Ponatinib (AP24534)

目录号:S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534)是一种新型有效的多靶点抑制剂,在无细胞试验中作用于Abl,PDGFRα,VEGFR2,FGFR1和Src,IC50分别为0.37 nM,1.1 nM,1.5 nM,2.2 nM和5.4 nM。

规格 价格 库存 购买数量  
In DMSO RMB 819.31 现货
RMB 903.01 现货
RMB 3034.48 现货
RMB 7959.08 现货
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产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

产品描述 Ponatinib (AP24534)是一种新型有效的多靶点抑制剂,在无细胞试验中作用于Abl,PDGFRα,VEGFR2,FGFR1和Src,IC50分别为0.37 nM,1.1 nM,1.5 nM,2.2 nM和5.4 nM。
靶点
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外研究

Ponatinib是有效的可用于口服的多靶点激酶抑制剂,作用于野生型细胞,及T315I 突变细胞IC50分别为1.2和8.8nM。[1] Ponatinib抑制Ba/F3衍生细胞系的增殖。[2] Ponatinib作用于表达野生型或T315I突变型BCR-ABL的CML细胞系,有效抑制BCR-ABL调节的信号。Ponatinib阻断在细胞瘤筛选时产生抗性突变。[3] Ponatinib也抑制VEGFR和FGFR家族激酶,在体外抑制FLT3, KIT, FGFR1,和PDGFRa激酶活性时IC50分别为13, 13, 2, 和1 nM.[4]Ponatinib抑制全部4种RTKs磷酸化,存在剂量依赖性,IC50值为0.3到20 nM。然而,Ponatinib抑制表达野生型FLT3的RS4;11细胞时IC50>100 nM。

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NH\MSIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMECwNFAxODN3OTFOwG0> MUjTRW5ITVJ?
MV-4-11 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLnTWM2OD1yLkCwNFA6PTZizszN MmT0V2FPT0WU
MEG-01 NX;NcHgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUe0WnZJUUN3ME2wMlAxODF{ODFOwG0> NGXXRppUSU6JRWK=
LAMA-84 MkLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XScGlEPTB;MD6wNFAyPjVizszN M{LzT3NCVkeHUh?=
CGTH-W-1 MlLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVH0b3hGUUN3ME2wMlAxOTZ7IN88US=> MlXGV2FPT0WU
KASUMI-1 M1vlSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37zUGlEPTB;MD6wNFIyPyEQvF2= NWDPcmRPW0GQR1XS
BE-13 NV\t[GtxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMECyOVkh|ryP MknUV2FPT0WU
CTV-1 NHPQSlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jFcWlEPTB;MD6wNFUzOSEQvF2= Mke4V2FPT0WU
NKM-1 MorJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorITWM2OD1yLkCwOlU2KM7:TR?= M4rRbHNCVkeHUh?=
MONO-MAC-6 MlzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETKZXNKSzVyPUCuNFA5OzdizszN NE\DelBUSU6JRWK=
A204 M4XzSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4q5ZmlEPTB;MD6wNVIyQCEQvF2= M1zzPXNCVkeHUh?=
GDM-1 M3TNWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwMEG4N|Mh|ryP MYfTRW5ITVJ?
AN3-CA NXnJVFdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3VS2dYUUN3ME2wMlAyQDd|IN88US=> MVjTRW5ITVJ?
BL-70 NED1d|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2f3UmlEPTB;MD6wNlE6QSEQvF2= NFnOcmlUSU6JRWK=
Daudi Mke4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnznTWM2OD1yLkCyOVM4KM7:TR?= NWfvOZFDW0GQR1XS
KU812 NGjKNIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDYTWM2OD1yLkCyPFQ5KM7:TR?= MWDTRW5ITVJ?
KG-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMEOyPVQh|ryP MoPPV2FPT0WU
DOHH-2 MlXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37aOmlEPTB;MD6wOFgxOyEQvF2= NVH3b4dsW0GQR1XS
HuO9 NXjWXWd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVe3bm5vUUN3ME2wMlA2PDR6IN88US=> MWjTRW5ITVJ?
EB2 NHLpZ5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIn5O3BKSzVyPUCuNFU2PzZizszN M1nvPXNCVkeHUh?=
G-402 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV74RmVXUUN3ME2wMlA3OzRzIN88US=> M2LSfHNCVkeHUh?=
SU-DHL-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYK4O|RwUUN3ME2wMlA3Ozd7IN88US=> MYXTRW5ITVJ?
NCI-H719 NIexXmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUWxeVVNUUN3ME2wMlA4QDh6IN88US=> NV64d4RQW0GQR1XS
MLMA M4Xlbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHjNZNKSzVyPUCuNFkxPiEQvF2= MoPJV2FPT0WU
KM12 M4Hpdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMEm3N|ch|ryP MX7TRW5ITVJ?
SUP-T1 NVH5UIt7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWq5PJFtUUN3ME2wMlA6QTh{IN88US=> MonZV2FPT0WU
MZ1-PC M2T4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnER3VuUUN3ME2wMlEyOzN4IN88US=> NGThNo1USU6JRWK=
MFE-296 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMUG4N|kh|ryP Ml\VV2FPT0WU
ALL-PO NYnqNZJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7oTWM2OD1yLkGyOFQ{KM7:TR?= M{\HU3NCVkeHUh?=
GB-1 MljSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXnWVRKSzVyPUCuNVI2OTJizszN NEf0R2JUSU6JRWK=
SIG-M5 MoqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMUOzO{DPxE1? NFvobmVUSU6JRWK=
P30-OHK NEjRc3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfQPHZOUUN3ME2wMlE2Pjd{IN88US=> MV;TRW5ITVJ?
NCI-H716 NX7IeGJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMU[yOlYh|ryP NWP0fGRtW0GQR1XS
MPP-89 M4PETWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33BeGlEPTB;MD6xOlk{OyEQvF2= M4qyeHNCVkeHUh?=
SF126 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LuR2lEPTB;MD6xO|A3OyEQvF2= M3;lOnNCVkeHUh?=
CTB-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojaTWM2OD1yLkG3N|E3KM7:TR?= MnjZV2FPT0WU
CA46 NGfv[YNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Hu[WlEPTB;MD6xO|Q5QSEQvF2= NFrDOYZUSU6JRWK=
NCI-H520 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHyTWM2OD1yLkG3O|MzKM7:TR?= MmfRV2FPT0WU
CAL-85-1 NGO3T3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfEcYlFUUN3ME2wMlE4QTJ5IN88US=> NYm0boduW0GQR1XS
NCI-H2342 MlryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFGxcJNKSzVyPUCuNVg2PzdizszN NXjDWGM{W0GQR1XS
697 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMUi4O|Eh|ryP NUPMTGZLW0GQR1XS
NY MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfVS3NWUUN3ME2wMlE6Ojh5IN88US=> NHnVeJZUSU6JRWK=
T98G MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTxRmdSUUN3ME2wMlE6OzF6IN88US=> M3\UZ3NCVkeHUh?=
NCI-H1703 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIntZmZKSzVyPUCuNVk3OTVizszN Mne0V2FPT0WU
NCI-H2087 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlryTWM2OD1yLkKwOFM6KM7:TR?= MmW2V2FPT0WU
PF-382 MnG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMkC4O|Mh|ryP MUTTRW5ITVJ?
HCT-116 M2X0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mon4TWM2OD1yLkKxNFY6KM7:TR?= NX3Nbnp5W0GQR1XS
CAKI-1 MmXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoC1TWM2OD1yLkKxOlY3KM7:TR?= M{GxV3NCVkeHUh?=
CCF-STTG1 M3XRb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\LTWM2OD1yLkKyOFc2KM7:TR?= MkXYV2FPT0WU
D-392MG NVfN[JVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF:yUnJKSzVyPUCuNlMyPzdizszN NVXFeFRPW0GQR1XS
RT-112 NWK1O4NET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkD5TWM2OD1yLkKzO|k2KM7:TR?= NW\pe3NEW0GQR1XS
MES-SA M{DreWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTLOGRKSzVyPUCuNlQyQDdizszN NX3PWnd6W0GQR1XS
LC-2-ad M2ruNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzvW|hFUUN3ME2wMlI1OjZ3IN88US=> NELm[25USU6JRWK=
NOS-1 MnniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDNVVZyUUN3ME2wMlI1OzZ5IN88US=> M{DPc3NCVkeHUh?=
NALM-6 M3P3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEno[ItKSzVyPUCuNlU2PDNizszN MXLTRW5ITVJ?
TE-15 NHPvd4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37hXmlEPTB;MD6yOlA6OSEQvF2= MXfTRW5ITVJ?
786-0 NGHBSHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\HW5lDUUN3ME2wMlI3OjJ6IN88US=> M{i0b3NCVkeHUh?=
IST-MES1 M1:wRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3NTWM2OD1yLkK2PFI6KM7:TR?= M1PaRnNCVkeHUh?=
KYSE-180 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMk[4PVEh|ryP NHrXfGdUSU6JRWK=
YT M1HzbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;scmlEPTB;MD6yOlk4PCEQvF2= M3;RVnNCVkeHUh?=
A427 MlzOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TwUWlEPTB;MD6yO|I3PCEQvF2= NXztR4pOW0GQR1XS
KYSE-450 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\sTWM2OD1yLkK3N|I6KM7:TR?= MUfTRW5ITVJ?
HuH-7 MojQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPvTWM2OD1yLkK3O|Y{KM7:TR?= MYLTRW5ITVJ?
CAS-1 NX7uWlBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnflTWM2OD1yLkK4N|A{KM7:TR?= MnrmV2FPT0WU
KURAMOCHI NVTzVnRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnVTWM2OD1yLkK4OFE6KM7:TR?= MkX5V2FPT0WU
ACHN MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLMTWM2OD1yLkK5N|I{KM7:TR?= M{HVenNCVkeHUh?=
HGC-27 Mor1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTJTWM2OD1yLkK5N|U{KM7:TR?= NIDaeJVUSU6JRWK=
A172 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEKxd2ZKSzVyPUCuNlk2PzdizszN MmD3V2FPT0WU
SNU-449 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPOcmZXUUN3ME2wMlI6QTZ2IN88US=> MoDXV2FPT0WU
SW982 NH:2ZohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnwOlVCUUN3ME2wMlI6QTd6IN88US=> MVvTRW5ITVJ?
EFO-21 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nYSWlEPTB;MD6zNFQyOSEQvF2= NX\6b3Z4W0GQR1XS
NCI-H2030 NHm0fYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwM{GxOlQh|ryP NUPPfnZVW0GQR1XS
HT-144 NVznO5lnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXizUnJXUUN3ME2wMlMyOjhizszN M3PuSnNCVkeHUh?=
MFE-280 MnW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXteXZ4UUN3ME2wMlMyPDV|IN88US=> NVz1[2x6W0GQR1XS
SK-LU-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzhTWM2OD1yLkOxOFY3KM7:TR?= MVPTRW5ITVJ?
NCI-H2052 NEHuVYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoD2TWM2OD1yLkOxOFg1KM7:TR?= NHi1SGhUSU6JRWK=
SK-HEP-1 NIfO[lBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHwbVVIUUN3ME2wMlM{OzZ6IN88US=> NXvhZWpOW0GQR1XS
QIMR-WIL NITpdJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjHPYxKSzVyPUCuN|M1OjRizszN NXfifYt2W0GQR1XS
A2780 NVGwcINHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;OTWM2OD1yLkO0N|A1KM7:TR?= NGe4bllUSU6JRWK=
ACN MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzTTWM2OD1yLkO0PFc{KM7:TR?= MVjTRW5ITVJ?
BxPC-3 NXizW5J{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwM{S5PFkh|ryP M37qd3NCVkeHUh?=
BCPAP MoL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHITWM2OD1yLkO2NFAyKM7:TR?= MXXTRW5ITVJ?
HOP-62 NF7sPI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzFVndKSzVyPUCuN|YyODZizszN M3Lme3NCVkeHUh?=
SW1710 MmK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLyUo1GUUN3ME2wMlM3PDV3IN88US=> NIL6OJJUSU6JRWK=
OPM-2 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwM{[0O|Mh|ryP M4\WenNCVkeHUh?=
DBTRG-05MG MmDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nS[2lEPTB;MD6zPFA2PCEQvF2= NVLL[HN4W0GQR1XS
SK-MEL-24 M1L4WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwM{m3PVEh|ryP NYXVWIFuW0GQR1XS
8305C MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfyTWM2OD1yLkO5O|k{KM7:TR?= MnXSV2FPT0WU
OVCAR-4 M{f5[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwNEG1PFYh|ryP NX;vXIk4W0GQR1XS
HLE NVHGR2xiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwNEG4OkDPxE1? NYjqXJdlW0GQR1XS
NCI-H747 MnLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwNEKxN|ch|ryP MkezV2FPT0WU
SW780 MoTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwNEKzOFYh|ryP NWjlNYpqW0GQR1XS
KYSE-150 Mn7IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHTXIQxUUN3ME2wMlQzPDF3IN88US=> MYLTRW5ITVJ?
H4 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfIbINKSzVyPUCuOFI1PTFizszN MWnTRW5ITVJ?
SW1088 NWj0OHJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3iyW2lEPTB;MD60OFM6KM7:TR?= NGHxfmxUSU6JRWK=
SF268 MofGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;O[|U{UUN3ME2wMlQ1QDZizszN MULTRW5ITVJ?
RT4 NUT1PFd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzuWItVUUN3ME2wMlQ2OTFzIN88US=> M4LWUHNCVkeHUh?=
NCI-H522 MnvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XpfGlEPTB;MD60OVI4KM7:TR?= NFTwS45USU6JRWK=
LCLC-97TM1 M3jse2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7WdolKUUN3ME2wMlQ3OTl3IN88US=> Mk[yV2FPT0WU
CAL-39 MlTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwNE[1NVkh|ryP MoH6V2FPT0WU
CAL-120 M4nYV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwNEe2OFMh|ryP Mk\IV2FPT0WU
ESS-1 NWXaeVFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jxSWlEPTB;MD60O|gzOSEQvF2= MY\TRW5ITVJ?
KARPAS-45 NEH5cmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwNEi5N|Mh|ryP MXzTRW5ITVJ?
DU-4475 MmnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwNEm1NVEh|ryP NGnLUZNUSU6JRWK=
VMRC-RCZ NXzWVlY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHSTWM2OD1yLkS5PVA1KM7:TR?= MXLTRW5ITVJ?
HOS MonPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwNUCzOlUh|ryP MVnTRW5ITVJ?
MOLT-16 NH7R[oZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwNUG4NFgh|ryP M2DucXNCVkeHUh?=
RPMI-6666 NYXqfIRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nPcmlEPTB;MD61NlE{PSEQvF2= MX3TRW5ITVJ?
K052 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzYTWM2OD1yLkWyNVQh|ryP NX7SfZl1W0GQR1XS
EHEB MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPKe2FUUUN3ME2wMlUzOTh{IN88US=> NWjzVlZOW0GQR1XS
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L-428 NUS1e|ZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkS2TWM2OD1zLkm5NVc6KM7:TR?= MVPTRW5ITVJ?
KM-H2 NUL3S25HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTJwMEGwPUDPxE1? NWDtO|JRW0GQR1XS
MC-IXC MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTJwMEKyO|Mh|ryP MXrTRW5ITVJ?
COLO-678 M2fBWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHRNpZKSzVyPUKuNFQzODdizszN NVPOcHhiW0GQR1XS
MEL-JUSO M4\Jc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2T4NWlEPTB;Mj6wO|g2OSEQvF2= MWnTRW5ITVJ?
HCC38 M4nkOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fndGlEPTB;Mj6wPFQ{OyEQvF2= MnzMV2FPT0WU
UACC-62 NXLFNmZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnUTWM2OD1{LkC4PFU2KM7:TR?= MlrWV2FPT0WU
OAW-42 MnLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\WTWM2OD1{LkC5O|EyKM7:TR?= M1f5fnNCVkeHUh?=
LB996-RCC MkC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\wOVRHUUN3ME2yMlE{QDF5IN88US=> MUjTRW5ITVJ?
COR-L105 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fRO2lEPTB;Mj6xOlM4OyEQvF2= NYX2ZllOW0GQR1XS
RCC10RGB M4LidGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJwMUi1O|Yh|ryP MVXTRW5ITVJ?
A431 NIf2WWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELCdGhKSzVyPUKuNVkxOTlizszN MVPTRW5ITVJ?
NCI-H292 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3n3PGlEPTB;Mj6yN|k2OSEQvF2= MU\TRW5ITVJ?
SK-UT-1 M1LabGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPwTWM2OD1{LkOzNVg1KM7:TR?= M2izWnNCVkeHUh?=
PANC-08-13 M{LYdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTJwM{OyN|Uh|ryP MVjTRW5ITVJ?
ST486 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYm0U4xOUUN3ME2yMlQyODR6IN88US=> NUXafVh3W0GQR1XS
SJSA-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\BSY8{UUN3ME2yMlQyOjdzIN88US=> M3ztNHNCVkeHUh?=
RKO MmD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17EV2lEPTB;Mj60NlAzQSEQvF2= NYHFSYJuW0GQR1XS
NCI-H1793 M{D0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX23T4ZTUUN3ME2yMlQ1ODJ7IN88US=> MX7TRW5ITVJ?
639-V MlLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;ISndLUUN3ME2yMlQ2Ozh{IN88US=> NUHSbIZrW0GQR1XS
ES3 NIq2fIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnMenZ2UUN3ME2yMlQ6PzN5IN88US=> NXTw[20yW0GQR1XS
NCI-H1792 MlTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnlNYVPUUN3ME2yMlU3QDJ4IN88US=> NU\FfWJ5W0GQR1XS
NCI-H1651 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zxV2lEPTB;Mj61PFIyKM7:TR?= MVLTRW5ITVJ?
SN12C NIPL[lNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7VTWM2OD1{LkW4OFg4KM7:TR?= MmnSV2FPT0WU
COLO-679 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPTTWM2OD1{LkW4OlA2KM7:TR?= MVTTRW5ITVJ?
U-118-MG NX;RNFd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHieJRKSzVyPUKuOVg5PzJizszN NUjtVVROW0GQR1XS
Ramos-2G6-4C10 NFfWfVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\qXmlEPTB;Mj62OFgxPyEQvF2= NHLURVBUSU6JRWK=
HCT-15 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTJwNki3PVIh|ryP M4TsNXNCVkeHUh?=
MDA-MB-157 MmrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrYb29CUUN3ME2yMlcxPzR5IN88US=> MkLlV2FPT0WU
K5 NWHHOHhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFn4fHFKSzVyPUKuO|E5PDVizszN NHHTUZpUSU6JRWK=
MKN45 M3vKbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;wTWM2OD1{LkezN|Y3KM7:TR?= NFzsU5BUSU6JRWK=
DMS-273 M4XiUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzGSlBKSzVyPUKuO|U3OzJizszN NFnM[pFUSU6JRWK=
C8166 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTkTWM2OD1{Lke4OVE{KM7:TR?= NYPUOmpJW0GQR1XS
Calu-3 NIHxZ4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PWdmlEPTB;Mj63PFk3QSEQvF2= MUfTRW5ITVJ?
SNB75 NEfzb2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTJwOEi1N|Uh|ryP NHrXToVUSU6JRWK=
BFTC-905 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7LUm5KSzVyPUKuPVAyQTFizszN M1GyO3NCVkeHUh?=
C-4-II NUKwNWF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWW2O|I1UUN3ME2yMlkyOzV|IN88US=> M2HKcnNCVkeHUh?=
MS-1 M2jNdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTJwOU[3Olkh|ryP M4iyVXNCVkeHUh?=
A375 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1i2TWlEPTB;Mz6wPFE5PCEQvF2= Mlz3V2FPT0WU
KYSE-70 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTNwMEi4PFIh|ryP M4\yXnNCVkeHUh?=
KYSE-510 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPHZ4d6UUN3ME2zMlExQTl3IN88US=> MYXTRW5ITVJ?
LN-405 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnz[o9kUUN3ME2zMlE{PTF6IN88US=> NFHWZpJUSU6JRWK=
BOKU M4fM[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTNwMUSyOVYh|ryP MmDzV2FPT0WU
TE-10 Mn7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjIRWpKSzVyPUOuNVc{PjJizszN NG[1SIFUSU6JRWK=
MKN1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPBc3FKSzVyPUOuNVg1QDNizszN NYf4W2VLW0GQR1XS
M059J NVKwT3c5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2m1bmlEPTB;Mz6yNFE4OyEQvF2= NHvSZ4pUSU6JRWK=
GOTO M1jrS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTYZYhSUUN3ME2zMlIzODN7IN88US=> MkLTV2FPT0WU
DK-MG MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHr2TJNKSzVyPUOuNlU6PzZizszN MVHTRW5ITVJ?
NCI-H727 NVvIT2NlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDPcXIxUUN3ME2zMlI3PThizszN NF3RSXBUSU6JRWK=
NB12 MoDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLLTWM2OD1|LkOzNlI1KM7:TR?= MYDTRW5ITVJ?
DOK NImzSnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTNwM{[xPFYh|ryP NFrjfphUSU6JRWK=
KYSE-410 M2n2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVf0XGIzUUN3ME2zMlM3Ojh5IN88US=> M3f5b3NCVkeHUh?=
AM-38 NYf0e5Z[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfoT2Q3UUN3ME2zMlM5ODVzIN88US=> NVjycHNIW0GQR1XS
GR-ST NHixbFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHUd2lKSzVyPUOuOFU4OzJizszN MVfTRW5ITVJ?
D-247MG M1zGU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjCV4lKSzVyPUOuOFgzPjNizszN M3fMZnNCVkeHUh?=
TE-8 M4\ITGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWSzbXlkUUN3ME2zMlQ6OzN|IN88US=> NUT2RpBIW0GQR1XS
LS-411N NUPBWXVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jLb2lEPTB;Mz60PVY6OiEQvF2= MonjV2FPT0WU
SK-MES-1 Mm\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnMemtKSzVyPUOuOVY1OzNizszN NFvQT5NUSU6JRWK=
SF295 NVvGVGZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3NTWM2OD1|Lk[xOVUzKM7:TR?= NVf3PWhuW0GQR1XS
SK-MEL-30 NG\vZYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITSV4hKSzVyPUOuOlU6OjFizszN MYHTRW5ITVJ?
LB2241-RCC M1nlTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33remlEPTB;Mz62OlI3KM7:TR?= MU\TRW5ITVJ?
PC-14 M1n0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVft[|RyUUN3ME2zMlY3PDN5IN88US=> NEHycopUSU6JRWK=
EW-7 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTNwNke2PVMh|ryP M4riSHNCVkeHUh?=
NMC-G1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\aPYhKSzVyPUOuO|E5OzdizszN M3i0dHNCVkeHUh?=
TE-441-T MofPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfJPVRKSzVyPUOuO|MxOjhizszN NWfwWHVrW0GQR1XS
NCI-H1618 MmTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjNXVV[UUN3ME2zMlgyQDd3IN88US=> M{\abHNCVkeHUh?=
PANC-03-27 M{fXPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLpTWM2OD1|LkixPVE3KM7:TR?= NHT5eYpUSU6JRWK=
NCI-H2228 NHW2[ndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nvSGlEPTB;Mz64N|EzPiEQvF2= MV\TRW5ITVJ?
CAPAN-1 MmfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHFb|BKSzVyPUOuPFcxODlizszN M{HyWHNCVkeHUh?=
KLE MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLXTWM2OD1|LkmwOlch|ryP M4DDcHNCVkeHUh?=
Becker MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\mToFkUUN3ME2zMlkzQDR7IN88US=> M1LwfHNCVkeHUh?=
SK-PN-DW NU\ofYo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PwdWlEPTB;ND6wO|k4PCEQvF2= NH;4XphUSU6JRWK=
Hs-578-T NVHwNYpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPYTWM2OD12LkC4N|A3KM7:TR?= M3rxcnNCVkeHUh?=
RS4-11 MlLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTRwMUGyOVUh|ryP MWnTRW5ITVJ?
D-502MG MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\OTWM2OD12LkG2PVk4KM7:TR?= MWDTRW5ITVJ?
GI-1 MnX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLiTWM2OD12LkK4Nlk6KM7:TR?= MX3TRW5ITVJ?
NCI-H209 MnHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M36xTGlEPTB;ND6zN|c5KM7:TR?= NEHiNIpUSU6JRWK=
SK-OV-3 M4XUOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIP2ZXVKSzVyPUSuOFgyPDlizszN MkW4V2FPT0WU
LOUCY NXLuc3pUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPXW|BqUUN3ME20MlQ5PDN{IN88US=> MXvTRW5ITVJ?
NCI-H69 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LnWmlEPTB;ND61NVc6OyEQvF2= NHK5V5FUSU6JRWK=
SCC-9 NInEc21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHkTWM2OD12LkWzNVczKM7:TR?= MnvBV2FPT0WU
NCI-H526 NELSWohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DkZWlEPTB;ND61PVI6OyEQvF2= MVzTRW5ITVJ?
NCI-H2170 MojOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{foXWlEPTB;ND62Olc4OSEQvF2= MXnTRW5ITVJ?
SR NVfGeVF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTRwN{CwOFgh|ryP NU\VbYhqW0GQR1XS
CMK M1XKNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfWTWM2OD12LkeyNVAyKM7:TR?= MV\TRW5ITVJ?
COLO-829 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7BTWM2OD12Lke3NFQ{KM7:TR?= MXvTRW5ITVJ?
HuO-3N1 NF23eGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTRwOEOyPFEh|ryP MkjYV2FPT0WU
5637 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\0O4ZGUUN3ME20MlkxPDh5IN88US=> M3TyWXNCVkeHUh?=
A253 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrS[IhKSzVyPUSuPVc4ODhizszN MUnTRW5ITVJ?
NB10 M2O4e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYH3OI1mUUN3ME21MlA4PDl5IN88US=> MV3TRW5ITVJ?
SF539 NHfHR2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVuySmpTUUN3ME21MlA6QTV7IN88US=> NXzSb29JW0GQR1XS
HAL-01 NXjpTWQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfsTmtiUUN3ME21MlE1PjR3IN88US=> NEPsR|dUSU6JRWK=
MHH-ES-1 M4PGO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTVwMU[5NlUh|ryP M{jGO3NCVkeHUh?=
DEL NFrOe3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PjS2lEPTB;NT6yO|U5OiEQvF2= MYDTRW5ITVJ?
NCI-H1299 NFPkSYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILWOmxKSzVyPUWuN|UxODdizszN NYTqZ49YW0GQR1XS
ChaGo-K-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjVb29mUUN3ME21MlM2OTB5IN88US=> MnH4V2FPT0WU
HMV-II Mn\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXPbWdKSzVyPUWuN|k1OyEQvF2= Mn;wV2FPT0WU
NB69 NUDsb45UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInjOVBKSzVyPUWuN|k3OzFizszN MVvTRW5ITVJ?
NCI-H1882 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofpTWM2OD13LkSzN|Y1KM7:TR?= MX7TRW5ITVJ?
SNU-475 M{DYemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\wR3ZKSzVyPUWuOFcyPzFizszN MorTV2FPT0WU
RXF393 M2D1PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzVTWM2OD13LkS4OFk1KM7:TR?= MkPVV2FPT0WU
CAL-51 Mn;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnhTWM2OD13Lk[yPFU{KM7:TR?= M3TDWnNCVkeHUh?=
SW1573 Mk\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\MTFY{UUN3ME21MlY{PTN2IN88US=> NWPmT4pTW0GQR1XS
GCT NInS[2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTVwN{W5Nlkh|ryP M1nyfXNCVkeHUh?=
COR-L88 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\6NGlEPTB;NT63Olg1PiEQvF2= M3;IW3NCVkeHUh?=
MDA-MB-134-VI Mor5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnubFJKSzVyPUWuPFc2OzZizszN MXzTRW5ITVJ?
NB5 M{\uNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HsOGlEPTB;NT65NlQ1KM7:TR?= MX\TRW5ITVJ?
GMS-10 NUn5XGt6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfpWpVKSzVyPUWuPVY5PjFizszN M2rHdnNCVkeHUh?=
CHP-212 Ml;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIj5[ZNKSzVyPU[uOFgzPjdizszN MX3TRW5ITVJ?
TE-11 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfrTmE6UUN3ME22MlU2OTh{IN88US=> NUTTN4ZVW0GQR1XS
SW962 NGnGO4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LvZ2lEPTB;Nj62OVc4PCEQvF2= NXGydYt4W0GQR1XS
MZ2-MEL NH;DVYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4W5e2lEPTB;Nj64NlAyOSEQvF2= NWHSfYI4W0GQR1XS
C-33-A NHjiSWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrVSW1[UUN3ME22MlkyPjh6IN88US=> MVTTRW5ITVJ?
IGR-1 NGDXfIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfVTWM2OD14Lkm3PFI3KM7:TR?= NHjYbYtUSU6JRWK=
MOLT-4 NH7heYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjCdZJDUUN3ME23MlE2PDB4IN88US=> M1nWXHNCVkeHUh?=
NCI-H1650 NXXZfG9tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;mb|FKSzVyPUeuNlcxPDZizszN M2nhRXNCVkeHUh?=
AsPC-1 MlPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rxd2lEPTB;Nz6yPFYxPSEQvF2= MnS2V2FPT0WU
SNU-C2B NW\IfFh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTdwMkm1O|Eh|ryP NHXQbGJUSU6JRWK=
MKN7 NF3SVm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPETWM2OD15LkO3NlM2KM7:TR?= MlvnV2FPT0WU
SW620 NYjJWllwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjudldKSzVyPUeuN|gzODVizszN MnnxV2FPT0WU
SK-MEL-28 M{nxdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4W1S2lEPTB;Nz60NFc6QCEQvF2= M2Lr[nNCVkeHUh?=
TE-6 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTJN25pUUN3ME23MlQ1QTB6IN88US=> NGj5ZXlUSU6JRWK=
D-263MG MmKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHe3fJFKSzVyPUeuOFU4PjJizszN NW\nPIdWW0GQR1XS
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BB65-RCC NXrsOIF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjRR5ZuUUN3ME2yN{4xOzR2IN88US=> MmP1V2FPT0WU
SiHa NYXYU4FLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLjTWM2OD1{Mz6zPVY5KM7:TR?= NIrJcHVUSU6JRWK=
NCI-H2081 NHP1W5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXTTWM2OD1{ND6wOlQyKM7:TR?= NVTTZoxWW0GQR1XS
U251 NUTO[ldFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHvdWZYUUN3ME2yOE4xPjZ6IN88US=> M1WzdHNCVkeHUh?=
LoVo MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTJ2LkmyPFIh|ryP NFTFb2xUSU6JRWK=
GCIY M4[3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\MZYpKSzVyPUK1MlI5PzdizszN MWfTRW5ITVJ?
NUGC-3 NFTWXpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ezT2lEPTB;MkWuN|MyPiEQvF2= Mn\HV2FPT0WU
LNCaP-Clone-FGC M4TnOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTJ3LkO0PVgh|ryP MmLJV2FPT0WU
PA-1 M{jnfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn64TWM2OD1{NT62PFM{KM7:TR?= NF7mXW5USU6JRWK=
OE33 Mo[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2KwVmlEPTB;MkWuOlg2OyEQvF2= M2L5VXNCVkeHUh?=
HT-29 NXfIS4N4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJ3Lke4O|kh|ryP MW\TRW5ITVJ?
RCM-1 M1HyPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1njeGlEPTB;MkWuPVY2PiEQvF2= MnnwV2FPT0WU
NCI-H1522 NGrLO4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzndpJKSzVyPUK1Mlk6OTFizszN MV\TRW5ITVJ?
LB373-MEL-D MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojuTWM2OD1{Nj6xO|A5KM7:TR?= NWLqNGtFW0GQR1XS
NCI-H1436 NXrOd4pQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETEW4JKSzVyPUK2MlI4OzhizszN NGnkc25USU6JRWK=
COLO-824 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fQNmlEPTB;Mk[uOFAxOiEQvF2= NWnFc4tJW0GQR1XS
CP50-MEL-B MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\tTWM2OD1{Nj61Olc2KM7:TR?= MYHTRW5ITVJ?
EGI-1 NVHJbXc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1z0NmlEPTB;MkeuNlY6QCEQvF2= NG\MVmFUSU6JRWK=
LAN-6 M1zNVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjLTppqUUN3ME2yO{4{PTl6IN88US=> MXjTRW5ITVJ?
GAK NHXJV2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjDTWM2OD1{Nz60NlI2KM7:TR?= NULsbI9uW0GQR1XS
MDA-MB-175-VII NFvUVYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTJ5LkWwOVMh|ryP NF\wToRUSU6JRWK=
JVM-2 NWnhbXFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFq1flZKSzVyPUK3MlY3OjJizszN Mn65V2FPT0WU
UACC-257 NIHFOFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rCdmlEPTB;MkeuOlg4QCEQvF2= MYfTRW5ITVJ?
SW1783 M2XV[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTTVFhKSzVyPUK3Mlc4QDNizszN M3vRWnNCVkeHUh?=
HT-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PMcWlEPTB;MkiuNlE3PiEQvF2= NF;0bodUSU6JRWK=
RL NWXPW4ZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTJ6LkW5NVEh|ryP MYXTRW5ITVJ?
TK10 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTJ6Lk[1N|Uh|ryP NF\XVWlUSU6JRWK=
HT55 MmDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{S3PWlEPTB;MkmuNFU3PSEQvF2= NWftdWdPW0GQR1XS
BT-20 MlLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTCbItKSzVyPUK5MlA2QDZizszN Mn\mV2FPT0WU
TGBC24TKB NHnCWGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvnUXhKSzVyPUK5MlE5OzFizszN M1i0OHNCVkeHUh?=
HSC-2 MmWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3PTWM2OD1{OT6zNFAyKM7:TR?= NFHJNnZUSU6JRWK=
COLO-205 M1LXXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHuyUFZKSzVyPUK5MlM6PDRizszN NHjNZo5USU6JRWK=
GT3TKB MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEj1UGtKSzVyPUK5MlY5PzdizszN MofrV2FPT0WU
T47D MmDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTJ7Lki1PFIh|ryP MVTTRW5ITVJ?
OMC-1 NUXpOGR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXe3UnNMUUN3ME2zNE4yQTF7IN88US=> NFf2[XFUSU6JRWK=
PFSK-1 NF7aPGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfRUJVyUUN3ME2zNU4zPjV7IN88US=> M2rWV3NCVkeHUh?=
JEG-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXjTWM2OD1|MT6zOVYyKM7:TR?= NWTWeYtQW0GQR1XS
RD MonwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvNV5VKSzVyPUOxMlUyOTVizszN NYXVO5cxW0GQR1XS
NCI-H64 NWLYPJlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTBN4RnUUN3ME2zNk41OTd7IN88US=> MnvaV2FPT0WU
DMS-114 M1;0TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHQNG1KSzVyPUOyMlQyQDJizszN NF;Kbm1USU6JRWK=
NCI-H661 MkH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HhOGlEPTB;M{KuOlUxOSEQvF2= NH34NnFUSU6JRWK=
CAL-148 MmXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrTc2ZKSzVyPUOyMlY3PjVizszN M{npZ3NCVkeHUh?=
HuP-T3 MoOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;YTWM2OD1|Mj65N|M5KM7:TR?= MXPTRW5ITVJ?
ES4 MkfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrmPFhlUUN3ME2zN{4yPzB3IN88US=> M{nGT3NCVkeHUh?=
Ca9-22 NUfORXcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTN|LkS2NFEh|ryP NFTWTWNUSU6JRWK=
LP-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XQ[mlEPTB;M{SuNFkh|ryP NInsNmJUSU6JRWK=
AU565 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XKRmlEPTB;M{SuOVA3QSEQvF2= M3zvRnNCVkeHUh?=
MDA-MB-453 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTN3LkG0NlYh|ryP M{nCWHNCVkeHUh?=
SNU-C1 MmHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjvTWM2OD1|NT6xO|Eh|ryP MUXTRW5ITVJ?
SW13 NHTG[nVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2[xOWlEPTB;M{WuOFA4PiEQvF2= NHzCUJpUSU6JRWK=
NCI-H2122 M4rBXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DJTmlEPTB;M{WuOVU6QCEQvF2= MlPLV2FPT0WU
NCI-H1395 M3;BXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknxTWM2OD1|NT62OlkyKM7:TR?= MYLTRW5ITVJ?
J-RT3-T3-5 M2H6Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnu0TWM2OD1|Nj6wNlk1KM7:TR?= NX75cmVPW0GQR1XS
COR-L279 MnTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTN4LkG5PFEh|ryP NWr1SG5qW0GQR1XS
ATN-1 MmDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkD6TWM2OD1|Nj64OVE3KM7:TR?= NGjoPIVUSU6JRWK=
HCC2998 NXXaSJh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\uWnZTUUN3ME2zOk45PTdzIN88US=> MnjQV2FPT0WU
UM-UC-3 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPGTWM2OD1|Nj64Olc2KM7:TR?= NU\X[GhsW0GQR1XS
DV-90 NYP6RpU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTN4LkmwOlch|ryP NXnacmRDW0GQR1XS
ES8 NYjaTJJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnOV2pTUUN3ME2zOk46OzF6IN88US=> MlXjV2FPT0WU
YAPC MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2qyNGlEPTB;M{[uPVY2PCEQvF2= MWTTRW5ITVJ?
HCC1599 NF;l[lhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jZSmlEPTB;M{euNVYyQCEQvF2= NID1R4ZUSU6JRWK=
UMC-11 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1uy[mlEPTB;M{euNlUxOyEQvF2= NYrXenlTW0GQR1XS
THP-1 NGX5V5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTN5LkK4Olgh|ryP MV3TRW5ITVJ?
OCUB-M NI\CVolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYmybY1RUUN3ME2zO{4zQDlzIN88US=> MV7TRW5ITVJ?
NCI-H1693 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmCyTWM2OD1|Nz6zNlM{KM7:TR?= M33GVXNCVkeHUh?=
NCI-H345 MnnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXvTWM2OD1|Nz6zOlI1KM7:TR?= NV;Oe4ZoW0GQR1XS
COLO-800 NHjzdIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfsR2VKSzVyPUO3MlU3PyEQvF2= MXPTRW5ITVJ?
COLO-320-HSR M17X[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nsOmlEPTB;M{iuN|Q6OiEQvF2= MorxV2FPT0WU
NCI-H596 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2OyTmlEPTB;M{iuOFQ5QSEQvF2= MVjTRW5ITVJ?
NCI-H187 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTN6LkezOFQh|ryP MlPBV2FPT0WU
ECC4 NFTaXoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTN7LkC4NVQh|ryP M1znVnNCVkeHUh?=
KP-4 M3X3XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHhcppKSzVyPUO5MlEzOzVizszN NUDDUWM5W0GQR1XS
NCI-H2227 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI[xfYJKSzVyPUO5MlM6PDlizszN NYTCOJYxW0GQR1XS
22RV1 M4npZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHrU5lCUUN3ME2zPU45Ozl6IN88US=> M4jhN3NCVkeHUh?=
SAS MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIntW2tKSzVyPUSwMlA6PiEQvF2= NVHGN4xUW0GQR1XS
PANC-10-05 Mkf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTRyLkG4Nlgh|ryP NWSyWHhsW0GQR1XS
MDA-MB-468 Mm[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Gz[mlEPTB;NECuOVM1PiEQvF2= M1TEVXNCVkeHUh?=
RPMI-7951 NHXLUJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3PTWM2OD12MT6yNFc2KM7:TR?= MUDTRW5ITVJ?
BB49-HNC MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXtTWM2OD12MT6yNVc6KM7:TR?= NUL1e4JjW0GQR1XS
23132-87 M2XLPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITw[2VKSzVyPUSxMlI4OzJizszN M4PwXXNCVkeHUh?=
HCC1569 M1Tvd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTRzLkK4PFUh|ryP NF7QTJlUSU6JRWK=
CP66-MEL Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXIPJQ4UUN3ME20Nk4yQDh4IN88US=> Mn\DV2FPT0WU
K-562 NIf2RoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjZTWM2OD12Mj6yPFU1KM7:TR?= MlLzV2FPT0WU
OCI-AML2 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorCTWM2OD12Mj64PVc1KM7:TR?= MlvIV2FPT0WU
SW756 NHHGNY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\QdWlEPTB;NEOuNFM5QCEQvF2= NH;Qe|VUSU6JRWK=
M14 NWO5SlhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknYTWM2OD12Mz6zNVg6KM7:TR?= MnvmV2FPT0WU
NCI-H1623 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDyTWM2OD12Mz60OlQh|ryP M4jhWHNCVkeHUh?=
KNS-81-FD M3;xc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\PTWM2OD12Mz63OlIh|ryP NF\YW4xUSU6JRWK=
TGBC1TKB NGrGWYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{ToVmlEPTB;NEOuPVA6QSEQvF2= MkftV2FPT0WU
RERF-LC-MS MmfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnNPWZvUUN3ME20N{46OjhzIN88US=> NX;odWZ7W0GQR1XS
PC-3 NHHNZ2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTR2LkSzOFch|ryP NGP5SpNUSU6JRWK=
HuP-T4 NYfxdY1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrxVZhKSzVyPUS0MlQ1PzRizszN NEXVNmpUSU6JRWK=
NCI-H510A NFHWfolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzZTWM2OD12ND63NFgh|ryP NH\lbo9USU6JRWK=
LB2518-MEL M1frTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DVdWlEPTB;NESuO|k{PyEQvF2= NETzeYZUSU6JRWK=
TE-5 NWPENWpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\0TWM2OD12NT65OVgyKM7:TR?= MnfLV2FPT0WU
EW-24 NGftbVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33zOmlEPTB;NE[uNVczOyEQvF2= MWXTRW5ITVJ?
LB647-SCLC NWmwdHRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTR4LkKxOVUh|ryP NYH2N5llW0GQR1XS
NCI-H524 NUPwR|lwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDVTWM2OD12Nj63NVg2KM7:TR?= NHToNWxUSU6JRWK=
EW-11 NX\UeHNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTR4LkmzO|Mh|ryP MkjEV2FPT0WU
KALS-1 NV;nW49PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTR5LkKwOlYh|ryP NELUbVlUSU6JRWK=
BT-474 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XaeGlEPTB;NEeuOFIyPiEQvF2= Mk\5V2FPT0WU
SK-N-AS MkP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHpTWM2OD12Nz64PFgh|ryP NH3qRnFUSU6JRWK=
HCC2157 NFTGN4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\2TWM2OD12OD6wO|Yh|ryP NF\TfGpUSU6JRWK=
HCC1954 MnnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLsTWM2OD12OD6xO|A1KM7:TR?= MlrCV2FPT0WU
FADU MnjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;FTGlEPTB;NEiuN|A{OSEQvF2= MWTTRW5ITVJ?
S-117 NFz5No5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTR6LkO4NVUh|ryP NEHmbJpUSU6JRWK=
LS-1034 M1O1SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzETWM2OD12OD63NFY4KM7:TR?= NIfGSFBUSU6JRWK=
CAMA-1 NX[yZYt1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTR7LkW1OFMh|ryP M3XVZ3NCVkeHUh?=
LU-134-A MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\RTWM2OD12OT64NFg2KM7:TR?= NUjONYxoW0GQR1XS
NCI-H1838 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXKOWU5UUN3ME20PU45ODh5IN88US=> NUDCO3BJW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pSrc / Src / pPlcg / Plcg / pStat5 / Stat5 ; 

PubMed: 22781593     


In (B) inhibition of Src, Plcg and Stat5 was seen in MLNAF cell lines treated with Ponatinib; ZNF112 expresses ZMYM2–FGFR1, CEP2A and CEP5A cells express CEP110–FGFR1 and BBC2 expresses BCR–FGFR1.

pFGFR1(pY20) / FGFR1; 

PubMed: 22781593     


Western blot analysis, using various antibodies specific for downstream targets of FGFR1, demonstrates that Ponatinib inhibits the activation of Plcg and Src as a result of inhibiting the FGFR1 fusion kinase in human KG1 cells. 

cleaved caspase-3 / cleaved caspase-7 / BAX / Bcl-2; 

PubMed: 30959969     


Western blot analysis of cleaved caspase-3, cleaved caspase-7, Bax, Bcl-2, and β-Tubulin (control) in treated cells.

p-Rb(S807/811) / Rb / CDK4 / CDK6 / Cyclin D1 / CDK2 / Cyclin E1; 

PubMed: 30959969     


Western blot analysis of Rb/p-Rb, CDK4, CDK6, Cyclin D1, CDK2, Cyclin E1, and β-Tubulin (control) in the SK-Hep-1 and SNU-423 cells treated with ponatinib. 

RAD51; 

PubMed: 30959969     


The effect of ponatinib on the concentration of Rad51 in SK-Hep-1 and SNU-423 cells.

p-MEK / MEK / p-ERK / ERK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Mek and Erk. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

c-Jun / p-JNK(T183/Y185) / JNK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of JNK and c-Jun. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-p38 MAPK / p38 MAPK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of p38. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-JAK2 / JAK2 / p-STAT3 / STAT3; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Jak2, and Stat3. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

PI3K p85 / p-PI3K / p-PDK1 / PDK1 / p-mTOR / mTOR; 

PubMed: 30959969     


Effects of ponatinib on the protein concentration and phosphorylation of PI 3-kinase, PDK1, Akt, and mTOR in HCC cells. 

p-PDGFRα / PDGFRα; 

PubMed: 24472312     


Ponatinib inhibited phosphorylation of PDGFRα in a concentration-dependent manner. EOL-1 and BaF3-WT or -T674I FIP1L1-PDGFRα cells were exposed to escalating concentrations of ponatinib for 24 h.

PARP / Caspase-3 / Active Caspase-3; 

PubMed: 24472312     


The concentration- (for 24 h) and time-dependent (1 nM for EOL-1, 300 nM for BaF3-WT and -T674I FIP1L1-PDGFRα cells) cleavage of PARP and caspase-3 triggered by ponatinib was analyzed by immunoblotting.

AIF / Cyto C ; 

PubMed: 24472312     


Ponatinib elicited release of AIF and cytochrome c into the cytosol. Cells were treated with 1 nM ponatinib for the indicated durations and the cytosolic fraction was extracted with digitonin buffer. Levels of AIF and Cytochrome c (Cyto c) were detected by immunoblotting.

Mcl-1 / Survivin / Bcl-Xl / XIAP / Bax / Bcl-2 / Bim; 

PubMed: 24472312     


Immunoblotting of apoptosis-related proteins in CEL cells after treatment for 24 h.

β-catenin ; 

PubMed: 24472312     


Ponatinib concentration-dependently lowered β-catenin. EOL-1 cells were incubated with ponatinib for 24 h, and cytoplasmic and nuclear extracts were determined by immunoblotting.

β-catenin; 

PubMed: 24472312     


Analysis of β-catenin localization. EOL-1 cells were pretreated with 1 nM ponatinib for 24 h, immunofluorescence analysis was performed with anti-β-catenin. Nuclei were stained with 4,6-diamidino-2-phenylindole (DAPI). 

ABL; 

PubMed: 19878872     


In vitro [γ-32P]-ATP autophosphorylation of full-length (A) ABL or (B) ABLT315I kinase treated with AP24534, imatinib, nilotinib, or dasatinib. After incubation of tyrosine-dephosphorylated enzyme with the indicated inhibitor in the presence of [γ-32P]-ATP and separation by SDS-PAGE, signal intensity was measured by autoradiography.

22781593 30959969 24472312 19878872
Growth inhibition assay
Cell viability; 

PubMed: 30174789     


(A) Effect of Ponatinib on basal viability of HUVECs. The cells were treated with Ponatinib at indicated concentrations or 0.1% DMSO (vehicle control) for 24 h.

30174789
体内研究 Ponatinib抑制取自FLT3-ITD阳性AML病人的原代白血病细胞,而不抑制表达阴性FLT3的AML病人的白血病细胞。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
- 合并

激酶实验:

通过同质时间分辨荧光共振能量转移法(TR-FRET),使用纯化的人类野生型ABL激酶,T315I突变型ABL激酶,及生物素化的磷酸激酶底物肽: 生物素-EKKMAAEAIYAAPFAK-NH2,测定野生型ABL和T315I突变型ABL活性的抑制激酶反应在全LANCE激酶buffer (LKB)中进行,LKB包括20 mM NaHEPES(pH 为7.4), 0.1 mg ⁄ mL BSA, 1 mM ATP, 10 mM MgCl2, 及0.41 mM DTT,在提前用1% BSA(溶于PBS)包被的96孔板上4oC下过夜。用于激酶反应,Ponatinib稀释物和野生型ABL, T315I突变型ABL (40 pM), 及底物肽(50 nM), 在室温下温育1小时(T315I突变型ABL)或2小时(野生型ABL)。加入15 nM 抑制剂, 6 nM 铕标记的磷酸酪氨酸抗体(磷酸化位点在第66为酪氨酸上),及60 nM 别藻蓝素标记的链酶亲和素,终止反应。实验板在室温下黑暗温育20分钟,使用Wallac Victor2V读数器读取615和665nm处的荧光值。在孔中数据平均值中插入抑制剂的3倍连续稀释液,再读取665nm处荧光值,计算IC50值。
细胞实验:[1]
- 合并
  • Cell lines: Ba ⁄ F3细胞
  • Concentrations: 0-625 nM, 和0-10 µM
  • Incubation Time: 72小时
  • Method: Ba/F3细胞系按每孔4×103个细胞分布在96孔板上(4×103),和梯度浓度Ponatinib温育72小时。Ponatinib浓度范围为: 0-625 nM 作用于表达BCR-ABL细胞,0-10 µM 用于测定BCR-ABL阴性细胞。使用MTS实验测定细胞增殖,取三次平行实验平均值测定IC50值。
    (Only for Reference)
动物实验:[3]
- 合并
  • Animal Models: 皮下植入MV4-11细胞移植瘤(1×107,50%基质胶中) 的雌性CB.17 SCID鼠
  • Formulation: 25 mmol/L柠檬酸盐缓冲液(pH 为2.75)
  • Dosages: 每天处理一次,持续4周
  • Administration: 口服饲喂处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
1% CMC Na
30mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 532.56
化学式

C29H27F3N6O

CAS号 943319-70-8
储存条件 粉状
溶于溶剂
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04070443 Not yet recruiting Drug: Ponatinib|Drug: Imatinib Philadelphia Chromosome Positive CML|BCR-ABL Positive Chronic Myelogenous Leukemia Centre Leon Berard October 1 2019 Phase 2
NCT03934372 Not yet recruiting Drug: Ponatinib Acute Myeloid Leukemia|Accelerated Phase Chronic Myeloid Leukemia|Blast Phase Chronic Myeloid Leukemia|Chronic Phase Chronic Myeloid Leukemia|Acute Lymphoblastic Leukemia|Acute Lymphocytic Leukemia|Leukemia|Lymphoma|Solid Tumors Incyte Biosciences International Sàrl|Incyte Corporation October 25 2019 Phase 1|Phase 2
NCT03895671 Recruiting Drug: Ponatinib|Drug: Azacitidine CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE|CHRONIC MYELOGENOUS LEUKAEMIA IN MYELOID BLAST CRISIS Versailles Hospital June 19 2019 Phase 2
NCT03690115 Recruiting Drug: Ponatinib 30 MG Leukemia Myeloid Acute Versailles Hospital December 12 2018 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID