Ponatinib (AP24534)

目录号：S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534)是一种新型有效的多靶点抑制剂，在无细胞试验中作用于Abl，PDGFRα，VEGFR2，FGFR1和Src，IC50分别为0.37 nM，1.1 nM，1.5 nM，2.2 nM和5.4 nM。

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RMB 819.31 现货
RMB 903.01 现货
RMB 3034.48 现货
RMB 7959.08 现货
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客户使用Selleck该产品发表文献31篇：

产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

产品描述 Ponatinib (AP24534)是一种新型有效的多靶点抑制剂，在无细胞试验中作用于Abl，PDGFRα，VEGFR2，FGFR1和Src，IC50分别为0.37 nM，1.1 nM，1.5 nM，2.2 nM和5.4 nM。
靶点
Abl [1]
(Cell-free assay)		 PDGFRα [1]
(Cell-free assay)		 VEGFR2 [1]
(Cell-free assay)		 FGFR1 [1]
(Cell-free assay)		 c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外研究

Ponatinib是有效的可用于口服的多靶点激酶抑制剂，作用于野生型细胞,及T315I 突变细胞IC50分别为1.2和8.8nM。[1] Ponatinib抑制Ba/F3衍生细胞系的增殖。[2] Ponatinib作用于表达野生型或T315I突变型BCR-ABL的CML细胞系，有效抑制BCR-ABL调节的信号。Ponatinib阻断在细胞瘤筛选时产生抗性突变。[3] Ponatinib也抑制VEGFR和FGFR家族激酶，在体外抑制FLT3, KIT, FGFR1,和PDGFRa激酶活性时IC50分别为13, 13, 2, 和1 nM.[4]Ponatinib抑制全部4种RTKs磷酸化，存在剂量依赖性，IC50值为0.3到20 nM。然而，Ponatinib抑制表达野生型FLT3的RS4;11细胞时IC50>100 nM。
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NUTG[ot[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPV[3lUUUN3ME2wMlAxODByMECzOVkh|ryP NWrsVZpDW0GQR1XS
MV-4-11 NUflWplyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvE[mNKSzVyPUCuNFAxODl3NjFOwG0> MoHXV2FPT0WU
MEG-01 M3TpT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTNTWM2OD1yLkCwNFEzQCEQvF2= NED4cnpUSU6JRWK=
LAMA-84 M4C4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYr0UWRrUUN3ME2wMlAxODF4NTFOwG0> MmqxV2FPT0WU
CGTH-W-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvNSmZKSzVyPUCuNFAyPjlizszN NX;HcnFpW0GQR1XS
KASUMI-1 NVnGXlYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\3dWdKSzVyPUCuNFAzOTdizszN Mn;wV2FPT0WU
BE-13 NVyzR|BbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMECyOVkh|ryP NHH5W5RUSU6JRWK=
CTV-1 MmLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DYdmlEPTB;MD6wNFUzOSEQvF2= NFrVdmZUSU6JRWK=
NKM-1 M3K4eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nzSmlEPTB;MD6wNFY2PSEQvF2= MWXTRW5ITVJ?
MONO-MAC-6 M1fHUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1L2fmlEPTB;MD6wNFg{PyEQvF2= MlziV2FPT0WU
A204 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMEGyNVgh|ryP NWrZdXU3W0GQR1XS
GDM-1 M4n6N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX:4U|V3UUN3ME2wMlAyQDN|IN88US=> NHflXodUSU6JRWK=
AN3-CA NHjJT2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETrRmpKSzVyPUCuNFE5PzNizszN MoOyV2FPT0WU
BL-70 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\BTWM2OD1yLkCyNVk6KM7:TR?= Mm\5V2FPT0WU
Daudi M3LRcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXhTWM2OD1yLkCyOVM4KM7:TR?= NHzKXppUSU6JRWK=
KU812 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXVSHBqUUN3ME2wMlAzQDR6IN88US=> MlLEV2FPT0WU
KG-1 NVzHPIt3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrLTWM2OD1yLkCzNlk1KM7:TR?= NU[ybIk6W0GQR1XS
DOHH-2 MkTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPXTWM2OD1yLkC0PFA{KM7:TR?= MVnTRW5ITVJ?
HuO9 NVSwUZJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHv1[IFKSzVyPUCuNFU1PDhizszN MUjTRW5ITVJ?
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G-402 NUfWOWU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwME[zOFEh|ryP NV31V|V6W0GQR1XS
SU-DHL-1 M3jFVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzoNWZKSzVyPUCuNFY{PzlizszN NILKWoFUSU6JRWK=
NCI-H719 M4rmVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknETWM2OD1yLkC3PFg5KM7:TR?= M{O1WXNCVkeHUh?=
MLMA MlvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NESwPFhKSzVyPUCuNFkxPiEQvF2= NI\Nb3lUSU6JRWK=
KM12 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILxOWZKSzVyPUCuNFk4OzdizszN MW\TRW5ITVJ?
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MFE-296 NFO3OWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XOWmlEPTB;MD6xNVg{QSEQvF2= M4[wPHNCVkeHUh?=
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MPP-89 Mk\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4KwOmlEPTB;MD6xOlk{OyEQvF2= MYfTRW5ITVJ?
SF126 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMUewOlMh|ryP NFjMcJpUSU6JRWK=
CTB-1 M1vTc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIH5XXBKSzVyPUCuNVc{OTZizszN MnLqV2FPT0WU
CA46 NH7wS3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXaZmN[UUN3ME2wMlE4PDh7IN88US=> M4rRbXNCVkeHUh?=
NCI-H520 NUfsUXFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMUe3N|Ih|ryP MlfVV2FPT0WU
CAL-85-1 NXTMXVM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLCTWM2OD1yLkG3PVI4KM7:TR?= MUPTRW5ITVJ?
NCI-H2342 NXK1do1nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIK2TmJKSzVyPUCuNVg2PzdizszN NUi4OmJyW0GQR1XS
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NY NI[5WItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XhNmlEPTB;MD6xPVI5PyEQvF2= MoqyV2FPT0WU
T98G MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r4dmlEPTB;MD6xPVMyQCEQvF2= NGixNGdUSU6JRWK=
NCI-H1703 NHHRXmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMUm2NVUh|ryP MnfPV2FPT0WU
NCI-H2087 M{XmSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYKwXIpJUUN3ME2wMlIxPDN7IN88US=> NFjxOpNUSU6JRWK=
PF-382 NF\p[XFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfwWI1KSzVyPUCuNlA5PzNizszN NVnR[HRHW0GQR1XS
HCT-116 Mn6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMkGwOlkh|ryP MmfkV2FPT0WU
CAKI-1 NHzoNWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjyWYlKSzVyPUCuNlE3PjZizszN MYTTRW5ITVJ?
CCF-STTG1 M3Th[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\sPItKSzVyPUCuNlI1PzVizszN MVLTRW5ITVJ?
D-392MG MlznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;6PJFiUUN3ME2wMlI{OTd5IN88US=> NWTKdZlkW0GQR1XS
RT-112 M2j1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMkO3PVUh|ryP NXnh[3JZW0GQR1XS
MES-SA M2r3emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1S5dmlEPTB;MD6yOFE5PyEQvF2= MXHTRW5ITVJ?
LC-2-ad NUi5dZM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\UTWM2OD1yLkK0NlY2KM7:TR?= MnPNV2FPT0WU
NOS-1 MlKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4S2NGlEPTB;MD6yOFM3PyEQvF2= NHT5NoRUSU6JRWK=
NALM-6 Mn7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHWdJFMUUN3ME2wMlI2PTR|IN88US=> NE\SeoJUSU6JRWK=
TE-15 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3S0R2lEPTB;MD6yOlA6OSEQvF2= NUPLcI13W0GQR1XS
786-0 MoPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMk[yNlgh|ryP MoTOV2FPT0WU
IST-MES1 M{DmXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmeyTWM2OD1yLkK2PFI6KM7:TR?= NVy0TWV3W0GQR1XS
KYSE-180 NYnZNW5JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DpS2lEPTB;MD6yOlg6OSEQvF2= NGXXUIdUSU6JRWK=
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HuH-7 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPRTWM2OD1yLkK3O|Y{KM7:TR?= NHPQWVRUSU6JRWK=
CAS-1 NFu5copIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2X1WGlEPTB;MD6yPFMxOyEQvF2= NWC1Z4V7W0GQR1XS
KURAMOCHI NGHHSXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT2VY5XUUN3ME2wMlI5PDF7IN88US=> MnzGV2FPT0WU
ACHN M{Lq[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjYd2h1UUN3ME2wMlI6OzJ|IN88US=> MmTEV2FPT0WU
HGC-27 M{L4Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;D[mlEPTB;MD6yPVM2OyEQvF2= NHXTepZUSU6JRWK=
A172 MkK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfVTWM2OD1yLkK5OVc4KM7:TR?= NHvQZYJUSU6JRWK=
SNU-449 NY\OOG52T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\BToRKSzVyPUCuNlk6PjRizszN NH3VdndUSU6JRWK=
SW982 M1Swb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPJdWVKSzVyPUCuNlk6PzhizszN MWXTRW5ITVJ?
EFO-21 MnfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwM{C0NVEh|ryP MVTTRW5ITVJ?
NCI-H2030 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwM{GxOlQh|ryP NIrUbG1USU6JRWK=
HT-144 NYfvbHpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zhR2lEPTB;MD6zNVI5KM7:TR?= MkPCV2FPT0WU
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NCI-H2052 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4j6fmlEPTB;MD6zNVQ5PCEQvF2= MoPHV2FPT0WU
SK-HEP-1 M3rPZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j6WWlEPTB;MD6zN|M3QCEQvF2= M1nWZnNCVkeHUh?=
QIMR-WIL Mmq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfVVHFZUUN3ME2wMlM{PDJ2IN88US=> NYnHRopFW0GQR1XS
A2780 M3jr[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfrUmVUUUN3ME2wMlM1OzB2IN88US=> M2LEO3NCVkeHUh?=
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BxPC-3 MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HvOWlEPTB;MD6zOFk5QSEQvF2= Ml[yV2FPT0WU
BCPAP MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnwTnZOUUN3ME2wMlM3ODBzIN88US=> NWL4ZYV1W0GQR1XS
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SW1417 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LQOGlEPTB;MD61Nlc5OSEQvF2= Mn3hV2FPT0WU
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ECC12 MmPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;CXGlEPTB;MD61OlU2QCEQvF2= MUnTRW5ITVJ?
CHL-1 NILvSJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3wOIZKSzVyPUCuOVc1PjNizszN M{fJN3NCVkeHUh?=
LCLC-103H MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\yZXlKSzVyPUCuOVg{PDRizszN MmLOV2FPT0WU
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A3-KAW NVO4eZVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnKOYVoUUN3ME2wMlYyPDZ5IN88US=> M4TxR3NCVkeHUh?=
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GI-ME-N MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37uTWlEPTB;MD62N|A3QSEQvF2= NH7iOYlUSU6JRWK=
ES6 Mn\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwNkOyPVUh|ryP Mo\nV2FPT0WU
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HOP-92 M17aNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1P6b2lEPTB;MD62OVY4OiEQvF2= NHS5O3hUSU6JRWK=
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EW-13 NHnvRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPETWM2OD1yLk[2O|c6KM7:TR?= MY\TRW5ITVJ?
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JiyoyeP-2003 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTjc5RiUUN3ME2wMlY6PzN6IN88US=> MVHTRW5ITVJ?
WSU-NHL MnzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwN{C4PFch|ryP NXT4[WlxW0GQR1XS
U-698-M NFzz[5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFS2bJVKSzVyPUCuO|ExPjNizszN NYLaNpF3W0GQR1XS
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8505C M1HMeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWL3W3U4UUN3ME2wMlczPzRzIN88US=> NUOyZYZpW0GQR1XS
HUTU-80 NYT5Vlh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwN{OzOFkh|ryP MnzTV2FPT0WU
LB1047-RCC MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIq1XHpKSzVyPUCuO|M2OzhizszN NW[3[FhoW0GQR1XS
GAMG Mki3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTZTWM2OD1yLkezOlU{KM7:TR?= Mnq4V2FPT0WU
CAL-12T MoPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrVTWM2OD1yLkezPFc4KM7:TR?= Mnr5V2FPT0WU
NCI-SNU-1 NXTmfG5tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwN{eyO|gh|ryP NED6cJhUSU6JRWK=
HTC-C3 MlLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwN{e0OVEh|ryP NIXVWVVUSU6JRWK=
HPAF-II MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwN{e1NFEh|ryP M4LjR3NCVkeHUh?=
KGN M2jkS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGL0cGRKSzVyPUCuO|gxQDFizszN NGH2VWRUSU6JRWK=
EFO-27 MoqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fWXWlEPTB;MD63PFc{OyEQvF2= M1nOSHNCVkeHUh?=
MEL-HO NVPMPYk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwN{m0OFkh|ryP M1[3ZXNCVkeHUh?=
KYSE-270 NIHQS4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXKTWM2OD1yLkiwOVI6KM7:TR?= NFfRN4hUSU6JRWK=
NCI-H1755 NVmycFFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\IXGlEPTB;MD64NFcyPCEQvF2= NITuWodUSU6JRWK=
MFM-223 M3i3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHu0NYRKSzVyPUCuPFE1ODdizszN MWrTRW5ITVJ?
G-361 Ml\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwOEG4PVch|ryP NXrKW2plW0GQR1XS
ETK-1 Mme1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTjZWIxUUN3ME2wMlgzPDRzIN88US=> M2fqeHNCVkeHUh?=
LU-99A NWTpdGt1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;5W|FxUUN3ME2wMlg1PzBzIN88US=> MljDV2FPT0WU
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L-540 MkK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXydWRKSzVyPUCuPFU5ODFizszN NXv4fIxjW0GQR1XS
U-2-OS M1qyNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vmW2lEPTB;MD64OVg1PiEQvF2= NVf2dpA6W0GQR1XS
HT-1376 NWO1U4t1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwOE[wOVEh|ryP M3G2c3NCVkeHUh?=
COLO-680N NG\pNHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwOEe5N|Mh|ryP MWrTRW5ITVJ?
NCI-H1581 Mk[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MomxTWM2OD1yLki5Nlk4KM7:TR?= NX3QRXI2W0GQR1XS
HuCCT1 NVXnTlVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLZXZZKSzVyPUCuPFk2PDhizszN MWLTRW5ITVJ?
BB30-HNC M2f1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEG0V2VKSzVyPUCuPVI1PjlizszN NIm1[4VUSU6JRWK=
NCI-H2347 M2DySWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHSTWM2OD1yLkmzNlkzKM7:TR?= MXHTRW5ITVJ?
G-401 NHLiRoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTsTWM2OD1yLkmzOlk2KM7:TR?= M4LFbnNCVkeHUh?=
NCI-H358 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG3V2VKSzVyPUCuPVUxOTRizszN NYDHfXJUW0GQR1XS
HCC1395 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHaTWM2OD1yLkm1OFYyKM7:TR?= NVvFOI5DW0GQR1XS
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KE-37 NIDzcXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHXT2FRUUN3ME2wMlk3Ozh5IN88US=> NGjERVBUSU6JRWK=
NOMO-1 M1;LVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwOU[1OlQh|ryP M4T2dXNCVkeHUh?=
ML-2 M3\FV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoruTWM2OD1yLkm5O|Uh|ryP M{XNTXNCVkeHUh?=
SW872 MkDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\NPGlEPTB;MD65PVc4PSEQvF2= NEnMVYtUSU6JRWK=
KYSE-520 NInCZVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7VVXpKSzVyPUGuNFA1QTRizszN Mkj4V2FPT0WU
HL-60 M4TYPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvsdpJOUUN3ME2xMlAxQTdizszN M4Pk[HNCVkeHUh?=
HDLM-2 NGXleINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTFwMEGyOVIh|ryP MXzTRW5ITVJ?
MIA-PaCa-2 NXXxR5RnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTFwMEGzO|Uh|ryP NFnMSVlUSU6JRWK=
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SH-4 NX7zXFVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIGzeGZKSzVyPUGuNFIzPDRizszN MXTTRW5ITVJ?
MG-63 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;2TWM2OD1zLkCyOlE3KM7:TR?= M2HlSnNCVkeHUh?=
NB6 NIHLR3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTUTWM2OD1zLkCzNVA6KM7:TR?= MmjBV2FPT0WU
CAL-54 M13CbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2r0OmlEPTB;MT6wN|k2QSEQvF2= Ml\OV2FPT0WU
DU-145 NVXpWHoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDWU|BKSzVyPUGuNFgxPzNizszN NYPhRWZkW0GQR1XS
HCE-4 M2W4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn:xTWM2OD1zLkC5Nlg3KM7:TR?= Mn3jV2FPT0WU
U-266 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTFwMEm2N|Mh|ryP M37yWHNCVkeHUh?=
HT-1197 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTFwMUG0N|gh|ryP MUnTRW5ITVJ?
EW-1 NEO5dWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3P6SWlEPTB;MT6xOFEzQCEQvF2= MX7TRW5ITVJ?
MHH-NB-11 NXToU4VDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfxTWM2OD1zLkG1N|Y5KM7:TR?= MkPiV2FPT0WU
NCI-H2405 Mk[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTFwMU[xOkDPxE1? NH:0ZYVUSU6JRWK=
COLO-668 NU\3OHhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInyUXNKSzVyPUGuNVY1QSEQvF2= NXPaXG9CW0GQR1XS
IMR-5 M2PDWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPnXHV{UUN3ME2xMlE3QTN4IN88US=> Mn;qV2FPT0WU
ARH-77 MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTFwMkK5NlQh|ryP MUfTRW5ITVJ?
BHT-101 NGGxWZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3JdVN[UUN3ME2xMlI{PDlizszN NW\2UVBWW0GQR1XS
SCC-25 NH:0Ro9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWD5fYNQUUN3ME2xMlI{PTN4IN88US=> MlKxV2FPT0WU
NTERA-S-cl-D1 NYHjfmlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnGcWlsUUN3ME2xMlI1OzR4IN88US=> MmP2V2FPT0WU
MKN28 NFrJeXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWThe2JNUUN3ME2xMlI2PjN4IN88US=> MofQV2FPT0WU
KS-1 NIPPUYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmraTWM2OD1zLkK4NlY6KM7:TR?= MUjTRW5ITVJ?
NCI-H1734 NXPPbJg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3P6UGlEPTB;MT6yPFkyOyEQvF2= MWHTRW5ITVJ?
ES7 NVHoeGExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moi0TWM2OD1zLkK5OVQzKM7:TR?= MXfTRW5ITVJ?
NCI-H838 M1[wNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTFwM{C2NVUh|ryP MljpV2FPT0WU
HEC-1 MoXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTFwM{O3OVUh|ryP M{L3NXNCVkeHUh?=
ME-180 Mn3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVG1bHdGUUN3ME2xMlM4QTl|IN88US=> NHTCVG5USU6JRWK=
MMAC-SF MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3NTWM2OD1zLkO5OVk2KM7:TR?= MXTTRW5ITVJ?
IA-LM NWr1ZmtGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlyxTWM2OD1zLkSwPVE1KM7:TR?= MnywV2FPT0WU
MN-60 NGPrSXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYC1[Gp4UUN3ME2xMlQ{OTF2IN88US=> NHjsOHVUSU6JRWK=
SIMA MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DWW2lEPTB;MT60PFY5PyEQvF2= MWLTRW5ITVJ?
NCI-H1770 M1rteGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7JTWM2OD1zLkWyNFU1KM7:TR?= M3HVc3NCVkeHUh?=
ONS-76 NX[1b|A1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Cyc2lEPTB;MT61NlMyOSEQvF2= MnvLV2FPT0WU
LB771-HNC NIHBU5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTFwNUO5NFYh|ryP NEm4N4tUSU6JRWK=
SW48 MonkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnRboxKSzVyPUGuOVQzPDNizszN NITZZnRUSU6JRWK=
KYSE-140 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXuO3lvUUN3ME2xMlU2PzRzIN88US=> MVzTRW5ITVJ?
SW626 Mk\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2[5VmlEPTB;MT61PFE3KM7:TR?= M2i1enNCVkeHUh?=
MC-CAR NFXtclNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTFwNUi2OlMh|ryP NXPWSXplW0GQR1XS
D-336MG MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTFwNkK5OEDPxE1? NInYVHVUSU6JRWK=
SK-MEL-3 NVSyS4Z6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnHSY5KSzVyPUGuOlM6ODJizszN NU\uU2hnW0GQR1XS
MHH-PREB-1 NG\K[3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrLTWM2OD1zLk[0OFc{KM7:TR?= MUPTRW5ITVJ?
Calu-1 M1vnNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTtTWM2OD1zLk[1N|g3KM7:TR?= MlrqV2FPT0WU
HCC1806 NET5UZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrtcZdVUUN3ME2xMlY3PjFzIN88US=> NUHF[lhkW0GQR1XS
A101D MkPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrhR2tKSzVyPUGuOlY4QDFizszN MUXTRW5ITVJ?
A704 NH3j[XhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHLd5NKSzVyPUGuOlg{OTFizszN M2jI[nNCVkeHUh?=
LB831-BLC M2fXbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjLVWZKSzVyPUGuOlk5PTRizszN NF;GeI1USU6JRWK=
RL95-2 MoS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTFwN{G0OlMh|ryP NXvCdo85W0GQR1XS
RPMI-2650 MofwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nCZmlEPTB;MT63NlcyQSEQvF2= NXPaW251W0GQR1XS
NH-12 Mkn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUm2WXdkUUN3ME2xMlc{PDJ5IN88US=> MWXTRW5ITVJ?
AGS M1vScGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXe1ZYZPUUN3ME2xMlc3OzV6IN88US=> MWHTRW5ITVJ?
NEC8 NYPTVIV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH2xUFNKSzVyPUGuO|g6QTVizszN M4rjTHNCVkeHUh?=
NCI-H2009 NIf3Z5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTFwN{m3NlEh|ryP NITweZNUSU6JRWK=
A498 NXTZfXEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHyZWFQUUN3ME2xMlgyOjh{IN88US=> MV3TRW5ITVJ?
NCI-H810 M4frfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTBNXVMUUN3ME2xMlgyPjB4IN88US=> NVzEVFNmW0GQR1XS
SK-NEP-1 NXnYcGVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPGTWM2OD1zLkizO|Y4KM7:TR?= NILweVJUSU6JRWK=
D-542MG M2XWXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4S4WmlEPTB;MT64OVg2OSEQvF2= MoT3V2FPT0WU
KNS-42 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTFwOE[yOlYh|ryP M1XBT3NCVkeHUh?=
NCI-H2452 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\wU4hbUUN3ME2xMlg6ODd2IN88US=> MWHTRW5ITVJ?
SK-MEL-2 NWHIeoVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHsd2huUUN3ME2xMlkxOjdzIN88US=> MXHTRW5ITVJ?
OVCAR-5 MmD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvvVVcyUUN3ME2xMlkxPjd3IN88US=> Mo\CV2FPT0WU
SNG-M NXvUfJM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfPNYVGUUN3ME2xMlk2QDV6IN88US=> M{LWdnNCVkeHUh?=
A673 NFWxcXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLyOGNNUUN3ME2xMlk4PTF4IN88US=> M4jCTHNCVkeHUh?=
L-428 MkjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXs[HZRUUN3ME2xMlk6OTd7IN88US=> MXTTRW5ITVJ?
KM-H2 NG\WO5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rPRWlEPTB;Mj6wNVA6KM7:TR?= NVTlcmZCW0GQR1XS
MC-IXC M{f5e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTJwMEKyO|Mh|ryP NF3tVIRUSU6JRWK=
COLO-678 MmjSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmiwTWM2OD1{LkC0NlA4KM7:TR?= MYLTRW5ITVJ?
MEL-JUSO NH;GNYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\TTWM2OD1{LkC3PFUyKM7:TR?= NWTjfpBbW0GQR1XS
HCC38 NIXuOZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrNTWM2OD1{LkC4OFM{KM7:TR?= Mlq3V2FPT0WU
UACC-62 NXviZ5lUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX36dmpmUUN3ME2yMlA5QDV3IN88US=> NFPyPZJUSU6JRWK=
OAW-42 M4fKN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTJwMEm3NVEh|ryP NX7qUFVNW0GQR1XS
LB996-RCC MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHLcpNKSzVyPUKuNVM5OTdizszN NIrSPFFUSU6JRWK=
COR-L105 M{T5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3S0RWlEPTB;Mj6xOlM4OyEQvF2= MmfmV2FPT0WU
RCC10RGB MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1n3VmlEPTB;Mj6xPFU4PiEQvF2= Ml3zV2FPT0WU
A431 NVjSVmNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HjUmlEPTB;Mj6xPVAyQSEQvF2= M1fCfHNCVkeHUh?=
NCI-H292 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjJVVRKSzVyPUKuNlM6PTFizszN MojGV2FPT0WU
SK-UT-1 NU\HbWZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTJwM{OxPFQh|ryP MkHiV2FPT0WU
PANC-08-13 MkDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXHTWM2OD1{LkOzNlM2KM7:TR?= MVTTRW5ITVJ?
ST486 NHzrdGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfDTWM2OD1{LkSxNFQ5KM7:TR?= MUHTRW5ITVJ?
SJSA-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrGfJlKSzVyPUKuOFEzPzFizszN Mn3aV2FPT0WU
RKO M1f1R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnnfIxEUUN3ME2yMlQzODJ7IN88US=> NW\FN5F6W0GQR1XS
NCI-H1793 Mmq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTJwNESwNlkh|ryP NUjr[4pWW0GQR1XS
639-V MnntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTJwNEWzPFIh|ryP MWHTRW5ITVJ?
ES3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XpTGlEPTB;Mj60PVc{PyEQvF2= NF7NNJJUSU6JRWK=
NCI-H1792 Ml3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\3NGx2UUN3ME2yMlU3QDJ4IN88US=> M321fnNCVkeHUh?=
NCI-H1651 MkD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzKZnlNUUN3ME2yMlU5OjFizszN NVSxNJBmW0GQR1XS
SN12C NWC4O2FzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfLXm9KSzVyPUKuOVg1QDdizszN MmK2V2FPT0WU
COLO-679 M4LyZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3rWYxoUUN3ME2yMlU5PjB3IN88US=> Mmj6V2FPT0WU
U-118-MG MlTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfSZ29lUUN3ME2yMlU5QDd{IN88US=> NWTHcVM5W0GQR1XS
Ramos-2G6-4C10 NXrIS|ZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrkeIVFUUN3ME2yMlY1QDB5IN88US=> MXrTRW5ITVJ?
HCT-15 NWiyPVRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTvSGVKSzVyPUKuOlg4QTJizszN MVHTRW5ITVJ?
MDA-MB-157 MlvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\afWlEPTB;Mj63NFc1PyEQvF2= NUT5UIhzW0GQR1XS
K5 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rP[2lEPTB;Mj63NVg1PSEQvF2= MUHTRW5ITVJ?
MKN45 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3W2XGlEPTB;Mj63N|M3PiEQvF2= NEnEdHdUSU6JRWK=
DMS-273 M33lUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkflTWM2OD1{Lke1OlMzKM7:TR?= NEfFOGVUSU6JRWK=
C8166 NWCzO2xXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmX4TWM2OD1{Lke4OVE{KM7:TR?= NWDLSpJJW0GQR1XS
Calu-3 NV3MV3hlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTJwN{i5Olkh|ryP NEXVZ41USU6JRWK=
SNB75 NGLvNWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnKSnp6UUN3ME2yMlg5PTN3IN88US=> NXT6NYMyW0GQR1XS
BFTC-905 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:5SmlEPTB;Mj65NFE6OSEQvF2= MYDTRW5ITVJ?
C-4-II NUHnbFRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPOWZdDUUN3ME2yMlkyOzV|IN88US=> Mn3ZV2FPT0WU
MS-1 NX[3bHN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVO4[ohOUUN3ME2yMlk3PzZ7IN88US=> MX3TRW5ITVJ?
A375 NEnDNVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1uxOmlEPTB;Mz6wPFE5PCEQvF2= M17DdXNCVkeHUh?=
KYSE-70 NFf0T2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7FbpJKSzVyPUOuNFg5QDJizszN Mmr4V2FPT0WU
KYSE-510 NWnOSFlUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rFdGlEPTB;Mz6xNFk6PSEQvF2= MmHVV2FPT0WU
LN-405 Mkn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1WzUWlEPTB;Mz6xN|UyQCEQvF2= NH3WWZlUSU6JRWK=
BOKU MmT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTNwMUSyOVYh|ryP NHTs[Y5USU6JRWK=
TE-10 M3;EW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYP4SGVHUUN3ME2zMlE4OzZ{IN88US=> NEn1WlRUSU6JRWK=
MKN1 MnHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfuVndKSzVyPUOuNVg1QDNizszN MULTRW5ITVJ?
M059J NGC4V2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPZTWM2OD1|LkKwNVc{KM7:TR?= M4HERnNCVkeHUh?=
GOTO NFr0epRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;hTWM2OD1|LkKyNFM6KM7:TR?= NGO5U|VUSU6JRWK=
DK-MG MnvhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rCbWlEPTB;Mz6yOVk4PiEQvF2= MUHTRW5ITVJ?
NCI-H727 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYe4SGJ2UUN3ME2zMlI3PThizszN NWXFUVVDW0GQR1XS
NB12 M1fMUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\6O4x7UUN3ME2zMlM{OjJ2IN88US=> NYDUWYtYW0GQR1XS
DOK NGHjT21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfRNHFtUUN3ME2zMlM3OTh4IN88US=> NFXUXpNUSU6JRWK=
KYSE-410 M3fQOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILxUXVKSzVyPUOuN|YzQDdizszN M4ToRXNCVkeHUh?=
AM-38 NIexSVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nXWmlEPTB;Mz6zPFA2OSEQvF2= MXrTRW5ITVJ?
GR-ST M{jrZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTNwNEW3N|Ih|ryP M{TsOnNCVkeHUh?=
D-247MG M3PLbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\nVll1UUN3ME2zMlQ5OjZ|IN88US=> NITpPFJUSU6JRWK=
TE-8 MmC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rsPGlEPTB;Mz60PVM{OyEQvF2= MlvnV2FPT0WU
LS-411N MlrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEe1U|VKSzVyPUOuOFk3QTJizszN MWrTRW5ITVJ?
SK-MES-1 MojXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFP1TZFKSzVyPUOuOVY1OzNizszN NVrJSIxtW0GQR1XS
SF295 MknnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlT6TWM2OD1|Lk[xOVUzKM7:TR?= M3rPR3NCVkeHUh?=
SK-MEL-30 NELlTXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXn1eZFSUUN3ME2zMlY2QTJzIN88US=> Mnq0V2FPT0WU
LB2241-RCC NVr6Z5JzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTuPFBKSzVyPUOuOlYzPiEQvF2= NVLoe3U2W0GQR1XS
PC-14 NHTQRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LTWGlEPTB;Mz62OlQ{PyEQvF2= MlG4V2FPT0WU
EW-7 NIG5b|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3X2[2lEPTB;Mz62O|Y6OyEQvF2= Mn[yV2FPT0WU
NMC-G1 NGHKNo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkj3TWM2OD1|LkexPFM4KM7:TR?= MoHxV2FPT0WU
TE-441-T MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmKwTWM2OD1|LkezNFI5KM7:TR?= NFnENmxUSU6JRWK=
NCI-H1618 Mo\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrZfoN6UUN3ME2zMlgyQDd3IN88US=> NUX4fJFPW0GQR1XS
PANC-03-27 M1PnV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvs[4tOUUN3ME2zMlgyQTF4IN88US=> NYna[Y9WW0GQR1XS
NCI-H2228 NWHVWplxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVr4OYJrUUN3ME2zMlg{OTJ4IN88US=> MULTRW5ITVJ?
CAPAN-1 NX[5fZZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jPVGlEPTB;Mz64O|AxQSEQvF2= MVPTRW5ITVJ?
KLE MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrPXndZUUN3ME2zMlkxPjdizszN M12zNHNCVkeHUh?=
Becker NIX4N4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTNwOUK4OFkh|ryP NIjKVlRUSU6JRWK=
SK-PN-DW MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjYTWM2OD12LkC3PVc1KM7:TR?= MY\TRW5ITVJ?
Hs-578-T NWHHNZhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1j1XmlEPTB;ND6wPFMxPiEQvF2= NIrlbXJUSU6JRWK=
RS4-11 M1r1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHROJdIUUN3ME20MlEyOjV3IN88US=> M1S1eXNCVkeHUh?=
D-502MG M2m2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHFTnVKSzVyPUSuNVY6QTdizszN NWjFdIxCW0GQR1XS
GI-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Px[GlEPTB;ND6yPFI6QSEQvF2= MnWxV2FPT0WU
NCI-H209 NUjXbo9DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;0ZmlEPTB;ND6zN|c5KM7:TR?= NVrPUW14W0GQR1XS
SK-OV-3 MoTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\V[WlEPTB;ND60PFE1QSEQvF2= MoPiV2FPT0WU
LOUCY NX;o[XF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\BVJNKSzVyPUSuOFg1OzJizszN MX7TRW5ITVJ?
NCI-H69 NYnt[HM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zTdmlEPTB;ND61NVc6OyEQvF2= MY\TRW5ITVJ?
SCC-9 NHfFS2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTRwNUOxO|Ih|ryP M{TQNXNCVkeHUh?=
NCI-H526 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmm3TWM2OD12LkW5Nlk{KM7:TR?= NF3DcoxUSU6JRWK=
NCI-H2170 NX[zUZA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DYVWlEPTB;ND62Olc4OSEQvF2= Mlm3V2FPT0WU
SR NFS4VHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTRwN{CwOFgh|ryP NHjsNZFUSU6JRWK=
CMK MnTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTRTWM2OD12LkeyNVAyKM7:TR?= MkjHV2FPT0WU
COLO-829 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7xTWM2OD12Lke3NFQ{KM7:TR?= M3rOOXNCVkeHUh?=
HuO-3N1 NHvl[HpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrQbJdKSzVyPUSuPFMzQDFizszN NXzlN3h[W0GQR1XS
5637 M2XMZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTRwOUC0PFch|ryP NH23eWxUSU6JRWK=
A253 M3zqe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TLd2lEPTB;ND65O|cxQCEQvF2= M4DzNnNCVkeHUh?=
NB10 NXLMU4piT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPIdYJWUUN3ME21MlA4PDl5IN88US=> MW\TRW5ITVJ?
SF539 NIX0RpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkWzTWM2OD13LkC5PVU6KM7:TR?= M3\ZS3NCVkeHUh?=
HAL-01 NVLzcYd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXyT5R4UUN3ME21MlE1PjR3IN88US=> NETIS2lUSU6JRWK=
MHH-ES-1 M2C1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjkbWtKSzVyPUWuNVY6OjVizszN NFrscZNUSU6JRWK=
DEL MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;VXppXUUN3ME21MlI4PTh{IN88US=> NIXQW4VUSU6JRWK=
NCI-H1299 NW\v[GdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXyTWM2OD13LkO1NFA4KM7:TR?= MULTRW5ITVJ?
ChaGo-K-1 NETLWotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFf3RVNKSzVyPUWuN|UyODdizszN M3mySHNCVkeHUh?=
HMV-II MmX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTVwM{m0N{DPxE1? MYfTRW5ITVJ?
NB69 NHPuWm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33UUmlEPTB;NT6zPVY{OSEQvF2= NY\qPXl4W0GQR1XS
NCI-H1882 M{nZXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXxTWM2OD13LkSzN|Y1KM7:TR?= NFHyWFlUSU6JRWK=
SNU-475 Mn:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkT0TWM2OD13LkS3NVcyKM7:TR?= MnnLV2FPT0WU
RXF393 NFnYe3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\RTWM2OD13LkS4OFk1KM7:TR?= NIXrOmtUSU6JRWK=
CAL-51 NFHzbGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XhUWlEPTB;NT62Nlg2OyEQvF2= M2TxVnNCVkeHUh?=
SW1573 MlnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfDcGdKSzVyPUWuOlM2OzRizszN M3\OWHNCVkeHUh?=
GCT NF3oWYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vpUGlEPTB;NT63OVkzQSEQvF2= M1q1bnNCVkeHUh?=
COR-L88 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTVwN{[4OFYh|ryP NWW0fFd1W0GQR1XS
MDA-MB-134-VI NVi4OI1QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\EW2xKSzVyPUWuPFc2OzZizszN M{nke3NCVkeHUh?=
NB5 NHGxdlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUn0SG51UUN3ME21MlkzPDRizszN NUX5O4FzW0GQR1XS
GMS-10 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\LNpNKSzVyPUWuPVY5PjFizszN Mn\CV2FPT0WU
CHP-212 Mk[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13ob2lEPTB;Nj60PFI3PyEQvF2= NGe4UYpUSU6JRWK=
TE-11 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYD1SpNbUUN3ME22MlU2OTh{IN88US=> MWfTRW5ITVJ?
SW962 MkT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLOTWM2OD14Lk[1O|c1KM7:TR?= MoTWV2FPT0WU
MZ2-MEL NESyW|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moq1TWM2OD14LkiyNFEyKM7:TR?= MoPBV2FPT0WU
C-33-A M3qwS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\Se|NZUUN3ME22MlkyPjh6IN88US=> MkXsV2FPT0WU
IGR-1 Mn3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVexS3NXUUN3ME22Mlk4QDJ4IN88US=> NVzD[mVtW0GQR1XS
MOLT-4 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfJTWM2OD15LkG1OFA3KM7:TR?= MofCV2FPT0WU
NCI-H1650 NF:4OpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvIXWVKSzVyPUeuNlcxPDZizszN NWfpWFI{W0GQR1XS
AsPC-1 NIjnPZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjFNm9KSzVyPUeuNlg3ODVizszN M4myRXNCVkeHUh?=
SNU-C2B NGPVemdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHCUJNKSzVyPUeuNlk2PzFizszN M3LFZXNCVkeHUh?=
MKN7 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYOyU3VVUUN3ME23MlM4OjN3IN88US=> NX\BbY4{W0GQR1XS
SW620 MoSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHyTWM2OD15LkO4NlA2KM7:TR?= M2\xb3NCVkeHUh?=
SK-MEL-28 NV\ROFc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NED4dHBKSzVyPUeuOFA4QThizszN MVfTRW5ITVJ?
TE-6 NYHGbnJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;nXVdKSzVyPUeuOFQ6ODhizszN NHnuNWpUSU6JRWK=
D-263MG NF;LeVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HtNmlEPTB;Nz60OVc3OiEQvF2= M3fPe3NCVkeHUh?=
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U251 MoW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LafWlEPTB;MkSuNFY3QCEQvF2= MWrTRW5ITVJ?
LoVo MoXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HoV2lEPTB;MkSuPVI5OiEQvF2= MXXTRW5ITVJ?
GCIY NIjMWWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTXTWM2OD1{NT6yPFc4KM7:TR?= MV7TRW5ITVJ?
NUGC-3 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nSTWlEPTB;MkWuN|MyPiEQvF2= MXjTRW5ITVJ?
LNCaP-Clone-FGC M2P2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTZTWM2OD1{NT6zOFk5KM7:TR?= MWnTRW5ITVJ?
PA-1 NUK1V|ZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXjbllKSzVyPUK1MlY5OzNizszN Mk\tV2FPT0WU
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HT-29 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37TSGlEPTB;MkWuO|g4QSEQvF2= M1PZdXNCVkeHUh?=
RCM-1 NYLHfGlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XLOGlEPTB;MkWuPVY2PiEQvF2= M3z2WXNCVkeHUh?=
NCI-H1522 MojYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjhU2hnUUN3ME2yOU46QTFzIN88US=> NULNNGdOW0GQR1XS
LB373-MEL-D M2DYRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\XTWxKSzVyPUK2MlE4ODhizszN Mm\WV2FPT0WU
NCI-H1436 MnLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTJ4LkK3N|gh|ryP MVvTRW5ITVJ?
COLO-824 NXW4ZXJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTJ4LkSwNFIh|ryP MXLTRW5ITVJ?
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EGI-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jQSmlEPTB;MkeuNlY6QCEQvF2= MVXTRW5ITVJ?
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JVM-2 M3H6cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPUN2lCUUN3ME2yO{43PjJ{IN88US=> MkTmV2FPT0WU
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SW1783 NV7NcZVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LBcGlEPTB;MkeuO|c5OyEQvF2= Mki4V2FPT0WU
HT-3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrFfJFXUUN3ME2yPE4zOTZ4IN88US=> NVXqeZU5W0GQR1XS
RL MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrkXoE6UUN3ME2yPE42QTFzIN88US=> MnW0V2FPT0WU
TK10 M4PpcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3e2RmlEPTB;MkiuOlU{PSEQvF2= MUHTRW5ITVJ?
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GT3TKB M3\LVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTJ7Lk[4O|ch|ryP M2T5ZnNCVkeHUh?=
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NCI-H661 Mo\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWm0[lZ1UUN3ME2zNk43PTBzIN88US=> M1jQTnNCVkeHUh?=
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MDA-MB-453 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrSTmViUUN3ME2zOU4yPDJ4IN88US=> MmTlV2FPT0WU
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NCI-H1395 NH\GNlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkWyTWM2OD1|NT62OlkyKM7:TR?= MUXTRW5ITVJ?
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HCC2998 NYLnc3luT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MortTWM2OD1|Nj64OVcyKM7:TR?= NH6zSXVUSU6JRWK=
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UMC-11 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PobmlEPTB;M{euNlUxOyEQvF2= M2\Nc3NCVkeHUh?=
THP-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{ezdGlEPTB;M{euNlg3QCEQvF2= NGPHT4NUSU6JRWK=
OCUB-M NXXHdoNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFH0S|lKSzVyPUO3MlI5QTFizszN NHO5[IpUSU6JRWK=
NCI-H1693 NWT2eFZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnyS2ZsUUN3ME2zO{4{OjN|IN88US=> NVr3UllwW0GQR1XS
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NCI-H596 NHztfnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M16wUmlEPTB;M{iuOFQ5QSEQvF2= M32wdXNCVkeHUh?=
NCI-H187 NGnLdHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnuTWM2OD1|OD63N|Q1KM7:TR?= NVftfYdZW0GQR1XS
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KP-4 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vqWmlEPTB;M{muNVI{PSEQvF2= NWDsOpU3W0GQR1XS
NCI-H2227 NELIRlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTN7LkO5OFkh|ryP M33OfHNCVkeHUh?=
22RV1 NFnsUFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXmU5NsUUN3ME2zPU45Ozl6IN88US=> MX3TRW5ITVJ?
SAS M{PIc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTRyLkC5OkDPxE1? NG\kN45USU6JRWK=
PANC-10-05 Mmm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGqzdGxKSzVyPUSwMlE5OjhizszN NHPGdXZUSU6JRWK=
MDA-MB-468 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPrTWM2OD12MD61N|Q3KM7:TR?= NYO2epV4W0GQR1XS
RPMI-7951 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DxcmlEPTB;NEGuNlA4PSEQvF2= MmDoV2FPT0WU
BB49-HNC Mnq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jVVmlEPTB;NEGuNlE4QSEQvF2= NUL3R3ZTW0GQR1XS
23132-87 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTRzLkK3N|Ih|ryP MUjTRW5ITVJ?
HCC1569 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrhTWM2OD12MT6yPFg2KM7:TR?= M{fpOXNCVkeHUh?=
CP66-MEL NXLQZXZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTR{LkG4PFYh|ryP M4q3W3NCVkeHUh?=
K-562 NVe4U|VyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3OTWM2OD12Mj6yPFU1KM7:TR?= NEWzZWVUSU6JRWK=
OCI-AML2 M2fwcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3H4cWlEPTB;NEKuPFk4PCEQvF2= MorhV2FPT0WU
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NCI-H1623 MmLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nuN2lEPTB;NEOuOFY1KM7:TR?= NV2y[mp{W0GQR1XS
KNS-81-FD M324Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjGTWM2OD12Mz63OlIh|ryP NFPGV2ZUSU6JRWK=
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RERF-LC-MS NVfpcGdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXtTWM2OD12Mz65NlgyKM7:TR?= NWT6elFDW0GQR1XS
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NCI-H510A NUXSSldiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnntTWM2OD12ND63NFgh|ryP Mke0V2FPT0WU
LB2518-MEL NFK0bIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXroPIlJUUN3ME20OE44QTN5IN88US=> M{HLc3NCVkeHUh?=
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NCI-H524 M2fzS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTR4LkexPFUh|ryP MXTTRW5ITVJ?
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KALS-1 M4LhOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXTTWM2OD12Nz6yNFY3KM7:TR?= M{fITHNCVkeHUh?=
BT-474 M2n3eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;lUYNKSzVyPUS3MlQzOTZizszN M4CwSXNCVkeHUh?=
SK-N-AS MlrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XTZ2lEPTB;NEeuPFg5KM7:TR?= MVPTRW5ITVJ?
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S-117 M1XnU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVj5TpBzUUN3ME20PE4{QDF3IN88US=> NVHXVIp7W0GQR1XS
LS-1034 NH7JSGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TGcGlEPTB;NEiuO|A3PyEQvF2= NEjxTXZUSU6JRWK=
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LU-134-A M3fpN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIiySZhKSzVyPUS5MlgxQDVizszN MV;TRW5ITVJ?
NCI-H1838 MoLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3Se2hKSzVyPUS5MlgxQDdizszN M3;YdXNCVkeHUh?=

... Click to View More Cell Line Experimental Data
体内研究 Ponatinib抑制取自FLT3-ITD阳性AML病人的原代白血病细胞，而不抑制表达阴性FLT3的AML病人的白血病细胞。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验：[1]
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激酶实验:

通过同质时间分辨荧光共振能量转移法(TR-FRET)，使用纯化的人类野生型ABL激酶，T315I突变型ABL激酶，及生物素化的磷酸激酶底物肽: 生物素-EKKMAAEAIYAAPFAK-NH2，测定野生型ABL和T315I突变型ABL活性的抑制激酶反应在全LANCE激酶buffer (LKB)中进行，LKB包括20 mM NaHEPES（pH 为7.4）, 0.1 mg ⁄ mL BSA, 1 mM ATP, 10 mM MgCl2, 及0.41 mM DTT，在提前用1% BSA（溶于PBS）包被的96孔板上4oC下过夜。用于激酶反应，Ponatinib稀释物和野生型ABL, T315I突变型ABL (40 pM), 及底物肽(50 nM), 在室温下温育1小时（T315I突变型ABL）或2小时（野生型ABL）。加入15 nM 抑制剂, 6 nM 铕标记的磷酸酪氨酸抗体（磷酸化位点在第66为酪氨酸上），及60 nM 别藻蓝素标记的链酶亲和素，终止反应。实验板在室温下黑暗温育20分钟，使用Wallac Victor2V读数器读取615和665nm处的荧光值。在孔中数据平均值中插入抑制剂的3倍连续稀释液，再读取665nm处荧光值，计算IC50值。
细胞实验：[1]
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  • Cell lines: Ba ⁄ F3细胞
  • Concentrations: 0-625 nM, 和0-10 µM
  • Incubation Time: 72小时
  • Method: Ba/F3细胞系按每孔4×103个细胞分布在96孔板上(4×103)，和梯度浓度Ponatinib温育72小时。Ponatinib浓度范围为: 0-625 nM 作用于表达BCR-ABL细胞，0-10 µM 用于测定BCR-ABL阴性细胞。使用MTS实验测定细胞增殖，取三次平行实验平均值测定IC50值。
    (Only for Reference)
动物实验：[3]
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  • Animal Models: 皮下植入MV4-11细胞移植瘤(1×107，50%基质胶中) 的雌性CB.17 SCID鼠
  • Formulation: 25 mmol/L柠檬酸盐缓冲液(pH 为2.75)
  • Dosages: 每天处理一次，持续4周
  • Administration: 口服饲喂处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)：
1% CMC Na 		30mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 532.56
化学式

C29H27F3N6O
CAS号 943319-70-8
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量：

总分子量：g/mol

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03838692 Not yet recruiting Medullary Thyroid Cancer Antonio Fojo|Millennium Pharmaceuticals Inc.|Columbia University April 2019 Phase 2
NCT03838692 Not yet recruiting Medullary Thyroid Cancer Antonio Fojo|Millennium Pharmaceuticals Inc.|Columbia University April 2019 Phase 2
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03807479 Recruiting Leukemia Myeloid Chronic-Phase GWT-TUD GmbH|Incyte Biosciences International Sàrl December 11 2018 Phase 2
NCT03807479 Recruiting Leukemia Myeloid Chronic-Phase GWT-TUD GmbH|Incyte Biosciences International Sàrl December 11 2018 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1：

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答：

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

Selleck产品目录册

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

  • 选择性强的Bcr-Abl抑制剂

    Nilotinib (AMN-107) : Bcr-Abl-selective, IC50<30 nM.

  • 活性最高的Bcr-Abl抑制剂

    GZD824 : Bcr-Abl(WT), IC50=0.34 nM; Bcr-Abl(T315I), IC50=0.68 nM.

  • FDA批准的Bcr-Abl抑制剂

    Dasatinib : Approved by FDA for CML and Ph+ ALL.

  • 最新的Bcr-Abl抑制剂

    GZD824 : Orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

相关Bcr-Abl产品

  • PX-478 2HCl New

    PX-478 2HCl是一种具有口服活性的选择性hypoxia-inducible factor-1α (HIF-1α)抑制剂。Phase 1。

  • Defactinib (VS-6063, PF-04554878) New

    Defactinib (VS-6063, PF-04554878)是一种选择性，且口服有效的FAK抑制剂。Phase 2。

  • SU6656 New

    SU 6656 是一种选择性 Src 家族激酶抑制剂，对Src，Yes，Lyn，和 Fyn 的 IC50 分别为 280 nM，20 nM，130 nM，和 170 nM。

  • Imatinib Mesylate (STI571)

    Imatinib Mesylate (STI571)是一种口服生物有效的Imatinib甲磺酸盐，是一种多靶点抑制剂，作用于v-Abl，c-Kit和PDGFR，在无细胞和细胞试验中，IC50分别为0.6 μM，0.1 μM 和0.1 μM。

  • Nilotinib (AMN-107)

    Nilotinib (AMN-107)是一种特异性BCR-ABL抑制剂，在小鼠骨髓祖细胞中IC50低于30 nM。

    Features:Nilotinib 是Abl选择性抑制剂，与BCR-ABL的ATP结合位点相互作用。

  • Bafetinib (INNO-406)

    Bafetinib (INNO-406)是一种有效的，选择性的，双重Bcr-Abl/Lyn双重抑制剂，无细胞试验中IC50为5.8 nM/19 nM，对T315I突变型的磷酸化没有抑制作用，对PDGFR和c-Kit的作用效果较弱。Phase 2。

    Features:Bafetinib是有效的双重Bcr-Abl/Lyn酪氨酸激酶选择性抑制剂。

  • Degrasyn (WP1130)

    Degrasyn (WP1130)是一种选择性deubiquitinase (DUB: USP5，UCH-L1，USP9x，USP14，和 UCH37)抑制剂，对Bcr/Abl也有抑制作用，也是一种JAK2传感器(不影响20S蛋白酶体)和转录激活剂(STAT)。

    Features:WP1130 has an advantage over imatinib mesylate in that its activity is not inhibited by a variety of Abl kinase mutations, including T315I.

  • Rebastinib (DCC-2036)

    Rebastinib (DCC-2036)是一种Bcr-Abl抑制剂，作用于Abl1(WT)和Abl1(T315I)，IC50分别为0.8 nM和4 nM，也抑制SRC， LYN， FGR， HCK， KDR， FLT3，和Tie-2，对c-Kit具有低的抑制活性。Phase 1。

  • GZD824 Dimesylate(HQP1351)

    GZD824 Dimesylate是新型口服有效的Bcr-Abl抑制剂，作用于Bcr-Abl(WT)和Bcr-Abl(T315I)，IC50分别为0.34 nM和0.68 nM。

  • GNF-2

    GNF-2是一种高选择性，非ATP竞争性的Bcr-Abl抑制剂，对Flt3-ITD， Tel-PDGFR， TPR-MET和Tel-JAK1转化的肿瘤细胞没有作用活性。

Tags: 购买Ponatinib (AP24534) | Ponatinib (AP24534)供应商 | 采购Ponatinib (AP24534) | Ponatinib (AP24534)价格 | Ponatinib (AP24534)生产 | 订购Ponatinib (AP24534) | Ponatinib (AP24534)代理商
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID