Ponatinib (AP24534)

For research use only. Not for use in humans.

目录号：S1490 中文名称：帕纳替尼

CAS No. 943319-70-8

Ponatinib (AP24534)是一种新型有效的多靶点抑制剂，在无细胞试验中作用于Abl，PDGFRα，VEGFR2，FGFR1和Src，IC50分别为0.37 nM，1.1 nM，1.5 nM，2.2 nM和5.4 nM。Ponatinib (AP24534)可抑制自噬。

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10mM (1mL in DMSO)	RMB 819.31	现货
10mg	RMB 903.01	现货
50mg	RMB 3034.48	现货
200mg	RMB 7959.08	现货
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客户使用Selleck生产的Ponatinib (AP24534)发表文献146篇：

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产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

产品描述

靶点

Abl ^[1] (Cell-free assay)	PDGFRα ^[1] (Cell-free assay)	VEGFR2 ^[1] (Cell-free assay)	FGFR1 ^[1] (Cell-free assay)	c-Src ^[1] (Cell-free assay)	点击更多
0.37 nM	1.1 nM	1.5 nM	2.2 nM	5.4 nM	点击更多

体外研究

Ponatinib是有效的可用于口服的多靶点激酶抑制剂，作用于野生型细胞,及T315I 突变细胞IC50分别为1.2和8.8nM。^[1] Ponatinib抑制Ba/F3衍生细胞系的增殖。^[2] Ponatinib作用于表达野生型或T315I突变型BCR-ABL的CML细胞系，有效抑制BCR-ABL调节的信号。Ponatinib阻断在细胞瘤筛选时产生抗性突变。^[3] Ponatinib也抑制VEGFR和FGFR家族激酶，在体外抑制FLT3, KIT, FGFR1,和PDGFRa激酶活性时IC50分别为13, 13, 2, 和1 nM.^[4]Ponatinib抑制全部4种RTKs磷酸化，存在剂量依赖性，IC50值为0.3到20 nM。然而，Ponatinib抑制表达野生型FLT3的RS4;11细胞时IC50>100 nM。

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
EoL-1-cell	Mn3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmjvTWM2OD1yLkCwNFAxODB\|NUmg{txO	MoPZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
MV-4-11	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWX3ZXh3UUN3ME2wMlAxODB7NU[g{txO	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
MEG-01	NF;XSVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4HZVGlEPTB;MD6wNFAyOjhizszN	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
LAMA-84	MlfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3XhVWlEPTB;MD6wNFAyPjVizszN	NUDMUZlLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
CGTH-W-1	NX3VeXp{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFPVOWlKSzVyPUCuNFAyPjlizszN	M{fid\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
KASUMI-1	NX3lZ\|Y1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXrFUGRRUUN3ME2wMlAxOjF5IN88US=>	M33sbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
BE-13	M{nPe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml\BTWM2OD1yLkCwNlU6KM7:TR?=	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
CTV-1	Ml3BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{HnS2lEPTB;MD6wNFUzOSEQvF2=	NHHl[lY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
NKM-1	M4PKUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWr0T2dvUUN3ME2wMlAxPjV3IN88US=>	NXvqfXlQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
MONO-MAC-6	NELDO4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEPyPXJKSzVyPUCuNFA5OzdizszN	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
A204	M1TlZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4\UdmlEPTB;MD6wNVIyQCEQvF2=	M{Tnb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
GDM-1	MknvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MX\JR\|UxRTBwMEG4N\|Mh\|ryP	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
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HEC-1	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4W4e2lEPTB;MT6zN\|c2PSEQvF2=	M3vFSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
ME-180	MlGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVm3ZnYxUUN3ME2xMlM4QTl\|IN88US=>	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
MMAC-SF	MoLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mk\4TWM2OD1zLkO5OVk2KM7:TR?=	NEnxTYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
IA-LM	M2LZSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFvoVmhKSzVyPUGuOFA6OTRizszN	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
MN-60	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUHJR\|UxRTFwNEOxNVQh\|ryP	M1rHO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
SIMA	MlnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mlr2TWM2OD1zLkS4Olg4KM7:TR?=	MlHpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
NCI-H1770	M4PJTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHjDXnhKSzVyPUGuOVIxPTRizszN	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
ONS-76	NHK1b3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MknFTWM2OD1zLkWyN\|EyKM7:TR?=	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
LB771-HNC	NVnaOlVmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFroe3ZKSzVyPUGuOVM6ODZizszN	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
SW48	MkDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXHJR\|UxRTFwNUSyOFMh\|ryP	NWLFPG5bRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
KYSE-140	M2fBOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3nRfmlEPTB;MT61OVc1OSEQvF2=	M1jOWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
SW626	NHHuUW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWW0[XhuUUN3ME2xMlU5OTZizszN	NY\XVWpkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
MC-CAR	MlPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mon0TWM2OD1zLkW4OlY{KM7:TR?=	M{DlNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
D-336MG	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXf3XYtEUUN3ME2xMlYzQTRizszN	NFHDepg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
SK-MEL-3	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYPJR\|UxRTFwNkO5NFIh\|ryP	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
MHH-PREB-1	NVfrbmVmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1ryWGlEPTB;MT62OFQ4OyEQvF2=	M1LPNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
Calu-1	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF[z[\|BKSzVyPUGuOlU{QDZizszN	MnzwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
HCC1806	NGnJWW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4HrdWlEPTB;MT62OlYyOSEQvF2=	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
A101D	NUnJS4NPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1LTTmlEPTB;MT62Olc5OSEQvF2=	NIewW4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
A704	M1;ncWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2D4emlEPTB;MT62PFMyOSEQvF2=	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
LB831-BLC	MmrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkD6TWM2OD1zLk[5PFU1KM7:TR?=	NYHINHg{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
RL95-2	M1fkT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{jOOmlEPTB;MT63NVQ3OyEQvF2=	NH23TJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
RPMI-2650	NEL2fJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MU\JR\|UxRTFwN{K3NVkh\|ryP	NV;INXByRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
NH-12	MlTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEnacZpKSzVyPUGuO\|M1OjdizszN	NXrBTGxIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
AGS	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoXjTWM2OD1zLke2N\|U5KM7:TR?=	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
NEC8	MkPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1jESGlEPTB;MT63PFk6PSEQvF2=	Ml3oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
NCI-H2009	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2Hye2lEPTB;MT63PVczOSEQvF2=	M{CyelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
A498	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVvJR\|UxRTFwOEGyPFIh\|ryP	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
NCI-H810	M3vXXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVPJR\|UxRTFwOEG2NFYh\|ryP	MlfPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
SK-NEP-1	MkjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXXJR\|UxRTFwOEO3Olch\|ryP	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
D-542MG	NIrUOJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF;2eWNKSzVyPUGuPFU5PTFizszN	M2LpWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
KNS-42	M{j6dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUTMUlFbUUN3ME2xMlg3OjZ4IN88US=>	M{XKUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
NCI-H2452	NEjDd45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF;2d\|FKSzVyPUGuPFkxPzRizszN	M2K4XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
SK-MEL-2	MmrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4foT2lEPTB;MT65NFI4OSEQvF2=	Mn\6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
OVCAR-5	MlTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NITtboxKSzVyPUGuPVA3PzVizszN	M2LvOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
SNG-M	M2TZXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3zpSWlEPTB;MT65OVg2QCEQvF2=	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
A673	NX:4NFBRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVLCU2VRUUN3ME2xMlk4PTF4IN88US=>	NVvyRW8xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
L-428	NGLtR\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEnVTYFKSzVyPUGuPVkyPzlizszN	NFXWZlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
KM-H2	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEjvUJBKSzVyPUKuNFExQSEQvF2=	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
MC-IXC	MmfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWHQTppSUUN3ME2yMlAzOjd\|IN88US=>	MorCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
COLO-678	M4f5dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXLJR\|UxRTJwMESyNFch\|ryP	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
MEL-JUSO	M3Kybmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NITvOW1KSzVyPUKuNFc5PTFizszN	NFzvcHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
HCC38	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn70TWM2OD1{LkC4OFM{KM7:TR?=	Mmm5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
UACC-62	M2DqS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVnJR\|UxRTJwMEi4OVUh\|ryP	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
OAW-42	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{TjdWlEPTB;Mj6wPVcyOSEQvF2=	M3XTblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
LB996-RCC	NYHEXGhnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXHBb45tUUN3ME2yMlE{QDF5IN88US=>	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
COR-L105	NHn2bplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1\PT2lEPTB;Mj6xOlM4OyEQvF2=	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
RCC10RGB	M1;Sc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHLKWZVKSzVyPUKuNVg2PzZizszN	Ml;iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
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SK-MES-1	NEnJR3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF6xd4dKSzVyPUOuOVY1OzNizszN	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
SF295	MnHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVXJR\|UxRTNwNkG1OVIh\|ryP	MoLSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
SK-MEL-30	NITOcXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUTJR\|UxRTNwNkW5NlEh\|ryP	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
LB2241-RCC	NGnqbXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2jmPGlEPTB;Mz62OlI3KM7:TR?=	M2fkbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
PC-14	M4q1ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkP4TWM2OD1\|Lk[2OFM4KM7:TR?=	M3:ye\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
EW-7	MnvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3LVOmlEPTB;Mz62O\|Y6OyEQvF2=	NIHwcoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
NMC-G1	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVnFSlI3UUN3ME2zMlcyQDN5IN88US=>	M2fPSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
TE-441-T	NYDN[JZVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWf4[IhDUUN3ME2zMlc{ODJ6IN88US=>	M4LINFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
NCI-H1618	M3zTbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWTJR\|UxRTNwOEG4O\|Uh\|ryP	M4fsdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
PANC-03-27	MmrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1TET2lEPTB;Mz64NVkyPiEQvF2=	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
NCI-H2228	NX[2cIpNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXnJR\|UxRTNwOEOxNlYh\|ryP	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
CAPAN-1	NHfqT5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUDJR\|UxRTNwOEewNFkh\|ryP	MlXXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
KLE	NEnYZYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUfJV3F1UUN3ME2zMlkxPjdizszN	NH63T3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
Becker	M2S2RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mmm2TWM2OD1\|LkmyPFQ6KM7:TR?=	M1HsSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
SK-PN-DW	NYLidHVPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUPsUmRwUUN3ME20MlA4QTd2IN88US=>	Ml;EQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
Hs-578-T	M1TXfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEfRb3ZKSzVyPUSuNFg{ODZizszN	NHjicmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
RS4-11	NIHJRmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVvjcYM4UUN3ME20MlEyOjV3IN88US=>	NVPvNGkyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
D-502MG	NITjfFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1TJemlEPTB;ND6xOlk6PyEQvF2=	M33HSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
GI-1	M3nMVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWjUbJh5UUN3ME20MlI5Ojl7IN88US=>	NVjTOlhWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
NCI-H209	NV7sVWxvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MULJR\|UxRTRwM{O3PEDPxE1?	NVHHV456RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
SK-OV-3	M1HFeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{LLSGlEPTB;ND60PFE1QSEQvF2=	NXu4VZc5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
LOUCY	M33BWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MX\JR\|UxRTRwNEi0N\|Ih\|ryP	NFLrXJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
NCI-H69	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYnJR\|UxRTRwNUG3PVMh\|ryP	NYHsdFlSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
SCC-9	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mon4TWM2OD12LkWzNVczKM7:TR?=	NFG0b4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
NCI-H526	NVvJc3NuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn;1TWM2OD12LkW5Nlk{KM7:TR?=	M3;kVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
NCI-H2170	M{LnPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIOyPWFKSzVyPUSuOlY4PzFizszN	M2LTV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
SR	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWPD[odxUUN3ME20MlcxODR6IN88US=>	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
CMK	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlTLTWM2OD12LkeyNVAyKM7:TR?=	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
COLO-829	M1XGfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX;hZ3ZNUUN3ME20Mlc4ODR\|IN88US=>	MmfNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
HuO-3N1	NFHRS4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn3nTWM2OD12LkizNlgyKM7:TR?=	MmrLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
5637	NFPibm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlH6TWM2OD12LkmwOFg4KM7:TR?=	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
A253	MnLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWL1W4VUUUN3ME20Mlk4PzB6IN88US=>	M3KyblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
NB10	M3jwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYDJR\|UxRTVwMEe0PVch\|ryP	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
SF539	MkXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX\ZdGl6UUN3ME21MlA6QTV7IN88US=>	MoroQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
HAL-01	NULqfmk{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MY\JR\|UxRTVwMUS2OFUh\|ryP	MnXjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
MHH-ES-1	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYXJR\|UxRTVwMU[5NlUh\|ryP	NGrjc\|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
DEL	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHLjVVZKSzVyPUWuNlc2QDJizszN	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
NCI-H1299	Moj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1nERWlEPTB;NT6zOVAxPyEQvF2=	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
ChaGo-K-1	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MY\JR\|UxRTVwM{WxNFch\|ryP	Mk\5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
HMV-II	M2jCOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3LLfGlEPTB;NT6zPVQ{KM7:TR?=	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
NB69	NEfPS4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4Xp[mlEPTB;NT6zPVY{OSEQvF2=	NXH4SYhsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
NCI-H1882	Ml7iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHLXRnBKSzVyPUWuOFM{PjRizszN	NVfqUolqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
SNU-475	NWfDcGhOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVjFcI9NUUN3ME21MlQ4OTdzIN88US=>	M1;EO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
RXF393	MmnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlTmTWM2OD13LkS4OFk1KM7:TR?=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
CAL-51	NFruSnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2HaOmlEPTB;NT62Nlg2OyEQvF2=	M{H6UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
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MC116	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYPJR\|UxRTF3LkG1PVkh\|ryP	MlLsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
IGROV-1	NYDwdZhIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkfMTWM2OD1zNT6yN\|E4KM7:TR?=	NI\CUFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
NCI-H1648	NEXrbVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnvCTWM2OD1zNT61N\|A2KM7:TR?=	NGKweW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
ABC-1	NWPk[YdJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEHMfo1KSzVyPUG1MlgxOzNizszN	NWHFcYprRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
EW-18	M{nEcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml;2TWM2OD1zNT65PVc6KM7:TR?=	Ml3FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
BC-3	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUnJR\|UxRTF4LkC1OlIh\|ryP	MnPlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
NCI-H1437	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFLnWYtKSzVyPUG2MlA3PjdizszN	Mnm1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
SCC-15	MnjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXf5V41DUUN3ME2xOk4zQDJ3IN88US=>	NXjvTJdIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
TT	NFfKNlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXm5T2pKUUN3ME2xOk42QDh6IN88US=>	NILZXYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
KINGS-1	Mm[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn76TWM2OD1zNj64Nlc{KM7:TR?=	NXWxPHRSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
C32	NIjGVWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUTIZY9vUUN3ME2xOk46PzF5IN88US=>	MnO2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
SBC-5	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4e3UmlEPTB;MUeuNVQ4QSEQvF2=	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
NB1	Ml3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkCyTWM2OD1zNz6zNVg5KM7:TR?=	NYroV4FiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
EB-3	NWHBbIN5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVvJR\|UxRTF5LkW3OkDPxE1?	M4\QRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
NCI-H748	NUfPcIFwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX\ueWQxUUN3ME2xO{44ODN3IN88US=>	M3zGUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
IST-SL1	NIi3XZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmrPTWM2OD1zNz63OVI3KM7:TR?=	NWnGd3c6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
WM-115	NGH3WIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWfJR\|UxRTF5LkiwPFUh\|ryP	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
NCI-H226	MofrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEH1SmhKSzVyPUG3Mlk2PDZizszN	MnjqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
CAL-33	NUDnTZpmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVnJR\|UxRTF6LkK3PFEh\|ryP	NYHlOJR1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
SCC-4	MlTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MULJR\|UxRTF6LkOyNlkh\|ryP	MlvvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
RMG-I	MlntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGXnUVBKSzVyPUG4MlY6PDdizszN	NYrGToRCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
KOSC-2	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmrvTWM2OD1zOD63O\|Q3KM7:TR?=	Ml7qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
A2058	MnHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEHYOnZKSzVyPUG4MlgzPTVizszN	NGq0WZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
HCC70	M2jP[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4C4eWlEPTB;MUmuN\|g6PCEQvF2=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
C2BBe1	NULQ[pFGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF7pd49KSzVyPUG5MlQyPDhizszN	NWfWb5B4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
NCI-H650	NFHxZ5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGnVN3JKSzVyPUG5MlU5QTlizszN	NHr1NnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
CAL-72	Mlr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHi4c5JKSzVyPUG5MlY4OzdizszN	NHTy[3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
L-363	M2CxZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnvQTWM2OD1{MD6wNlEzKM7:TR?=	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
SNU-423	MkH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV\GcZVmUUN3ME2yNE4yODR\|IN88US=>	M3HKSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
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SW1463	MlrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXztOpQ1UUN3ME2yNE41PTJ3IN88US=>	NFPxNGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
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DMS-79	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M361dGlEPTB;MkCuPFQ6KM7:TR?=	NFO1W5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
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CHP-126	NYLwfnJpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3LhWmlEPTB;MkGuOFQ3OiEQvF2=	NWHNRnd[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
SW837	NISxe2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{P2S2lEPTB;MkGuOFk{QSEQvF2=	NHPmV3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
SHP-77	NWnnWmQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlLNTWM2OD1{MT62NVIzKM7:TR?=	NXq4WFI3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
DB	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWP6TmZ5UUN3ME2yNU43OTR{IN88US=>	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
ES5	NFvLUFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXnuTW9uUUN3ME2yNU43QDZ2IN88US=>	MkLtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
COR-L23	NFL6Wo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{XrTGlEPTB;MkGuPFA2OSEQvF2=	NFPndpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
KU-19-19	NGG0TJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIS4R2dKSzVyPUKxMlg6QDJizszN	M4TVVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
T84	M{fYfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoXyTWM2OD1{MT65PFE6KM7:TR?=	NIT3WXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
NCI-H630	NUD6SWhlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2fYXGlEPTB;MkKuOVM3OyEQvF2=	NYi4RlV1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
LU-165	NHW5fJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4PEUWlEPTB;MkKuOVU1KM7:TR?=	NEDmOYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
COLO-792	NIT2elhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFfTS2dKSzVyPUKyMlcyOTFizszN	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
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HCE-T	NHjnO\|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkfMTWM2OD1{Mj64OlA3KM7:TR?=	NY\mSmtwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
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LNCaP-Clone-FGC	NHP2c\|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3;6U2lEPTB;MkWuN\|Q6QCEQvF2=	M1TLc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
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OE33	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUj3cJhsUUN3ME2yOU43QDV\|IN88US=>	NEjEXJU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
HT-29	MlvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlnwTWM2OD1{NT63PFc6KM7:TR?=	M1ewbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
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LB373-MEL-D	NILHWFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWXuO2RxUUN3ME2yOk4yPzB6IN88US=>	NY\3dpFWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
NCI-H1436	MkTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIHMOI5KSzVyPUK2MlI4OzhizszN	NYrHToFGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
COLO-824	NXXiPXdmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWHJR\|UxRTJ4LkSwNFIh\|ryP	NFuxNVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
CP50-MEL-B	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MW\JR\|UxRTJ4LkW2O\|Uh\|ryP	MmHoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
EGI-1	NGDG[4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUnJR\|UxRTJ5LkK2PVgh\|ryP	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
LAN-6	MoTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{\YeWlEPTB;MkeuN\|U6QCEQvF2=	MnXJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
GAK	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVrJR\|UxRTJ5LkSyNlUh\|ryP	M{XNUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
MDA-MB-175-VII	M1jibmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2rGO2lEPTB;MkeuOVA2OyEQvF2=	NXLvOoZkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
JVM-2	NFPvPJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVjJR\|UxRTJ5Lk[2NlIh\|ryP	M{nKVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
UACC-257	NHfrUFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1S3[GlEPTB;MkeuOlg4QCEQvF2=	NVG0Rmd6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
SW1783	MkjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF;Yc2RKSzVyPUK3Mlc4QDNizszN	M3Hk[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
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BT-20	NYfNU3RST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn;HTWM2OD1{OT6wOVg3KM7:TR?=	M3L0cFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
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OMC-1	MnGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF;ve3NKSzVyPUOwMlE6OTlizszN	MmjFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
PFSK-1	NIKwVZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnXpTWM2OD1\|MT6yOlU6KM7:TR?=	M3fSflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
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NCI-H64	NWWyZnhbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{P1RmlEPTB;M{KuOFE4QSEQvF2=	MkfJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
DMS-114	NY\0TppKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVOwR3FwUUN3ME2zNk41OTh{IN88US=>	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
NCI-H661	MmS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWnJR\|UxRTN{Lk[1NFEh\|ryP	M4PTPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
CAL-148	M{W5dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1zIb2lEPTB;M{KuOlY3PSEQvF2=	M1rVdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
HuP-T3	NXj1WZlST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NETOe2RKSzVyPUOyMlk{OzhizszN	NF;rcIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
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Ca9-22	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnPJTWM2OD1\|Mz60OlAyKM7:TR?=	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
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NCI-H510A	NXvlXWlVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV\QV\|lmUUN3ME20OE44ODhizszN	NF7wfnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
LB2518-MEL	MmfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmWzTWM2OD12ND63PVM4KM7:TR?=	NH7RR2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
TE-5	M3\NfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXvJR\|UxRTR3Lkm1PFEh\|ryP	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
EW-24	NETrNGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF\EZpNKSzVyPUS2MlE4OjNizszN	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
LB647-SCLC	MkfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUfJR\|UxRTR4LkKxOVUh\|ryP	M3HhWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
NCI-H524	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVvTRWxUUUN3ME20Ok44OTh3IN88US=>	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>
EW-11	MmOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUnJR\|UxRTR4LkmzO\|Mh\|ryP	NXz2colLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
KALS-1	MkPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV;JR\|UxRTR5LkKwOlYh\|ryP	NU[4XJF{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
BT-474	NXjueWIzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlPDTWM2OD12Nz60NlE3KM7:TR?=	NXXKNmk5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
SK-N-AS	NIntdIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWL2WYtGUUN3ME20O{45QDhizszN	NFPHPJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
HCC2157	NXXNVFlqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHfnSnZKSzVyPUS4MlA4PiEQvF2=	NH;KZZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
HCC1954	MnTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVTJR\|UxRTR6LkG3NFQh\|ryP	NEXadVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
FADU	NHm5THNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFnJN3ZKSzVyPUS4MlMxOzFizszN	NX7GWXd1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
S-117	NXPY[ZVxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoL6TWM2OD12OD6zPFE2KM7:TR?=	NU\UUXZ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTF5MUizO{8oRlODTlfFVlww[T5?
LS-1034	M2DzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{XjUWlEPTB;NEiuO\|A3PyEQvF2=	NHfqdlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOTdzOEO3M{c,W0GQR1XSQE9iRg>?
CAMA-1	NGflVWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4rINmlEPTB;NEmuOVU1OyEQvF2=	MnzIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVE4OTh\|Nz:nQnNCVkeHUkyvZV4>
LU-134-A	NHTicHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWXJR\|UxRTR7LkiwPFUh\|ryP	M3:zfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEyPzF6M{evK\|5USU6JRWK8M4E,
NCI-H1838	MmrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWroW2pWUUN3ME20PU45ODh5IN88US=>	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNVcyQDN5Lze+V2FPT0WUPD;hQi=>

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	pSrc / Src / pPlcg / Plcg / pStat5 / Stat5 ; PubMed: 22781593 Leukemia In (B) inhibition of Src, Plcg and Stat5 was seen in MLNAF cell lines treated with Ponatinib; ZNF112 expresses ZMYM2–FGFR1, CEP2A and CEP5A cells express CEP110–FGFR1 and BBC2 expresses BCR–FGFR1. pFGFR1(pY20) / FGFR1; PubMed: 22781593 Leukemia Western blot analysis, using various antibodies specific for downstream targets of FGFR1, demonstrates that Ponatinib inhibits the activation of Plcg and Src as a result of inhibiting the FGFR1 fusion kinase in human KG1 cells. cleaved caspase-3 / cleaved caspase-7 / BAX / Bcl-2; PubMed: 30959969 Molecules Western blot analysis of cleaved caspase-3, cleaved caspase-7, Bax, Bcl-2, and β-Tubulin (control) in treated cells. p-Rb(S807/811) / Rb / CDK4 / CDK6 / Cyclin D1 / CDK2 / Cyclin E1; PubMed: 30959969 Molecules Western blot analysis of Rb/p-Rb, CDK4, CDK6, Cyclin D1, CDK2, Cyclin E1, and β-Tubulin (control) in the SK-Hep-1 and SNU-423 cells treated with ponatinib. RAD51; PubMed: 30959969 Molecules The effect of ponatinib on the concentration of Rad51 in SK-Hep-1 and SNU-423 cells. p-MEK / MEK / p-ERK / ERK; PubMed: 30959969 Molecules Effect of ponatinib on the phosphorylation of Mek and Erk. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control. c-Jun / p-JNK(T183/Y185) / JNK; PubMed: 30959969 Molecules Effect of ponatinib on the phosphorylation of JNK and c-Jun. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control. p-p38 MAPK / p38 MAPK; PubMed: 30959969 Molecules Effect of ponatinib on the phosphorylation of p38. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control. p-JAK2 / JAK2 / p-STAT3 / STAT3; PubMed: 30959969 Molecules Effect of ponatinib on the phosphorylation of Jak2, and Stat3. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control. PI3K p85 / p-PI3K / p-PDK1 / PDK1 / p-mTOR / mTOR; PubMed: 30959969 Molecules Effects of ponatinib on the protein concentration and phosphorylation of PI 3-kinase, PDK1, Akt, and mTOR in HCC cells. p-PDGFRα / PDGFRα; PubMed: 24472312 Mol Cancer Ponatinib inhibited phosphorylation of PDGFRα in a concentration-dependent manner. EOL-1 and BaF3-WT or -T674I FIP1L1-PDGFRα cells were exposed to escalating concentrations of ponatinib for 24 h. PARP / Caspase-3 / Active Caspase-3; PubMed: 24472312 Mol Cancer The concentration- (for 24 h) and time-dependent (1 nM for EOL-1, 300 nM for BaF3-WT and -T674I FIP1L1-PDGFRα cells) cleavage of PARP and caspase-3 triggered by ponatinib was analyzed by immunoblotting. AIF / Cyto C ; PubMed: 24472312 Mol Cancer Ponatinib elicited release of AIF and cytochrome c into the cytosol. Cells were treated with 1 nM ponatinib for the indicated durations and the cytosolic fraction was extracted with digitonin buffer. Levels of AIF and Cytochrome c (Cyto c) were detected by immunoblotting. Mcl-1 / Survivin / Bcl-Xl / XIAP / Bax / Bcl-2 / Bim; PubMed: 24472312 Mol Cancer Immunoblotting of apoptosis-related proteins in CEL cells after treatment for 24 h. β-catenin ; PubMed: 24472312 Mol Cancer Ponatinib concentration-dependently lowered β-catenin. EOL-1 cells were incubated with ponatinib for 24 h, and cytoplasmic and nuclear extracts were determined by immunoblotting. β-catenin; PubMed: 24472312 Mol Cancer Analysis of β-catenin localization. EOL-1 cells were pretreated with 1 nM ponatinib for 24 h, immunofluorescence analysis was performed with anti-β-catenin. Nuclei were stained with 4,6-diamidino-2-phenylindole (DAPI). ABL; PubMed: 19878872 Cancer Cell In vitro [γ-32P]-ATP autophosphorylation of full-length (A) ABL or (B) ABLT315I kinase treated with AP24534, imatinib, nilotinib, or dasatinib. After incubation of tyrosine-dephosphorylated enzyme with the indicated inhibitor in the presence of [γ-32P]-ATP and separation by SDS-PAGE, signal intensity was measured by autoradiography.	22781593 30959969 24472312 19878872
Growth inhibition assay	Cell viability; PubMed: 30174789 Oncotarget (A) Effect of Ponatinib on basal viability of HUVECs. The cells were treated with Ponatinib at indicated concentrations or 0.1% DMSO (vehicle control) for 24 h.	30174789

体内研究

Ponatinib抑制取自FLT3-ITD阳性AML病人的原代白血病细胞，而不抑制表达阴性FLT3的AML病人的白血病细胞。^[3]

激酶实验：^[1]	- 合并激酶实验: 通过同质时间分辨荧光共振能量转移法(TR-FRET)，使用纯化的人类野生型ABL激酶，T315I突变型ABL激酶，及生物素化的磷酸激酶底物肽: 生物素-EKKMAAEAIYAAPFAK-NH2，测定野生型ABL和T315I突变型ABL活性的抑制激酶反应在全LANCE激酶buffer (LKB)中进行，LKB包括20 mM NaHEPES（pH 为7.4）, 0.1 mg ⁄ mL BSA, 1 mM ATP, 10 mM MgCl₂, 及0.41 mM DTT，在提前用1% BSA（溶于PBS）包被的96孔板上4^oC下过夜。用于激酶反应，Ponatinib稀释物和野生型ABL, T315I突变型ABL (40 pM), 及底物肽(50 nM), 在室温下温育1小时（T315I突变型ABL）或2小时（野生型ABL）。加入15 nM 抑制剂, 6 nM 铕标记的磷酸酪氨酸抗体（磷酸化位点在第66为酪氨酸上），及60 nM 别藻蓝素标记的链酶亲和素，终止反应。实验板在室温下黑暗温育20分钟，使用Wallac Victor2V读数器读取615和665nm处的荧光值。在孔中数据平均值中插入抑制剂的3倍连续稀释液，再读取665nm处荧光值，计算IC50值。
细胞实验：^[1]	- 合并 Cell lines: Ba ⁄ F3细胞 Concentrations: 0-625 nM, 和0-10 µM Incubation Time: 72小时 Method: Ba/F3细胞系按每孔4×10³个细胞分布在96孔板上(4×10³)，和梯度浓度Ponatinib温育72小时。Ponatinib浓度范围为: 0-625 nM 作用于表达BCR-ABL细胞，0-10 µM 用于测定BCR-ABL阴性细胞。使用MTS实验测定细胞增殖，取三次平行实验平均值测定IC50值。 (Only for Reference)
动物实验：^[3]	- 合并 Animal Models: 皮下植入MV4-11细胞移植瘤(1×10⁷，50%基质胶中) 的雌性CB.17 SCID鼠 Dosages: 每天处理一次，持续4周 Administration: 口服饲喂处理 (Only for Reference)

参考文献

- 合并

溶解度 (25°C)

体外	DMSO	30 mg/mL (56.33 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 1% CMC Na	30mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Ponatinib (AP24534) SDF

分子量	532.56
化学式	C₂₉H₂₇F₃N₆O
CAS号	943319-70-8
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-05-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04554459	Recruiting	Drug: Ponatinib 15 MG Oral Tablet	Acute Lymphoblastic Leukemia Adult\|Ph+ ALL\|Newly Diagnosed	Institute of Hematology and Blood Transfusion Czech Republic\|CZECRIN - Czech Clinical Research Infrastructure Network	February 16 2021	Phase 2
NCT04160546	Recruiting	Drug: Ponatinib 15 MG\|Drug: Acetylsalicylic acid 100 MG	Chronic Myeloid Leukemia Chronic Phase	Fundacion CRIS de Investigación para Vencer el Cáncer\|Incyte Biosciences UK\|Apices Soluciones S.L.	January 17 2020	Phase 2
NCT03934372	Recruiting	Drug: Ponatinib	Acute Myeloid Leukemia\|Accelerated Phase Chronic Myeloid Leukemia\|Blast Phase Chronic Myeloid Leukemia\|Chronic Phase Chronic Myeloid Leukemia\|Acute Lymphoblastic Leukemia\|Acute Lymphocytic Leukemia\|Leukemia\|Lymphoma\|Solid Tumors	Incyte Biosciences International Sàrl\|Incyte Corporation	January 29 2020	Phase 1\|Phase 2
NCT04070443	Recruiting	Drug: Ponatinib\|Drug: Imatinib	Philadelphia Chromosome Positive CML\|BCR-ABL Positive Chronic Myelogenous Leukemia	Centre Leon Berard	November 13 2019	Phase 2
NCT03895671	Recruiting	Drug: Ponatinib\|Drug: Azacitidine	CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE\|CHRONIC MYELOGENOUS LEUKAEMIA IN MYELOID BLAST CRISIS	Versailles Hospital	June 19 2019	Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?
回答：
Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

选择性强的Bcr-Abl抑制剂

Nilotinib (AMN-107) : Bcr-Abl-selective, IC50<30 nM.
活性最高的Bcr-Abl抑制剂

GZD824 : Bcr-Abl(WT), IC50=0.34 nM; Bcr-Abl(T315I), IC50=0.68 nM.
FDA批准的Bcr-Abl抑制剂

Dasatinib : Approved by FDA for CML and Ph+ ALL.
最新的Bcr-Abl抑制剂

GZD824 : Orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

研究领域

产品类型

定制您的化合物库

Ponatinib (AP24534)

客户使用Selleck生产的Ponatinib (AP24534)发表文献146篇：

产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Ponatinib (AP24534) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-05-17)

技术支持

常见问题及建议解决方法

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

相关Bcr-Abl产品