Ponatinib (AP24534)

For research use only. Not for use in humans.

目录号:S1490

Ponatinib (AP24534) Chemical Structure

CAS No. 943319-70-8

Ponatinib (AP24534)是一种新型有效的多靶点抑制剂,在无细胞试验中作用于Abl,PDGFRα,VEGFR2,FGFR1和Src,IC50分别为0.37 nM,1.1 nM,1.5 nM,2.2 nM和5.4 nM。Ponatinib (AP24534)可抑制自噬。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 819.31 现货
RMB 903.01 现货
RMB 3034.48 现货
RMB 7959.08 现货
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客户使用Selleck生产的Ponatinib (AP24534)发表文献101篇:

产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

产品描述 Ponatinib (AP24534)是一种新型有效的多靶点抑制剂,在无细胞试验中作用于Abl,PDGFRα,VEGFR2,FGFR1和Src,IC50分别为0.37 nM,1.1 nM,1.5 nM,2.2 nM和5.4 nM。Ponatinib (AP24534)可抑制自噬。
靶点
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外研究

Ponatinib是有效的可用于口服的多靶点激酶抑制剂,作用于野生型细胞,及T315I 突变细胞IC50分别为1.2和8.8nM。[1] Ponatinib抑制Ba/F3衍生细胞系的增殖。[2] Ponatinib作用于表达野生型或T315I突变型BCR-ABL的CML细胞系,有效抑制BCR-ABL调节的信号。Ponatinib阻断在细胞瘤筛选时产生抗性突变。[3] Ponatinib也抑制VEGFR和FGFR家族激酶,在体外抑制FLT3, KIT, FGFR1,和PDGFRa激酶活性时IC50分别为13, 13, 2, 和1 nM.[4]Ponatinib抑制全部4种RTKs磷酸化,存在剂量依赖性,IC50值为0.3到20 nM。然而,Ponatinib抑制表达野生型FLT3的RS4;11细胞时IC50>100 nM。

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell M4P2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTVNZAzUUN3ME2wMlAxODByMECzOVkh|ryP MXHTRW5ITVJ?
MV-4-11 M4LWe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMECwNFk2PiEQvF2= MofpV2FPT0WU
MEG-01 NYjZWFBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWf3NGdWUUN3ME2wMlAxODF{ODFOwG0> MnXEV2FPT0WU
LAMA-84 Ml;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfSRVdKSzVyPUCuNFAxOTZ3IN88US=> NHL4[41USU6JRWK=
CGTH-W-1 M3[3XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMECxOlkh|ryP NFPN[oxUSU6JRWK=
KASUMI-1 M3;N[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33OOGlEPTB;MD6wNFIyPyEQvF2= MlHqV2FPT0WU
BE-13 M4\SUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMECyOVkh|ryP NUCxeplmW0GQR1XS
CTV-1 M3uxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\1XFVKSzVyPUCuNFA2OjFizszN MkTGV2FPT0WU
NKM-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMEC2OVUh|ryP M3jCRnNCVkeHUh?=
MONO-MAC-6 NUHVdFhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3B[|JLUUN3ME2wMlAxQDN5IN88US=> MVzTRW5ITVJ?
A204 NFTodXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDUVYp3UUN3ME2wMlAyOjF6IN88US=> MorXV2FPT0WU
GDM-1 M3ixWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwMEG4N|Mh|ryP M{fPXXNCVkeHUh?=
AN3-CA MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnT6TWM2OD1yLkCxPFc{KM7:TR?= Mn7jV2FPT0WU
BL-70 NXrxbHBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGP3cXpKSzVyPUCuNFIyQTlizszN MnWzV2FPT0WU
Daudi MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnH2TWM2OD1yLkCyOVM4KM7:TR?= M{n3cHNCVkeHUh?=
KU812 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;PS49KSzVyPUCuNFI5PDhizszN MWXTRW5ITVJ?
KG-1 NX65RVEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDBU|NKSzVyPUCuNFMzQTRizszN MlzGV2FPT0WU
DOHH-2 NH3y[YpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TwUmlEPTB;MD6wOFgxOyEQvF2= MULTRW5ITVJ?
HuO9 NELW[ZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfLTGNKSzVyPUCuNFU1PDhizszN NVrJfIc5W0GQR1XS
EB2 NU\zNpJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nkVWlEPTB;MD6wOVU4PiEQvF2= Mn:2V2FPT0WU
G-402 MlHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYmwV2JOUUN3ME2wMlA3OzRzIN88US=> M{DFW3NCVkeHUh?=
SU-DHL-1 M2\5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfYTWM2OD1yLkC2N|c6KM7:TR?= MYrTRW5ITVJ?
NCI-H719 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLyTWM2OD1yLkC3PFg5KM7:TR?= M2rDR3NCVkeHUh?=
MLMA NUfFRnBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYOzO|dsUUN3ME2wMlA6ODZizszN MVjTRW5ITVJ?
KM12 NFi5WWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLyTWM2OD1yLkC5O|M4KM7:TR?= MY\TRW5ITVJ?
SUP-T1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMEm5PFIh|ryP M{fGUnNCVkeHUh?=
MZ1-PC NX3BdoxyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojaTWM2OD1yLkGxN|M3KM7:TR?= MmS1V2FPT0WU
MFE-296 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLETWM2OD1yLkGxPFM6KM7:TR?= NUnM[|N6W0GQR1XS
ALL-PO MoPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXOWYxKSzVyPUCuNVI1PDNizszN NYjVcIhqW0GQR1XS
GB-1 MnrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjRTWM2OD1yLkGyOVEzKM7:TR?= NWKyUI5HW0GQR1XS
SIG-M5 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknYTWM2OD1yLkGzN|ch|ryP NWPheXExW0GQR1XS
P30-OHK NVfkcI9CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFW0OYhKSzVyPUCuNVU3PzJizszN M4K4VXNCVkeHUh?=
NCI-H716 MonyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjHemgyUUN3ME2wMlE3OjZ4IN88US=> NFzqfXNUSU6JRWK=
MPP-89 M1znN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMU[5N|Mh|ryP NF3YSWFUSU6JRWK=
SF126 NWG0bGxHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoH4TWM2OD1yLkG3NFY{KM7:TR?= MXHTRW5ITVJ?
CTB-1 NF:zSlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfvZm9KUUN3ME2wMlE4OzF4IN88US=> NWXaUHJiW0GQR1XS
CA46 M{HrSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTHTWM2OD1yLkG3OFg6KM7:TR?= NEnC[HZUSU6JRWK=
NCI-H520 NGfoeIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;EbnR3UUN3ME2wMlE4PzN{IN88US=> Ml7kV2FPT0WU
CAL-85-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPkTWM2OD1yLkG3PVI4KM7:TR?= NGnMSm9USU6JRWK=
NCI-H2342 M4jJSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMUi1O|ch|ryP NF\oPZpUSU6JRWK=
697 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\pTWM2OD1yLkG4PFcyKM7:TR?= MnTSV2FPT0WU
NY M1\wUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMUmyPFch|ryP MonJV2FPT0WU
T98G Ml7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4T3UGlEPTB;MD6xPVMyQCEQvF2= NUe0WFlzW0GQR1XS
NCI-H1703 NH;sS2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjH[WlVUUN3ME2wMlE6PjF3IN88US=> M36xNHNCVkeHUh?=
NCI-H2087 NIryUWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPDbIw6UUN3ME2wMlIxPDN7IN88US=> NWTGSYt{W0GQR1XS
PF-382 MnTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHq4SnZKSzVyPUCuNlA5PzNizszN NIP1dnJUSU6JRWK=
HCT-116 MnzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3CfXBPUUN3ME2wMlIyODZ7IN88US=> MUHTRW5ITVJ?
CAKI-1 MmDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4X2[WlEPTB;MD6yNVY3PiEQvF2= NH6xNmRUSU6JRWK=
CCF-STTG1 M3r1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XhSWlEPTB;MD6yNlQ4PSEQvF2= M4fCc3NCVkeHUh?=
D-392MG Mn\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFv2PIFKSzVyPUCuNlMyPzdizszN M1f2fXNCVkeHUh?=
RT-112 NUjGRZhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPhN2VXUUN3ME2wMlI{Pzl3IN88US=> M4W3dXNCVkeHUh?=
MES-SA M3HFUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTUTm9FUUN3ME2wMlI1OTh5IN88US=> NHi2dpNUSU6JRWK=
LC-2-ad MlHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjmXpJKSzVyPUCuNlQzPjVizszN MXnTRW5ITVJ?
NOS-1 M{fKNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPwZ4Q1UUN3ME2wMlI1OzZ5IN88US=> MkDjV2FPT0WU
NALM-6 MoTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLJdJJtUUN3ME2wMlI2PTR|IN88US=> M4LkenNCVkeHUh?=
TE-15 NXrKTI5mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMk[wPVEh|ryP MVTTRW5ITVJ?
786-0 NX\yUHFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DFSGlEPTB;MD6yOlIzQCEQvF2= M2TGXnNCVkeHUh?=
IST-MES1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\2eXVKSzVyPUCuNlY5OjlizszN NEGx[3JUSU6JRWK=
KYSE-180 NHT1dG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HwUmlEPTB;MD6yOlg6OSEQvF2= NGW1VG5USU6JRWK=
YT NYPqOWp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDzOYdSUUN3ME2wMlI3QTd2IN88US=> MUTTRW5ITVJ?
A427 NYC3fXJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1L4emlEPTB;MD6yO|I3PCEQvF2= MlvrV2FPT0WU
KYSE-450 NHruNopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX0[2pVUUN3ME2wMlI4OzJ7IN88US=> NUXMXm9sW0GQR1XS
HuH-7 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV36UZBqUUN3ME2wMlI4PzZ|IN88US=> NIDQfIVUSU6JRWK=
CAS-1 M4LMXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEiwd4RKSzVyPUCuNlg{ODNizszN MVPTRW5ITVJ?
KURAMOCHI Moq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTtZYhMUUN3ME2wMlI5PDF7IN88US=> MUTTRW5ITVJ?
ACHN NGrudotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvwTWM2OD1yLkK5N|I{KM7:TR?= NGP3SoVUSU6JRWK=
HGC-27 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMkmzOVMh|ryP MVnTRW5ITVJ?
A172 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMkm1O|ch|ryP NH\EZodUSU6JRWK=
SNU-449 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjWe2ZKSzVyPUCuNlk6PjRizszN M4DXT3NCVkeHUh?=
SW982 NIPib4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDPTWM2OD1yLkK5PVc5KM7:TR?= M2O1SnNCVkeHUh?=
EFO-21 NYXEfFd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHroTlJKSzVyPUCuN|A1OTFizszN NX3uNZcxW0GQR1XS
NCI-H2030 M1rNNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwM{GxOlQh|ryP NELiVotUSU6JRWK=
HT-144 M1vzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXCOoduUUN3ME2wMlMyOjhizszN MlL1V2FPT0WU
MFE-280 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnaTGhsUUN3ME2wMlMyPDV|IN88US=> NILscYdUSU6JRWK=
SK-LU-1 NFr2c4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXWe5VKSzVyPUCuN|E1PjZizszN NEXRdY9USU6JRWK=
NCI-H2052 NIrOUWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfwTWM2OD1yLkOxOFg1KM7:TR?= M3PSO3NCVkeHUh?=
SK-HEP-1 Ml\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwM{OzOlgh|ryP MYXTRW5ITVJ?
QIMR-WIL NW\iXYxFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDRfGpKSzVyPUCuN|M1OjRizszN Ml;6V2FPT0WU
A2780 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDub29KSzVyPUCuN|Q{ODRizszN MkLCV2FPT0WU
ACN M3nGUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml[yTWM2OD1yLkO0PFc{KM7:TR?= NFnWVW5USU6JRWK=
BxPC-3 MlTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwM{S5PFkh|ryP MVvTRW5ITVJ?
BCPAP M2HaOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwM{[wNFEh|ryP M2[xfnNCVkeHUh?=
HOP-62 Ml\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXCc2xIUUN3ME2wMlM3OTB4IN88US=> MUTTRW5ITVJ?
SW1710 NHrScnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwM{[0OVUh|ryP MYTTRW5ITVJ?
OPM-2 MmHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnyUohKSzVyPUCuN|Y1PzNizszN NXzhfm1CW0GQR1XS
DBTRG-05MG NEmydItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILN[3ZKSzVyPUCuN|gxPTRizszN NET2cXBUSU6JRWK=
SK-MEL-24 NYqyfHN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnaZoNKSzVyPUCuN|k4QTFizszN NEjRXItUSU6JRWK=
8305C M1jNVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{P6fmlEPTB;MD6zPVc6OyEQvF2= MXTTRW5ITVJ?
OVCAR-4 M2GybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnleFBCUUN3ME2wMlQyPTh4IN88US=> M3fPS3NCVkeHUh?=
HLE MlHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrtWZR[UUN3ME2wMlQyQDZizszN NFSyeGNUSU6JRWK=
NCI-H747 NEXiOXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwNEKxN|ch|ryP MWDTRW5ITVJ?
SW780 NXG1cop2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2ntUmlEPTB;MD60NlM1PiEQvF2= M3;s[3NCVkeHUh?=
KYSE-150 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkniTWM2OD1yLkSyOFE2KM7:TR?= NEXSU2RUSU6JRWK=
H4 M{X2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3hWFRKSzVyPUCuOFI1PTFizszN NVLNW495W0GQR1XS
SW1088 NY\HSld5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwNESzPUDPxE1? M3jDS3NCVkeHUh?=
SF268 Ml\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXDTWM2OD1yLkS0PFYh|ryP NXTueW1pW0GQR1XS
RT4 NGj2PHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHaTWM2OD1yLkS1NVEyKM7:TR?= NX7XRVh4W0GQR1XS
NCI-H522 NWnGc3hzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwNEWyO{DPxE1? M3XLS3NCVkeHUh?=
LCLC-97TM1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vIR2lEPTB;MD60OlE6PSEQvF2= MnjoV2FPT0WU
CAL-39 M3zSe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fRVGlEPTB;MD60OlUyQSEQvF2= NICxZ2JUSU6JRWK=
CAL-120 MljKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rNbmlEPTB;MD60O|Y1OyEQvF2= NHHSS|NUSU6JRWK=
ESS-1 NFfwTmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jzU2lEPTB;MD60O|gzOSEQvF2= M1zXNXNCVkeHUh?=
KARPAS-45 NV;BfIp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NED3cVJKSzVyPUCuOFg6OzNizszN NEDDO4hUSU6JRWK=
DU-4475 Ml7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwNEm1NVEh|ryP NVy1NVVRW0GQR1XS
VMRC-RCZ NYLqeHZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLYU|FKSzVyPUCuOFk6ODRizszN MmDEV2FPT0WU
HOS MoGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\0WZZKSzVyPUCuOVA{PjVizszN MlrDV2FPT0WU
MOLT-16 M4T6Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;3SFVKSzVyPUCuOVE5ODhizszN MXPTRW5ITVJ?
RPMI-6666 MlXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwNUKxN|Uh|ryP NELKPXZUSU6JRWK=
K052 NHvx[4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1raSmlEPTB;MD61NlE1KM7:TR?= M1HUN3NCVkeHUh?=
EHEB MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\kTWM2OD1yLkWyNVgzKM7:TR?= NX\Pb3JUW0GQR1XS
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NCI-H1581 NIrjZY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwOEmyPVch|ryP MkP0V2FPT0WU
HuCCT1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\uT4VPUUN3ME2wMlg6PTR6IN88US=> NFy3XoRUSU6JRWK=
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HL-60 M{XXdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmL3TWM2OD1zLkCwPVch|ryP Mne4V2FPT0WU
HDLM-2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fTRmlEPTB;MT6wNVI2OiEQvF2= NUfwVI9IW0GQR1XS
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CAL-54 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTFwMEO5OVkh|ryP M33Bb3NCVkeHUh?=
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U-266 MkmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonUTWM2OD1zLkC5OlM{KM7:TR?= MnfNV2FPT0WU
HT-1197 NUHPNHZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfE[nFqUUN3ME2xMlEyPDN6IN88US=> NIPFUpFUSU6JRWK=
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MHH-NB-11 M1rW[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4H5W2lEPTB;MT6xOVM3QCEQvF2= MmfrV2FPT0WU
NCI-H2405 NIfvb|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DpemlEPTB;MT6xOlE3KM7:TR?= MYHTRW5ITVJ?
COLO-668 NWfZdZUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XLeGlEPTB;MT6xOlQ6KM7:TR?= MXXTRW5ITVJ?
IMR-5 MlywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPTW4ZKSzVyPUGuNVY6OzZizszN MmXFV2FPT0WU
ARH-77 M{XPPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3SXm5XUUN3ME2xMlIzQTJ2IN88US=> MUDTRW5ITVJ?
BHT-101 M4OwS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTFwMkO0PUDPxE1? NVftTpJ7W0GQR1XS
SCC-25 MnvxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTFwMkO1N|Yh|ryP MlvSV2FPT0WU
NTERA-S-cl-D1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2qzNmlEPTB;MT6yOFM1PiEQvF2= MljFV2FPT0WU
MKN28 M4OzU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEH2RY9KSzVyPUGuNlU3OzZizszN MnTiV2FPT0WU
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NCI-H1734 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;mTWM2OD1zLkK4PVE{KM7:TR?= NFy0TJlUSU6JRWK=
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NCI-H838 M3zPWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvBTWM2OD1zLkOwOlE2KM7:TR?= NHLOd3FUSU6JRWK=
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ME-180 NHrXTndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTRTWM2OD1zLkO3PVk{KM7:TR?= M4fjfnNCVkeHUh?=
MMAC-SF Mn7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvNNlh4UUN3ME2xMlM6PTl3IN88US=> Mm[zV2FPT0WU
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MN-60 MmHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFmxclZKSzVyPUGuOFMyOTRizszN MXXTRW5ITVJ?
SIMA NYW0[G42T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrh[3dKSzVyPUGuOFg3QDdizszN M3rqUXNCVkeHUh?=
NCI-H1770 NX;zVG43T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXETWM2OD1zLkWyNFU1KM7:TR?= M1LRPXNCVkeHUh?=
ONS-76 M4Hie2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moi2TWM2OD1zLkWyN|EyKM7:TR?= M4HuNXNCVkeHUh?=
LB771-HNC MkLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjiTGJvUUN3ME2xMlU{QTB4IN88US=> M3zKZXNCVkeHUh?=
SW48 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTFwNUSyOFMh|ryP NGO2bnJUSU6JRWK=
KYSE-140 NFSxd|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[2W2lEPTB;MT61OVc1OSEQvF2= MVTTRW5ITVJ?
SW626 NF;OPGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHKTVdKSzVyPUGuOVgyPiEQvF2= NFr4dG5USU6JRWK=
MC-CAR M2fWVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHJTWM2OD1zLkW4OlY{KM7:TR?= MWrTRW5ITVJ?
D-336MG MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zadGlEPTB;MT62Nlk1KM7:TR?= Mni4V2FPT0WU
SK-MEL-3 NGjiSFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkD6TWM2OD1zLk[zPVAzKM7:TR?= MUTTRW5ITVJ?
MHH-PREB-1 NILrTppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3q3[GlEPTB;MT62OFQ4OyEQvF2= NWfsO4ZvW0GQR1XS
Calu-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHke3JKSzVyPUGuOlU{QDZizszN NFfHNpdUSU6JRWK=
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A101D NELGOVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XoUGlEPTB;MT62Olc5OSEQvF2= MmrlV2FPT0WU
A704 M{Hob2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFn4N2ZKSzVyPUGuOlg{OTFizszN MnLFV2FPT0WU
LB831-BLC M3myZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;mU2lEPTB;MT62PVg2PCEQvF2= M{KwSHNCVkeHUh?=
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RPMI-2650 NFHhfFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkntTWM2OD1zLkeyO|E6KM7:TR?= NWTDfYpKW0GQR1XS
NH-12 MmrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTFwN{O0Nlch|ryP M2XH[XNCVkeHUh?=
AGS M3LIPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHYTWM2OD1zLke2N|U5KM7:TR?= MWfTRW5ITVJ?
NEC8 M2n1NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTFwN{i5PVUh|ryP MWHTRW5ITVJ?
NCI-H2009 MlT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTFwN{m3NlEh|ryP MlPYV2FPT0WU
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NCI-H810 NGjCZpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFX0T|NKSzVyPUGuPFE3ODZizszN M3X5NXNCVkeHUh?=
SK-NEP-1 M{LBTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrFTWM2OD1zLkizO|Y4KM7:TR?= NVjI[Fk4W0GQR1XS
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OVCAR-5 MoDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XTSmlEPTB;MT65NFY4PSEQvF2= NE\ZR5RUSU6JRWK=
SNG-M NGnhbHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmW4TWM2OD1zLkm1PFU5KM7:TR?= NVzq[3pjW0GQR1XS
A673 NWfH[JJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vhdGlEPTB;MT65O|UyPiEQvF2= MX3TRW5ITVJ?
L-428 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFK0bY5KSzVyPUGuPVkyPzlizszN MVPTRW5ITVJ?
KM-H2 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF:zW3VKSzVyPUKuNFExQSEQvF2= MXXTRW5ITVJ?
MC-IXC MnHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTJwMEKyO|Mh|ryP M1\rTnNCVkeHUh?=
COLO-678 NInjU|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnBTWM2OD1{LkC0NlA4KM7:TR?= NYC0S5hYW0GQR1XS
MEL-JUSO NXfNNnlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjubWxKSzVyPUKuNFc5PTFizszN NV2z[nBwW0GQR1XS
HCC38 MkjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTJwMEi0N|Mh|ryP M1K0NHNCVkeHUh?=
UACC-62 NEPKXYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HMdWlEPTB;Mj6wPFg2PSEQvF2= MVjTRW5ITVJ?
OAW-42 M4\pZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWewNlE4UUN3ME2yMlA6PzFzIN88US=> MmX3V2FPT0WU
LB996-RCC Ml7SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzRS4N7UUN3ME2yMlE{QDF5IN88US=> M2PzV3NCVkeHUh?=
COR-L105 M4K0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PSUWlEPTB;Mj6xOlM4OyEQvF2= NE\hc3RUSU6JRWK=
RCC10RGB NEDwcJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWWyVZgxUUN3ME2yMlE5PTd4IN88US=> NV3wNIhFW0GQR1XS
A431 MkPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYH0T2V2UUN3ME2yMlE6ODF7IN88US=> NWHIRm1mW0GQR1XS
NCI-H292 NVX0[2ZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3RW2hKSzVyPUKuNlM6PTFizszN NVzNNGNMW0GQR1XS
SK-UT-1 NUPTT4dJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTJwM{OxPFQh|ryP NIG5cHBUSU6JRWK=
PANC-08-13 NHPGU|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmWyTWM2OD1{LkOzNlM2KM7:TR?= NVzicZp5W0GQR1XS
ST486 NGOxd3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Lye2lEPTB;Mj60NVA1QCEQvF2= MnvDV2FPT0WU
SJSA-1 M4PwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13kWGlEPTB;Mj60NVI4OSEQvF2= NF;4d3NUSU6JRWK=
RKO MlTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jH[mlEPTB;Mj60NlAzQSEQvF2= NUfYOZFwW0GQR1XS
NCI-H1793 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LRfGlEPTB;Mj60OFAzQSEQvF2= MmPZV2FPT0WU
639-V M3z5e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTJwNEWzPFIh|ryP NVX2cZV5W0GQR1XS
ES3 Mme4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LmUWlEPTB;Mj60PVc{PyEQvF2= MnXUV2FPT0WU
NCI-H1792 NXzNVmZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\KeWlEPTB;Mj61OlgzPiEQvF2= NGP5SY1USU6JRWK=
NCI-H1651 NHz1TZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLseIJ7UUN3ME2yMlU5OjFizszN M2e1enNCVkeHUh?=
SN12C NXTMW4ZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3ZTWM2OD1{LkW4OFg4KM7:TR?= M{fmbHNCVkeHUh?=
COLO-679 MnfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HWSGlEPTB;Mj61PFYxPSEQvF2= NGXEZVJUSU6JRWK=
U-118-MG NUjUfJZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvnO283UUN3ME2yMlU5QDd{IN88US=> MXXTRW5ITVJ?
Ramos-2G6-4C10 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnkdmo2UUN3ME2yMlY1QDB5IN88US=> M2P1UXNCVkeHUh?=
HCT-15 Mo\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH35SndKSzVyPUKuOlg4QTJizszN NGr4[YFUSU6JRWK=
MDA-MB-157 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEW4TlFKSzVyPUKuO|A4PDdizszN NE\5S2lUSU6JRWK=
K5 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fWUWlEPTB;Mj63NVg1PSEQvF2= MmrxV2FPT0WU
MKN45 M{HKcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTJwN{OzOlYh|ryP NUH6[ZpxW0GQR1XS
DMS-273 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTLTWM2OD1{Lke1OlMzKM7:TR?= Mki0V2FPT0WU
C8166 M3TS[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nRR2lEPTB;Mj63PFUyOyEQvF2= MkjwV2FPT0WU
Calu-3 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTSc2lxUUN3ME2yMlc5QTZ7IN88US=> NIq0U3RUSU6JRWK=
SNB75 MnHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzkTIxjUUN3ME2yMlg5PTN3IN88US=> Mm\RV2FPT0WU
BFTC-905 NW[2bVJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTxTWM2OD1{LkmwNVkyKM7:TR?= NH\QV|JUSU6JRWK=
C-4-II M3PZUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXJeFVKSzVyPUKuPVE{PTNizszN MXHTRW5ITVJ?
MS-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPVTWM2OD1{Lkm2O|Y6KM7:TR?= MnLEV2FPT0WU
A375 M17Pb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3juOGlEPTB;Mz6wPFE5PCEQvF2= NIjn[2JUSU6JRWK=
KYSE-70 NY\JTW86T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvlTWM2OD1|LkC4PFgzKM7:TR?= NWjFT3JFW0GQR1XS
KYSE-510 NVm3WHJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXL6b49jUUN3ME2zMlExQTl3IN88US=> NVTpNIJoW0GQR1XS
LN-405 NFPaPXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki3TWM2OD1|LkGzOVE5KM7:TR?= MYnTRW5ITVJ?
BOKU MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXlWox4UUN3ME2zMlE1OjV4IN88US=> M2jXNXNCVkeHUh?=
TE-10 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUL3OZNbUUN3ME2zMlE4OzZ{IN88US=> NIW2PVJUSU6JRWK=
MKN1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHlSYlqUUN3ME2zMlE5PDh|IN88US=> MlrJV2FPT0WU
M059J NGfGcGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrO[HNKSzVyPUOuNlAyPzNizszN NYL5bHpIW0GQR1XS
GOTO NHG0bIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fkNmlEPTB;Mz6yNlA{QSEQvF2= M2j1VnNCVkeHUh?=
DK-MG M2HRTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfPTWM2OD1|LkK1PVc3KM7:TR?= NEDhW2tUSU6JRWK=
NCI-H727 NXjjd5pMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDHTWM2OD1|LkK2OVgh|ryP MmXLV2FPT0WU
NB12 NFvwZVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfDTnFGUUN3ME2zMlM{OjJ2IN88US=> M1\4[XNCVkeHUh?=
DOK MmqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3u0[mlEPTB;Mz6zOlE5PiEQvF2= NXTqXmN4W0GQR1XS
KYSE-410 MlPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\mTWM2OD1|LkO2Nlg4KM7:TR?= NYW0XFl2W0GQR1XS
AM-38 Mn;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkH1TWM2OD1|LkO4NFUyKM7:TR?= M1jCZXNCVkeHUh?=
GR-ST NGrGTmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPiXWpKSzVyPUOuOFU4OzJizszN MUTTRW5ITVJ?
D-247MG NXXqR5RkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVmzO4hbUUN3ME2zMlQ5OjZ|IN88US=> NEnvPXNUSU6JRWK=
TE-8 M3:3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\hfGlEPTB;Mz60PVM{OyEQvF2= M{DzNXNCVkeHUh?=
LS-411N MmfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXZTWM2OD1|LkS5OlkzKM7:TR?= M{SxZnNCVkeHUh?=
SK-MES-1 NFXmWY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrVPIo4UUN3ME2zMlU3PDN|IN88US=> NXj1NoFWW0GQR1XS
SF295 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTNwNkG1OVIh|ryP MmPsV2FPT0WU
SK-MEL-30 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTNwNkW5NlEh|ryP Mnj0V2FPT0WU
LB2241-RCC Mm\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DFcWlEPTB;Mz62OlI3KM7:TR?= MXjTRW5ITVJ?
PC-14 NHqwSXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTNwNk[0N|ch|ryP MljSV2FPT0WU
EW-7 NWfSNJBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLaTWM2OD1|Lk[3Olk{KM7:TR?= NW\4O2xiW0GQR1XS
NMC-G1 NFrrVlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\TTWM2OD1|LkexPFM4KM7:TR?= MWXTRW5ITVJ?
TE-441-T NG\lepNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3sO5JKSzVyPUOuO|MxOjhizszN NFnXW|BUSU6JRWK=
NCI-H1618 M2HzXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVz1UVFzUUN3ME2zMlgyQDd3IN88US=> NVHUbIt5W0GQR1XS
PANC-03-27 MmT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjZTWM2OD1|LkixPVE3KM7:TR?= MUPTRW5ITVJ?
NCI-H2228 NIPzbmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvOUmpKSzVyPUOuPFMyOjZizszN MYfTRW5ITVJ?
CAPAN-1 NYTaXFQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTNwOEewNFkh|ryP M1vrcXNCVkeHUh?=
KLE M3f5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTNwOUC2O{DPxE1? MX3TRW5ITVJ?
Becker MkLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXoTWM2OD1|LkmyPFQ6KM7:TR?= MXnTRW5ITVJ?
SK-PN-DW M3rDbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2X0OWlEPTB;ND6wO|k4PCEQvF2= NH7vTmtUSU6JRWK=
Hs-578-T NFzkOoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnn6TWM2OD12LkC4N|A3KM7:TR?= NVfVbVVoW0GQR1XS
RS4-11 NGPBUZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfHTWM2OD12LkGxNlU2KM7:TR?= M130OnNCVkeHUh?=
D-502MG M1j4VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvoNm1KSzVyPUSuNVY6QTdizszN M4foTXNCVkeHUh?=
GI-1 NIXRZXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfZPG5KSzVyPUSuNlgzQTlizszN NHOwfFlUSU6JRWK=
NCI-H209 MnTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTuR2ZrUUN3ME20MlM{PzhizszN NVmwWJFFW0GQR1XS
SK-OV-3 NWXaS5NpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jkXWlEPTB;ND60PFE1QSEQvF2= MlT3V2FPT0WU
LOUCY M1;QSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4e4PGlEPTB;ND60PFQ{OiEQvF2= Ml\iV2FPT0WU
NCI-H69 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mny3TWM2OD12LkWxO|k{KM7:TR?= M4O2WnNCVkeHUh?=
SCC-9 NGPSfpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHy1N|JKSzVyPUSuOVMyPzJizszN MoHlV2FPT0WU
NCI-H526 NEjuOGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;RO2lEPTB;ND61PVI6OyEQvF2= NGryXWRUSU6JRWK=
NCI-H2170 Mo[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzETWM2OD12Lk[2O|cyKM7:TR?= MmTKV2FPT0WU
SR MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHSWZFnUUN3ME20MlcxODR6IN88US=> M2fzW3NCVkeHUh?=
CMK MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnRO3o1UUN3ME20MlczOTBzIN88US=> NXL4fYtVW0GQR1XS
COLO-829 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXybG53UUN3ME20Mlc4ODR|IN88US=> NVvJR5UyW0GQR1XS
HuO-3N1 MlnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfBTWM2OD12LkizNlgyKM7:TR?= MnS4V2FPT0WU
5637 M2H2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTRwOUC0PFch|ryP NVrKOm5IW0GQR1XS
A253 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{D4NWlEPTB;ND65O|cxQCEQvF2= MkXmV2FPT0WU
NB10 NHW0Ro1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjRZlFKSzVyPUWuNFc1QTdizszN MYPTRW5ITVJ?
SF539 M1nuVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvXWWpKSzVyPUWuNFk6PTlizszN NVTwfItQW0GQR1XS
HAL-01 M2jGVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4H1bmlEPTB;NT6xOFY1PSEQvF2= NWL3UYhDW0GQR1XS
MHH-ES-1 M2X0d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nYS2lEPTB;NT6xOlkzPSEQvF2= NYfRfnFSW0GQR1XS
DEL M2H1fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUixbW5DUUN3ME21MlI4PTh{IN88US=> MVjTRW5ITVJ?
NCI-H1299 Mn;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGixR2pKSzVyPUWuN|UxODdizszN Mn7MV2FPT0WU
ChaGo-K-1 NYLLd4dUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DKfGlEPTB;NT6zOVExPyEQvF2= NXnmRWprW0GQR1XS
HMV-II NVP5[YR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7tTWM2OD13LkO5OFMh|ryP NYH1[m4xW0GQR1XS
NB69 M1nOVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYK2NYxRUUN3ME21MlM6PjNzIN88US=> NXPFepc4W0GQR1XS
NCI-H1882 MljGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHITWM2OD13LkSzN|Y1KM7:TR?= MVzTRW5ITVJ?
SNU-475 M1q0[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHO5bpZKSzVyPUWuOFcyPzFizszN M3XwUXNCVkeHUh?=
RXF393 NWn3fmZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrWPIVNUUN3ME21MlQ5PDl2IN88US=> NF;sXZRUSU6JRWK=
CAL-51 M3nTSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXqycYZtUUN3ME21MlYzQDV|IN88US=> MY\TRW5ITVJ?
SW1573 NVLJSpJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfFTWM2OD13Lk[zOVM1KM7:TR?= NXKwUY5iW0GQR1XS
GCT MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\oTWM2OD13Lke1PVI6KM7:TR?= MlTWV2FPT0WU
COR-L88 NVvQdFhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXHcndKSzVyPUWuO|Y5PDZizszN M2jJV3NCVkeHUh?=
MDA-MB-134-VI MmrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TPXmlEPTB;NT64O|U{PiEQvF2= NXrhcmR5W0GQR1XS
NB5 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnsS3JoUUN3ME21MlkzPDRizszN MVnTRW5ITVJ?
GMS-10 MkjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXQNXBKSzVyPUWuPVY5PjFizszN MkfLV2FPT0WU
CHP-212 MmjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYO1SHZKUUN3ME22MlQ5OjZ5IN88US=> MYfTRW5ITVJ?
TE-11 MoT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTZwNUWxPFIh|ryP Mlu3V2FPT0WU
SW962 NI\3NG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHKPHZ2UUN3ME22MlY2Pzd2IN88US=> M4X2e3NCVkeHUh?=
MZ2-MEL NFTTTXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGH0VI9KSzVyPU[uPFIxOTFizszN NELwUFlUSU6JRWK=
C-33-A NFfWVnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjXTWM2OD14LkmxOlg5KM7:TR?= M33UfnNCVkeHUh?=
IGR-1 NFrrfJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTZwOUe4NlYh|ryP Ml[2V2FPT0WU
MOLT-4 NILRO21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;kTWM2OD15LkG1OFA3KM7:TR?= NHzGc3BUSU6JRWK=
NCI-H1650 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXqTWM2OD15LkK3NFQ3KM7:TR?= MlvvV2FPT0WU
AsPC-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTdwMki2NFUh|ryP NFfjV5ZUSU6JRWK=
SNU-C2B Mm\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTdwMkm1O|Eh|ryP Mm\YV2FPT0WU
MKN7 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTdwM{eyN|Uh|ryP M1;aSnNCVkeHUh?=
SW620 Ml;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXpZWVKSzVyPUeuN|gzODVizszN NIfGWZdUSU6JRWK=
SK-MEL-28 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;DTWM2OD15LkSwO|k5KM7:TR?= NX\wd3FrW0GQR1XS
TE-6 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHqx[3VKSzVyPUeuOFQ6ODhizszN Moq5V2FPT0WU
D-263MG MmLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LhTWlEPTB;Nz60OVc3OiEQvF2= MnvGV2FPT0WU
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OAW-28 MlrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUX6THBQUUN3ME2xNE46QDh6IN88US=> NYTSUI1bW0GQR1XS
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CAL-33 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3aboRKUUN3ME2xPE4zPzhzIN88US=> MVvTRW5ITVJ?
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CAL-62 NH7lN25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3T4U2lEPTB;MkKuO|UyPyEQvF2= NXuy[4w4W0GQR1XS
HCE-T MnHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zFXmlEPTB;MkKuPFYxPiEQvF2= MmD2V2FPT0WU
BB65-RCC NWnufWZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnLNGM3UUN3ME2yN{4xOzR2IN88US=> NUfCTXFkW0GQR1XS
SiHa NHjuTW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkS4TWM2OD1{Mz6zPVY5KM7:TR?= MXPTRW5ITVJ?
NCI-H2081 NWX0d|lVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XXTGlEPTB;MkSuNFY1OSEQvF2= NIjDS49USU6JRWK=
U251 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTJ2LkC2Olgh|ryP MkDqV2FPT0WU
LoVo NFTPWW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjQTWM2OD1{ND65NlgzKM7:TR?= MY\TRW5ITVJ?
GCIY NXvmS5FJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTJ3LkK4O|ch|ryP NIrkdGFUSU6JRWK=
NUGC-3 NI[2bpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnq2TWM2OD1{NT6zN|E3KM7:TR?= NGjCS5FUSU6JRWK=
LNCaP-Clone-FGC NV;4dm94T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXlRYdKSzVyPUK1MlM1QThizszN M1vzZXNCVkeHUh?=
PA-1 M{PMV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTJ3Lk[4N|Mh|ryP NIjqNGFUSU6JRWK=
OE33 MmfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVT4PFlmUUN3ME2yOU43QDV|IN88US=> NYf3fXNxW0GQR1XS
HT-29 NVHmfphsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;4TVJKSzVyPUK1Mlc5PzlizszN MX;TRW5ITVJ?
RCM-1 NH;4fFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorpTWM2OD1{NT65OlU3KM7:TR?= NIH1UnNUSU6JRWK=
NCI-H1522 M3;5Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTJ3Lkm5NVEh|ryP MYDTRW5ITVJ?
LB373-MEL-D M3q2e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljVTWM2OD1{Nj6xO|A5KM7:TR?= M{jVXXNCVkeHUh?=
NCI-H1436 NYXPV3hQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXh[WJzUUN3ME2yOk4zPzN6IN88US=> NYj1V3RvW0GQR1XS
COLO-824 MnO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7wfYRKSzVyPUK2MlQxODJizszN M1;OVnNCVkeHUh?=
CP50-MEL-B M2PDNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzXXlhKSzVyPUK2MlU3PzVizszN NYTtUIdoW0GQR1XS
EGI-1 NWH1S3VQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3GSmFKSzVyPUK3MlI3QThizszN M1OzSnNCVkeHUh?=
LAN-6 NHewOI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvwc2tKSzVyPUK3MlM2QThizszN M2\5WXNCVkeHUh?=
GAK MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTJ5LkSyNlUh|ryP MXrTRW5ITVJ?
MDA-MB-175-VII Mnu5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH:2VItKSzVyPUK3MlUxPTNizszN MkPsV2FPT0WU
JVM-2 MoryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rPdmlEPTB;MkeuOlYzOiEQvF2= M1XHNXNCVkeHUh?=
UACC-257 NYjoU5NLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TSbWlEPTB;MkeuOlg4QCEQvF2= NGXuR4NUSU6JRWK=
SW1783 NWTremt2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDjTWM2OD1{Nz63O|g{KM7:TR?= NFf4S3FUSU6JRWK=
HT-3 M3XUVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTJ6LkKxOlYh|ryP M{S2fXNCVkeHUh?=
RL MlXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4O3S2lEPTB;MkiuOVkyOSEQvF2= NEnKW29USU6JRWK=
TK10 NWfaS|ZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLNTWM2OD1{OD62OVM2KM7:TR?= M{nEcnNCVkeHUh?=
HT55 NWLS[ppbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYm4cYpmUUN3ME2yPU4xPTZ3IN88US=> MmXnV2FPT0WU
BT-20 MlfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHGTWM2OD1{OT6wOVg3KM7:TR?= M{DGW3NCVkeHUh?=
TGBC24TKB NFnXOYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnZTWM2OD1{OT6xPFMyKM7:TR?= MoDuV2FPT0WU
HSC-2 M2[4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWn4NXVIUUN3ME2yPU4{ODBzIN88US=> NXn6TFRMW0GQR1XS
COLO-205 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nndGlEPTB;MkmuN|k1PCEQvF2= NFvN[I5USU6JRWK=
GT3TKB MkXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXFOIVPUUN3ME2yPU43QDd5IN88US=> NHLp[JdUSU6JRWK=
T47D M3HINGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoKzTWM2OD1{OT64OVgzKM7:TR?= NGjTPXJUSU6JRWK=
OMC-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoD2TWM2OD1|MD6xPVE6KM7:TR?= MUfTRW5ITVJ?
PFSK-1 NVnoSWhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTNzLkK2OVkh|ryP M4Wxe3NCVkeHUh?=
JEG-3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHJTWM2OD1|MT6zOVYyKM7:TR?= NWfteWVrW0GQR1XS
RD MmL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTNzLkWxNVUh|ryP NIfFcHNUSU6JRWK=
NCI-H64 NEfGRZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTN{LkSxO|kh|ryP NH;mUI5USU6JRWK=
DMS-114 NEXhW|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDscoF5UUN3ME2zNk41OTh{IN88US=> M4XyTXNCVkeHUh?=
NCI-H661 Mo[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3qzZ2lEPTB;M{KuOlUxOSEQvF2= NELuc3dUSU6JRWK=
CAL-148 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPYT3RKSzVyPUOyMlY3PjVizszN M4f5VHNCVkeHUh?=
HuP-T3 M3LEPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPTcJNKSzVyPUOyMlk{OzhizszN M2\Y[XNCVkeHUh?=
ES4 NYjQT5hTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfZTWM2OD1|Mz6xO|A2KM7:TR?= NVf5eGR2W0GQR1XS
Ca9-22 NI\1[WVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTN|LkS2NFEh|ryP MX;TRW5ITVJ?
LP-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLsTWM2OD1|ND6wPUDPxE1? MXvTRW5ITVJ?
AU565 M{jHbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTN2LkWwOlkh|ryP MWHTRW5ITVJ?
MDA-MB-453 M1\KOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfwR5BKSzVyPUO1MlE1OjZizszN MUjTRW5ITVJ?
SNU-C1 Mn:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTN3LkG3NUDPxE1? M3ToO3NCVkeHUh?=
SW13 NYPDTINrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTN3LkSwO|Yh|ryP MV;TRW5ITVJ?
NCI-H2122 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnvSZFKSzVyPUO1MlU2QThizszN NUm4UYxyW0GQR1XS
NCI-H1395 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFr3U2xKSzVyPUO1MlY3QTFizszN Mlm4V2FPT0WU
J-RT3-T3-5 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrqUG5OUUN3ME2zOk4xOjl2IN88US=> NFnIe41USU6JRWK=
COR-L279 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTscpBsUUN3ME2zOk4yQThzIN88US=> NVrxSZc2W0GQR1XS
ATN-1 M3HPfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETOSGhKSzVyPUO2Mlg2OTZizszN M1XKcXNCVkeHUh?=
HCC2998 NWXmeG9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHlTWM2OD1|Nj64OVcyKM7:TR?= NGLXXYJUSU6JRWK=
UM-UC-3 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\vTWM2OD1|Nj64Olc2KM7:TR?= MkfCV2FPT0WU
DV-90 NEf5U|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mon4TWM2OD1|Nj65NFY4KM7:TR?= NXfxcW1iW0GQR1XS
ES8 NEHiclVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWH2eolPUUN3ME2zOk46OzF6IN88US=> NVvJVW9LW0GQR1XS
YAPC M4jZd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fjXWlEPTB;M{[uPVY2PCEQvF2= MV7TRW5ITVJ?
HCC1599 NVfiRolqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXGTWM2OD1|Nz6xOlE5KM7:TR?= NWfRPI1IW0GQR1XS
UMC-11 NE\JNYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTN5LkK1NFMh|ryP NXnDW2ZFW0GQR1XS
THP-1 Mn;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPiTWM2OD1|Nz6yPFY5KM7:TR?= NFXrbJVUSU6JRWK=
OCUB-M NHG5N3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTOdWhRUUN3ME2zO{4zQDlzIN88US=> MmX5V2FPT0WU
NCI-H1693 MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlq0TWM2OD1|Nz6zNlM{KM7:TR?= NHTp[W1USU6JRWK=
NCI-H345 MkXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DZUGlEPTB;M{euN|YzPCEQvF2= NITKU|hUSU6JRWK=
COLO-800 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTN5LkW2O{DPxE1? M{ixWHNCVkeHUh?=
COLO-320-HSR MoG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\2e4NHUUN3ME2zPE4{PDl{IN88US=> Mn3nV2FPT0WU
NCI-H596 MojJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTN6LkS0PFkh|ryP MXfTRW5ITVJ?
NCI-H187 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHoTWM2OD1|OD63N|Q1KM7:TR?= M1XmdXNCVkeHUh?=
ECC4 M3rpbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXtNJF1UUN3ME2zPU4xQDF2IN88US=> NVexd5dCW0GQR1XS
KP-4 NIr2XWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjNNnZKSzVyPUO5MlEzOzVizszN MkLyV2FPT0WU
NCI-H2227 NF7ISHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTN7LkO5OFkh|ryP NWqySXpoW0GQR1XS
22RV1 MnPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3yS5JiUUN3ME2zPU45Ozl6IN88US=> MnrtV2FPT0WU
SAS Mo\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTRyLkC5OkDPxE1? Mnr3V2FPT0WU
PANC-10-05 M{j0UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTRyLkG4Nlgh|ryP MXTTRW5ITVJ?
MDA-MB-468 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPkTWM2OD12MD61N|Q3KM7:TR?= NYjWZ|JFW0GQR1XS
RPMI-7951 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfkc3pKSzVyPUSxMlIxPzVizszN M1vyO3NCVkeHUh?=
BB49-HNC MmXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\pNZVXUUN3ME20NU4zOTd7IN88US=> M1LFVHNCVkeHUh?=
23132-87 MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPGWYlKSzVyPUSxMlI4OzJizszN NIjiRVVUSU6JRWK=
HCC1569 NHXPenNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGf2botKSzVyPUSxMlI5QDVizszN M3foUHNCVkeHUh?=
CP66-MEL NInJSWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;BXo1XUUN3ME20Nk4yQDh4IN88US=> NWLEXlR[W0GQR1XS
K-562 NF2zZ5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnWwTWM2OD12Mj6yPFU1KM7:TR?= MnuzV2FPT0WU
OCI-AML2 M4LROGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4r0OWlEPTB;NEKuPFk4PCEQvF2= NFnYUYNUSU6JRWK=
SW756 NFXyRYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTR|LkCzPFgh|ryP NXPjTZMyW0GQR1XS
M14 M{O5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nZSWlEPTB;NEOuN|E5QSEQvF2= M1TXW3NCVkeHUh?=
NCI-H1623 Ml\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\KTWM2OD12Mz60OlQh|ryP NFH3bVdUSU6JRWK=
KNS-81-FD MnPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrQeno4UUN3ME20N{44PjJizszN MlS4V2FPT0WU
TGBC1TKB NY\P[lRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jI[2lEPTB;NEOuPVA6QSEQvF2= MnHpV2FPT0WU
RERF-LC-MS Mof0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnoTWM2OD12Mz65NlgyKM7:TR?= MWTTRW5ITVJ?
PC-3 NI\ScW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:wTJdtUUN3ME20OE41OzR5IN88US=> NVe3eoxMW0GQR1XS
HuP-T4 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PjPGlEPTB;NESuOFQ4PCEQvF2= NWLkd5RsW0GQR1XS
NCI-H510A MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7iemU3UUN3ME20OE44ODhizszN M3LyW3NCVkeHUh?=
LB2518-MEL M4\UNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjUflFKSzVyPUS0Mlc6OzdizszN MlfUV2FPT0WU
TE-5 NITGXphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTR3Lkm1PFEh|ryP Ml7DV2FPT0WU
EW-24 NHS5UmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTR4LkG3NlMh|ryP MUHTRW5ITVJ?
LB647-SCLC MlXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTR4LkKxOVUh|ryP MXHTRW5ITVJ?
NCI-H524 M2\JO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zhZmlEPTB;NE[uO|E5PSEQvF2= NHL3SoxUSU6JRWK=
EW-11 MnzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPibXBKSzVyPUS2Mlk{PzNizszN M4XTfXNCVkeHUh?=
KALS-1 NVf1VoZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHUPVFJUUN3ME20O{4zODZ4IN88US=> MWDTRW5ITVJ?
BT-474 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjTbolrUUN3ME20O{41OjF4IN88US=> NVfHe45ZW0GQR1XS
SK-N-AS M1z5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLtTZJOUUN3ME20O{45QDhizszN NFnQOY9USU6JRWK=
HCC2157 NUjwVGpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnOwTWM2OD12OD6wO|Yh|ryP MXTTRW5ITVJ?
HCC1954 MorYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzLUnFwUUN3ME20PE4yPzB2IN88US=> MoT4V2FPT0WU
FADU NYn4W|ZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\0TWM2OD12OD6zNFMyKM7:TR?= MYXTRW5ITVJ?
S-117 NX2ySmprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlewTWM2OD12OD6zPFE2KM7:TR?= MnLuV2FPT0WU
LS-1034 MkKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTR6LkewOlch|ryP MoX4V2FPT0WU
CAMA-1 NEeyb3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDz[XBZUUN3ME20PU42PTR|IN88US=> NIH5T3dUSU6JRWK=
LU-134-A M3TXTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvtTWM2OD12OT64NFg2KM7:TR?= MkWxV2FPT0WU
NCI-H1838 MkHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rMNmlEPTB;NEmuPFA5PyEQvF2= M3[xd3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pSrc / Src / pPlcg / Plcg / pStat5 / Stat5 ; 

PubMed: 22781593     


In (B) inhibition of Src, Plcg and Stat5 was seen in MLNAF cell lines treated with Ponatinib; ZNF112 expresses ZMYM2–FGFR1, CEP2A and CEP5A cells express CEP110–FGFR1 and BBC2 expresses BCR–FGFR1.

pFGFR1(pY20) / FGFR1; 

PubMed: 22781593     


Western blot analysis, using various antibodies specific for downstream targets of FGFR1, demonstrates that Ponatinib inhibits the activation of Plcg and Src as a result of inhibiting the FGFR1 fusion kinase in human KG1 cells. 

cleaved caspase-3 / cleaved caspase-7 / BAX / Bcl-2; 

PubMed: 30959969     


Western blot analysis of cleaved caspase-3, cleaved caspase-7, Bax, Bcl-2, and β-Tubulin (control) in treated cells.

p-Rb(S807/811) / Rb / CDK4 / CDK6 / Cyclin D1 / CDK2 / Cyclin E1; 

PubMed: 30959969     


Western blot analysis of Rb/p-Rb, CDK4, CDK6, Cyclin D1, CDK2, Cyclin E1, and β-Tubulin (control) in the SK-Hep-1 and SNU-423 cells treated with ponatinib. 

RAD51; 

PubMed: 30959969     


The effect of ponatinib on the concentration of Rad51 in SK-Hep-1 and SNU-423 cells.

p-MEK / MEK / p-ERK / ERK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Mek and Erk. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

c-Jun / p-JNK(T183/Y185) / JNK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of JNK and c-Jun. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-p38 MAPK / p38 MAPK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of p38. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-JAK2 / JAK2 / p-STAT3 / STAT3; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Jak2, and Stat3. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

PI3K p85 / p-PI3K / p-PDK1 / PDK1 / p-mTOR / mTOR; 

PubMed: 30959969     


Effects of ponatinib on the protein concentration and phosphorylation of PI 3-kinase, PDK1, Akt, and mTOR in HCC cells. 

p-PDGFRα / PDGFRα; 

PubMed: 24472312     


Ponatinib inhibited phosphorylation of PDGFRα in a concentration-dependent manner. EOL-1 and BaF3-WT or -T674I FIP1L1-PDGFRα cells were exposed to escalating concentrations of ponatinib for 24 h.

PARP / Caspase-3 / Active Caspase-3; 

PubMed: 24472312     


The concentration- (for 24 h) and time-dependent (1 nM for EOL-1, 300 nM for BaF3-WT and -T674I FIP1L1-PDGFRα cells) cleavage of PARP and caspase-3 triggered by ponatinib was analyzed by immunoblotting.

AIF / Cyto C ; 

PubMed: 24472312     


Ponatinib elicited release of AIF and cytochrome c into the cytosol. Cells were treated with 1 nM ponatinib for the indicated durations and the cytosolic fraction was extracted with digitonin buffer. Levels of AIF and Cytochrome c (Cyto c) were detected by immunoblotting.

Mcl-1 / Survivin / Bcl-Xl / XIAP / Bax / Bcl-2 / Bim; 

PubMed: 24472312     


Immunoblotting of apoptosis-related proteins in CEL cells after treatment for 24 h.

β-catenin ; 

PubMed: 24472312     


Ponatinib concentration-dependently lowered β-catenin. EOL-1 cells were incubated with ponatinib for 24 h, and cytoplasmic and nuclear extracts were determined by immunoblotting.

β-catenin; 

PubMed: 24472312     


Analysis of β-catenin localization. EOL-1 cells were pretreated with 1 nM ponatinib for 24 h, immunofluorescence analysis was performed with anti-β-catenin. Nuclei were stained with 4,6-diamidino-2-phenylindole (DAPI). 

ABL; 

PubMed: 19878872     


In vitro [γ-32P]-ATP autophosphorylation of full-length (A) ABL or (B) ABLT315I kinase treated with AP24534, imatinib, nilotinib, or dasatinib. After incubation of tyrosine-dephosphorylated enzyme with the indicated inhibitor in the presence of [γ-32P]-ATP and separation by SDS-PAGE, signal intensity was measured by autoradiography.

22781593 30959969 24472312 19878872
Growth inhibition assay
Cell viability; 

PubMed: 30174789     


(A) Effect of Ponatinib on basal viability of HUVECs. The cells were treated with Ponatinib at indicated concentrations or 0.1% DMSO (vehicle control) for 24 h.

30174789
体内研究 Ponatinib抑制取自FLT3-ITD阳性AML病人的原代白血病细胞,而不抑制表达阴性FLT3的AML病人的白血病细胞。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
- 合并

激酶实验:

通过同质时间分辨荧光共振能量转移法(TR-FRET),使用纯化的人类野生型ABL激酶,T315I突变型ABL激酶,及生物素化的磷酸激酶底物肽: 生物素-EKKMAAEAIYAAPFAK-NH2,测定野生型ABL和T315I突变型ABL活性的抑制激酶反应在全LANCE激酶buffer (LKB)中进行,LKB包括20 mM NaHEPES(pH 为7.4), 0.1 mg ⁄ mL BSA, 1 mM ATP, 10 mM MgCl2, 及0.41 mM DTT,在提前用1% BSA(溶于PBS)包被的96孔板上4oC下过夜。用于激酶反应,Ponatinib稀释物和野生型ABL, T315I突变型ABL (40 pM), 及底物肽(50 nM), 在室温下温育1小时(T315I突变型ABL)或2小时(野生型ABL)。加入15 nM 抑制剂, 6 nM 铕标记的磷酸酪氨酸抗体(磷酸化位点在第66为酪氨酸上),及60 nM 别藻蓝素标记的链酶亲和素,终止反应。实验板在室温下黑暗温育20分钟,使用Wallac Victor2V读数器读取615和665nm处的荧光值。在孔中数据平均值中插入抑制剂的3倍连续稀释液,再读取665nm处荧光值,计算IC50值。
细胞实验:[1]
- 合并
  • Cell lines: Ba ⁄ F3细胞
  • Concentrations: 0-625 nM, 和0-10 µM
  • Incubation Time: 72小时
  • Method: Ba/F3细胞系按每孔4×103个细胞分布在96孔板上(4×103),和梯度浓度Ponatinib温育72小时。Ponatinib浓度范围为: 0-625 nM 作用于表达BCR-ABL细胞,0-10 µM 用于测定BCR-ABL阴性细胞。使用MTS实验测定细胞增殖,取三次平行实验平均值测定IC50值。
    (Only for Reference)
动物实验:[3]
- 合并
  • Animal Models: 皮下植入MV4-11细胞移植瘤(1×107,50%基质胶中) 的雌性CB.17 SCID鼠
  • Dosages: 每天处理一次,持续4周
  • Administration: 口服饲喂处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
1% CMC Na
30mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 532.56
化学式

C29H27F3N6O

CAS号 943319-70-8
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04160546 Recruiting Drug: Ponatinib 15 MG|Drug: Acetylsalicylic acid 100 MG Chronic Myeloid Leukemia Chronic Phase Fundacion CRIS de Investigación para Vencer el Cáncer|Incyte Biosciences UK|Apices Soluciones S.L. January 17 2020 Phase 2
NCT04070443 Recruiting Drug: Ponatinib|Drug: Imatinib Philadelphia Chromosome Positive CML|BCR-ABL Positive Chronic Myelogenous Leukemia Centre Leon Berard November 13 2019 Phase 2
NCT03934372 Recruiting Drug: Ponatinib Acute Myeloid Leukemia|Accelerated Phase Chronic Myeloid Leukemia|Blast Phase Chronic Myeloid Leukemia|Chronic Phase Chronic Myeloid Leukemia|Acute Lymphoblastic Leukemia|Acute Lymphocytic Leukemia|Leukemia|Lymphoma|Solid Tumors Incyte Biosciences International Sàrl|Incyte Corporation November 22 2019 Phase 1|Phase 2
NCT03895671 Recruiting Drug: Ponatinib|Drug: Azacitidine CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE|CHRONIC MYELOGENOUS LEUKAEMIA IN MYELOID BLAST CRISIS Versailles Hospital June 19 2019 Phase 2
NCT03690115 Recruiting Drug: Ponatinib 30 MG Leukemia Myeloid Acute Versailles Hospital December 12 2018 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID