Ponatinib (AP24534)

目录号：S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534)是一种新型有效的多靶点抑制剂，在无细胞试验中作用于Abl，PDGFRα，VEGFR2，FGFR1和Src，IC50分别为0.37 nM，1.1 nM，1.5 nM，2.2 nM和5.4 nM。

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RMB 819.31 现货
RMB 903.01 现货
RMB 3034.48 现货
RMB 7959.08 现货
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客户使用Selleck该产品发表文献31篇：

客户使用该产品的6个实验数据：

  • Immunoblot of H23 cells treated with trametinib (25 nM), ponatinib (750 nM), or their combination for the times shown.

    Nature, 2016, 534(7609):647-51. Ponatinib (AP24534) purchased from Selleck.

     

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

  • Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

    The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

  • Western blot analysis of lysates of Ba/F3 cells expressing BCR/ABL and BCR/ABL-T315I using antibodies directed against: c-ABL, ABL-Y245 (anti-phospho-ABL), Crkl, phosphorylated Crkl, STAT5, phosphorylated STAT5 (anti-phospho-STAT5) and β-tubulin (anti-β-tubulin). Molecular mass references (kDa) are presented, and c-ABL and β-Tubulin were used as a loading control.

    Leukemia, 2015, 29(5):1104-14. Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

产品描述 Ponatinib (AP24534)是一种新型有效的多靶点抑制剂，在无细胞试验中作用于Abl，PDGFRα，VEGFR2，FGFR1和Src，IC50分别为0.37 nM，1.1 nM，1.5 nM，2.2 nM和5.4 nM。
靶点
Abl [1]
(Cell-free assay)		 PDGFRα [1]
(Cell-free assay)		 VEGFR2 [1]
(Cell-free assay)		 FGFR1 [1]
(Cell-free assay)		 c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外研究

Ponatinib是有效的可用于口服的多靶点激酶抑制剂，作用于野生型细胞,及T315I 突变细胞IC50分别为1.2和8.8nM。[1] Ponatinib抑制Ba/F3衍生细胞系的增殖。[2] Ponatinib作用于表达野生型或T315I突变型BCR-ABL的CML细胞系，有效抑制BCR-ABL调节的信号。Ponatinib阻断在细胞瘤筛选时产生抗性突变。[3] Ponatinib也抑制VEGFR和FGFR家族激酶，在体外抑制FLT3, KIT, FGFR1,和PDGFRa激酶活性时IC50分别为13, 13, 2, 和1 nM.[4]Ponatinib抑制全部4种RTKs磷酸化，存在剂量依赖性，IC50值为0.3到20 nM。然而，Ponatinib抑制表达野生型FLT3的RS4;11细胞时IC50>100 nM。
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NXnIT3JET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMECwNFAxODN3OTFOwG0> MVfTRW5ITVJ?
MV-4-11 Mn3DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrtTWM2OD1yLkCwNFA6PTZizszN NXHCWopXW0GQR1XS
MEG-01 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrlfGdKSzVyPUCuNFAxOTJ6IN88US=> MWjTRW5ITVJ?
LAMA-84 NH20NpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYq3RWJZUUN3ME2wMlAxODF4NTFOwG0> MX\TRW5ITVJ?
CGTH-W-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3qwRWlEPTB;MD6wNFE3QSEQvF2= MkTTV2FPT0WU
KASUMI-1 NGHCfG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMECyNVch|ryP MVjTRW5ITVJ?
BE-13 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnjTWM2OD1yLkCwNlU6KM7:TR?= M3PEVnNCVkeHUh?=
CTV-1 Ml30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHHWWw5UUN3ME2wMlAxPTJzIN88US=> M3\McHNCVkeHUh?=
NKM-1 MkTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMEC2OVUh|ryP M2ribXNCVkeHUh?=
MONO-MAC-6 NHnRc4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXntRXBuUUN3ME2wMlAxQDN5IN88US=> MV7TRW5ITVJ?
A204 NITnTJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMEGyNVgh|ryP M{T2dXNCVkeHUh?=
GDM-1 M3PQeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfBPJVKSzVyPUCuNFE5OzNizszN MUDTRW5ITVJ?
AN3-CA MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMEG4O|Mh|ryP M3eze3NCVkeHUh?=
BL-70 NH;SOVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Xve2lEPTB;MD6wNlE6QSEQvF2= MlH1V2FPT0WU
Daudi MnrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMEK1N|ch|ryP NV3qO5V1W0GQR1XS
KU812 MnmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\mT2lEPTB;MD6wNlg1QCEQvF2= Ml7aV2FPT0WU
KG-1 NGjITnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWflOGhwUUN3ME2wMlA{Ojl2IN88US=> MmftV2FPT0WU
DOHH-2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\wTmlEPTB;MD6wOFgxOyEQvF2= Mlj6V2FPT0WU
HuO9 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDLTWM2OD1yLkC1OFQ5KM7:TR?= M{nQbnNCVkeHUh?=
EB2 NVPh[WZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVy1OGpJUUN3ME2wMlA2PTd4IN88US=> NIHTSYZUSU6JRWK=
G-402 M{foVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwME[zOFEh|ryP NVvoRnZiW0GQR1XS
SU-DHL-1 M17WeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwME[zO|kh|ryP NEi0XJhUSU6JRWK=
NCI-H719 M2L0e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMEe4PFgh|ryP M4DpWHNCVkeHUh?=
MLMA NF;XTXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXLTWM2OD1yLkC5NFYh|ryP M2LHUHNCVkeHUh?=
KM12 NYHFZ4RET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\vO3ZKSzVyPUCuNFk4OzdizszN NUC2NJpnW0GQR1XS
SUP-T1 NYKxbVRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvLO5hKSzVyPUCuNFk6QDJizszN MUDTRW5ITVJ?
MZ1-PC NWjlO5dRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMUGzN|Yh|ryP MoLTV2FPT0WU
MFE-296 NWXxWIZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PZTWlEPTB;MD6xNVg{QSEQvF2= NF7Q[lRUSU6JRWK=
ALL-PO NV7ONGZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3yfZBKSzVyPUCuNVI1PDNizszN Mo\wV2FPT0WU
GB-1 NGraS|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMUK1NVIh|ryP MUTTRW5ITVJ?
SIG-M5 M1fvUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rPdGlEPTB;MD6xN|M4KM7:TR?= MVHTRW5ITVJ?
P30-OHK Mo\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwMUW2O|Ih|ryP MWXTRW5ITVJ?
NCI-H716 NIq1WZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwMU[yOlYh|ryP NYTVb41SW0GQR1XS
MPP-89 MlvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\6c|lKSzVyPUCuNVY6OzNizszN MVrTRW5ITVJ?
SF126 NGLSOohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPsNJVKSzVyPUCuNVcxPjNizszN NV3adVFLW0GQR1XS
CTB-1 NHWzVGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMUezNVYh|ryP MWjTRW5ITVJ?
CA46 NWLpRYdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV35enQ{UUN3ME2wMlE4PDh7IN88US=> MonPV2FPT0WU
NCI-H520 NFzOR5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PnXWlEPTB;MD6xO|c{OiEQvF2= MWPTRW5ITVJ?
CAL-85-1 NUjQWo5wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HXemlEPTB;MD6xO|kzPyEQvF2= MkGzV2FPT0WU
NCI-H2342 NXnFTpJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vOTmlEPTB;MD6xPFU4PyEQvF2= M3;2[nNCVkeHUh?=
697 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHMdo9KSzVyPUCuNVg5PzFizszN NWjsNI9nW0GQR1XS
NY MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMUmyPFch|ryP NHX1SphUSU6JRWK=
T98G NES0O5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMUmzNVgh|ryP NYPmcZhrW0GQR1XS
NCI-H1703 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkCzTWM2OD1yLkG5OlE2KM7:TR?= NEToS4FUSU6JRWK=
NCI-H2087 MlX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmS3TWM2OD1yLkKwOFM6KM7:TR?= MlfmV2FPT0WU
PF-382 NVzTR457T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\1TWM2OD1yLkKwPFc{KM7:TR?= Mn3wV2FPT0WU
HCT-116 MnewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMkGwOlkh|ryP M{mybHNCVkeHUh?=
CAKI-1 M4f5[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrLS3hUUUN3ME2wMlIyPjZ4IN88US=> NWfBeXRiW0GQR1XS
CCF-STTG1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMkK0O|Uh|ryP NF3vXXpUSU6JRWK=
D-392MG NFjYb2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfnfnlKSzVyPUCuNlMyPzdizszN NIXlb2xUSU6JRWK=
RT-112 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrTTWM2OD1yLkKzO|k2KM7:TR?= NHrjO2lUSU6JRWK=
MES-SA M4HTRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMkSxPFch|ryP MlHLV2FPT0WU
LC-2-ad MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{S0TWlEPTB;MD6yOFI3PSEQvF2= NU[5XHBIW0GQR1XS
NOS-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4r0fWlEPTB;MD6yOFM3PyEQvF2= M1PPd3NCVkeHUh?=
NALM-6 NFLER5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMkW1OFMh|ryP NFzKc3RUSU6JRWK=
TE-15 MmL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLCTWM2OD1yLkK2NFkyKM7:TR?= NV3TbIR6W0GQR1XS
786-0 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMk[yNlgh|ryP MYPTRW5ITVJ?
IST-MES1 NXHncYRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjYNWVKSzVyPUCuNlY5OjlizszN MXzTRW5ITVJ?
KYSE-180 M4W2RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMk[4PVEh|ryP MXzTRW5ITVJ?
YT MmXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjTTWM2OD1yLkK2PVc1KM7:TR?= M1;UUHNCVkeHUh?=
A427 NVHmXIZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMkeyOlQh|ryP MkTzV2FPT0WU
KYSE-450 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvjUZV3UUN3ME2wMlI4OzJ7IN88US=> NWnC[ZF6W0GQR1XS
HuH-7 Mo\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnEbWRSUUN3ME2wMlI4PzZ|IN88US=> MYfTRW5ITVJ?
CAS-1 NYXvWoc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHpbnRSUUN3ME2wMlI5OzB|IN88US=> MkfLV2FPT0WU
KURAMOCHI NHPE[XBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXt[nFKSzVyPUCuNlg1OTlizszN Mn;WV2FPT0WU
ACHN NYX2dlR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMkmzNlMh|ryP NYfGXpRsW0GQR1XS
HGC-27 MnvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rOZmlEPTB;MD6yPVM2OyEQvF2= MXnTRW5ITVJ?
A172 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XwWmlEPTB;MD6yPVU4PyEQvF2= NWTEVINEW0GQR1XS
SNU-449 M1HRfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETCWVRKSzVyPUCuNlk6PjRizszN NYrYTmVVW0GQR1XS
SW982 NYPFTpl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkn3TWM2OD1yLkK5PVc5KM7:TR?= M{LwOnNCVkeHUh?=
EFO-21 NULL[Hp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwM{C0NVEh|ryP NVjM[pRyW0GQR1XS
NCI-H2030 Mo\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnn0TWM2OD1yLkOxNVY1KM7:TR?= MlT6V2FPT0WU
HT-144 NEfGUotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwM{GyPEDPxE1? Ml;NV2FPT0WU
MFE-280 NF\KXINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzLVI9QUUN3ME2wMlMyPDV|IN88US=> M1;BWHNCVkeHUh?=
SK-LU-1 NXnuTmVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljLTWM2OD1yLkOxOFY3KM7:TR?= NU\2e|BiW0GQR1XS
NCI-H2052 M4Lh[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljnTWM2OD1yLkOxOFg1KM7:TR?= NXfh[odsW0GQR1XS
SK-HEP-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzHPYVvUUN3ME2wMlM{OzZ6IN88US=> M3HMR3NCVkeHUh?=
QIMR-WIL MkXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LxbGlEPTB;MD6zN|QzPCEQvF2= MlL5V2FPT0WU
A2780 M4fkfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;YeWRKSzVyPUCuN|Q{ODRizszN MVHTRW5ITVJ?
ACN M3nHVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwM{S4O|Mh|ryP NIXMWmpUSU6JRWK=
BxPC-3 MnvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHXXYVWUUN3ME2wMlM1QTh7IN88US=> NIPVUHlUSU6JRWK=
BCPAP NH;SNIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[5RmhKSzVyPUCuN|YxODFizszN NW\UdoFZW0GQR1XS
HOP-62 Mk\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPRTWM2OD1yLkO2NVA3KM7:TR?= NEPB[IVUSU6JRWK=
SW1710 NYfKNJpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jDRWlEPTB;MD6zOlQ2PSEQvF2= NHO5SpFUSU6JRWK=
OPM-2 M2TuUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrSRY1MUUN3ME2wMlM3PDd|IN88US=> NGrlfolUSU6JRWK=
DBTRG-05MG NVnpSIt[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrKbZlKSzVyPUCuN|gxPTRizszN MX7TRW5ITVJ?
SK-MEL-24 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XDOWlEPTB;MD6zPVc6OSEQvF2= NVLYVYVXW0GQR1XS
8305C NHLrVJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHqTWM2OD1yLkO5O|k{KM7:TR?= NHj1cWVUSU6JRWK=
OVCAR-4 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\JZ3JKSzVyPUCuOFE2QDZizszN MkLJV2FPT0WU
HLE MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnKOpJKSzVyPUCuOFE5PiEQvF2= NFfyZoFUSU6JRWK=
NCI-H747 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHSyWHpKSzVyPUCuOFIyOzdizszN MVXTRW5ITVJ?
SW780 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\4WGd3UUN3ME2wMlQzOzR4IN88US=> MYXTRW5ITVJ?
KYSE-150 NWfKWlNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\OOodKSzVyPUCuOFI1OTVizszN Mk\UV2FPT0WU
H4 NF3SfVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwNEK0OVEh|ryP NU\PdoZJW0GQR1XS
SW1088 M{[0d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2juXmlEPTB;MD60OFM6KM7:TR?= NHK2U|ZUSU6JRWK=
SF268 NXvs[o9wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PTWWlEPTB;MD60OFg3KM7:TR?= MkL1V2FPT0WU
RT4 M1m0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPUPJVKSzVyPUCuOFUyOTFizszN MVPTRW5ITVJ?
NCI-H522 NGXKSYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwNEWyO{DPxE1? MWHTRW5ITVJ?
LCLC-97TM1 M4jpS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwNE[xPVUh|ryP NVr4V4lYW0GQR1XS
CAL-39 NFjoWZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzzTWM2OD1yLkS2OVE6KM7:TR?= NGLXOYdUSU6JRWK=
CAL-120 Mnu5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrUR5B{UUN3ME2wMlQ4PjR|IN88US=> M3rVRnNCVkeHUh?=
ESS-1 M1H0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7NXpFDUUN3ME2wMlQ4QDJzIN88US=> M1:xUXNCVkeHUh?=
KARPAS-45 NH\6ZZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rYVGlEPTB;MD60PFk{OyEQvF2= NYHv[5BYW0GQR1XS
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A498 Mo[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTFwOEGyPFIh|ryP MYDTRW5ITVJ?
NCI-H810 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHYfGlKUUN3ME2xMlgyPjB4IN88US=> NEf3O2lUSU6JRWK=
SK-NEP-1 M1HSSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfJZ3dKSzVyPUGuPFM4PjdizszN MkfhV2FPT0WU
D-542MG NV3sd|BMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlm5TWM2OD1zLki1PFUyKM7:TR?= M{j4WXNCVkeHUh?=
KNS-42 MoDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTFwOE[yOlYh|ryP NULJRYh4W0GQR1XS
NCI-H2452 M{[xRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTFwOEmwO|Qh|ryP MUnTRW5ITVJ?
SK-MEL-2 M3nrdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HXXmlEPTB;MT65NFI4OSEQvF2= MX;TRW5ITVJ?
OVCAR-5 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DKZWlEPTB;MT65NFY4PSEQvF2= NEPTVllUSU6JRWK=
SNG-M MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\oU2lEPTB;MT65OVg2QCEQvF2= MlzzV2FPT0WU
A673 NYn5PJJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnKZ|RRUUN3ME2xMlk4PTF4IN88US=> MWjTRW5ITVJ?
L-428 NGSyZZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTFwOUmxO|kh|ryP M4O2[HNCVkeHUh?=
KM-H2 M2C3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfsVItKSzVyPUKuNFExQSEQvF2= NUXRWpBSW0GQR1XS
MC-IXC M1ezNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXOxcXM5UUN3ME2yMlAzOjd|IN88US=> Mk\zV2FPT0WU
COLO-678 M1rx[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HkUGlEPTB;Mj6wOFIxPyEQvF2= NUi5N3VPW0GQR1XS
MEL-JUSO NIXiSllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PxemlEPTB;Mj6wO|g2OSEQvF2= MWTTRW5ITVJ?
HCC38 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fFZWlEPTB;Mj6wPFQ{OyEQvF2= NV7Ye3BKW0GQR1XS
UACC-62 M{TXSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlq2TWM2OD1{LkC4PFU2KM7:TR?= NWLKVm1oW0GQR1XS
OAW-42 NYPiW3FET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHQUXlKSzVyPUKuNFk4OTFizszN NHe3cIVUSU6JRWK=
LB996-RCC MnLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFz1W3hKSzVyPUKuNVM5OTdizszN NHnzTXJUSU6JRWK=
COR-L105 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7GTWM2OD1{LkG2N|c{KM7:TR?= NX3FSGt1W0GQR1XS
RCC10RGB NHPiVJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjLfW1KSzVyPUKuNVg2PzZizszN NW\RRoN{W0GQR1XS
A431 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWKyUW5oUUN3ME2yMlE6ODF7IN88US=> MlLWV2FPT0WU
NCI-H292 M{fuUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXy1Rpd{UUN3ME2yMlI{QTVzIN88US=> NVzqUHZXW0GQR1XS
SK-UT-1 NGrMSZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnpeWtKSzVyPUKuN|MyQDRizszN MXHTRW5ITVJ?
PANC-08-13 NY\s[pRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXK[ZBTUUN3ME2yMlM{OjN3IN88US=> M1\iR3NCVkeHUh?=
ST486 MkLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmH3TWM2OD1{LkSxNFQ5KM7:TR?= NX36U5E4W0GQR1XS
SJSA-1 NV3vWpZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Dj[2lEPTB;Mj60NVI4OSEQvF2= MnK2V2FPT0WU
RKO MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\vXJhKSzVyPUKuOFIxOjlizszN MUjTRW5ITVJ?
NCI-H1793 NVjiUY9UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXJNZBxUUN3ME2yMlQ1ODJ7IN88US=> MVnTRW5ITVJ?
639-V NUPNR3FsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1niRmlEPTB;Mj60OVM5OiEQvF2= NX;uNWF2W0GQR1XS
ES3 NHToUG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTJwNEm3N|ch|ryP NYrhfFJuW0GQR1XS
NCI-H1792 NUn3dWJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjqbIxMUUN3ME2yMlU3QDJ4IN88US=> M37YSnNCVkeHUh?=
NCI-H1651 NWruZ5M1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTJwNUiyNUDPxE1? MlfJV2FPT0WU
SN12C M4TqTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\HVWxKSzVyPUKuOVg1QDdizszN M1ux[XNCVkeHUh?=
COLO-679 NEDlUItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTJwNUi2NFUh|ryP MnXLV2FPT0WU
U-118-MG NXTLV4VlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLGVolKSzVyPUKuOVg5PzJizszN Mnz3V2FPT0WU
Ramos-2G6-4C10 NYHCdWVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4O1S2lEPTB;Mj62OFgxPyEQvF2= NY\6fIJoW0GQR1XS
HCT-15 M{DOc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUKyfJlzUUN3ME2yMlY5Pzl{IN88US=> NHLBcZBUSU6JRWK=
MDA-MB-157 MnzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTJwN{C3OFch|ryP NUHVeGk1W0GQR1XS
K5 MnG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWCwNo5jUUN3ME2yMlcyQDR3IN88US=> MVrTRW5ITVJ?
MKN45 Mn7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLBTWM2OD1{LkezN|Y3KM7:TR?= MVvTRW5ITVJ?
DMS-273 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTJwN{W2N|Ih|ryP MVzTRW5ITVJ?
C8166 MnzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnObVF7UUN3ME2yMlc5PTF|IN88US=> NUG4bmo1W0GQR1XS
Calu-3 NWXBfWRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTJwN{i5Olkh|ryP NGjId2RUSU6JRWK=
SNB75 NYLFPWY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTJwOEi1N|Uh|ryP NWDCW|RkW0GQR1XS
BFTC-905 NEn6dJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTJwOUCxPVEh|ryP NF;6bFRUSU6JRWK=
C-4-II NULhbZpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYe5THc5UUN3ME2yMlkyOzV|IN88US=> MWfTRW5ITVJ?
MS-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnKxTWM2OD1{Lkm2O|Y6KM7:TR?= NV\vWHFIW0GQR1XS
A375 Mm\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LydmlEPTB;Mz6wPFE5PCEQvF2= NWjYUmJ5W0GQR1XS
KYSE-70 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTNwMEi4PFIh|ryP MUnTRW5ITVJ?
KYSE-510 NGWy[ZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIqycpFKSzVyPUOuNVA6QTVizszN NGTZOHRUSU6JRWK=
LN-405 MnnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3exWmlEPTB;Mz6xN|UyQCEQvF2= NWr3c5VHW0GQR1XS
BOKU MlHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTNwMUSyOVYh|ryP M4L2WnNCVkeHUh?=
TE-10 MlPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHGTWM2OD1|LkG3N|YzKM7:TR?= NEHqU|RUSU6JRWK=
MKN1 NGnKbpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LncmlEPTB;Mz6xPFQ5OyEQvF2= MWfTRW5ITVJ?
M059J Mlf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHP6VGJKSzVyPUOuNlAyPzNizszN NVm3dWdYW0GQR1XS
GOTO MmfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIH5bnVKSzVyPUOuNlIxOzlizszN MXLTRW5ITVJ?
DK-MG M3\oUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTNwMkW5O|Yh|ryP NEHwTXdUSU6JRWK=
NCI-H727 Ml\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTNwMk[1PEDPxE1? M3;J[3NCVkeHUh?=
NB12 MoPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nEVWlEPTB;Mz6zN|IzPCEQvF2= NH7XcY5USU6JRWK=
DOK NGP4fJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTNwM{[xPFYh|ryP M3v5O3NCVkeHUh?=
KYSE-410 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGT1VYlKSzVyPUOuN|YzQDdizszN MX;TRW5ITVJ?
AM-38 NEnCOodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHYZmFKSzVyPUOuN|gxPTFizszN NIjsSZlUSU6JRWK=
GR-ST M2rqOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\M[2lEPTB;Mz60OVc{OiEQvF2= NGfiN4NUSU6JRWK=
D-247MG NHjUTVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofnTWM2OD1|LkS4NlY{KM7:TR?= NF3z[oVUSU6JRWK=
TE-8 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHqNmoyUUN3ME2zMlQ6OzN|IN88US=> NXK5c4FCW0GQR1XS
LS-411N NHTjS5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHqdFl1UUN3ME2zMlQ6Pjl{IN88US=> NYq1bZlvW0GQR1XS
SK-MES-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofMTWM2OD1|LkW2OFM{KM7:TR?= NWjkNnRQW0GQR1XS
SF295 M{HORWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVq0PFhiUUN3ME2zMlYyPTV{IN88US=> MVHTRW5ITVJ?
SK-MEL-30 NVfQ[YdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;2eWZiUUN3ME2zMlY2QTJzIN88US=> NH\ENopUSU6JRWK=
LB2241-RCC Mn70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTNwNk[yOkDPxE1? NGDQZ|JUSU6JRWK=
PC-14 NIrUR5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17aO2lEPTB;Mz62OlQ{PyEQvF2= MVfTRW5ITVJ?
EW-7 NH\XUZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHK[2k2UUN3ME2zMlY4Pjl|IN88US=> M{nLU3NCVkeHUh?=
NMC-G1 MnzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoH4TWM2OD1|LkexPFM4KM7:TR?= NVH6bmg{W0GQR1XS
TE-441-T M{n1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTNwN{OwNlgh|ryP MkXJV2FPT0WU
NCI-H1618 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\kUmtKSzVyPUOuPFE5PzVizszN MWDTRW5ITVJ?
PANC-03-27 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfwcXFVUUN3ME2zMlgyQTF4IN88US=> M{TZd3NCVkeHUh?=
NCI-H2228 M4XLNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nBTmlEPTB;Mz64N|EzPiEQvF2= M2fhSHNCVkeHUh?=
CAPAN-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfYbpIxUUN3ME2zMlg4ODB7IN88US=> MVPTRW5ITVJ?
KLE M4rBOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTNwOUC2O{DPxE1? MlHRV2FPT0WU
Becker NF;2PVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrvTWM2OD1|LkmyPFQ6KM7:TR?= NF7VT4JUSU6JRWK=
SK-PN-DW MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTOTWM2OD12LkC3PVc1KM7:TR?= NX31dVlNW0GQR1XS
Hs-578-T NEjtPZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPlSm5XUUN3ME20MlA5OzB4IN88US=> NWfPNXZFW0GQR1XS
RS4-11 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTRwMUGyOVUh|ryP NVjrcVU3W0GQR1XS
D-502MG MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HoRWlEPTB;ND6xOlk6PyEQvF2= Mn\nV2FPT0WU
GI-1 MmmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTRwMkiyPVkh|ryP NIX3SJVUSU6JRWK=
NCI-H209 MlXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHiTWM2OD12LkOzO|gh|ryP MXjTRW5ITVJ?
SK-OV-3 NX\EfY5TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPqTWM2OD12LkS4NVQ6KM7:TR?= NWnFZYZSW0GQR1XS
LOUCY M1LPbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{P0S2lEPTB;ND60PFQ{OiEQvF2= NWTJbm9sW0GQR1XS
NCI-H69 NYHuRVRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPYRYpGUUN3ME20MlUyPzl|IN88US=> M4\VSXNCVkeHUh?=
SCC-9 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm1[lBkUUN3ME20MlU{OTd{IN88US=> MWHTRW5ITVJ?
NCI-H526 M{XmXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTRwNUmyPVMh|ryP M{XBSnNCVkeHUh?=
NCI-H2170 MlX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3m3O2lEPTB;ND62Olc4OSEQvF2= MYPTRW5ITVJ?
SR MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\2TWM2OD12LkewNFQ5KM7:TR?= MULTRW5ITVJ?
CMK MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETZZoZKSzVyPUSuO|IyODFizszN MoTKV2FPT0WU
COLO-829 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHYeHB5UUN3ME20Mlc4ODR|IN88US=> NXXVW2ZFW0GQR1XS
HuO-3N1 M3TnO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXtV4lKSzVyPUSuPFMzQDFizszN M1zFWnNCVkeHUh?=
5637 NHf5OmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnOZ4V6UUN3ME20MlkxPDh5IN88US=> Mn;iV2FPT0WU
A253 M3zXZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\nTWM2OD12Lkm3O|A5KM7:TR?= M3nWeXNCVkeHUh?=
NB10 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjVTWM2OD13LkC3OFk4KM7:TR?= Ml3BV2FPT0WU
SF539 M{DhXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvoVFNKSzVyPUWuNFk6PTlizszN NEDkWZJUSU6JRWK=
HAL-01 MmjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEOwTI5KSzVyPUWuNVQ3PDVizszN M4n0PXNCVkeHUh?=
MHH-ES-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHSTWM2OD13LkG2PVI2KM7:TR?= NGXCZXZUSU6JRWK=
DEL M1zZTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjCPHJKSzVyPUWuNlc2QDJizszN NXzFR2hCW0GQR1XS
NCI-H1299 Mn3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rx[2lEPTB;NT6zOVAxPyEQvF2= MmfXV2FPT0WU
ChaGo-K-1 M37ndmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnP1TWM2OD13LkO1NVA4KM7:TR?= MX\TRW5ITVJ?
HMV-II NXr1[mxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHnWFI{UUN3ME21MlM6PDNizszN MXPTRW5ITVJ?
NB69 MlXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzNTWM2OD13LkO5OlMyKM7:TR?= MmL1V2FPT0WU
NCI-H1882 MkXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnL0TWM2OD13LkSzN|Y1KM7:TR?= MXTTRW5ITVJ?
SNU-475 MojjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\5SpRsUUN3ME21MlQ4OTdzIN88US=> NEfu[29USU6JRWK=
RXF393 NEfWem9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XITGlEPTB;NT60PFQ6PCEQvF2= Mn3ZV2FPT0WU
CAL-51 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXCToV6UUN3ME21MlYzQDV|IN88US=> MorHV2FPT0WU
SW1573 MkLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTYRlJiUUN3ME21MlY{PTN2IN88US=> M1fN[HNCVkeHUh?=
GCT NX6yb3A5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGL2fmtKSzVyPUWuO|U6OjlizszN NV6yWlVvW0GQR1XS
COR-L88 NH6wfotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DGcGlEPTB;NT63Olg1PiEQvF2= NXe4VJN4W0GQR1XS
MDA-MB-134-VI NWTWdWtzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlv2TWM2OD13Lki3OVM3KM7:TR?= NUnKeZdrW0GQR1XS
NB5 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkH2TWM2OD13LkmyOFQh|ryP M3\DenNCVkeHUh?=
GMS-10 NFnpVYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLIPGVKSzVyPUWuPVY5PjFizszN NEXYOo9USU6JRWK=
CHP-212 NUTXdGxVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfjbXBKSzVyPU[uOFgzPjdizszN M1zJc3NCVkeHUh?=
TE-11 M2H4bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;vTWM2OD14LkW1NVgzKM7:TR?= NWPMOGN1W0GQR1XS
SW962 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jPNGlEPTB;Nj62OVc4PCEQvF2= MWPTRW5ITVJ?
MZ2-MEL M{WyTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTZwOEKwNVEh|ryP NF\wSYdUSU6JRWK=
C-33-A NFPNT|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfRXoxUUUN3ME22MlkyPjh6IN88US=> MV;TRW5ITVJ?
IGR-1 NHLkRVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTZwOUe4NlYh|ryP MYfTRW5ITVJ?
MOLT-4 Ml6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\MTWM2OD15LkG1OFA3KM7:TR?= NEHHZm1USU6JRWK=
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FADU NW\6RWZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3KxbmlEPTB;NEiuN|A{OSEQvF2= Mn;YV2FPT0WU
S-117 NVu0NJExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLXZYlTUUN3ME20PE4{QDF3IN88US=> NV\ET3ZiW0GQR1XS
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CAMA-1 M2nRO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XISWlEPTB;NEmuOVU1OyEQvF2= NVL2ZoNWW0GQR1XS
LU-134-A M3XTc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljPTWM2OD12OT64NFg2KM7:TR?= NEnwTZpUSU6JRWK=
NCI-H1838 M1uxdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;vUVJJUUN3ME20PU45ODh5IN88US=> MmnVV2FPT0WU

... Click to View More Cell Line Experimental Data
体内研究 Ponatinib抑制取自FLT3-ITD阳性AML病人的原代白血病细胞，而不抑制表达阴性FLT3的AML病人的白血病细胞。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验：[1]
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激酶实验:

通过同质时间分辨荧光共振能量转移法(TR-FRET)，使用纯化的人类野生型ABL激酶，T315I突变型ABL激酶，及生物素化的磷酸激酶底物肽: 生物素-EKKMAAEAIYAAPFAK-NH2，测定野生型ABL和T315I突变型ABL活性的抑制激酶反应在全LANCE激酶buffer (LKB)中进行，LKB包括20 mM NaHEPES（pH 为7.4）, 0.1 mg ⁄ mL BSA, 1 mM ATP, 10 mM MgCl2, 及0.41 mM DTT，在提前用1% BSA（溶于PBS）包被的96孔板上4oC下过夜。用于激酶反应，Ponatinib稀释物和野生型ABL, T315I突变型ABL (40 pM), 及底物肽(50 nM), 在室温下温育1小时（T315I突变型ABL）或2小时（野生型ABL）。加入15 nM 抑制剂, 6 nM 铕标记的磷酸酪氨酸抗体（磷酸化位点在第66为酪氨酸上），及60 nM 别藻蓝素标记的链酶亲和素，终止反应。实验板在室温下黑暗温育20分钟，使用Wallac Victor2V读数器读取615和665nm处的荧光值。在孔中数据平均值中插入抑制剂的3倍连续稀释液，再读取665nm处荧光值，计算IC50值。
细胞实验：[1]
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  • Cell lines: Ba ⁄ F3细胞
  • Concentrations: 0-625 nM, 和0-10 µM
  • Incubation Time: 72小时
  • Method: Ba/F3细胞系按每孔4×103个细胞分布在96孔板上(4×103)，和梯度浓度Ponatinib温育72小时。Ponatinib浓度范围为: 0-625 nM 作用于表达BCR-ABL细胞，0-10 µM 用于测定BCR-ABL阴性细胞。使用MTS实验测定细胞增殖，取三次平行实验平均值测定IC50值。
    (Only for Reference)
动物实验：[3]
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  • Animal Models: 皮下植入MV4-11细胞移植瘤(1×107，50%基质胶中) 的雌性CB.17 SCID鼠
  • Formulation: 25 mmol/L柠檬酸盐缓冲液(pH 为2.75)
  • Dosages: 每天处理一次，持续4周
  • Administration: 口服饲喂处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)：
1% CMC Na 		30mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 532.56
化学式

C29H27F3N6O
CAS号 943319-70-8
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量：

总分子量：g/mol

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03838692 Not yet recruiting Medullary Thyroid Cancer Antonio Fojo|Millennium Pharmaceuticals Inc.|Columbia University April 2019 Phase 2
NCT03838692 Not yet recruiting Medullary Thyroid Cancer Antonio Fojo|Millennium Pharmaceuticals Inc.|Columbia University April 2019 Phase 2
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03807479 Recruiting Leukemia Myeloid Chronic-Phase GWT-TUD GmbH|Incyte Biosciences International Sàrl December 11 2018 Phase 2
NCT03807479 Recruiting Leukemia Myeloid Chronic-Phase GWT-TUD GmbH|Incyte Biosciences International Sàrl December 11 2018 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1：

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答：

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

Selleck产品目录册

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

  • 选择性强的Bcr-Abl抑制剂

    Nilotinib (AMN-107) : Bcr-Abl-selective, IC50<30 nM.

  • 活性最高的Bcr-Abl抑制剂

    GZD824 : Bcr-Abl(WT), IC50=0.34 nM; Bcr-Abl(T315I), IC50=0.68 nM.

  • FDA批准的Bcr-Abl抑制剂

    Dasatinib : Approved by FDA for CML and Ph+ ALL.

  • 最新的Bcr-Abl抑制剂

    GZD824 : Orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

相关Bcr-Abl产品

  • PX-478 2HCl New

    PX-478 2HCl是一种具有口服活性的选择性hypoxia-inducible factor-1α (HIF-1α)抑制剂。Phase 1。

  • Defactinib (VS-6063, PF-04554878) New

    Defactinib (VS-6063, PF-04554878)是一种选择性，且口服有效的FAK抑制剂。Phase 2。

  • SU6656 New

    SU 6656 是一种选择性 Src 家族激酶抑制剂，对Src，Yes，Lyn，和 Fyn 的 IC50 分别为 280 nM，20 nM，130 nM，和 170 nM。

  • Imatinib Mesylate (STI571)

    Imatinib Mesylate (STI571)是一种口服生物有效的Imatinib甲磺酸盐，是一种多靶点抑制剂，作用于v-Abl，c-Kit和PDGFR，在无细胞和细胞试验中，IC50分别为0.6 μM，0.1 μM 和0.1 μM。

  • Nilotinib (AMN-107)

    Nilotinib (AMN-107)是一种特异性BCR-ABL抑制剂，在小鼠骨髓祖细胞中IC50低于30 nM。

    Features:Nilotinib 是Abl选择性抑制剂，与BCR-ABL的ATP结合位点相互作用。

  • Bafetinib (INNO-406)

    Bafetinib (INNO-406)是一种有效的，选择性的，双重Bcr-Abl/Lyn双重抑制剂，无细胞试验中IC50为5.8 nM/19 nM，对T315I突变型的磷酸化没有抑制作用，对PDGFR和c-Kit的作用效果较弱。Phase 2。

    Features:Bafetinib是有效的双重Bcr-Abl/Lyn酪氨酸激酶选择性抑制剂。

  • Degrasyn (WP1130)

    Degrasyn (WP1130)是一种选择性deubiquitinase (DUB: USP5，UCH-L1，USP9x，USP14，和 UCH37)抑制剂，对Bcr/Abl也有抑制作用，也是一种JAK2传感器(不影响20S蛋白酶体)和转录激活剂(STAT)。

    Features:WP1130 has an advantage over imatinib mesylate in that its activity is not inhibited by a variety of Abl kinase mutations, including T315I.

  • Rebastinib (DCC-2036)

    Rebastinib (DCC-2036)是一种Bcr-Abl抑制剂，作用于Abl1(WT)和Abl1(T315I)，IC50分别为0.8 nM和4 nM，也抑制SRC， LYN， FGR， HCK， KDR， FLT3，和Tie-2，对c-Kit具有低的抑制活性。Phase 1。

  • GZD824 Dimesylate(HQP1351)

    GZD824 Dimesylate是新型口服有效的Bcr-Abl抑制剂，作用于Bcr-Abl(WT)和Bcr-Abl(T315I)，IC50分别为0.34 nM和0.68 nM。

  • GNF-2

    GNF-2是一种高选择性，非ATP竞争性的Bcr-Abl抑制剂，对Flt3-ITD， Tel-PDGFR， TPR-MET和Tel-JAK1转化的肿瘤细胞没有作用活性。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID