Ponatinib (AP24534)

目录号:S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534)是一种新型有效的多靶点抑制剂,在无细胞试验中作用于Abl,PDGFRα,VEGFR2,FGFR1和Src,IC50分别为0.37 nM,1.1 nM,1.5 nM,2.2 nM和5.4 nM。

规格 价格 库存 购买数量  
RMB 819.31 现货
RMB 903.01 现货
RMB 3034.48 现货
RMB 7959.08 现货
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客户使用该产品的4个实验数据:

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

产品描述 Ponatinib (AP24534)是一种新型有效的多靶点抑制剂,在无细胞试验中作用于Abl,PDGFRα,VEGFR2,FGFR1和Src,IC50分别为0.37 nM,1.1 nM,1.5 nM,2.2 nM和5.4 nM。
靶点
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外研究

Ponatinib是有效的可用于口服的多靶点激酶抑制剂,作用于野生型细胞,及T315I 突变细胞IC50分别为1.2和8.8nM。[1] Ponatinib抑制Ba/F3衍生细胞系的增殖。[2] Ponatinib作用于表达野生型或T315I突变型BCR-ABL的CML细胞系,有效抑制BCR-ABL调节的信号。Ponatinib阻断在细胞瘤筛选时产生抗性突变。[3] Ponatinib也抑制VEGFR和FGFR家族激酶,在体外抑制FLT3, KIT, FGFR1,和PDGFRa激酶活性时IC50分别为13, 13, 2, 和1 nM.[4]Ponatinib抑制全部4种RTKs磷酸化,存在剂量依赖性,IC50值为0.3到20 nM。然而,Ponatinib抑制表达野生型FLT3的RS4;11细胞时IC50>100 nM。

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell MnPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnG1TWM2OD1yLkCwNFAxODB|NUmg{txO MnP0V2FPT0WU
MV-4-11 NUTZSY17T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrhb5dVUUN3ME2wMlAxODB7NU[g{txO NUjwUpUyW0GQR1XS
MEG-01 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmG2TWM2OD1yLkCwNFEzQCEQvF2= MYTTRW5ITVJ?
LAMA-84 MlHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMECwNVY2KM7:TR?= M3fOeXNCVkeHUh?=
CGTH-W-1 MkTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDYTWM2OD1yLkCwNVY6KM7:TR?= Ml7tV2FPT0WU
KASUMI-1 NIfJVFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3mbHdPUUN3ME2wMlAxOjF5IN88US=> NYnCfGxGW0GQR1XS
BE-13 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPDPXhvUUN3ME2wMlAxOjV7IN88US=> Mn6zV2FPT0WU
CTV-1 NGn1TndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPMfpg5UUN3ME2wMlAxPTJzIN88US=> MX3TRW5ITVJ?
NKM-1 NITTOIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUWxT286UUN3ME2wMlAxPjV3IN88US=> NHu0eZhUSU6JRWK=
MONO-MAC-6 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnsTWM2OD1yLkCwPFM4KM7:TR?= Mli0V2FPT0WU
A204 M4rFS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMEGyNVgh|ryP MmTGV2FPT0WU
GDM-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PsbmlEPTB;MD6wNVg{OyEQvF2= MYTTRW5ITVJ?
AN3-CA M2XNemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7hPZhKSzVyPUCuNFE5PzNizszN M3rSO3NCVkeHUh?=
BL-70 M{TnZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;pW21WUUN3ME2wMlAzOTl7IN88US=> NXTQfox{W0GQR1XS
Daudi MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2L2b2lEPTB;MD6wNlU{PyEQvF2= NHfFbpdUSU6JRWK=
KU812 NXnHdIpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMEK4OFgh|ryP M2Lkc3NCVkeHUh?=
KG-1 NHyzRWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjWTWM2OD1yLkCzNlk1KM7:TR?= NFmyS4lUSU6JRWK=
DOHH-2 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHR[olKSzVyPUCuNFQ5ODNizszN NHfwVYtUSU6JRWK=
HuO9 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMEW0OFgh|ryP Mk\sV2FPT0WU
EB2 MoXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMEW1O|Yh|ryP NVjieXVmW0GQR1XS
G-402 NWnsfo56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPqSlQ2UUN3ME2wMlA3OzRzIN88US=> NXmxZXhbW0GQR1XS
SU-DHL-1 NXvVV4xkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{noXGlEPTB;MD6wOlM4QSEQvF2= M37LSHNCVkeHUh?=
NCI-H719 M4PJUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHiz[pRKSzVyPUCuNFc5QDhizszN NHrGRYZUSU6JRWK=
MLMA MkO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMEmwOkDPxE1? NFW3fYxUSU6JRWK=
KM12 NFrjRWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPBdXM5UUN3ME2wMlA6PzN5IN88US=> M2nTenNCVkeHUh?=
SUP-T1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMEm5PFIh|ryP MU\TRW5ITVJ?
MZ1-PC NF\jNoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DRd2lEPTB;MD6xNVM{PiEQvF2= NEnRTmJUSU6JRWK=
MFE-296 NIT1XVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDVR5ZFUUN3ME2wMlEyQDN7IN88US=> NV6xeotqW0GQR1XS
ALL-PO M1\VNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rodmlEPTB;MD6xNlQ1OyEQvF2= M4D6dHNCVkeHUh?=
GB-1 Mn7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnlbVlZUUN3ME2wMlEzPTF{IN88US=> MnGxV2FPT0WU
SIG-M5 NX3C[257T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPJUYVmUUN3ME2wMlE{OzdizszN M3rzeXNCVkeHUh?=
P30-OHK NUO0fYs{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfs[WxKSzVyPUCuNVU3PzJizszN NYTTZWMxW0GQR1XS
NCI-H716 NVzObotnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFn6W3dKSzVyPUCuNVYzPjZizszN M4DaXXNCVkeHUh?=
MPP-89 M2jnWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvqbIJKSzVyPUCuNVY6OzNizszN MmjCV2FPT0WU
SF126 NGC1OpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\DdXNKSzVyPUCuNVcxPjNizszN NHPPXYZUSU6JRWK=
CTB-1 NITQU|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmWxTWM2OD1yLkG3N|E3KM7:TR?= MYrTRW5ITVJ?
CA46 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn35TWM2OD1yLkG3OFg6KM7:TR?= M4LtN3NCVkeHUh?=
NCI-H520 NEPmWVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\SZmlEPTB;MD6xO|c{OiEQvF2= Mn;lV2FPT0WU
CAL-85-1 MmLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rQS2lEPTB;MD6xO|kzPyEQvF2= M{HXVnNCVkeHUh?=
NCI-H2342 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrZcFNKSzVyPUCuNVg2PzdizszN MlT3V2FPT0WU
697 M3W1Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml6zTWM2OD1yLkG4PFcyKM7:TR?= NH\MNY1USU6JRWK=
NY Mo\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HHbmlEPTB;MD6xPVI5PyEQvF2= NVqxb3g6W0GQR1XS
T98G MnrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;ucnFSUUN3ME2wMlE6OzF6IN88US=> MXPTRW5ITVJ?
NCI-H1703 MnPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnkTWM2OD1yLkG5OlE2KM7:TR?= MWjTRW5ITVJ?
NCI-H2087 NHPjbZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXvTWM2OD1yLkKwOFM6KM7:TR?= NUK5bld6W0GQR1XS
PF-382 M3\Jd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;H[mlEPTB;MD6yNFg4OyEQvF2= M2K0NXNCVkeHUh?=
HCT-116 NF3Ec4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\OTWM2OD1yLkKxNFY6KM7:TR?= MkizV2FPT0WU
CAKI-1 NWHqcGRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HH[2lEPTB;MD6yNVY3PiEQvF2= MV\TRW5ITVJ?
CCF-STTG1 MnzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwMkK0O|Uh|ryP NXrRVVVmW0GQR1XS
D-392MG MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUe3W5BuUUN3ME2wMlI{OTd5IN88US=> M4PpPXNCVkeHUh?=
RT-112 NY\QO21QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jqU2lEPTB;MD6yN|c6PSEQvF2= NIP2SohUSU6JRWK=
MES-SA M{HBNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:wTWM2OD1yLkK0NVg4KM7:TR?= NUTDeoQ1W0GQR1XS
LC-2-ad Mn3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDLdpJ4UUN3ME2wMlI1OjZ3IN88US=> MmHUV2FPT0WU
NOS-1 M2T6O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXf0NlNVUUN3ME2wMlI1OzZ5IN88US=> NFPyZ3FUSU6JRWK=
NALM-6 MmDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPnTWM2OD1yLkK1OVQ{KM7:TR?= NVnKSHhXW0GQR1XS
TE-15 M{TWdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDqSIN[UUN3ME2wMlI3ODlzIN88US=> NW\SXGVFW0GQR1XS
786-0 NWXM[45LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHlTWM2OD1yLkK2NlI5KM7:TR?= NW\zTHp1W0GQR1XS
IST-MES1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn3WmZIUUN3ME2wMlI3QDJ7IN88US=> M{fVcHNCVkeHUh?=
KYSE-180 Ml7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1uzZmlEPTB;MD6yOlg6OSEQvF2= NEH1dYdUSU6JRWK=
YT MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWq3V5I{UUN3ME2wMlI3QTd2IN88US=> MkDtV2FPT0WU
A427 NGHHSZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zCcmlEPTB;MD6yO|I3PCEQvF2= MlXvV2FPT0WU
KYSE-450 M4q1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMkezNlkh|ryP NILndXhUSU6JRWK=
HuH-7 M4\HcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXzTWM2OD1yLkK3O|Y{KM7:TR?= MoWyV2FPT0WU
CAS-1 MoPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk[xTWM2OD1yLkK4N|A{KM7:TR?= Mme0V2FPT0WU
KURAMOCHI MkH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmD3TWM2OD1yLkK4OFE6KM7:TR?= NUjzemdEW0GQR1XS
ACHN M1:xcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMkmzNlMh|ryP MknYV2FPT0WU
HGC-27 M{j4TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DNNGlEPTB;MD6yPVM2OyEQvF2= MlTwV2FPT0WU
A172 M1LTTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf5NVlKSzVyPUCuNlk2PzdizszN MUXTRW5ITVJ?
SNU-449 M4naemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMkm5OlQh|ryP M1vtRXNCVkeHUh?=
SW982 NGfESHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjKeXpIUUN3ME2wMlI6QTd6IN88US=> NUX2SWtQW0GQR1XS
EFO-21 M2HxRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVe5bppbUUN3ME2wMlMxPDFzIN88US=> NF23RmVUSU6JRWK=
NCI-H2030 NUjmNVV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjuO|BjUUN3ME2wMlMyOTZ2IN88US=> MkPTV2FPT0WU
HT-144 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWD5PZBEUUN3ME2wMlMyOjhizszN MUHTRW5ITVJ?
MFE-280 M3fjTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTjTWM2OD1yLkOxOFU{KM7:TR?= NWrQSYx5W0GQR1XS
SK-LU-1 Mlj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7kTWM2OD1yLkOxOFY3KM7:TR?= NWjMPHFlW0GQR1XS
NCI-H2052 NXvuTlBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jZRWlEPTB;MD6zNVQ5PCEQvF2= M2iwdXNCVkeHUh?=
SK-HEP-1 NXHNcpFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\kZWlEPTB;MD6zN|M3QCEQvF2= MWrTRW5ITVJ?
QIMR-WIL NF;LVXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwM{O0NlQh|ryP MkHIV2FPT0WU
A2780 M{DiRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nKZWlEPTB;MD6zOFMxPCEQvF2= NVL3NWQ3W0GQR1XS
ACN M3X3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTvTWM2OD1yLkO0PFc{KM7:TR?= MWjTRW5ITVJ?
BxPC-3 M{XtRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jhO2lEPTB;MD6zOFk5QSEQvF2= M3i5VXNCVkeHUh?=
BCPAP NUHQNIxwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\3ZoExUUN3ME2wMlM3ODBzIN88US=> MXnTRW5ITVJ?
HOP-62 MmHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvVcIpKSzVyPUCuN|YyODZizszN NIjtU4tUSU6JRWK=
SW1710 M3\qRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPzTVZKSzVyPUCuN|Y1PTVizszN NIe0dlhUSU6JRWK=
OPM-2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwM{[0O|Mh|ryP MlnrV2FPT0WU
DBTRG-05MG NIrwUoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLmOY9GUUN3ME2wMlM5ODV2IN88US=> MlPrV2FPT0WU
SK-MEL-24 M3TMdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjEemJKSzVyPUCuN|k4QTFizszN MWnTRW5ITVJ?
8305C MlXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrwTWM2OD1yLkO5O|k{KM7:TR?= NYXPe2hmW0GQR1XS
OVCAR-4 MmnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\vOnoyUUN3ME2wMlQyPTh4IN88US=> M33qXHNCVkeHUh?=
HLE NIDCSI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\MdHh6UUN3ME2wMlQyQDZizszN NVf6PIh7W0GQR1XS
NCI-H747 Moj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPtTWM2OD1yLkSyNVM4KM7:TR?= M4\hfnNCVkeHUh?=
SW780 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LqcGlEPTB;MD60NlM1PiEQvF2= NXPMc3p5W0GQR1XS
KYSE-150 NUjlbGV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwNEK0NVUh|ryP NY\xTXlvW0GQR1XS
H4 NGPweZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwNEK0OVEh|ryP NUiyc2xQW0GQR1XS
SW1088 NUHkVplpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Ti[2lEPTB;MD60OFM6KM7:TR?= NWDzUGF2W0GQR1XS
SF268 M3rVcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn1TWM2OD1yLkS0PFYh|ryP NUfSUllPW0GQR1XS
RT4 MofxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3v5fmlEPTB;MD60OVEyOSEQvF2= NV\IOWVqW0GQR1XS
NCI-H522 M1PvUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETKXIVKSzVyPUCuOFUzPyEQvF2= Mny3V2FPT0WU
LCLC-97TM1 M1\tdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvy[WlZUUN3ME2wMlQ3OTl3IN88US=> MY\TRW5ITVJ?
CAL-39 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXVTWM2OD1yLkS2OVE6KM7:TR?= M37lcnNCVkeHUh?=
CAL-120 M4XBN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3lWIVmUUN3ME2wMlQ4PjR|IN88US=> Mk\1V2FPT0WU
ESS-1 NHmyVXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXjblFrUUN3ME2wMlQ4QDJzIN88US=> M3SxVXNCVkeHUh?=
KARPAS-45 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjCdmxbUUN3ME2wMlQ5QTN|IN88US=> M4TGXnNCVkeHUh?=
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KNS-42 NYfaW49YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\nN4pKSzVyPUGuPFYzPjZizszN NGDiO2hUSU6JRWK=
NCI-H2452 NGWxSHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTpcpcxUUN3ME2xMlg6ODd2IN88US=> MV7TRW5ITVJ?
SK-MEL-2 NXvu[olbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTFwOUCyO|Eh|ryP M3HNNnNCVkeHUh?=
OVCAR-5 NFzIcZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfCfYRKSzVyPUGuPVA3PzVizszN M3fh[XNCVkeHUh?=
SNG-M M1[1Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1uwOWlEPTB;MT65OVg2QCEQvF2= Ml\3V2FPT0WU
A673 NWPTNoRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTjOm9KUUN3ME2xMlk4PTF4IN88US=> M3;ER3NCVkeHUh?=
L-428 M3H5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojFTWM2OD1zLkm5NVc6KM7:TR?= NVTpeWp5W0GQR1XS
KM-H2 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LK[WlEPTB;Mj6wNVA6KM7:TR?= MWHTRW5ITVJ?
MC-IXC M1TSc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETpXXlKSzVyPUKuNFIzPzNizszN NYHwc5BQW0GQR1XS
COLO-678 M2jlbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPsN3UzUUN3ME2yMlA1OjB5IN88US=> NYrFdWJFW0GQR1XS
MEL-JUSO MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJwMEe4OVEh|ryP NHTuO21USU6JRWK=
HCC38 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVn3VYJMUUN3ME2yMlA5PDN|IN88US=> M17KcHNCVkeHUh?=
UACC-62 M3fM[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnFSpU4UUN3ME2yMlA5QDV3IN88US=> NVOyemlvW0GQR1XS
OAW-42 MoPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTJwMEm3NVEh|ryP M3vLTHNCVkeHUh?=
LB996-RCC NHXreWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XYe2lEPTB;Mj6xN|gyPyEQvF2= M4OwbXNCVkeHUh?=
COR-L105 NUfLemZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvPXVVNUUN3ME2yMlE3Ozd|IN88US=> MWHTRW5ITVJ?
RCC10RGB MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvtTWM2OD1{LkG4OVc3KM7:TR?= MUfTRW5ITVJ?
A431 M3;TWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjlTWM2OD1{LkG5NFE6KM7:TR?= NInuN5NUSU6JRWK=
NCI-H292 M2PiWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHMTWM2OD1{LkKzPVUyKM7:TR?= NEXyOoNUSU6JRWK=
SK-UT-1 NYfSbIljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPodlV6UUN3ME2yMlM{OTh2IN88US=> NVqybod2W0GQR1XS
PANC-08-13 NHOxVllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\XTWM2OD1{LkOzNlM2KM7:TR?= MYTTRW5ITVJ?
ST486 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIH1VmtKSzVyPUKuOFExPDhizszN MWLTRW5ITVJ?
SJSA-1 MlW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTJwNEGyO|Eh|ryP NHH4V2lUSU6JRWK=
RKO M{XPfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7aTWM2OD1{LkSyNFI6KM7:TR?= Mn7kV2FPT0WU
NCI-H1793 NW\KS|VyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PUVGlEPTB;Mj60OFAzQSEQvF2= MkHGV2FPT0WU
639-V NH3aPJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jqVWlEPTB;Mj60OVM5OiEQvF2= MUDTRW5ITVJ?
ES3 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXr0fVZrUUN3ME2yMlQ6PzN5IN88US=> MX3TRW5ITVJ?
NCI-H1792 Mnm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTJwNU[4NlYh|ryP M4rIUnNCVkeHUh?=
NCI-H1651 M1vnR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPTVJBKSzVyPUKuOVgzOSEQvF2= NE\RZ4ZUSU6JRWK=
SN12C M4TCS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;lSmlEPTB;Mj61PFQ5PyEQvF2= NHzuTlFUSU6JRWK=
COLO-679 M3fz[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLXTWM2OD1{LkW4OlA2KM7:TR?= NHq3cIJUSU6JRWK=
U-118-MG M2PaeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvzWYNKSzVyPUKuOVg5PzJizszN M3T2RnNCVkeHUh?=
Ramos-2G6-4C10 MoLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLQTWM2OD1{Lk[0PFA4KM7:TR?= NXXtd4VuW0GQR1XS
HCT-15 MlLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlz3TWM2OD1{Lk[4O|kzKM7:TR?= NXXhfHlLW0GQR1XS
MDA-MB-157 NV71ZW9DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHDTWM2OD1{LkewO|Q4KM7:TR?= M3fqZnNCVkeHUh?=
K5 NWLJfXRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTJwN{G4OFUh|ryP M3\1dHNCVkeHUh?=
MKN45 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:3TWM2OD1{LkezN|Y3KM7:TR?= MUjTRW5ITVJ?
DMS-273 MnS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTJwN{W2N|Ih|ryP M4rHVXNCVkeHUh?=
C8166 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HJ[mlEPTB;Mj63PFUyOyEQvF2= M1PyWHNCVkeHUh?=
Calu-3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHKTWM2OD1{Lke4PVY6KM7:TR?= MlPWV2FPT0WU
SNB75 M2ja[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTUOm1KSzVyPUKuPFg2OzVizszN NXn3eWtNW0GQR1XS
BFTC-905 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPyTWM2OD1{LkmwNVkyKM7:TR?= NFfYWVZUSU6JRWK=
C-4-II MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILHSpdKSzVyPUKuPVE{PTNizszN MmPKV2FPT0WU
MS-1 Mmn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLiemtkUUN3ME2yMlk3PzZ7IN88US=> Mnr5V2FPT0WU
A375 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTNwMEixPFQh|ryP M4PXc3NCVkeHUh?=
KYSE-70 NFm1bFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrhUI0{UUN3ME2zMlA5QDh{IN88US=> M1T6cHNCVkeHUh?=
KYSE-510 M1yzUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nIVWlEPTB;Mz6xNFk6PSEQvF2= NGHRN2RUSU6JRWK=
LN-405 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfQU5RYUUN3ME2zMlE{PTF6IN88US=> MYfTRW5ITVJ?
BOKU MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fXPWlEPTB;Mz6xOFI2PiEQvF2= NIHsdoZUSU6JRWK=
TE-10 NGm1eZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTNwMUezOlIh|ryP M{\kXHNCVkeHUh?=
MKN1 NHK1dndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTNwMUi0PFMh|ryP NE\RSGtUSU6JRWK=
M059J NX\IPGRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTNwMkCxO|Mh|ryP MoewV2FPT0WU
GOTO NYTJOIxkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnRXVRKSzVyPUOuNlIxOzlizszN NXjse2hUW0GQR1XS
DK-MG NWnpSVRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PxTWlEPTB;Mz6yOVk4PiEQvF2= M3fiUnNCVkeHUh?=
NCI-H727 NX;ie|RXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XHdWlEPTB;Mz6yOlU5KM7:TR?= NWX4PYFwW0GQR1XS
NB12 NIrJelBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTNwM{OyNlQh|ryP MmDnV2FPT0WU
DOK NHm1XGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1v4cWlEPTB;Mz6zOlE5PiEQvF2= MUfTRW5ITVJ?
KYSE-410 NVHwcHRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTNwM{[yPFch|ryP NU\vdW9XW0GQR1XS
AM-38 Mm[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlX1TWM2OD1|LkO4NFUyKM7:TR?= NWLRdXlsW0GQR1XS
GR-ST M1vPc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLTTWM2OD1|LkS1O|MzKM7:TR?= MYLTRW5ITVJ?
D-247MG M3rpZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfUTWM2OD1|LkS4NlY{KM7:TR?= NX23fmtMW0GQR1XS
TE-8 NXnEVYpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrCTXVDUUN3ME2zMlQ6OzN|IN88US=> NW\jfphKW0GQR1XS
LS-411N NIPTW4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjrSGdKSzVyPUOuOFk3QTJizszN M365Z3NCVkeHUh?=
SK-MES-1 NGrjbWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTNwNU[0N|Mh|ryP NUHNVVF6W0GQR1XS
SF295 NIfi[FJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\rdIpKSzVyPUOuOlE2PTJizszN M1nwXHNCVkeHUh?=
SK-MEL-30 M{fJc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{n1SWlEPTB;Mz62OVkzOSEQvF2= NEnpNmtUSU6JRWK=
LB2241-RCC M{nzemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfuTWM2OD1|Lk[2NlYh|ryP Mn\HV2FPT0WU
PC-14 NWPEOYV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDj[lVKSzVyPUOuOlY1OzdizszN MX;TRW5ITVJ?
EW-7 NFTZS2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTNwNke2PVMh|ryP MnXSV2FPT0WU
NMC-G1 NYjTcodTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\yWXE1UUN3ME2zMlcyQDN5IN88US=> NGLwb|BUSU6JRWK=
TE-441-T NXjCdlk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrwTWM2OD1|LkezNFI5KM7:TR?= MWHTRW5ITVJ?
NCI-H1618 NGjZWW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnteZVKSzVyPUOuPFE5PzVizszN M{TnbnNCVkeHUh?=
PANC-03-27 NIS0V4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETWOo9KSzVyPUOuPFE6OTZizszN NX7mRnM2W0GQR1XS
NCI-H2228 NH33V5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfPTWM2OD1|LkizNVI3KM7:TR?= MkDBV2FPT0WU
CAPAN-1 NX;qcVl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIe2[IVKSzVyPUOuPFcxODlizszN MoDmV2FPT0WU
KLE Ml3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXH0clFCUUN3ME2zMlkxPjdizszN NWize4VRW0GQR1XS
Becker MlrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjnbo1KSzVyPUOuPVI5PDlizszN NIT5S5pUSU6JRWK=
SK-PN-DW MnvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTRwMEe5O|Qh|ryP Mkf0V2FPT0WU
Hs-578-T NULvcHdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4O0SmlEPTB;ND6wPFMxPiEQvF2= MXzTRW5ITVJ?
RS4-11 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTaTWM2OD12LkGxNlU2KM7:TR?= Ml\QV2FPT0WU
D-502MG NGD2XYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTRwMU[5PVch|ryP M{LKUnNCVkeHUh?=
GI-1 MnT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;q[GlEPTB;ND6yPFI6QSEQvF2= MXjTRW5ITVJ?
NCI-H209 NUHsOJFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnFb5pKSzVyPUSuN|M4QCEQvF2= NV\KeXI5W0GQR1XS
SK-OV-3 NHrCUY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnVR41KSzVyPUSuOFgyPDlizszN MnHJV2FPT0WU
LOUCY M3XufGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHjT|NKSzVyPUSuOFg1OzJizszN M{O2O3NCVkeHUh?=
NCI-H69 NEfRRZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmm4TWM2OD12LkWxO|k{KM7:TR?= MoLjV2FPT0WU
SCC-9 NUfyN2hUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITqdIhKSzVyPUSuOVMyPzJizszN MYTTRW5ITVJ?
NCI-H526 MlG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfOfpNKSzVyPUSuOVkzQTNizszN MUXTRW5ITVJ?
NCI-H2170 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTRwNk[3O|Eh|ryP NELJcY1USU6JRWK=
SR MmXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXDfIlKSzVyPUSuO|AxPDhizszN MnztV2FPT0WU
CMK MnO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTRwN{KxNFEh|ryP MXvTRW5ITVJ?
COLO-829 MnzCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2mwXWlEPTB;ND63O|A1OyEQvF2= NHnoO|BUSU6JRWK=
HuO-3N1 Mn[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrZ[YZ2UUN3ME20Mlg{OjhzIN88US=> NVrLSGdSW0GQR1XS
5637 NFfhZ4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHK4R|BKSzVyPUSuPVA1QDdizszN MUjTRW5ITVJ?
A253 M1;vdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTRwOUe3NFgh|ryP M3n6fHNCVkeHUh?=
NB10 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3QPIlDUUN3ME21MlA4PDl5IN88US=> NHr5TZJUSU6JRWK=
SF539 MnfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTVwMEm5OVkh|ryP NXrqW4NmW0GQR1XS
HAL-01 NWfCNIdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TtPGlEPTB;NT6xOFY1PSEQvF2= NUDlNmJLW0GQR1XS
MHH-ES-1 NVv1d3Z1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXr3VndpUUN3ME21MlE3QTJ3IN88US=> NYrwXldwW0GQR1XS
DEL MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HOV2lEPTB;NT6yO|U5OiEQvF2= NUjRR4syW0GQR1XS
NCI-H1299 NXnxRWFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLNTWM2OD13LkO1NFA4KM7:TR?= NFL3VJBUSU6JRWK=
ChaGo-K-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHzTWM2OD13LkO1NVA4KM7:TR?= MWfTRW5ITVJ?
HMV-II MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTVwM{m0N{DPxE1? MYHTRW5ITVJ?
NB69 NISyNm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvHTWM2OD13LkO5OlMyKM7:TR?= NIKyRWNUSU6JRWK=
NCI-H1882 NXrq[pJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknLTWM2OD13LkSzN|Y1KM7:TR?= NWDq[ZY{W0GQR1XS
SNU-475 NEnYc|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;t[YxKSzVyPUWuOFcyPzFizszN MkjTV2FPT0WU
RXF393 MoTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfwS|ZCUUN3ME21MlQ5PDl2IN88US=> NIXIPVRUSU6JRWK=
CAL-51 MnHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXuRolDUUN3ME21MlYzQDV|IN88US=> MXnTRW5ITVJ?
SW1573 Mni1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTVwNkO1N|Qh|ryP MXnTRW5ITVJ?
GCT MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vsRmlEPTB;NT63OVkzQSEQvF2= NHLaNoVUSU6JRWK=
COR-L88 MlvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[1bZVZUUN3ME21Mlc3QDR4IN88US=> M3\IT3NCVkeHUh?=
MDA-MB-134-VI M3vqRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DoZWlEPTB;NT64O|U{PiEQvF2= M3HJfXNCVkeHUh?=
NB5 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvpTWM2OD13LkmyOFQh|ryP MVTTRW5ITVJ?
GMS-10 NIm1Z49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXlSHhWUUN3ME21Mlk3QDZzIN88US=> NHfiO4RUSU6JRWK=
CHP-212 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{WwO2lEPTB;Nj60PFI3PyEQvF2= NGXvT5BUSU6JRWK=
TE-11 Ml7iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnLNYpKSzVyPU[uOVUyQDJizszN NVP3N4xJW0GQR1XS
SW962 NVXGd5RST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Ple2lEPTB;Nj62OVc4PCEQvF2= MWLTRW5ITVJ?
MZ2-MEL NVLibYJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTZwOEKwNVEh|ryP MY\TRW5ITVJ?
C-33-A NHfyUmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVH3VIdXUUN3ME22MlkyPjh6IN88US=> M1PmOnNCVkeHUh?=
IGR-1 MlHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTZwOUe4NlYh|ryP NVvJbXA1W0GQR1XS
MOLT-4 MkPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvMTWM2OD15LkG1OFA3KM7:TR?= Mof4V2FPT0WU
NCI-H1650 M3nyRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LGfGlEPTB;Nz6yO|A1PiEQvF2= NITweWxUSU6JRWK=
AsPC-1 M3P6Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFz4TW1KSzVyPUeuNlg3ODVizszN M3TI[nNCVkeHUh?=
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CAL-62 NHnGcZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIL4S4NKSzVyPUKyMlc2OTdizszN NHjvOGpUSU6JRWK=
HCE-T NUTmZVZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fhb2lEPTB;MkKuPFYxPiEQvF2= NVPn[nBjW0GQR1XS
BB65-RCC Mkm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLyTWM2OD1{Mz6wN|Q1KM7:TR?= M2H0OHNCVkeHUh?=
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PA-1 NF3M[3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYe5Z2IxUUN3ME2yOU43QDN|IN88US=> MWjTRW5ITVJ?
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RL MlWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTJ6LkW5NVEh|ryP MXHTRW5ITVJ?
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COLO-205 M{TaOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjsTFI5UUN3ME2yPU4{QTR2IN88US=> NVj2[4JYW0GQR1XS
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AU565 NGjYNZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWX4R4k2UUN3ME2zOE42ODZ7IN88US=> MlXPV2FPT0WU
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THP-1 NVrCfnpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYj3S|FOUUN3ME2zO{4zQDZ6IN88US=> NWPLZlVOW0GQR1XS
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NCI-H345 NVvBbY1UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXX6N4p5UUN3ME2zO{4{PjJ2IN88US=> MnKyV2FPT0WU
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ECC4 NFjFRVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7VSJJpUUN3ME2zPU4xQDF2IN88US=> NXzxXFV1W0GQR1XS
KP-4 M1;Ge2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LZUGlEPTB;M{muNVI{PSEQvF2= NFrIXm9USU6JRWK=
NCI-H2227 M4XkXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHr5S4VKSzVyPUO5MlM6PDlizszN NULR[nhqW0GQR1XS
22RV1 Ml7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW[y[WJPUUN3ME2zPU45Ozl6IN88US=> MXPTRW5ITVJ?
SAS MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTRyLkC5OkDPxE1? MX;TRW5ITVJ?
PANC-10-05 MkHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3mzXWlEPTB;NECuNVgzQCEQvF2= MVzTRW5ITVJ?
MDA-MB-468 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTRyLkWzOFYh|ryP NF7pOoJUSU6JRWK=
RPMI-7951 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;CXZFKSzVyPUSxMlIxPzVizszN NYnBO|dMW0GQR1XS
BB49-HNC MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1v6dGlEPTB;NEGuNlE4QSEQvF2= MYjTRW5ITVJ?
23132-87 NV;id3NNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PoeWlEPTB;NEGuNlc{OiEQvF2= M2DnSHNCVkeHUh?=
HCC1569 MlHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnO2TWM2OD12MT6yPFg2KM7:TR?= MkHXV2FPT0WU
CP66-MEL NYX5S25qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjWTWM2OD12Mj6xPFg3KM7:TR?= NYTUSHI2W0GQR1XS
K-562 NYLlPWt{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjRPI1KSzVyPUSyMlI5PTRizszN MUnTRW5ITVJ?
OCI-AML2 NXHJbmM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTR{Lki5O|Qh|ryP MoHUV2FPT0WU
SW756 M2fuRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jtOmlEPTB;NEOuNFM5QCEQvF2= NF3rUmZUSU6JRWK=
M14 NGXaV|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPQcohKSzVyPUSzMlMyQDlizszN M37zU3NCVkeHUh?=
NCI-H1623 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojJTWM2OD12Mz60OlQh|ryP MnrVV2FPT0WU
KNS-81-FD MmDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnncJNKSzVyPUSzMlc3OiEQvF2= NInh[ZRUSU6JRWK=
TGBC1TKB MmGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfZdoZEUUN3ME20N{46ODl7IN88US=> MV;TRW5ITVJ?
RERF-LC-MS NV:4UoNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPjZpVlUUN3ME20N{46OjhzIN88US=> NFeyfoZUSU6JRWK=
PC-3 MmLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTR2LkSzOFch|ryP NX24VHptW0GQR1XS
HuP-T4 NHrQXI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDUb5dKSzVyPUS0MlQ1PzRizszN M37PfHNCVkeHUh?=
NCI-H510A NGnzUFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvvTWM2OD12ND63NFgh|ryP MmfyV2FPT0WU
LB2518-MEL MmTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTR2Lke5N|ch|ryP Mn[zV2FPT0WU
TE-5 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnqxTWM2OD12NT65OVgyKM7:TR?= M1qweXNCVkeHUh?=
EW-24 M{PBZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfPR4NKSzVyPUS2MlE4OjNizszN MVjTRW5ITVJ?
LB647-SCLC Ml6zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\QWWlEPTB;NE[uNlE2PSEQvF2= MVLTRW5ITVJ?
NCI-H524 MoHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXv0dohTUUN3ME20Ok44OTh3IN88US=> M1HFZnNCVkeHUh?=
EW-11 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknxTWM2OD12Nj65N|c{KM7:TR?= NW\aOWlGW0GQR1XS
KALS-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofSTWM2OD12Nz6yNFY3KM7:TR?= NYnNUpNGW0GQR1XS
BT-474 M3XRNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTR5LkSyNVYh|ryP MmDsV2FPT0WU
SK-N-AS NWTMSWp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTR5Lki4PEDPxE1? MYjTRW5ITVJ?
HCC2157 NELNWWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHiTWM2OD12OD6wO|Yh|ryP NIX0OnVUSU6JRWK=
HCC1954 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTR6LkG3NFQh|ryP MnXzV2FPT0WU
FADU NY\QbopYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlT1TWM2OD12OD6zNFMyKM7:TR?= NE\tU5FUSU6JRWK=
S-117 NV7h[WxHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTR6LkO4NVUh|ryP M4e4e3NCVkeHUh?=
LS-1034 NELsOJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH72NpRKSzVyPUS4MlcxPjdizszN M3HGNXNCVkeHUh?=
CAMA-1 NGXSd5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XjVGlEPTB;NEmuOVU1OyEQvF2= Mn\WV2FPT0WU
LU-134-A MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHMZpZ[UUN3ME20PU45ODh3IN88US=> Moj6V2FPT0WU
NCI-H1838 NETtXXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\aNGlEPTB;NEmuPFA5PyEQvF2= M2exWnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

体内研究 Ponatinib抑制取自FLT3-ITD阳性AML病人的原代白血病细胞,而不抑制表达阴性FLT3的AML病人的白血病细胞。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
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激酶实验:

通过同质时间分辨荧光共振能量转移法(TR-FRET),使用纯化的人类野生型ABL激酶,T315I突变型ABL激酶,及生物素化的磷酸激酶底物肽: 生物素-EKKMAAEAIYAAPFAK-NH2,测定野生型ABL和T315I突变型ABL活性的抑制激酶反应在全LANCE激酶buffer (LKB)中进行,LKB包括20 mM NaHEPES(pH 为7.4), 0.1 mg ⁄ mL BSA, 1 mM ATP, 10 mM MgCl2, 及0.41 mM DTT,在提前用1% BSA(溶于PBS)包被的96孔板上4oC下过夜。用于激酶反应,Ponatinib稀释物和野生型ABL, T315I突变型ABL (40 pM), 及底物肽(50 nM), 在室温下温育1小时(T315I突变型ABL)或2小时(野生型ABL)。加入15 nM 抑制剂, 6 nM 铕标记的磷酸酪氨酸抗体(磷酸化位点在第66为酪氨酸上),及60 nM 别藻蓝素标记的链酶亲和素,终止反应。实验板在室温下黑暗温育20分钟,使用Wallac Victor2V读数器读取615和665nm处的荧光值。在孔中数据平均值中插入抑制剂的3倍连续稀释液,再读取665nm处荧光值,计算IC50值。
细胞实验:[1]
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  • Cell lines: Ba ⁄ F3细胞
  • Concentrations: 0-625 nM, 和0-10 µM
  • Incubation Time: 72小时
  • Method: Ba/F3细胞系按每孔4×103个细胞分布在96孔板上(4×103),和梯度浓度Ponatinib温育72小时。Ponatinib浓度范围为: 0-625 nM 作用于表达BCR-ABL细胞,0-10 µM 用于测定BCR-ABL阴性细胞。使用MTS实验测定细胞增殖,取三次平行实验平均值测定IC50值。
    (Only for Reference)
动物实验:[3]
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  • Animal Models: 皮下植入MV4-11细胞移植瘤(1×107,50%基质胶中) 的雌性CB.17 SCID鼠
  • Formulation: 25 mmol/L柠檬酸盐缓冲液(pH 为2.75)
  • Dosages: 每天处理一次,持续4周
  • Administration: 口服饲喂处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
1% CMC Na
30mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 532.56
化学式

C29H27F3N6O

CAS号 943319-70-8
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03147612 Recruiting Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia With BCR-ABL1|Philadelphia Chromosome Positive|Recurrent Acute Lymphoblastic Leukemia|Refractory Acute Lymphoblastic Leukemia M.D. Anderson Cancer Center|National Cancer Institute (NCI) February 8 2018 Phase 2
NCT01874665 Completed GIST Ariad Pharmaceuticals|Takeda June 5 2013 Phase 2
NCT02627677 Active not recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals|Takeda December 31 2015 Phase 3
NCT01667133 Completed Chronic Myeloid Leukemia (CML)|Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL) Ariad Pharmaceuticals|Takeda August 31 2012 Phase 1|Phase 2
NCT02467270 Recruiting Myeloid Leukemia Chronic Chronic Phase Ariad Pharmaceuticals June 30 2015 Phase 2
NCT01207440 Active not recruiting Chronic Myeloid Leukemia|Ph+ Acute Lymphoblastic Leukemia Ariad Pharmaceuticals|Takeda September 30 2010 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID