Cyclopamine

For research use only. Not for use in humans.

目录号:S1146 别名: 11-deoxojervine 中文名称:环巴胺

Cyclopamine Chemical Structure

CAS No. 4449-51-8

Cyclopamine (11-deoxojervine)是一种特异性Hedgehog (Hh)信号通路拮抗剂,作用于Smoothened (Smo),在TM3Hh12细胞中IC50为46 nM。

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客户使用Selleck生产的Cyclopamine发表文献110篇:

产品安全说明书

Hedgehog/Smoothened抑制剂选择性比较

生物活性

产品描述 Cyclopamine (11-deoxojervine)是一种特异性Hedgehog (Hh)信号通路拮抗剂,作用于Smoothened (Smo),在TM3Hh12细胞中IC50为46 nM。
靶点
Smoothened [1]
(TM3Hh12 cells)
46 nM
体外研究

Cyclopamine 抑制Hedgehog信号通路, IC50 为46 nM, 且在[3H]Hh-Ag结合实验中,作用于CHO-K1细胞,抑制人类Smo受体活性,IC50为 280 nM。[1] Cyclopamine作用于表达Patched (PTCH) mRNA的肠源性肿瘤细胞,显著抑制 Hedgehog通路活性,这种作用存在剂量依赖性,且浓度为3 μM时,抑制肿瘤细胞生长,抑制达75-95%, 但是作用于不表达PTCH mRNA的结肠癌细胞没有效果,说明Cyclopamine 特定作用于Hedgehog 通路,且没有毒性。[2]通过与Smo直接作用而抑制Hedgehog信号,Cyclopamine (10 μM) 抑制SMOhigh Cyclopamine-反应细胞系L3.6sl和 Panc 05.04增殖,抑制达 75-80%,且使凋亡率提高2.5到 3.5倍,但是不影响BxPC3-SMOlow 细胞系。[3] Cyclopamine 处理E3LZ10.7细胞系,显著降低Snail mRNA,且提供E-钙粘着蛋白转录。Cyclopamine处理Hedgehog依赖型 L3.6pl 细胞,显著抑制浸润型细胞, 使转移细胞降低500多倍,但是对Hedgehog非依赖性细胞系Panc-1没有影响。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
OS-RC-2 Mne1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXUV4NzUUN3ME21Mlg3PjZizszN MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
DOHH-2 M1vyO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTlwM{W2PFkh|ryP NGf5XWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
no-10 M2\hfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPkUmlKSzVyPUmuPVA{QSEQvF2= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
LS-513 Mk\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLrbo9KSzVyPUGxMlM2PDdizszN MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
ALL-PO NFTaZpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPCXIpKSzVyPUGxMlc4OzRizszN M3ryN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
8-MG-BA NFTWW4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTF|LkGxNlMh|ryP NIrVWGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
RPMI-8402 NUPrRWJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHxd2R3UUN3ME2xOU45PTN5IN88US=> NV7sc5Q{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
EoL-1-cell NWe5R3RMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXwTWM2OD1zOD61PVQ5KM7:TR?= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
NALM-6 NGHsWnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTF7LkCxOlch|ryP NGHQVpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
DEL MnrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjKPWhKSzVyPUKwMlE1PzFizszN NUDPc4E3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
SR NWK0SVhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTJ|Lk[3NVUh|ryP MnrVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
697 M3i0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDKfGlrUUN3ME2yOk43OTV3IN88US=> NXLqNVdiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
COLO-829 NVO3[5dDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTJ4Lki0PFMh|ryP NEO5NJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
EVSA-T M1WwfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HOUWlEPTB;MkeuOVU3OSEQvF2= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
ATN-1 NVTqcWJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXUcnJNUUN3ME2zNU4zOzJ7IN88US=> NXvte5JPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
L-363 NUXme5hqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTNzLke0OlEh|ryP M4HLT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
LAMA-84 MnzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGe5c|dKSzVyPUOyMlUzOTFizszN MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
NOS-1 M1XINGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPPcFFKSzVyPUO0MlI6PTZizszN M1TafVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
BB30-HNC NV7uSGpuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vrUGlEPTB;M{SuN|MxPiEQvF2= Mn2xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
BC-1 MlLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX6wNFk1UUN3ME2zO{46PzR4IN88US=> NGLlOYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
IST-SL2 NWLZT45NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4[0fGlEPTB;M{iuNlI1KM7:TR?= NWHIc2xZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
D-392MG NHTrSWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnJfIxKSzVyPUSwMlIzOTVizszN MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
no-11 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLlTWM2OD12MD61OVIyKM7:TR?= NWq3ZZBlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
LC4-1 NV2w[INCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnHXolKSzVyPUSwMlg4OTZizszN NVnifHIzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
A388 NEjSe4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mne4TWM2OD12Mj61PFQ5KM7:TR?= MlfmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
NTERA-S-cl-D1 NIfpc3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTR{LkewO|Qh|ryP NXfKfXlnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
CESS NHrt[olIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEX0dWhKSzVyPUS0MlIzOzJizszN MoHlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
RS4-11 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTzR3FRUUN3ME20PU4xQTN6IN88US=> NGK0d4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
MS-1 NGC0fYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjaXJJ4UUN3ME21NE46OzVzIN88US=> NW\pdZl{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
CTV-1 M1X6Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYX6[GZ[UUN3ME21NU4xPzRizszN MmPrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
D-502MG MnvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHzTWM2OD13MT62NlcyKM7:TR?= MoXxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
ML-2 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILkR5pKSzVyPUWyMlkyQTVizszN Mm\aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
SK-NEP-1 NInBSlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPpWpdyUUN3ME21N{4{QTJ|IN88US=> Ml7LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
LOXIMVI M{nrXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjD[XVyUUN3ME21N{42QDh2IN88US=> NWfS[m5VRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
DJM-1 NEexS49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDtW|JKSzVyPUW2MlM{QTFizszN NEDRRVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
GI-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPCTWM2OD13Nj62NVQ6KM7:TR?= NHmwN3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
IST-MES1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrIWnVKSzVyPU[wMlU1QTNizszN M2XlOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
MV-4-11 MoXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\uc2lEPTB;NkCuOlU{QCEQvF2= MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
OVCAR-4 NFjJeHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\KTWM2OD14Mz61OlU4KM7:TR?= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
KE-37 MmXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV30fmF[UUN3ME22Ok4zPjZ6IN88US=> NFXuPGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
D-542MG NUTGUXFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTZ6LkSxN|Uh|ryP NFL3ZYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
MHH-PREB-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfZbGxKSzVyPUeyMlg1PDFizszN MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
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MC-CAR MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nyOmlEPTB;MkCyMlI2OyEQvF2= MmDSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
SNB75 Mn7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3qybWlEPTB;MkKxMlk1KM7:TR?= M13xZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
ES4 MmXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjpO5hYUUN3ME2yNlMvPzh|IN88US=> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
KARPAS-422 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmH2TWM2OD1{MkiuN|UzKM7:TR?= MoTwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
NCI-H1648 NIDxUFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:5NI9tUUN3ME2yNlkvPDh7IN88US=> M4nLZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
ES6 NWKxc4NGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLkTWM2OD1{M{muOFMh|ryP MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
KNS-81-FD NYi4dFlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXneHdKSzVyPUK0NU4yQTdizszN NXzLWlZIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
JAR NIXXXIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTJ3Nj6yNlUh|ryP NVnJToNVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
NB1 NVjh[Fg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HNWGlEPTB;Mk[wMlUyPiEQvF2= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
D-336MG M1TwUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLuTWM2OD1{NkCuOlk5KM7:TR?= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
BC-3 Mn:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPNOph1UUN3ME2yOlUvOTd6IN88US=> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
HCC2218 MlfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTJ4Nj60NVUh|ryP MkL3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
TE-9 M2LwbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPJV2Y5UUN3ME2yOlYvPjJ5IN88US=> M1;JSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
LB1047-RCC NH\XOYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTJ4Nj63OVMh|ryP NV7wV3lWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
CTB-1 NHT6d4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjoNII5UUN3ME2yOlkvQTd|IN88US=> M4THPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
NB7 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXiwW4ZDUUN3ME2yO|Eh|ryP NFrxN4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
ST486 NEfzeHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUe3cYhjUUN3ME2yO|cvPDF{IN88US=> NHjQZZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
HCC1187 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLGTWM2OD1{OEKuPFEyKM7:TR?= MoPMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
NCI-SNU-16 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrDTWM2OD1{OESuNlQ5KM7:TR?= MnrYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
COR-L279 M1HSZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJ7MT61PFQh|ryP MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
ES8 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHlTWM2OD1{OUSuNVgzKM7:TR?= Ml7XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
U-698-M NHzUXpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGS4N3lKSzVyPUK5PE4zPDNizszN M{DTOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
HEL MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGju[lBKSzVyPUOwPU4yPDlizszN MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
KINGS-1 NX7zPI85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorMTWM2OD1|MUCuOlc1KM7:TR?= M3LVb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
KY821 M1jOTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPUTWM2OD1|M{[uOVk2KM7:TR?= NILheGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
MZ1-PC MlXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH:4XFhKSzVyPUO0OU43OThizszN NYTlTHM4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
LS-411N NVzveoJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTN3ND62OkDPxE1? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
SIG-M5 M2\vOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWm2PXJ1UUN3ME2zOVkvPzh{IN88US=> Mk[xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
HT NHHhSoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTN4Nz63NVEh|ryP MmjFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
HC-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LkemlEPTB;M{[3Mlc5PyEQvF2= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
NCI-H1694 M1e4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEm1THBKSzVyPUO3Nk46OzRizszN MoX4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
BB65-RCC M1;pV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXWcGxUUUN3ME2zO|YvOjR3IN88US=> NFPFNG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
HAL-01 NYDKfHJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTN5OT64N|gh|ryP NGD0Wng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
ARH-77 MoryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HkcWlEPTB;M{m0MlAxQCEQvF2= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
MZ7-mel MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnMNoZlUUN3ME2zPVcvOjN|IN88US=> NFvabnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
SIMA NEfrVGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXYTWM2OD12MEOuPVM{KM7:TR?= M1fjclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
DG-75 MnzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jqWmlEPTB;NEG1MlY6QCEQvF2= NHe5Wms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
HUTU-80 M{PvTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TQ[WlEPTB;NEG5MlE5PSEQvF2= NILUeWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
KNS-42 M4n3eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTrTWM2OD12MkWuPFE2KM7:TR?= NYW5S3RzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
SH-4 NX3xRndHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXSzV2ZCUUN3ME20NlcvPTZ3IN88US=> NIno[VQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
L-540 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPLW|NzUUN3ME20N|EvODNzIN88US=> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
NB10 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXtfVBKSzVyPUS0NU4zOzRizszN NXrDNpl[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
ES1 M1vlTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTR3Mj63OVMh|ryP NYS4cVhGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
KMOE-2 NYfKbod1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzkTWM2OD12NU[uO|EyKM7:TR?= M1nlRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
MC116 NVfCNWZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvKNYlFUUN3ME20OVgvOTF4IN88US=> M2m2fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
RCC10RGB Mlq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzl[npyUUN3ME20OlAvODB3IN88US=> NFq5UJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
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Raji M4PyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPLXGxlUUN3ME20OlgvOTR|IN88US=> MkHwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
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neural precursor cells MnS0RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NHPFV5NCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIH7leZJidCCycnXjeZJ{d3JiY3XscJMh[nliY3;sc456KG[xcn3heIlwdiCjc4PhfUwhTUN3MDC9JFE{NjR2IN88UU4> NVHycYtpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NVc3OzFpPkG3OFE4PjNzPD;hQi=>
U87 NEWzVotEgXSxdH;4bYNqfHliYYPzZZk> NH\M[Y5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWQDdiY3XscJMh[XO|ZYPz[YQh[XNidnnhZoltcXS7IHnuJJBz\XOnbnPlJI9nKGKndHGg[4x2[3W{b37p[IF{\SxiSVO1NEA:KDF3LkWg{txONg>? M2HMTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUG2PVA1Lz5{MEGxOlkxPDxxYU6=
U87MG NFLJb4dCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NV7KU4pqPzJiaILz MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV6N13HJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGOgZZN{[XluIFnDOVAhRSB{Mj61JO69VS5? MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ{Nk[1O{c,OjJ{Mk[2OVc9N2F-
A549 Mmi0RY51cWOjbnPldkBie3OjeR?= M3Tj[2FvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIJ6KE2WUzDhd5NigSxiSVO1NEA:KDR7IN88UU4> M1P1NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MkKxPFczLz5zOEKyNVg4OjxxYU6=
DU145 M{HM[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3XzRVUhfU1? NYLyN2dvQTZiaILz M3fHfGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGRWOTR3IHPlcIx{KGG2IEWgeW0h[W[2ZYKgPVYhcHK| MmLUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh{NEmxNlUoRjF6MkS5NVI2RC:jPh?=
DU145 MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmPhNVAhfU1? M1fCc|k3KGi{cx?= MXnHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDEWVE1PSClZXzsd{BifCBzMDD1UUBi\nSncjC5OkBpenN? NEnyU5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEK0PVEzPSd-MUiyOFkyOjV:L3G+
HEK293 M{XzZWZ2dmO2aX;uJIF{e2G7 M4Ple2lvcGmkaYTpc44hd2ZiYnX0ZUBo[WyjY4Tvd4ll[XOnIHnuJGhGUzJ7MzDj[Yxtew>? Ml3vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2OUS3OlYoRjF5NEm0O|Y3RC:jPh?=
22Rv NEK5SZlHfW6ldHnvckBie3OjeR?= NFi5NmRT\WS3Y4Tpc44hd2ZiZYjwdoV{e2mxbjDv[kBRXEOKIH3SUmEhcW5iaIXtZY4hOjKUdjDj[Yxtew>? NYrIcopIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PVQ4PjZpPkG3OFk1PzZ4PD;hQi=>
PANC1 MVzGeY5kfGmxbjDhd5NigQ>? NHTISXUxNjJidV2= MlPaNlQhcHK| NEjjcVZKdmirYnn0bY9vKG:oIFjoM2dNUTFvbXXkbYF1\WRiUGTDTEBuWk6DIHX4dJJme3Orb36gbY4hcHWvYX6gVGFPSzFiY3XscJMh[XRiMD6yJJVOKGGodHXyJFI1KGi{czDifUBTXC2SQ2K= NWLoVZhrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0OVAyPzBpPkKwOFUxOTdyPD;hQi=>
PANC1 NV2zXItjTnWwY4Tpc44h[XO|YYm= Mn3INE41KHWP NWj4UodmOjRiaILz NWHpWnJlUW6qaXLpeIlwdiCxZjDIbE9IVElzLX3l[IlifGWmIGDUR2ghdVKQQTDlfJBz\XO|aX;uJIlvKGi3bXHuJHBCVkNzIHPlcIx{KGG2IECuOEB2VSCjZoTldkAzPCCqcoOgZpkhWlRvUFPS M{\jZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNEWwNVcxLz5{MES1NFE4ODxxYU6=
Shh Light2 MmDvSpVv[3Srb36gZZN{[Xl? NYDtS5gyPi5{NTD1US=> MlTDN|AhcHK| NWTPbFV1UW6qaXLpeIlwdiCxZjDOMZBidG2rdH;5cIF1\WRiU3joJIlvKG2xdYPlJHNpcCCOaXfoeFIh[2WubIOgZZQhPi5{NTD1UUBi\nSncjCzNEBpenNiYomg[olz\W[ueTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZk> NXLWenNDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxOVE4OzFpPkG5NVUyPzNzPD;hQi=>
U87MG M3Lm[WZ2dmO2aX;uJIF{e2G7 MoD0NVAhfU1? NGLOboY1KGi{cx?= MoXPTY5pcWKrdHnvckBw\iCKZXTn[Yhw\yC|aXfuZYxqdmdicHH0bJdigSCrbjDoeY1idiCXOEfNS{Bk\WyuczDhd5Nme3OnZDDhd{Bld3ewIILl[5Vt[XSrb36gc4YhT2yrMTDheEAyOCC3TTDh[pRmeiB2IHjyd{BjgSCUVD3QR3Ih[W6jbInzbZM> NXq4XYVzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNlY3PTdpPkKyNlI3PjV5PD;hQi=>
HEK293 MV\GeY5kfGmxbjDhd5NigQ>? M3PtRVUhfU1? Ml3lNVAhcHK| MoHxSIl{eGyjY3Xt[Y51KG:oIFLPSGlRYS2leXPsc5BidWmwZTDmdo9uKGi3bXHuJHNudyCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGG2IEWgeW0hdWWjc4Xy[YQh[W[2ZYKgNVAhcHK|IHL5JGRCWElic4ThbY5qdmdiYnHz[YQh\my3b4Lld4NmdmOnIH3pZ5Jwe2OxcHnjJIF{e2G7 NHH6[JA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{ezOlA3Oyd-Mke3N|YxPjN:L3G+
HEK293 MmrrSpVv[3Srb36gZZN{[Xl? NHjNcXo2KHWP M3HF[|ExKGi{cx?= M4fFd2Rqe3CuYXPlcYVvfCCxZjDCU2RKWFlvY4njcI9x[W2rbnWg[pJwdSCqdX3hckBUdW9iZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjdDC1JJVOKG2nYYP1doVlKGGodHXyJFExKGi{czDifUBHSUOVIHHuZYx6e2m| MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd|NkC2N{c,Ojd5M{[wOlM9N2F-
C3H10T1/2 MlLRSpVv[3Srb36gZZN{[Xl? M2\BPVU2NjVidH:gOFUxOCCwTR?= M121dmNwdXCndHn0bZZmKGmwaHnibZRqd25ib3[gV41wKGmwIH3veZNmKEN|SEGwWFEwOiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJHNCTy2rbnT1Z4VlKEeuaUGgeJJidnOlcnnweIlwdmGuIHHjeIl3cXS7IHH0JFU2NjVidH:gOFUxOCCwTTDifUByWEOUIHHuZYx6e2m| MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB5NEW0NUc,OjNyN{S1OFE9N2F-
U2OS MWTGeY5kfGmxbjDhd5NigQ>? M1rrU|UhfU1? MW[2JIhzew>? MmjlRY51[WexbnnzeEBi[3Srdnn0fUBifCClaHnt[ZJq[yCVbX:gOlM{KG23dHHueEBmgHC{ZYPz[YQhcW5iVULPV{Bk\WyuczDjc4V5eHKnc4Ppcoch[mW2YTDhdpJme3SrbkKtS2ZRKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhcW62cnHj[YxtfWyjcjDi[ZRiKGG{cnXzeIlvOi2JRmCgZYdoemWpYYTlJIZwem2jdHnvckBifCB3IIXNJIFnfGW{IE[gbJJ{KGK7IHPvcoZw[2GuIH3pZ5Jwe2OxcIm= MnTQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyNkO1NlIoRjJ|ME[zOVIzRC:jPh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Snail / E-cadherin / Slug / Vimentin ; 

PubMed: 26859575     


SW1736 and WRO82 cells were incubated in the presence of vehicle (0.5% DMSO) or the indicated concentrations of cyclopamine or GANT61 for 72 hr. The cells were harvested and analyzed for the expression of several genes involved in EMT.

Gli1 / TGF-β1 / CXCR4; 

PubMed: 26137001     


Western blotting demonstrated that Gli1, TGF-β1 and CXCR4 protein expression levels were downregulated in the AGS cells treated with cyclopamine for 24 h.

NF-κB / Cyclin D1 / MMP2 / MMP9; 

PubMed: 23599805     


Whole cell lysates were prepared, and 50 μg proteins were resolved using SDS-PAGE, followed by immunoblotting with the indicated specific antibodies against NF-κB, cyclin D1, MMP2 and MMP9. 

26859575 26137001 23599805
Immunofluorescence
PCNA / β-catenin; 

PubMed: 28747625     


Immunofluorescence images demonstrating the distribution of PCNA or β-catenin in EH cells pre-treated with cyclopamine in presence and absence of estrogen for 24 h. Experiments were repeated at least three times.

Vimentin; 

PubMed: 24553082     


Vimentin protein expression was reduced following treatment with cyclopamine (20 μmol/L; 72 h), detected by immunocytochemistry.

28747625 24553082
体内研究 Cyclopamine 每天按50 mg/kg剂量处理小鼠,持续22天,消除HUCCT1移植瘤,且没有明显副作用。[2] Cyclopamine 按1.2 mg剂量处理Panc 05.04和 L3.6sl驱动的肿瘤7天,前者诱导明显的肿瘤细胞凋亡,后者降低肿瘤质量,降低达50-60%,但是作用于BxPC3-SMOlow肿瘤没有效果。[3] Cyclopamine单独处理E3LZ10.7 和L3.6pl移植瘤,显著抑制肿瘤转移,且和 Gemcitabine联用处理,完全废除转移。[4]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
- 合并

激酶实验:

Gli-Luc实验测定Hh 信号通路末期, 即使用荧光素酶进行读数,测定Gli的转录调控。Cyclopamine 在DMSO中连续稀释用于实验,然后加到空的实验板上。TM3Hh12 细胞(TM3 细胞含Hh反应受体基因结构 pTA-8xGli-Luc) 悬浮在含5% FBS 和15 mM Hepes pH 7.3的F12 Ham’s/DMEM (1:1)培养基上, 加到实验板上,与Cyclopamine在37oC下温育30分钟左右。1 nM Hh-Ag 1.5 加到实验板上,然后在37oC下温育。48小时后,在实验板中加入Bright-Glo或MTS,然后在492 nm处测定发光度或吸光度。通过分析反应曲线,使用R统计软件包测定IC50值。
细胞实验:[2]
- 合并
  • Cell lines: SEG1, OE33, KYAE, KYSE180, SNU1, AGS, SNU16, NCI-N-87, HUCCT1, PANC1, PL5, PL6, BXPC3, HS766T, KYSE150, GBD1, DLD1, 和HCT116
  • Concentrations: 溶于DMSO, 终浓度为3 μM
  • Incubation Time: 4天
  • Method: 在96孔板上,用Cyclopamine 处理细胞。通过MTS实验测定细胞活力。进行CellTiter96比色测定,进行2和4天,然后在490 nm处通过测定光密度而测定存活细胞。
    (Only for Reference)
动物实验:[2]
- 合并
  • Animal Models: 皮下注射HUCCT1细胞的无胸腺裸鼠
  • Dosages: 50 mg/kg/day
  • Administration: 皮下注射处理
    (Only for Reference)

溶解度 (25°C)

体外 DMF 10 mg/mL warmed (24.29 mM)
Ethanol 2 mg/mL warmed (4.85 mM)
DMSO Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 411.62
化学式

C27H41NO2

CAS号 4449-51-8
储存条件 粉状
溶于溶剂
别名 11-deoxojervine

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    How to reconstitute the compound for in vivo use in mice?

  • 回答:

    One paper dissolved this drug in DMSO, and diluted in saline: Berman DM, et al. Nature, 2003, 425(6960), 846-851. Alternatively, you can try this vehicle: 10% DMSO+30% PEG 300+5% Tween 80+ddH2O for P.O. When preparing the solution, please dissolve the compound in DMSO clearly first. Then add PEG300 and Tween, after they mixed well, dilute with water.

Hedgehog/Smoothened Signaling Pathway Map

Hedgehog/Smoothened Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID