SAG (Smoothened Agonist)

SAG (Smoothened Agonist)是 Smoothened (Smo) 的有效激动剂。Smoothened Agonist 在 Shh-LIGHT2 细胞中诱导萤火虫荧光素酶表达,EC50 为 3 nM。

SAG (Smoothened Agonist) Chemical Structure

SAG (Smoothened Agonist) Chemical Structure

CAS: 912545-86-9

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 1203.93 现货
5mg RMB 975.17 现货
25mg RMB 2924.76 现货
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产品质控

批次: 纯度: 99.94%
99.93

SAG (Smoothened Agonist)相关产品

Hedgehog/Smoothened抑制剂选择性比较

生物活性

产品描述 SAG (Smoothened Agonist)是 Smoothened (Smo) 的有效激动剂。Smoothened Agonist 在 Shh-LIGHT2 细胞中诱导萤火虫荧光素酶表达,EC50 为 3 nM。
靶点
Smo [1]
(in Shh-LIGHT2 cells)
3 nM(EC50)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05937178 Recruiting
Hepatitis B Chronic
Huashan Hospital|The First Affiliated Hospital of Anhui Medical University|Anhui Provincial Hospital|Beijing YouAn Hospital|Peking University People''s Hospital|Peking University First Hospital|Xiamen Hospital of Traditional Chinese Medicine|First Affiliated Hospital of Fujian Medical University|LanZhou University|Third Affiliated Hospital Sun Yat-Sen University|First Affiliated Hospital of Guangxi Medical University|The Affiliated Hospital Of Guizhou Medical University|Hainan General Hospital|Hebei Medical University Third Hospital|The First Affiliated Hospital of Henan University of Traditional Chinese Medicine|Henan Provincial People''s Hospital|The Second Affiliated Hospital of Harbin Medical University|Tongji Hospital|Wuhan Union Hospital China|Renmin Hospital of Wuhan University|Central South University|Xiangya Hospital of Central South University|The First Hospital of Jilin University|the Second Hospital of Nangjing|The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School|The First Affiliated Hospital with Nanjing Medical University|The Affiliated Hospital of Xuzhou Medical University|The First Affiliated Hospital of Nanchang University|Shengjing Hospital|Qingdao Sixth People''s Hospital|Shandong Provincial Hospital|The Second Hospital of Shandong University|The First Affiliated Hospital of Shanxi Medical University|Tang-Du Hospital|First Affiliated Hospital Xi''an Jiaotong University|Ruijin Hospital|West China Hospital|Tianjin Second People''s Hospital|First Affiliated Hospital of Xinjiang Medical University|The First People''s Hospital of Yunnan|Shulan (Hangzhou) Hospital|Zhejiang University|Southwest Hospital China|The Second Affiliated Hospital of Chongqing Medical University|Sichuan Provincial People''s Hospital
January 31 2023 --
NCT05701592 Recruiting
Posterior Cruciate Ligament Tear
Konrad Malinowski MD|Artromedical Konrad Malinowski Clinic
December 20 2022 --
NCT03645044 Active not recruiting
Hiv|HBV Coinfection
University of Melbourne|National Health and Medical Research Council Australia|The University of Western Australia|University of Adelaide|The HIV Netherlands Australia Thailand Research Collaboration|University of Malaya|YR Gaitonde Centre for AIDS Research and Education|Melbourne Health
May 24 2018 --

化学信息&溶解度

分子量 490.06 分子式

C28H28ClN3OS

CAS号 912545-86-9 SDF --
Smiles CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(Cl)C5=CC=CC=C5S4
储存条件(自收到货起) 3年 -20°C 粉状

体外溶解度
批次:

DMSO : 98 mg/mL ( 199.97 mM; DMSO吸湿会降低化合物溶解度,请使用新开封DMSO)

Ethanol : 98 mg/mL

Water : Insoluble

摩尔浓度计算器

体内溶解度
批次:

现配现用,请按从左到右的顺序依次添加,澄清后再加入下一溶剂

动物体内配方计算器

实验计算

摩尔浓度计算器

质量 浓度 体积 分子量

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

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