomonocytic) NXvvbHVvT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NGLafHF,PSEQvF2= MlLRSG1UVw>? NEntT2hKSzVyPUCuN|Mh|ryP MlnHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
MDA-PCa-2b NXLYdXllT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MWH+OUDPxE1? M1zRVGROW09? NYXmfY9wUUN3ME2wMlA6QCEQvF2= M{joflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
LG MYfHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NXTKWFNzhjVizszN NFrMPHJFVVOR NVX1[49nUUN3ME2wMlA{QCEQvF2= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
RS411 (B cell precursor-ALL) NV[3RZQ{T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NWC3O2F6hjVizszN M3rUWWROW09? NXXuTXk6UUN3ME2wMlExOiEQvF2= NYHqToZYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
22-r-1 MVHHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MkDIglUh|ryP M3W3eWROW09? M2fIUWlEPTB;MD6xO|Uh|ryP M33Bc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
5838 NXLhe5lIT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MWL+OUDPxE1? NXXwcmlkTE2VTx?= Mmq3TWM2OD1yLkCzOEDPxE1? MnLiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
P388 (Murine) MVzHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? Mnr3glUh|ryP Mn3ESG1UVw>? NEjCPZlKSzVyPUSuNlch|ryP NV\MVJEzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
A2780/S NGfyVGdIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M1v3bZ42KM7:TR?= Mm\PSG1UVw>? M1TQRmlEPTB;MD6xNlIh|ryP M17s[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
RDES NYDY[3dqT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NIewcFZ,PSEQvF2= NYDSSXZYTE2VTx?= MkX6TWM2OD1yLkCxNkDPxE1? MmTwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
B6-T315I (Murine B-ALL) M4fWNWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NG\3c25,PSEQvF2= NUH4fFE2TE2VTx?= NEXZbVBKSzVyPUKuPFMh|ryP MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
TOV 112D MmjvS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? M{\tSZ42KM7:TR?= Mn31SG1UVw>? MYPJR|UxRTJwMUS2JO69VQ>? NIjzbZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
TC32 M4ixdmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NXK2eHh4hjVizszN NFHjVZRFVVOR NEnGWHZKSzVyPUCuNFA5KM7:TR?= MmfrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
HL60 (acute myelocytic) MlezS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NI\uNFJ,PSEQvF2= MmDTSG1UVw>? MnH5TWM2OD1yLkGyJO69VQ>? MnX2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
TOV 21G M3rLZ2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MVz+OUDPxE1? MoTDSG1UVw>? MULJR|UxRTRwMke5JO69VQ>? NWH1S|h2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
TC71 MVvHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NUTxNpBohjVizszN NFX4R|NFVVOR MUjJR|UxRTBwMEG0JO69VQ>? MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
HPN-ALL (T-cell) MmrnS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NIC1c4N,PSEQvF2= MkXHSG1UVw>? MUXJR|UxRTBwNUKg{txO MnnFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
A2780R NHLMeHZIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= Mmf5glUh|ryP MUnEUXNQ NWWzWFFbUUN3ME2xMlU3PCEQvF2= NWDvV4dMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
Rh1 MofxS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? M{[2SJ42KM7:TR?= MXrEUXNQ M1L2WWlEPTB;MD6wNlch|ryP NGrUXmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
Kasumi-1 (acute myeloid) NXnzRY5IT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NVfW[FBwhjVizszN NIXLUZpFVVOR Mk\zTWM2OD1yLkG2JO69VQ>? NUXVR|dNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
sk-ov-3 NGnIb3lIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MnHxglUh|ryP MYHEUXNQ Mor6TWM2OD13LkGg{txO MkTaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
ME MWLHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? M1G0O542KM7:TR?= M1ewdGROW09? M1;jbmlEPTB;MD6wNVUh|ryP NYfU[G5vRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
L1210 (Murine lymphocytic) MWTHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MlryglUh|ryP MmrCSG1UVw>? NXzofXNOUUN3ME2yMlM6KM7:TR?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
sw-626 M2q4dmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NYjteW9YhjVizszN MWrEUXNQ NGTvUXJKSzVyPUKuN|A3KM7:TR?= NGLjZ3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
CTR M4TEcGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NYPad2NKhjVizszN MlrlSG1UVw>? MkLvTWM2OD1yLkK1N{DPxE1? NHm0RoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
ML2 (Myelomonocytic) M2qwOGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MlHvglUh|ryP MVrEUXNQ NV;UXmVPUUN3ME2wMlA6KM7:TR?= Mnr5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
ovcar-3 NV21c4Q6T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NVvDfVJnhjVizszN NV7iWoF{TE2VTx?= M2HvfGlEPTB;NTFOwG0> NUHQU4hKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
Rh36 MlfoS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MVz+OUDPxE1? NIXWWFdFVVOR NH7CS|ZKSzVyPUGuOFMzKM7:TR?= NWLIWGJFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
MOLM-13 (acute myeloid) MVjHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NFPtXlF,PSEQvF2= M{fSU2ROW09? MmHHTWM2OD1yLkSyJO69VQ>? NEjsdZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
ovcar-4 Mn3rS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NUfFZ3hxhjVizszN M334SWROW09? MYHJR|UxRTFizszN MmH1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
Rh41 NY\ycHFLT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MXT+OUDPxE1? MWTEUXNQ M{nrb2lEPTB;MD6wNFUh|ryP NETnV3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
Mutz 2 (acute myeloid) MlTBS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MY\+OUDPxE1? NUPNVmFSTE2VTx?= MmK0TWM2OD1zLkG1JO69VQ>? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
ovcar-5 M324[mdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NGToW49,PSEQvF2= NUe3VWR5TE2VTx?= NXzPNHNDUUN3ME2wMlA2KM7:TR?= M3fucVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
RD1 NYfjWFJsT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NUnsSIRChjVizszN MWPEUXNQ NXPXNI9CUUN3ME2wMlA3QCEQvF2= NGOycoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
OCI-AML 2 (acute myeloid) M{nnUWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 M3nkOZ42KM7:TR?= Mo[3SG1UVw>? M3PZXmlEPTB;Mz6zN{DPxE1? NH;q[2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
786-O NEXXZ3lIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MVn+OUDPxE1? NULhemZKTE2VTx?= MYjJR|UxRTFwNkS3JO69VQ>? MnfGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
A673 M{PreGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MkW1glUh|ryP NWfyRZNmTE2VTx?= NEPG[INKSzVyPUCuOFA5KM7:TR?= M1\tOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
TALL-1 (T-cell) M4DqeGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MlS1glUh|ryP NXfofY1STE2VTx?= NVTUWZozUUN3ME2xMlI5KM7:TR?= NVHCNGtVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
151-B NVPCd41ET3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NVL5eoI1hjVizszN MoDTSG1UVw>? M3jybGlEPTB;Mj62O{DPxE1? NXeyUIE3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
PFSK-1 MYTHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NYr6cGZ[hjVizszN MXjEUXNQ NHSxe4NKSzVyPUCuNVMzKM7:TR?= NUjIO2JZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
THP-1 M2D1Z2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NGnJeJd,PSEQvF2= NIHJWopFVVOR M4jYPWlEPTB;Nj61PEDPxE1? NGTTe4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
HEK293 MlrvS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MmS4glUh|ryP NUfOPI1rTE2VTx?= M1mwdGlEPTB;MD65NVUh|ryP MoXiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
DAOY MlK1S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NWnWbINmhjVizszN M3TycmROW09? NEmwO3hKSzVyPUGuPVc6KM7:TR?= NHnTeJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
SET2 NHLsSVZIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MmruglUh|ryP NEDzc3hFVVOR M1HUb2lEPTB;MD6yPVgh|ryP NXj4TZU3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
HTB-46 NWHYVlJ3T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M1TPcJ42KM7:TR?= M1vlW2ROW09? MmXZTWM2OD13LkK1JO69VQ>? NWLT[Gt[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
SK-NAS MVLHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? M4WxXZ42KM7:TR?= NFvJU3RFVVOR MULJR|UxRTBwNEm3JO69VQ>? MlvzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
CTLL2 NFTjWXFIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NGPKS|V,PSEQvF2= MWrEUXNQ NYDHTVFGUUN3ME6xMlAxKM7:TR?= NUL5PHNpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
HTB-47 M37UWWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NFfrN|Z,PSEQvF2= MlH4SG1UVw>? NIHSZVRKSzVyPUKuNFU3KM7:TR?= MoXCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
LAN-1 MoLBS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NWHyOVFShjVizszN MmXwSG1UVw>? MofvTWM2OD1yLkC0JO69VQ>? M2TsdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
ST486 NGf6dGtIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NHSzXZl,PSEQvF2= NGPaOGFFVVOR M3jafmlEPTB;MT6xPUDPxE1? M36wVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
HS766T NHn3e5hIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M1XsZp42KM7:TR?= NYGxR|hJTE2VTx?= MYfJR|UxRTJwMECxJO69VQ>? MkHBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
IMR-32 NGPGPGJIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MoXSglUh|ryP MV3EUXNQ MX7JR|UxRTBwMk[xJO69VQ>? NFzhOXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
Daudi (Burkitt's) M1[yW2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MWD+OUDPxE1? MX\EUXNQ M2DQc2lEPTB;Mj62N|ch|ryP Ml7XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
Aspc-1 NVvzbmtGT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NYi4TnBFhjVizszN MnuzSG1UVw>? MlrxTWM2OD1yLkO3PUDPxE1? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
SK-NSH NX3mSXVkT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NV;VUGZ2hjVizszN NVjEemc6TE2VTx?= NFHRUG5KSzVyPUCuNVM6KM7:TR?= MnfGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
MEC-1 (Chronic B cell) NWDZRm8yT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M1nSSp42KM7:TR?= M{C4UGROW09? M2C5emlEPTB;Mj62N|ch|ryP NWC3SVJyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
Capan-2 MYLHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NVGze5JJhjVizszN NVnue3dyTE2VTx?= NXf1RmNZUUN3ME2xMlc4PCEQvF2= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
SHSY5Y NXHTV5hrT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NUDaPFNQhjVizszN MnywSG1UVw>? MXLJR|UxRTBwMUC2JO69VQ>? Mni4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
U937 (Histioocytic) Mn7kS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NGnNWWV,PSEQvF2= NUThcnBqTE2VTx?= M{nLR2lEPTB-NT6wNEDPxE1? NHvQ[G89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
Bxpc-1 MULHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MUL+OUDPxE1? MkjCSG1UVw>? MUPJR|UxRTFwOUK0JO69VQ>? NGjUZYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
Bxpc-3 NI\JOWdIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MoHiglUh|ryP NEPWdmxFVVOR MoTBTWM2OD53LkCwJO69VQ>? MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
HTB-92 Mm\nS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? M3:2SJ42KM7:TR?= M1\uT2ROW09? MWfJR|UxRTFwMEKg{txO MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
OCI-LY10 (B-cell) M32yc2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MVH+OUDPxE1? MmnDSG1UVw>? MoK3TWM2OD1yLkS1JO69VQ>? NFe1[FE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
PANC-1 M3nUTGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 M2PCcJ42KM7:TR?= Ml;lSG1UVw>? MWXJR|UxRjVwMECg{txO NYPPcYt2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
To184.T M{TuXWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NYHLbIVihjVizszN NXLNO2pYTE2VTx?= MULJR|UxRTBwNE[5JO69VQ>? Mn3XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
OCI-LY19 (B-cell) M1LGVGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NFvTZo1,PSEQvF2= NHfuUpdFVVOR MUPJR|UxRTBwNDFOwG0> MlPuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
PANC-1 BM NFvTWZJIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NWXnSmRqhjVizszN M4XKTmROW09? MmTjTWM2OD53LkCwJO69VQ>? Ml;NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
SA-4 MVnHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MVL+OUDPxE1? Ml7hSG1UVw>? NFe4[VBKSzVyPUGuN|AyKM7:TR?= NXTFeYtrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
RPMI 8226 MlHhS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? M1nrOZ42KM7:TR?= NXfzOZlUTE2VTx?= MWnJR|UxRTFwMkmzJO69VQ>? NHSxXZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
HPAF-II NWLm[5FvT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MXT+OUDPxE1? M1XkNmROW09? MYTJR|UxRTBwNkS0JO69VQ>? MorTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
SHP-77 Ml:4S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MWf+OUDPxE1? NH[2O5dFVVOR NIDzb4hKSzVyPUGuPFg5KM7:TR?= NWDyV4ZkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
U266 B1 M1P1c2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MUP+OUDPxE1? NFPRNm1FVVOR M1L5emlEPTB;MT62Olkh|ryP MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
Hs700t NHX4dpdIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MkfKglUh|ryP MnPISG1UVw>? M3ixV2lEPTB;MD6yN|Eh|ryP MoXrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
NCI-446 M2TPTGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NH[0Xpp,PSEQvF2= NHLlZVRFVVOR MkPETWM2OD1zLkG1OEDPxE1? M1v4NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
H929 MYTHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MknTglUh|ryP M{O0bmROW09? NFfw[21KSzVyPUCuNFE1KM7:TR?= NWTCOY14RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
PL45 NHfQc4FIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NFXjT49,PSEQvF2= NGWxWWNFVVOR MlLWTWM2OD1{LkK1OUDPxE1? NVqzfY5RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
NCI-H383 Mlz5S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MnP1glUh|ryP MlXVSG1UVw>? MoL1TWM2OD53LkCwJO69VQ>? NWT2SJdGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
JJN3 M4e3b2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NYT0b4FJhjVizszN NWjvNGJ[TE2VTx?= MUfJR|UxRTJwNEOzJO69VQ>? NUm5NolHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
SU.86.86 NGraO4VIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MWD+OUDPxE1? NI[0d5FFVVOR Mo\yTWM2OD1{Lk[3NkDPxE1? NV3hdJB1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
H1299 NFr3VZBIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MVn+OUDPxE1? NFXjeFZFVVOR MmfXTWM2OD53LkCwJO69VQ>? NFrINnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
MDA-MB-468 MoH6S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? M2rjUZ42KM7:TR?= NYLNVZNFTE2VTx?= MWXJR|UxRTBwNUC0JO69VQ>? Ml71QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
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PF-382 NUGwTJU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJcohq[mm2aX;uJI9nKGi3bXHuJHBHNTN6MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gOFIvODJ2MjFOwG0v MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O|U1PDhxJ{7TRW5ITVJ:L3G+
IST-SL1 MnHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\0dlUzUW6qaXLpeIlwdiCxZjDoeY1idiCLU2StV2wyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB2Mj6zNlQ4KM7:TT6= NFPvRo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzV2NEivK|5USU6JRWK8M4E,
MKN7 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHyeFlKdmirYnn0bY9vKG:oIHj1cYFvKE2NTkegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQzNjR7N{eg{txONg>? M2XjZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4PTR2OD:nQnNCVkeHUkyvZV4>
CP50-MEL-B M{juVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nhcGlvcGmkaYTpc44hd2ZiaIXtZY4hS1B3MD3NSWwuSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iNEKuOlkxOSEQvF2u MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O|U1PDhxJ{7TRW5ITVJ:L3G+
K052 NITUVHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;MOmRKdmirYnn0bY9vKG:oIHj1cYFvKEtyNUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ{NjB4OUig{txONg>? MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O|U1PDhxJ{7TRW5ITVJ:L3G+
23132-87 MnzUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDZTY5pcWKrdHnvckBw\iCqdX3hckAzOzF|Mj24O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDNwNUK4OkDPxE1w NYXQU25WRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd3NES4M{c,W0GQR1XSQE9iRg>?
GAK M3Lsemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTxTY5pcWKrdHnvckBw\iCqdX3hckBISUtiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IES0MlEzPyEQvF2u M3j0blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4PTR2OD:nQnNCVkeHUkyvZV4>
Mewo NVvndVV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHUSlNKdmirYnn0bY9vKG:oIHj1cYFvKE2nd3:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ2NjV6N{ig{txONg>? NXXCWmszRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd3NES4M{c,W0GQR1XSQE9iRg>?
RMG-I NFPNcZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M12yVmlvcGmkaYTpc44hd2ZiaIXtZY4hWk2JLVmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ2Njd|N{Kg{txONg>? NXroU3o6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd3NES4M{c,W0GQR1XSQE9iRg>?
BE-13 NFrTNlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnP3TY5pcWKrdHnvckBw\iCqdX3hckBDTS1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gOFUvQTN7MjFOwG0v NIW0UVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzV2NEivK|5USU6JRWK8M4E,
SW684 MoK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHFTY5pcWKrdHnvckBw\iCqdX3hckBUXzZ6NDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gOFcvPDl4OTFOwG0v MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O|U1PDhxJ{7TRW5ITVJ:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-IGFIRRβ/InsRβ / IGFIRβ / p-AKT / AKT / p-ERK / ERK ; 

PubMed: 26136493     


(C) T4105 cells were treated with OSI-906 or BMS-754807 at indicated concentrations for 24 hours, lysed, and subjected to immunoblotting.

26136493
Growth inhibition assay
Cell viability; 

PubMed: 30754629     


Response of SK-CO-1 to various drugs and drug combinations.

30754629
体内研究 BMS-754807(12.5mg/kg,口服)作用于携带 IGF-1R-Sal肿瘤的裸鼠,抑制肿瘤和血清中IGF-1R磷酸化。BMS-754807作用于一组选定的上皮(IGF-1R-Sal, GEO, 和Colo205),造血(JJN3)和间质(RD1和Rh41)移植瘤模型,抑制肿瘤生长,肿瘤生长抑制率从53%至115%不等。[1] BMS-754807 (6.25 mg/kg) 作用于转基因的IGF-Sal肿瘤小鼠模型,完全抑制肿瘤生长,且抑制pIGF-1R 和 pAKT。BMS-754807与小鼠血浆和人类血浆的蛋白结合率分别为98.5% 和95.9%。BMS-754807 (25 mg/kg)作用于携带KT-5 (Wilms), KT-14 (rhabdoid), Rh28 (rhabdomyosarcoma), 和 OS-1移植瘤的小鼠模型,显著抑制肿瘤。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
- 合并

激酶抑制实验:

在体外激酶实验中使用重组人类 IGF-1受体酶测定BMS-754807,在生化实验中使用合成肽KKSRGDYMTMQIG 作为磷酸受体底物测定BMS-754807。在Ubottom 384孔板中使用 30 μL实验缓冲液 (100 mM Hepes pH 7.4, 10 mM MgCl2, 0.015% Brij35 and 4 mM DTT)来进行酶活测定。通过结合ATP,1.5 μM 荧光标记肽底物, 酶和BMS-754807而开始反应,反应持续60分钟。加入EDTA终止反应。通过电泳分离荧光底物和磷酸化产物,然后在Caliper LabChip 3000上分析反应混合物。通过对剂量反应曲线进行非线性回归分析而获得IC50值。
细胞实验:[1]
- 合并
  • Cell lines: IGF-1R-Sal, RH41 和 Geo 细胞系
  • Concentrations: 365 nM
  • Incubation Time: 72 小时
  • Method: 细胞按最佳密度培养在RPMI + GLUTAMAX培养基中,培养基中含有有10% 热灭活的胎牛血清(FBS),10mMHepes,青霉素和链霉素。BMS-754807处理细胞72小时后,通过测定3H-胸甘渗透到DNA中的程度而测评细胞增殖。结果表示为IC50。
    (Only for Reference)
动物实验:[1]
- 合并
  • Animal Models: 携带IGF-1R-Sal, GEO, Colo205, JJN3, RD1 或 Rh41 肿瘤的裸鼠
  • Dosages: 150 mg/kg
  • Administration: 口服
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 92 mg/mL (199.35 mM)
Water Insoluble
Ethanol '''92 mg/mL
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 461.49
化学式

C23H24FN9O

CAS号 1001350-96-4
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01525823 Completed Drug: BMS-754807 (IGR-IR/IR Inhibitor)|Drug: Metformin Healthy Volunteers Bristol-Myers Squibb February 2012 Phase 1
NCT00908024 Terminated Drug: BMS-754807|Drug: cetuximab (Erbitux®) Colorectal Cancer|Head and Neck Cancer|Neoplasm Metastasis Bristol-Myers Squibb October 2009 Phase 1|Phase 2
NCT00898716 Completed Drug: BMS-754807 Neoplasms Bristol-Myers Squibb September 2009 Phase 1
NCT00788333 Completed Drug: BMS-754807|Drug: trastuzumab (Herceptin®) Breast Cancer Bristol-Myers Squibb July 2009 Phase 1|Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

IGF-1R Signaling Pathway Map

IGF-1R Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID