Temozolomide (CCRG 81045)

For research use only. Not for use in humans.

目录号:S1237 别名: NSC 362856,TMZ 中文名称:蒂清,替莫唑胺

Temozolomide (CCRG 81045) Chemical Structure

CAS No. 85622-93-1

Temozolomide (CCRG81045, NSC 362856, TMZ)是一种单功能的SN-1烷化剂,修饰DNA环上的氮原子以及环外氧基团。在生理pH值下,TMZ转化为活性产物MTIC、降解为methyldiazonium cation,后者再将甲基转移到DNA, 阻碍DNA复制启动,诱使细胞凋亡,是一种DNA损伤诱导剂。Temozolomide可诱导凋亡并具有抗肿瘤的活性。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 647.01 现货
RMB 574.37 现货
RMB 1411.95 现货
RMB 7125.3 现货
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客户使用Selleck生产的Temozolomide (CCRG 81045)发表文献121篇:

产品安全说明书

DNA/RNA Synthesis抑制剂选择性比较

生物活性

产品描述 Temozolomide (CCRG81045, NSC 362856, TMZ)是一种单功能的SN-1烷化剂,修饰DNA环上的氮原子以及环外氧基团。在生理pH值下,TMZ转化为活性产物MTIC、降解为methyldiazonium cation,后者再将甲基转移到DNA, 阻碍DNA复制启动,诱使细胞凋亡,是一种DNA损伤诱导剂。Temozolomide可诱导凋亡并具有抗肿瘤的活性。
特性 Methazolastone是第二代烷化剂。
靶点
DNA replication [1]
(L-1210, L-1210/BCNU cells)
体外研究

Methazolastone引起DNA碱不稳定位点的形成,其在L-1210和L-1210/BCNU细胞系中以相似数量存在,并且以相似比率修复。在L-1210中,methazolastone诱导细胞阻滞在SL-G2-M期,但在L-1210/BCNU中无此作用。[1]对化疗敏感与耐受的细胞(D54-R 和 U87-R)对Methazolastone的敏感性在高氧情况下被显著增强。Methazolastone和高氧均与ERK p44/42 MAPK (Erk1/2)磷酸化的增加相关,但是在D54-R细胞中增加程度较低,表明Erk1/2可能参与高氧与Methazolastone介导的细胞死亡的调节。高氧增强Methazolastone诱导细胞凋亡在GBM细胞中产生的细胞毒性,可能是通过MAPK相关的途径发挥作用。[2] Methazolastone诱导单核细胞中DNA损伤应答通路ATM-Chk2 和ATR-Chk1,导致p53活化。[3]长期Methazolastone暴露导致获得性Methazolastone耐药,并提高miR-21表达。[4] Methazolastone治疗引起内质网(ER)应激,增加GADD153和GRP78蛋白质表达,并减少caspase 12前体蛋白质。Methazolastone通过线粒体损伤和内质网应激依赖机制诱导自吞噬,以保护神经胶质瘤细胞。[5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Kelly MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[zbVR2PDhiaB?= Ml\FTWM2OD1zM{muNlDjiIoEsfMAjVUvQTVizszN NYnOdo1mRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5OlAzQDJpPkK1PVYxOjh{PD;hQi=>
KellyCis83 NXj1RWE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\RboxJPDhiaB?= NXjVdmpnUUN3ME2yOVEvODEkgJpCtgKBkTF3Lke1JO69VQ>? M2XYSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OU[wNlgzLz5{NUm2NFI5OjxxYU6=
SK-N-AS NXq1VpZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LBO|Q5KGh? M1GxT2lEPTB;MkK3Mlcx6oDLwsJihKkzOi5zNTFOwG0> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl4MEK4Nkc,OjV7NkCyPFI9N2F-
SK-N-ASCis24 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHOTmM1QCCq MmDpTWM2OD12OECuOlDjiIoEsfMAjVExOS5zNTFOwG0> NGfPWlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUm2NFI5Oid-MkW5OlAzQDJ:L3G+
CHP-212 MoTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;zVow5PDhiaB?= MoHOTWM2OD15Lkm35qCKyrIkgJmwMlY6KM7:TR?= NE\nVmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUm2NFI5Oid-MkW5OlAzQDJ:L3G+
CHP-212Cis100 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PJTVQ5KGh? M2rQOmlEPTB;OT61OgKBkcLz4pEJNE45QCEQvF2= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl4MEK4Nkc,OjV7NkCyPFI9N2F-
U87  MXfGeY5kfGmxbjDBd5NigQ>? M4nDb|ExOCEQvF2= Mly3NlQuPzJiaB?= M4n4b4lv\HWlZYOgSINTOSCneIDy[ZN{cW:w NEi1OFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUiwPFg3QCd-MkW4NFg5Pjh:L3G+
LN229 M4f3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIK1W3IxNTVyIN88US=> MUTJR|UxRTF4IN88US=> NG\XbmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe1NFI4Oyd-MkW3OVAzPzN:L3G+
TR-LN229 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWWwMVUxKM7:TR?= M{\pfmlEPTB;N{eg{txO NFTHRmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe1NFI4Oyd-MkW3OVAzPzN:L3G+
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A375 M{LuW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn63OFjDqGkEoB?= Mlz1TWM2OD1{NkWg{txO Mlf5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MkS1OVIoRjJ3NUK0OVUzRC:jPh?=
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M238 NFjYe3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTPOYZWPDkEoHlCpC=> MVnJR|UxRTRyIN88US=> NUfyTGxrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1NlQ2PTJpPkK1OVI1PTV{PD;hQi=>
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GBM 047T NYDq[JlmSW62aYT1cY9zKGG|c3H5 MkHINlAhfU1? NX7ZcpYzOSC2bzCyJJdm\Wu| M2C5PXR2dW:{aXPp[IFtKGWoZnXjeEBqdiCyYYTp[Y51KGSncnn2[YQhT0KPIEC0O3Qh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIH7leZJwe3CqZYLlJIZwem2jdHnvckBifCB{MDD1UUBi\nSncjCxJJRwKDJid3Xlb5Mh[nliM1SgeJVud3JiY3zvco9o\W6rYzDhd5NigQ>? MnPjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|NUW1N|IoRjJ4M{W1OVMzRC:jPh?=
GBM 464T M4HFO2FvfGm2dX3vdkBie3OjeR?= M1u5cFIxKHWP MWOxJJRwKDJid3Xlb5M> NEnke4hVfW2xcnnjbYRidCCnZn\lZ5QhcW5icHH0bYVvfCCmZYLpeoVlKEeETTC0OlRVKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDu[ZVzd3OyaHXy[UBnd3KvYYTpc44h[XRiMkCgeW0h[W[2ZYKgNUB1dyB{IIfl[Yt{KGK7IEPEJJR2dW:{IHPsc45w\2WwaXOgZZN{[Xl? NGfpeG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkO1OVU{Oid-Mk[zOVU2OzJ:L3G+
U87MG NWDLRVFSTnWwY4Tpc44h[XO|YYm= NIeyNFY{KGi{cx?= NUDye2JPUW6mdXP0bY9vKG:oIFTORUBidGu7bHH0bY9vKGmwIHj1cYFvKFV6N13HJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKE55LV3l[Gch\m:{bXH0bY9vKGGodHXyJFMhcHK|IHL5JGxENU2VL13TJIFv[Wy7c3nz NE\tXZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[xOFQyPCd-Mke2NVQ1OTR:L3G+
U87MG NWr0eJljSW62aYT1cY9zKGG|c3H5 MVPBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXOEfNS{Bk\WyuczDvdpRpd3SxcHnjZYxtgSC6ZX7v[5Ji\nSnZDDpckBJ[XKuYX6gcpVl\SCvb4Xz[UBjemGrbjDhd5Nme3OnZDDhd{BqdmS3Y4Tpc44hd2Zic3zve{B1fW2xcjDndo94fGhiYYSgOVAhfW2xbD;r[{whcXZiYXTtbY5qe3SncnXkJI9v[2ViZHHpcJkh\m:{IEWg[IF6ew>? MoTSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4MUS0NVQoRjJ5NkG0OFE1RC:jPh?=
U87MG MWjBcpRqfHWvb4KgZZN{[Xl? NETBdY1CdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVPFdOTyClZXzsd{BwenSqb4TvdIlk[WyueTD4[Y5w\3KjZoTl[EBqdiCKYYLsZY4hdnWmZTDtc5V{\SCkcnHpckBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDtc5V{\SC|dYL2bZZidCCjdDC1NEB2dW:uL3vnMEBqfiCjZH3pcol{fGW{ZXSgc45k\SCmYXnsfUBnd3JiNTDkZZl{ NHfO[4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[xOFQyPCd-Mke2NVQ1OTR:L3G+
MDCK MX3DfZRwfG:6aXPpeJkh[XO|YYm= Ml:wNlQhcHK| Mmm2R5l1d3SxeHnjbZR6KGGpYXnud5QhVUSFSzDj[YxteyCneIDy[ZN{cW6pIHPhdoJwdmmlIHHubJllemG|ZTC5JIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCrbnP1ZoF1\WRiZn;yJFI1KGi{czDt[YF{fXKnZDDh[pRmeiB5IHThfZMhfW6mZYKgco9zdW:6aXOgZ49v\Gm2aX;uJIJ6KG2ndHj5cIVv\SCkbIXlJJN1[WmwaX7nJIJie2WmIHPsc45w\2WwaXOgd5Vzfmm4YXygZZN{[Xl? MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzh{M{i3PUc,Ojd6MkO4O|k9N2F-
MDCK MknkR5l1d3SxeHnjbZR6KGG|c3H5 NFG1fFIzPCCqcoO= NGjDPWlEgXSxdH;4bYNqfHliYXfhbY5{fCCPRFPLJINmdGy|IHX4dJJme3OrbnegZ4Fz[m:waXOgZY5pgWS{YYPlJFkh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHnuZ5Vj[XSnZDDmc5IhOjRiaILzJI1m[XO3cnXkJIFnfGW{IEeg[IF6eyC3bnTldkBpgXCxeHnjJINwdmSrdHnvckBjgSCvZYTofYxmdmViYnz1[UB{fGGrbnnu[{Bj[XOnZDDjcI9vd2enbnnjJJN2en[rdnHsJIF{e2G7 NEXBWog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{iyN|g4QSd-Mke4NlM5Pzl:L3G+
NB-EBc1 Mn;rdWhVWyCjc4PhfS=> NHHVdW5yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTlKtSWJkOSClZXzsdy=> M3zlW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
C6 Mo\sR5l1d3SxeHnjbZR6KGG|c3H5 NXfvUXVRPCCmYYnz NH;5VnpGSzVyIE2gNVYvPSEQvF2= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4NVAwLz6FaFXNRmw9N2F-
U87 MnLIR5l1d3SxeHnjbZR6KGG|c3H5 NX;HTmFrPzJiaILz M2TUZ2lEPTBiPTCxPU4{QCEQvF2= MlOwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFExNyd-Q3jFUWJNRC:jPh?=
SNB19 MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MonNO{Bl[Xm| M3;t[2dKPTBiPTCzOU44KM7:TR?= NHO3e|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5OTBxJ{7DbGVOSkx:L3G+
SNB19 MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmHpO{Bl[Xm| NGDBUmhIUTVyIE2gOFUvPiEQvF2= MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4NVAwLz6FaFXNRmw9N2F-
U373 MW\GeY5kfGmxbjDhd5NigQ>? NYXwcJBQOTByIIXN NGDqUGw4OiCqcoO= M2TnN2lv\HWldHnvckBw\iCmb4XicIUhe3S{YX7k[YQhTE6DIHLy[YFsKGmwIHXtdJR6KH[nY4TvdkB1emGwc3\lZ5Rm\CCqdX3hckBWOzd|IHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIdidW2jLViyRXghdGW4ZXygZZQhOTByIIXNJIFnfGW{IEeyJIhzeyCkeTDmcI94KGO7dH;t[ZRzgQ>? MmnrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFExNyd-Q3jFUWJNRC:jPh?=
Glioma M4XlWmFvfGm2dX3vdkBie3OjeR?= M3vQN2FvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JGhwdW9ic3HwbYVveyBqaIXtZY4qKEeuaX;tZUBk\WyuczD4[Y5w\3KjZoTl[EBqdiC2cnHud4dmdmmlIH3veZNmKGG|c3Xzd4VlKGG|IH3veZNmKHO3co\peoFt MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4NVAwLz6FaFXNRmw9N2F-

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pERK / ERK / p-p38 / p38; 

PubMed: 24436439     


Cells were treated with TMZ (0.5 mM) time dependently, and Western blotting was used to analyze for phosphorylated ERK and p38 MAPK expression.

DR5 / c-FLIP / Survivin / XIAP; 

PubMed: 24436439     


Western blot analysis showing expressions in DR5 and antiapoptotic proteins (c-FLIP, survivin, and XIAP) in glioma cells treated with increasing doses of TMZ (0–2 mM) for 24 hours. 

24436439
Growth inhibition assay
Cell viability; 

PubMed: 25751281     


Distinct temozolomide-resistance for MGMT-expressing (SF767) and MGMT-negative (U87) GBM cells was assessed.

25751281
Immunofluorescence
Phalloidin / Phospho-H2A.X; 

PubMed: 27375225     


Immunofluorescence analysis of the level of phospho-H2A.X in nucleus which can reflect DNA damage response increased significantly at day 6, peaked during days 7-10 and decreased significantly at day 12 after treatment temozolomide (200 μM). 

cleaved caspase-3; 

PubMed: 25663820     


Representative Photomicrographs of cleaved caspase-3 immunoreactivity in control (DMSO treated) and treated group of U87 cells. Base line immunofluorescence was detected in control group. Significant Increase in immunofluorescence is detected in all treated groups with the highest observed intensity in combination treatment group (NA-2 + TMZ).

27375225 25663820
体内研究 每天腹腔注射40 mg/kg,连续5天(肿瘤移植后1-5天)后,在L-1210 和L-1210/BCNU中,methazolastone分别增加86%和22%的寿命。在L-1210/BCNU中,100 μM 或200 μM治疗后没有作用,仅400 μM methazolastone使细胞在有丝分裂前期产生积聚,但是在L-1210中效果较弱。在L-1210/BCNU中,SL-G2-M期细胞的最大积聚在48-72小时后,大约为30%,未处理的细胞为23%。患有L- 1210白血病的小鼠静脉注射methazolastone (40 mg/kg)时,也会使细胞在SL-G2-M期积聚。而给予相同剂量药物的小鼠L-1210/BCNU细胞中,没有此作用。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[1]

- 合并
  • Cell lines: L-1210 和 L-1210/BCNU 细胞
  • Concentrations: 0 μM -100 μM
  • Incubation Time: 1小时
  • Method:

    L-1210和L-1210/ BCNU细胞以0.2×104 cells/mL接种,并培养24小时。培养基用Methazolastone在37℃下处理1小时,然后用PBS洗涤两次,离心并重新悬浮在新鲜培养基中。对照组和处理试样在48小时时以1:4在新鲜培养基中稀释,第96小时时,以1:2稀释。整个实验中使用这些稀释的细胞浓度介于3×105和8×105/mL之间。该范围内对照组呈对数生长。


    (Only for Reference)
动物实验:

[1]

- 合并
  • Animal Models: 负荷L-1210 和 L-1210/BCNU细胞的DBA/2小鼠
  • Dosages: 40 mg/kg
  • Administration: 静脉注射给药
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 38 mg/mL (195.72 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+30% PEG 300+ddH2O
2mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 194.15
化学式

C6H6N6O2

CAS号 85622-93-1
储存条件 粉状
溶于溶剂
别名 NSC 362856,TMZ

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03796507 Withdrawn Drug: Temozolomide Glioma of Brain University of Rochester|National Institutes of Health (NIH) September 1 2021 Early Phase 1
NCT04901702 Recruiting Drug: Onivyde|Drug: Talazoparib|Drug: Temozolomide Recurrent Solid Tumor|Recurrent Ewing Sarcoma|Recurrent Hepatoblastoma|Recurrent Malignant Germ Cell Tumor|Recurrent Malignant Solid Neoplasm|Recurrent Neuroblastoma|Recurrent Osteosarcoma|Recurrent Peripheral Primitive Neuroectodermal Tumor|Recurrent Rhabdoid Tumor|Recurrent Rhabdomyosarcoma|Recurrent Soft Tissue Sarcoma|Recurrent Wilms Tumor|Refractory Ewing Sarcoma|Refractory Hepatoblastoma|Refractory Malignant Germ Cell Tumor|Refractory Malignant Solid Neoplasm|Refractory Neuroblastoma|Refractory Osteosarcoma|Refractory Peripheral Primitive Neuroectodermal Tumor|Refractory Rhabdoid Tumor|Refractory Rhabdomyosarcoma|Refractory Soft Tissue Sarcoma St. Jude Children''s Research Hospital|Pfizer|Ipsen June 9 2021 Phase 1|Phase 2
NCT04893785 Not yet recruiting Drug: Cabozantinib and Temozolomide Lung Neuroendocrine Neoplasm|GEP Neuroendocrine Tumor National Cancer Institute Naples June 2021 Phase 2
NCT04200066 Not yet recruiting Drug: Temozolomide Tamoxifen Maprotiline Glioblastoma|Brain Tumor University of Rochester May 1 2021 Phase 1
NCT04610736 Recruiting Drug: Temozolomide Oral Suspension Pediatric Cancer Orphelia Pharma|ClinSearch March 2021 Phase 1

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在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

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  • * 必填项

DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID