Ponatinib (AP24534)

For research use only. Not for use in humans.

目录号:S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534)是一种新型有效的多靶点抑制剂,在无细胞试验中作用于Abl,PDGFRα,VEGFR2,FGFR1和Src,IC50分别为0.37 nM,1.1 nM,1.5 nM,2.2 nM和5.4 nM。Ponatinib (AP24534)可抑制自噬。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 819.31 现货
RMB 903.01 现货
RMB 3034.48 现货
RMB 7959.08 现货
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客户使用Selleck生产的Ponatinib (AP24534)发表文献95篇:

产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

产品描述 Ponatinib (AP24534)是一种新型有效的多靶点抑制剂,在无细胞试验中作用于Abl,PDGFRα,VEGFR2,FGFR1和Src,IC50分别为0.37 nM,1.1 nM,1.5 nM,2.2 nM和5.4 nM。Ponatinib (AP24534)可抑制自噬。
靶点
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外研究

Ponatinib是有效的可用于口服的多靶点激酶抑制剂,作用于野生型细胞,及T315I 突变细胞IC50分别为1.2和8.8nM。[1] Ponatinib抑制Ba/F3衍生细胞系的增殖。[2] Ponatinib作用于表达野生型或T315I突变型BCR-ABL的CML细胞系,有效抑制BCR-ABL调节的信号。Ponatinib阻断在细胞瘤筛选时产生抗性突变。[3] Ponatinib也抑制VEGFR和FGFR家族激酶,在体外抑制FLT3, KIT, FGFR1,和PDGFRa激酶活性时IC50分别为13, 13, 2, 和1 nM.[4]Ponatinib抑制全部4种RTKs磷酸化,存在剂量依赖性,IC50值为0.3到20 nM。然而,Ponatinib抑制表达野生型FLT3的RS4;11细胞时IC50>100 nM。

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell MkXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml6wTWM2OD1yLkCwNFAxODB|NUmg{txO Mn:xV2FPT0WU
MV-4-11 NWPVfWVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPCNoxJUUN3ME2wMlAxODB7NU[g{txO NYDR[nk6W0GQR1XS
MEG-01 Mk\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTJXGFOUUN3ME2wMlAxODF{ODFOwG0> M3exeXNCVkeHUh?=
LAMA-84 NIC2VG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPzTWM2OD1yLkCwNFE3PSEQvF2= MYDTRW5ITVJ?
CGTH-W-1 NU\wPZpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3jO21jUUN3ME2wMlAxOTZ7IN88US=> NUfQeGhqW0GQR1XS
KASUMI-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjoTWM2OD1yLkCwNlE4KM7:TR?= NH7UfHVUSU6JRWK=
BE-13 Mn6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1riW2lEPTB;MD6wNFI2QSEQvF2= NFe1eXVUSU6JRWK=
CTV-1 NWfRcJBoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPRVI5zUUN3ME2wMlAxPTJzIN88US=> Mn21V2FPT0WU
NKM-1 NYTxNpF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV30PY9DUUN3ME2wMlAxPjV3IN88US=> MWDTRW5ITVJ?
MONO-MAC-6 MkXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TMd2lEPTB;MD6wNFg{PyEQvF2= MUPTRW5ITVJ?
A204 MkTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zOcGlEPTB;MD6wNVIyQCEQvF2= MULTRW5ITVJ?
GDM-1 NUDZSWVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\BdZdPUUN3ME2wMlAyQDN|IN88US=> NGnkdVdUSU6JRWK=
AN3-CA NFvnW4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVG1e3UyUUN3ME2wMlAyQDd|IN88US=> MXTTRW5ITVJ?
BL-70 NHrWZ25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXuTWM2OD1yLkCyNVk6KM7:TR?= NH;F[HZUSU6JRWK=
Daudi NGfDbINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HLcGlEPTB;MD6wNlU{PyEQvF2= NFvwSYFUSU6JRWK=
KU812 MoHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnuTWM2OD1yLkCyPFQ5KM7:TR?= MUHTRW5ITVJ?
KG-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjYZ4dGUUN3ME2wMlA{Ojl2IN88US=> M3HXUXNCVkeHUh?=
DOHH-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1L3PWlEPTB;MD6wOFgxOyEQvF2= MlzJV2FPT0WU
HuO9 M135dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn34TWM2OD1yLkC1OFQ5KM7:TR?= M4TodXNCVkeHUh?=
EB2 Mon3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\pTWM2OD1yLkC1OVc3KM7:TR?= MmfwV2FPT0WU
G-402 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4H0NGlEPTB;MD6wOlM1OSEQvF2= M1XWZnNCVkeHUh?=
SU-DHL-1 NUnxUW1wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwME[zO|kh|ryP NH[yRZBUSU6JRWK=
NCI-H719 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMEe4PFgh|ryP MVvTRW5ITVJ?
MLMA M4qw[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\F[FJKSzVyPUCuNFkxPiEQvF2= NWnmRZFVW0GQR1XS
KM12 Mk\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\SSYlKSzVyPUCuNFk4OzdizszN MULTRW5ITVJ?
SUP-T1 NHPIWJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DudGlEPTB;MD6wPVk5OiEQvF2= MYPTRW5ITVJ?
MZ1-PC MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMUGzN|Yh|ryP M13k[XNCVkeHUh?=
MFE-296 M4\QfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4OwSWlEPTB;MD6xNVg{QSEQvF2= Mke5V2FPT0WU
ALL-PO MmjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7XTWM2OD1yLkGyOFQ{KM7:TR?= MWDTRW5ITVJ?
GB-1 M2rmOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2exTGlEPTB;MD6xNlUyOiEQvF2= MUDTRW5ITVJ?
SIG-M5 MlTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMUOzO{DPxE1? M3nvdHNCVkeHUh?=
P30-OHK M3zKVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7YR4RmUUN3ME2wMlE2Pjd{IN88US=> NHLIbIhUSU6JRWK=
NCI-H716 M4LDT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\wZ|ZUUUN3ME2wMlE3OjZ4IN88US=> M4j5V3NCVkeHUh?=
MPP-89 NF3KS3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkX2TWM2OD1yLkG2PVM{KM7:TR?= MkXMV2FPT0WU
SF126 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1y0eGlEPTB;MD6xO|A3OyEQvF2= Mlv5V2FPT0WU
CTB-1 NWLDVJpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMUezNVYh|ryP M4rEXHNCVkeHUh?=
CA46 NYHvVotJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\GTWM2OD1yLkG3OFg6KM7:TR?= M2f0d3NCVkeHUh?=
NCI-H520 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHz5d3FKSzVyPUCuNVc4OzJizszN NXXJS3hPW0GQR1XS
CAL-85-1 M1u0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlmwTWM2OD1yLkG3PVI4KM7:TR?= M{TmVXNCVkeHUh?=
NCI-H2342 M3P4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LDRWlEPTB;MD6xPFU4PyEQvF2= NGGybZFUSU6JRWK=
697 NXfOTnVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLRTWM2OD1yLkG4PFcyKM7:TR?= NHTmcFNUSU6JRWK=
NY MoHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHRdHloUUN3ME2wMlE6Ojh5IN88US=> M2L4UXNCVkeHUh?=
T98G NIfoN3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2KzdGlEPTB;MD6xPVMyQCEQvF2= NHX3V4tUSU6JRWK=
NCI-H1703 NHvsV3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFP6[4pKSzVyPUCuNVk3OTVizszN NVjZVYQ5W0GQR1XS
NCI-H2087 NEnodXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\hTWM2OD1yLkKwOFM6KM7:TR?= MXvTRW5ITVJ?
PF-382 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[4NJhRUUN3ME2wMlIxQDd|IN88US=> MkXCV2FPT0WU
HCT-116 MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\tU2lEPTB;MD6yNVA3QSEQvF2= NWjCfJdlW0GQR1XS
CAKI-1 MkDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFK2[m5KSzVyPUCuNlE3PjZizszN MkfyV2FPT0WU
CCF-STTG1 MnK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\sNmQzUUN3ME2wMlIzPDd3IN88US=> NGfmZ2xUSU6JRWK=
D-392MG MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3WTIZWUUN3ME2wMlI{OTd5IN88US=> MW\TRW5ITVJ?
RT-112 M4TBUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXkTWM2OD1yLkKzO|k2KM7:TR?= NVTHWm04W0GQR1XS
MES-SA M3G5Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMkSxPFch|ryP M1zsTnNCVkeHUh?=
LC-2-ad MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7YW2lKSzVyPUCuNlQzPjVizszN MYrTRW5ITVJ?
NOS-1 MlH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzCTWM2OD1yLkK0N|Y4KM7:TR?= MnXDV2FPT0WU
NALM-6 MkPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEC4UJJKSzVyPUCuNlU2PDNizszN MVHTRW5ITVJ?
TE-15 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\aTWM2OD1yLkK2NFkyKM7:TR?= M1zrOXNCVkeHUh?=
786-0 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFX6UYVKSzVyPUCuNlYzOjhizszN MYDTRW5ITVJ?
IST-MES1 NF;2OItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLSUYFKSzVyPUCuNlY5OjlizszN NH\1fZFUSU6JRWK=
KYSE-180 M{PWWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknxTWM2OD1yLkK2PFkyKM7:TR?= NWXkZpZVW0GQR1XS
YT MnHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXRTWM2OD1yLkK2PVc1KM7:TR?= M{D1RnNCVkeHUh?=
A427 NES1c5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3r3e2lEPTB;MD6yO|I3PCEQvF2= MUXTRW5ITVJ?
KYSE-450 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zYXWlEPTB;MD6yO|MzQSEQvF2= MkjuV2FPT0WU
HuH-7 M4LRUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\MeHRXUUN3ME2wMlI4PzZ|IN88US=> NIrQcZhUSU6JRWK=
CAS-1 Mk\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrIOXVKSzVyPUCuNlg{ODNizszN NF36TlJUSU6JRWK=
KURAMOCHI MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfSdoVKSzVyPUCuNlg1OTlizszN M2LMW3NCVkeHUh?=
ACHN M3vBVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;TOpNKSzVyPUCuNlk{OjNizszN NEfXXGFUSU6JRWK=
HGC-27 Mn\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXr3VZFMUUN3ME2wMlI6OzV|IN88US=> NWHR[HE2W0GQR1XS
A172 M1SzWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmO5TWM2OD1yLkK5OVc4KM7:TR?= MX;TRW5ITVJ?
SNU-449 MmHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMkm5OlQh|ryP NXv6Rms{W0GQR1XS
SW982 MofpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlr1TWM2OD1yLkK5PVc5KM7:TR?= NUTUfZkyW0GQR1XS
EFO-21 M{fKNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEm5V5FKSzVyPUCuN|A1OTFizszN MofVV2FPT0WU
NCI-H2030 NFPTfnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwM{GxOlQh|ryP MkDHV2FPT0WU
HT-144 NYDMTFJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HoXGlEPTB;MD6zNVI5KM7:TR?= Mn7nV2FPT0WU
MFE-280 MoHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwM{G0OVMh|ryP NVfxUJZ1W0GQR1XS
SK-LU-1 NFzKWlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwM{G0OlYh|ryP NGCyfm1USU6JRWK=
NCI-H2052 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETHcVBKSzVyPUCuN|E1QDRizszN M323TXNCVkeHUh?=
SK-HEP-1 MnXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\FTWM2OD1yLkOzN|Y5KM7:TR?= MXPTRW5ITVJ?
QIMR-WIL NXfQZm4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwM{O0NlQh|ryP NGPxfFdUSU6JRWK=
A2780 M1SxWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rremlEPTB;MD6zOFMxPCEQvF2= NYH4eY5OW0GQR1XS
ACN NYSwfVduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwM{S4O|Mh|ryP NX[1bllmW0GQR1XS
BxPC-3 Mn21S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHe1enZKSzVyPUCuN|Q6QDlizszN MV3TRW5ITVJ?
BCPAP MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnyZpRpUUN3ME2wMlM3ODBzIN88US=> MmXsV2FPT0WU
HOP-62 M3SxZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;lTWM2OD1yLkO2NVA3KM7:TR?= NIrSenhUSU6JRWK=
SW1710 NFjnTY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13hN2lEPTB;MD6zOlQ2PSEQvF2= MX7TRW5ITVJ?
OPM-2 NUG3OW1FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrCO5ZKSzVyPUCuN|Y1PzNizszN Mn\LV2FPT0WU
DBTRG-05MG NELab4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwM{iwOVQh|ryP NWnWXnVmW0GQR1XS
SK-MEL-24 NYrTZ3ZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7IR4hYUUN3ME2wMlM6PzlzIN88US=> M{nMdnNCVkeHUh?=
8305C MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vDTGlEPTB;MD6zPVc6OyEQvF2= NYPFdG93W0GQR1XS
OVCAR-4 M3TQbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPMfnlPUUN3ME2wMlQyPTh4IN88US=> MXjTRW5ITVJ?
HLE M2PDNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnR[ZJKUUN3ME2wMlQyQDZizszN M{f5enNCVkeHUh?=
NCI-H747 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfTUJNuUUN3ME2wMlQzOTN5IN88US=> NWjlfYN3W0GQR1XS
SW780 NGDpT4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PFWmlEPTB;MD60NlM1PiEQvF2= NHXRSlNUSU6JRWK=
KYSE-150 Mli4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwNEK0NVUh|ryP MWLTRW5ITVJ?
H4 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTOTWM2OD1yLkSyOFUyKM7:TR?= MX;TRW5ITVJ?
SW1088 NIP3fW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwNESzPUDPxE1? NUD4eY5xW0GQR1XS
SF268 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHSPHZ4UUN3ME2wMlQ1QDZizszN NEPkTGFUSU6JRWK=
RT4 NYP4cmlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwNEWxNVEh|ryP NIW4XZVUSU6JRWK=
NCI-H522 MmnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPPbW5KSzVyPUCuOFUzPyEQvF2= MmT6V2FPT0WU
LCLC-97TM1 NGjZT5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3m5eGlEPTB;MD60OlE6PSEQvF2= NG\FTZpUSU6JRWK=
CAL-39 MknZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwNE[1NVkh|ryP Mo\PV2FPT0WU
CAL-120 NVu4fpU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jTW2lEPTB;MD60O|Y1OyEQvF2= NXT3[HdjW0GQR1XS
ESS-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PtXmlEPTB;MD60O|gzOSEQvF2= NIrqNJRUSU6JRWK=
KARPAS-45 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3IN2hKSzVyPUCuOFg6OzNizszN MYjTRW5ITVJ?
DU-4475 NXHpTXJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLwXnRKSzVyPUCuOFk2OTFizszN NH;lT|ZUSU6JRWK=
VMRC-RCZ MoG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PQeWlEPTB;MD60PVkxPCEQvF2= M{LodHNCVkeHUh?=
HOS MnHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M36zVWlEPTB;MD61NFM3PSEQvF2= NW\sdpV3W0GQR1XS
MOLT-16 MnvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLwPHFKSzVyPUCuOVE5ODhizszN M3Tkd3NCVkeHUh?=
RPMI-6666 M{nkOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13yVWlEPTB;MD61NlE{PSEQvF2= M4H1enNCVkeHUh?=
K052 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlr3TWM2OD1yLkWyNVQh|ryP NHLrOIFUSU6JRWK=
EHEB MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwNUKxPFIh|ryP NFnF[VlUSU6JRWK=
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HT-1376 M2r3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4qxWWlEPTB;MD64OlA2OSEQvF2= NEDrbm9USU6JRWK=
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NCI-H1581 MkT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWO0fnNUUUN3ME2wMlg6Ojl5IN88US=> MYHTRW5ITVJ?
HuCCT1 NXLldXVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLWU|hbUUN3ME2wMlg6PTR6IN88US=> MlXtV2FPT0WU
BB30-HNC NUC3clRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M122bGlEPTB;MD65NlQ3QSEQvF2= M{e2fHNCVkeHUh?=
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HL-60 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjycI1KSzVyPUGuNFA6PyEQvF2= NFLNWo9USU6JRWK=
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CAL-54 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnrRnNkUUN3ME2xMlA{QTV7IN88US=> Mmr0V2FPT0WU
DU-145 MmX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTFwMEiwO|Mh|ryP M3PTUHNCVkeHUh?=
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IMR-5 NY[2bIp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfYS3p2UUN3ME2xMlE3QTN4IN88US=> MVXTRW5ITVJ?
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MKN28 M{H5bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3VS|RMUUN3ME2xMlI2PjN4IN88US=> MX7TRW5ITVJ?
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ME-180 NYna[YU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXqOo9pUUN3ME2xMlM4QTl|IN88US=> NIrqb2RUSU6JRWK=
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SIMA M{Pjbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTFwNEi2PFch|ryP MWXTRW5ITVJ?
NCI-H1770 M3jMVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTFwNUKwOVQh|ryP NV:2enBKW0GQR1XS
ONS-76 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDFTWM2OD1zLkWyN|EyKM7:TR?= NV3jRnl4W0GQR1XS
LB771-HNC MoraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13Yd2lEPTB;MT61N|kxPiEQvF2= M33JXXNCVkeHUh?=
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MC-CAR NYfMcGpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonRTWM2OD1zLkW4OlY{KM7:TR?= MXHTRW5ITVJ?
D-336MG M{LHd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI[yWZBKSzVyPUGuOlI6PCEQvF2= MYDTRW5ITVJ?
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Calu-1 NHfrcGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYj0ZYtDUUN3ME2xMlY2Ozh4IN88US=> MUTTRW5ITVJ?
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A101D MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTFwNk[3PFEh|ryP NEXKOmlUSU6JRWK=
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RPMI-2650 M1\VT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXMTWM2OD1zLkeyO|E6KM7:TR?= M3fBWnNCVkeHUh?=
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NCI-H2009 NIHoS5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XWemlEPTB;MT63PVczOSEQvF2= M2K1NHNCVkeHUh?=
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D-542MG NHrkdHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7XeWFKSzVyPUGuPFU5PTFizszN M2TRNXNCVkeHUh?=
KNS-42 NVr1WotUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPnNYd1UUN3ME2xMlg3OjZ4IN88US=> MXjTRW5ITVJ?
NCI-H2452 MnfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\6fFlKSzVyPUGuPFkxPzRizszN NHHqbpZUSU6JRWK=
SK-MEL-2 Mo\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3w[VJOUUN3ME2xMlkxOjdzIN88US=> NY\KSYZ{W0GQR1XS
OVCAR-5 NXXNWphmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPSTWM2OD1zLkmwOlc2KM7:TR?= MWLTRW5ITVJ?
SNG-M MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXFXGxKSzVyPUGuPVU5PThizszN NFzJVmpUSU6JRWK=
A673 NXHFPIZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4D4Z2lEPTB;MT65O|UyPiEQvF2= NF7BVWhUSU6JRWK=
L-428 NVjlelZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmn0TWM2OD1zLkm5NVc6KM7:TR?= NGqwUFRUSU6JRWK=
KM-H2 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\lblljUUN3ME2yMlAyODlizszN NVfIbVI6W0GQR1XS
MC-IXC M13ob2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTJwMEKyO|Mh|ryP NYPrd|dlW0GQR1XS
COLO-678 Mkf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTJwMESyNFch|ryP Mn7rV2FPT0WU
MEL-JUSO MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHSR2NZUUN3ME2yMlA4QDVzIN88US=> NWLaUJJYW0GQR1XS
HCC38 MmntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlG0TWM2OD1{LkC4OFM{KM7:TR?= M2fsWXNCVkeHUh?=
UACC-62 NELH[o9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkj3TWM2OD1{LkC4PFU2KM7:TR?= MYHTRW5ITVJ?
OAW-42 NUC1eVZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7z[lRKSzVyPUKuNFk4OTFizszN MXfTRW5ITVJ?
LB996-RCC NIf1[JRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HxbmlEPTB;Mj6xN|gyPyEQvF2= NHLMNXpUSU6JRWK=
COR-L105 M{ezXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPyZVd6UUN3ME2yMlE3Ozd|IN88US=> NG\qN|FUSU6JRWK=
RCC10RGB M1jXTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTJwMUi1O|Yh|ryP MYfTRW5ITVJ?
A431 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnNTWM2OD1{LkG5NFE6KM7:TR?= Mn3XV2FPT0WU
NCI-H292 MoXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2L3e2lEPTB;Mj6yN|k2OSEQvF2= Mm\PV2FPT0WU
SK-UT-1 NGeyRXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LRfmlEPTB;Mj6zN|E5PCEQvF2= M4PWTXNCVkeHUh?=
PANC-08-13 NELXWFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTJwM{OyN|Uh|ryP MULTRW5ITVJ?
ST486 MkXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PGU2lEPTB;Mj60NVA1QCEQvF2= MYnTRW5ITVJ?
SJSA-1 M3zFT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnDTWM2OD1{LkSxNlcyKM7:TR?= NXfLT2pUW0GQR1XS
RKO MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTJwNEKwNlkh|ryP MkPzV2FPT0WU
NCI-H1793 Mof0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorFTWM2OD1{LkS0NFI6KM7:TR?= NXT4XXlFW0GQR1XS
639-V NHS5TXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTJwNEWzPFIh|ryP Mn62V2FPT0WU
ES3 MknJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfaUYVKSzVyPUKuOFk4OzdizszN M2f2PHNCVkeHUh?=
NCI-H1792 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDZR5RKSzVyPUKuOVY5OjZizszN MWnTRW5ITVJ?
NCI-H1651 M4X1U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HzSWlEPTB;Mj61PFIyKM7:TR?= NIW1NW9USU6JRWK=
SN12C MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXhTWM2OD1{LkW4OFg4KM7:TR?= M{HNfHNCVkeHUh?=
COLO-679 MlTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUC4dGxsUUN3ME2yMlU5PjB3IN88US=> M2D5cXNCVkeHUh?=
U-118-MG NInVWpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3q2[GlEPTB;Mj61PFg4OiEQvF2= NF30cWFUSU6JRWK=
Ramos-2G6-4C10 M3fqOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7j[HFKSzVyPUKuOlQ5ODdizszN MkP5V2FPT0WU
HCT-15 NUC0cmpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHsPHhKSzVyPUKuOlg4QTJizszN M3XLWnNCVkeHUh?=
MDA-MB-157 NFrFUXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLSTWM2OD1{LkewO|Q4KM7:TR?= M{e4bXNCVkeHUh?=
K5 NXj2PIw5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfwTWM2OD1{LkexPFQ2KM7:TR?= NGfIcWJUSU6JRWK=
MKN45 NXHwTnd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3TVYNYUUN3ME2yMlc{OzZ4IN88US=> NFj2SXhUSU6JRWK=
DMS-273 NUPvXWdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJwN{W2N|Ih|ryP NH\VUoJUSU6JRWK=
C8166 M3ThZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLxXIxyUUN3ME2yMlc5PTF|IN88US=> NHvkPFZUSU6JRWK=
Calu-3 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrsUnhoUUN3ME2yMlc5QTZ7IN88US=> M2nDVXNCVkeHUh?=
SNB75 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDDTWM2OD1{Lki4OVM2KM7:TR?= NHG2S5ZUSU6JRWK=
BFTC-905 NFG3[ZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2C0dmlEPTB;Mj65NFE6OSEQvF2= NHz6dIVUSU6JRWK=
C-4-II MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTJwOUGzOVMh|ryP M2jOdXNCVkeHUh?=
MS-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Xh[GlEPTB;Mj65Olc3QSEQvF2= M1[x[3NCVkeHUh?=
A375 MnfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvKXVJWUUN3ME2zMlA5OTh2IN88US=> M2DrWXNCVkeHUh?=
KYSE-70 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTNwMEi4PFIh|ryP M3;JNHNCVkeHUh?=
KYSE-510 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTEN5RqUUN3ME2zMlExQTl3IN88US=> M2LNUnNCVkeHUh?=
LN-405 NXnWc5lsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTNwMUO1NVgh|ryP NUnqdJE1W0GQR1XS
BOKU MkHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnTcGVoUUN3ME2zMlE1OjV4IN88US=> MU\TRW5ITVJ?
TE-10 M1\Ee2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX[1b|V2UUN3ME2zMlE4OzZ{IN88US=> NG\LUolUSU6JRWK=
MKN1 NXnKTW4{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\wVIVKSzVyPUOuNVg1QDNizszN NVvMUWZ2W0GQR1XS
M059J MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLod3RnUUN3ME2zMlIxOTd|IN88US=> NXLhe5YzW0GQR1XS
GOTO NEjQR4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LCUWlEPTB;Mz6yNlA{QSEQvF2= NGe5TWVUSU6JRWK=
DK-MG M4f4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTRbnJKSzVyPUOuNlU6PzZizszN NETsWWtUSU6JRWK=
NCI-H727 NF22b3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWL2PIJ4UUN3ME2zMlI3PThizszN M{WxOXNCVkeHUh?=
NB12 NEDZenhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTNwM{OyNlQh|ryP MWXTRW5ITVJ?
DOK NFnqdG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTNwM{[xPFYh|ryP M4DzW3NCVkeHUh?=
KYSE-410 NHPtXpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7ETWM2OD1|LkO2Nlg4KM7:TR?= NGnoPZFUSU6JRWK=
AM-38 NV;CUohrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfrUVhKSzVyPUOuN|gxPTFizszN MWTTRW5ITVJ?
GR-ST M1vSfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnFOYdKSzVyPUOuOFU4OzJizszN NEXubVhUSU6JRWK=
D-247MG NIHnVHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3BXJBKSzVyPUOuOFgzPjNizszN MmK3V2FPT0WU
TE-8 NEL0VZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTjTWM2OD1|LkS5N|M{KM7:TR?= M1LHSXNCVkeHUh?=
LS-411N MkLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfKe5lHUUN3ME2zMlQ6Pjl{IN88US=> M1;1R3NCVkeHUh?=
SK-MES-1 NE\uPW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1SzTGlEPTB;Mz61OlQ{OyEQvF2= MWLTRW5ITVJ?
SF295 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TqNWlEPTB;Mz62NVU2OiEQvF2= MWPTRW5ITVJ?
SK-MEL-30 NG\0U2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;VcWwxUUN3ME2zMlY2QTJzIN88US=> MnewV2FPT0WU
LB2241-RCC MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDoU|NKSzVyPUOuOlYzPiEQvF2= NWnmNnZbW0GQR1XS
PC-14 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7Kd|J6UUN3ME2zMlY3PDN5IN88US=> MlzzV2FPT0WU
EW-7 Mnr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\MTWM2OD1|Lk[3Olk{KM7:TR?= MX\TRW5ITVJ?
NMC-G1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3mdYJ{UUN3ME2zMlcyQDN5IN88US=> MofRV2FPT0WU
TE-441-T NYX6ZYV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPXVXliUUN3ME2zMlc{ODJ6IN88US=> M1fOe3NCVkeHUh?=
NCI-H1618 Mm\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DBcWlEPTB;Mz64NVg4PSEQvF2= NXTsXphjW0GQR1XS
PANC-03-27 MnXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PZUGlEPTB;Mz64NVkyPiEQvF2= NXj6VmtRW0GQR1XS
NCI-H2228 NX\qN4NPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWeyVVFZUUN3ME2zMlg{OTJ4IN88US=> NFnZbYxUSU6JRWK=
CAPAN-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{K0bmlEPTB;Mz64O|AxQSEQvF2= NVn4Nm13W0GQR1XS
KLE M{\HSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPzdFVKSzVyPUOuPVA3PyEQvF2= MXnTRW5ITVJ?
Becker NX;0eoU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPnc2JKSzVyPUOuPVI5PDlizszN MWrTRW5ITVJ?
SK-PN-DW MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzuUm5KSzVyPUSuNFc6PzRizszN MkX2V2FPT0WU
Hs-578-T MlyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\Fd|BNUUN3ME20MlA5OzB4IN88US=> MXTTRW5ITVJ?
RS4-11 NHzwVHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7ETWM2OD12LkGxNlU2KM7:TR?= NUflOY1kW0GQR1XS
D-502MG NVrLSmd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\Jd3hKSzVyPUSuNVY6QTdizszN MVzTRW5ITVJ?
GI-1 M2DrdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPjO3VKSzVyPUSuNlgzQTlizszN MlfiV2FPT0WU
NCI-H209 M4G2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXxTJJKSzVyPUSuN|M4QCEQvF2= M2rJR3NCVkeHUh?=
SK-OV-3 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\vV4twUUN3ME20MlQ5OTR7IN88US=> MV\TRW5ITVJ?
LOUCY MkfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTRwNEi0N|Ih|ryP MoDXV2FPT0WU
NCI-H69 Mo\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTRwNUG3PVMh|ryP M1;LS3NCVkeHUh?=
SCC-9 MlOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LFfWlEPTB;ND61N|E4OiEQvF2= M1rOfHNCVkeHUh?=
NCI-H526 NELr[JRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELNXnJKSzVyPUSuOVkzQTNizszN NILRRmZUSU6JRWK=
NCI-H2170 NVTtb5NnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\M[JZKSzVyPUSuOlY4PzFizszN NE[2S5hUSU6JRWK=
SR NGq1ZXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mly0TWM2OD12LkewNFQ5KM7:TR?= NHLqeFRUSU6JRWK=
CMK MkHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXsTWM2OD12LkeyNVAyKM7:TR?= NFfYTpdUSU6JRWK=
COLO-829 M4njOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTRwN{ewOFMh|ryP MVfTRW5ITVJ?
HuO-3N1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LDO2lEPTB;ND64N|I5OSEQvF2= NHS4cpBUSU6JRWK=
5637 MofGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;TN2lEPTB;ND65NFQ5PyEQvF2= M333ZXNCVkeHUh?=
A253 M4nDeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfrc|ZxUUN3ME20Mlk4PzB6IN88US=> Mlv2V2FPT0WU
NB10 Mmf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nKXmlEPTB;NT6wO|Q6PyEQvF2= MUTTRW5ITVJ?
SF539 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoL3TWM2OD13LkC5PVU6KM7:TR?= NXzDW|E2W0GQR1XS
HAL-01 NW\XR3U6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vOU2lEPTB;NT6xOFY1PSEQvF2= NHS5XFZUSU6JRWK=
MHH-ES-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PDdWlEPTB;NT6xOlkzPSEQvF2= NX;IcWN4W0GQR1XS
DEL MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXj3[YNWUUN3ME21MlI4PTh{IN88US=> M1:zO3NCVkeHUh?=
NCI-H1299 NF3XTphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT6co9lUUN3ME21MlM2ODB5IN88US=> NI\2XlRUSU6JRWK=
ChaGo-K-1 NE[wNHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rUdmlEPTB;NT6zOVExPyEQvF2= M1LMXXNCVkeHUh?=
HMV-II NX;USZhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fDRWlEPTB;NT6zPVQ{KM7:TR?= MlXqV2FPT0WU
NB69 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnP[VFKSzVyPUWuN|k3OzFizszN MYrTRW5ITVJ?
NCI-H1882 NVLoVHVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmThTWM2OD13LkSzN|Y1KM7:TR?= MXLTRW5ITVJ?
SNU-475 NEOwSnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jPUGlEPTB;NT60O|E4OSEQvF2= M2PmRXNCVkeHUh?=
RXF393 M3\ZR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rRN2lEPTB;NT60PFQ6PCEQvF2= MmK1V2FPT0WU
CAL-51 NYHqcXRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTVwNkK4OVMh|ryP MWLTRW5ITVJ?
SW1573 MoH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{mxR2lEPTB;NT62N|U{PCEQvF2= MnPKV2FPT0WU
GCT M2DQdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTVwN{W5Nlkh|ryP NXvMRWV5W0GQR1XS
COR-L88 M{XoUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTVwN{[4OFYh|ryP M4jh[3NCVkeHUh?=
MDA-MB-134-VI MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fY[GlEPTB;NT64O|U{PiEQvF2= NXz1SWhnW0GQR1XS
NB5 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvZUVZDUUN3ME21MlkzPDRizszN MYHTRW5ITVJ?
GMS-10 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTVwOU[4OlEh|ryP NXT2cItmW0GQR1XS
CHP-212 NX;yUlZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXWTVFTUUN3ME22MlQ5OjZ5IN88US=> MmrMV2FPT0WU
TE-11 M4C0dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTZwNUWxPFIh|ryP MkT1V2FPT0WU
SW962 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTrTWM2OD14Lk[1O|c1KM7:TR?= MlvGV2FPT0WU
MZ2-MEL NYjWOHBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\SXZVNUUN3ME22MlgzODFzIN88US=> MmDsV2FPT0WU
C-33-A NED1WIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkD5TWM2OD14LkmxOlg5KM7:TR?= MoDPV2FPT0WU
IGR-1 NFOzNm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TUdWlEPTB;Nj65O|gzPiEQvF2= M{KwZnNCVkeHUh?=
MOLT-4 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzOTWM2OD15LkG1OFA3KM7:TR?= MVjTRW5ITVJ?
NCI-H1650 M{jkb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnX2TWM2OD15LkK3NFQ3KM7:TR?= MYPTRW5ITVJ?
AsPC-1 NYjtT5dnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjYWpA2UUN3ME23MlI5PjB3IN88US=> MnL5V2FPT0WU
SNU-C2B NVX1cnZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVj5R4dkUUN3ME23MlI6PTdzIN88US=> MnPIV2FPT0WU
MKN7 NHvleXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLKTWM2OD15LkO3NlM2KM7:TR?= MXXTRW5ITVJ?
SW620 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnL4TWM2OD15LkO4NlA2KM7:TR?= MUPTRW5ITVJ?
SK-MEL-28 Mk[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzlZo5KUUN3ME23MlQxPzl6IN88US=> Mo\YV2FPT0WU
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COLO-792 Mn:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTDVWp{UUN3ME2yNk44OTFzIN88US=> NF;FSohUSU6JRWK=
CAL-62 NETkV49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUGzOpBuUUN3ME2yNk44PTF5IN88US=> NHS0T5pUSU6JRWK=
HCE-T MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTJ{Lki2NFYh|ryP NUOyPI1OW0GQR1XS
BB65-RCC M4THW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{P3VGlEPTB;MkOuNFM1PCEQvF2= MoHzV2FPT0WU
SiHa NIXDPG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NET6UodKSzVyPUKzMlM6PjhizszN NFzyO49USU6JRWK=
NCI-H2081 Mo\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3oTWM2OD1{ND6wOlQyKM7:TR?= MmLiV2FPT0WU
U251 NEG0dlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HpXWlEPTB;MkSuNFY3QCEQvF2= MWDTRW5ITVJ?
LoVo MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJ2LkmyPFIh|ryP NWPoSppqW0GQR1XS
GCIY MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37KUWlEPTB;MkWuNlg4PyEQvF2= MlPmV2FPT0WU
NUGC-3 MkmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTJ3LkOzNVYh|ryP NYXIXnM5W0GQR1XS
LNCaP-Clone-FGC MnTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{flS2lEPTB;MkWuN|Q6QCEQvF2= M3H5VXNCVkeHUh?=
PA-1 NHfaUmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3i[4tKSzVyPUK1MlY5OzNizszN NXLRPI9HW0GQR1XS
OE33 M17EZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHY[HRKSzVyPUK1MlY5PTNizszN MoTBV2FPT0WU
HT-29 NEL5N3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTJ3Lke4O|kh|ryP MVjTRW5ITVJ?
RCM-1 MmrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrCbnBsUUN3ME2yOU46PjV4IN88US=> MVXTRW5ITVJ?
NCI-H1522 MmKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTqZo1NUUN3ME2yOU46QTFzIN88US=> NInFW2VUSU6JRWK=
LB373-MEL-D NX3wUHBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17Dc2lEPTB;Mk[uNVcxQCEQvF2= MX3TRW5ITVJ?
NCI-H1436 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\ETJJQUUN3ME2yOk4zPzN6IN88US=> NEX5cVZUSU6JRWK=
COLO-824 NIf5S5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHoWHZUUUN3ME2yOk41ODB{IN88US=> MVvTRW5ITVJ?
CP50-MEL-B NX\FXVg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTJ4LkW2O|Uh|ryP NYrPOFY6W0GQR1XS
EGI-1 NWDZblhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTJ5LkK2PVgh|ryP MoPWV2FPT0WU
LAN-6 NUPsNlJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTJ5LkO1PVgh|ryP NU\tOmtXW0GQR1XS
GAK M17VTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF6ze4hKSzVyPUK3MlQzOjVizszN MYnTRW5ITVJ?
MDA-MB-175-VII NHfyOYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYWzS2pWUUN3ME2yO{42ODV|IN88US=> NVTNPGY6W0GQR1XS
JVM-2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\4TWM2OD1{Nz62OlIzKM7:TR?= M33UdXNCVkeHUh?=
UACC-257 NGPzNGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTJ5Lk[4O|gh|ryP Mnu1V2FPT0WU
SW1783 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2P6eGlEPTB;MkeuO|c5OyEQvF2= NUfvXI12W0GQR1XS
HT-3 NFzMVYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTJ6LkKxOlYh|ryP MlPuV2FPT0WU
RL NIq0eZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHId4ZKSzVyPUK4MlU6OTFizszN MmXGV2FPT0WU
TK10 NX;4cYw5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJ6Lk[1N|Uh|ryP NXzVcZQ5W0GQR1XS
HT55 MorkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\ycmlEPTB;MkmuNFU3PSEQvF2= NV3j[FJKW0GQR1XS
BT-20 MkHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\ZOYFXUUN3ME2yPU4xPTh4IN88US=> NV;YeYt7W0GQR1XS
TGBC24TKB NV62b|RYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTJ7LkG4N|Eh|ryP NU\pU|VrW0GQR1XS
HSC-2 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJ7LkOwNFEh|ryP Mn\BV2FPT0WU
COLO-205 M13B[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTJ7LkO5OFQh|ryP MXHTRW5ITVJ?
GT3TKB NUPDVndyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTJ7Lk[4O|ch|ryP NYDTdFR[W0GQR1XS
T47D MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fVPGlEPTB;MkmuPFU5OiEQvF2= MoHjV2FPT0WU
OMC-1 NF7nUmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPocpNVUUN3ME2zNE4yQTF7IN88US=> NIfCNY5USU6JRWK=
PFSK-1 NUO2b2V1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nkXmlEPTB;M{GuNlY2QSEQvF2= Mn3DV2FPT0WU
JEG-3 NIW0RXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVWzR3dUUUN3ME2zNU4{PTZzIN88US=> NHy1O3JUSU6JRWK=
RD NUXl[mpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDlTWM2OD1|MT61NVE2KM7:TR?= NGTtTVlUSU6JRWK=
NCI-H64 M3fxZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEK0eYNKSzVyPUOyMlQyPzlizszN NH;FPHFUSU6JRWK=
DMS-114 M1jBUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4S3RmlEPTB;M{KuOFE5OiEQvF2= MkO3V2FPT0WU
NCI-H661 NXrUTIlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;icVhJUUN3ME2zNk43PTBzIN88US=> MXrTRW5ITVJ?
CAL-148 MnqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHqwNWtKSzVyPUOyMlY3PjVizszN MWfTRW5ITVJ?
HuP-T3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTN{LkmzN|gh|ryP MULTRW5ITVJ?
ES4 MofrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13Gd2lEPTB;M{OuNVcxPSEQvF2= Ml;EV2FPT0WU
Ca9-22 NU[4S5V4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTN|LkS2NFEh|ryP NGToSYVUSU6JRWK=
LP-1 NFH2[VBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTN2LkC5JO69VQ>? M2DFT3NCVkeHUh?=
AU565 MoDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTN2LkWwOlkh|ryP MkjmV2FPT0WU
MDA-MB-453 NHLQOY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3OxZWlEPTB;M{WuNVQzPiEQvF2= NUXwe4VZW0GQR1XS
SNU-C1 NWX4R29yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\XbWp[UUN3ME2zOU4yPzFizszN MkTEV2FPT0WU
SW13 M2rKWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnRNpNwUUN3ME2zOU41ODd4IN88US=> NV3lNo85W0GQR1XS
NCI-H2122 NYPzNmdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PN[WlEPTB;M{WuOVU6QCEQvF2= NXfmOVFLW0GQR1XS
NCI-H1395 NVPnXnF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTN3Lk[2PVEh|ryP NVvO[VNrW0GQR1XS
J-RT3-T3-5 M2fUbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvMW4NKSzVyPUO2MlAzQTRizszN MlT5V2FPT0WU
COR-L279 M3PmUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\DO3Y2UUN3ME2zOk4yQThzIN88US=> NV75ZYF[W0GQR1XS
ATN-1 NYe1XmRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDiOGpKSzVyPUO2Mlg2OTZizszN NVX6T49iW0GQR1XS
HCC2998 MlvUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;KTWM2OD1|Nj64OVcyKM7:TR?= NGPrbVhUSU6JRWK=
UM-UC-3 NF7wNJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV61fmFDUUN3ME2zOk45Pjd3IN88US=> NHvsNVJUSU6JRWK=
DV-90 MnnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfZ[4V5UUN3ME2zOk46ODZ5IN88US=> MYXTRW5ITVJ?
ES8 Mk[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknXTWM2OD1|Nj65N|E5KM7:TR?= NHfD[VJUSU6JRWK=
YAPC NWLYV3N5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHaTWM2OD1|Nj65OlU1KM7:TR?= NHXFW|hUSU6JRWK=
HCC1599 M{LtZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2WzNGlEPTB;M{euNVYyQCEQvF2= NYHmOHE6W0GQR1XS
UMC-11 M4K4dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXtR41tUUN3ME2zO{4zPTB|IN88US=> M3vJVHNCVkeHUh?=
THP-1 NFvE[ZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDxRYl2UUN3ME2zO{4zQDZ6IN88US=> MWrTRW5ITVJ?
OCUB-M M{fl[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETQPIVKSzVyPUO3MlI5QTFizszN MYnTRW5ITVJ?
NCI-H1693 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTN5LkOyN|Mh|ryP MUHTRW5ITVJ?
NCI-H345 NHrET|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTN5LkO2NlQh|ryP NFjaNVRUSU6JRWK=
COLO-800 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnm3TWM2OD1|Nz61Olch|ryP M4i3dnNCVkeHUh?=
COLO-320-HSR M1jBXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLFfXdKUUN3ME2zPE4{PDl{IN88US=> MXrTRW5ITVJ?
NCI-H596 NUTDb4F{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojlTWM2OD1|OD60OFg6KM7:TR?= NIfLfGNUSU6JRWK=
NCI-H187 NVeyUnZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nROWlEPTB;M{iuO|M1PCEQvF2= NXTSPXM5W0GQR1XS
ECC4 NHP6fplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HldmlEPTB;M{muNFgyPCEQvF2= NVn4dYE{W0GQR1XS
KP-4 NUDnPHU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlr5TWM2OD1|OT6xNlM2KM7:TR?= MUXTRW5ITVJ?
NCI-H2227 Mn;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DDWWlEPTB;M{muN|k1QSEQvF2= M{LY[3NCVkeHUh?=
22RV1 NXHOeHlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTN7LkizPVgh|ryP Mk\kV2FPT0WU
SAS NXGzSJJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFP1WodKSzVyPUSwMlA6PiEQvF2= NIDuZYxUSU6JRWK=
PANC-10-05 NF3UW2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTRyLkG4Nlgh|ryP NUHIWG9kW0GQR1XS
MDA-MB-468 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnnSZZKSzVyPUSwMlU{PDZizszN MnixV2FPT0WU
RPMI-7951 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrGbndKSzVyPUSxMlIxPzVizszN MULTRW5ITVJ?
BB49-HNC MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTRzLkKxO|kh|ryP MmnHV2FPT0WU
23132-87 NFH6TXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jRTWlEPTB;NEGuNlc{OiEQvF2= MYPTRW5ITVJ?
HCC1569 NVzhdmRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnmT29xUUN3ME20NU4zQDh3IN88US=> M{\3dHNCVkeHUh?=
CP66-MEL Ml2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PMT2lEPTB;NEKuNVg5PiEQvF2= MXHTRW5ITVJ?
K-562 NH7iOHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTR{LkK4OVQh|ryP M2T0OXNCVkeHUh?=
OCI-AML2 M3nWbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrFTWM2OD12Mj64PVc1KM7:TR?= Mm\sV2FPT0WU
SW756 NGizUphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF6zNpBKSzVyPUSzMlA{QDhizszN M1fyVXNCVkeHUh?=
M14 NFTsTmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWH5VJR2UUN3ME20N{4{OTh7IN88US=> MXTTRW5ITVJ?
NCI-H1623 NELFWFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{T6bmlEPTB;NEOuOFY1KM7:TR?= Mn21V2FPT0WU
KNS-81-FD MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvvO3R[UUN3ME20N{44PjJizszN NVOxU255W0GQR1XS
TGBC1TKB M1y5Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7UbohRUUN3ME20N{46ODl7IN88US=> M2K5cnNCVkeHUh?=
RERF-LC-MS NHr5PYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LCWmlEPTB;NEOuPVI5OSEQvF2= MVrTRW5ITVJ?
PC-3 NY[zSJhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGj1coNKSzVyPUS0MlQ{PDdizszN MnnmV2FPT0WU
HuP-T4 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\vTo5KSzVyPUS0MlQ1PzRizszN NIT4T|JUSU6JRWK=
NCI-H510A MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\pfXRIUUN3ME20OE44ODhizszN M4rhe3NCVkeHUh?=
LB2518-MEL MnnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPnWIpyUUN3ME20OE44QTN5IN88US=> NELmXFFUSU6JRWK=
TE-5 M2XCe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFn2eYNKSzVyPUS1Mlk2QDFizszN NHfXOVNUSU6JRWK=
EW-24 MnXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTR4LkG3NlMh|ryP Ml;pV2FPT0WU
LB647-SCLC MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPlTWM2OD12Nj6yNVU2KM7:TR?= MkTQV2FPT0WU
NCI-H524 NFLyPI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7FTWM2OD12Nj63NVg2KM7:TR?= Ml3yV2FPT0WU
EW-11 Mmf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL0U5FEUUN3ME20Ok46Ozd|IN88US=> NHLwVG9USU6JRWK=
KALS-1 MmrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPoOHNVUUN3ME20O{4zODZ4IN88US=> M3jtOnNCVkeHUh?=
BT-474 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\iRYdKUUN3ME20O{41OjF4IN88US=> NXOwSIYzW0GQR1XS
SK-N-AS MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTLW4tNUUN3ME20O{45QDhizszN NFrXdIZUSU6JRWK=
HCC2157 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvBTWM2OD12OD6wO|Yh|ryP NHLTfJhUSU6JRWK=
HCC1954 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrncm5WUUN3ME20PE4yPzB2IN88US=> NIDHRWVUSU6JRWK=
FADU MoX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mme1TWM2OD12OD6zNFMyKM7:TR?= MmrCV2FPT0WU
S-117 M2fqXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[xTWM2OD12OD6zPFE2KM7:TR?= M3vYU3NCVkeHUh?=
LS-1034 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zIcWlEPTB;NEiuO|A3PyEQvF2= Mlq4V2FPT0WU
CAMA-1 NUTFO|R6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DTcGlEPTB;NEmuOVU1OyEQvF2= M4HLfHNCVkeHUh?=
LU-134-A MlzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTR7LkiwPFUh|ryP NWq2WWg4W0GQR1XS
NCI-H1838 MofvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTR7LkiwPFch|ryP MnfuV2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pSrc / Src / pPlcg / Plcg / pStat5 / Stat5 ; 

PubMed: 22781593     


In (B) inhibition of Src, Plcg and Stat5 was seen in MLNAF cell lines treated with Ponatinib; ZNF112 expresses ZMYM2–FGFR1, CEP2A and CEP5A cells express CEP110–FGFR1 and BBC2 expresses BCR–FGFR1.

pFGFR1(pY20) / FGFR1; 

PubMed: 22781593     


Western blot analysis, using various antibodies specific for downstream targets of FGFR1, demonstrates that Ponatinib inhibits the activation of Plcg and Src as a result of inhibiting the FGFR1 fusion kinase in human KG1 cells. 

cleaved caspase-3 / cleaved caspase-7 / BAX / Bcl-2; 

PubMed: 30959969     


Western blot analysis of cleaved caspase-3, cleaved caspase-7, Bax, Bcl-2, and β-Tubulin (control) in treated cells.

p-Rb(S807/811) / Rb / CDK4 / CDK6 / Cyclin D1 / CDK2 / Cyclin E1; 

PubMed: 30959969     


Western blot analysis of Rb/p-Rb, CDK4, CDK6, Cyclin D1, CDK2, Cyclin E1, and β-Tubulin (control) in the SK-Hep-1 and SNU-423 cells treated with ponatinib. 

RAD51; 

PubMed: 30959969     


The effect of ponatinib on the concentration of Rad51 in SK-Hep-1 and SNU-423 cells.

p-MEK / MEK / p-ERK / ERK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Mek and Erk. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

c-Jun / p-JNK(T183/Y185) / JNK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of JNK and c-Jun. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-p38 MAPK / p38 MAPK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of p38. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-JAK2 / JAK2 / p-STAT3 / STAT3; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Jak2, and Stat3. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

PI3K p85 / p-PI3K / p-PDK1 / PDK1 / p-mTOR / mTOR; 

PubMed: 30959969     


Effects of ponatinib on the protein concentration and phosphorylation of PI 3-kinase, PDK1, Akt, and mTOR in HCC cells. 

p-PDGFRα / PDGFRα; 

PubMed: 24472312     


Ponatinib inhibited phosphorylation of PDGFRα in a concentration-dependent manner. EOL-1 and BaF3-WT or -T674I FIP1L1-PDGFRα cells were exposed to escalating concentrations of ponatinib for 24 h.

PARP / Caspase-3 / Active Caspase-3; 

PubMed: 24472312     


The concentration- (for 24 h) and time-dependent (1 nM for EOL-1, 300 nM for BaF3-WT and -T674I FIP1L1-PDGFRα cells) cleavage of PARP and caspase-3 triggered by ponatinib was analyzed by immunoblotting.

AIF / Cyto C ; 

PubMed: 24472312     


Ponatinib elicited release of AIF and cytochrome c into the cytosol. Cells were treated with 1 nM ponatinib for the indicated durations and the cytosolic fraction was extracted with digitonin buffer. Levels of AIF and Cytochrome c (Cyto c) were detected by immunoblotting.

Mcl-1 / Survivin / Bcl-Xl / XIAP / Bax / Bcl-2 / Bim; 

PubMed: 24472312     


Immunoblotting of apoptosis-related proteins in CEL cells after treatment for 24 h.

β-catenin ; 

PubMed: 24472312     


Ponatinib concentration-dependently lowered β-catenin. EOL-1 cells were incubated with ponatinib for 24 h, and cytoplasmic and nuclear extracts were determined by immunoblotting.

β-catenin; 

PubMed: 24472312     


Analysis of β-catenin localization. EOL-1 cells were pretreated with 1 nM ponatinib for 24 h, immunofluorescence analysis was performed with anti-β-catenin. Nuclei were stained with 4,6-diamidino-2-phenylindole (DAPI). 

ABL; 

PubMed: 19878872     


In vitro [γ-32P]-ATP autophosphorylation of full-length (A) ABL or (B) ABLT315I kinase treated with AP24534, imatinib, nilotinib, or dasatinib. After incubation of tyrosine-dephosphorylated enzyme with the indicated inhibitor in the presence of [γ-32P]-ATP and separation by SDS-PAGE, signal intensity was measured by autoradiography.

22781593 30959969 24472312 19878872
Growth inhibition assay
Cell viability; 

PubMed: 30174789     


(A) Effect of Ponatinib on basal viability of HUVECs. The cells were treated with Ponatinib at indicated concentrations or 0.1% DMSO (vehicle control) for 24 h.

30174789
体内研究 Ponatinib抑制取自FLT3-ITD阳性AML病人的原代白血病细胞,而不抑制表达阴性FLT3的AML病人的白血病细胞。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
- 合并

激酶实验:

通过同质时间分辨荧光共振能量转移法(TR-FRET),使用纯化的人类野生型ABL激酶,T315I突变型ABL激酶,及生物素化的磷酸激酶底物肽: 生物素-EKKMAAEAIYAAPFAK-NH2,测定野生型ABL和T315I突变型ABL活性的抑制激酶反应在全LANCE激酶buffer (LKB)中进行,LKB包括20 mM NaHEPES(pH 为7.4), 0.1 mg ⁄ mL BSA, 1 mM ATP, 10 mM MgCl2, 及0.41 mM DTT,在提前用1% BSA(溶于PBS)包被的96孔板上4oC下过夜。用于激酶反应,Ponatinib稀释物和野生型ABL, T315I突变型ABL (40 pM), 及底物肽(50 nM), 在室温下温育1小时(T315I突变型ABL)或2小时(野生型ABL)。加入15 nM 抑制剂, 6 nM 铕标记的磷酸酪氨酸抗体(磷酸化位点在第66为酪氨酸上),及60 nM 别藻蓝素标记的链酶亲和素,终止反应。实验板在室温下黑暗温育20分钟,使用Wallac Victor2V读数器读取615和665nm处的荧光值。在孔中数据平均值中插入抑制剂的3倍连续稀释液,再读取665nm处荧光值,计算IC50值。
细胞实验:[1]
- 合并
  • Cell lines: Ba ⁄ F3细胞
  • Concentrations: 0-625 nM, 和0-10 µM
  • Incubation Time: 72小时
  • Method: Ba/F3细胞系按每孔4×103个细胞分布在96孔板上(4×103),和梯度浓度Ponatinib温育72小时。Ponatinib浓度范围为: 0-625 nM 作用于表达BCR-ABL细胞,0-10 µM 用于测定BCR-ABL阴性细胞。使用MTS实验测定细胞增殖,取三次平行实验平均值测定IC50值。
    (Only for Reference)
动物实验:[3]
- 合并
  • Animal Models: 皮下植入MV4-11细胞移植瘤(1×107,50%基质胶中) 的雌性CB.17 SCID鼠
  • Dosages: 每天处理一次,持续4周
  • Administration: 口服饲喂处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
1% CMC Na
30mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 532.56
化学式

C29H27F3N6O

CAS号 943319-70-8
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04160546 Recruiting Drug: Ponatinib 15 MG|Drug: Acetylsalicylic acid 100 MG Chronic Myeloid Leukemia Chronic Phase Fundacion CRIS de Investigación para Vencer el Cáncer|Incyte Biosciences UK|Apices Soluciones S.L. January 17 2020 Phase 2
NCT04070443 Recruiting Drug: Ponatinib|Drug: Imatinib Philadelphia Chromosome Positive CML|BCR-ABL Positive Chronic Myelogenous Leukemia Centre Leon Berard November 13 2019 Phase 2
NCT03934372 Recruiting Drug: Ponatinib Acute Myeloid Leukemia|Accelerated Phase Chronic Myeloid Leukemia|Blast Phase Chronic Myeloid Leukemia|Chronic Phase Chronic Myeloid Leukemia|Acute Lymphoblastic Leukemia|Acute Lymphocytic Leukemia|Leukemia|Lymphoma|Solid Tumors Incyte Biosciences International Sàrl|Incyte Corporation November 22 2019 Phase 1|Phase 2
NCT03895671 Recruiting Drug: Ponatinib|Drug: Azacitidine CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE|CHRONIC MYELOGENOUS LEUKAEMIA IN MYELOID BLAST CRISIS Versailles Hospital June 19 2019 Phase 2
NCT03690115 Recruiting Drug: Ponatinib 30 MG Leukemia Myeloid Acute Versailles Hospital December 12 2018 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID