Ponatinib (AP24534)

目录号：S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534)是一种新型有效的多靶点抑制剂，在无细胞试验中作用于Abl，PDGFRα，VEGFR2，FGFR1和Src，IC50分别为0.37 nM，1.1 nM，1.5 nM，2.2 nM和5.4 nM。

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RMB 819.31 现货
RMB 903.01 现货
RMB 3034.48 现货
RMB 7959.08 现货
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客户购买Selleck的此次产品后发表的文献31篇：

客户使用该产品的4个实验数据：

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

产品描述 Ponatinib (AP24534)是一种新型有效的多靶点抑制剂，在无细胞试验中作用于Abl，PDGFRα，VEGFR2，FGFR1和Src，IC50分别为0.37 nM，1.1 nM，1.5 nM，2.2 nM和5.4 nM。
靶点
Abl [1]
(Cell-free assay)		 PDGFRα [1]
(Cell-free assay)		 VEGFR2 [1]
(Cell-free assay)		 FGFR1 [1]
(Cell-free assay)		 c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外研究

Ponatinib是有效的可用于口服的多靶点激酶抑制剂，作用于野生型细胞,及T315I 突变细胞IC50分别为1.2和8.8nM。[1] Ponatinib抑制Ba/F3衍生细胞系的增殖。[2] Ponatinib作用于表达野生型或T315I突变型BCR-ABL的CML细胞系，有效抑制BCR-ABL调节的信号。Ponatinib阻断在细胞瘤筛选时产生抗性突变。[3] Ponatinib也抑制VEGFR和FGFR家族激酶，在体外抑制FLT3, KIT, FGFR1,和PDGFRa激酶活性时IC50分别为13, 13, 2, 和1 nM.[4]Ponatinib抑制全部4种RTKs磷酸化，存在剂量依赖性，IC50值为0.3到20 nM。然而，Ponatinib抑制表达野生型FLT3的RS4;11细胞时IC50>100 nM。
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NGTnN4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWW0W2d7UUN3ME2wMlAxODByMECzOVkh|ryP MYfTRW5ITVJ?
MV-4-11 MlXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3i0VWlEPTB;MD6wNFAxQTV4IN88US=> Mke4V2FPT0WU
MEG-01 NVzGVGozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjqTWM2OD1yLkCwNFEzQCEQvF2= NFTobGRUSU6JRWK=
LAMA-84 M3XpSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlT0TWM2OD1yLkCwNFE3PSEQvF2= MWHTRW5ITVJ?
CGTH-W-1 MoXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vxVmlEPTB;MD6wNFE3QSEQvF2= MlLTV2FPT0WU
KASUMI-1 NXe4SmpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMECyNVch|ryP NV3pRVNNW0GQR1XS
BE-13 NE\0cG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXaTWM2OD1yLkCwNlU6KM7:TR?= Ml7SV2FPT0WU
CTV-1 NU\5[IZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fGT2lEPTB;MD6wNFUzOSEQvF2= MmTMV2FPT0WU
NKM-1 M1rY[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NES3cYlKSzVyPUCuNFA3PTVizszN NVvON29wW0GQR1XS
MONO-MAC-6 M4XWOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPuTWM2OD1yLkCwPFM4KM7:TR?= M2n4NnNCVkeHUh?=
A204 NHHWOmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXXTWM2OD1yLkCxNlE5KM7:TR?= MV\TRW5ITVJ?
GDM-1 NGfXWoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLtTWM2OD1yLkCxPFM{KM7:TR?= NFTPbYNUSU6JRWK=
AN3-CA NV3WZpdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDUd4tuUUN3ME2wMlAyQDd|IN88US=> MnH6V2FPT0WU
BL-70 NVexcVFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TmNWlEPTB;MD6wNlE6QSEQvF2= MX7TRW5ITVJ?
Daudi MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fuPGlEPTB;MD6wNlU{PyEQvF2= MV3TRW5ITVJ?
KU812 NXXaR3U1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTxTWM2OD1yLkCyPFQ5KM7:TR?= M{TjUHNCVkeHUh?=
KG-1 NIXFTWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PO[mlEPTB;MD6wN|I6PCEQvF2= Mm\jV2FPT0WU
DOHH-2 NXLwenNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\Wd5JKSzVyPUCuNFQ5ODNizszN MV;TRW5ITVJ?
HuO9 M{DJdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NID6[WJKSzVyPUCuNFU1PDhizszN NX3pSpdvW0GQR1XS
EB2 M3jIPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnRVFVKSzVyPUCuNFU2PzZizszN NVuyW|ZMW0GQR1XS
G-402 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Gw[WlEPTB;MD6wOlM1OSEQvF2= MWHTRW5ITVJ?
SU-DHL-1 M{P5S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEe2V2xKSzVyPUCuNFY{PzlizszN NIny[WJUSU6JRWK=
NCI-H719 NEjoeGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXr[ldRUUN3ME2wMlA4QDh6IN88US=> NIW1eGFUSU6JRWK=
MLMA MkLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LTT2lEPTB;MD6wPVA3KM7:TR?= MnjzV2FPT0WU
KM12 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzaTWM2OD1yLkC5O|M4KM7:TR?= NHfX[I1USU6JRWK=
SUP-T1 NWf0TYRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHlTWM2OD1yLkC5PVgzKM7:TR?= NEPFTVRUSU6JRWK=
MZ1-PC NHnhcoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMUGzN|Yh|ryP NXv5foN7W0GQR1XS
MFE-296 NIX1W4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;lbZllUUN3ME2wMlEyQDN7IN88US=> NXj2R2hOW0GQR1XS
ALL-PO NUj0blMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmOxTWM2OD1yLkGyOFQ{KM7:TR?= MXLTRW5ITVJ?
GB-1 MlrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMUK1NVIh|ryP M1HiSXNCVkeHUh?=
SIG-M5 M4L1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzkTnY4UUN3ME2wMlE{OzdizszN NUW2NlI2W0GQR1XS
P30-OHK MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\BZY92UUN3ME2wMlE2Pjd{IN88US=> NIL4VGlUSU6JRWK=
NCI-H716 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEP3OnhKSzVyPUCuNVYzPjZizszN M4TS[3NCVkeHUh?=
MPP-89 NUjiS|JDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\tTWM2OD1yLkG2PVM{KM7:TR?= M2jDOnNCVkeHUh?=
SF126 NXXifnllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMUewOlMh|ryP NXq5VGNVW0GQR1XS
CTB-1 M{Xu[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMUezNVYh|ryP MWnTRW5ITVJ?
CA46 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\oTWM2OD1yLkG3OFg6KM7:TR?= MmHNV2FPT0WU
NCI-H520 MnXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrI[|FKSzVyPUCuNVc4OzJizszN M4e4S3NCVkeHUh?=
CAL-85-1 NV\sZ2Y{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nNOmlEPTB;MD6xO|kzPyEQvF2= MYfTRW5ITVJ?
NCI-H2342 NUXCXZJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfhemlKSzVyPUCuNVg2PzdizszN NHzaSJBUSU6JRWK=
697 M1XU[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnraTWM2OD1yLkG4PFcyKM7:TR?= M4m2UXNCVkeHUh?=
NY NEHRNndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEKzZ2dKSzVyPUCuNVkzQDdizszN MnP1V2FPT0WU
T98G MlXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH6yfYlKSzVyPUCuNVk{OThizszN MkTBV2FPT0WU
NCI-H1703 MknES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLiTWM2OD1yLkG5OlE2KM7:TR?= M1jFcXNCVkeHUh?=
NCI-H2087 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\hU2lEPTB;MD6yNFQ{QSEQvF2= NEPNeWtUSU6JRWK=
PF-382 M4ixPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMkC4O|Mh|ryP Mo\JV2FPT0WU
HCT-116 NWPwXGdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUf4[GR4UUN3ME2wMlIyODZ7IN88US=> NHrEXYtUSU6JRWK=
CAKI-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULweHdsUUN3ME2wMlIyPjZ4IN88US=> NWDBdYVWW0GQR1XS
CCF-STTG1 M{XZUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoP6TWM2OD1yLkKyOFc2KM7:TR?= NIHtUoRUSU6JRWK=
D-392MG NUn4PXo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELO[W1KSzVyPUCuNlMyPzdizszN M4\KeXNCVkeHUh?=
RT-112 M{T3NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMkO3PVUh|ryP MonEV2FPT0WU
MES-SA M3uwcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\RTWM2OD1yLkK0NVg4KM7:TR?= MVnTRW5ITVJ?
LC-2-ad NYPRSXJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2D1OWlEPTB;MD6yOFI3PSEQvF2= MWjTRW5ITVJ?
NOS-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nQPGlEPTB;MD6yOFM3PyEQvF2= M3frcnNCVkeHUh?=
NALM-6 Mn3IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF2zWo5KSzVyPUCuNlU2PDNizszN NYH4[WRjW0GQR1XS
TE-15 Mn3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2m0[2lEPTB;MD6yOlA6OSEQvF2= NIS1dpNUSU6JRWK=
786-0 NY\zW|ViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[4TWM2OD1yLkK2NlI5KM7:TR?= NEPRW3pUSU6JRWK=
IST-MES1 MkXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMk[4Nlkh|ryP MXHTRW5ITVJ?
KYSE-180 MnzES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HuXGlEPTB;MD6yOlg6OSEQvF2= MWnTRW5ITVJ?
YT MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvmbohVUUN3ME2wMlI3QTd2IN88US=> MYfTRW5ITVJ?
A427 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvEO5AyUUN3ME2wMlI4OjZ2IN88US=> NX\HeXp4W0GQR1XS
KYSE-450 Ml3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGP0WpdKSzVyPUCuNlc{OjlizszN MnjwV2FPT0WU
HuH-7 NHizZVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrxdmY3UUN3ME2wMlI4PzZ|IN88US=> MYDTRW5ITVJ?
CAS-1 NX:0fVF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrCTWM2OD1yLkK4N|A{KM7:TR?= MXfTRW5ITVJ?
KURAMOCHI M1fCbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHJNItvUUN3ME2wMlI5PDF7IN88US=> MVLTRW5ITVJ?
ACHN MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnRRZhKSzVyPUCuNlk{OjNizszN MWrTRW5ITVJ?
HGC-27 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHxUXlRUUN3ME2wMlI6OzV|IN88US=> M3\5fXNCVkeHUh?=
A172 NHHnN29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXmUoZZUUN3ME2wMlI6PTd5IN88US=> M{TmRnNCVkeHUh?=
SNU-449 NVG4dIxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LqUGlEPTB;MD6yPVk3PCEQvF2= NVH5b3E4W0GQR1XS
SW982 MmjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjNTWM2OD1yLkK5PVc5KM7:TR?= NGDKbXhUSU6JRWK=
EFO-21 NGnVenNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwM{C0NVEh|ryP NXnD[JBpW0GQR1XS
NCI-H2030 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDMTWM2OD1yLkOxNVY1KM7:TR?= M33y[3NCVkeHUh?=
HT-144 NUPwTGdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInQUIVKSzVyPUCuN|EzQCEQvF2= MX3TRW5ITVJ?
MFE-280 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfFfoVKSzVyPUCuN|E1PTNizszN NViwbHV[W0GQR1XS
SK-LU-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2X2UWlEPTB;MD6zNVQ3PiEQvF2= MlPJV2FPT0WU
NCI-H2052 M1LrSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LONWlEPTB;MD6zNVQ5PCEQvF2= MkixV2FPT0WU
SK-HEP-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfFTWM2OD1yLkOzN|Y5KM7:TR?= MV7TRW5ITVJ?
QIMR-WIL NXK5Z2VkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fFdWlEPTB;MD6zN|QzPCEQvF2= M37jbHNCVkeHUh?=
A2780 NFzYXW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXOTWM2OD1yLkO0N|A1KM7:TR?= M3r5V3NCVkeHUh?=
ACN M3rneGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDOS21KSzVyPUCuN|Q5PzNizszN NX;2RoxSW0GQR1XS
BxPC-3 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf1T2hZUUN3ME2wMlM1QTh7IN88US=> M36zTXNCVkeHUh?=
BCPAP Mli1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwM{[wNFEh|ryP NIH1PWFUSU6JRWK=
HOP-62 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvZTWM2OD1yLkO2NVA3KM7:TR?= MkSzV2FPT0WU
SW1710 NUDqRpZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTRR5RKSzVyPUCuN|Y1PTVizszN MXLTRW5ITVJ?
OPM-2 M3vyVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknxTWM2OD1yLkO2OFc{KM7:TR?= M3HaSHNCVkeHUh?=
DBTRG-05MG NGfjR2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHBWVVKSzVyPUCuN|gxPTRizszN MYTTRW5ITVJ?
SK-MEL-24 M4rON2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPVV29uUUN3ME2wMlM6PzlzIN88US=> NFfUVW9USU6JRWK=
8305C NHrCNYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrHdYZYUUN3ME2wMlM6Pzl|IN88US=> NHvye3ZUSU6JRWK=
OVCAR-4 MoO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml36TWM2OD1yLkSxOVg3KM7:TR?= NEPyO3VUSU6JRWK=
HLE MljsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrneYtKSzVyPUCuOFE5PiEQvF2= Mk\sV2FPT0WU
NCI-H747 MoLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULGSGtiUUN3ME2wMlQzOTN5IN88US=> NYTNO2htW0GQR1XS
SW780 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwNEKzOFYh|ryP MlHwV2FPT0WU
KYSE-150 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlOxTWM2OD1yLkSyOFE2KM7:TR?= Ml65V2FPT0WU
H4 NFHVVlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFH3bmJKSzVyPUCuOFI1PTFizszN MYrTRW5ITVJ?
SW1088 NGLv[GFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwNESzPUDPxE1? M1u1cnNCVkeHUh?=
SF268 M4SyWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXOUXpnUUN3ME2wMlQ1QDZizszN NUX4d2RQW0GQR1XS
RT4 M1rqN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTDTWM2OD1yLkS1NVEyKM7:TR?= MlzUV2FPT0WU
NCI-H522 MmPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwNEWyO{DPxE1? Mnz0V2FPT0WU
LCLC-97TM1 NEXwVWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HVeGlEPTB;MD60OlE6PSEQvF2= NFOxWFRUSU6JRWK=
CAL-39 MnzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwNE[1NVkh|ryP NXvmS2ZMW0GQR1XS
CAL-120 NVP6fGo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwNEe2OFMh|ryP MXPTRW5ITVJ?
ESS-1 NXXHcJFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoKxTWM2OD1yLkS3PFIyKM7:TR?= Ml3SV2FPT0WU
KARPAS-45 M1mxdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwNEi5N|Mh|ryP MVLTRW5ITVJ?
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SK-NEP-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTFwOEO3Olch|ryP MVvTRW5ITVJ?
D-542MG NHrrd4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nKd2lEPTB;MT64OVg2OSEQvF2= NFSxPXRUSU6JRWK=
KNS-42 NXnrd5ZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjVTWM2OD1zLki2NlY3KM7:TR?= NGe5NWpUSU6JRWK=
NCI-H2452 MlzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjW[INSUUN3ME2xMlg6ODd2IN88US=> M{LjU3NCVkeHUh?=
SK-MEL-2 NXLvcVNIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmi0TWM2OD1zLkmwNlcyKM7:TR?= MkfvV2FPT0WU
OVCAR-5 Ml7BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGiyO2ZKSzVyPUGuPVA3PzVizszN M3S0RnNCVkeHUh?=
SNG-M MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPYTWM2OD1zLkm1PFU5KM7:TR?= MYLTRW5ITVJ?
A673 M13Oe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkX3TWM2OD1zLkm3OVE3KM7:TR?= MkTWV2FPT0WU
L-428 MmHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnnNlNNUUN3ME2xMlk6OTd7IN88US=> NIPBXlFUSU6JRWK=
KM-H2 M3n0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHqWFUzUUN3ME2yMlAyODlizszN M3PiT3NCVkeHUh?=
MC-IXC NV3qUI9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHrdXVQUUN3ME2yMlAzOjd|IN88US=> NELxXG9USU6JRWK=
COLO-678 M4rJSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1[1Z2lEPTB;Mj6wOFIxPyEQvF2= NVjO[IVLW0GQR1XS
MEL-JUSO MlLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTJwMEe4OVEh|ryP M4Dm[3NCVkeHUh?=
HCC38 NI\aNYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjvOHR4UUN3ME2yMlA5PDN|IN88US=> Mo\JV2FPT0WU
UACC-62 NHGwbGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoOxTWM2OD1{LkC4PFU2KM7:TR?= NInh[pdUSU6JRWK=
OAW-42 MlLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4mwUGlEPTB;Mj6wPVcyOSEQvF2= MUnTRW5ITVJ?
LB996-RCC NGC1bnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7Hd4xrUUN3ME2yMlE{QDF5IN88US=> NUPNUpdNW0GQR1XS
COR-L105 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XEcWlEPTB;Mj6xOlM4OyEQvF2= M2fERXNCVkeHUh?=
RCC10RGB M3PIWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfKTWM2OD1{LkG4OVc3KM7:TR?= MWDTRW5ITVJ?
A431 M3PUXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUK1NoJkUUN3ME2yMlE6ODF7IN88US=> NUHYRodPW0GQR1XS
NCI-H292 MlrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIe5WodKSzVyPUKuNlM6PTFizszN MnuwV2FPT0WU
SK-UT-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{T3NWlEPTB;Mj6zN|E5PCEQvF2= NFj2UVNUSU6JRWK=
PANC-08-13 NHjWe4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHTRYtKSzVyPUKuN|MzOzVizszN MkHsV2FPT0WU
ST486 NXH2TY9UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTJwNEGwOFgh|ryP MV7TRW5ITVJ?
SJSA-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTJwNEGyO|Eh|ryP Mn;HV2FPT0WU
RKO Ml;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJwNEKwNlkh|ryP MmPYV2FPT0WU
NCI-H1793 NVzPN2JrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVj0fYNwUUN3ME2yMlQ1ODJ7IN88US=> M4LJVHNCVkeHUh?=
639-V M4PESWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHIV5lWUUN3ME2yMlQ2Ozh{IN88US=> NX3DfIZUW0GQR1XS
ES3 NIDKOW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDDOHJvUUN3ME2yMlQ6PzN5IN88US=> MnrwV2FPT0WU
NCI-H1792 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInvRYtKSzVyPUKuOVY5OjZizszN M{TLS3NCVkeHUh?=
NCI-H1651 MoLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXkTWM2OD1{LkW4NlEh|ryP MlPVV2FPT0WU
SN12C M4LRd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULITVExUUN3ME2yMlU5PDh5IN88US=> NHPuWFNUSU6JRWK=
COLO-679 NXPrOJBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Wze2lEPTB;Mj61PFYxPSEQvF2= NUTiVo54W0GQR1XS
U-118-MG Mln0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjyTWM2OD1{LkW4PFczKM7:TR?= NI\1bIxUSU6JRWK=
Ramos-2G6-4C10 Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HMSGlEPTB;Mj62OFgxPyEQvF2= NGfBPYlUSU6JRWK=
HCT-15 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\pWpRKSzVyPUKuOlg4QTJizszN NUH6e4loW0GQR1XS
MDA-MB-157 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTJwN{C3OFch|ryP MkPxV2FPT0WU
K5 Mle3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjveolKSzVyPUKuO|E5PDVizszN M2DYfXNCVkeHUh?=
MKN45 NXix[XJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTRW5JoUUN3ME2yMlc{OzZ4IN88US=> MXPTRW5ITVJ?
DMS-273 NH;YSWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HuU2lEPTB;Mj63OVY{OiEQvF2= M2jFUHNCVkeHUh?=
C8166 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X1ZmlEPTB;Mj63PFUyOyEQvF2= NEHTXWRUSU6JRWK=
Calu-3 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVL1OHg1UUN3ME2yMlc5QTZ7IN88US=> NVPE[IV2W0GQR1XS
SNB75 MkXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTJwOEi1N|Uh|ryP NHHtWYVUSU6JRWK=
BFTC-905 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljFTWM2OD1{LkmwNVkyKM7:TR?= NELOZphUSU6JRWK=
C-4-II M3rsOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTJwOUGzOVMh|ryP MX3TRW5ITVJ?
MS-1 MlfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHP0ZW1KSzVyPUKuPVY4PjlizszN MnPmV2FPT0WU
A375 NV;0T3VzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnW[I9KSzVyPUOuNFgyQDRizszN NYTyfplOW0GQR1XS
KYSE-70 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTNwMEi4PFIh|ryP NHXmN5RUSU6JRWK=
KYSE-510 NVnRUFdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2e5UGlEPTB;Mz6xNFk6PSEQvF2= M{XUTHNCVkeHUh?=
LN-405 M4rTdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLpNlRmUUN3ME2zMlE{PTF6IN88US=> MnnQV2FPT0WU
BOKU MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnz[|RYUUN3ME2zMlE1OjV4IN88US=> MUXTRW5ITVJ?
TE-10 NWHjbnV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml62TWM2OD1|LkG3N|YzKM7:TR?= MoHUV2FPT0WU
MKN1 NVLJOXBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\V[pRGUUN3ME2zMlE5PDh|IN88US=> NEPlcYtUSU6JRWK=
M059J NFXvVlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTNwMkCxO|Mh|ryP NGLOdJFUSU6JRWK=
GOTO MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTNwMkKwN|kh|ryP MVjTRW5ITVJ?
DK-MG NUDSOYkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjESXNFUUN3ME2zMlI2QTd4IN88US=> MYTTRW5ITVJ?
NCI-H727 NIH2eWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTNwMk[1PEDPxE1? M33zSHNCVkeHUh?=
NB12 NXrIbnNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTNwM{OyNlQh|ryP MnvxV2FPT0WU
DOK MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTkTWM2OD1|LkO2NVg3KM7:TR?= M3fUb3NCVkeHUh?=
KYSE-410 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfSW4FzUUN3ME2zMlM3Ojh5IN88US=> NXixT2RlW0GQR1XS
AM-38 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTNwM{iwOVEh|ryP NX;tSop1W0GQR1XS
GR-ST NVX4b3NHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3RXJJnUUN3ME2zMlQ2PzN{IN88US=> NWC3UYJnW0GQR1XS
D-247MG M3Hjc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTNwNEiyOlMh|ryP MlL2V2FPT0WU
TE-8 NV3Kc3FrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLFTWM2OD1|LkS5N|M{KM7:TR?= Ml70V2FPT0WU
LS-411N NXvtblNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUT5SplpUUN3ME2zMlQ6Pjl{IN88US=> M3PDVnNCVkeHUh?=
SK-MES-1 M1nj[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHXPWZLUUN3ME2zMlU3PDN|IN88US=> MYjTRW5ITVJ?
SF295 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrUTXgzUUN3ME2zMlYyPTV{IN88US=> M1u0VHNCVkeHUh?=
SK-MEL-30 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXrUnFKSzVyPUOuOlU6OjFizszN M2LVXnNCVkeHUh?=
LB2241-RCC NHLwR21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnld4JKSzVyPUOuOlYzPiEQvF2= M{XFPHNCVkeHUh?=
PC-14 MkXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVm4ZWp3UUN3ME2zMlY3PDN5IN88US=> NGPTS21USU6JRWK=
EW-7 NUG5OlUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LCNmlEPTB;Mz62O|Y6OyEQvF2= Mn3CV2FPT0WU
NMC-G1 M{GwfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{W4emlEPTB;Mz63NVg{PyEQvF2= M2PwR3NCVkeHUh?=
TE-441-T M3uwNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HaWGlEPTB;Mz63N|AzQCEQvF2= MlzCV2FPT0WU
NCI-H1618 NF3uOlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7md4ExUUN3ME2zMlgyQDd3IN88US=> NFr1XpVUSU6JRWK=
PANC-03-27 NEflbXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XxZWlEPTB;Mz64NVkyPiEQvF2= M3z0ZnNCVkeHUh?=
NCI-H2228 NVf3cIwyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfyR|c5UUN3ME2zMlg{OTJ4IN88US=> NHXETVJUSU6JRWK=
CAPAN-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTNwOEewNFkh|ryP NWnrNoZGW0GQR1XS
KLE NFrIcYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPDUXdRUUN3ME2zMlkxPjdizszN MkT5V2FPT0WU
Becker M1\nOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTNwOUK4OFkh|ryP M1\SeXNCVkeHUh?=
SK-PN-DW M1HQbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPRTpFbUUN3ME20MlA4QTd2IN88US=> MnW4V2FPT0WU
Hs-578-T NH7VSHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTRwMEizNFYh|ryP MmHlV2FPT0WU
RS4-11 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVH2WVJnUUN3ME20MlEyOjV3IN88US=> M{X1VHNCVkeHUh?=
D-502MG NE[4XWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTRwMU[5PVch|ryP NX;FWm53W0GQR1XS
GI-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXkTWM2OD12LkK4Nlk6KM7:TR?= NHG5U|BUSU6JRWK=
NCI-H209 NEfjUHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jiUWlEPTB;ND6zN|c5KM7:TR?= NF\JeohUSU6JRWK=
SK-OV-3 NH;YUJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTRwNEixOFkh|ryP NX;Wc2J{W0GQR1XS
LOUCY NYfmT45FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDmfIVnUUN3ME20MlQ5PDN{IN88US=> MYLTRW5ITVJ?
NCI-H69 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTRwNUG3PVMh|ryP M1nQTnNCVkeHUh?=
SCC-9 M2rXcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTRwNUOxO|Ih|ryP MV7TRW5ITVJ?
NCI-H526 M4XQdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTRwNUmyPVMh|ryP Mo\0V2FPT0WU
NCI-H2170 M4DtZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYGyWWlbUUN3ME20MlY3PzdzIN88US=> NF:1THhUSU6JRWK=
SR NEm0WHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXyyR3FDUUN3ME20MlcxODR6IN88US=> MUDTRW5ITVJ?
CMK Mn\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rsSWlEPTB;ND63NlExOSEQvF2= NGHrT5VUSU6JRWK=
COLO-829 M1nKUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTRwN{ewOFMh|ryP MofsV2FPT0WU
HuO-3N1 M3PHd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PjPWlEPTB;ND64N|I5OSEQvF2= NHqyTlFUSU6JRWK=
5637 NWXVcHJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTRwOUC0PFch|ryP NV3QbVJPW0GQR1XS
A253 M{mwcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NET0d|hKSzVyPUSuPVc4ODhizszN MnXEV2FPT0WU
NB10 MknHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rtSGlEPTB;NT6wO|Q6PyEQvF2= NWLZS2JIW0GQR1XS
SF539 M3vhfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorZTWM2OD13LkC5PVU6KM7:TR?= Mkf6V2FPT0WU
HAL-01 MlLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTVwMUS2OFUh|ryP M4HoW3NCVkeHUh?=
MHH-ES-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37pSmlEPTB;NT6xOlkzPSEQvF2= MX3TRW5ITVJ?
DEL MkDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTVwMke1PFIh|ryP NYqybXVUW0GQR1XS
NCI-H1299 MoHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTCUm8{UUN3ME21MlM2ODB5IN88US=> NELmdFlUSU6JRWK=
ChaGo-K-1 M3\0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33jc2lEPTB;NT6zOVExPyEQvF2= MVvTRW5ITVJ?
HMV-II MlzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3u1dWlEPTB;NT6zPVQ{KM7:TR?= MXvTRW5ITVJ?
NB69 NXHhdmw3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTVwM{m2N|Eh|ryP MXrTRW5ITVJ?
NCI-H1882 MmXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DRV2lEPTB;NT60N|M3PCEQvF2= MYTTRW5ITVJ?
SNU-475 NF[3RXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTVwNEexO|Eh|ryP MVHTRW5ITVJ?
RXF393 NXvXbVQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTVwNEi0PVQh|ryP MkTuV2FPT0WU
CAL-51 M2jhXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXCVYhNUUN3ME21MlYzQDV|IN88US=> NF7TVpNUSU6JRWK=
SW1573 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnxcXp{UUN3ME21MlY{PTN2IN88US=> NVj6eopGW0GQR1XS
GCT NHT2RYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TodmlEPTB;NT63OVkzQSEQvF2= NWTXPHpsW0GQR1XS
COR-L88 M3zNRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITTfpBKSzVyPUWuO|Y5PDZizszN MmrLV2FPT0WU
MDA-MB-134-VI NUDsRlhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYr0N5lFUUN3ME21Mlg4PTN4IN88US=> MWDTRW5ITVJ?
NB5 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXLfpZKSzVyPUWuPVI1PCEQvF2= MmD6V2FPT0WU
GMS-10 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mki4TWM2OD13Lkm2PFYyKM7:TR?= M1XhOHNCVkeHUh?=
CHP-212 M2Xm[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH1TWM2OD14LkS4NlY4KM7:TR?= NWjIbIlsW0GQR1XS
TE-11 NYHYV3hST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTzcpVjUUN3ME22MlU2OTh{IN88US=> NGe1U4tUSU6JRWK=
SW962 NWLhRoROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXiTWM2OD14Lk[1O|c1KM7:TR?= NHPzfXpUSU6JRWK=
MZ2-MEL Mke5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\MTWM2OD14LkiyNFEyKM7:TR?= M3HYR3NCVkeHUh?=
C-33-A Mm\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nT[2lEPTB;Nj65NVY5QCEQvF2= M4LJRnNCVkeHUh?=
IGR-1 M2fx[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXWTWM2OD14Lkm3PFI3KM7:TR?= M1GxfHNCVkeHUh?=
MOLT-4 M1HJ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTdwMUW0NFYh|ryP NXLOU4FmW0GQR1XS
NCI-H1650 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlX2TWM2OD15LkK3NFQ3KM7:TR?= MlPrV2FPT0WU
AsPC-1 M{PyfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrWZpp5UUN3ME23MlI5PjB3IN88US=> NFLjdFFUSU6JRWK=
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LU-165 NGDVUVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3G4RmlEPTB;MkKuOVU1KM7:TR?= M3n4d3NCVkeHUh?=
COLO-792 NGXNZZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\RTWM2OD1{Mj63NVEyKM7:TR?= NInYS3BUSU6JRWK=
CAL-62 NEn4TFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTJ{Lke1NVch|ryP M4HPZ3NCVkeHUh?=
HCE-T MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2njVGlEPTB;MkKuPFYxPiEQvF2= NXe3XotxW0GQR1XS
BB65-RCC MkXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTWTWM2OD1{Mz6wN|Q1KM7:TR?= MVjTRW5ITVJ?
SiHa NUfCUoh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkezTWM2OD1{Mz6zPVY5KM7:TR?= NXTXPVZoW0GQR1XS
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U251 M1yzSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HTdWlEPTB;MkSuNFY3QCEQvF2= NIXkbZBUSU6JRWK=
LoVo Ml2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHrZWRKSzVyPUK0MlkzQDJizszN MmjyV2FPT0WU
GCIY MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJ3LkK4O|ch|ryP NXPOUGhLW0GQR1XS
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PA-1 NF7Y[2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTldGRKSzVyPUK1MlY5OzNizszN NXjEdm15W0GQR1XS
OE33 Mn\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTJ3Lk[4OVMh|ryP Mn36V2FPT0WU
HT-29 MoXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXTdYJGUUN3ME2yOU44QDd7IN88US=> MmW0V2FPT0WU
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NCI-H1522 M1XIbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PVRmlEPTB;MkWuPVkyOSEQvF2= MlKzV2FPT0WU
LB373-MEL-D MkCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{j5bmlEPTB;Mk[uNVcxQCEQvF2= MXHTRW5ITVJ?
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GAK NYLkfZVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHKTWM2OD1{Nz60NlI2KM7:TR?= NGjTcXZUSU6JRWK=
MDA-MB-175-VII M1LxWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[5TWM2OD1{Nz61NFU{KM7:TR?= MnW2V2FPT0WU
JVM-2 NYPKWHJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTJ5Lk[2NlIh|ryP NWf4NnlMW0GQR1XS
UACC-257 M3vvdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWS0eJBLUUN3ME2yO{43QDd6IN88US=> M2KwUHNCVkeHUh?=
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HT-3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHjUZg6UUN3ME2yPE4zOTZ4IN88US=> MWTTRW5ITVJ?
RL M{jBfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTJ6LkW5NVEh|ryP NHLuNJdUSU6JRWK=
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HT55 NGHDbFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfaflllUUN3ME2yPU4xPTZ3IN88US=> NVz5cI8zW0GQR1XS
BT-20 M3TKWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHhbJpPUUN3ME2yPU4xPTh4IN88US=> MnzhV2FPT0WU
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GT3TKB M1fme2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTJ7Lk[4O|ch|ryP M{f2O3NCVkeHUh?=
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PFSK-1 NWSz[2FOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3RTWM2OD1|MT6yOlU6KM7:TR?= M4PqUnNCVkeHUh?=
JEG-3 NHj6VGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[zTWM2OD1|MT6zOVYyKM7:TR?= NFvLTGtUSU6JRWK=
RD MlHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTMRY5tUUN3ME2zNU42OTF3IN88US=> NVvkd3o6W0GQR1XS
NCI-H64 NED5SIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{S1TmlEPTB;M{KuOFE4QSEQvF2= NHTq[4RUSU6JRWK=
DMS-114 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7yTWM2OD1|Mj60NVgzKM7:TR?= Ml7VV2FPT0WU
NCI-H661 MnjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXVRmdKSzVyPUOyMlY2ODFizszN MnjoV2FPT0WU
CAL-148 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV74WVZsUUN3ME2zNk43PjZ3IN88US=> NFfwbFFUSU6JRWK=
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Ca9-22 MlfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPPcINKSzVyPUOzMlQ3ODFizszN MYPTRW5ITVJ?
LP-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTN2LkC5JO69VQ>? MYjTRW5ITVJ?
AU565 MkS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvJTWM2OD1|ND61NFY6KM7:TR?= MkHlV2FPT0WU
MDA-MB-453 Mk\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvBTWM2OD1|NT6xOFI3KM7:TR?= NV7XNWN6W0GQR1XS
SNU-C1 NV3CN4NvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjRV4lKSzVyPUO1MlE4OSEQvF2= MoW1V2FPT0WU
SW13 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvkTWM2OD1|NT60NFc3KM7:TR?= NHXzT5FUSU6JRWK=
NCI-H2122 NWTl[Y8xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLvTWM2OD1|NT61OVk5KM7:TR?= NWi3NmZ2W0GQR1XS
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ATN-1 NV;VO3NwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHwWVBOUUN3ME2zOk45PTF4IN88US=> NHTUWpVUSU6JRWK=
HCC2998 M1XRN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1H4fWlEPTB;M{[uPFU4OSEQvF2= NH\qXXpUSU6JRWK=
UM-UC-3 M1r0Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;LfmlEPTB;M{[uPFY4PSEQvF2= M1O3bXNCVkeHUh?=
DV-90 M4j3PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnLTWM2OD1|Nj65NFY4KM7:TR?= MmDGV2FPT0WU
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UMC-11 NUjB[Jh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzwTWM2OD1|Nz6yOVA{KM7:TR?= NVT4Z4NJW0GQR1XS
THP-1 NHmwWWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXib|BKSzVyPUO3MlI5PjhizszN NGHLcnRUSU6JRWK=
OCUB-M M13Jbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTN5LkK4PVEh|ryP MY\TRW5ITVJ?
NCI-H1693 NIn3UppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\5fIs4UUN3ME2zO{4{OjN|IN88US=> MoXsV2FPT0WU
NCI-H345 NUnMdFFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzuTWM2OD1|Nz6zOlI1KM7:TR?= NVuybYhqW0GQR1XS
COLO-800 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;LR3pKSzVyPUO3MlU3PyEQvF2= NECyfGJUSU6JRWK=
COLO-320-HSR NGXPUVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTN6LkO0PVIh|ryP NU\RNoNYW0GQR1XS
NCI-H596 M4n0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrlTWM2OD1|OD60OFg6KM7:TR?= NH;PcYtUSU6JRWK=
NCI-H187 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTN6LkezOFQh|ryP M3fT[HNCVkeHUh?=
ECC4 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\oXW9PUUN3ME2zPU4xQDF2IN88US=> MkTsV2FPT0WU
KP-4 M4m3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH[0fnRKSzVyPUO5MlEzOzVizszN Mlq0V2FPT0WU
NCI-H2227 NGfSeGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\0[VM3UUN3ME2zPU4{QTR7IN88US=> NVfwPVR7W0GQR1XS
22RV1 NVi0elU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jHZWlEPTB;M{muPFM6QCEQvF2= NXqySGxyW0GQR1XS
SAS MkPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;mbI5KSzVyPUSwMlA6PiEQvF2= NUnRcohJW0GQR1XS
PANC-10-05 NXLPN3FlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE[1NJJKSzVyPUSwMlE5OjhizszN NYDmS|VzW0GQR1XS
MDA-MB-468 NYfTdG1NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTRyLkWzOFYh|ryP NXT6Tm5XW0GQR1XS
RPMI-7951 NID0U5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFriPZpKSzVyPUSxMlIxPzVizszN M{j5WnNCVkeHUh?=
BB49-HNC Ml3IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDqR4hKSzVyPUSxMlIyPzlizszN NGqxT5pUSU6JRWK=
23132-87 NUjYTJU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTRzLkK3N|Ih|ryP NVvmcVBSW0GQR1XS
HCC1569 NGTLeZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLEflVrUUN3ME20NU4zQDh3IN88US=> NXXWRmx[W0GQR1XS
CP66-MEL MkDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTR{LkG4PFYh|ryP MkTaV2FPT0WU
K-562 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILrZ|lKSzVyPUSyMlI5PTRizszN NYfiWohEW0GQR1XS
OCI-AML2 M4rkb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PGbmlEPTB;NEKuPFk4PCEQvF2= NInPTmtUSU6JRWK=
SW756 NGDXVYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoizTWM2OD12Mz6wN|g5KM7:TR?= MXLTRW5ITVJ?
M14 Mn36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fmWWlEPTB;NEOuN|E5QSEQvF2= MXXTRW5ITVJ?
NCI-H1623 NGrXSWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3znRWlEPTB;NEOuOFY1KM7:TR?= MV3TRW5ITVJ?
KNS-81-FD MnzTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnr0TWM2OD12Mz63OlIh|ryP MkmyV2FPT0WU
TGBC1TKB MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLSTWM2OD12Mz65NFk6KM7:TR?= M3exZXNCVkeHUh?=
RERF-LC-MS NX7DcJhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHDXXlxUUN3ME20N{46OjhzIN88US=> MUPTRW5ITVJ?
PC-3 M1W5VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zU[WlEPTB;NESuOFM1PyEQvF2= NHXPNItUSU6JRWK=
HuP-T4 M4G1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\OO21MUUN3ME20OE41PDd2IN88US=> MmjJV2FPT0WU
NCI-H510A M2PNXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXGTWM2OD12ND63NFgh|ryP M1Ppe3NCVkeHUh?=
LB2518-MEL MkC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\iPINKSzVyPUS0Mlc6OzdizszN MlzDV2FPT0WU
TE-5 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIG3Z21KSzVyPUS1Mlk2QDFizszN M3zQV3NCVkeHUh?=
EW-24 NXizZmh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTR4LkG3NlMh|ryP NXTqSZJqW0GQR1XS
LB647-SCLC MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnDelhpUUN3ME20Ok4zOTV3IN88US=> M4W3WHNCVkeHUh?=
NCI-H524 NXXlfGE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXG2eIFpUUN3ME20Ok44OTh3IN88US=> NIXDb2FUSU6JRWK=
EW-11 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPjTWM2OD12Nj65N|c{KM7:TR?= Mm\FV2FPT0WU
KALS-1 M3v6Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;VO2lEPTB;NEeuNlA3PiEQvF2= MYnTRW5ITVJ?
BT-474 M{Lo[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTR5LkSyNVYh|ryP NGftNI5USU6JRWK=
SK-N-AS MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PqUGlEPTB;NEeuPFg5KM7:TR?= NFjMbWhUSU6JRWK=
HCC2157 M{HjUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGryToZKSzVyPUS4MlA4PiEQvF2= NUP0flYzW0GQR1XS
HCC1954 NVfjSlRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVW3e|V{UUN3ME20PE4yPzB2IN88US=> NXf4PGZyW0GQR1XS
FADU M4XWZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTR6LkOwN|Eh|ryP MkW4V2FPT0WU
S-117 M4f6OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTCTWM2OD12OD6zPFE2KM7:TR?= M2fTTXNCVkeHUh?=
LS-1034 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Da[WlEPTB;NEiuO|A3PyEQvF2= M{\aXHNCVkeHUh?=
CAMA-1 NIe5foVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLyTWM2OD12OT61OVQ{KM7:TR?= Mk\vV2FPT0WU
LU-134-A NGDvT5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGiwc3BKSzVyPUS5MlgxQDVizszN NH;SS5BUSU6JRWK=
NCI-H1838 MmeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\2TWM2OD12OT64NFg4KM7:TR?= MlrhV2FPT0WU

... Click to View More Cell Line Experimental Data
体内研究 Ponatinib抑制取自FLT3-ITD阳性AML病人的原代白血病细胞，而不抑制表达阴性FLT3的AML病人的白血病细胞。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验：[1]
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激酶实验:

通过同质时间分辨荧光共振能量转移法(TR-FRET)，使用纯化的人类野生型ABL激酶，T315I突变型ABL激酶，及生物素化的磷酸激酶底物肽: 生物素-EKKMAAEAIYAAPFAK-NH2，测定野生型ABL和T315I突变型ABL活性的抑制激酶反应在全LANCE激酶buffer (LKB)中进行，LKB包括20 mM NaHEPES（pH 为7.4）, 0.1 mg ⁄ mL BSA, 1 mM ATP, 10 mM MgCl2, 及0.41 mM DTT，在提前用1% BSA（溶于PBS）包被的96孔板上4oC下过夜。用于激酶反应，Ponatinib稀释物和野生型ABL, T315I突变型ABL (40 pM), 及底物肽(50 nM), 在室温下温育1小时（T315I突变型ABL）或2小时（野生型ABL）。加入15 nM 抑制剂, 6 nM 铕标记的磷酸酪氨酸抗体（磷酸化位点在第66为酪氨酸上），及60 nM 别藻蓝素标记的链酶亲和素，终止反应。实验板在室温下黑暗温育20分钟，使用Wallac Victor2V读数器读取615和665nm处的荧光值。在孔中数据平均值中插入抑制剂的3倍连续稀释液，再读取665nm处荧光值，计算IC50值。
细胞实验：[1]
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  • Cell lines: Ba ⁄ F3细胞
  • Concentrations: 0-625 nM, 和0-10 µM
  • Incubation Time: 72小时
  • Method: Ba/F3细胞系按每孔4×103个细胞分布在96孔板上(4×103)，和梯度浓度Ponatinib温育72小时。Ponatinib浓度范围为: 0-625 nM 作用于表达BCR-ABL细胞，0-10 µM 用于测定BCR-ABL阴性细胞。使用MTS实验测定细胞增殖，取三次平行实验平均值测定IC50值。
    (Only for Reference)
动物实验：[3]
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  • Animal Models: 皮下植入MV4-11细胞移植瘤(1×107，50%基质胶中) 的雌性CB.17 SCID鼠
  • Formulation: 25 mmol/L柠檬酸盐缓冲液(pH 为2.75)
  • Dosages: 每天处理一次，持续4周
  • Administration: 口服饲喂处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)：
1% CMC Na 		30mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 532.56
化学式

C29H27F3N6O
CAS号 943319-70-8
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量：

总分子量：g/mol

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03709017 Recruiting Chronic Myeloid Leukemia|Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia Korea Otsuka Pharmaceutical Co. Ltd. October 2018 --
NCT03690115 Not yet recruiting Leukemia Myeloid Acute Versailles Hospital October 2018 Phase 2
NCT03704688 Recruiting Non Small Cell Lung Cancer|KRAS Gene Mutation Memorial Sloan Kettering Cancer Center October 9 2018 Phase 1|Phase 2
NCT03589326 Recruiting Lymphoblastic Leukemia Acute Adult|Acute Lymphoid Leukemia|Leukemia Acute Lymphoblastic|Leukemia Lymphoblastic|Ph1 Chromosome|Leukemia Lymphoblastic Acute Philadelphia-Positive Millennium Pharmaceuticals Inc.|Takeda August 10 2018 Phase 3
NCT03576547 Recruiting Blast Phase Chronic Myelogenous Leukemia BCR-ABL1 Positive|Philadelphia Chromosome Positive|Recurrent Acute Lymphoblastic Leukemia|Recurrent Chronic Myelogenous Leukemia BCR-ABL1 Positive|Refractory Acute Lymphoblastic Leukemia|Refractory Chronic Myelogenous Leukemia BCR-ABL1 Positive|t(9;22) M.D. Anderson Cancer Center|National Cancer Institute (NCI) June 26 2018 Phase 1|Phase 2
NCT03147612 Recruiting Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia With BCR-ABL1|Philadelphia Chromosome Positive|Recurrent Acute Lymphoblastic Leukemia|Refractory Acute Lymphoblastic Leukemia M.D. Anderson Cancer Center|National Cancer Institute (NCI) February 8 2018 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1：

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答：

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

Selleck产品目录册

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

  • 选择性强的Bcr-Abl抑制剂

    Nilotinib (AMN-107) : Bcr-Abl-selective, IC50<30 nM.

  • 活性最高的Bcr-Abl抑制剂

    GZD824 : Bcr-Abl(WT), IC50=0.34 nM; Bcr-Abl(T315I), IC50=0.68 nM.

  • FDA批准的Bcr-Abl抑制剂

    Dasatinib : Approved by FDA for CML and Ph+ ALL.

  • 最新的Bcr-Abl抑制剂

    GZD824 : Orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

相关Bcr-Abl产品

  • PX-478 2HCl New

    PX-478 2HCl是一种具有口服活性的选择性hypoxia-inducible factor-1α (HIF-1α)抑制剂。Phase 1。

  • Defactinib (VS-6063, PF-04554878) New

    Defactinib (VS-6063, PF-04554878)是一种选择性，且口服有效的FAK抑制剂。Phase 2。

  • SU6656 New

    SU 6656 是一种选择性 Src 家族激酶抑制剂，对Src，Yes，Lyn，和 Fyn 的 IC50 分别为 280 nM，20 nM，130 nM，和 170 nM。

  • Imatinib Mesylate (STI571)

    Imatinib Mesylate (STI571)是一种口服生物有效的Imatinib甲磺酸盐，是一种多靶点抑制剂，作用于v-Abl，c-Kit和PDGFR，在无细胞和细胞试验中，IC50分别为0.6 μM，0.1 μM 和0.1 μM。

  • Nilotinib (AMN-107)

    Nilotinib (AMN-107)是一种特异性BCR-ABL抑制剂，在小鼠骨髓祖细胞中IC50低于30 nM。

    Features:Nilotinib 是Abl选择性抑制剂，与BCR-ABL的ATP结合位点相互作用。

  • Bafetinib (INNO-406)

    Bafetinib (INNO-406)是一种有效的，选择性的，双重Bcr-Abl/Lyn双重抑制剂，无细胞试验中IC50为5.8 nM/19 nM，对T315I突变型的磷酸化没有抑制作用，对PDGFR和c-Kit的作用效果较弱。Phase 2。

    Features:Bafetinib是有效的双重Bcr-Abl/Lyn酪氨酸激酶选择性抑制剂。

  • Degrasyn (WP1130)

    Degrasyn (WP1130)是一种选择性deubiquitinase (DUB: USP5，UCH-L1，USP9x，USP14，和 UCH37)抑制剂，对Bcr/Abl也有抑制作用，也是一种JAK2传感器(不影响20S蛋白酶体)和转录激活剂(STAT)。

    Features:WP1130 has an advantage over imatinib mesylate in that its activity is not inhibited by a variety of Abl kinase mutations, including T315I.

  • Rebastinib (DCC-2036)

    Rebastinib (DCC-2036)是一种Bcr-Abl抑制剂，作用于Abl1(WT)和Abl1(T315I)，IC50分别为0.8 nM和4 nM，也抑制SRC， LYN， FGR， HCK， KDR， FLT3，和Tie-2，对c-Kit具有低的抑制活性。Phase 1。

  • GZD824 Dimesylate(HQP1351)

    GZD824 Dimesylate是新型口服有效的Bcr-Abl抑制剂，作用于Bcr-Abl(WT)和Bcr-Abl(T315I)，IC50分别为0.34 nM和0.68 nM。

  • GNF-2

    GNF-2是一种高选择性，非ATP竞争性的Bcr-Abl抑制剂，对Flt3-ITD， Tel-PDGFR， TPR-MET和Tel-JAK1转化的肿瘤细胞没有作用活性。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID