Cyclopamine

For research use only. Not for use in humans.

目录号:S1146 别名: 11-deoxojervine 中文名称:环巴胺

Cyclopamine Chemical Structure

CAS No. 4449-51-8

Cyclopamine (11-deoxojervine)是一种特异性Hedgehog (Hh)信号通路拮抗剂,作用于Smoothened (Smo),在TM3Hh12细胞中IC50为46 nM。

规格 价格 库存 购买数量  
RMB 1227.56 现货
RMB 3037.37 现货
RMB 3833.48 现货
有超大折扣

今日订购,明日送达,全国免运费!

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Cyclopamine发表文献94篇:

产品安全说明书

Hedgehog/Smoothened抑制剂选择性比较

生物活性

产品描述 Cyclopamine (11-deoxojervine)是一种特异性Hedgehog (Hh)信号通路拮抗剂,作用于Smoothened (Smo),在TM3Hh12细胞中IC50为46 nM。
靶点
Smoothened [1]
(TM3Hh12 cells)
46 nM
体外研究

Cyclopamine 抑制Hedgehog信号通路, IC50 为46 nM, 且在[3H]Hh-Ag结合实验中,作用于CHO-K1细胞,抑制人类Smo受体活性,IC50为 280 nM。[1] Cyclopamine作用于表达Patched (PTCH) mRNA的肠源性肿瘤细胞,显著抑制 Hedgehog通路活性,这种作用存在剂量依赖性,且浓度为3 μM时,抑制肿瘤细胞生长,抑制达75-95%, 但是作用于不表达PTCH mRNA的结肠癌细胞没有效果,说明Cyclopamine 特定作用于Hedgehog 通路,且没有毒性。[2]通过与Smo直接作用而抑制Hedgehog信号,Cyclopamine (10 μM) 抑制SMOhigh Cyclopamine-反应细胞系L3.6sl和 Panc 05.04增殖,抑制达 75-80%,且使凋亡率提高2.5到 3.5倍,但是不影响BxPC3-SMOlow 细胞系。[3] Cyclopamine 处理E3LZ10.7细胞系,显著降低Snail mRNA,且提供E-钙粘着蛋白转录。Cyclopamine处理Hedgehog依赖型 L3.6pl 细胞,显著抑制浸润型细胞, 使转移细胞降低500多倍,但是对Hedgehog非依赖性细胞系Panc-1没有影响。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
OS-RC-2 NXHKfIFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml76TWM2OD13Lki2OlYh|ryP MlHlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
DOHH-2 Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlj3TWM2OD17LkO1Olg6KM7:TR?= M2WzSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
no-10 M2rsTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLZTWM2OD17LkmwN|kh|ryP M3zKNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
LS-513 NXm3SGF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mof4TWM2OD1zMT6zOVQ4KM7:TR?= NX7icVRxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
ALL-PO NUXZZlltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3wV5dLUUN3ME2xNU44PzN2IN88US=> MlX2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
8-MG-BA MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\ITWM2OD1zMz6xNVI{KM7:TR?= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
RPMI-8402 Mmn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfiVmVKSzVyPUG1Mlg2OzdizszN NHi1dpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
EoL-1-cell NVjEZ2pDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEe2NWNKSzVyPUG4MlU6PDhizszN NXHTTplxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
NALM-6 NH72TnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvUTWM2OD1zOT6wNVY4KM7:TR?= MkXhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
DEL MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoD3TWM2OD1{MD6xOFcyKM7:TR?= MoPqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
SR MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXDbFVKSzVyPUKzMlY4OTVizszN MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
697 M1XST2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\4TWM2OD1{Nj62NVU2KM7:TR?= NEPNbIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
COLO-829 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PZS2lEPTB;Mk[uPFQ5OyEQvF2= Ml7MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
EVSA-T NXTHeZl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nMT2lEPTB;MkeuOVU3OSEQvF2= NID6fYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
ATN-1 NUnJRm5[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPLTWM2OD1|MT6yN|I6KM7:TR?= NULI[nZ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
L-363 Mk[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTNzLke0OlEh|ryP MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
LAMA-84 NI\0RXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr3VGVKSzVyPUOyMlUzOTFizszN MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
NOS-1 NHy4cZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPXTWM2OD1|ND6yPVU3KM7:TR?= NX3YclZJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
BB30-HNC NUDJeoZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFW4TWNKSzVyPUO0MlM{ODZizszN NEXpXWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
BC-1 NHzoeGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTN5Lkm3OFYh|ryP NVe2[3N{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
IST-SL2 NVrvNlYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLmdWJvUUN3ME2zPE4zOjRizszN NHXiO409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
D-392MG MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHyc4pKSzVyPUSwMlIzOTVizszN M13QT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
no-11 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3f1eGlEPTB;NECuOVUzOSEQvF2= NU\QU4F1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
LC4-1 Mnn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;PTWM2OD12MD64O|E3KM7:TR?= Mn7yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
A388 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTR{LkW4OFgh|ryP MmDGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
NTERA-S-cl-D1 Mn\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF[1PJRKSzVyPUSyMlcxPzRizszN MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
CESS NULPPXJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHXTWM2OD12ND6yNlMzKM7:TR?= NYH6UFMxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
RS4-11 M3P2TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17vcWlEPTB;NEmuNFk{QCEQvF2= Mli4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
MS-1 NFfDTZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LVS2lEPTB;NUCuPVM2OSEQvF2= M{\0bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
CTV-1 M4LuOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDpTWM2OD13MT6wO|Qh|ryP NF3ZPWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
D-502MG NVf1Vm5qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVT3TZp5UUN3ME21NU43OjdzIN88US=> NYOzPHBERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
ML-2 NHfDc3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jLXWlEPTB;NUKuPVE6PSEQvF2= M37XfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
SK-NEP-1 NGf5NopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfYPFdKSzVyPUWzMlM6OjNizszN MljqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
LOXIMVI MnzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU[xWWpuUUN3ME21N{42QDh2IN88US=> NH22NYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
DJM-1 M2C0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTV4LkOzPVEh|ryP NGTJRVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
GI-1 NWDOUWdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjoTWM2OD13Nj62NVQ6KM7:TR?= MlHTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
IST-MES1 M{fvNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHMXXpKSzVyPU[wMlU1QTNizszN M2XBcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
MV-4-11 M2O0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnu0TWM2OD14MD62OVM5KM7:TR?= NUf5XIpTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
OVCAR-4 NUezO|VET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHZT2hKSzVyPU[zMlU3PTdizszN M1HUclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
KE-37 M3PTN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlW4TWM2OD14Nj6yOlY5KM7:TR?= M13NS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
D-542MG M{n3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PQVWlEPTB;NkiuOFE{PSEQvF2= NFraPWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
MHH-PREB-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFi2ZYJKSzVyPUeyMlg1PDFizszN M1z2fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
MRK-nu-1 NF;5RlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\MeWlEPTB;N{OuOFcxPSEQvF2= NWXFPHJ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
D-247MG MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\N[ItKSzVyPUezMlU1PDJizszN MlzHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
OCI-AML2 NUeycWFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TuRmlEPTB;N{[uPVM3QSEQvF2= MlnZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
LP-1 NUj0bFYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\QTWM2OD16Mj64O|MyKM7:TR?= Ml\1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
HCC1599 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHq3NFNKSzVyPUi0MlI5OzdizszN MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
KARPAS-45 M{PiVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTh2Lk[5PVIh|ryP NYDVSpFJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
BE-13 M1XXcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnkbnBiUUN3ME25PU4xPDd5IN88US=> NUDzcpdMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
GCIY NWfpNJBLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYD1cY9yUUN3ME25PU4xQTV2IN88US=> MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
BV-173 NHjVToNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTFyMD6zNlUh|ryP NF;WV|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
LB2518-MEL Mli0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LS[2lEPTB;MUCwMlc5QSEQvF2= M4\zRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
KS-1 NXWy[2tUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHyU4VDUUN3ME2xNFEvPjN7IN88US=> NWPrT3pqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
MOLT-16 M1rXbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\j[WlEPTB;MUC0Mlk5PiEQvF2= MmjVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
NCI-H1770 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPLTWM2OD1zMEiuO|g1KM7:TR?= NVfaVmdCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
NCI-H82 NFrwT3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37zVmlEPTB;MUGwMlk4PiEQvF2= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
NCCIT NVPq[lA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTFzMj61Nlkh|ryP M3vQOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
KALS-1 NF7uS4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXqN|BKSzVyPUGxOU46PDFizszN MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
LB2241-RCC NX;Pd|UxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETUXFZKSzVyPUGxOk43PzlizszN Ml3yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
HH NHHBcYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHPWJhKSzVyPUGxO{4{QTVizszN M2HZ[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
HD-MY-Z NIO1W|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\kVFdkUUN3ME2xNVgvPDh6IN88US=> NWrWOXM5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
EB-3 NH7o[o1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTF{Mz6wPVQh|ryP M2jyUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
BL-70 MoLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPiTWM2OD1zMkOuNVI4KM7:TR?= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
K-562 Mk\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTF{Nj6yOFUh|ryP NUPjWVhPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
HT-144 NEi5fm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;nNJBjUUN3ME2xN|MvOTZ2IN88US=> NInmWIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
PF-382 NUHXVGZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXlfJpKSzVyPUGzOE4{PjFizszN NVzjd5hmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
RPMI-8226 NEDabYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTF|NT6wOFUh|ryP NH7VfIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
NCI-H1355 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moj1TWM2OD1zM{WuOVg4KM7:TR?= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
LXF-289 NUjjXGhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17FVmlEPTB;MUO5Mlc5OSEQvF2= MljSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
NCI-H69 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnmwTWM2OD1zNEKuPVMzKM7:TR?= Ml7rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
SK-MEL-1 NYXkRYh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUL5[W4{UUN3ME2xOFcvOTNizszN MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
KARPAS-299 NU\wXYtnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfoWnRCUUN3ME2xOFkvOTJizszN MmixQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
GB-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIC0bYxKSzVyPUG0PU4{OjJizszN NW[5[mxIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
CMK MlTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTF2OT61NVUh|ryP NX7rVFQ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
MPP-89 MlXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEi0PHBKSzVyPUG1Ok4xOzVizszN NUfodJRJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
KU812 M2ezXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPlTWM2OD1zNkGuPVAzKM7:TR?= NIXINIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
REH MkXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\6UIR1UUN3ME2xOlIvOTJ3IN88US=> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
NEC8 NV32WHpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHaTWM2OD1zNkWuNFI3KM7:TR?= NG\UXI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
KP-N-YS NH;LTpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTF4OD6zPVUh|ryP M3WwOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
Ramos-2G6-4C10 M1vCWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fVdmlEPTB;MU[5MlkyPSEQvF2= M2j0ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
Becker MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLYTWM2OD1zN{SuNVgh|ryP MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
LB647-SCLC NYnkOHhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS4OmVMUUN3ME2xO|UvQDR3IN88US=> MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
LU-139 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnUcop3UUN3ME2xO|gvODF7IN88US=> MoLBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
QIMR-WIL M{S5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTF5OT62OFYh|ryP NFf2cZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
NCI-H1395 NVfzb2FIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\3UJR[UUN3ME2xO|kvQTl4IN88US=> MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
NOMO-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrDSodKSzVyPUG4Nk45PSEQvF2= M{m4NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
GI-ME-N M1rOb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\zXnJnUUN3ME2xPFcvQTZ7IN88US=> MoHwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
KMS-12-PE NV7UdmVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HqVmlEPTB;MUi5MlI4OyEQvF2= NV\aO49kRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
Daudi M3Hhdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\PTWM2OD1zOUGuNVI5KM7:TR?= M4[zb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
LB996-RCC MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLNN2hxUUN3ME2xPVEvPjl7IN88US=> MlS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
NCI-H2107 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPNdGlkUUN3ME2xPVMvPzN7IN88US=> MofpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
SK-PN-DW MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTF7ND63NVkh|ryP MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
MC-CAR M4HQUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLxN4hJUUN3ME2yNFIvOjV|IN88US=> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
SNB75 M2\6UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXsW|ZKSzVyPUKyNU46PCEQvF2= MlfjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
ES4 MkfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml2xTWM2OD1{MkOuO|g{KM7:TR?= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
KARPAS-422 NV\acXhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3i0fWlEPTB;MkK4MlM2OiEQvF2= M3j1bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
NCI-H1648 M3:we2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnj3TWM2OD1{MkmuOFg6KM7:TR?= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
ES6 NGTWfYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n4V2lEPTB;MkO5MlQ{KM7:TR?= NYS2do5LRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
KNS-81-FD NV\BWm85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PqcGlEPTB;MkSxMlE6PyEQvF2= M1f4d|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
JAR M4\pdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfyV4pKSzVyPUK1Ok4zOjVizszN NVnDV3BSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
NB1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf6foxlUUN3ME2yOlAvPTF4IN88US=> NGP5SXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
D-336MG M3rwTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTtTWM2OD1{NkCuOlk5KM7:TR?= MmrFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
BC-3 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV[2XYNUUUN3ME2yOlUvOTd6IN88US=> MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
HCC2218 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mon0TWM2OD1{Nk[uOFE2KM7:TR?= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
TE-9 NWjROZBMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHn0dlZKSzVyPUK2Ok43OjdizszN Mm\zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
LB1047-RCC MoLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzaTHB2UUN3ME2yOlYvPzV|IN88US=> M3zJZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
CTB-1 MoO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlq1TWM2OD1{NkmuPVc{KM7:TR?= M{i4S|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
NB7 NFKwOGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULWS44xUUN3ME2yO|Eh|ryP NXrCXFJlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
ST486 NGXDbXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJ5Nz60NVIh|ryP MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
HCC1187 NHLCN5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTJ6Mj64NVEh|ryP NWixenl6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
NCI-SNU-16 M3;j[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fMS2lEPTB;Mki0MlI1QCEQvF2= M3vp[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
COR-L279 NF3Se49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fk[WlEPTB;MkmxMlU5PCEQvF2= NUXwTlNGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
ES8 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrLcYpKSzVyPUK5OE4yQDJizszN MkL2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
U-698-M MnT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJ7OD6yOFMh|ryP MojVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
HEL MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH[1eJVKSzVyPUOwPU4yPDlizszN MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
KINGS-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTNzMD62O|Qh|ryP MmnWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
KY821 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTN|Nj61PVUh|ryP MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
MZ1-PC MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTN2NT62NVgh|ryP MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
LS-411N M2LQcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLsNpRLUUN3ME2zOVQvPjZizszN MnXBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
SIG-M5 MojsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjkSFJKSzVyPUO1PU44QDJizszN NX\kRmdZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
HT NXzKTGdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfrTWM2OD1|NkeuO|EyKM7:TR?= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
HC-1 NVPkXZhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\XTWM2OD1|NkeuO|g4KM7:TR?= M3LwZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
NCI-H1694 NXnORYg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Tr[GlEPTB;M{eyMlk{PCEQvF2= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
BB65-RCC NWrCb5hTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTN5Nj6yOFUh|ryP MoTMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
HAL-01 NEDhZWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moj1TWM2OD1|N{muPFM5KM7:TR?= NUPwSopYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
ARH-77 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\jTYtvUUN3ME2zPVQvODB6IN88US=> NGLnS2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
MZ7-mel M1i0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\jTWM2OD1|OUeuNlM{KM7:TR?= M4jTNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
SIMA NWHEVXRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3BWlNnUUN3ME20NFMvQTN|IN88US=> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
DG-75 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnLOYxQUUN3ME20NVUvPjl6IN88US=> MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
HUTU-80 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTRzOT6xPFUh|ryP NHPKd|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
KNS-42 NITuW25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPZ[FNyUUN3ME20NlUvQDF3IN88US=> NUWwbnF3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
SH-4 M1jQXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2WyXGlEPTB;NEK3MlU3PSEQvF2= NY\QfJdsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
L-540 M3jp[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlS4TWM2OD12M{GuNFMyKM7:TR?= MkHFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
NB10 NIDEfIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2e3V2lEPTB;NESxMlI{PCEQvF2= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
ES1 MnjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDSTWM2OD12NUKuO|U{KM7:TR?= M4TkWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
KMOE-2 NHnneXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4W2NGlEPTB;NEW2MlcyOSEQvF2= M1rNV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
MC116 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTR3OD6xNVYh|ryP M1L6fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
RCC10RGB MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\TPWtNUUN3ME20OlAvODB3IN88US=> NUjrephzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
RL95-2 M2jxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPjPWd2UUN3ME20OlAvOjN5IN88US=> NFTtRnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzPTRzMkmvK|5USU6JRWK8M4E,
Raji M4XIWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf3XVRKSzVyPUS2PE4yPDNizszN M2XDclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
CAS-1 NF7XfYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ThRmlEPTB;NEeyMlA4OyEQvF2= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
Calu-6 Ml7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHuTWM2OD12N{WuNlY2KM7:TR?= M1LSUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFI2PDF{OT:nQnNCVkeHUkyvZV4>
KG-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTR5OD60OEDPxE1? NWT3cpo{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjV2MUK5M{c,W0GQR1XSQE9iRg>?
LB771-HNC M2jjSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M121cmlEPTB;NEiyMlI{OiEQvF2= MlLCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
ACN M1vjSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:yRoxKUUN3ME20PVMvPTl7IN88US=> MmLSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlU1OTJ7Lze+V2FPT0WUPD;hQi=>
KM12 NIDLW2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmS5TWM2OD12OU[uOVg6KM7:TR?= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyOVQyOjlxJ{7TRW5ITVJ:L3G+
U2OS NFvwfFNHfW6ldHnvckBie3OjeR?= M2TCOWJqdmSrbnegZYZncW6rdImgeI8hf2muZDD0fZBmKFOvbzDlfJBz\XO|ZXSgbY4hXTKRUzDj[YxteyCkeTDzZ4lvfGmubHH0bY9vKGOxdX70bY5oNCCNZDC9JFAvODF{NDFOwG0v MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB4M{WyNkc,OjNyNkO1NlI9N2F-
U2OS NYG4UFdjTnWwY4Tpc44h[XO|YYm= MWOyJIhzew>? MVPEbZNxdGGlZX3lcpQhd2ZiW{PIYYN6[2yxcHHtbY5mKG[{b32ge4lt\CC2eYDlJHNudyCneIDy[ZN{\WRiaX6gWVJQWyClZXzsd{Bi\nSncjCyJIhzeyCkeTDzZ4lvfGmubHH0bY9vKGOxdX70bY5oNCCNaTC9JFAvODF{NzFOwG0v NIL2bmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C2N|UzOid-MkOwOlM2OjJ:L3G+
TM3 M2C2SGZ2dmO2aX;uJIF{e2G7 MX[0PEBpenN? MWLJcohq[mm2aX;uJI9nKEinZHflbI9oKHOrZ37hcIlv\yCyYYToe4F6KGmwIH3veZNmKFSPMzDj[YxteyCkZXHybY5oKHCWQT24fGdtcS2OdXOgdoVxd3K2ZYKgZ49ve3S{dXP0JIF{e2W|c3XkJIF{KHS{YX7zZ5JqeHSrb37hcEBud2S3bHH0bY9vKG:oIFfsbUBi\nSncjC0PEBpenNiYomgcJVkcW[ncnHz[UBie3OjeTygTWM2OCB;IECuNFQ3KM7:TT6= MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB7MUW1PUc,OTlyOUG1OVk9N2F-
HCC827 NUHYfGp5TnWwY4Tpc44h[XO|YYm= M4XZZ2Rqe3CuYXPlcYVvfCCxZjDbN2heNWO7Y3zvdIFucW6nIH\yc40hW02RIG[0NFROKG23dHHueEBqdiCpZX\peIlvcWJicnXzbZN1[W62IHj1cYFvKEiFQ{iyO{Bk\WyuczDifUB{[2mwdHnscIF1cW:wIHPveY51cW6pLDDLbUA:KDBwMEWxJO69VS5? M2n5RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{i3NVU3Lz5{OEe4O|E2PjxxYU6=
HEK293 NGD4eYtHfW6ldHnvckBie3OjeR?= NEDQUYUzKGi{cx?= NXPlPFM3TGm|cHzhZ4Vu\W62IH;mJGJQTEmSWT3sZYJmdGynZDDjfYNtd3CjbXnu[UBnem:vIHj1cYFvKFOvbzDy[YNmeHSxcjDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IHHmeIVzKDJiaILzJIJ6KG[udX;y[ZNk\W6lZTDtbYNzd3Olb4D5MEBKSzVyIE2gNE4xPjRizszNMi=> MnvUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{Nki1OVEoRjJ{Mk[4OVUyRC:jPh?=
Shh Light2 MmjSSpVv[3Srb36gZZN{[Xl? M4HJRVMxKGi{cx?= NFPUVpJKdmirYnn0bY9vKG:oIHjl[IdmcG:pIIPp[45idGmwZzDwZZRpf2G7IHnuJI1wfXOnIGPobEBNcWeqdEKgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC|b37pZ{Bp\WSpZXjv[{1qdmS3Y3XkJGdNUTFvbXXkbYF1\WRidILhcpNkemmydHnvcoFtKGGldHn2bZR6KG2nYYP1doVlKGGodHXyJFMxKGi{czDifUBlfWGuIHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3MDC9JFAvODd2MTFOwG0v NFH0cWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{W2O|M4OSd-Mke1Olc{PzF:L3G+
U2OS NXz3coFlTnWwY4Tpc44h[XO|YYm= MVrCbY5lcW6pIHHm[olvcXS7IITvJHNudyCGNEezTEBufXSjboSg[ZhxemW|c3XkJIlvKFV{T2OgZ4VtdHNiYomgd4NqdnSrbHzheIlwdiClb4XueIlv\yxiS3SgQUAxNjFzNjFOwG0v MkixQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyNkO1NlIoRjJ|ME[zOVIzRC:jPh?=
DaOY NVHBR5ZVTnWwY4Tpc44h[XO|YYm= NVf1WZVFPDhiaILz Mn7UTY5pcWKrdHnvckBw\iCKZXTn[Yhw\yC|aXfuZYxqdmdiaX6gbJVu[W5iRHHPXUBk\WyuczDhd5Nme3OnZDDhd{Bld3ewcnXneYxifGmxbjDv[kBIdGlzIH3SUmEh\XiycnXzd4lwdiCjZoTldkA1QCCqcoOgZpkhWlRvUFPSJIFv[Wy7c3nzMEBKSzVyIE2gNE4yPiEQvF2u MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyMEexOkc,OjR7MEC3NVY9N2F-
U2OS NWTOO|RvTnWwY4Tpc44h[XO|YYm= NWjJVY11OiCqcoO= MnS1SIl{eGyjY3Xt[Y51KG:oIGuzTH1kgWOub4DhcYlv\SCocn;tJHNudyCGNEezTEBufXSjboSg[ZhxemW|c3XkJIlvKFV{T2OgZ4VtdHNiYX\0[ZIhOiCqcoOgZpkhe2OrboTpcIxifGmxbjDjc5VvfGmwZzygT4khRSByLkKzNkDPxE1w MlLMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyNkO1NlIoRjJ|ME[zOVIzRC:jPh?=
CHO MoW2SpVv[3Srb36gZZN{[Xl? M3n2PWFvfGGpb37pd5Qh[WO2aY\peJkh[XRiaIXtZY4hW22xIILlZ4VxfG:{IHX4dJJme3OnZDDpckBEUE9iY3XscJMh[nliW{PIYWhpNUGpIHLpcoRqdmdiYYPzZZktKEmFNUCgQUAxNjJ6IN88UU4> M{nQXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEmxOVU6Lz5zOUC5NVU2QTxxYU6=
Shh Light2 MXnGeY5kfGmxbjDhd5NigQ>? MlvqOFAhcHK| NGq2Z4tKdmirYnn0bY9vKG:oIGPITEBx[XSqd3H5JIlvKG2xdYPlJHNpcCCOaXfoeFIh[2WubIOgZYZ1\XJiNECgbJJ{KGK7IFfsbU1l\XCnbnTlcpQhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDJR|UxKD1iMD6zJO69VS5? M1jNR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUmyO|g5Lz5{MUW5Nlc5QDxxYU6=
Shh-light2 NGm4OIFHfW6ldHnvckBie3OjeR?= M4Xz[2lvcGmkaYTpc44hd2ZiU33vMY1m\GmjdHXkJGhpKHOrZ37hcIlv\yCrbjDoeY1idiCVaHitcIlocHR{IHPlcIx{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3MDC9JFAvOyEQvF2u NET1bm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK2PFU2OSd-MkKyOlg2PTF:L3G+
M210B4 MVzGeY5kfGmxbjDhd5NigQ>? MV2yOEBpenN? MUXJcohq[mm2aX;uJI9nKEinZHflbI9oKHOrZ37hcIlv\yCrbjDtc5V{\SCPMkGwRlQh[2WubIOgZZN{\XO|ZXSgZZMh\G:5boLl[5Vt[XSrb36gc4YhWHSlaDDtVm5CKGW6cILld5Nqd25iYX\0[ZIhOjRiaILzJIJ6KFKWLWDDVkBidmGueYPpd{whUUN3MDC9JFAvPDNizszNMi=> MlXEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MEC3NVYoRjJ2OUCwO|E3RC:jPh?=
Shh-Light 2 M2nEW2Z2dmO2aX;uJIF{e2G7 NX;zVXdSOiCmYYnz MmjURY51[WexbnnzeEBi[3Srdnn0fUBifCCVbX:gbY4hdW:3c3WgV4hpNUyrZ3j0JFIh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDTbIgucW6mdXPl[EBIdGlzLYLldI9zfGW{IHHjeIl3cXS7IHHmeIVzKDJiZHH5d{BjgSCmdXHsMYx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDt[ZRpd2RuIFnDOVAhRSByLkS4OEDPxE1w MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB4M{WyNkc,OjNyNkO1NlI9N2F-
Shh Light2 MVfGeY5kfGmxbjDhd5NigQ>? Mlz3TY5pcWKrdHnvckBw\iCVSFigbY4hdW:3c3WgV4hpKEyrZ3j0NkBk\WyuczDifUBIVElvcnXzdI9ve2m4ZTDmbZJm\my7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3MDC9JFAvPSEQvF2u NGrGdWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwPVA5OCd-MUmzNFkxQDB:L3G+
C3H10T1/2 MnrkSpVv[3Srb36gZZN{[Xl? NUiwUXhNUW6qaXLpeIlwdiCxZjDOMZRmem2rbnHsJHNJUCCjY4TpeoF1\WRicHH0bJdigSCrbjDtc5V{\SCFM1ixNHQyNzJiY3XscJMh[XO|ZYPz[YQh[XNiU1HHMYlv\HWlZXSgZ4VtdCCmaX\m[ZJmdnSrYYTpc44h[nliYXzrZYxqdmVicHjvd5Bp[XSjc3WgZZN{[XluIFnDOVAhRSByLk[g{txONg>? MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV7Mke4PEc,OjF3OUK3PFg9N2F-
C3H10T1/2 MnHHSpVv[3Srb36gZZN{[Xl? Mmm2OkBpenN? NGHOOopKdmirYnn0bY9vKG:oIGPBS{1qdmS3Y3XkJIRq\m[ncnXueIlifGmxbjDv[kBud3W|ZTDt[ZNmdmOqeX3hcEBxdHW{aYDveIVvfCCFM1ixNHQyNzJiY3XscJMhfG9iYXzrZYxqdmVicHjvd5Bp[XSjc3WgdI9{cXSrdnWgc4V{\W:kbHHzeJMh[W[2ZYKgOkBpenNuIFnDOVAhRSByLk[yJO69VS5? NFPQRnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK2PFU2OSd-MkKyOlg2PTF:L3G+
ASZ001 Mk[wSpVv[3Srb36gZZN{[Xl? NV;hR|hCPDhiaILz M4G5fmlvcGmkaYTpc44hd2ZiSHXk[4Vpd2dic3nncoFtcW6pIHnuJI1wfXOnIFHTXlAxOSClZXzsd{Bie3Onc4Pl[EBieyCmb4fudoVofWyjdHnvckBw\iCJbHmxJI1TVkFiZYjwdoV{e2mxbjDh[pRmeiB2ODDodpMh[nliUmStVGNTKGGwYXz5d4l{NCCLQ{WwJF0hOC54NjFOwG0v NXjXTYRqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFA4OTZpPkK0PVAxPzF4PD;hQi=>
M210B4 M4TKdWZ2dmO2aX;uJIF{e2G7 MXmyOEBpenN? NE\LUppKdmirYnn0bY9vKG:oIFjl[IdmcG:pIIPp[45idGmwZzDpckBud3W|ZTDNNlExSjRiY3XscJMh[XO|ZYPz[YQh[XNiZH;3cpJm\3WuYYTpc44hd2ZiR3zpNUBuWk6DIHX4dJJme3Orb36gZYZ1\XJiMkSgbJJ{KGK7IGLUMXBEWiCjbnHsfZNqeyxiSVO1NEA:KDBwODFOwG0v MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyMEexOkc,OjR7MEC3NVY9N2F-
medulloblastoma cells MWfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M{ize2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2VibXXkeYxtd2KuYYP0c41iKGOnbHzzJIhiemKxcnnu[{Bp\XSncn;6fYdwfXNicITjbFEh\2WwZTDifUBOXFRiYYPzZZktKEWFNUCgQUAyKM7:TT6= MlrKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MUe2N|EoRjF5NEG3OlMyRC:jPh?=
CHO MYPGeY5kfGmxbjDhd5NigQ>? NVfNc5BkSW62YXfvcol{fCCjY4Tpeol1gSCjdDDtc5V{\SCVbX:gdoVk\XC2b4Kg[ZhxemW|c3XkJIlvKEOKTzDj[YxteyCkeTDbN2heUGhvQXegZolv\GmwZzDhd5NigSxiSVO1NEA:KDFwMjFOwG0v MmrkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyOUG1OVkoRjF7MEmxOVU6RC:jPh?=
Shh-Light2 MnnnSpVv[3Srb36gZZN{[Xl? NWXoZZhvPDhiaILz NXzub4tFUW6qaXLpeIlwdiCxZjDTTGghcW5ibX;1d4UhW2iqLVzp[4h1OiClZXzsd{Bi\nSncjC0PEBpenNiYomgS4xqOSC{ZYDvdpRmeiCpZX7lJIF{e2G7IHnuJJBz\XOnbnPlJI9nKFODRzygTWM2OCB;IEGuN|EzKM7:TT6= NH;sc|g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUW0NVQ6OCd-MUm1OFE1QTB:L3G+
MEF Mn;iSpVv[3Srb36gZZN{[Xl? MYPJcohq[mm2aX;uJI9nKFOvbzDpckBud3W|ZTDQeINpNWSnZnnjbYVvfCCPRV[gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCVaHitbY5lfWOnZDDHcIkyKHS{YX7zZ5JqeHSrb37hcEBi[3Srdnn0fUwhUUN3MDC9JFEvPSEQvF2u NUDiSGpSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwO|Q2PDFpPkKzNFc1PTRzPD;hQi=>
MEF NVfQVW91TnWwY4Tpc44h[XO|YYm= MYWzNEBpenN? NIX0XVVKdmirYnn0bY9vKG:oIGPtc{BqdiCvb4Xz[UBRfGOqLXTl[olkcWWwdDDNSWYh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDTbIgucW6mdXPl[EBIdGlvcnXzdI9ve2m4ZTDi[ZRi\2GuYXP0c5Nq\GG|ZTDhZ5Rqfmm2eTDh[pRmeiB|MDDodpMh[nliQnX0ZWdNdyCjc4PhfUwhUUN3MDC9JFEvQSEQvF2u M1XhSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEe0OVQyLz5{M{C3OFU1OTxxYU6=
neural precursor cells NFu5TZNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1vIR2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2VibnX1doFtKHC{ZXP1dpNweiClZXzsd{BjgSClb3zvcpkh\m:{bXH0bY9vKGG|c3H5MEBGSzVyIE2gNVMvPDRizszNMi=> Mnr5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MUe2N|EoRjF5NEG3OlMyRC:jPh?=
U87 NIfsR3JEgXSxdH;4bYNqfHliYYPzZZk> MkPoR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVg4KGOnbHzzJIF{e2W|c3XkJIF{KH[rYXLpcIl1gSCrbjDwdoV{\W6lZTDv[kBj\XSjIHfseYN2em:waXThd4UtKEmFNUCgQUAyPS53IN88UU4> NETncWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGxOlkxPCd-MkCxNVY6ODR:L3G+
U87MG M2rjcmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NF7GO5U4OiCqcoO= MXPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV6N13HJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGOgZZN{[XluIFnDOVAhRSB{Mj61JO69VS5? NHLabFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyOlY2Pyd-MkKyNlY3PTd:L3G+
A549 NGXFfJpCdnSrY3HuZ4VzKGG|c3H5 NIjKW|RCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{BjgSCPVGOgZZN{[XluIFnDOVAhRSB2OTFOwG0v NWTnV2M2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiyNlE5PzJpPkG4NlIyQDd{PD;hQi=>
DU145 MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUjJeINsPSC3TR?= M{XyR|k3KGi{cx?= NXvTSlRVT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hTFVzNEWgZ4VtdHNiYYSgOUB2VSCjZoTldkA6PiCqcoO= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ2OUGyOUc,OTh{NEmxNlU9N2F-
DU145 MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlHqNVAhfU1? M3nFZlk3KGi{cx?= NXWzdodlT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hTFVzNEWgZ4VtdHNiYYSgNVAhfU1iYX\0[ZIhQTZiaILz MmfNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh{NEmxNlUoRjF6MkS5NVI2RC:jPh?=
HEK293 NGPPeGNHfW6ldHnvckBie3OjeR?= NVfYVW84UW6qaXLpeIlwdiCxZjDi[ZRiKGejbHHjeI9{cWSjc3WgbY4hUEWNMkmzJINmdGy| NILoSWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S5OFc3Pid-MUe0PVQ4PjZ:L3G+
22Rv MmPiSpVv[3Srb36gZZN{[Xl? MkW1VoVlfWO2aX;uJI9nKGW6cILld5Nqd25ib3[gVHREUCCvUl7BJIlvKGi3bXHuJFIzWnZiY3XscJM> M1Tqb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEm0O|Y3Lz5zN{S5OFc3PjxxYU6=
PANC1 NF\Ic|JHfW6ldHnvckBie3OjeR?= NHPZ[GQxNjJidV2= M{\yelI1KGi{cx?= MYfJcohq[mm2aX;uJI9nKEiqL1fMTVEudWWmaXH0[YQhWFSFSDDtVm5CKGW6cILld5Nqd25iaX6gbJVu[W5iUFHOR|Eh[2WubIOgZZQhOC5{IIXNJIFnfGW{IEK0JIhzeyCkeTDSWE1RS1J? M2nTclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNEWwNVcxLz5{MES1NFE4ODxxYU6=
PANC1 NVX3b2g4TnWwY4Tpc44h[XO|YYm= MUSwMlQhfU1? NFiyT4czPCCqcoO= NWnMSoRYUW6qaXLpeIlwdiCxZjDIbE9IVElzLX3l[IlifGWmIGDUR2ghdVKQQTDlfJBz\XO|aX;uJIlvKGi3bXHuJHBCVkNzIHPlcIx{KGG2IECuOEB2VSCjZoTldkAzPCCqcoOgZpkhWlRvUFPS NE[3SIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MES1NFE4OCd-MkC0OVAyPzB:L3G+
Shh Light2 NUD2[Wd2TnWwY4Tpc44h[XO|YYm= NHvnSJc3NjJ3IIXN Mki0N|AhcHK| MX\Jcohq[mm2aX;uJI9nKE5vcHHscYl1d3muYYTl[EBUcGhiaX6gcY92e2ViU3joJGxq\2i2MjDj[YxteyCjdDC2MlI2KHWPIHHmeIVzKDNyIHjyd{BjgSCoaYLl[ox6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeR?= M{TwOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MUWxO|MyLz5zOUG1NVc{OTxxYU6=
U87MG MorCSpVv[3Srb36gZZN{[Xl? M{TzNVExKHWP NYjPbWFPPCCqcoO= MX;Jcohq[mm2aX;uJI9nKEinZHflbI9oKHOrZ37hcIlv\yCyYYToe4F6KGmwIHj1cYFvKFV6N13HJINmdGy|IHHzd4V{e2WmIHHzJIRwf25icnXneYxifGmxbjDv[kBIdGlzIHH0JFExKHWPIHHmeIVzKDRiaILzJIJ6KFKWLWDDVkBidmGueYPpdy=> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ{Nk[1O{c,OjJ{Mk[2OVc9N2F-
HEK293 NED4bVNHfW6ldHnvckBie3OjeR?= M4H0dFUhfU1? MnPCNVAhcHK| M1v0TGRqe3CuYXPlcYVvfCCxZjDCU2RKWFlvY4njcI9x[W2rbnWg[pJwdSCqdX3hckBUdW9iZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjdDC1JJVOKG2nYYP1doVlKGGodHXyJFExKGi{czDifUBFSVCLIIP0ZYlvcW6pIHLhd4VlKG[udX;y[ZNk\W6lZTDtbYNzd3Olb4DpZ{Bie3OjeR?= MnzmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5M{[wOlMoRjJ5N{O2NFY{RC:jPh?=
HEK293 NIX5[YtHfW6ldHnvckBie3OjeR?= M3PJNVUhfU1? MXKxNEBpenN? NWT4dVBzTGm|cHzhZ4Vu\W62IH;mJGJQTEmSWT3jfYNtd3CjbXnu[UBnem:vIHj1cYFvKFOvbzDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IHH0JFUhfU1ibXXhd5Vz\WRiYX\0[ZIhOTBiaILzJIJ6KE[DQ2OgZY5idHm|aYO= NYHkNFdMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3N|YxPjNpPkK3O|M3ODZ|PD;hQi=>
C3H10T1/2 MUDGeY5kfGmxbjDhd5NigQ>? Mn\3OVUvPSC2bzC0OVAxKG6P NYnxVnM{S2:vcHX0bZRqfmViaX7obYJqfGmxbjDv[kBUdW9iaX6gcY92e2ViQ{PINVBVOS9{IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhW0GJLXnu[JVk\WRiR3zpNUB1emGwc3PybZB1cW:wYXygZYN1cX[rdImgZZQhPTVwNTD0c{A1PTByIH7NJIJ6KHGSQ2KgZY5idHm|aYO= M{PSN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEe0OVQyLz5{M{C3OFU1OTxxYU6=
U2OS NWHp[ph[TnWwY4Tpc44h[XO|YYm= MVe1JJVO MlfjOkBpenN? NWSxeYl7SW62YXfvcol{fCCjY4Tpeol1gSCjdDDjbIlu\XKrYzDTcY8hPjN|IH31eIFvfCCneIDy[ZN{\WRiaX6gWVJQWyClZXzsd{Bkd2W6cILld5NqdmdiYnX0ZUBienKnc4TpclIuT0[SIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiaX70doFk\WyudXzhdkBj\XSjIHHydoV{fGmwMj3HSnAh[WepcnXnZZRmKG[xcn3heIlwdiCjdDC1JJVOKGGodHXyJFYhcHK|IHL5JINwdm[xY3HsJI1q[3Kxc3PvdJk> M{LMO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|ME[zOVIzLz5{M{C2N|UzOjxxYU6=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Snail / E-cadherin / Slug / Vimentin ; 

PubMed: 26859575     


SW1736 and WRO82 cells were incubated in the presence of vehicle (0.5% DMSO) or the indicated concentrations of cyclopamine or GANT61 for 72 hr. The cells were harvested and analyzed for the expression of several genes involved in EMT.

Gli1 / TGF-β1 / CXCR4; 

PubMed: 26137001     


Western blotting demonstrated that Gli1, TGF-β1 and CXCR4 protein expression levels were downregulated in the AGS cells treated with cyclopamine for 24 h.

NF-κB / Cyclin D1 / MMP2 / MMP9; 

PubMed: 23599805     


Whole cell lysates were prepared, and 50 μg proteins were resolved using SDS-PAGE, followed by immunoblotting with the indicated specific antibodies against NF-κB, cyclin D1, MMP2 and MMP9. 

26859575 26137001 23599805
Immunofluorescence
PCNA / β-catenin; 

PubMed: 28747625     


Immunofluorescence images demonstrating the distribution of PCNA or β-catenin in EH cells pre-treated with cyclopamine in presence and absence of estrogen for 24 h. Experiments were repeated at least three times.

Vimentin; 

PubMed: 24553082     


Vimentin protein expression was reduced following treatment with cyclopamine (20 μmol/L; 72 h), detected by immunocytochemistry.

28747625 24553082
体内研究 Cyclopamine 每天按50 mg/kg剂量处理小鼠,持续22天,消除HUCCT1移植瘤,且没有明显副作用。[2] Cyclopamine 按1.2 mg剂量处理Panc 05.04和 L3.6sl驱动的肿瘤7天,前者诱导明显的肿瘤细胞凋亡,后者降低肿瘤质量,降低达50-60%,但是作用于BxPC3-SMOlow肿瘤没有效果。[3] Cyclopamine单独处理E3LZ10.7 和L3.6pl移植瘤,显著抑制肿瘤转移,且和 Gemcitabine联用处理,完全废除转移。[4]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
- 合并

激酶实验:

Gli-Luc实验测定Hh 信号通路末期, 即使用荧光素酶进行读数,测定Gli的转录调控。Cyclopamine 在DMSO中连续稀释用于实验,然后加到空的实验板上。TM3Hh12 细胞(TM3 细胞含Hh反应受体基因结构 pTA-8xGli-Luc) 悬浮在含5% FBS 和15 mM Hepes pH 7.3的F12 Ham’s/DMEM (1:1)培养基上, 加到实验板上,与Cyclopamine在37oC下温育30分钟左右。1 nM Hh-Ag 1.5 加到实验板上,然后在37oC下温育。48小时后,在实验板中加入Bright-Glo或MTS,然后在492 nm处测定发光度或吸光度。通过分析反应曲线,使用R统计软件包测定IC50值。
细胞实验:[2]
- 合并
  • Cell lines: SEG1, OE33, KYAE, KYSE180, SNU1, AGS, SNU16, NCI-N-87, HUCCT1, PANC1, PL5, PL6, BXPC3, HS766T, KYSE150, GBD1, DLD1, 和HCT116
  • Concentrations: 溶于DMSO, 终浓度为3 μM
  • Incubation Time: 4天
  • Method: 在96孔板上,用Cyclopamine 处理细胞。通过MTS实验测定细胞活力。进行CellTiter96比色测定,进行2和4天,然后在490 nm处通过测定光密度而测定存活细胞。
    (Only for Reference)
动物实验:[2]
- 合并
  • Animal Models: 皮下注射HUCCT1细胞的无胸腺裸鼠
  • Dosages: 50 mg/kg/day
  • Administration: 皮下注射处理
    (Only for Reference)

溶解度 (25°C)

体外 DMF 10 mg/mL warmed (24.29 mM)
Ethanol 2 mg/mL warmed (4.85 mM)
DMSO Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 411.62
化学式

C27H41NO2

CAS号 4449-51-8
储存条件 粉状
溶于溶剂
别名 11-deoxojervine

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    How to reconstitute the compound for in vivo use in mice?

  • 回答:

    One paper dissolved this drug in DMSO, and diluted in saline: Berman DM, et al. Nature, 2003, 425(6960), 846-851. Alternatively, you can try this vehicle: 10% DMSO+30% PEG 300+5% Tween 80+ddH2O for P.O. When preparing the solution, please dissolve the compound in DMSO clearly first. Then add PEG300 and Tween, after they mixed well, dilute with water.

Hedgehog/Smoothened Signaling Pathway Map

Hedgehog/Smoothened Inhibitors with Unique Features

相关Hedgehog/Smoothened产品

Tags: 购买Cyclopamine | Cyclopamine供应商 | 采购Cyclopamine | Cyclopamine价格 | Cyclopamine生产 | 订购Cyclopamine | Cyclopamine代理商
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID