Ponatinib (AP24534)

For research use only. Not for use in humans.

目录号:S1490

Ponatinib (AP24534) Chemical Structure

CAS No. 943319-70-8

Ponatinib (AP24534)是一种新型有效的多靶点抑制剂,在无细胞试验中作用于Abl,PDGFRα,VEGFR2,FGFR1和Src,IC50分别为0.37 nM,1.1 nM,1.5 nM,2.2 nM和5.4 nM。Ponatinib (AP24534)可抑制自噬。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 819.31 现货
RMB 903.01 现货
RMB 3034.48 现货
RMB 7959.08 现货
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客户使用Selleck生产的Ponatinib (AP24534)发表文献98篇:

产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

产品描述 Ponatinib (AP24534)是一种新型有效的多靶点抑制剂,在无细胞试验中作用于Abl,PDGFRα,VEGFR2,FGFR1和Src,IC50分别为0.37 nM,1.1 nM,1.5 nM,2.2 nM和5.4 nM。Ponatinib (AP24534)可抑制自噬。
靶点
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外研究

Ponatinib是有效的可用于口服的多靶点激酶抑制剂,作用于野生型细胞,及T315I 突变细胞IC50分别为1.2和8.8nM。[1] Ponatinib抑制Ba/F3衍生细胞系的增殖。[2] Ponatinib作用于表达野生型或T315I突变型BCR-ABL的CML细胞系,有效抑制BCR-ABL调节的信号。Ponatinib阻断在细胞瘤筛选时产生抗性突变。[3] Ponatinib也抑制VEGFR和FGFR家族激酶,在体外抑制FLT3, KIT, FGFR1,和PDGFRa激酶活性时IC50分别为13, 13, 2, 和1 nM.[4]Ponatinib抑制全部4种RTKs磷酸化,存在剂量依赖性,IC50值为0.3到20 nM。然而,Ponatinib抑制表达野生型FLT3的RS4;11细胞时IC50>100 nM。

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NUPtV4hMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPuUJJSUUN3ME2wMlAxODByMECzOVkh|ryP MYPTRW5ITVJ?
MV-4-11 MnzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXqdndKSzVyPUCuNFAxODl3NjFOwG0> NYLoN5RoW0GQR1XS
MEG-01 M{[yOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnm0TWM2OD1yLkCwNFEzQCEQvF2= NViwSmZKW0GQR1XS
LAMA-84 NIC5VnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLmSHJKSzVyPUCuNFAxOTZ3IN88US=> NV7LPGVrW0GQR1XS
CGTH-W-1 M1nXbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnKPIlKSzVyPUCuNFAyPjlizszN Mom0V2FPT0WU
KASUMI-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rtTWlEPTB;MD6wNFIyPyEQvF2= M1Hr[HNCVkeHUh?=
BE-13 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3CV2xKSzVyPUCuNFAzPTlizszN NUXmVGR[W0GQR1XS
CTV-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrZU5ZKSzVyPUCuNFA2OjFizszN MlKxV2FPT0WU
NKM-1 MmDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUm3SYluUUN3ME2wMlAxPjV3IN88US=> NFrROlBUSU6JRWK=
MONO-MAC-6 NYHQVoQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHlTWM2OD1yLkCwPFM4KM7:TR?= M2\zUnNCVkeHUh?=
A204 M{CyWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvuR2Y6UUN3ME2wMlAyOjF6IN88US=> NGXQOI5USU6JRWK=
GDM-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMEG4N|Mh|ryP NGLYOo5USU6JRWK=
AN3-CA NIDOTXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXnVlBOUUN3ME2wMlAyQDd|IN88US=> MXrTRW5ITVJ?
BL-70 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4q0PWlEPTB;MD6wNlE6QSEQvF2= MX3TRW5ITVJ?
Daudi MlnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXvdo9KSzVyPUCuNFI2OzdizszN Mn\mV2FPT0WU
KU812 M13mfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7ZTWM2OD1yLkCyPFQ5KM7:TR?= NHTi[4hUSU6JRWK=
KG-1 NI\zTG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrhOlFKSzVyPUCuNFMzQTRizszN M3jqbHNCVkeHUh?=
DOHH-2 M4ruVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonwTWM2OD1yLkC0PFA{KM7:TR?= NX75PGcxW0GQR1XS
HuO9 NHHsRoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\BRVU3UUN3ME2wMlA2PDR6IN88US=> MVfTRW5ITVJ?
EB2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHFVIdmUUN3ME2wMlA2PTd4IN88US=> MnP0V2FPT0WU
G-402 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjEdmxKSzVyPUCuNFY{PDFizszN MYXTRW5ITVJ?
SU-DHL-1 NXH6[5lET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3yNpM1UUN3ME2wMlA3Ozd7IN88US=> NF;XSGNUSU6JRWK=
NCI-H719 NGL0e5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[2U482UUN3ME2wMlA4QDh6IN88US=> NHnsbFVUSU6JRWK=
MLMA MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLjTWM2OD1yLkC5NFYh|ryP MY\TRW5ITVJ?
KM12 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMEm3N|ch|ryP NY\kbI1sW0GQR1XS
SUP-T1 MkTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLNd2pKSzVyPUCuNFk6QDJizszN Ml25V2FPT0WU
MZ1-PC MlHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\iTWM2OD1yLkGxN|M3KM7:TR?= M4PxRXNCVkeHUh?=
MFE-296 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXpTWM2OD1yLkGxPFM6KM7:TR?= MXrTRW5ITVJ?
ALL-PO MkHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LVdWlEPTB;MD6xNlQ1OyEQvF2= MoHRV2FPT0WU
GB-1 NGrwWmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPLfJdKSzVyPUCuNVI2OTJizszN M1nEd3NCVkeHUh?=
SIG-M5 M4\5bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMUOzO{DPxE1? NEi2dppUSU6JRWK=
P30-OHK NX\KNFhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{m0NWlEPTB;MD6xOVY4OiEQvF2= NXXOSnVYW0GQR1XS
NCI-H716 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPKSZdKSzVyPUCuNVYzPjZizszN MXfTRW5ITVJ?
MPP-89 MlfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMU[5N|Mh|ryP MlWwV2FPT0WU
SF126 MnG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;KVGlEPTB;MD6xO|A3OyEQvF2= MkT0V2FPT0WU
CTB-1 NHHrNmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXCSYZKSzVyPUCuNVc{OTZizszN M4jlSnNCVkeHUh?=
CA46 NIrmcFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUOyXJZxUUN3ME2wMlE4PDh7IN88US=> M3fCbnNCVkeHUh?=
NCI-H520 M1TOTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjGNZhKSzVyPUCuNVc4OzJizszN M2DPSXNCVkeHUh?=
CAL-85-1 NYPvc2VjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LiNWlEPTB;MD6xO|kzPyEQvF2= NYXpSItsW0GQR1XS
NCI-H2342 NXv2eXZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXiTHhNUUN3ME2wMlE5PTd5IN88US=> M3XPOHNCVkeHUh?=
697 Ml\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\0b|NNUUN3ME2wMlE5QDdzIN88US=> MkLCV2FPT0WU
NY MoXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\JcWM6UUN3ME2wMlE6Ojh5IN88US=> MUjTRW5ITVJ?
T98G NVnMO|g2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjlXYtnUUN3ME2wMlE6OzF6IN88US=> NFztTpBUSU6JRWK=
NCI-H1703 M2\UVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDYTWM2OD1yLkG5OlE2KM7:TR?= MoT6V2FPT0WU
NCI-H2087 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfyN2JKSzVyPUCuNlA1OzlizszN MWPTRW5ITVJ?
PF-382 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMkC4O|Mh|ryP MnHRV2FPT0WU
HCT-116 MmrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMkGwOlkh|ryP NV;QO4MzW0GQR1XS
CAKI-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnO1TWM2OD1yLkKxOlY3KM7:TR?= NGnMb25USU6JRWK=
CCF-STTG1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;YTWM2OD1yLkKyOFc2KM7:TR?= NFjidXZUSU6JRWK=
D-392MG M3nvRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLvfVVKSzVyPUCuNlMyPzdizszN MWTTRW5ITVJ?
RT-112 M16wUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMkO3PVUh|ryP NHTYZ3BUSU6JRWK=
MES-SA M33JXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\tTGlEPTB;MD6yOFE5PyEQvF2= MXjTRW5ITVJ?
LC-2-ad NE\Qb4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLISo1nUUN3ME2wMlI1OjZ3IN88US=> NYnqO4tnW0GQR1XS
NOS-1 NV7tc3d2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIj0fHBKSzVyPUCuNlQ{PjdizszN MYnTRW5ITVJ?
NALM-6 M2\xNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PnNWlEPTB;MD6yOVU1OyEQvF2= Mn\kV2FPT0WU
TE-15 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF30SWhKSzVyPUCuNlYxQTFizszN MlXZV2FPT0WU
786-0 NX\YVnJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH71WWVKSzVyPUCuNlYzOjhizszN NIrZcG9USU6JRWK=
IST-MES1 NGG4dZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrXT445UUN3ME2wMlI3QDJ7IN88US=> Mn7PV2FPT0WU
KYSE-180 NUP1UnZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMk[4PVEh|ryP MkTiV2FPT0WU
YT Mk\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\3R2lEPTB;MD6yOlk4PCEQvF2= NVLEcZVrW0GQR1XS
A427 NY[0Tmx6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;oTWM2OD1yLkK3NlY1KM7:TR?= MUjTRW5ITVJ?
KYSE-450 NUT5TXM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPEdnNKSzVyPUCuNlc{OjlizszN M2D6OXNCVkeHUh?=
HuH-7 MoLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMke3OlMh|ryP MVTTRW5ITVJ?
CAS-1 M1nVWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjPW2ZrUUN3ME2wMlI5OzB|IN88US=> M{PKN3NCVkeHUh?=
KURAMOCHI MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMki0NVkh|ryP NIW3eWtUSU6JRWK=
ACHN NVTW[ZJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMkmzNlMh|ryP MWXTRW5ITVJ?
HGC-27 MmXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwMkmzOVMh|ryP NWTGbnlXW0GQR1XS
A172 M{Dabmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMkm1O|ch|ryP NWnLWJJbW0GQR1XS
SNU-449 NX\ROJV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TVZ2lEPTB;MD6yPVk3PCEQvF2= NYO3N|lDW0GQR1XS
SW982 NFK1folIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMkm5O|gh|ryP MWXTRW5ITVJ?
EFO-21 MmDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrr[o5KSzVyPUCuN|A1OTFizszN NWD6Zmo3W0GQR1XS
NCI-H2030 M2\uXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfKTWM2OD1yLkOxNVY1KM7:TR?= M3\XSnNCVkeHUh?=
HT-144 NFLyXoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvQOJlwUUN3ME2wMlMyOjhizszN M{W2fXNCVkeHUh?=
MFE-280 NWm3[pBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwM{G0OVMh|ryP NHfqOGRUSU6JRWK=
SK-LU-1 MmSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnr4TWM2OD1yLkOxOFY3KM7:TR?= MV7TRW5ITVJ?
NCI-H2052 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rDOmlEPTB;MD6zNVQ5PCEQvF2= NFfuc|BUSU6JRWK=
SK-HEP-1 NX\Ub4xET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGL0b2pKSzVyPUCuN|M{PjhizszN NVPGWnh{W0GQR1XS
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A2780 M4q1TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDlOWxHUUN3ME2wMlM1OzB2IN88US=> NFvvUZVUSU6JRWK=
ACN NHzISndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInGWldKSzVyPUCuN|Q5PzNizszN M1qzNXNCVkeHUh?=
BxPC-3 NIDScVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwM{S5PFkh|ryP M4D2WnNCVkeHUh?=
BCPAP NGW2e2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwM{[wNFEh|ryP MYfTRW5ITVJ?
HOP-62 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Xwd2lEPTB;MD6zOlExPiEQvF2= MnTvV2FPT0WU
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OPM-2 NFnIbWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rQfWlEPTB;MD6zOlQ4OyEQvF2= NVm3fnl2W0GQR1XS
DBTRG-05MG MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHaVZNiUUN3ME2wMlM5ODV2IN88US=> M3\HNnNCVkeHUh?=
SK-MEL-24 Ml:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHY[29KSzVyPUCuN|k4QTFizszN MlXZV2FPT0WU
8305C M3Premdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2robGlEPTB;MD6zPVc6OyEQvF2= MV7TRW5ITVJ?
OVCAR-4 MkP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LvfmlEPTB;MD60NVU5PiEQvF2= MljPV2FPT0WU
HLE NUDW[4J2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwNEG4OkDPxE1? MojnV2FPT0WU
NCI-H747 NHrrXGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXmzXYliUUN3ME2wMlQzOTN5IN88US=> NFHnNZdUSU6JRWK=
SW780 NYKxU4d5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzRRldKSzVyPUCuOFI{PDZizszN MmLFV2FPT0WU
KYSE-150 M2myZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXtd2JCUUN3ME2wMlQzPDF3IN88US=> NWLD[IZGW0GQR1XS
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SW1088 NHm3OmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfyTWM2OD1yLkS0N|kh|ryP NXzYUpR3W0GQR1XS
SF268 M3HnbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mli1TWM2OD1yLkS0PFYh|ryP M17SWHNCVkeHUh?=
RT4 MmPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPNd2JFUUN3ME2wMlQ2OTFzIN88US=> NYm3N4w5W0GQR1XS
NCI-H522 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2KyVmlEPTB;MD60OVI4KM7:TR?= NYS0[GttW0GQR1XS
LCLC-97TM1 NHjiOYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwNE[xPVUh|ryP MYXTRW5ITVJ?
CAL-39 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwNE[1NVkh|ryP NVvocm06W0GQR1XS
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ESS-1 Ml;hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HvbGlEPTB;MD60O|gzOSEQvF2= MoK3V2FPT0WU
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VMRC-RCZ NWPOT|lIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFGx[GlKSzVyPUCuOFk6ODRizszN NH7zNIlUSU6JRWK=
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MOLT-16 NYPrTlRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwNUG4NFgh|ryP MYPTRW5ITVJ?
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L-428 MlfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnv0TWM2OD1zLkm5NVc6KM7:TR?= MnnZV2FPT0WU
KM-H2 NF\UWVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTJwMEGwPUDPxE1? NVfPSG1rW0GQR1XS
MC-IXC NU\Bb5dST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljDTWM2OD1{LkCyNlc{KM7:TR?= M3nFTHNCVkeHUh?=
COLO-678 M1;wVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTJwMESyNFch|ryP NX3kTXk3W0GQR1XS
MEL-JUSO MljKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTJwMEe4OVEh|ryP M2XyN3NCVkeHUh?=
HCC38 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj0TWM2OD1{LkC4OFM{KM7:TR?= NH[wTotUSU6JRWK=
UACC-62 MnLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTJwMEi4OVUh|ryP MV3TRW5ITVJ?
OAW-42 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrmS45UUUN3ME2yMlA6PzFzIN88US=> NYPOdIM5W0GQR1XS
LB996-RCC M2fnUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfUTWM2OD1{LkGzPFE4KM7:TR?= MVnTRW5ITVJ?
COR-L105 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjTeGpjUUN3ME2yMlE3Ozd|IN88US=> MV3TRW5ITVJ?
RCC10RGB NILnW2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{[wPGlEPTB;Mj6xPFU4PiEQvF2= MVXTRW5ITVJ?
A431 NYmyS|dIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITGeFVKSzVyPUKuNVkxOTlizszN NIfkXGRUSU6JRWK=
NCI-H292 NUHmRnBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfxTWM2OD1{LkKzPVUyKM7:TR?= MkToV2FPT0WU
SK-UT-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTJwM{OxPFQh|ryP M3exPXNCVkeHUh?=
PANC-08-13 NGfCXJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fVOGlEPTB;Mj6zN|I{PSEQvF2= M2ruVXNCVkeHUh?=
ST486 NHfCXoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rl[2lEPTB;Mj60NVA1QCEQvF2= M1Wxd3NCVkeHUh?=
SJSA-1 MkmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTJwNEGyO|Eh|ryP Mn7qV2FPT0WU
RKO M1HyT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkSwTWM2OD1{LkSyNFI6KM7:TR?= MnfrV2FPT0WU
NCI-H1793 MnrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX0Om5KSzVyPUKuOFQxOjlizszN NG[1SYFUSU6JRWK=
639-V MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\UcGlEPTB;Mj60OVM5OiEQvF2= NYrwRWtpW0GQR1XS
ES3 NVjVWJo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELBWWlKSzVyPUKuOFk4OzdizszN NHHxVZhUSU6JRWK=
NCI-H1792 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlH0TWM2OD1{LkW2PFI3KM7:TR?= MlHQV2FPT0WU
NCI-H1651 MlLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHLbYRKSzVyPUKuOVgzOSEQvF2= Moi5V2FPT0WU
SN12C NVPDfHdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHm[YFmUUN3ME2yMlU5PDh5IN88US=> NWDhfpI5W0GQR1XS
COLO-679 NEjmZ5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NID4OmJKSzVyPUKuOVg3ODVizszN NHLxNIVUSU6JRWK=
U-118-MG NXO0TIc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInJe|ZKSzVyPUKuOVg5PzJizszN NYTLUZdJW0GQR1XS
Ramos-2G6-4C10 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJwNkS4NFch|ryP MY\TRW5ITVJ?
HCT-15 NV\TbZJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jtRmlEPTB;Mj62PFc6OiEQvF2= MmW4V2FPT0WU
MDA-MB-157 NU[5c2d4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWT6XXpuUUN3ME2yMlcxPzR5IN88US=> M{n2UXNCVkeHUh?=
K5 NFXVNWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfsRllpUUN3ME2yMlcyQDR3IN88US=> NWTyOFNVW0GQR1XS
MKN45 NHLqOlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr2W3JKSzVyPUKuO|M{PjZizszN MWPTRW5ITVJ?
DMS-273 M3jORWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWCxT2FmUUN3ME2yMlc2PjN{IN88US=> MWfTRW5ITVJ?
C8166 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7MdXdKSzVyPUKuO|g2OTNizszN MlfTV2FPT0WU
Calu-3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTJwN{i5Olkh|ryP M{\ocXNCVkeHUh?=
SNB75 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVH2WZNOUUN3ME2yMlg5PTN3IN88US=> M3PiSHNCVkeHUh?=
BFTC-905 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHr3dY9KSzVyPUKuPVAyQTFizszN Mkj5V2FPT0WU
C-4-II NFrnbFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrhTWM2OD1{LkmxN|U{KM7:TR?= MWLTRW5ITVJ?
MS-1 NIXhS5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofGTWM2OD1{Lkm2O|Y6KM7:TR?= M1TkU3NCVkeHUh?=
A375 NU\FNItMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\TUYNTUUN3ME2zMlA5OTh2IN88US=> M{LPW3NCVkeHUh?=
KYSE-70 NWHiT3VGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmOwTWM2OD1|LkC4PFgzKM7:TR?= MkPqV2FPT0WU
KYSE-510 MljtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\ucXBTUUN3ME2zMlExQTl3IN88US=> NGraVIhUSU6JRWK=
LN-405 NGjje3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\ze2lEPTB;Mz6xN|UyQCEQvF2= NFPDPWRUSU6JRWK=
BOKU MkH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rFbGlEPTB;Mz6xOFI2PiEQvF2= MmnGV2FPT0WU
TE-10 NVTmPJVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XCUGlEPTB;Mz6xO|M3OiEQvF2= M{XPUHNCVkeHUh?=
MKN1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDLTJM6UUN3ME2zMlE5PDh|IN88US=> NF;CXJVUSU6JRWK=
M059J MnXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\RTnBKSzVyPUOuNlAyPzNizszN NInUOFZUSU6JRWK=
GOTO M1rESmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTNwMkKwN|kh|ryP M2nXRXNCVkeHUh?=
DK-MG MlfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPVWodkUUN3ME2zMlI2QTd4IN88US=> M{fLcHNCVkeHUh?=
NCI-H727 NV3aZoo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{j6bWlEPTB;Mz6yOlU5KM7:TR?= MoLzV2FPT0WU
NB12 MkXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVy3TJY5UUN3ME2zMlM{OjJ2IN88US=> Mm[5V2FPT0WU
DOK MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTNwM{[xPFYh|ryP M4jHUHNCVkeHUh?=
KYSE-410 NHnwOmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLpc2dFUUN3ME2zMlM3Ojh5IN88US=> NF\F[WpUSU6JRWK=
AM-38 NH3FSW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGK4dpdKSzVyPUOuN|gxPTFizszN MXTTRW5ITVJ?
GR-ST M3f0VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTNwNEW3N|Ih|ryP NWqxPGtkW0GQR1XS
D-247MG Mm\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3f3emlEPTB;Mz60PFI3OyEQvF2= Mn7sV2FPT0WU
TE-8 NF3sUGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYGxSo9sUUN3ME2zMlQ6OzN|IN88US=> NXzFXVhDW0GQR1XS
LS-411N MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnUTYdXUUN3ME2zMlQ6Pjl{IN88US=> M2rBfnNCVkeHUh?=
SK-MES-1 MlK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTNwNU[0N|Mh|ryP Mkj5V2FPT0WU
SF295 M4TLN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWT4eZNSUUN3ME2zMlYyPTV{IN88US=> MnHyV2FPT0WU
SK-MEL-30 NXHHbZdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIridVdKSzVyPUOuOlU6OjFizszN NWPpc5p3W0GQR1XS
LB2241-RCC NFztU5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7GSVFKSzVyPUOuOlYzPiEQvF2= MUTTRW5ITVJ?
PC-14 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjpZXdsUUN3ME2zMlY3PDN5IN88US=> NIj2SXRUSU6JRWK=
EW-7 MlvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTNwNke2PVMh|ryP NGfvfFlUSU6JRWK=
NMC-G1 M1TLdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvRTWM2OD1|LkexPFM4KM7:TR?= MUnTRW5ITVJ?
TE-441-T MmHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTNwN{OwNlgh|ryP MlHQV2FPT0WU
NCI-H1618 MoG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvEb3JKSzVyPUOuPFE5PzVizszN M4nzdHNCVkeHUh?=
PANC-03-27 NWjOOlZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zZ[WlEPTB;Mz64NVkyPiEQvF2= M1fkVHNCVkeHUh?=
NCI-H2228 MnfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jqfmlEPTB;Mz64N|EzPiEQvF2= MlzmV2FPT0WU
CAPAN-1 MmLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWmwcpBRUUN3ME2zMlg4ODB7IN88US=> NULM[npDW0GQR1XS
KLE NXzkTYRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfmUo9KSzVyPUOuPVA3PyEQvF2= NUnE[YZIW0GQR1XS
Becker NECyRXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTNwOUK4OFkh|ryP MoLVV2FPT0WU
SK-PN-DW NVTkS4drT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmC5TWM2OD12LkC3PVc1KM7:TR?= MonkV2FPT0WU
Hs-578-T MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTRwMEizNFYh|ryP M2izeHNCVkeHUh?=
RS4-11 NHy4fVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3KzfmlEPTB;ND6xNVI2PSEQvF2= M{T5SXNCVkeHUh?=
D-502MG NXXWOpZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFu0e2lKSzVyPUSuNVY6QTdizszN MYXTRW5ITVJ?
GI-1 M2H4Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTRwMkiyPVkh|ryP NVPzSFFQW0GQR1XS
NCI-H209 NH;rdFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUT5SmwyUUN3ME20MlM{PzhizszN NYfjV3dFW0GQR1XS
SK-OV-3 MnWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInmXmxKSzVyPUSuOFgyPDlizszN MUTTRW5ITVJ?
LOUCY NFLxNphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlyzTWM2OD12LkS4OFMzKM7:TR?= MWXTRW5ITVJ?
NCI-H69 M363Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLYTWM2OD12LkWxO|k{KM7:TR?= NFrZTJJUSU6JRWK=
SCC-9 M3z4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzsWnVKSzVyPUSuOVMyPzJizszN M4jKWnNCVkeHUh?=
NCI-H526 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTRwNUmyPVMh|ryP M{C5NnNCVkeHUh?=
NCI-H2170 M{XVVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fodWlEPTB;ND62Olc4OSEQvF2= NYnKbJE5W0GQR1XS
SR NUDB[pJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTRwN{CwOFgh|ryP NX\pVZI1W0GQR1XS
CMK MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjyTWM2OD12LkeyNVAyKM7:TR?= NXz5SFF5W0GQR1XS
COLO-829 MlPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTRwN{ewOFMh|ryP MnHWV2FPT0WU
HuO-3N1 MmHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7XbW9KSzVyPUSuPFMzQDFizszN M1K1UXNCVkeHUh?=
5637 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTRwOUC0PFch|ryP MkLzV2FPT0WU
A253 Mn74S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTRwOUe3NFgh|ryP MXjTRW5ITVJ?
NB10 MlftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILjbW5KSzVyPUWuNFc1QTdizszN MkHoV2FPT0WU
SF539 NHPpVmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nPXWlEPTB;NT6wPVk2QSEQvF2= NHfCSItUSU6JRWK=
HAL-01 M4H2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVe2PGJIUUN3ME21MlE1PjR3IN88US=> NFPweFBUSU6JRWK=
MHH-ES-1 NYfrd5NLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUS1cHpjUUN3ME21MlE3QTJ3IN88US=> M{n1RXNCVkeHUh?=
DEL M1i3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDDTWM2OD13LkK3OVgzKM7:TR?= NELqfVlUSU6JRWK=
NCI-H1299 M17mNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTVwM{WwNFch|ryP MX3TRW5ITVJ?
ChaGo-K-1 NGj5VGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjKPZFuUUN3ME21MlM2OTB5IN88US=> NFLodGtUSU6JRWK=
HMV-II NUPxO3hHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHMe45KSzVyPUWuN|k1OyEQvF2= MUTTRW5ITVJ?
NB69 NGWyeZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{G4cWlEPTB;NT6zPVY{OSEQvF2= NUTQcIx6W0GQR1XS
NCI-H1882 M3XzO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLPUnM{UUN3ME21MlQ{OzZ2IN88US=> M3rHdHNCVkeHUh?=
SNU-475 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjETWM2OD13LkS3NVcyKM7:TR?= MkntV2FPT0WU
RXF393 NI[5VJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTVwNEi0PVQh|ryP MV;TRW5ITVJ?
CAL-51 NGjBWmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzPUHNQUUN3ME21MlYzQDV|IN88US=> MYjTRW5ITVJ?
SW1573 NF;ENlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PXeWlEPTB;NT62N|U{PCEQvF2= NWfIXXJxW0GQR1XS
GCT MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvwWYhrUUN3ME21Mlc2QTJ7IN88US=> NFm3eIpUSU6JRWK=
COR-L88 MmX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvPWJRmUUN3ME21Mlc3QDR4IN88US=> M3XZV3NCVkeHUh?=
MDA-MB-134-VI MnvaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLkVJJEUUN3ME21Mlg4PTN4IN88US=> MXfTRW5ITVJ?
NB5 NXf4RYtDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LSNWlEPTB;NT65NlQ1KM7:TR?= MWrTRW5ITVJ?
GMS-10 NV:wWndiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVftVpRzUUN3ME21Mlk3QDZzIN88US=> NW\EN2p2W0GQR1XS
CHP-212 NVvLS5pNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnTenY2UUN3ME22MlQ5OjZ5IN88US=> MoTJV2FPT0WU
TE-11 NV;abnRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfBTWM2OD14LkW1NVgzKM7:TR?= NXyxXGJ1W0GQR1XS
SW962 M1LoTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTZwNkW3O|Qh|ryP M2jKNXNCVkeHUh?=
MZ2-MEL NULnRZI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLvTWM2OD14LkiyNFEyKM7:TR?= NFWzT3RUSU6JRWK=
C-33-A NHi5NIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTZwOUG2PFgh|ryP M2C1NHNCVkeHUh?=
IGR-1 MorrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYOwRpZ7UUN3ME22Mlk4QDJ4IN88US=> NVLifVlyW0GQR1XS
MOLT-4 M1vadmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLreGRSUUN3ME23MlE2PDB4IN88US=> MVLTRW5ITVJ?
NCI-H1650 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTdwMkewOFYh|ryP M{nLc3NCVkeHUh?=
AsPC-1 NULIelduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\JTWM2OD15LkK4OlA2KM7:TR?= M3;ydXNCVkeHUh?=
SNU-C2B M2O0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTMTWM2OD15LkK5OVcyKM7:TR?= MWLTRW5ITVJ?
MKN7 NIjlb45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nvXGlEPTB;Nz6zO|I{PSEQvF2= NX[3TWVNW0GQR1XS
SW620 NV;PNnpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7sWXZKSzVyPUeuN|gzODVizszN NGrIO|dUSU6JRWK=
SK-MEL-28 NWTxVI5GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTdwNEC3PVgh|ryP NV\DfpJQW0GQR1XS
TE-6 M2f5dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU[4NoxxUUN3ME23MlQ1QTB6IN88US=> MVzTRW5ITVJ?
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BB65-RCC M3T6Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXkWZlrUUN3ME2yN{4xOzR2IN88US=> NXPWOo9JW0GQR1XS
SiHa M3HIVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vqS2lEPTB;MkOuN|k3QCEQvF2= NWDmRoxHW0GQR1XS
NCI-H2081 NUXPSVZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlToTWM2OD1{ND6wOlQyKM7:TR?= NWL5W5ZRW0GQR1XS
U251 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnzR3FSUUN3ME2yOE4xPjZ6IN88US=> MUPTRW5ITVJ?
LoVo M3;TXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHMOmVKSzVyPUK0MlkzQDJizszN NUjWUWpbW0GQR1XS
GCIY Mk[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPmeZNFUUN3ME2yOU4zQDd5IN88US=> M3PaTnNCVkeHUh?=
NUGC-3 Mk[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\USXBKSzVyPUK1MlM{OTZizszN NVrMdYF6W0GQR1XS
LNCaP-Clone-FGC M1rLXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\CTWM2OD1{NT6zOFk5KM7:TR?= NYPnRXpZW0GQR1XS
PA-1 Mn3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LkbmlEPTB;MkWuOlg{OyEQvF2= MlO4V2FPT0WU
OE33 NVP1[WtRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfYTWM2OD1{NT62PFU{KM7:TR?= MXLTRW5ITVJ?
HT-29 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\ldGlEPTB;MkWuO|g4QSEQvF2= M1TvdHNCVkeHUh?=
RCM-1 NV;WUGhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlu0TWM2OD1{NT65OlU3KM7:TR?= MXTTRW5ITVJ?
NCI-H1522 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PwNmlEPTB;MkWuPVkyOSEQvF2= MknvV2FPT0WU
LB373-MEL-D MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fq[mlEPTB;Mk[uNVcxQCEQvF2= MV;TRW5ITVJ?
NCI-H1436 M1XQWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlq0TWM2OD1{Nj6yO|M5KM7:TR?= MWXTRW5ITVJ?
COLO-824 M3TkOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HaSmlEPTB;Mk[uOFAxOiEQvF2= NFfmWJRUSU6JRWK=
CP50-MEL-B M2ruWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTJ4LkW2O|Uh|ryP M4XY[HNCVkeHUh?=
EGI-1 NWj4[|ViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nVcmlEPTB;MkeuNlY6QCEQvF2= NV7rbFJCW0GQR1XS
LAN-6 M2L3e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGe0dWxKSzVyPUK3MlM2QThizszN NYLVVZNjW0GQR1XS
GAK NGXIPVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHHZld4UUN3ME2yO{41OjJ3IN88US=> NYr1[2RvW0GQR1XS
MDA-MB-175-VII NV73TYE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jvV2lEPTB;MkeuOVA2OyEQvF2= M3XyUnNCVkeHUh?=
JVM-2 NH;qd|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;2WWxoUUN3ME2yO{43PjJ{IN88US=> MmqwV2FPT0WU
UACC-257 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFziUplKSzVyPUK3MlY5PzhizszN MoTPV2FPT0WU
SW1783 NX3LPYNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\ZTWM2OD1{Nz63O|g{KM7:TR?= MVXTRW5ITVJ?
HT-3 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;rTWM2OD1{OD6yNVY3KM7:TR?= NGK0VGtUSU6JRWK=
RL MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XQbWlEPTB;MkiuOVkyOSEQvF2= NH6y[ppUSU6JRWK=
TK10 NWTMS|VpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTJ6Lk[1N|Uh|ryP NVqyR3FLW0GQR1XS
HT55 M3n2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrMdmNKSzVyPUK5MlA2PjVizszN MYLTRW5ITVJ?
BT-20 M3vYR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzVTWM2OD1{OT6wOVg3KM7:TR?= M4S4bnNCVkeHUh?=
TGBC24TKB MlKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7XZ3N{UUN3ME2yPU4yQDNzIN88US=> M37n[nNCVkeHUh?=
HSC-2 M2jpPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHH6R3FKSzVyPUK5MlMxODFizszN NH\vXmNUSU6JRWK=
COLO-205 M17zSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHqTWM2OD1{OT6zPVQ1KM7:TR?= MkHOV2FPT0WU
GT3TKB NYP4T5FIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPLb2dKSzVyPUK5MlY5PzdizszN NIXoemNUSU6JRWK=
T47D M4XPSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTJ7Lki1PFIh|ryP NFHFbYtUSU6JRWK=
OMC-1 M4nRNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljETWM2OD1|MD6xPVE6KM7:TR?= MoTOV2FPT0WU
PFSK-1 M2XhRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTNzLkK2OVkh|ryP M2LPdXNCVkeHUh?=
JEG-3 Ml;yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTNzLkO1OlEh|ryP MVjTRW5ITVJ?
RD MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\HPG5WUUN3ME2zNU42OTF3IN88US=> MYXTRW5ITVJ?
NCI-H64 M1TO[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjpcHNKSzVyPUOyMlQyPzlizszN M2\pZnNCVkeHUh?=
DMS-114 MnTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXGcW9UUUN3ME2zNk41OTh{IN88US=> MnfuV2FPT0WU
NCI-H661 NHqzTVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvoWJJ2UUN3ME2zNk43PTBzIN88US=> M2PoU3NCVkeHUh?=
CAL-148 M3\lPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLROmhHUUN3ME2zNk43PjZ3IN88US=> MlXKV2FPT0WU
HuP-T3 NYPsRmZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TBe2lEPTB;M{KuPVM{QCEQvF2= NFToWnFUSU6JRWK=
ES4 NWSzbXVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVP4PYtJUUN3ME2zN{4yPzB3IN88US=> M1vWUnNCVkeHUh?=
Ca9-22 MnTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXGfWFvUUN3ME2zN{41PjBzIN88US=> NFzhbpRUSU6JRWK=
LP-1 NVPoN4hTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXOSFJKUUN3ME2zOE4xQSEQvF2= MlfiV2FPT0WU
AU565 M3HheWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XKcGlEPTB;M{SuOVA3QSEQvF2= M3rXTHNCVkeHUh?=
MDA-MB-453 MmD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonQTWM2OD1|NT6xOFI3KM7:TR?= MoTJV2FPT0WU
SNU-C1 MmXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fkPWlEPTB;M{WuNVcyKM7:TR?= MkDRV2FPT0WU
SW13 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NESxW41KSzVyPUO1MlQxPzZizszN Moi3V2FPT0WU
NCI-H2122 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTN3LkW1PVgh|ryP NELFZ|lUSU6JRWK=
NCI-H1395 M2nDPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDUcohjUUN3ME2zOU43PjlzIN88US=> M4PM[HNCVkeHUh?=
J-RT3-T3-5 NEPyOGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTN4LkCyPVQh|ryP MmXvV2FPT0WU
COR-L279 NELuXXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLNPWY2UUN3ME2zOk4yQThzIN88US=> MYXTRW5ITVJ?
ATN-1 NYfZNox3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3q2[GlEPTB;M{[uPFUyPiEQvF2= NHL1[JRUSU6JRWK=
HCC2998 Mnq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M134TmlEPTB;M{[uPFU4OSEQvF2= NVfHWpV7W0GQR1XS
UM-UC-3 NYK0OWRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHTTWM2OD1|Nj64Olc2KM7:TR?= MUHTRW5ITVJ?
DV-90 M2jiUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDyTWM2OD1|Nj65NFY4KM7:TR?= MmfCV2FPT0WU
ES8 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTN4LkmzNVgh|ryP NXPkRZN5W0GQR1XS
YAPC M3TNRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmflTWM2OD1|Nj65OlU1KM7:TR?= MmjKV2FPT0WU
HCC1599 M33wTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\4N3dKSzVyPUO3MlE3OThizszN NE\WdJpUSU6JRWK=
UMC-11 NF\uN|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPWTWM2OD1|Nz6yOVA{KM7:TR?= MXXTRW5ITVJ?
THP-1 NIX1T|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rzWWlEPTB;M{euNlg3QCEQvF2= MX;TRW5ITVJ?
OCUB-M MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnqd4xKSzVyPUO3MlI5QTFizszN Ml;MV2FPT0WU
NCI-H1693 NYLiUIpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzaOmdKSzVyPUO3MlMzOzNizszN MmPXV2FPT0WU
NCI-H345 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnUWVZNUUN3ME2zO{4{PjJ2IN88US=> M3fPUHNCVkeHUh?=
COLO-800 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIX5RYZKSzVyPUO3MlU3PyEQvF2= MVfTRW5ITVJ?
COLO-320-HSR MnOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NISwRYZKSzVyPUO4MlM1QTJizszN MX;TRW5ITVJ?
NCI-H596 Ml\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnGc|JKUUN3ME2zPE41PDh7IN88US=> M3npUnNCVkeHUh?=
NCI-H187 M2XBU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXXNlBCUUN3ME2zPE44OzR2IN88US=> MVXTRW5ITVJ?
ECC4 MmPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37yWGlEPTB;M{muNFgyPCEQvF2= NGTLXXNUSU6JRWK=
KP-4 NX7uOWJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjaTWM2OD1|OT6xNlM2KM7:TR?= Ml3hV2FPT0WU
NCI-H2227 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\Cc4VKSzVyPUO5MlM6PDlizszN MWXTRW5ITVJ?
22RV1 NHfpb|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTN7LkizPVgh|ryP MW\TRW5ITVJ?
SAS M{ntT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfmTWM2OD12MD6wPVYh|ryP M2W2VXNCVkeHUh?=
PANC-10-05 NH2wTppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjITWM2OD12MD6xPFI5KM7:TR?= NWDIXppYW0GQR1XS
MDA-MB-468 MkTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;zZnZKSzVyPUSwMlU{PDZizszN MnPsV2FPT0WU
RPMI-7951 NGXvSVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVu2VlRRUUN3ME20NU4zODd3IN88US=> MV\TRW5ITVJ?
BB49-HNC MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTRzLkKxO|kh|ryP NXT3SYJCW0GQR1XS
23132-87 M4jN[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvZflJKSzVyPUSxMlI4OzJizszN MlrWV2FPT0WU
HCC1569 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXVTWM2OD12MT6yPFg2KM7:TR?= NUX6ZmtJW0GQR1XS
CP66-MEL NWHyWXhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTRTWM2OD12Mj6xPFg3KM7:TR?= MljmV2FPT0WU
K-562 M1nEUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHG4OmFKSzVyPUSyMlI5PTRizszN M2D1NnNCVkeHUh?=
OCI-AML2 NF\4S2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\vb2lEPTB;NEKuPFk4PCEQvF2= NYC4bG85W0GQR1XS
SW756 NGjVSYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfjb3FKSzVyPUSzMlA{QDhizszN MnHlV2FPT0WU
M14 NEHCfpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17ZWWlEPTB;NEOuN|E5QSEQvF2= MY\TRW5ITVJ?
NCI-H1623 M3;L[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfrTWM2OD12Mz60OlQh|ryP MmHEV2FPT0WU
KNS-81-FD NETjcHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFO4PGFKSzVyPUSzMlc3OiEQvF2= MoXSV2FPT0WU
TGBC1TKB NFPSZoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTR|LkmwPVkh|ryP MYnTRW5ITVJ?
RERF-LC-MS MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\tWGlEPTB;NEOuPVI5OSEQvF2= NV7NR25MW0GQR1XS
PC-3 NUnUZYRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFH4bHFKSzVyPUS0MlQ{PDdizszN MWTTRW5ITVJ?
HuP-T4 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHFZ4NpUUN3ME20OE41PDd2IN88US=> NI\RU|BUSU6JRWK=
NCI-H510A NHnMUItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTR2LkewPEDPxE1? NGe0[JpUSU6JRWK=
LB2518-MEL MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTR2Lke5N|ch|ryP NY\jZ3h7W0GQR1XS
TE-5 NETY[3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHYSpdKSzVyPUS1Mlk2QDFizszN MlXJV2FPT0WU
EW-24 NXfG[XZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTR4LkG3NlMh|ryP M{\ze3NCVkeHUh?=
LB647-SCLC MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPYdYhpUUN3ME20Ok4zOTV3IN88US=> MV;TRW5ITVJ?
NCI-H524 NVHOWVk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTR4LkexPFUh|ryP Mlj1V2FPT0WU
EW-11 MnrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLHTWM2OD12Nj65N|c{KM7:TR?= NGjqOGdUSU6JRWK=
KALS-1 MoS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrlUoMxUUN3ME20O{4zODZ4IN88US=> MYfTRW5ITVJ?
BT-474 NIOy[nhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTR5LkSyNVYh|ryP NFviNplUSU6JRWK=
SK-N-AS Ml;ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTR5Lki4PEDPxE1? MoqzV2FPT0WU
HCC2157 NXvw[VR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1:0fWlEPTB;NEiuNFc3KM7:TR?= M1f0THNCVkeHUh?=
HCC1954 NUfYeJdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTYTWM2OD12OD6xO|A1KM7:TR?= MkjEV2FPT0WU
FADU MmrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTR6LkOwN|Eh|ryP M1rGT3NCVkeHUh?=
S-117 NXjCd4RsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPCUo9mUUN3ME20PE4{QDF3IN88US=> MX3TRW5ITVJ?
LS-1034 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTR6LkewOlch|ryP MUfTRW5ITVJ?
CAMA-1 M3f0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fteGlEPTB;NEmuOVU1OyEQvF2= NVvRVJhJW0GQR1XS
LU-134-A Ml\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DsV2lEPTB;NEmuPFA5PSEQvF2= NFfuWnNUSU6JRWK=
NCI-H1838 NHG3d5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2j2dWlEPTB;NEmuPFA5PyEQvF2= NHezUlJUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pSrc / Src / pPlcg / Plcg / pStat5 / Stat5 ; 

PubMed: 22781593     


In (B) inhibition of Src, Plcg and Stat5 was seen in MLNAF cell lines treated with Ponatinib; ZNF112 expresses ZMYM2–FGFR1, CEP2A and CEP5A cells express CEP110–FGFR1 and BBC2 expresses BCR–FGFR1.

pFGFR1(pY20) / FGFR1; 

PubMed: 22781593     


Western blot analysis, using various antibodies specific for downstream targets of FGFR1, demonstrates that Ponatinib inhibits the activation of Plcg and Src as a result of inhibiting the FGFR1 fusion kinase in human KG1 cells. 

cleaved caspase-3 / cleaved caspase-7 / BAX / Bcl-2; 

PubMed: 30959969     


Western blot analysis of cleaved caspase-3, cleaved caspase-7, Bax, Bcl-2, and β-Tubulin (control) in treated cells.

p-Rb(S807/811) / Rb / CDK4 / CDK6 / Cyclin D1 / CDK2 / Cyclin E1; 

PubMed: 30959969     


Western blot analysis of Rb/p-Rb, CDK4, CDK6, Cyclin D1, CDK2, Cyclin E1, and β-Tubulin (control) in the SK-Hep-1 and SNU-423 cells treated with ponatinib. 

RAD51; 

PubMed: 30959969     


The effect of ponatinib on the concentration of Rad51 in SK-Hep-1 and SNU-423 cells.

p-MEK / MEK / p-ERK / ERK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Mek and Erk. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

c-Jun / p-JNK(T183/Y185) / JNK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of JNK and c-Jun. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-p38 MAPK / p38 MAPK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of p38. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-JAK2 / JAK2 / p-STAT3 / STAT3; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Jak2, and Stat3. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

PI3K p85 / p-PI3K / p-PDK1 / PDK1 / p-mTOR / mTOR; 

PubMed: 30959969     


Effects of ponatinib on the protein concentration and phosphorylation of PI 3-kinase, PDK1, Akt, and mTOR in HCC cells. 

p-PDGFRα / PDGFRα; 

PubMed: 24472312     


Ponatinib inhibited phosphorylation of PDGFRα in a concentration-dependent manner. EOL-1 and BaF3-WT or -T674I FIP1L1-PDGFRα cells were exposed to escalating concentrations of ponatinib for 24 h.

PARP / Caspase-3 / Active Caspase-3; 

PubMed: 24472312     


The concentration- (for 24 h) and time-dependent (1 nM for EOL-1, 300 nM for BaF3-WT and -T674I FIP1L1-PDGFRα cells) cleavage of PARP and caspase-3 triggered by ponatinib was analyzed by immunoblotting.

AIF / Cyto C ; 

PubMed: 24472312     


Ponatinib elicited release of AIF and cytochrome c into the cytosol. Cells were treated with 1 nM ponatinib for the indicated durations and the cytosolic fraction was extracted with digitonin buffer. Levels of AIF and Cytochrome c (Cyto c) were detected by immunoblotting.

Mcl-1 / Survivin / Bcl-Xl / XIAP / Bax / Bcl-2 / Bim; 

PubMed: 24472312     


Immunoblotting of apoptosis-related proteins in CEL cells after treatment for 24 h.

β-catenin ; 

PubMed: 24472312     


Ponatinib concentration-dependently lowered β-catenin. EOL-1 cells were incubated with ponatinib for 24 h, and cytoplasmic and nuclear extracts were determined by immunoblotting.

β-catenin; 

PubMed: 24472312     


Analysis of β-catenin localization. EOL-1 cells were pretreated with 1 nM ponatinib for 24 h, immunofluorescence analysis was performed with anti-β-catenin. Nuclei were stained with 4,6-diamidino-2-phenylindole (DAPI). 

ABL; 

PubMed: 19878872     


In vitro [γ-32P]-ATP autophosphorylation of full-length (A) ABL or (B) ABLT315I kinase treated with AP24534, imatinib, nilotinib, or dasatinib. After incubation of tyrosine-dephosphorylated enzyme with the indicated inhibitor in the presence of [γ-32P]-ATP and separation by SDS-PAGE, signal intensity was measured by autoradiography.

22781593 30959969 24472312 19878872
Growth inhibition assay
Cell viability; 

PubMed: 30174789     


(A) Effect of Ponatinib on basal viability of HUVECs. The cells were treated with Ponatinib at indicated concentrations or 0.1% DMSO (vehicle control) for 24 h.

30174789
体内研究 Ponatinib抑制取自FLT3-ITD阳性AML病人的原代白血病细胞,而不抑制表达阴性FLT3的AML病人的白血病细胞。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
- 合并

激酶实验:

通过同质时间分辨荧光共振能量转移法(TR-FRET),使用纯化的人类野生型ABL激酶,T315I突变型ABL激酶,及生物素化的磷酸激酶底物肽: 生物素-EKKMAAEAIYAAPFAK-NH2,测定野生型ABL和T315I突变型ABL活性的抑制激酶反应在全LANCE激酶buffer (LKB)中进行,LKB包括20 mM NaHEPES(pH 为7.4), 0.1 mg ⁄ mL BSA, 1 mM ATP, 10 mM MgCl2, 及0.41 mM DTT,在提前用1% BSA(溶于PBS)包被的96孔板上4oC下过夜。用于激酶反应,Ponatinib稀释物和野生型ABL, T315I突变型ABL (40 pM), 及底物肽(50 nM), 在室温下温育1小时(T315I突变型ABL)或2小时(野生型ABL)。加入15 nM 抑制剂, 6 nM 铕标记的磷酸酪氨酸抗体(磷酸化位点在第66为酪氨酸上),及60 nM 别藻蓝素标记的链酶亲和素,终止反应。实验板在室温下黑暗温育20分钟,使用Wallac Victor2V读数器读取615和665nm处的荧光值。在孔中数据平均值中插入抑制剂的3倍连续稀释液,再读取665nm处荧光值,计算IC50值。
细胞实验:[1]
- 合并
  • Cell lines: Ba ⁄ F3细胞
  • Concentrations: 0-625 nM, 和0-10 µM
  • Incubation Time: 72小时
  • Method: Ba/F3细胞系按每孔4×103个细胞分布在96孔板上(4×103),和梯度浓度Ponatinib温育72小时。Ponatinib浓度范围为: 0-625 nM 作用于表达BCR-ABL细胞,0-10 µM 用于测定BCR-ABL阴性细胞。使用MTS实验测定细胞增殖,取三次平行实验平均值测定IC50值。
    (Only for Reference)
动物实验:[3]
- 合并
  • Animal Models: 皮下植入MV4-11细胞移植瘤(1×107,50%基质胶中) 的雌性CB.17 SCID鼠
  • Dosages: 每天处理一次,持续4周
  • Administration: 口服饲喂处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
1% CMC Na
30mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 532.56
化学式

C29H27F3N6O

CAS号 943319-70-8
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04160546 Recruiting Drug: Ponatinib 15 MG|Drug: Acetylsalicylic acid 100 MG Chronic Myeloid Leukemia Chronic Phase Fundacion CRIS de Investigación para Vencer el Cáncer|Incyte Biosciences UK|Apices Soluciones S.L. January 17 2020 Phase 2
NCT04070443 Recruiting Drug: Ponatinib|Drug: Imatinib Philadelphia Chromosome Positive CML|BCR-ABL Positive Chronic Myelogenous Leukemia Centre Leon Berard November 13 2019 Phase 2
NCT03934372 Recruiting Drug: Ponatinib Acute Myeloid Leukemia|Accelerated Phase Chronic Myeloid Leukemia|Blast Phase Chronic Myeloid Leukemia|Chronic Phase Chronic Myeloid Leukemia|Acute Lymphoblastic Leukemia|Acute Lymphocytic Leukemia|Leukemia|Lymphoma|Solid Tumors Incyte Biosciences International Sàrl|Incyte Corporation November 22 2019 Phase 1|Phase 2
NCT03895671 Recruiting Drug: Ponatinib|Drug: Azacitidine CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE|CHRONIC MYELOGENOUS LEUKAEMIA IN MYELOID BLAST CRISIS Versailles Hospital June 19 2019 Phase 2
NCT03690115 Recruiting Drug: Ponatinib 30 MG Leukemia Myeloid Acute Versailles Hospital December 12 2018 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID