Perifosine (KRX-0401)

For research use only. Not for use in humans.

目录号:S1037 别名: NSC639966, D21266 中文名称:哌立福新

Perifosine (KRX-0401) Chemical Structure

CAS No. 157716-52-4

Perifosine (KRX-0401, NSC639966, D21266)是一种新型的Akt抑制剂,在MM.1S细胞中IC50为4.7 μM,靶向作用于Akt的pleckstrin同源结构域。Phase 3。

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客户使用Selleck生产的Perifosine (KRX-0401)发表文献156篇:

质量管理及产品安全说明书

Akt抑制剂选择性比较

生物活性

产品描述 Perifosine (KRX-0401, NSC639966, D21266)是一种新型的Akt抑制剂,在MM.1S细胞中IC50为4.7 μM,靶向作用于Akt的pleckstrin同源结构域。Phase 3。
靶点
Akt [1]
(MM.1S cells)
4.7 μM
体外研究

Perifosine抑制永生化角质形成细胞(HaCaT细胞)和头颈部鳞状癌细胞增值,IC50 为0.6-8.9 μM。[1] Perifosine极力减少Akt的磷酸化水平和细胞外信号调节激酶(ERK)1/2,诱导细胞周期停滞在G1和G2,并引起的小鼠的神经胶质祖细胞的剂量依赖性生长抑制。[2] Perifosine (10 μM) 完全抑制MM.1S细胞中Akt的磷酸化。[3] 最近的一项研究表明Perifosine通过阻断Akt的磷酸化诱导人类肝癌细胞中细胞周期停滞和细胞凋亡。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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MOLM NXfEOW1wSXCxcITvd4l{KEG|c4PhfS=> NGLEd2UyOMLizszN M4TMW|I1NzR6IHi= NVO0WHZFcW6mdXPld{BieG:ydH;zbZMhfGmvZT3k[ZBmdmSnboTsfS=> NG\XVHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGzNFk3OCd-MkCxN|A6PjB:L3G+
OCI M2P5fmFxd3C2b4Ppd{BCe3O|YYm= NVywUnRLOTEEoN88US=> NVqxcVZ2OjRxNEigbC=> MVnpcoR2[2W|IHHwc5B1d3OrczD0bY1mNWSncHXu[IVvfGy7 NX:0VIc3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxN|A6PjBpPkKwNVMxQTZyPD;hQi=>
BJAB M4rPVmFxd3C2b4Ppd{BCe3O|YYm= MnnpNVDDqM7:TR?= NYj5fmlKOjRxNEigbC=> M3TBSIlv\HWlZYOgZZBweHSxc3nzJJRqdWVvZHXw[Y5l\W62bIm= MkHLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzM{C5OlAoRjJyMUOwPVYxRC:jPh?=
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SKW6.4 MXnBdI9xfG:|aYOgRZN{e2G7 NHzRcpcyOMLizszN M{LwW|I1NzR6IHi= MULpcoR2[2W|IHHwc5B1d3OrczD0bY1mNWSncHXu[IVvfGy7 MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF|MEm2NEc,OjBzM{C5OlA9N2F-
HL-60 M{e1fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUiyMVExyqEQvF2= NFLIVIs1QMLiaB?= MmHvbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZI> MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF|MEm2NEc,OjBzM{C5OlA9N2F-
MOLM M2HYbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXmyMVExyqEQvF2= NYfJdFdXPDkEoHi= M3XDdolvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVz NIDDe3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGzNFk3OCd-MkCxN|A6PjB:L3G+
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MAVER NGjtWJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\GSFIuOTEEoN88US=> M{nq[|Q5yqCq NIXkXnVqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? NGHmbZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGzNFk3OCd-MkCxN|A6PjB:L3G+
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SKOV3  M4[1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnuwNE01OCEQvF2= MYm3NuKhcA>? M1\RbmlEPTC-M{Cg{txONCCrbnjpZol1eyClZXzsJIdzd3e2aDDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= NITvZ3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MESwOVI6Pid-MkC0NFUzQTZ:L3G+
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OAW-42 NUSyZ3QxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUCwMVQxKM7:TR?= M1\qTFczyqCq MWLJR|UxhjFyIN88UUwhcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODRyNUK5Okc,OjB2MEWyPVY9N2F-
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HepG2  MnHMRZBweHSxc3nzJGF{e3OjeR?= MWC1M|ExNzJyIN88US=> M4rXflI1NzR6IHi= MV7pcoR2[2W|IHHwc5B1d3OrczDheEB1cGVibH;u[{11cW2nIHX4dI9{fXKn Mk\HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6NEK0NlUoRjJyOESyOFI2RC:jPh?=
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SKOV3 M4GwOmNmdGxiVnnhZoltcXS7IFHzd4F6 MUGxMVMxKM7:TR?= NEWyeoI1QCCq MXfk[YNz\WG|ZYOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? M1nKSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUG5NVQ5Lz5{NUWxPVE1QDxxYU6=
OVISE NETv[YlE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M{fhU|EuOzBizszN MVq0PEBp M2PETIRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= M{HvfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUG5NVQ5Lz5{NUWxPVE1QDxxYU6=
RMG2 MoHqR4VtdCCYaXHibYxqfHliQYPzZZk> M{\KN|EuOzBizszN MlvDOFghcA>? MmOy[IVkemWjc3XzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ M1fpcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUG5NVQ5Lz5{NUWxPVE1QDxxYU6=
HAC2 NGnISnRE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NIrsRmcyNTNyIN88US=> MVm3NkBp MnHE[IVkemWjc3XzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ NInSenA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUWxPVE1QCd-MkW1NVkyPDh:L3G+
KOC7C MY\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NHW0bo0yNTNyIN88US=> M2TtUlczKGh? MoXN[IVkemWjc3XzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTVzOUG0PEc,OjV3MUmxOFg9N2F-
RMG2 NGXpfo1E\WyuIG\pZYJqdGm2eTDBd5NigQ>? M1LaVVEuOzBizszN MlvoO|IhcA>? M4rU[oRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTVzOUG0PEc,OjV3MUmxOFg9N2F-
RMG1 NV\nb4prS2WubDDWbYFjcWyrdImgRZN{[Xl? NX76cnpSOS1|MDFOwG0> Ml7qO|IhcA>? M3TaSIRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= NWrJcGhtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1NVkyPDhpPkK1OVE6OTR6PD;hQi=>
H460 MoTFSpVv[3Srb36gRZN{[Xl? MWqzJO69VQ>? M{LBV|ghcA>? MoSyZoxw[2u|IH3UU3JEOSxiYX7kJGVTUy2PQWDLJIFkfGm4YYTpc44h[2:vYnnu[YQhf2m2aDDNSWsuOTZ{ NH\w[FQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[5O|g6QSd-MkW2PVc5QTl:L3G+
A549 MmnESpVv[3Srb36gRZN{[Xl? MYezJO69VQ>? NG[zZo05KGh? NFLuOW1jdG:la4OgcXRQWkNzLDDhcoQhTVKNLV3BVGsh[WO2aY\heIlwdiClb33ibY5m\CC5aYToJG1GUy1zNkK= NF;icVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[5O|g6QSd-MkW2PVc5QTl:L3G+
H460 MojzSpVv[3Srb36gRZN{[Xl? MWizJO69VQ>? MYW4JIg> MUXicI9kc3NiQVvUJIFkfGm4YYTpc44> NWTEOFJ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PVc5QTlpPkK1Olk4QDl7PD;hQi=>
A549 M3HJSGZ2dmO2aX;uJGF{e2G7 NFX3VFE{KM7:TR?= MoHmPEBp Mo\pZoxw[2u|IFHLWEBi[3SrdnH0bY9v NGHSSWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[5O|g6QSd-MkW2PVc5QTl:L3G+
H460 NHzSTWtCeG:ydH;zbZMhSXO|c3H5 NXLMSHVQOS9|IN88US=> NX;DeZJxPDhiaB?= MWjpcoR2[2W|IHHwc5B1d3Orcx?= NHnHOHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[5O|g6QSd-MkW2PVc5QTl:L3G+
A549 NVf6PYdSSXCxcITvd4l{KEG|c4PhfS=> M1zGWVEwOyEQvF2= M3vOTlQ5KGh? MXrpcoR2[2W|IHHwc5B1d3Orcx?= M1v2[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nkm3PFk6Lz5{NU[5O|g6QTxxYU6=
H460 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4ToWFAvOy1zMDFOwG0> MnLZNlQwPzJiaB?= M33xdIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHLveIghfGmvZTDhcoQh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ NXPmNnR{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PVc5QTlpPkK1Olk4QDl7PD;hQi=>
A549 M3\6WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LGfFAvOy1zMDFOwG0> NXX5dZB3OjRxN{KgbC=> MXzpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJJRqdWViYX7kJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? NXzpcWx7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PVc5QTlpPkK1Olk4QDl7PD;hQi=>
U-87 MG  NH[1[2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYW5cmQ2OjBxNECg{txO M2DC[FI1NzR6IHi= MorYbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYn;0bEB1cW2nIHHu[EBld3OnIHTldIVv\GWwdDDtZY5v\XJ? NED3dJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUmzOFI{Oid-MkW5N|QzOzJ:L3G+
HepG2 M33LTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDiSnIzOC92MDFOwG0> MVOyOE81QCCq NHTZN2VqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWgZY5lKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= M1Ln[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUO0NlMzLz5{NUmzOFI{OjxxYU6=
U-87 MG  NWLaWmhwTnWwY4Tpc44hSXO|YYm= NGDEfmozOMLizszN NH\NT203NzJ2IHi= MknTbY5kemWjc3XzJJRp\SCjdYTvdIhi\2mlIH\seZghKGG2IE[gbEB4cGmuZTDpcohq[mm2czD0bIl{KG[udYigZZQhOjSq M2mw[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUO0NlMzLz5{NUmzOFI{OjxxYU6=
HepG2 M{CxU2Z2dmO2aX;uJGF{e2G7 MXeyNOKh|ryP NFnkbIw3NzJ2IHi= MXnk[YNz\WG|ZYOgUGM{NUmLIHTl[5Ji\GG2aX;uxsBnem:vIE[gbC=> MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl|NEKzNkc,OjV7M{SyN|I9N2F-
U-87 MG  M1PmRWZ2dmO2aX;uJGF{e2G7 MkPNNlDDqM7:TR?= M3nVOlYwOjRiaB?= NV7O[oh5cW6lcnXhd4V{KHSqZTDs[ZZmdHNib3[gUGM{NUmLIHPveJJm[XSnZDD3bZRpKEOT NITsVpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUmzOFI{Oid-MkW5N|QzOzJ:L3G+
HepG2 NGi1dpRHfW6ldHnvckBCe3OjeR?= NEPh[4ozOMLizszN M2GwUFYwOjRiaB?= MXTpcoNz\WG|ZYOgeIhmKGyndnXsd{Bw\iCOQ{OtTWkh[2:2cnXheIVlKHerdHigR3E> NGPxeXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUmzOFI{Oid-MkW5N|QzOzJ:L3G+
U-87 MG  MlTxSpVv[3Srb36gRZN{[Xl? NF62OZozOMLizszN MX6yOOKhcA>? NWPlNHhncW6lcnXhd4V{KGSxdXLs[U1u\W2kcnHu[UBjd3WwZDDzeJJ2[3S3cnXz MkP0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7M{SyN|IoRjJ3OUO0NlMzRC:jPh?=
HepG2 MVLGeY5kfGmxbjDBd5NigQ>? NVXzZXNVOjEEoN88US=> MmDQNlTDqGh? M2O3N5Bzd2S3Y3XzJIFvKGmwdHXud4Uh[3m2b4DsZZNucWNidnHjeY9tcXqjdHnvckBkd3K{ZYPwc45lcW6pIITvJIEhdm:2YXLs[UBlcWyjdHH0bY9vKG:oIITo[UBGWiClaYP0[ZJvew>? MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl|NEKzNkc,OjV7M{SyN|I9N2F-
T24 BC  MWHBdI9xfG:|aYOgRZN{e2G7 NFvXXoYzNjVizszN NVXlfmFZOjRiaB?= MYTz[Y5{cXSrenXzJGJEKGOnbHzzJJRwKHOxcnHm[Y5q[i2rbnT1Z4VlKGGyb4D0c5Rq[8Li MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB7N{i3N{c,OjZyOUe4O|M9N2F-
T24 BC  NXTo[FZ1S2WubDDWbYFjcWyrdImgRZN{[Xl? MkT2NE42NzFxMj61JO69VQ>? M1vUXFI1KGh? MV3lcohidmOnczDzc5Ji\mWwaXKtbY5lfWOnZDDj[YxtKH[rYXLpcIl1gSCmZXPy[YF{\Q>? NE\i[ok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC5O|g4Oyd-Mk[wPVc5PzN:L3G+
T24 BC  NYm4d45XTnWwY4Tpc44hSXO|YYm= NGTpRlIxNjVxMT:yMlUh|ryP NUm5WHpUOyCq MXXy[YR2[2W|IITo[UBj[XOjbDDDRkB1gXKxc3nu[UBxcG:|cHjvdplt[XSrb36gcIV3\Wy|IHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ Mn3sQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyOUe4O|MoRjJ4MEm3PFc{RC:jPh?=
RBL2H3 MoHDSpVv[3Srb36gZZN{[Xl? NFy1N5VVd3irY3n0fUBqdiC{YYSgVmJNOkh|IHPlcIx{NCCPVFS9NlXPxE1? NVr4bFFtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOVM2PjVpPkKwNVU{PTZ3PD;hQi=>
PC3 MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4X0N2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHBEOyClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBIUTVyPUCuOFTPxE1? MmPSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3NEOxOFEoRjJzNUSzNVQyRC:jPh?=
NUGC3 NV3yWYh1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH3vWVVIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBPXUeFMzDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCJSUWwQVAvPTUQvF2= NVzZSIVCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1OFMyPDFpPkKxOVQ{OTRzPD;hQi=>
HCT15 M3PGbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGnZPYxIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzNTDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCJSUWwQVEvOjYQvF2= MoC3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3NEOxOFEoRjJzNUSzNVQyRC:jPh?=
MDA-MB-231 M3fvcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml;TS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxRTJwOEdOwG0> MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV2M{G0NUc,OjF3NEOxOFE9N2F-
NCI-H23 NHS4S3ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mk\oS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUmNKNUh{MzDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCJSUWwQVQvOjIQvF2= NUjUZ2ZQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1OFMyPDFpPkKxOVQ{OTRzPD;hQi=>
ACHN MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2jqZ2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGFEUE5iY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhT0l3ME20MlU3|ryP M3jiOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUSzNVQyLz5{MUW0N|E1OTxxYU6=
A549 M37VW2Z2dmO2aX;uJIF{e2G7 MWSzNEBucW6| Mn\uTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIHnuJIlve3WuaX6td5RqdXWuYYTl[EBpfW2jbjDBOVQ6KGOnbHzzJJRz\WG2ZXSgNkBpenNiYnXmc5JmKGmwc4XsbY4he3SrbYXsZZRqd25ibXXhd5Vz\WRiYX\0[ZIhOzBibXnud{BjgSCHTFnTRUwhUUN3ME21MlPPxE1? MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF|OEOwPUc,OjJzM{izNFk9N2F-
A549 MWXDfZRwfG:6aXPpeJkh[XO|YYm= Ml\ENlQhcHK| MkC4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjCyOEBpenNiYomgSmFEWyCjbnHsfZNqeyxiSVO1NF04|ryP NE[yNJU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGzPFMxQSd-MkKxN|g{ODl:L3G+
KATO III NH;4NnNEgXSxdH;4bYNqfHliYYPzZZk> MXWyOEBpenN? MWLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRXRQKEmLSTDj[YxteyCjZoTldkAzPCCqcoOgZpkhTkGFUzDhcoFtgXOrczygTWM2OD1zMj64{txO NITjeW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGzPFMxQSd-MkKxN|g{ODl:L3G+
MCF7 MY\DfZRwfG:6aXPpeJkh[XO|YYm= MmToNlQhcHK| M4myVmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JGZCS1NiYX7hcJl{cXNuIFnDOVA:OTNwM988US=> M3TlXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUO4N|A6Lz5{MkGzPFMxQTxxYU6=
PC3 NWrBSox[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYnHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDQR|Mh[2WubIOgZpkhW1KEIHHzd4F6NCCJSUWwQVAvPDUQvF2= M1PNXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Mk[2NVgyLz5{M{K2OlE5OTxxYU6=
NUGC3 M1HGUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVfFd5dCT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVlWJQ{OgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyPUCuOVTPxE1? MmLNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{Nk[xPFEoRjJ|Mk[2NVgyRC:jPh?=
HCT15 MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkjlS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGNVOTViY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxRTFwMkZOwG0> NHvEWlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K2OlE5OSd-MkOyOlYyQDF:L3G+
MDA-MB-231 M1T6VWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NELQ[JRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIJ6KFOUQjDhd5NigSxiR1m1NF0zNjh4zszN NUjrNINqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOlYyQDFpPkKzNlY3OThzPD;hQi=>
NCI-H23 MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUi0XmlRT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyN{Bk\WyuczDifUBUWkJiYYPzZZktKEeLNUC9OE4zOc7:TR?= NGjnd|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K2OlE5OSd-MkOyOlYyQDF:L3G+
ACHN NELJRnRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYDsRY43T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hSUOKTjDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTB;ND61Ou69VQ>? MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ4NkG4NUc,OjN{Nk[xPFE9N2F-
A549 MmnaSpVv[3Srb36gZZN{[Xl? NWfTUZdNOiCqcoO= NG\zVopKdmirYnn0bY9vKG:oIFHreEBxcG:|cHjvdplt[XSrb36gbY4hcHWvYX6gbY5{fWyrbj3zeIlufWyjdHXkJGE2PDliY3XscJMhcW6ldXLheIVlKG[xcjCyJIhzeyCycnnvdkB1dyCrboP1cIlvNWmwZIXjeIlwdiCvZXHzeZJm\CCjZoTldkA{OCCvaX7zJIJ6KEWOSWPBMEBKSzVyPUWuN:69VQ>? NX3hXHdHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NVUxQDNpPkKzOFE2ODh|PD;hQi=>
A549 MXnDfZRwfG:6aXPpeJkh[XO|YYm= MorlR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{BjgSCobH;3JIN6fG:vZYTybYMh[W6jbInzbZMtKEmFNUC9O:69VQ>? M3fHVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEG1NFg{Lz5{M{SxOVA5OzxxYU6=
KATO III NX[2VmxOS3m2b4TvfIlkcXS7IHHzd4F6 NIn4WG9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSVSRIFnJTUBk\WyuczDifUBndG:5IHP5eI9u\XS{aXOgZY5idHm|aYOsJGlEPTB;MUKuPO69VQ>? MoHLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2MUWwPFMoRjJ|NEG1NFg{RC:jPh?=
MCF7 M4CyfWN6fG:2b4jpZ4l1gSCjc4PhfS=> NWPsUGJyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCkeTDmcI94KGO7dH;t[ZRzcWNiYX7hcJl{cXNuIFnDOVA:OTNwM988US=> NGLKXHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SxOVA5Oyd-MkO0NVUxQDN:L3G+
PC3 MmHBRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MlHaRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyPUCuOFTPxE1? NHHFb2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W2O|k2OCd-MkO1Olc6PTB:L3G+
NUGC3 MULBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MWLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6XR1OzJINmdGy|IHL5JHNTSiCjc4PhfUwhT0l3ME2wMlU1|ryP MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV4N{m1NEc,OjN3Nke5OVA9N2F-
HCT15 NIHnZmFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NIPTVHhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFE2KGOnbHzzJIJ6KFOUQjDhd5NigSxiR1m1NF0yNjJ3zszN NETnOnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W2O|k2OCd-MkO1Olc6PTB:L3G+
MDA-MB-231 NHTjWlhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M4nQSWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCkeTDTVmIh[XO|YYmsJGdKPTB;Mj64Ou69VQ>? NXKz[JIyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1Olc6PTBpPkKzOVY4QTVyPD;hQi=>
NCI-H23 NWfX[XRISW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NYXFNos2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDJ|IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OD12LkKx{txO NGLpVVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W2O|k2OCd-MkO1Olc6PTB:L3G+
ACHN Mn;ZRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NYjrPXVqSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBR2hPKGOnbHzzJIJ6KFOUQjDhd5NigSxiR1m1NF01NjV4zszN NYfO[4N6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1Olc6PTBpPkKzOVY4QTVyPD;hQi=>
PC3 MmXpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mom5OFghcHK| NF3DPItIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBRSzNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3ME2wMlQ1|ryP MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB7NUe1PUc,OjRyOUW3OVk9N2F-
NUGC3 NH3mToNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUDVWFI4PDhiaILz MUTHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOWWdEOyClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyPUCuOVTPxE1? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB7NUe1PUc,OjRyOUW3OVk9N2F-
HCT15 NHrBd5pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVi0PEBpenN? NEny[YtIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzNTDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwQVEvOjYQvF2= MlHZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyOUW3OVkoRjJ2MEm1O|U6RC:jPh?=
MDA-MB-231 M4HwTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH\NV|k1QCCqcoO= NYXkW5lFT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyPUKuPFbPxE1? NFzVRmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVc2QSd-MkSwPVU4PTl:L3G+
NCI-H23 NXXDdGc{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUW0PEBpenN? NFO2eYlIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKzJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFfJOVA:PC5{Md88US=> NULpU3BKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVU4PTlpPkK0NFk2PzV7PD;hQi=>
ACHN NEjrOWtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NV7JNHNZPDhiaILz NVjjVGpvT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hSUOKTjDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwQVQvPTcQvF2= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB7NUe1PUc,OjRyOUW3OVk9N2F-
A549 MWfDfZRwfG:6aXPpeJkh[XO|YYm= NXT5TpozOjRidH:gO|IhcHK| MlT2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjCyOEB1dyB5MjDodpMh[nliaHHlcY9kgXSxbXX0dpktKEmFNUC9OE4yP87:TR?= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyME[yNEc,OjR7MEC2NlA9N2F-
Rosetta cells MVjGeY5kfGmxbjDhd5NigQ>? MoPVTY5pcWKrdHnvckBw\iC5aXzkMZR6eGViaIXtZY4hWDN6YXzwbIEhVUGSSzDlfJBz\XO|ZXSgbY4hTXOlaHXybYNpcWFiY3;sbUBTd3OndIThJINmdGy|LDDJR|UxRTFwMt88US=> NVrxcZJTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyO|Q{OTZpPkOxNlc1OzF4PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT / p-S6K1 / S6K1 ; 

PubMed: 25519148     


The effect of perifosine on AKT-mTOR activation in vitro. RMG1 and RMG2 cells were treated with 0, 3, 10, 30 or 50 μM perifosine for 6 h in the presence of 10% FBS. Cells were harvested, and equivalent amounts (30 μg) of protein were subjected to SDS-PAGE and blotted with anti-phospho-AKT (Ser473), anti-AKT, anti-phospho-S6K1 (Thr389), anti-S6K1, or anti-β-actin antibodies.

PARP; 

PubMed: 25519148     


Perifosine induces apoptosis. RMG1 and RMG2 cells were treated with or without 30 μM perifosine for 24 h. Cells were harvested, and the effect of perifosine was evaluated by western blotting

p-mTOR / mTOR / Raptor / Rictor / p-p70S6K / p70S6K / p-4EBP1 / 4EBP1 / c-Myc / Cyclin D1; 

PubMed: 19920197     


The indicated cell lines were treated with the given concentrations of perifosine (PRFS) for 8 h.

p-PDK1 / p-GSK3α/β / p-S6R ; 

PubMed: 17761832     


BCWM.1 cells were cultured with perifosine for 6 hours with doses that ranged from 2 to 20 μM. Whole cell lysates were subjecting to Western blotting using anti–p-Akt ser473, -Akt, –p-PDK1, –p-GSK3α/β, –p-S6R, and α-tubulin antibodies.

25519148 19920197 17761832
Growth inhibition assay
Cell viability; 

PubMed: 28332584     


Cell survival measured by MTT assay and IC50 of perifosine in a panel of eleven human cancer cells.

28332584
体内研究 Perifosine和temozolomide联用在体内可减少肿瘤的增殖(PDGF驱动胶质瘤发生)。结果表明,Perifosine是一种有效抑制神经胶质瘤的药物并且可能是治疗神经胶质瘤的候选药物,在神经胶质瘤中的Akt和Ras-ERK1/2途径常常被激活。[2] 与PBS处理的对照动物相比,日服和周服Perifosine显著减少人MM肿瘤的生长并提高成活率。[3] Perifosine诱导血小板和白细胞增多,增加髓小鼠骨髓和脾脏,而它会导致移植骨髓瘤的凋亡。[5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[3]
- 合并

Akt激酶活性:

在MM.1S细胞中添加或不添加Perifosine(5 μM,6小时),然后用IL-6(20 ng/mL,10分钟)刺激。体外Akt激酶活性测定试验使用Akt激酶检测试剂盒。
细胞实验:[2]
- 合并
  • Cell lines: 人脑胶质瘤细胞系
  • Concentrations: 0, 15, 30和45 μM
  • Incubation Time: 48小时
  • Method: 细胞在含10%FCS的培养基中培养48小时,添加不同浓度的Periosine。细胞活力通过3-(4,5 - 二甲基吡啶-2-基)-2,5-二苯基溴化镁(MTT)法确定。 (细胞增殖试剂盒I;罗氏)。在590nm处的吸光度是用96孔读板仪记录。
    (Only for Reference)
动物实验:[3]
- 合并
  • Animal Models: MM.1S MM细胞在BNX裸鼠(5〜6周龄)的右腰部皮下接种。
  • Dosages: 250 mg/kg/wk或者36 mg/kg/d
  • Administration: 口服
    (Only for Reference)

溶解度 (25°C)

体外 Water 8 mg/mL (17.32 mM)
DMSO Insoluble
Ethanol '15 mg/mL
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
water
8mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 461.66
化学式

C25H52NO4P

CAS号 157716-52-4
储存条件 粉状
溶于溶剂
别名 NSC639966, D21266

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01224730 Completed Drug: perifosine Cancer AEterna Zentaris January 24 2012 Phase 1
NCT01049841 Completed Drug: perifosine + temsirolimus Pediatric Solid Tumors Memorial Sloan Kettering Cancer Center|University of Wisconsin Madison|Duke University|NATL COMP CA NETWORK|Pfizer|AEterna Zentaris January 2010 Phase 1
NCT01048580 Completed Drug: Perifosine|Drug: Capecitabine Colon Cancer AEterna Zentaris|SCRI Development Innovations LLC October 2009 Phase 1
NCT00776867 Completed Drug: perifosine Solid Tumors Memorial Sloan Kettering Cancer Center|University of Wisconsin Madison|Duke University|AEterna Zentaris October 2008 Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

Akt Signaling Pathway Map

Akt Inhibitors with Unique Features

相关Akt产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID